-- dump date 20140620_070947 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471855000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 471855000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 471855000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000004 Walker A motif; other site 471855000005 ATP binding site [chemical binding]; other site 471855000006 Walker B motif; other site 471855000007 arginine finger; other site 471855000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471855000009 DnaA box-binding interface [nucleotide binding]; other site 471855000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 471855000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471855000012 putative DNA binding surface [nucleotide binding]; other site 471855000013 dimer interface [polypeptide binding]; other site 471855000014 beta-clamp/clamp loader binding surface; other site 471855000015 beta-clamp/translesion DNA polymerase binding surface; other site 471855000016 recombination protein F; Reviewed; Region: recF; PRK00064 471855000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000018 Walker A/P-loop; other site 471855000019 ATP binding site [chemical binding]; other site 471855000020 Q-loop/lid; other site 471855000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000022 ABC transporter signature motif; other site 471855000023 Walker B; other site 471855000024 D-loop; other site 471855000025 H-loop/switch region; other site 471855000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 471855000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471855000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855000029 ATP binding site [chemical binding]; other site 471855000030 Mg2+ binding site [ion binding]; other site 471855000031 G-X-G motif; other site 471855000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471855000033 anchoring element; other site 471855000034 dimer interface [polypeptide binding]; other site 471855000035 ATP binding site [chemical binding]; other site 471855000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471855000037 active site 471855000038 putative metal-binding site [ion binding]; other site 471855000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471855000040 DNA gyrase subunit A; Validated; Region: PRK05560 471855000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471855000042 CAP-like domain; other site 471855000043 active site 471855000044 primary dimer interface [polypeptide binding]; other site 471855000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471855000051 MULE transposase domain; Region: MULE; pfam10551 471855000052 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471855000053 metal ion-dependent adhesion site (MIDAS); other site 471855000054 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855000055 domain interaction interfaces [polypeptide binding]; other site 471855000056 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855000057 domain interaction interfaces [polypeptide binding]; other site 471855000058 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 471855000059 flagellin; Validated; Region: PRK08026 471855000060 T surface-antigen of pili; Region: FctA; pfam12892 471855000061 T surface-antigen of pili; Region: FctA; cl16948 471855000062 T surface-antigen of pili; Region: FctA; pfam12892 471855000063 T surface-antigen of pili; Region: FctA; cl16948 471855000064 T surface-antigen of pili; Region: FctA; pfam12892 471855000065 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 471855000066 T surface-antigen of pili; Region: FctA; cl16948 471855000067 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 471855000068 Protein of unknown function (DUF554); Region: DUF554; pfam04474 471855000069 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 471855000070 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471855000071 nucleoside/Zn binding site; other site 471855000072 dimer interface [polypeptide binding]; other site 471855000073 catalytic motif [active] 471855000074 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 471855000075 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471855000076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855000077 motif II; other site 471855000078 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471855000079 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471855000080 active site 471855000081 trimer interface [polypeptide binding]; other site 471855000082 allosteric site; other site 471855000083 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471855000084 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471855000085 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471855000086 Yqey-like protein; Region: YqeY; cl17540 471855000087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855000088 FeS/SAM binding site; other site 471855000089 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471855000090 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471855000091 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471855000092 Bacterial PH domain; Region: DUF304; pfam03703 471855000093 Bacterial PH domain; Region: DUF304; pfam03703 471855000094 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 471855000095 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 471855000096 PspC domain; Region: PspC; pfam04024 471855000097 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471855000098 TrkA-N domain; Region: TrkA_N; pfam02254 471855000099 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471855000100 TrkA-N domain; Region: TrkA_N; pfam02254 471855000101 adenylosuccinate lyase; Provisional; Region: PRK07492 471855000102 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 471855000103 tetramer interface [polypeptide binding]; other site 471855000104 active site 471855000105 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 471855000106 Surface antigen [General function prediction only]; Region: COG3942 471855000107 CHAP domain; Region: CHAP; pfam05257 471855000108 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855000109 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000110 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000111 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855000112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855000113 active site 471855000114 phosphorylation site [posttranslational modification] 471855000115 intermolecular recognition site; other site 471855000116 dimerization interface [polypeptide binding]; other site 471855000117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855000118 DNA binding site [nucleotide binding] 471855000119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855000120 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471855000121 dimerization interface [polypeptide binding]; other site 471855000122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855000123 dimer interface [polypeptide binding]; other site 471855000124 phosphorylation site [posttranslational modification] 471855000125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855000126 ATP binding site [chemical binding]; other site 471855000127 Mg2+ binding site [ion binding]; other site 471855000128 G-X-G motif; other site 471855000129 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471855000130 active site 471855000131 ATP binding site [chemical binding]; other site 471855000132 substrate binding site [chemical binding]; other site 471855000133 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471855000134 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471855000135 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 471855000136 Histidine kinase; Region: His_kinase; pfam06580 471855000137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855000138 ATP binding site [chemical binding]; other site 471855000139 Mg2+ binding site [ion binding]; other site 471855000140 G-X-G motif; other site 471855000141 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471855000142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855000143 active site 471855000144 phosphorylation site [posttranslational modification] 471855000145 intermolecular recognition site; other site 471855000146 dimerization interface [polypeptide binding]; other site 471855000147 LytTr DNA-binding domain; Region: LytTR; smart00850 471855000148 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855000149 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855000150 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471855000151 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471855000152 Catalytic site [active] 471855000153 T surface-antigen of pili; Region: FctA; cl16948 471855000154 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 471855000155 active site 471855000156 catalytic site [active] 471855000157 Cytochrome c552; Region: Cytochrom_C552; pfam02335 471855000158 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 471855000159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471855000160 dimerization interface [polypeptide binding]; other site 471855000161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855000162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855000163 DNA binding site [nucleotide binding] 471855000164 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471855000165 active site 471855000166 dimer interface [polypeptide binding]; other site 471855000167 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 471855000168 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 471855000169 dimerization interface [polypeptide binding]; other site 471855000170 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 471855000171 ATP binding site [chemical binding]; other site 471855000172 tryptophan synthase subunit beta; Reviewed; Region: PRK12391 471855000173 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 471855000174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855000175 catalytic residue [active] 471855000176 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 471855000177 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 471855000178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855000179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855000180 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 471855000181 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 471855000182 HupF/HypC family; Region: HupF_HypC; pfam01455 471855000183 Acylphosphatase; Region: Acylphosphatase; pfam00708 471855000184 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 471855000185 HypF finger; Region: zf-HYPF; pfam07503 471855000186 HypF finger; Region: zf-HYPF; pfam07503 471855000187 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 471855000188 nickel responsive regulator; Provisional; Region: PRK04460 471855000189 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 471855000190 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 471855000191 Ferredoxin [Energy production and conversion]; Region: COG1146 471855000192 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855000193 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 471855000194 putative active site [active] 471855000195 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 471855000196 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471855000197 homodimer interface [polypeptide binding]; other site 471855000198 metal binding site [ion binding]; metal-binding site 471855000199 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 471855000200 homodimer interface [polypeptide binding]; other site 471855000201 active site 471855000202 putative chemical substrate binding site [chemical binding]; other site 471855000203 metal binding site [ion binding]; metal-binding site 471855000204 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855000205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855000206 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855000207 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 471855000208 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 471855000209 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855000210 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855000211 FeS/SAM binding site; other site 471855000212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855000213 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 471855000214 NAD(P) binding site [chemical binding]; other site 471855000215 active site 471855000216 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 471855000217 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000218 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000219 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000220 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000221 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000222 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000223 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000224 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000225 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000226 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000227 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000228 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000229 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000230 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000231 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000232 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855000233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855000234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000235 Walker A/P-loop; other site 471855000236 ATP binding site [chemical binding]; other site 471855000237 Q-loop/lid; other site 471855000238 ABC transporter signature motif; other site 471855000239 Walker B; other site 471855000240 D-loop; other site 471855000241 H-loop/switch region; other site 471855000242 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855000243 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855000244 Walker A/P-loop; other site 471855000245 ATP binding site [chemical binding]; other site 471855000246 Q-loop/lid; other site 471855000247 ABC transporter signature motif; other site 471855000248 Walker B; other site 471855000249 D-loop; other site 471855000250 H-loop/switch region; other site 471855000251 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855000252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000253 Walker A/P-loop; other site 471855000254 ATP binding site [chemical binding]; other site 471855000255 Q-loop/lid; other site 471855000256 ABC transporter signature motif; other site 471855000257 Walker B; other site 471855000258 D-loop; other site 471855000259 H-loop/switch region; other site 471855000260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855000261 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855000262 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000263 Walker A/P-loop; other site 471855000264 ATP binding site [chemical binding]; other site 471855000265 Q-loop/lid; other site 471855000266 ABC transporter signature motif; other site 471855000267 Walker B; other site 471855000268 D-loop; other site 471855000269 H-loop/switch region; other site 471855000270 Cobalt transport protein; Region: CbiQ; cl00463 471855000271 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 471855000272 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855000273 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855000274 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 471855000275 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855000276 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855000277 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 471855000278 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855000279 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471855000280 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471855000281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855000282 non-specific DNA binding site [nucleotide binding]; other site 471855000283 salt bridge; other site 471855000284 sequence-specific DNA binding site [nucleotide binding]; other site 471855000285 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855000286 catalytic core [active] 471855000287 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 471855000288 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 471855000289 active site 471855000290 metal binding site [ion binding]; metal-binding site 471855000291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855000292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855000293 DNA binding residues [nucleotide binding] 471855000294 dimerization interface [polypeptide binding]; other site 471855000295 Predicted membrane protein [Function unknown]; Region: COG1288 471855000296 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 471855000297 ornithine carbamoyltransferase; Validated; Region: PRK02102 471855000298 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471855000299 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471855000300 carbamate kinase; Reviewed; Region: PRK12686 471855000301 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471855000302 putative substrate binding site [chemical binding]; other site 471855000303 nucleotide binding site [chemical binding]; other site 471855000304 nucleotide binding site [chemical binding]; other site 471855000305 homodimer interface [polypeptide binding]; other site 471855000306 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471855000307 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471855000308 catalytic triad [active] 471855000309 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855000310 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000311 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000312 CAAX protease self-immunity; Region: Abi; pfam02517 471855000313 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855000314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855000315 non-specific DNA binding site [nucleotide binding]; other site 471855000316 salt bridge; other site 471855000317 sequence-specific DNA binding site [nucleotide binding]; other site 471855000318 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471855000319 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471855000320 DNA binding residues [nucleotide binding] 471855000321 putative dimer interface [polypeptide binding]; other site 471855000322 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 471855000323 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471855000324 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855000325 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855000326 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855000327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855000328 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 471855000329 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 471855000330 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 471855000331 putative NAD(P) binding site [chemical binding]; other site 471855000332 catalytic Zn binding site [ion binding]; other site 471855000333 structural Zn binding site [ion binding]; other site 471855000334 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855000335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855000336 non-specific DNA binding site [nucleotide binding]; other site 471855000337 salt bridge; other site 471855000338 sequence-specific DNA binding site [nucleotide binding]; other site 471855000339 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471855000340 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 471855000341 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471855000342 putative substrate binding site [chemical binding]; other site 471855000343 putative ATP binding site [chemical binding]; other site 471855000344 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 471855000345 heat shock protein 90; Provisional; Region: PRK05218 471855000346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855000347 ATP binding site [chemical binding]; other site 471855000348 Mg2+ binding site [ion binding]; other site 471855000349 G-X-G motif; other site 471855000350 acyl carrier protein; Provisional; Region: acpP; PRK00982 471855000351 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 471855000352 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471855000353 FMN binding site [chemical binding]; other site 471855000354 substrate binding site [chemical binding]; other site 471855000355 putative catalytic residue [active] 471855000356 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471855000357 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471855000358 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471855000359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855000360 NAD(P) binding site [chemical binding]; other site 471855000361 active site 471855000362 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471855000363 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471855000364 dimer interface [polypeptide binding]; other site 471855000365 active site 471855000366 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 471855000367 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471855000368 carboxyltransferase (CT) interaction site; other site 471855000369 biotinylation site [posttranslational modification]; other site 471855000370 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 471855000371 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471855000372 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471855000373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471855000374 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471855000375 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 471855000376 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471855000377 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471855000378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855000379 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471855000380 acyl-activating enzyme (AAE) consensus motif; other site 471855000381 AMP binding site [chemical binding]; other site 471855000382 active site 471855000383 CoA binding site [chemical binding]; other site 471855000384 PAS domain; Region: PAS_9; pfam13426 471855000385 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471855000386 putative active site [active] 471855000387 heme pocket [chemical binding]; other site 471855000388 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471855000389 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 471855000390 nucleotide binding site [chemical binding]; other site 471855000391 NEF interaction site [polypeptide binding]; other site 471855000392 SBD interface [polypeptide binding]; other site 471855000393 GrpE; Region: GrpE; pfam01025 471855000394 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471855000395 dimer interface [polypeptide binding]; other site 471855000396 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471855000397 chaperone protein DnaJ; Provisional; Region: PRK14280 471855000398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471855000399 HSP70 interaction site [polypeptide binding]; other site 471855000400 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471855000401 substrate binding site [polypeptide binding]; other site 471855000402 dimer interface [polypeptide binding]; other site 471855000403 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471855000404 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471855000405 DNA binding residues [nucleotide binding] 471855000406 putative dimer interface [polypeptide binding]; other site 471855000407 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471855000408 Clp amino terminal domain; Region: Clp_N; pfam02861 471855000409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000410 Walker A motif; other site 471855000411 ATP binding site [chemical binding]; other site 471855000412 Walker B motif; other site 471855000413 arginine finger; other site 471855000414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000415 Walker A motif; other site 471855000416 ATP binding site [chemical binding]; other site 471855000417 Walker B motif; other site 471855000418 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471855000419 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471855000420 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471855000421 DNA-binding interface [nucleotide binding]; DNA binding site 471855000422 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855000423 Double zinc ribbon; Region: DZR; pfam12773 471855000424 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 471855000425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855000426 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471855000427 Ligand Binding Site [chemical binding]; other site 471855000428 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 471855000429 putative homodimer interface [polypeptide binding]; other site 471855000430 putative homotetramer interface [polypeptide binding]; other site 471855000431 putative allosteric switch controlling residues; other site 471855000432 putative metal binding site [ion binding]; other site 471855000433 putative homodimer-homodimer interface [polypeptide binding]; other site 471855000434 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471855000435 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471855000436 metal-binding site [ion binding] 471855000437 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471855000438 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471855000439 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471855000440 metal-binding site [ion binding] 471855000441 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 471855000442 metal-binding site [ion binding] 471855000443 TSCPD domain; Region: TSCPD; cl14834 471855000444 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471855000445 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471855000446 putative active site [active] 471855000447 putative metal binding site [ion binding]; other site 471855000448 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 471855000449 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 471855000450 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471855000451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855000452 active site 471855000453 motif I; other site 471855000454 motif II; other site 471855000455 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 471855000456 Na binding site [ion binding]; other site 471855000457 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 471855000458 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471855000459 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 471855000460 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471855000461 Predicted GTPases [General function prediction only]; Region: COG1162 471855000462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471855000463 RNA binding site [nucleotide binding]; other site 471855000464 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471855000465 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471855000466 GTP/Mg2+ binding site [chemical binding]; other site 471855000467 G4 box; other site 471855000468 G5 box; other site 471855000469 G1 box; other site 471855000470 Switch I region; other site 471855000471 G2 box; other site 471855000472 G3 box; other site 471855000473 Switch II region; other site 471855000474 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471855000475 active site 471855000476 catalytic triad [active] 471855000477 oxyanion hole [active] 471855000478 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471855000479 metal ion-dependent adhesion site (MIDAS); other site 471855000480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 471855000481 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 471855000482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855000483 putative substrate translocation pore; other site 471855000484 TM2 domain; Region: TM2; cl00984 471855000485 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 471855000486 elongation factor G; Reviewed; Region: PRK12740 471855000487 G1 box; other site 471855000488 putative GEF interaction site [polypeptide binding]; other site 471855000489 GTP/Mg2+ binding site [chemical binding]; other site 471855000490 Switch I region; other site 471855000491 G2 box; other site 471855000492 G3 box; other site 471855000493 Switch II region; other site 471855000494 G4 box; other site 471855000495 G5 box; other site 471855000496 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471855000497 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471855000498 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471855000499 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471855000500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855000501 S-adenosylmethionine binding site [chemical binding]; other site 471855000502 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 471855000503 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471855000504 active site 471855000505 Trp repressor protein; Region: Trp_repressor; cl17266 471855000506 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 471855000507 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 471855000508 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471855000509 GTP binding site; other site 471855000510 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 471855000511 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855000512 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471855000513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471855000514 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471855000515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855000516 dimer interface [polypeptide binding]; other site 471855000517 conserved gate region; other site 471855000518 putative PBP binding loops; other site 471855000519 ABC-ATPase subunit interface; other site 471855000520 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 471855000521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855000522 Walker A/P-loop; other site 471855000523 ATP binding site [chemical binding]; other site 471855000524 Q-loop/lid; other site 471855000525 ABC transporter signature motif; other site 471855000526 Walker B; other site 471855000527 D-loop; other site 471855000528 H-loop/switch region; other site 471855000529 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 471855000530 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855000531 FeS/SAM binding site; other site 471855000532 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471855000533 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 471855000534 trimer interface [polypeptide binding]; other site 471855000535 dimer interface [polypeptide binding]; other site 471855000536 putative active site [active] 471855000537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471855000538 Helix-turn-helix domain; Region: HTH_28; pfam13518 471855000539 putative transposase OrfB; Reviewed; Region: PHA02517 471855000540 HTH-like domain; Region: HTH_21; pfam13276 471855000541 Integrase core domain; Region: rve; pfam00665 471855000542 Integrase core domain; Region: rve_2; pfam13333 471855000543 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471855000544 MPT binding site; other site 471855000545 trimer interface [polypeptide binding]; other site 471855000546 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471855000547 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471855000548 dimer interface [polypeptide binding]; other site 471855000549 putative functional site; other site 471855000550 putative MPT binding site; other site 471855000551 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471855000552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855000553 S-adenosylmethionine binding site [chemical binding]; other site 471855000554 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 471855000555 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 471855000556 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471855000557 active site 471855000558 HIGH motif; other site 471855000559 KMSK motif region; other site 471855000560 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471855000561 tRNA binding surface [nucleotide binding]; other site 471855000562 anticodon binding site; other site 471855000563 polyphosphate kinase; Provisional; Region: PRK05443 471855000564 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471855000565 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471855000566 Catalytic C-terminal domain, first repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C1_unchar; cd09166 471855000567 putative domain interface [polypeptide binding]; other site 471855000568 putative active site [active] 471855000569 catalytic site [active] 471855000570 Catalytic C-terminal domain, second repeat, of uncharacterized prokaryotic polyphosphate kinases; Region: PLDc_PPK1_C2_unchar; cd09169 471855000571 putative domain interface [polypeptide binding]; other site 471855000572 putative active site [active] 471855000573 catalytic site [active] 471855000574 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 471855000575 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 471855000576 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 471855000577 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471855000578 active site 471855000579 catalytic site [active] 471855000580 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 471855000581 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471855000582 active site 471855000583 tetramer interface [polypeptide binding]; other site 471855000584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855000585 active site 471855000586 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471855000587 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471855000588 dimerization interface [polypeptide binding]; other site 471855000589 putative ATP binding site [chemical binding]; other site 471855000590 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471855000591 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471855000592 active site 471855000593 substrate binding site [chemical binding]; other site 471855000594 cosubstrate binding site; other site 471855000595 catalytic site [active] 471855000596 XdhC Rossmann domain; Region: XdhC_C; pfam13478 471855000597 HIRAN domain; Region: HIRAN; pfam08797 471855000598 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471855000599 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471855000600 Walker A/P-loop; other site 471855000601 ATP binding site [chemical binding]; other site 471855000602 Q-loop/lid; other site 471855000603 ABC transporter signature motif; other site 471855000604 Walker B; other site 471855000605 D-loop; other site 471855000606 H-loop/switch region; other site 471855000607 FtsX-like permease family; Region: FtsX; pfam02687 471855000608 FtsX-like permease family; Region: FtsX; pfam02687 471855000609 MOSC domain; Region: MOSC; pfam03473 471855000610 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 471855000611 aspartate aminotransferase; Provisional; Region: PRK06836 471855000612 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855000614 homodimer interface [polypeptide binding]; other site 471855000615 catalytic residue [active] 471855000616 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 471855000617 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 471855000618 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471855000619 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 471855000620 Ferritin-like domain; Region: Ferritin; pfam00210 471855000621 ferroxidase diiron center [ion binding]; other site 471855000622 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 471855000623 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471855000624 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471855000625 Walker A/P-loop; other site 471855000626 ATP binding site [chemical binding]; other site 471855000627 Q-loop/lid; other site 471855000628 ABC transporter signature motif; other site 471855000629 Walker B; other site 471855000630 D-loop; other site 471855000631 H-loop/switch region; other site 471855000632 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 471855000633 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 471855000634 FtsX-like permease family; Region: FtsX; pfam02687 471855000635 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471855000636 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471855000637 FtsX-like permease family; Region: FtsX; pfam02687 471855000638 G5 domain; Region: G5; pfam07501 471855000639 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471855000640 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 471855000641 NodB motif; other site 471855000642 active site 471855000643 catalytic site [active] 471855000644 metal binding site [ion binding]; metal-binding site 471855000645 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471855000646 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471855000647 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471855000648 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 471855000649 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471855000650 PYR/PP interface [polypeptide binding]; other site 471855000651 dimer interface [polypeptide binding]; other site 471855000652 TPP binding site [chemical binding]; other site 471855000653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471855000654 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471855000655 TPP-binding site [chemical binding]; other site 471855000656 dimer interface [polypeptide binding]; other site 471855000657 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471855000658 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471855000659 putative valine binding site [chemical binding]; other site 471855000660 dimer interface [polypeptide binding]; other site 471855000661 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471855000662 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855000663 PBP superfamily domain; Region: PBP_like; pfam12727 471855000664 molybdenum-pterin binding domain; Region: Mop; TIGR00638 471855000665 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 471855000666 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855000667 active site 471855000668 FtsH Extracellular; Region: FtsH_ext; pfam06480 471855000669 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471855000670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000671 Walker A motif; other site 471855000672 ATP binding site [chemical binding]; other site 471855000673 Walker B motif; other site 471855000674 arginine finger; other site 471855000675 Peptidase family M41; Region: Peptidase_M41; pfam01434 471855000676 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 471855000677 dihydropteroate synthase; Region: DHPS; TIGR01496 471855000678 substrate binding pocket [chemical binding]; other site 471855000679 dimer interface [polypeptide binding]; other site 471855000680 inhibitor binding site; inhibition site 471855000681 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471855000682 catalytic center binding site [active] 471855000683 ATP binding site [chemical binding]; other site 471855000684 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 471855000685 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 471855000686 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471855000687 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 471855000688 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471855000689 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 471855000690 Predicted transcriptional regulators [Transcription]; Region: COG1725 471855000691 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855000692 DNA-binding site [nucleotide binding]; DNA binding site 471855000693 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471855000694 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471855000695 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855000696 molybdopterin cofactor binding site; other site 471855000697 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855000698 molybdopterin cofactor binding site; other site 471855000699 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855000700 4Fe-4S binding domain; Region: Fer4_6; pfam12837 471855000701 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 471855000702 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471855000703 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471855000704 Walker A/P-loop; other site 471855000705 ATP binding site [chemical binding]; other site 471855000706 Q-loop/lid; other site 471855000707 ABC transporter signature motif; other site 471855000708 Walker B; other site 471855000709 D-loop; other site 471855000710 H-loop/switch region; other site 471855000711 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471855000712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471855000713 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855000714 Double zinc ribbon; Region: DZR; pfam12773 471855000715 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855000716 Double zinc ribbon; Region: DZR; pfam12773 471855000717 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 471855000718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855000719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855000720 dimer interface [polypeptide binding]; other site 471855000721 phosphorylation site [posttranslational modification] 471855000722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855000723 ATP binding site [chemical binding]; other site 471855000724 Mg2+ binding site [ion binding]; other site 471855000725 G-X-G motif; other site 471855000726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855000727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855000728 active site 471855000729 phosphorylation site [posttranslational modification] 471855000730 intermolecular recognition site; other site 471855000731 dimerization interface [polypeptide binding]; other site 471855000732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855000733 DNA binding site [nucleotide binding] 471855000734 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 471855000735 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 471855000736 active site 471855000737 metal binding site [ion binding]; metal-binding site 471855000738 BioY family; Region: BioY; pfam02632 471855000739 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471855000740 Glycoprotease family; Region: Peptidase_M22; pfam00814 471855000741 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471855000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855000743 Coenzyme A binding pocket [chemical binding]; other site 471855000744 UGMP family protein; Validated; Region: PRK09604 471855000745 Predicted transcriptional regulators [Transcription]; Region: COG1733 471855000746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855000747 putative DNA binding site [nucleotide binding]; other site 471855000748 putative Zn2+ binding site [ion binding]; other site 471855000749 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855000750 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855000751 FeS/SAM binding site; other site 471855000752 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 471855000753 DNA polymerase IV; Reviewed; Region: PRK03103 471855000754 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 471855000755 active site 471855000756 DNA binding site [nucleotide binding] 471855000757 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471855000758 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471855000759 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471855000760 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471855000761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000762 Walker A motif; other site 471855000763 ATP binding site [chemical binding]; other site 471855000764 Walker B motif; other site 471855000765 arginine finger; other site 471855000766 hypothetical protein; Validated; Region: PRK00153 471855000767 recombination protein RecR; Reviewed; Region: recR; PRK00076 471855000768 RecR protein; Region: RecR; pfam02132 471855000769 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471855000770 putative active site [active] 471855000771 putative metal-binding site [ion binding]; other site 471855000772 tetramer interface [polypeptide binding]; other site 471855000773 Amidinotransferase; Region: Amidinotransf; cl12043 471855000774 ornithine carbamoyltransferase; Validated; Region: PRK02102 471855000775 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471855000776 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471855000777 carbamate kinase; Reviewed; Region: PRK12686 471855000778 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471855000779 putative substrate binding site [chemical binding]; other site 471855000780 nucleotide binding site [chemical binding]; other site 471855000781 nucleotide binding site [chemical binding]; other site 471855000782 homodimer interface [polypeptide binding]; other site 471855000783 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855000784 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 471855000785 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855000786 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855000787 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855000788 molybdopterin cofactor binding site; other site 471855000789 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855000790 molybdopterin cofactor binding site; other site 471855000791 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471855000792 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855000793 DNA-binding site [nucleotide binding]; DNA binding site 471855000794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855000795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855000796 homodimer interface [polypeptide binding]; other site 471855000797 catalytic residue [active] 471855000798 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 471855000799 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 471855000800 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000801 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855000802 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 471855000803 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855000804 MarR family; Region: MarR_2; cl17246 471855000805 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855000806 MarR family; Region: MarR_2; pfam12802 471855000807 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855000808 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855000809 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855000810 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000811 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000812 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855000813 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471855000814 MULE transposase domain; Region: MULE; pfam10551 471855000815 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 471855000816 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 471855000817 active site 471855000818 substrate-binding site [chemical binding]; other site 471855000819 metal-binding site [ion binding] 471855000820 ATP binding site [chemical binding]; other site 471855000821 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 471855000822 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471855000823 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471855000824 AAA domain; Region: AAA_22; pfam13401 471855000825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000826 Walker A motif; other site 471855000827 ATP binding site [chemical binding]; other site 471855000828 Walker B motif; other site 471855000829 arginine finger; other site 471855000830 4Fe-4S binding domain; Region: Fer4; cl02805 471855000831 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 471855000832 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471855000833 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471855000834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855000835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855000836 DNA binding residues [nucleotide binding] 471855000837 dimerization interface [polypeptide binding]; other site 471855000838 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471855000839 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471855000840 active site 471855000841 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471855000842 Ligand binding site [chemical binding]; other site 471855000843 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471855000844 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471855000845 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471855000846 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471855000847 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 471855000848 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 471855000849 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471855000850 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 471855000851 Archaeal ATPase; Region: Arch_ATPase; pfam01637 471855000852 AAA ATPase domain; Region: AAA_16; pfam13191 471855000853 MarR family; Region: MarR_2; pfam12802 471855000854 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855000855 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855000856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855000857 non-specific DNA binding site [nucleotide binding]; other site 471855000858 salt bridge; other site 471855000859 sequence-specific DNA binding site [nucleotide binding]; other site 471855000860 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 471855000861 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471855000862 MULE transposase domain; Region: MULE; pfam10551 471855000863 recombination endonuclease VII; Provisional; Region: 49; PHA02565 471855000864 Protein of unknown function DUF262; Region: DUF262; pfam03235 471855000865 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471855000866 Uncharacterized conserved protein [Function unknown]; Region: COG3472 471855000867 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 471855000868 active site 471855000869 NTP binding site [chemical binding]; other site 471855000870 metal binding triad [ion binding]; metal-binding site 471855000871 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 471855000872 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 471855000873 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 471855000874 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855000875 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 471855000876 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 471855000877 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855000878 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 471855000879 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 471855000880 TIGR02687 family protein; Region: TIGR02687 471855000881 PglZ domain; Region: PglZ; pfam08665 471855000882 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 471855000883 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 471855000884 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471855000885 Protein of unknown function DUF262; Region: DUF262; pfam03235 471855000886 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471855000887 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471855000888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855000889 S-adenosylmethionine binding site [chemical binding]; other site 471855000890 HNH endonuclease; Region: HNH_4; pfam13395 471855000891 Predicted transcriptional regulators [Transcription]; Region: COG1725 471855000892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855000893 DNA-binding site [nucleotide binding]; DNA binding site 471855000894 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471855000895 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471855000896 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855000897 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471855000898 Moco binding site; other site 471855000899 metal coordination site [ion binding]; other site 471855000900 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855000901 Moco binding site; other site 471855000902 metal coordination site [ion binding]; other site 471855000903 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855000904 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855000905 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 471855000906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855000907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855000908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855000909 dimerization interface [polypeptide binding]; other site 471855000910 FAD binding domain; Region: FAD_binding_2; pfam00890 471855000911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855000912 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 471855000913 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855000914 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855000915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855000916 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855000917 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 471855000918 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 471855000919 active site 471855000920 FMN binding site [chemical binding]; other site 471855000921 substrate binding site [chemical binding]; other site 471855000922 putative catalytic residue [active] 471855000923 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471855000924 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471855000925 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471855000926 classical (c) SDRs; Region: SDR_c; cd05233 471855000927 NAD(P) binding site [chemical binding]; other site 471855000928 active site 471855000929 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 471855000930 Short C-terminal domain; Region: SHOCT; pfam09851 471855000931 Integrase core domain; Region: rve; pfam00665 471855000932 Integrase core domain; Region: rve_2; pfam13333 471855000933 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471855000934 Helix-turn-helix domain; Region: HTH_28; pfam13518 471855000935 putative transposase OrfB; Reviewed; Region: PHA02517 471855000936 HTH-like domain; Region: HTH_21; pfam13276 471855000937 Integrase core domain; Region: rve; pfam00665 471855000938 Integrase core domain; Region: rve_2; pfam13333 471855000939 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471855000940 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855000941 active site 471855000942 ATP binding site [chemical binding]; other site 471855000943 substrate binding site [chemical binding]; other site 471855000944 activation loop (A-loop); other site 471855000945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471855000946 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 471855000947 Protein phosphatase 2C; Region: PP2C; pfam00481 471855000948 active site 471855000949 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 471855000950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000951 ATP binding site [chemical binding]; other site 471855000952 Walker B motif; other site 471855000953 arginine finger; other site 471855000954 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471855000955 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471855000956 active site 471855000957 ATP binding site [chemical binding]; other site 471855000958 substrate binding site [chemical binding]; other site 471855000959 activation loop (A-loop); other site 471855000960 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471855000961 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855000962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000963 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471855000964 Walker A motif; other site 471855000965 ATP binding site [chemical binding]; other site 471855000966 Walker B motif; other site 471855000967 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471855000968 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 471855000969 DNA-binding interface [nucleotide binding]; DNA binding site 471855000970 Integrase core domain; Region: rve; pfam00665 471855000971 transposase/IS protein; Provisional; Region: PRK09183 471855000972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000973 Walker A motif; other site 471855000974 ATP binding site [chemical binding]; other site 471855000975 Walker B motif; other site 471855000976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 471855000977 Integrase core domain; Region: rve; pfam00665 471855000978 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855000979 Transposase, Mutator family; Region: Transposase_mut; pfam00872 471855000980 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 471855000981 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855000982 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 471855000983 active site 471855000984 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471855000985 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471855000986 phosphopeptide binding site; other site 471855000987 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 471855000988 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 471855000989 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471855000990 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471855000991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855000992 Walker A motif; other site 471855000993 Walker A motif; other site 471855000994 ATP binding site [chemical binding]; other site 471855000995 Walker B motif; other site 471855000996 TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926 471855000997 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855000998 Cupin domain; Region: Cupin_2; cl17218 471855000999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471855001000 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471855001001 substrate binding pocket [chemical binding]; other site 471855001002 membrane-bound complex binding site; other site 471855001003 hinge residues; other site 471855001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855001005 dimer interface [polypeptide binding]; other site 471855001006 conserved gate region; other site 471855001007 putative PBP binding loops; other site 471855001008 ABC-ATPase subunit interface; other site 471855001009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855001010 dimer interface [polypeptide binding]; other site 471855001011 conserved gate region; other site 471855001012 putative PBP binding loops; other site 471855001013 ABC-ATPase subunit interface; other site 471855001014 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471855001015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471855001016 Walker A/P-loop; other site 471855001017 ATP binding site [chemical binding]; other site 471855001018 Q-loop/lid; other site 471855001019 ABC transporter signature motif; other site 471855001020 Walker B; other site 471855001021 D-loop; other site 471855001022 H-loop/switch region; other site 471855001023 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471855001024 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855001026 Walker A motif; other site 471855001027 ATP binding site [chemical binding]; other site 471855001028 Walker B motif; other site 471855001029 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471855001030 Nuclease-related domain; Region: NERD; pfam08378 471855001031 RelB antitoxin; Region: RelB; cl01171 471855001032 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855001033 Predicted oxidoreductase [General function prediction only]; Region: COG3573 471855001034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855001035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855001036 DNA binding residues [nucleotide binding] 471855001037 dimerization interface [polypeptide binding]; other site 471855001038 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471855001039 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471855001040 Walker A/P-loop; other site 471855001041 ATP binding site [chemical binding]; other site 471855001042 Q-loop/lid; other site 471855001043 ABC transporter signature motif; other site 471855001044 Walker B; other site 471855001045 D-loop; other site 471855001046 H-loop/switch region; other site 471855001047 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471855001048 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471855001049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855001050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855001051 DNA binding residues [nucleotide binding] 471855001052 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 471855001053 active site 471855001054 metal binding site [ion binding]; metal-binding site 471855001055 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855001056 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 471855001057 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 471855001058 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 471855001059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001060 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471855001061 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 471855001062 dinuclear metal binding motif [ion binding]; other site 471855001063 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 471855001064 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 471855001065 L-aspartate oxidase; Provisional; Region: PRK06175 471855001066 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471855001067 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 471855001068 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471855001069 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471855001070 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471855001071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855001072 ATP binding site [chemical binding]; other site 471855001073 putative Mg++ binding site [ion binding]; other site 471855001074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855001075 nucleotide binding region [chemical binding]; other site 471855001076 ATP-binding site [chemical binding]; other site 471855001077 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 471855001078 PLD-like domain; Region: PLDc_2; pfam13091 471855001079 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 471855001080 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 471855001081 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471855001082 FMN binding site [chemical binding]; other site 471855001083 substrate binding site [chemical binding]; other site 471855001084 putative catalytic residue [active] 471855001085 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471855001086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471855001087 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471855001088 substrate binding pocket [chemical binding]; other site 471855001089 membrane-bound complex binding site; other site 471855001090 hinge residues; other site 471855001091 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471855001092 catalytic site [active] 471855001093 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471855001094 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471855001095 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855001096 active site 471855001097 substrate binding site [chemical binding]; other site 471855001098 activation loop (A-loop); other site 471855001099 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855001100 metal ion-dependent adhesion site (MIDAS); other site 471855001101 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471855001102 Protein phosphatase 2C; Region: PP2C_2; pfam13672 471855001103 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 471855001104 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855001105 metal ion-dependent adhesion site (MIDAS); other site 471855001106 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855001107 Sel1-like repeats; Region: SEL1; smart00671 471855001108 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855001109 Sel1-like repeats; Region: SEL1; smart00671 471855001110 Sel1-like repeats; Region: SEL1; smart00671 471855001111 Sel1-like repeats; Region: SEL1; smart00671 471855001112 Sel1-like repeats; Region: SEL1; smart00671 471855001113 Sel1-like repeats; Region: SEL1; smart00671 471855001114 Sel1-like repeats; Region: SEL1; smart00671 471855001115 Sel1-like repeats; Region: SEL1; smart00671 471855001116 Sel1-like repeats; Region: SEL1; smart00671 471855001117 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855001118 Sel1-like repeats; Region: SEL1; smart00671 471855001119 Sel1-like repeats; Region: SEL1; smart00671 471855001120 Sel1-like repeats; Region: SEL1; smart00671 471855001121 Sel1-like repeats; Region: SEL1; smart00671 471855001122 Sel1-like repeats; Region: SEL1; smart00671 471855001123 Sel1-like repeats; Region: SEL1; smart00671 471855001124 Sel1-like repeats; Region: SEL1; smart00671 471855001125 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855001126 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855001127 TrkA-N domain; Region: TrkA_N; pfam02254 471855001128 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855001129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001130 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 471855001131 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855001132 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855001133 acyl-activating enzyme (AAE) consensus motif; other site 471855001134 AMP binding site [chemical binding]; other site 471855001135 active site 471855001136 CoA binding site [chemical binding]; other site 471855001137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471855001138 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471855001139 substrate binding site [chemical binding]; other site 471855001140 oxyanion hole (OAH) forming residues; other site 471855001141 trimer interface [polypeptide binding]; other site 471855001142 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 471855001143 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471855001144 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471855001145 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855001146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855001147 FeS/SAM binding site; other site 471855001148 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 471855001149 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471855001150 FMN binding site [chemical binding]; other site 471855001151 substrate binding site [chemical binding]; other site 471855001152 putative catalytic residue [active] 471855001153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001154 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471855001155 DNA-binding interface [nucleotide binding]; DNA binding site 471855001156 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855001157 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855001158 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855001159 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471855001160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855001161 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855001162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471855001163 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471855001164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001165 non-specific DNA binding site [nucleotide binding]; other site 471855001166 salt bridge; other site 471855001167 sequence-specific DNA binding site [nucleotide binding]; other site 471855001168 SWIM zinc finger; Region: SWIM; pfam04434 471855001169 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855001170 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 471855001171 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855001172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001174 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 471855001175 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855001176 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001177 molybdopterin cofactor binding site; other site 471855001178 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855001179 molybdopterin cofactor binding site; other site 471855001180 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001181 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855001182 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471855001183 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471855001184 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 471855001185 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 471855001186 CPxP motif; other site 471855001187 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471855001188 active site residue [active] 471855001189 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471855001190 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 471855001191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471855001192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471855001193 catalytic residues [active] 471855001194 autotransport protein MisL; Provisional; Region: PRK15313 471855001195 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471855001196 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 471855001197 putative active site [active] 471855001198 catalytic triad [active] 471855001199 putative dimer interface [polypeptide binding]; other site 471855001200 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471855001201 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471855001202 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855001203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001204 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 471855001205 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 471855001206 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 471855001207 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855001208 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001209 Predicted acyl esterases [General function prediction only]; Region: COG2936 471855001210 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471855001211 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471855001212 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 471855001213 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 471855001214 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 471855001215 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855001216 Sporulation related domain; Region: SPOR; pfam05036 471855001217 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471855001218 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471855001219 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471855001220 Sulfatase; Region: Sulfatase; cl17466 471855001221 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 471855001222 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 471855001223 putative dimer interface [polypeptide binding]; other site 471855001224 putative anticodon binding site; other site 471855001225 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 471855001226 homodimer interface [polypeptide binding]; other site 471855001227 motif 1; other site 471855001228 motif 2; other site 471855001229 active site 471855001230 motif 3; other site 471855001231 trigger factor; Region: tig; TIGR00115 471855001232 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471855001233 uracil-xanthine permease; Region: ncs2; TIGR00801 471855001234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855001235 active site 471855001236 Protein of unknown function (DUF328); Region: DUF328; pfam03883 471855001237 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 471855001238 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471855001239 Na binding site [ion binding]; other site 471855001240 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 471855001241 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471855001242 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 471855001243 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471855001244 dimer interface [polypeptide binding]; other site 471855001245 motif 1; other site 471855001246 active site 471855001247 motif 2; other site 471855001248 motif 3; other site 471855001249 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471855001250 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471855001251 putative tRNA-binding site [nucleotide binding]; other site 471855001252 B3/4 domain; Region: B3_4; pfam03483 471855001253 tRNA synthetase B5 domain; Region: B5; smart00874 471855001254 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 471855001255 dimer interface [polypeptide binding]; other site 471855001256 motif 1; other site 471855001257 motif 3; other site 471855001258 motif 2; other site 471855001259 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471855001260 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471855001261 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471855001262 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855001263 Arginine repressor [Transcription]; Region: ArgR; COG1438 471855001264 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471855001265 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471855001266 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 471855001267 ATP cone domain; Region: ATP-cone; pfam03477 471855001268 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471855001269 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 471855001270 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855001271 FeS/SAM binding site; other site 471855001272 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471855001273 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471855001274 DNA binding residues [nucleotide binding] 471855001275 putative dimer interface [polypeptide binding]; other site 471855001276 Rrf2 family protein; Region: rrf2_super; TIGR00738 471855001277 Transcriptional regulator; Region: Rrf2; cl17282 471855001278 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471855001279 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471855001280 dimer interface [polypeptide binding]; other site 471855001281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855001282 catalytic residue [active] 471855001283 Peptidase C26; Region: Peptidase_C26; pfam07722 471855001284 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 471855001285 catalytic triad [active] 471855001286 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 471855001287 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471855001288 Ligand Binding Site [chemical binding]; other site 471855001289 putative transposase OrfB; Reviewed; Region: PHA02517 471855001290 HTH-like domain; Region: HTH_21; pfam13276 471855001291 Integrase core domain; Region: rve; pfam00665 471855001292 Integrase core domain; Region: rve_2; pfam13333 471855001293 Homeodomain-like domain; Region: HTH_23; pfam13384 471855001294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471855001295 Helix-turn-helix domain; Region: HTH_28; pfam13518 471855001296 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 471855001297 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471855001298 homodimer interface [polypeptide binding]; other site 471855001299 substrate-cofactor binding pocket; other site 471855001300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855001301 catalytic residue [active] 471855001302 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855001303 active site 471855001304 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 471855001305 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 471855001306 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 471855001307 Ligand Binding Site [chemical binding]; other site 471855001308 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 471855001309 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471855001310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855001311 S-adenosylmethionine binding site [chemical binding]; other site 471855001312 FMN binding site [chemical binding]; other site 471855001313 Nitroreductase family; Region: Nitroreductase; pfam00881 471855001314 dimer interface [polypeptide binding]; other site 471855001315 FemAB family; Region: FemAB; pfam02388 471855001316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 471855001317 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471855001318 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471855001319 CoenzymeA binding site [chemical binding]; other site 471855001320 subunit interaction site [polypeptide binding]; other site 471855001321 PHB binding site; other site 471855001322 Cna protein B-type domain; Region: Cna_B; pfam05738 471855001323 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855001324 domain interaction interfaces [polypeptide binding]; other site 471855001325 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855001326 domain interaction interfaces [polypeptide binding]; other site 471855001327 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855001328 domain interaction interfaces [polypeptide binding]; other site 471855001329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471855001330 CoenzymeA binding site [chemical binding]; other site 471855001331 subunit interaction site [polypeptide binding]; other site 471855001332 PHB binding site; other site 471855001333 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 471855001334 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 471855001335 active site 471855001336 metal binding site [ion binding]; metal-binding site 471855001337 Cation efflux family; Region: Cation_efflux; pfam01545 471855001338 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 471855001339 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471855001340 active site 471855001341 catalytic tetrad [active] 471855001342 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855001343 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855001344 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855001345 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855001346 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 471855001347 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471855001348 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 471855001349 putative NAD(P) binding site [chemical binding]; other site 471855001350 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme [General function prediction only]; Region: COG2108 471855001351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855001352 FeS/SAM binding site; other site 471855001353 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855001354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855001355 LysR substrate binding domain; Region: LysR_substrate; pfam03466 471855001356 dimerization interface [polypeptide binding]; other site 471855001357 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855001358 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855001359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001360 molybdopterin cofactor binding site; other site 471855001361 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855001362 molybdopterin cofactor binding site; other site 471855001363 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471855001364 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471855001365 active site 471855001366 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471855001367 classical (c) SDRs; Region: SDR_c; cd05233 471855001368 NAD(P) binding site [chemical binding]; other site 471855001369 active site 471855001370 NlpE N-terminal domain; Region: NlpE; pfam04170 471855001371 Membrane protein of unknown function; Region: DUF360; cl00850 471855001372 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 471855001373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855001374 S-adenosylmethionine binding site [chemical binding]; other site 471855001375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855001376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001377 non-specific DNA binding site [nucleotide binding]; other site 471855001378 salt bridge; other site 471855001379 sequence-specific DNA binding site [nucleotide binding]; other site 471855001380 Predicted ATPase [General function prediction only]; Region: COG3911 471855001381 AAA domain; Region: AAA_28; pfam13521 471855001382 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 471855001383 putative active site; other site 471855001384 putative metal binding residues [ion binding]; other site 471855001385 signature motif; other site 471855001386 putative triphosphate binding site [ion binding]; other site 471855001387 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 471855001388 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 471855001389 4Fe-4S binding domain; Region: Fer4; pfam00037 471855001390 EamA-like transporter family; Region: EamA; pfam00892 471855001391 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855001392 EamA-like transporter family; Region: EamA; pfam00892 471855001393 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 471855001394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001395 non-specific DNA binding site [nucleotide binding]; other site 471855001396 salt bridge; other site 471855001397 sequence-specific DNA binding site [nucleotide binding]; other site 471855001398 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 471855001399 active site 471855001400 homodimer interface [polypeptide binding]; other site 471855001401 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 471855001402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471855001403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855001404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471855001405 transaminase; Validated; Region: PRK07324 471855001406 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855001407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855001408 homodimer interface [polypeptide binding]; other site 471855001409 catalytic residue [active] 471855001410 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 471855001411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855001412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855001413 homodimer interface [polypeptide binding]; other site 471855001414 catalytic residue [active] 471855001415 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 471855001416 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 471855001417 trimer interface [polypeptide binding]; other site 471855001418 putative Zn binding site [ion binding]; other site 471855001419 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471855001420 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 471855001421 active site 471855001422 NTP binding site [chemical binding]; other site 471855001423 metal binding triad [ion binding]; metal-binding site 471855001424 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471855001425 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855001426 Zn2+ binding site [ion binding]; other site 471855001427 Mg2+ binding site [ion binding]; other site 471855001428 CAAX protease self-immunity; Region: Abi; pfam02517 471855001429 EamA-like transporter family; Region: EamA; pfam00892 471855001430 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855001431 EamA-like transporter family; Region: EamA; pfam00892 471855001432 Maf-like protein; Region: Maf; pfam02545 471855001433 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471855001434 active site 471855001435 dimer interface [polypeptide binding]; other site 471855001436 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471855001437 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471855001438 Ligand Binding Site [chemical binding]; other site 471855001439 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855001440 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 471855001441 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 471855001442 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471855001443 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471855001444 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471855001445 oligomerisation interface [polypeptide binding]; other site 471855001446 mobile loop; other site 471855001447 roof hairpin; other site 471855001448 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471855001449 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471855001450 ring oligomerisation interface [polypeptide binding]; other site 471855001451 ATP/Mg binding site [chemical binding]; other site 471855001452 stacking interactions; other site 471855001453 hinge regions; other site 471855001454 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 471855001455 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471855001456 SelR domain; Region: SelR; pfam01641 471855001457 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471855001458 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 471855001459 Na binding site [ion binding]; other site 471855001460 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 471855001461 putative active site [active] 471855001462 putative metal binding site [ion binding]; other site 471855001463 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 471855001464 Cysteine-rich domain; Region: CCG; pfam02754 471855001465 Cysteine-rich domain; Region: CCG; pfam02754 471855001466 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 471855001467 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 471855001468 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 471855001469 Uncharacterized conserved protein [Function unknown]; Region: COG1556 471855001470 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471855001471 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471855001472 NAD(P) binding site [chemical binding]; other site 471855001473 catalytic residues [active] 471855001474 FIST N domain; Region: FIST; pfam08495 471855001475 FIST C domain; Region: FIST_C; pfam10442 471855001476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855001477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855001478 DNA binding residues [nucleotide binding] 471855001479 dimerization interface [polypeptide binding]; other site 471855001480 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855001481 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001482 molybdopterin cofactor binding site; other site 471855001483 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001484 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855001485 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 471855001486 molybdopterin cofactor binding site; other site 471855001487 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001488 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855001489 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 471855001490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001492 PA14 domain; Region: PA14; cl08459 471855001493 Cna protein B-type domain; Region: Cna_B; pfam05738 471855001494 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 471855001495 Cna protein B-type domain; Region: Cna_B; pfam05738 471855001496 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 471855001497 active site 471855001498 catalytic site [active] 471855001499 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 471855001500 active site 471855001501 catalytic site [active] 471855001502 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855001503 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471855001504 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855001506 active site 471855001507 phosphorylation site [posttranslational modification] 471855001508 intermolecular recognition site; other site 471855001509 dimerization interface [polypeptide binding]; other site 471855001510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855001511 DNA binding site [nucleotide binding] 471855001512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855001513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855001514 dimer interface [polypeptide binding]; other site 471855001515 phosphorylation site [posttranslational modification] 471855001516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855001517 ATP binding site [chemical binding]; other site 471855001518 Mg2+ binding site [ion binding]; other site 471855001519 G-X-G motif; other site 471855001520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855001521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855001522 ATP binding site [chemical binding]; other site 471855001523 Mg2+ binding site [ion binding]; other site 471855001524 G-X-G motif; other site 471855001525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855001526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855001527 active site 471855001528 phosphorylation site [posttranslational modification] 471855001529 intermolecular recognition site; other site 471855001530 dimerization interface [polypeptide binding]; other site 471855001531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855001532 DNA binding site [nucleotide binding] 471855001533 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471855001534 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471855001535 Walker A/P-loop; other site 471855001536 ATP binding site [chemical binding]; other site 471855001537 Q-loop/lid; other site 471855001538 ABC transporter signature motif; other site 471855001539 Walker B; other site 471855001540 D-loop; other site 471855001541 H-loop/switch region; other site 471855001542 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471855001543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 471855001544 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471855001545 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 471855001546 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 471855001547 Protease prsW family; Region: PrsW-protease; pfam13367 471855001548 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471855001549 Part of AAA domain; Region: AAA_19; pfam13245 471855001550 Family description; Region: UvrD_C_2; pfam13538 471855001551 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471855001552 putative transposase OrfB; Reviewed; Region: PHA02517 471855001553 HTH-like domain; Region: HTH_21; pfam13276 471855001554 Integrase core domain; Region: rve; pfam00665 471855001555 Integrase core domain; Region: rve_2; pfam13333 471855001556 Homeodomain-like domain; Region: HTH_23; pfam13384 471855001557 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 471855001558 putative FMN binding site [chemical binding]; other site 471855001559 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471855001560 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 471855001561 Uncharacterized conserved protein [Function unknown]; Region: COG1915 471855001562 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 471855001563 Leucine rich repeat variant; Region: LRV; pfam01816 471855001564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855001565 dimerization interface [polypeptide binding]; other site 471855001566 putative DNA binding site [nucleotide binding]; other site 471855001567 putative Zn2+ binding site [ion binding]; other site 471855001568 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 471855001569 metal-binding site [ion binding] 471855001570 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471855001571 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471855001572 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471855001573 Predicted transcriptional regulators [Transcription]; Region: COG1695 471855001574 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471855001575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471855001576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471855001577 ligand binding site [chemical binding]; other site 471855001578 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 471855001579 Ferredoxin [Energy production and conversion]; Region: COG1146 471855001580 4Fe-4S binding domain; Region: Fer4_6; pfam12837 471855001581 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471855001582 carbamate kinase; Reviewed; Region: PRK12686 471855001583 putative substrate binding site [chemical binding]; other site 471855001584 nucleotide binding site [chemical binding]; other site 471855001585 nucleotide binding site [chemical binding]; other site 471855001586 homodimer interface [polypeptide binding]; other site 471855001587 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471855001588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855001589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855001590 LysR substrate binding domain; Region: LysR_substrate; pfam03466 471855001591 dimerization interface [polypeptide binding]; other site 471855001592 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471855001593 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 471855001594 metal binding site [ion binding]; metal-binding site 471855001595 putative dimer interface [polypeptide binding]; other site 471855001596 Predicted membrane protein [Function unknown]; Region: COG1511 471855001597 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471855001598 Predicted membrane protein [Function unknown]; Region: COG1511 471855001599 Golgi transport complex subunit 5; Region: COG5; pfam10392 471855001600 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471855001601 Predicted membrane protein [Function unknown]; Region: COG1511 471855001602 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471855001603 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471855001604 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855001605 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471855001606 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471855001607 trimer interface [polypeptide binding]; other site 471855001608 putative metal binding site [ion binding]; other site 471855001609 Phosphate transporter family; Region: PHO4; pfam01384 471855001610 isocitrate dehydrogenase; Validated; Region: PRK08299 471855001611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855001612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855001613 DNA binding residues [nucleotide binding] 471855001614 dimerization interface [polypeptide binding]; other site 471855001615 Part of AAA domain; Region: AAA_19; pfam13245 471855001616 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471855001617 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855001618 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001619 molybdopterin cofactor binding site; other site 471855001620 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855001621 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001622 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001623 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001624 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 471855001625 putative molybdopterin cofactor binding site; other site 471855001626 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001627 4Fe-4S binding domain; Region: Fer4; pfam00037 471855001628 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855001629 ferredoxin-type protein NapF; Region: napF; TIGR00402 471855001630 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855001631 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 471855001632 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 471855001633 Ferredoxin [Energy production and conversion]; Region: COG1146 471855001634 4Fe-4S binding domain; Region: Fer4; pfam00037 471855001635 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 471855001636 thiosulfate reductase PhsA; Provisional; Region: PRK15488 471855001637 ACT domain-containing protein [General function prediction only]; Region: COG4747 471855001638 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 471855001639 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471855001640 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 471855001641 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855001642 acyl-activating enzyme (AAE) consensus motif; other site 471855001643 AMP binding site [chemical binding]; other site 471855001644 active site 471855001645 CoA binding site [chemical binding]; other site 471855001646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001648 non-specific DNA binding site [nucleotide binding]; other site 471855001649 salt bridge; other site 471855001650 sequence-specific DNA binding site [nucleotide binding]; other site 471855001651 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855001652 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471855001653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471855001654 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471855001655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471855001656 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855001657 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 471855001658 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 471855001659 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 471855001660 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471855001661 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471855001662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471855001663 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471855001664 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 471855001665 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 471855001666 active site 471855001667 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855001668 active site 471855001669 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471855001670 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 471855001671 active site 471855001672 catalytic tetrad [active] 471855001673 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 471855001674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855001675 Flavodoxin domain; Region: Flavodoxin_5; cl17428 471855001676 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001677 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001678 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 471855001679 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855001680 active site 471855001681 metal binding site [ion binding]; metal-binding site 471855001682 homotetramer interface [polypeptide binding]; other site 471855001683 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471855001684 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 471855001685 active site 471855001686 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 471855001687 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 471855001688 Cl binding site [ion binding]; other site 471855001689 oligomer interface [polypeptide binding]; other site 471855001690 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 471855001691 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855001692 ATP binding site [chemical binding]; other site 471855001693 putative Mg++ binding site [ion binding]; other site 471855001694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855001695 nucleotide binding region [chemical binding]; other site 471855001696 ATP-binding site [chemical binding]; other site 471855001697 RQC domain; Region: RQC; pfam09382 471855001698 HRDC domain; Region: HRDC; pfam00570 471855001699 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471855001700 Predicted transcriptional regulators [Transcription]; Region: COG1695 471855001701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855001702 putative DNA binding site [nucleotide binding]; other site 471855001703 putative Zn2+ binding site [ion binding]; other site 471855001704 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 471855001705 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471855001706 phosphate binding site [ion binding]; other site 471855001707 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471855001708 CoenzymeA binding site [chemical binding]; other site 471855001709 subunit interaction site [polypeptide binding]; other site 471855001710 PHB binding site; other site 471855001711 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 471855001712 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 471855001713 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 471855001714 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471855001715 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471855001716 Melibiase; Region: Melibiase; pfam02065 471855001717 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 471855001718 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 471855001719 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855001720 catalytic core [active] 471855001721 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855001722 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 471855001723 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 471855001724 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471855001725 dimerization interface [polypeptide binding]; other site 471855001726 ATP binding site [chemical binding]; other site 471855001727 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471855001728 dimerization interface [polypeptide binding]; other site 471855001729 ATP binding site [chemical binding]; other site 471855001730 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471855001731 putative active site [active] 471855001732 catalytic triad [active] 471855001733 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855001734 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471855001735 active site 471855001736 metal binding site [ion binding]; metal-binding site 471855001737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855001738 S-adenosylmethionine binding site [chemical binding]; other site 471855001739 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 471855001740 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 471855001741 active site 471855001742 catalytic residue [active] 471855001743 dimer interface [polypeptide binding]; other site 471855001744 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 471855001745 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471855001746 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471855001747 shikimate binding site; other site 471855001748 NAD(P) binding site [chemical binding]; other site 471855001749 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 471855001750 active site 471855001751 catalytic residues [active] 471855001752 metal binding site [ion binding]; metal-binding site 471855001753 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471855001754 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471855001755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855001756 Coenzyme A binding pocket [chemical binding]; other site 471855001757 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471855001758 shikimate kinase; Reviewed; Region: aroK; PRK00131 471855001759 ADP binding site [chemical binding]; other site 471855001760 magnesium binding site [ion binding]; other site 471855001761 putative shikimate binding site; other site 471855001762 Double zinc ribbon; Region: DZR; pfam12773 471855001763 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855001764 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855001765 FHA domain; Region: FHA; pfam00498 471855001766 phosphopeptide binding site; other site 471855001767 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 471855001768 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855001769 active site 471855001770 ATP binding site [chemical binding]; other site 471855001771 substrate binding site [chemical binding]; other site 471855001772 activation loop (A-loop); other site 471855001773 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471855001774 Double zinc ribbon; Region: DZR; pfam12773 471855001775 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855001776 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855001777 Double zinc ribbon; Region: DZR; pfam12773 471855001778 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855001779 Double zinc ribbon; Region: DZR; pfam12773 471855001780 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855001781 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 471855001782 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 471855001783 Predicted transcriptional regulators [Transcription]; Region: COG1695 471855001784 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471855001785 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471855001786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471855001787 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471855001788 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471855001789 metal-binding site [ion binding] 471855001790 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 471855001791 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 471855001792 oligomer interface [polypeptide binding]; other site 471855001793 putative active site [active] 471855001794 metal binding site [ion binding]; metal-binding site 471855001795 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 471855001796 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471855001797 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 471855001798 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471855001799 active site 471855001800 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 471855001801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001802 non-specific DNA binding site [nucleotide binding]; other site 471855001803 salt bridge; other site 471855001804 sequence-specific DNA binding site [nucleotide binding]; other site 471855001805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855001806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855001807 non-specific DNA binding site [nucleotide binding]; other site 471855001808 salt bridge; other site 471855001809 sequence-specific DNA binding site [nucleotide binding]; other site 471855001810 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471855001811 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471855001812 HIGH motif; other site 471855001813 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471855001814 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471855001815 active site 471855001816 KMSKS motif; other site 471855001817 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471855001818 tRNA binding surface [nucleotide binding]; other site 471855001819 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471855001820 putative active site [active] 471855001821 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 471855001822 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855001823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855001824 DNA binding residues [nucleotide binding] 471855001825 dimerization interface [polypeptide binding]; other site 471855001826 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855001827 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001828 molybdopterin cofactor binding site; other site 471855001829 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855001830 molybdopterin cofactor binding site; other site 471855001831 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855001833 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001834 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855001835 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855001836 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 471855001837 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471855001838 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471855001839 substrate binding pocket [chemical binding]; other site 471855001840 membrane-bound complex binding site; other site 471855001841 hinge residues; other site 471855001842 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 471855001843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855001844 dimer interface [polypeptide binding]; other site 471855001845 conserved gate region; other site 471855001846 putative PBP binding loops; other site 471855001847 ABC-ATPase subunit interface; other site 471855001848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855001849 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471855001850 Walker A/P-loop; other site 471855001851 ATP binding site [chemical binding]; other site 471855001852 Q-loop/lid; other site 471855001853 ABC transporter signature motif; other site 471855001854 Walker B; other site 471855001855 D-loop; other site 471855001856 H-loop/switch region; other site 471855001857 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471855001858 30S subunit binding site; other site 471855001859 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 471855001860 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 471855001861 active site 471855001862 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 471855001863 Uncharacterized conserved protein [Function unknown]; Region: COG1683 471855001864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855001865 putative DNA binding site [nucleotide binding]; other site 471855001866 putative Zn2+ binding site [ion binding]; other site 471855001867 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855001868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 471855001869 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855001870 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855001871 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471855001872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855001873 S-adenosylmethionine binding site [chemical binding]; other site 471855001874 hypothetical protein; Validated; Region: PRK00110 471855001875 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 471855001876 active site 471855001877 putative DNA-binding cleft [nucleotide binding]; other site 471855001878 dimer interface [polypeptide binding]; other site 471855001879 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471855001880 RuvA N terminal domain; Region: RuvA_N; pfam01330 471855001881 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471855001882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855001883 Walker A motif; other site 471855001884 ATP binding site [chemical binding]; other site 471855001885 Walker B motif; other site 471855001886 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471855001887 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471855001888 DNA-binding site [nucleotide binding]; DNA binding site 471855001889 RNA-binding motif; other site 471855001890 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 471855001891 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 471855001892 catalytic motif [active] 471855001893 Zn binding site [ion binding]; other site 471855001894 RibD C-terminal domain; Region: RibD_C; cl17279 471855001895 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471855001896 Lumazine binding domain; Region: Lum_binding; pfam00677 471855001897 Lumazine binding domain; Region: Lum_binding; pfam00677 471855001898 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 471855001899 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 471855001900 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 471855001901 dimerization interface [polypeptide binding]; other site 471855001902 active site 471855001903 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 471855001904 homopentamer interface [polypeptide binding]; other site 471855001905 active site 471855001906 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471855001907 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471855001908 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 471855001909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471855001910 motif II; other site 471855001911 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 471855001912 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 471855001913 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 471855001914 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 471855001915 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 471855001916 alpha-NAC-related protein; Region: TIGR00264 471855001917 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 471855001918 Protein export membrane protein; Region: SecD_SecF; cl14618 471855001919 Protein export membrane protein; Region: SecD_SecF; pfam02355 471855001920 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471855001921 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471855001922 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855001923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855001924 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 471855001925 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471855001926 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 471855001927 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471855001928 nucleotide binding site [chemical binding]; other site 471855001929 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471855001930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 471855001931 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 471855001932 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 471855001933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 471855001934 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 471855001935 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 471855001936 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 471855001937 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855001938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855001939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855001940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471855001941 dimerization interface [polypeptide binding]; other site 471855001942 hypothetical protein; Validated; Region: PRK07121 471855001943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855001944 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 471855001945 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855001946 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471855001947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855001948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855001949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855001950 dimerization interface [polypeptide binding]; other site 471855001951 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855001952 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855001953 molybdopterin cofactor binding site; other site 471855001954 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855001955 molybdopterin cofactor binding site; other site 471855001956 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855001957 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855001958 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855001959 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471855001960 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 471855001961 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471855001962 Predicted methyltransferases [General function prediction only]; Region: COG0313 471855001963 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471855001964 putative SAM binding site [chemical binding]; other site 471855001965 putative homodimer interface [polypeptide binding]; other site 471855001966 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 471855001967 C-terminal domain interface [polypeptide binding]; other site 471855001968 GSH binding site (G-site) [chemical binding]; other site 471855001969 dimer interface [polypeptide binding]; other site 471855001970 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 471855001971 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 471855001972 dimer interface [polypeptide binding]; other site 471855001973 active site 471855001974 metal binding site [ion binding]; metal-binding site 471855001975 Protein of unknown function DUF45; Region: DUF45; pfam01863 471855001976 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 471855001977 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471855001978 active site 471855001979 HIGH motif; other site 471855001980 KMSKS motif; other site 471855001981 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471855001982 tRNA binding surface [nucleotide binding]; other site 471855001983 anticodon binding site; other site 471855001984 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471855001985 active site 471855001986 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855001987 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855001988 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471855001989 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 471855001990 S-adenosylmethionine binding site [chemical binding]; other site 471855001991 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 471855001992 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 471855001993 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471855001994 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855001995 Walker A/P-loop; other site 471855001996 ATP binding site [chemical binding]; other site 471855001997 Q-loop/lid; other site 471855001998 ABC transporter signature motif; other site 471855001999 Walker B; other site 471855002000 D-loop; other site 471855002001 H-loop/switch region; other site 471855002002 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855002003 Walker A/P-loop; other site 471855002004 ATP binding site [chemical binding]; other site 471855002005 Q-loop/lid; other site 471855002006 ABC transporter signature motif; other site 471855002007 Walker B; other site 471855002008 D-loop; other site 471855002009 H-loop/switch region; other site 471855002010 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855002011 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 471855002012 Carbon starvation protein CstA; Region: CstA; pfam02554 471855002013 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 471855002014 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 471855002015 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471855002016 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855002017 DNA-binding site [nucleotide binding]; DNA binding site 471855002018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855002019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855002020 homodimer interface [polypeptide binding]; other site 471855002021 catalytic residue [active] 471855002022 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855002023 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855002024 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 471855002025 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471855002026 [4Fe-4S] binding site [ion binding]; other site 471855002027 molybdopterin cofactor binding site; other site 471855002028 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 471855002029 molybdopterin cofactor binding site; other site 471855002030 NapD protein; Region: NapD; cl01163 471855002031 4Fe-4S binding domain; Region: Fer4_5; pfam12801 471855002032 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855002033 CcmE; Region: CcmE; cl00994 471855002034 CcmE; Region: CcmE; cl00994 471855002035 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471855002036 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471855002037 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471855002038 Walker A/P-loop; other site 471855002039 ATP binding site [chemical binding]; other site 471855002040 Q-loop/lid; other site 471855002041 ABC transporter signature motif; other site 471855002042 Walker B; other site 471855002043 D-loop; other site 471855002044 H-loop/switch region; other site 471855002045 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 471855002046 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471855002047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471855002048 alanine racemase; Reviewed; Region: alr; PRK00053 471855002049 active site 471855002050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471855002051 dimer interface [polypeptide binding]; other site 471855002052 substrate binding site [chemical binding]; other site 471855002053 catalytic residues [active] 471855002054 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 471855002055 Fe-S cluster binding site [ion binding]; other site 471855002056 active site 471855002057 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471855002058 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471855002059 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471855002060 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471855002061 DNA binding site [nucleotide binding] 471855002062 active site 471855002063 MarR family; Region: MarR_2; pfam12802 471855002064 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471855002065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855002066 NAD(P) binding site [chemical binding]; other site 471855002067 active site 471855002068 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471855002069 ABC1 family; Region: ABC1; pfam03109 471855002070 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471855002071 active site 471855002072 ATP binding site [chemical binding]; other site 471855002073 recombination factor protein RarA; Reviewed; Region: PRK13342 471855002074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855002075 Walker A motif; other site 471855002076 ATP binding site [chemical binding]; other site 471855002077 Walker B motif; other site 471855002078 arginine finger; other site 471855002079 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471855002080 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471855002081 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471855002082 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471855002083 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471855002084 motif 1; other site 471855002085 active site 471855002086 motif 2; other site 471855002087 motif 3; other site 471855002088 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471855002089 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 471855002090 YceG-like family; Region: YceG; pfam02618 471855002091 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 471855002092 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 471855002093 dimerization interface [polypeptide binding]; other site 471855002094 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 471855002095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855002096 active site 471855002097 motif I; other site 471855002098 motif II; other site 471855002099 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471855002100 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 471855002101 Tetramer interface [polypeptide binding]; other site 471855002102 active site 471855002103 FMN-binding site [chemical binding]; other site 471855002104 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 471855002105 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471855002106 ADP binding site [chemical binding]; other site 471855002107 magnesium binding site [ion binding]; other site 471855002108 putative shikimate binding site; other site 471855002109 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 471855002110 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 471855002111 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 471855002112 active site 471855002113 elongation factor P; Validated; Region: PRK00529 471855002114 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471855002115 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471855002116 RNA binding site [nucleotide binding]; other site 471855002117 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471855002118 RNA binding site [nucleotide binding]; other site 471855002119 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 471855002120 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855002121 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855002122 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855002123 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855002124 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855002125 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855002126 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855002127 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855002128 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855002129 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855002130 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855002131 molybdopterin cofactor binding site; other site 471855002132 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855002133 molybdopterin cofactor binding site; other site 471855002134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855002135 Amidinotransferase; Region: Amidinotransf; cl12043 471855002136 pyruvate carboxylase subunit B; Validated; Region: PRK09282 471855002137 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 471855002138 active site 471855002139 catalytic residues [active] 471855002140 metal binding site [ion binding]; metal-binding site 471855002141 homodimer binding site [polypeptide binding]; other site 471855002142 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471855002143 carboxyltransferase (CT) interaction site; other site 471855002144 biotinylation site [posttranslational modification]; other site 471855002145 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471855002146 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471855002147 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471855002148 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471855002149 Asp23 family; Region: Asp23; pfam03780 471855002150 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 471855002151 putative RNA binding site [nucleotide binding]; other site 471855002152 Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647 471855002153 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471855002154 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471855002155 TPP-binding site; other site 471855002156 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471855002157 PYR/PP interface [polypeptide binding]; other site 471855002158 dimer interface [polypeptide binding]; other site 471855002159 TPP binding site [chemical binding]; other site 471855002160 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471855002161 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471855002162 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855002163 RNA binding surface [nucleotide binding]; other site 471855002164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855002165 S-adenosylmethionine binding site [chemical binding]; other site 471855002166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855002167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471855002168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471855002169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855002170 S-adenosylmethionine binding site [chemical binding]; other site 471855002171 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471855002172 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471855002173 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 471855002174 RDD family; Region: RDD; pfam06271 471855002175 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 471855002176 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471855002177 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471855002178 catalytic residues [active] 471855002179 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471855002180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855002181 DNA-binding site [nucleotide binding]; DNA binding site 471855002182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855002183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855002184 homodimer interface [polypeptide binding]; other site 471855002185 catalytic residue [active] 471855002186 Cytochrome c552; Region: Cytochrom_C552; pfam02335 471855002187 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 471855002188 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471855002189 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855002190 catalytic residue [active] 471855002191 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471855002192 rRNA interaction site [nucleotide binding]; other site 471855002193 S8 interaction site; other site 471855002194 putative laminin-1 binding site; other site 471855002195 elongation factor Ts; Provisional; Region: tsf; PRK09377 471855002196 UBA/TS-N domain; Region: UBA; pfam00627 471855002197 Elongation factor TS; Region: EF_TS; pfam00889 471855002198 Elongation factor TS; Region: EF_TS; pfam00889 471855002199 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471855002200 active site 471855002201 catalytic site [active] 471855002202 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 471855002203 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 471855002204 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471855002205 active site 471855002206 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 471855002207 Phage capsid family; Region: Phage_capsid; pfam05065 471855002208 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 471855002209 Phage-related protein [Function unknown]; Region: COG4695; cl01923 471855002210 Phage portal protein; Region: Phage_portal; pfam04860 471855002211 DNA primase, catalytic core; Region: dnaG; TIGR01391 471855002212 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471855002213 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 471855002214 active site 471855002215 metal binding site [ion binding]; metal-binding site 471855002216 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855002217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855002218 non-specific DNA binding site [nucleotide binding]; other site 471855002219 salt bridge; other site 471855002220 sequence-specific DNA binding site [nucleotide binding]; other site 471855002221 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855002222 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471855002223 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471855002224 Int/Topo IB signature motif; other site 471855002225 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471855002226 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471855002227 Transglycosylase; Region: Transgly; pfam00912 471855002228 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471855002229 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471855002230 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 471855002231 Peptidase family U32; Region: Peptidase_U32; pfam01136 471855002232 Collagenase; Region: DUF3656; pfam12392 471855002233 Peptidase family U32; Region: Peptidase_U32; cl03113 471855002234 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471855002235 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471855002236 active site 471855002237 HIGH motif; other site 471855002238 dimer interface [polypeptide binding]; other site 471855002239 KMSKS motif; other site 471855002240 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855002241 RNA binding surface [nucleotide binding]; other site 471855002242 aconitate hydratase; Validated; Region: PRK09277 471855002243 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 471855002244 substrate binding site [chemical binding]; other site 471855002245 ligand binding site [chemical binding]; other site 471855002246 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 471855002247 substrate binding site [chemical binding]; other site 471855002248 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471855002249 23S rRNA interface [nucleotide binding]; other site 471855002250 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471855002251 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471855002252 core dimer interface [polypeptide binding]; other site 471855002253 peripheral dimer interface [polypeptide binding]; other site 471855002254 L10 interface [polypeptide binding]; other site 471855002255 L11 interface [polypeptide binding]; other site 471855002256 putative EF-Tu interaction site [polypeptide binding]; other site 471855002257 putative EF-G interaction site [polypeptide binding]; other site 471855002258 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471855002259 putative deacylase active site [active] 471855002260 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471855002261 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471855002262 Part of AAA domain; Region: AAA_19; pfam13245 471855002263 Family description; Region: UvrD_C_2; pfam13538 471855002264 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471855002265 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 471855002266 additional DNA contacts [nucleotide binding]; other site 471855002267 mismatch recognition site; other site 471855002268 active site 471855002269 zinc binding site [ion binding]; other site 471855002270 DNA intercalation site [nucleotide binding]; other site 471855002271 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 471855002272 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471855002273 dimer interface [polypeptide binding]; other site 471855002274 PYR/PP interface [polypeptide binding]; other site 471855002275 TPP binding site [chemical binding]; other site 471855002276 substrate binding site [chemical binding]; other site 471855002277 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 471855002278 Domain of unknown function; Region: EKR; pfam10371 471855002279 4Fe-4S binding domain; Region: Fer4_6; pfam12837 471855002280 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 471855002281 TPP-binding site [chemical binding]; other site 471855002282 dimer interface [polypeptide binding]; other site 471855002283 RyR domain; Region: RyR; pfam02026 471855002284 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855002285 Double zinc ribbon; Region: DZR; pfam12773 471855002286 TIR domain; Region: TIR_2; pfam13676 471855002287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855002288 non-specific DNA binding site [nucleotide binding]; other site 471855002289 salt bridge; other site 471855002290 sequence-specific DNA binding site [nucleotide binding]; other site 471855002291 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471855002292 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471855002293 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471855002294 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 471855002295 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471855002296 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471855002297 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471855002298 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002299 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002300 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002301 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002302 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002303 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 471855002304 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002305 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 471855002306 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 471855002307 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471855002308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855002309 catalytic residue [active] 471855002310 elongation factor Tu; Reviewed; Region: PRK00049 471855002311 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471855002312 G1 box; other site 471855002313 GEF interaction site [polypeptide binding]; other site 471855002314 GTP/Mg2+ binding site [chemical binding]; other site 471855002315 Switch I region; other site 471855002316 G2 box; other site 471855002317 G3 box; other site 471855002318 Switch II region; other site 471855002319 G4 box; other site 471855002320 G5 box; other site 471855002321 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471855002322 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471855002323 Antibiotic Binding Site [chemical binding]; other site 471855002324 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 471855002325 preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964 471855002326 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471855002327 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471855002328 putative homodimer interface [polypeptide binding]; other site 471855002329 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471855002330 heterodimer interface [polypeptide binding]; other site 471855002331 homodimer interface [polypeptide binding]; other site 471855002332 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471855002333 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471855002334 23S rRNA interface [nucleotide binding]; other site 471855002335 L7/L12 interface [polypeptide binding]; other site 471855002336 putative thiostrepton binding site; other site 471855002337 L25 interface [polypeptide binding]; other site 471855002338 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471855002339 mRNA/rRNA interface [nucleotide binding]; other site 471855002340 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471855002341 active site 471855002342 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471855002343 MviN-like protein; Region: MVIN; pfam03023 471855002344 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 471855002345 ATP-NAD kinase; Region: NAD_kinase; pfam01513 471855002346 CTP synthetase; Validated; Region: pyrG; PRK05380 471855002347 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471855002348 Catalytic site [active] 471855002349 active site 471855002350 UTP binding site [chemical binding]; other site 471855002351 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471855002352 active site 471855002353 putative oxyanion hole; other site 471855002354 catalytic triad [active] 471855002355 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 471855002356 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 471855002357 active site 471855002358 Int/Topo IB signature motif; other site 471855002359 cell division protein MraZ; Reviewed; Region: PRK00326 471855002360 MraZ protein; Region: MraZ; pfam02381 471855002361 MraZ protein; Region: MraZ; pfam02381 471855002362 MraW methylase family; Region: Methyltransf_5; pfam01795 471855002363 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471855002364 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471855002365 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471855002366 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471855002367 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471855002368 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471855002369 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471855002370 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471855002371 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471855002372 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471855002373 Mg++ binding site [ion binding]; other site 471855002374 putative catalytic motif [active] 471855002375 putative substrate binding site [chemical binding]; other site 471855002376 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 471855002377 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471855002378 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471855002379 cell division protein FtsW; Region: ftsW; TIGR02614 471855002380 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471855002381 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471855002382 active site 471855002383 homodimer interface [polypeptide binding]; other site 471855002384 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471855002385 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471855002386 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471855002387 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471855002388 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471855002389 FAD binding domain; Region: FAD_binding_4; pfam01565 471855002390 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471855002391 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471855002392 cell division protein FtsZ; Validated; Region: PRK09330 471855002393 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471855002394 nucleotide binding site [chemical binding]; other site 471855002395 SulA interaction site; other site 471855002396 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471855002397 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471855002398 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471855002399 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471855002400 catalytic residue [active] 471855002401 Protein of unknown function (DUF552); Region: DUF552; pfam04472 471855002402 YGGT family; Region: YGGT; pfam02325 471855002403 DivIVA protein; Region: DivIVA; pfam05103 471855002404 DivIVA domain; Region: DivI1A_domain; TIGR03544 471855002405 Thiamine pyrophosphokinase; Region: TPK; cd07995 471855002406 active site 471855002407 dimerization interface [polypeptide binding]; other site 471855002408 thiamine binding site [chemical binding]; other site 471855002409 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471855002410 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 471855002411 active site 471855002412 NTP binding site [chemical binding]; other site 471855002413 metal binding triad [ion binding]; metal-binding site 471855002414 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471855002415 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 471855002416 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 471855002417 AAA domain; Region: AAA_14; pfam13173 471855002418 Bacterial transcriptional activator domain; Region: BTAD; smart01043 471855002419 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471855002420 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 471855002421 SEC-C motif; Region: SEC-C; pfam02810 471855002422 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471855002423 PCRF domain; Region: PCRF; pfam03462 471855002424 RF-1 domain; Region: RF-1; pfam00472 471855002425 transketolase; Reviewed; Region: PRK05899 471855002426 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471855002427 TPP-binding site [chemical binding]; other site 471855002428 dimer interface [polypeptide binding]; other site 471855002429 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 471855002430 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471855002431 PYR/PP interface [polypeptide binding]; other site 471855002432 dimer interface [polypeptide binding]; other site 471855002433 TPP binding site [chemical binding]; other site 471855002434 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471855002435 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471855002436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855002437 Walker A/P-loop; other site 471855002438 ATP binding site [chemical binding]; other site 471855002439 Q-loop/lid; other site 471855002440 ABC transporter signature motif; other site 471855002441 Walker B; other site 471855002442 D-loop; other site 471855002443 H-loop/switch region; other site 471855002444 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471855002445 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 471855002446 FtsX-like permease family; Region: FtsX; pfam02687 471855002447 C-terminal peptidase (prc); Region: prc; TIGR00225 471855002448 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 471855002449 protein binding site [polypeptide binding]; other site 471855002450 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 471855002451 Catalytic dyad [active] 471855002452 ribonuclease R; Region: RNase_R; TIGR02063 471855002453 RNB domain; Region: RNB; pfam00773 471855002454 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 471855002455 RNA binding site [nucleotide binding]; other site 471855002456 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471855002457 SmpB-tmRNA interface; other site 471855002458 glutamate racemase; Provisional; Region: PRK00865 471855002459 ribonuclease PH; Reviewed; Region: rph; PRK00173 471855002460 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471855002461 hexamer interface [polypeptide binding]; other site 471855002462 active site 471855002463 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471855002464 active site 471855002465 dimerization interface [polypeptide binding]; other site 471855002466 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471855002467 TRAM domain; Region: TRAM; pfam01938 471855002468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855002469 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471855002470 active site 471855002471 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471855002472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855002473 binding surface 471855002474 TPR motif; other site 471855002475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855002476 binding surface 471855002477 TPR motif; other site 471855002478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855002479 binding surface 471855002480 TPR motif; other site 471855002481 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471855002482 active site 471855002483 multimer interface [polypeptide binding]; other site 471855002484 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855002485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855002486 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 471855002487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471855002488 active site 471855002489 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 471855002490 Ligand Binding Site [chemical binding]; other site 471855002491 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471855002492 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471855002493 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471855002494 oxidoreductase; Provisional; Region: PRK10015 471855002495 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 471855002496 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 471855002497 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471855002498 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471855002499 active site 471855002500 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471855002501 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 471855002502 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 471855002503 active site 471855002504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855002505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855002506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471855002507 dimerization interface [polypeptide binding]; other site 471855002508 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 471855002509 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 471855002510 acyl-activating enzyme (AAE) consensus motif; other site 471855002511 putative AMP binding site [chemical binding]; other site 471855002512 putative active site [active] 471855002513 putative CoA binding site [chemical binding]; other site 471855002514 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 471855002515 CoA-transferase family III; Region: CoA_transf_3; pfam02515 471855002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855002517 putative substrate translocation pore; other site 471855002518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855002519 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 471855002520 hypothetical protein; Provisional; Region: PRK14641 471855002521 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471855002522 putative oligomer interface [polypeptide binding]; other site 471855002523 putative RNA binding site [nucleotide binding]; other site 471855002524 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471855002525 NusA N-terminal domain; Region: NusA_N; pfam08529 471855002526 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471855002527 RNA binding site [nucleotide binding]; other site 471855002528 homodimer interface [polypeptide binding]; other site 471855002529 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471855002530 G-X-X-G motif; other site 471855002531 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471855002532 G-X-X-G motif; other site 471855002533 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471855002534 translation initiation factor IF-2; Region: IF-2; TIGR00487 471855002535 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471855002536 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471855002537 G1 box; other site 471855002538 putative GEF interaction site [polypeptide binding]; other site 471855002539 GTP/Mg2+ binding site [chemical binding]; other site 471855002540 Switch I region; other site 471855002541 G2 box; other site 471855002542 G3 box; other site 471855002543 Switch II region; other site 471855002544 G4 box; other site 471855002545 G5 box; other site 471855002546 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471855002547 Translation-initiation factor 2; Region: IF-2; pfam11987 471855002548 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471855002549 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471855002550 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 471855002551 DHH family; Region: DHH; pfam01368 471855002552 DHHA1 domain; Region: DHHA1; pfam02272 471855002553 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 471855002554 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471855002555 RNA binding site [nucleotide binding]; other site 471855002556 active site 471855002557 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 471855002558 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471855002559 active site 471855002560 Riboflavin kinase; Region: Flavokinase; pfam01687 471855002561 DNA primase; Validated; Region: dnaG; PRK05667 471855002562 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471855002563 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471855002564 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471855002565 active site 471855002566 metal binding site [ion binding]; metal-binding site 471855002567 interdomain interaction site; other site 471855002568 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471855002569 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471855002570 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 471855002571 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855002572 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471855002573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855002574 DNA binding residues [nucleotide binding] 471855002575 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471855002576 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471855002577 TfoX N-terminal domain; Region: TfoX_N; pfam04993 471855002578 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471855002579 DNA-binding interface [nucleotide binding]; DNA binding site 471855002580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 471855002581 DNA binding residues [nucleotide binding] 471855002582 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 471855002583 FOG: CBS domain [General function prediction only]; Region: COG0517 471855002584 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471855002585 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471855002586 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855002587 active site 471855002588 ATP binding site [chemical binding]; other site 471855002589 substrate binding site [chemical binding]; other site 471855002590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471855002591 substrate binding site [chemical binding]; other site 471855002592 activation loop (A-loop); other site 471855002593 activation loop (A-loop); other site 471855002594 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 471855002595 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471855002596 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855002597 Rubredoxin [Energy production and conversion]; Region: COG1773 471855002598 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 471855002599 iron binding site [ion binding]; other site 471855002600 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471855002601 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471855002602 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471855002603 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471855002604 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855002605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855002606 ABC transporter; Region: ABC_tran_2; pfam12848 471855002607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855002608 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471855002609 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 471855002610 Peptidase family M50; Region: Peptidase_M50; pfam02163 471855002611 active site 471855002612 putative substrate binding region [chemical binding]; other site 471855002613 ScpA/B protein; Region: ScpA_ScpB; cl00598 471855002614 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 471855002615 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471855002616 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855002617 RNA binding surface [nucleotide binding]; other site 471855002618 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471855002619 active site 471855002620 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471855002621 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471855002622 hinge; other site 471855002623 active site 471855002624 cytidylate kinase; Provisional; Region: cmk; PRK00023 471855002625 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471855002626 CMP-binding site; other site 471855002627 The sites determining sugar specificity; other site 471855002628 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471855002629 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471855002630 putative acyl-acceptor binding pocket; other site 471855002631 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 471855002632 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471855002633 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471855002634 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 471855002635 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 471855002636 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 471855002637 Protein of unknown function (DUF512); Region: DUF512; pfam04459 471855002638 GTP-binding protein Der; Reviewed; Region: PRK00093 471855002639 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471855002640 G1 box; other site 471855002641 GTP/Mg2+ binding site [chemical binding]; other site 471855002642 Switch I region; other site 471855002643 G2 box; other site 471855002644 Switch II region; other site 471855002645 G3 box; other site 471855002646 G4 box; other site 471855002647 G5 box; other site 471855002648 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471855002649 G1 box; other site 471855002650 GTP/Mg2+ binding site [chemical binding]; other site 471855002651 Switch I region; other site 471855002652 G2 box; other site 471855002653 G3 box; other site 471855002654 Switch II region; other site 471855002655 G4 box; other site 471855002656 G5 box; other site 471855002657 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 471855002658 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471855002659 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471855002660 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471855002661 Double zinc ribbon; Region: DZR; pfam12773 471855002662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855002663 active site 471855002664 HIRAN domain; Region: HIRAN; cl07418 471855002665 Predicted permeases [General function prediction only]; Region: COG0679 471855002666 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 471855002667 RNAase interaction site [polypeptide binding]; other site 471855002668 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 471855002669 active site clefts [active] 471855002670 zinc binding site [ion binding]; other site 471855002671 dimer interface [polypeptide binding]; other site 471855002672 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 471855002673 active site 471855002674 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471855002675 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471855002676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471855002677 active site 471855002678 Septum formation initiator; Region: DivIC; cl17659 471855002679 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 471855002680 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471855002681 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855002682 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855002683 4Fe-4S binding domain; Region: Fer4; pfam00037 471855002684 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471855002685 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471855002686 HIGH motif; other site 471855002687 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471855002688 active site 471855002689 KMSKS motif; other site 471855002690 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 471855002691 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 471855002692 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471855002693 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471855002694 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471855002695 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471855002696 primosome assembly protein PriA; Validated; Region: PRK05580 471855002697 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855002698 ATP binding site [chemical binding]; other site 471855002699 putative Mg++ binding site [ion binding]; other site 471855002700 helicase superfamily c-terminal domain; Region: HELICc; smart00490 471855002701 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471855002702 active site 471855002703 catalytic residues [active] 471855002704 metal binding site [ion binding]; metal-binding site 471855002705 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471855002706 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471855002707 putative active site [active] 471855002708 substrate binding site [chemical binding]; other site 471855002709 putative cosubstrate binding site; other site 471855002710 catalytic site [active] 471855002711 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471855002712 substrate binding site [chemical binding]; other site 471855002713 NusB family; Region: NusB; pfam01029 471855002714 putative RNA binding site [nucleotide binding]; other site 471855002715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855002716 S-adenosylmethionine binding site [chemical binding]; other site 471855002717 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471855002718 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471855002719 DNA binding site [nucleotide binding] 471855002720 active site 471855002721 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 471855002722 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471855002723 substrate binding site [chemical binding]; other site 471855002724 hexamer interface [polypeptide binding]; other site 471855002725 metal binding site [ion binding]; metal-binding site 471855002726 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471855002727 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471855002728 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855002729 catalytic residue [active] 471855002730 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471855002731 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471855002732 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471855002733 Putative zinc ribbon domain; Region: DUF164; pfam02591 471855002734 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471855002735 Asp23 family; Region: Asp23; pfam03780 471855002736 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 471855002737 DAK2 domain; Region: Dak2; pfam02734 471855002738 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471855002739 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471855002740 generic binding surface II; other site 471855002741 ssDNA binding site; other site 471855002742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855002743 ATP binding site [chemical binding]; other site 471855002744 putative Mg++ binding site [ion binding]; other site 471855002745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855002746 nucleotide binding region [chemical binding]; other site 471855002747 ATP-binding site [chemical binding]; other site 471855002748 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 471855002749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855002750 S-adenosylmethionine binding site [chemical binding]; other site 471855002751 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471855002752 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471855002753 active site 471855002754 (T/H)XGH motif; other site 471855002755 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 471855002756 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471855002757 putative phosphate acyltransferase; Provisional; Region: PRK05331 471855002758 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 471855002759 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471855002760 dimerization interface [polypeptide binding]; other site 471855002761 active site 471855002762 metal binding site [ion binding]; metal-binding site 471855002763 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471855002764 dsRNA binding site [nucleotide binding]; other site 471855002765 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471855002766 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471855002767 Walker A/P-loop; other site 471855002768 ATP binding site [chemical binding]; other site 471855002769 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471855002770 ABC transporter signature motif; other site 471855002771 Walker B; other site 471855002772 D-loop; other site 471855002773 H-loop/switch region; other site 471855002774 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471855002775 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 471855002776 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471855002777 P loop; other site 471855002778 GTP binding site [chemical binding]; other site 471855002779 signal recognition particle protein; Provisional; Region: PRK10867 471855002780 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471855002781 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471855002782 P loop; other site 471855002783 GTP binding site [chemical binding]; other site 471855002784 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471855002785 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471855002786 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471855002787 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471855002788 Phosphoglycerate kinase; Region: PGK; pfam00162 471855002789 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471855002790 substrate binding site [chemical binding]; other site 471855002791 hinge regions; other site 471855002792 ADP binding site [chemical binding]; other site 471855002793 catalytic site [active] 471855002794 triosephosphate isomerase; Provisional; Region: PRK14567 471855002795 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471855002796 substrate binding site [chemical binding]; other site 471855002797 dimer interface [polypeptide binding]; other site 471855002798 catalytic triad [active] 471855002799 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 471855002800 prephenate dehydrogenase; Validated; Region: PRK08507 471855002801 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471855002802 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471855002803 Tetramer interface [polypeptide binding]; other site 471855002804 active site 471855002805 FMN-binding site [chemical binding]; other site 471855002806 Chorismate mutase type II; Region: CM_2; smart00830 471855002807 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 471855002808 Prephenate dehydratase; Region: PDT; pfam00800 471855002809 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471855002810 putative L-Phe binding site [chemical binding]; other site 471855002811 Preprotein translocase SecG subunit; Region: SecG; pfam03840 471855002812 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 471855002813 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 471855002814 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471855002815 active site 471855002816 dimer interface [polypeptide binding]; other site 471855002817 metal binding site [ion binding]; metal-binding site 471855002818 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471855002819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855002820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855002821 DNA binding residues [nucleotide binding] 471855002822 SLBB domain; Region: SLBB; pfam10531 471855002823 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471855002824 Helix-hairpin-helix motif; Region: HHH; pfam00633 471855002825 Competence protein; Region: Competence; pfam03772 471855002826 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 471855002827 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 471855002828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855002829 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 471855002830 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471855002831 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471855002832 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 471855002833 G1 box; other site 471855002834 GTP/Mg2+ binding site [chemical binding]; other site 471855002835 Switch I region; other site 471855002836 G2 box; other site 471855002837 G3 box; other site 471855002838 Switch II region; other site 471855002839 G4 box; other site 471855002840 G5 box; other site 471855002841 GTP-binding protein LepA; Provisional; Region: PRK05433 471855002842 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471855002843 G1 box; other site 471855002844 putative GEF interaction site [polypeptide binding]; other site 471855002845 GTP/Mg2+ binding site [chemical binding]; other site 471855002846 Switch I region; other site 471855002847 G2 box; other site 471855002848 G3 box; other site 471855002849 Switch II region; other site 471855002850 G4 box; other site 471855002851 G5 box; other site 471855002852 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 471855002853 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471855002854 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471855002855 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 471855002856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855002857 FeS/SAM binding site; other site 471855002858 HemN C-terminal domain; Region: HemN_C; pfam06969 471855002859 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471855002860 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471855002861 FMN binding site [chemical binding]; other site 471855002862 active site 471855002863 catalytic residues [active] 471855002864 substrate binding site [chemical binding]; other site 471855002865 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471855002866 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 471855002867 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 471855002868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471855002869 HSP70 interaction site [polypeptide binding]; other site 471855002870 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471855002871 Zn binding sites [ion binding]; other site 471855002872 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471855002873 dimer interface [polypeptide binding]; other site 471855002874 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 471855002875 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471855002876 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855002877 FeS/SAM binding site; other site 471855002878 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 471855002879 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 471855002880 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471855002881 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471855002882 RNA/DNA hybrid binding site [nucleotide binding]; other site 471855002883 active site 471855002884 hypothetical protein; Reviewed; Region: PRK12497 471855002885 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471855002886 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 471855002887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855002888 Walker A motif; other site 471855002889 ATP binding site [chemical binding]; other site 471855002890 Walker B motif; other site 471855002891 arginine finger; other site 471855002892 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 471855002893 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471855002894 DNA protecting protein DprA; Region: dprA; TIGR00732 471855002895 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 471855002896 Glucose inhibited division protein A; Region: GIDA; pfam01134 471855002897 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855002898 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 471855002899 active site 471855002900 DNA binding site [nucleotide binding] 471855002901 Int/Topo IB signature motif; other site 471855002902 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471855002903 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471855002904 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471855002905 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471855002906 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471855002907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855002908 Coenzyme A binding pocket [chemical binding]; other site 471855002909 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 471855002910 dimer interface [polypeptide binding]; other site 471855002911 active site 471855002912 metal binding site [ion binding]; metal-binding site 471855002913 glutathione binding site [chemical binding]; other site 471855002914 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471855002915 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 471855002916 putative efflux protein, MATE family; Region: matE; TIGR00797 471855002917 glutamate dehydrogenase; Provisional; Region: PRK09414 471855002918 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471855002919 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 471855002920 NAD(P) binding site [chemical binding]; other site 471855002921 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855002922 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 471855002923 RNA/DNA hybrid binding site [nucleotide binding]; other site 471855002924 active site 471855002925 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471855002926 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855002927 binding surface 471855002928 TPR motif; other site 471855002929 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 471855002930 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 471855002931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 471855002932 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 471855002933 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471855002934 serine/threonine transporter SstT; Provisional; Region: PRK13628 471855002935 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471855002936 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855002937 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471855002938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855002939 Walker A/P-loop; other site 471855002940 ATP binding site [chemical binding]; other site 471855002941 Q-loop/lid; other site 471855002942 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 471855002943 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 471855002944 ABC transporter signature motif; other site 471855002945 Walker B; other site 471855002946 D-loop; other site 471855002947 H-loop/switch region; other site 471855002948 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 471855002949 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471855002950 active site 471855002951 metal binding site [ion binding]; metal-binding site 471855002952 DNA binding site [nucleotide binding] 471855002953 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 471855002954 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471855002955 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471855002956 GIY-YIG motif/motif A; other site 471855002957 active site 471855002958 catalytic site [active] 471855002959 putative DNA binding site [nucleotide binding]; other site 471855002960 metal binding site [ion binding]; metal-binding site 471855002961 UvrB/uvrC motif; Region: UVR; pfam02151 471855002962 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471855002963 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 471855002964 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471855002965 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 471855002966 phosphate binding site [ion binding]; other site 471855002967 putative substrate binding pocket [chemical binding]; other site 471855002968 dimer interface [polypeptide binding]; other site 471855002969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471855002970 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471855002971 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471855002972 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855002973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855002974 homodimer interface [polypeptide binding]; other site 471855002975 catalytic residue [active] 471855002976 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471855002977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855002978 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471855002979 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471855002980 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471855002981 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471855002982 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 471855002983 Helix-turn-helix domain; Region: HTH_25; pfam13413 471855002984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 471855002985 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 471855002986 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 471855002987 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471855002988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855002989 FeS/SAM binding site; other site 471855002990 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471855002991 Competence-damaged protein; Region: CinA; pfam02464 471855002992 recombinase A; Provisional; Region: recA; PRK09354 471855002993 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471855002994 hexamer interface [polypeptide binding]; other site 471855002995 Walker A motif; other site 471855002996 ATP binding site [chemical binding]; other site 471855002997 Walker B motif; other site 471855002998 recombination regulator RecX; Reviewed; Region: recX; PRK00117 471855002999 phosphodiesterase; Provisional; Region: PRK12704 471855003000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855003001 Zn2+ binding site [ion binding]; other site 471855003002 Mg2+ binding site [ion binding]; other site 471855003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855003004 ATP binding site [chemical binding]; other site 471855003005 Mg2+ binding site [ion binding]; other site 471855003006 G-X-G motif; other site 471855003007 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 471855003008 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 471855003009 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471855003010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003011 FeS/SAM binding site; other site 471855003012 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471855003013 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471855003014 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471855003015 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471855003016 HflX GTPase family; Region: HflX; cd01878 471855003017 G1 box; other site 471855003018 GTP/Mg2+ binding site [chemical binding]; other site 471855003019 Switch I region; other site 471855003020 G2 box; other site 471855003021 G3 box; other site 471855003022 Switch II region; other site 471855003023 G4 box; other site 471855003024 G5 box; other site 471855003025 LexA repressor; Validated; Region: PRK00215 471855003026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855003027 putative DNA binding site [nucleotide binding]; other site 471855003028 putative Zn2+ binding site [ion binding]; other site 471855003029 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471855003030 Catalytic site [active] 471855003031 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471855003032 ATP cone domain; Region: ATP-cone; pfam03477 471855003033 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471855003034 trimer interface [polypeptide binding]; other site 471855003035 active site 471855003036 EDD domain protein, DegV family; Region: DegV; TIGR00762 471855003037 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471855003038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471855003039 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855003040 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471855003041 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471855003042 CoenzymeA binding site [chemical binding]; other site 471855003043 subunit interaction site [polypeptide binding]; other site 471855003044 PHB binding site; other site 471855003045 methionine aminopeptidase; Provisional; Region: PRK12318 471855003046 SEC-C motif; Region: SEC-C; pfam02810 471855003047 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471855003048 active site 471855003049 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 471855003050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471855003051 active site 471855003052 HIGH motif; other site 471855003053 nucleotide binding site [chemical binding]; other site 471855003054 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471855003055 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471855003056 active site 471855003057 KMSKS motif; other site 471855003058 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 471855003059 tRNA binding surface [nucleotide binding]; other site 471855003060 anticodon binding site; other site 471855003061 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471855003062 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 471855003063 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 471855003064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855003065 RNA binding surface [nucleotide binding]; other site 471855003066 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471855003067 active site 471855003068 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471855003069 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855003070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855003071 homodimer interface [polypeptide binding]; other site 471855003072 catalytic residue [active] 471855003073 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471855003074 16S/18S rRNA binding site [nucleotide binding]; other site 471855003075 S13e-L30e interaction site [polypeptide binding]; other site 471855003076 25S rRNA binding site [nucleotide binding]; other site 471855003077 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 471855003078 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 471855003079 RNase E interface [polypeptide binding]; other site 471855003080 trimer interface [polypeptide binding]; other site 471855003081 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471855003082 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471855003083 RNase E interface [polypeptide binding]; other site 471855003084 trimer interface [polypeptide binding]; other site 471855003085 active site 471855003086 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471855003087 putative nucleic acid binding region [nucleotide binding]; other site 471855003088 G-X-X-G motif; other site 471855003089 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471855003090 RNA binding site [nucleotide binding]; other site 471855003091 domain interface; other site 471855003092 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 471855003093 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471855003094 KH domain; Region: KH_4; pfam13083 471855003095 G-X-X-G motif; other site 471855003096 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471855003097 RimM N-terminal domain; Region: RimM; pfam01782 471855003098 PRC-barrel domain; Region: PRC; pfam05239 471855003099 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471855003100 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471855003101 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471855003102 Catalytic site [active] 471855003103 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 471855003104 dimer interface [polypeptide binding]; other site 471855003105 motif 1; other site 471855003106 active site 471855003107 motif 2; other site 471855003108 motif 3; other site 471855003109 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 471855003110 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471855003111 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 471855003112 pyruvate phosphate dikinase; Provisional; Region: PRK09279 471855003113 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471855003114 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471855003115 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471855003116 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 471855003117 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 471855003118 CAAX protease self-immunity; Region: Abi; cl00558 471855003119 cobalt transport protein CbiM; Provisional; Region: PRK07331 471855003120 cobalt transport protein CbiM; Provisional; Region: PRK11909 471855003121 PDGLE domain; Region: PDGLE; pfam13190 471855003122 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855003123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855003124 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471855003125 Walker A/P-loop; other site 471855003126 ATP binding site [chemical binding]; other site 471855003127 Q-loop/lid; other site 471855003128 ABC transporter signature motif; other site 471855003129 Walker B; other site 471855003130 D-loop; other site 471855003131 H-loop/switch region; other site 471855003132 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 471855003133 hypothetical protein; Provisional; Region: PRK00955 471855003134 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 471855003135 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 471855003136 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 471855003137 putative metal binding site [ion binding]; other site 471855003138 Uncharacterized conserved protein [Function unknown]; Region: COG1432 471855003139 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 471855003140 PIN domain; Region: PIN_3; pfam13470 471855003141 PrcB C-terminal; Region: PrcB_C; pfam14343 471855003142 monoglyceride lipase; Provisional; Region: PHA02857 471855003143 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471855003144 Predicted acyl esterases [General function prediction only]; Region: COG2936 471855003145 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471855003146 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471855003147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855003148 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 471855003149 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855003150 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471855003151 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855003152 4Fe-4S binding domain; Region: Fer4; cl02805 471855003153 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855003154 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855003155 molybdopterin cofactor binding site; other site 471855003156 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855003157 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855003158 molybdopterin cofactor binding site; other site 471855003159 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855003160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855003161 active site 471855003162 phosphorylation site [posttranslational modification] 471855003163 intermolecular recognition site; other site 471855003164 dimerization interface [polypeptide binding]; other site 471855003165 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855003166 DNA binding site [nucleotide binding] 471855003167 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 471855003168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471855003169 dimerization interface [polypeptide binding]; other site 471855003170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855003171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855003172 dimer interface [polypeptide binding]; other site 471855003173 phosphorylation site [posttranslational modification] 471855003174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855003175 ATP binding site [chemical binding]; other site 471855003176 Mg2+ binding site [ion binding]; other site 471855003177 G-X-G motif; other site 471855003178 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855003179 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855003180 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855003181 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855003182 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855003183 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855003184 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 471855003185 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471855003186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855003187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855003188 DNA binding residues [nucleotide binding] 471855003189 Putative zinc-finger; Region: zf-HC2; pfam13490 471855003190 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471855003191 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 471855003192 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471855003193 homodimer interface [polypeptide binding]; other site 471855003194 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471855003195 active site 471855003196 TDP-binding site; other site 471855003197 acceptor substrate-binding pocket; other site 471855003198 DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077 471855003199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 471855003200 TM2 domain; Region: TM2; pfam05154 471855003201 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471855003202 active site 471855003203 8-oxo-dGMP binding site [chemical binding]; other site 471855003204 nudix motif; other site 471855003205 metal binding site [ion binding]; metal-binding site 471855003206 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 471855003207 PLD-like domain; Region: PLDc_2; pfam13091 471855003208 putative homodimer interface [polypeptide binding]; other site 471855003209 putative active site [active] 471855003210 catalytic site [active] 471855003211 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471855003212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855003213 ATP binding site [chemical binding]; other site 471855003214 putative Mg++ binding site [ion binding]; other site 471855003215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855003216 nucleotide binding region [chemical binding]; other site 471855003217 ATP-binding site [chemical binding]; other site 471855003218 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 471855003219 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 471855003220 pentamer interface [polypeptide binding]; other site 471855003221 dodecaamer interface [polypeptide binding]; other site 471855003222 LytTr DNA-binding domain; Region: LytTR; smart00850 471855003223 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855003224 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855003225 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855003226 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 471855003227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855003228 salt bridge; other site 471855003229 non-specific DNA binding site [nucleotide binding]; other site 471855003230 sequence-specific DNA binding site [nucleotide binding]; other site 471855003231 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 471855003232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855003233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855003234 DNA binding residues [nucleotide binding] 471855003235 dimerization interface [polypeptide binding]; other site 471855003236 siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470 471855003237 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 471855003238 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 471855003239 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 471855003240 tRNA; other site 471855003241 putative tRNA binding site [nucleotide binding]; other site 471855003242 putative NADP binding site [chemical binding]; other site 471855003243 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471855003244 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471855003245 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 471855003246 domain interfaces; other site 471855003247 active site 471855003248 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471855003249 active site 471855003250 SAM binding site [chemical binding]; other site 471855003251 homodimer interface [polypeptide binding]; other site 471855003252 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 471855003253 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471855003254 active site 471855003255 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 471855003256 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003257 FeS/SAM binding site; other site 471855003258 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471855003259 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 471855003260 dimer interface [polypeptide binding]; other site 471855003261 active site 471855003262 Schiff base residues; other site 471855003263 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 471855003264 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003265 FeS/SAM binding site; other site 471855003266 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471855003267 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471855003268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471855003269 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471855003270 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471855003271 inhibitor-cofactor binding pocket; inhibition site 471855003272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855003273 catalytic residue [active] 471855003274 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471855003275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471855003276 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 471855003277 trigger factor; Region: tig; TIGR00115 471855003278 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471855003279 SAP domain; Region: SAP; pfam02037 471855003280 Clp protease; Region: CLP_protease; pfam00574 471855003281 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471855003282 oligomer interface [polypeptide binding]; other site 471855003283 active site residues [active] 471855003284 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471855003285 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471855003286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855003287 Walker A motif; other site 471855003288 ATP binding site [chemical binding]; other site 471855003289 Walker B motif; other site 471855003290 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471855003291 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 471855003292 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471855003293 active site 471855003294 HIGH motif; other site 471855003295 nucleotide binding site [chemical binding]; other site 471855003296 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471855003297 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 471855003298 active site 471855003299 KMSKS motif; other site 471855003300 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471855003301 tRNA binding surface [nucleotide binding]; other site 471855003302 anticodon binding site; other site 471855003303 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 471855003304 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471855003305 Double zinc ribbon; Region: DZR; pfam12773 471855003306 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 471855003307 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 471855003308 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471855003309 Recombination protein O N terminal; Region: RecO_N; pfam11967 471855003310 Recombination protein O C terminal; Region: RecO_C; pfam02565 471855003311 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 471855003312 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 471855003313 nickel binding site [ion binding]; other site 471855003314 Predicted membrane protein [Function unknown]; Region: COG1511 471855003315 Predicted membrane protein [Function unknown]; Region: COG1511 471855003316 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471855003317 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 471855003318 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471855003319 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 471855003320 NADP binding site [chemical binding]; other site 471855003321 active site 471855003322 putative substrate binding site [chemical binding]; other site 471855003323 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471855003324 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855003325 active site 471855003326 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471855003327 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471855003328 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471855003329 dihydroorotase; Validated; Region: pyrC; PRK09357 471855003330 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471855003331 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471855003332 active site 471855003333 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 471855003334 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 471855003335 FAD binding pocket [chemical binding]; other site 471855003336 FAD binding motif [chemical binding]; other site 471855003337 phosphate binding motif [ion binding]; other site 471855003338 beta-alpha-beta structure motif; other site 471855003339 NAD binding pocket [chemical binding]; other site 471855003340 Iron coordination center [ion binding]; other site 471855003341 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 471855003342 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 471855003343 heterodimer interface [polypeptide binding]; other site 471855003344 active site 471855003345 FMN binding site [chemical binding]; other site 471855003346 homodimer interface [polypeptide binding]; other site 471855003347 substrate binding site [chemical binding]; other site 471855003348 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471855003349 active site 471855003350 dimer interface [polypeptide binding]; other site 471855003351 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 471855003352 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471855003353 catalytic site [active] 471855003354 G-X2-G-X-G-K; other site 471855003355 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 471855003356 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 471855003357 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 471855003358 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 471855003359 Ligand Binding Site [chemical binding]; other site 471855003360 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855003361 Prion/Doppel alpha-helical domain; Region: Prion; cl02493 471855003362 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 471855003363 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471855003364 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471855003365 Rubredoxin; Region: Rubredoxin; pfam00301 471855003366 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 471855003367 Rubrerythrin [Energy production and conversion]; Region: COG1592 471855003368 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 471855003369 binuclear metal center [ion binding]; other site 471855003370 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 471855003371 iron binding site [ion binding]; other site 471855003372 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855003373 domain interaction interfaces [polypeptide binding]; other site 471855003374 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855003375 domain interaction interfaces [polypeptide binding]; other site 471855003376 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855003377 domain interaction interfaces [polypeptide binding]; other site 471855003378 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855003379 domain interaction interfaces [polypeptide binding]; other site 471855003380 Histidine kinase; Region: His_kinase; pfam06580 471855003381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855003382 ATP binding site [chemical binding]; other site 471855003383 Mg2+ binding site [ion binding]; other site 471855003384 G-X-G motif; other site 471855003385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855003386 Response regulator receiver domain; Region: Response_reg; pfam00072 471855003387 active site 471855003388 phosphorylation site [posttranslational modification] 471855003389 intermolecular recognition site; other site 471855003390 dimerization interface [polypeptide binding]; other site 471855003391 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 471855003392 DNA binding site [nucleotide binding] 471855003393 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 471855003394 amphipathic channel; other site 471855003395 Asn-Pro-Ala signature motifs; other site 471855003396 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471855003397 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471855003398 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471855003399 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 471855003400 Walker A/P-loop; other site 471855003401 ATP binding site [chemical binding]; other site 471855003402 Q-loop/lid; other site 471855003403 ABC transporter signature motif; other site 471855003404 Walker B; other site 471855003405 D-loop; other site 471855003406 H-loop/switch region; other site 471855003407 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471855003408 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471855003409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855003410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855003411 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 471855003412 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 471855003413 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 471855003414 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471855003415 catalytic site [active] 471855003416 putative active site [active] 471855003417 putative substrate binding site [chemical binding]; other site 471855003418 HRDC domain; Region: HRDC; pfam00570 471855003419 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 471855003420 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471855003421 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471855003422 generic binding surface II; other site 471855003423 generic binding surface I; other site 471855003424 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471855003425 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471855003426 nucleotide binding site/active site [active] 471855003427 HIT family signature motif; other site 471855003428 catalytic residue [active] 471855003429 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 471855003430 propionate/acetate kinase; Provisional; Region: PRK12379 471855003431 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 471855003432 nucleotide binding site/active site [active] 471855003433 HIT family signature motif; other site 471855003434 catalytic residue [active] 471855003435 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471855003436 LytTr DNA-binding domain; Region: LytTR; smart00850 471855003437 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 471855003438 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471855003439 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471855003440 active site 471855003441 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855003442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003443 FeS/SAM binding site; other site 471855003444 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 471855003445 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 471855003446 active site 471855003447 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 471855003448 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 2; Region: NGN_Bact_2; cd09889 471855003449 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 471855003450 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471855003451 heterodimer interface [polypeptide binding]; other site 471855003452 homodimer interface [polypeptide binding]; other site 471855003453 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471855003454 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 471855003455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471855003456 active site 471855003457 LicD family; Region: LicD; pfam04991 471855003458 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 471855003459 LicD family; Region: LicD; pfam04991 471855003460 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 471855003461 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 471855003462 LicD family; Region: LicD; pfam04991 471855003463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855003464 non-specific DNA binding site [nucleotide binding]; other site 471855003465 salt bridge; other site 471855003466 sequence-specific DNA binding site [nucleotide binding]; other site 471855003467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471855003468 active site 471855003469 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471855003470 substrate binding site; other site 471855003471 dimer interface; other site 471855003472 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes [Cell envelope biogenesis, outer membrane]; Region: LicC; COG4750 471855003473 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471855003474 active site 471855003475 substrate binding site [chemical binding]; other site 471855003476 ATP binding site [chemical binding]; other site 471855003477 Phosphotransferase enzyme family; Region: APH; pfam01636 471855003478 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855003479 catalytic core [active] 471855003480 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 471855003481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855003482 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855003483 DNA binding residues [nucleotide binding] 471855003484 putrescine carbamoyltransferase; Provisional; Region: PRK02255 471855003485 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471855003486 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471855003487 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 471855003488 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471855003489 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 471855003490 carbamate kinase; Reviewed; Region: PRK12686 471855003491 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471855003492 putative substrate binding site [chemical binding]; other site 471855003493 nucleotide binding site [chemical binding]; other site 471855003494 nucleotide binding site [chemical binding]; other site 471855003495 homodimer interface [polypeptide binding]; other site 471855003496 AAA domain; Region: AAA_21; pfam13304 471855003497 AAA domain; Region: AAA_21; pfam13304 471855003498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855003499 ABC transporter signature motif; other site 471855003500 Walker B; other site 471855003501 D-loop; other site 471855003502 H-loop/switch region; other site 471855003503 RloB-like protein; Region: RloB; pfam13707 471855003504 FAD binding domain; Region: FAD_binding_2; pfam00890 471855003505 Predicted oxidoreductase [General function prediction only]; Region: COG3573 471855003506 Peptidase C26; Region: Peptidase_C26; pfam07722 471855003507 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471855003508 conserved cys residue [active] 471855003509 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 471855003510 PemK-like protein; Region: PemK; pfam02452 471855003511 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855003512 Predicted oxidoreductase [General function prediction only]; Region: COG3573 471855003513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855003514 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855003515 DNA binding residues [nucleotide binding] 471855003516 dimerization interface [polypeptide binding]; other site 471855003517 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471855003518 FAD binding domain; Region: FAD_binding_4; pfam01565 471855003519 aldose dehydrogenase; Validated; Region: PRK06398 471855003520 classical (c) SDRs; Region: SDR_c; cd05233 471855003521 NAD(P) binding site [chemical binding]; other site 471855003522 active site 471855003523 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471855003524 active site 471855003525 catalytic site [active] 471855003526 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471855003527 Chain length determinant protein; Region: Wzz; cl15801 471855003528 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471855003529 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855003530 PHP domain; Region: PHP; pfam02811 471855003531 Transposase IS200 like; Region: Y1_Tnp; pfam01797 471855003532 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855003533 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855003534 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855003535 Walker A/P-loop; other site 471855003536 ATP binding site [chemical binding]; other site 471855003537 Q-loop/lid; other site 471855003538 ABC transporter signature motif; other site 471855003539 Walker B; other site 471855003540 D-loop; other site 471855003541 H-loop/switch region; other site 471855003542 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855003543 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855003544 Walker A/P-loop; other site 471855003545 ATP binding site [chemical binding]; other site 471855003546 Q-loop/lid; other site 471855003547 ABC transporter signature motif; other site 471855003548 Walker B; other site 471855003549 D-loop; other site 471855003550 H-loop/switch region; other site 471855003551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855003552 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855003553 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855003554 Walker A/P-loop; other site 471855003555 ATP binding site [chemical binding]; other site 471855003556 Q-loop/lid; other site 471855003557 ABC transporter signature motif; other site 471855003558 Walker B; other site 471855003559 D-loop; other site 471855003560 H-loop/switch region; other site 471855003561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855003562 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855003563 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471855003564 Walker A/P-loop; other site 471855003565 ATP binding site [chemical binding]; other site 471855003566 Q-loop/lid; other site 471855003567 ABC transporter signature motif; other site 471855003568 Walker B; other site 471855003569 D-loop; other site 471855003570 H-loop/switch region; other site 471855003571 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471855003572 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471855003573 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471855003574 endonuclease III; Region: ENDO3c; smart00478 471855003575 minor groove reading motif; other site 471855003576 helix-hairpin-helix signature motif; other site 471855003577 substrate binding pocket [chemical binding]; other site 471855003578 active site 471855003579 Rubrerythrin [Energy production and conversion]; Region: COG1592 471855003580 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 471855003581 binuclear metal center [ion binding]; other site 471855003582 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 471855003583 iron binding site [ion binding]; other site 471855003584 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 471855003585 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 471855003586 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 471855003587 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 471855003588 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 471855003589 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855003590 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471855003591 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471855003592 homodimer interface [polypeptide binding]; other site 471855003593 substrate-cofactor binding pocket; other site 471855003594 catalytic residue [active] 471855003595 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471855003596 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 471855003597 PhoH-like protein; Region: PhoH; pfam02562 471855003598 GTPase Era; Reviewed; Region: era; PRK00089 471855003599 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471855003600 G1 box; other site 471855003601 GTP/Mg2+ binding site [chemical binding]; other site 471855003602 Switch I region; other site 471855003603 G2 box; other site 471855003604 Switch II region; other site 471855003605 G3 box; other site 471855003606 G4 box; other site 471855003607 G5 box; other site 471855003608 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855003609 DNA polymerase I; Provisional; Region: PRK05755 471855003610 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471855003611 active site 471855003612 metal binding site 1 [ion binding]; metal-binding site 471855003613 putative 5' ssDNA interaction site; other site 471855003614 metal binding site 3; metal-binding site 471855003615 metal binding site 2 [ion binding]; metal-binding site 471855003616 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471855003617 putative DNA binding site [nucleotide binding]; other site 471855003618 putative metal binding site [ion binding]; other site 471855003619 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 471855003620 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471855003621 active site 471855003622 DNA binding site [nucleotide binding] 471855003623 catalytic site [active] 471855003624 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471855003625 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471855003626 GTPase CgtA; Reviewed; Region: obgE; PRK12297 471855003627 GTP1/OBG; Region: GTP1_OBG; pfam01018 471855003628 Obg GTPase; Region: Obg; cd01898 471855003629 G1 box; other site 471855003630 GTP/Mg2+ binding site [chemical binding]; other site 471855003631 Switch I region; other site 471855003632 G2 box; other site 471855003633 G3 box; other site 471855003634 Switch II region; other site 471855003635 G4 box; other site 471855003636 G5 box; other site 471855003637 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 471855003638 gamma-glutamyl kinase; Provisional; Region: PRK05429 471855003639 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471855003640 nucleotide binding site [chemical binding]; other site 471855003641 homotetrameric interface [polypeptide binding]; other site 471855003642 putative phosphate binding site [ion binding]; other site 471855003643 putative allosteric binding site; other site 471855003644 PUA domain; Region: PUA; pfam01472 471855003645 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471855003646 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471855003647 active site 471855003648 (T/H)XGH motif; other site 471855003649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855003650 Zn2+ binding site [ion binding]; other site 471855003651 Mg2+ binding site [ion binding]; other site 471855003652 Oligomerisation domain; Region: Oligomerisation; pfam02410 471855003653 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471855003654 Predicted permeases [General function prediction only]; Region: COG0679 471855003655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855003656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855003657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855003658 dimerization interface [polypeptide binding]; other site 471855003659 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 471855003660 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 471855003661 active site 471855003662 nucleophile elbow; other site 471855003663 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 471855003664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855003665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855003666 dimer interface [polypeptide binding]; other site 471855003667 phosphorylation site [posttranslational modification] 471855003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855003669 ATP binding site [chemical binding]; other site 471855003670 Mg2+ binding site [ion binding]; other site 471855003671 G-X-G motif; other site 471855003672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855003673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855003674 active site 471855003675 phosphorylation site [posttranslational modification] 471855003676 intermolecular recognition site; other site 471855003677 dimerization interface [polypeptide binding]; other site 471855003678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855003679 DNA binding site [nucleotide binding] 471855003680 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 471855003681 putative metal binding residues [ion binding]; other site 471855003682 signature motif; other site 471855003683 dimer interface [polypeptide binding]; other site 471855003684 active site 471855003685 polyP binding site; other site 471855003686 substrate binding site [chemical binding]; other site 471855003687 acceptor-phosphate pocket; other site 471855003688 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471855003689 AzlC protein; Region: AzlC; pfam03591 471855003690 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 471855003691 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471855003692 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 471855003693 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471855003694 catalytic site [active] 471855003695 subunit interface [polypeptide binding]; other site 471855003696 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471855003697 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471855003698 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471855003699 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471855003700 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471855003701 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471855003702 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471855003703 IMP binding site; other site 471855003704 dimer interface [polypeptide binding]; other site 471855003705 partial ornithine binding site; other site 471855003706 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 471855003707 Flavoprotein; Region: Flavoprotein; pfam02441 471855003708 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471855003709 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471855003710 minor groove reading motif; other site 471855003711 helix-hairpin-helix signature motif; other site 471855003712 substrate binding pocket [chemical binding]; other site 471855003713 active site 471855003714 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 471855003715 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471855003716 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471855003717 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471855003718 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471855003719 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 471855003720 dimerization domain swap beta strand [polypeptide binding]; other site 471855003721 regulatory protein interface [polypeptide binding]; other site 471855003722 active site 471855003723 regulatory phosphorylation site [posttranslational modification]; other site 471855003724 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 471855003725 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 471855003726 active site 471855003727 phosphorylation site [posttranslational modification] 471855003728 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 471855003729 active site 471855003730 P-loop; other site 471855003731 phosphorylation site [posttranslational modification] 471855003732 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 471855003733 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471855003734 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471855003735 putative substrate binding site [chemical binding]; other site 471855003736 putative ATP binding site [chemical binding]; other site 471855003737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855003738 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855003739 DNA binding residues [nucleotide binding] 471855003740 dimerization interface [polypeptide binding]; other site 471855003741 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471855003742 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 471855003743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855003744 NAD(P) binding site [chemical binding]; other site 471855003745 active site 471855003746 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471855003747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855003748 S-adenosylmethionine binding site [chemical binding]; other site 471855003749 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 471855003750 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471855003751 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 471855003752 NADH dehydrogenase; Region: NADHdh; cl00469 471855003753 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 471855003754 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 471855003755 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 471855003756 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 471855003757 4Fe-4S binding domain; Region: Fer4; cl02805 471855003758 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855003759 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471855003760 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 471855003761 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855003762 acyl-activating enzyme (AAE) consensus motif; other site 471855003763 AMP binding site [chemical binding]; other site 471855003764 active site 471855003765 CoA binding site [chemical binding]; other site 471855003766 ACT domain-containing protein [General function prediction only]; Region: COG4747 471855003767 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 471855003768 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 471855003769 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 471855003770 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 471855003771 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 471855003772 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855003773 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471855003774 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471855003775 phosphopeptide binding site; other site 471855003776 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 471855003777 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471855003778 dimer interface [polypeptide binding]; other site 471855003779 PYR/PP interface [polypeptide binding]; other site 471855003780 TPP binding site [chemical binding]; other site 471855003781 substrate binding site [chemical binding]; other site 471855003782 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 471855003783 TPP-binding site; other site 471855003784 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 471855003785 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 471855003786 active site 471855003787 HIGH motif; other site 471855003788 nucleotide binding site [chemical binding]; other site 471855003789 active site 471855003790 KMSKS motif; other site 471855003791 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 471855003792 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471855003793 NAD binding site [chemical binding]; other site 471855003794 ligand binding site [chemical binding]; other site 471855003795 catalytic site [active] 471855003796 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 471855003797 UbiA prenyltransferase family; Region: UbiA; pfam01040 471855003798 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 471855003799 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 471855003800 putative tRNA-binding site [nucleotide binding]; other site 471855003801 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471855003802 active site 471855003803 DNA polymerase IV; Validated; Region: PRK02406 471855003804 DNA binding site [nucleotide binding] 471855003805 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 471855003806 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471855003807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855003808 ATP binding site [chemical binding]; other site 471855003809 putative Mg++ binding site [ion binding]; other site 471855003810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855003811 nucleotide binding region [chemical binding]; other site 471855003812 ATP-binding site [chemical binding]; other site 471855003813 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 471855003814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471855003815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855003816 active site 471855003817 ATP binding site [chemical binding]; other site 471855003818 substrate binding site [chemical binding]; other site 471855003819 activation loop (A-loop); other site 471855003820 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855003821 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471855003822 phosphopeptide binding site; other site 471855003823 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855003824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471855003825 active site 471855003826 ATP binding site [chemical binding]; other site 471855003827 substrate binding site [chemical binding]; other site 471855003828 activation loop (A-loop); other site 471855003829 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471855003830 active site 471855003831 ATP binding site [chemical binding]; other site 471855003832 Protein phosphatase 2C; Region: PP2C_2; pfam13672 471855003833 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855003834 metal ion-dependent adhesion site (MIDAS); other site 471855003835 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 471855003836 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855003837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855003838 Walker A/P-loop; other site 471855003839 ATP binding site [chemical binding]; other site 471855003840 Q-loop/lid; other site 471855003841 ABC transporter signature motif; other site 471855003842 Walker B; other site 471855003843 D-loop; other site 471855003844 H-loop/switch region; other site 471855003845 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 471855003846 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 471855003847 Walker A/P-loop; other site 471855003848 ATP binding site [chemical binding]; other site 471855003849 Q-loop/lid; other site 471855003850 ABC transporter signature motif; other site 471855003851 Walker B; other site 471855003852 D-loop; other site 471855003853 H-loop/switch region; other site 471855003854 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471855003855 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471855003856 Walker A/P-loop; other site 471855003857 ATP binding site [chemical binding]; other site 471855003858 Q-loop/lid; other site 471855003859 ABC transporter signature motif; other site 471855003860 Walker B; other site 471855003861 D-loop; other site 471855003862 H-loop/switch region; other site 471855003863 NMT1/THI5 like; Region: NMT1; pfam09084 471855003864 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471855003865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855003866 putative PBP binding loops; other site 471855003867 dimer interface [polypeptide binding]; other site 471855003868 ABC-ATPase subunit interface; other site 471855003869 Uncharacterized conserved protein [Function unknown]; Region: COG0011 471855003870 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 471855003871 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 471855003872 dimerization interface [polypeptide binding]; other site 471855003873 active site 471855003874 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 471855003875 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 471855003876 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471855003877 alanine dehydrogenase; Validated; Region: PRK06046 471855003878 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 471855003879 Predicted transcriptional regulators [Transcription]; Region: COG1695 471855003880 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471855003881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855003882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855003883 active site 471855003884 phosphorylation site [posttranslational modification] 471855003885 intermolecular recognition site; other site 471855003886 dimerization interface [polypeptide binding]; other site 471855003887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855003888 DNA binding site [nucleotide binding] 471855003889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855003890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471855003891 dimerization interface [polypeptide binding]; other site 471855003892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855003893 dimer interface [polypeptide binding]; other site 471855003894 phosphorylation site [posttranslational modification] 471855003895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855003896 ATP binding site [chemical binding]; other site 471855003897 Mg2+ binding site [ion binding]; other site 471855003898 G-X-G motif; other site 471855003899 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 471855003900 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 471855003901 transmembrane helices; other site 471855003902 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855003903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003904 FeS/SAM binding site; other site 471855003905 hypothetical protein; Validated; Region: PRK07121 471855003906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855003907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855003908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855003909 dimerization interface [polypeptide binding]; other site 471855003910 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471855003911 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 471855003912 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471855003913 E3 interaction surface; other site 471855003914 lipoyl attachment site [posttranslational modification]; other site 471855003915 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 471855003916 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855003917 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471855003918 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471855003919 OsmC-like protein; Region: OsmC; pfam02566 471855003920 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855003921 metal ion-dependent adhesion site (MIDAS); other site 471855003922 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 471855003923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855003924 Walker A motif; other site 471855003925 ATP binding site [chemical binding]; other site 471855003926 Walker B motif; other site 471855003927 arginine finger; other site 471855003928 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 471855003929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855003930 Fic family protein [Function unknown]; Region: COG3177 471855003931 Short C-terminal domain; Region: SHOCT; pfam09851 471855003932 RQC domain; Region: RQC; pfam09382 471855003933 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471855003934 Nuclease-related domain; Region: NERD; pfam08378 471855003935 Family description; Region: UvrD_C_2; pfam13538 471855003936 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855003937 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 471855003938 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 471855003939 Phage-related protein [Function unknown]; Region: COG4722 471855003940 Phage tail protein; Region: Sipho_tail; pfam05709 471855003941 Minor capsid protein; Region: Minor_capsid_1; pfam10665 471855003942 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855003943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003944 FeS/SAM binding site; other site 471855003945 Predicted helicase [General function prediction only]; Region: COG4889 471855003946 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 471855003947 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855003948 ATP binding site [chemical binding]; other site 471855003949 putative Mg++ binding site [ion binding]; other site 471855003950 nucleotide binding region [chemical binding]; other site 471855003951 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 471855003952 ATP-binding site [chemical binding]; other site 471855003953 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855003954 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855003955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855003956 non-specific DNA binding site [nucleotide binding]; other site 471855003957 salt bridge; other site 471855003958 sequence-specific DNA binding site [nucleotide binding]; other site 471855003959 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855003960 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 471855003961 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471855003962 Int/Topo IB signature motif; other site 471855003963 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 471855003964 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 471855003965 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 471855003966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855003967 FeS/SAM binding site; other site 471855003968 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 471855003969 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 471855003970 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 471855003971 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471855003972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471855003973 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 471855003974 rod shape-determining protein MreC; Provisional; Region: PRK13922 471855003975 rod shape-determining protein MreC; Region: MreC; pfam04085 471855003976 rod shape-determining protein MreB; Provisional; Region: PRK13927 471855003977 MreB and similar proteins; Region: MreB_like; cd10225 471855003978 nucleotide binding site [chemical binding]; other site 471855003979 Mg binding site [ion binding]; other site 471855003980 putative protofilament interaction site [polypeptide binding]; other site 471855003981 RodZ interaction site [polypeptide binding]; other site 471855003982 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471855003983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855003984 S-adenosylmethionine binding site [chemical binding]; other site 471855003985 peptide chain release factor 1; Validated; Region: prfA; PRK00591 471855003986 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471855003987 RF-1 domain; Region: RF-1; pfam00472 471855003988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 471855003989 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471855003990 substrate binding pocket [chemical binding]; other site 471855003991 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471855003992 catalytic residues [active] 471855003993 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 471855003994 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 471855003995 active site 471855003996 nucleophile elbow; other site 471855003997 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471855003998 OpgC protein; Region: OpgC_C; cl17858 471855003999 Eukaryotic protein of unknown function (DUF914); Region: DUF914; pfam06027 471855004000 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471855004001 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471855004002 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 471855004003 Ligand binding site; other site 471855004004 Putative Catalytic site; other site 471855004005 DXD motif; other site 471855004006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855004007 Coenzyme A binding pocket [chemical binding]; other site 471855004008 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471855004009 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471855004010 inhibitor-cofactor binding pocket; inhibition site 471855004011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855004012 catalytic residue [active] 471855004013 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471855004014 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471855004015 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471855004016 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 471855004017 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471855004018 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471855004019 NAD binding site [chemical binding]; other site 471855004020 substrate binding site [chemical binding]; other site 471855004021 homodimer interface [polypeptide binding]; other site 471855004022 active site 471855004023 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471855004024 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471855004025 substrate binding site; other site 471855004026 tetramer interface; other site 471855004027 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 471855004028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471855004029 active site 471855004030 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 471855004031 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471855004032 active site 471855004033 catalytic residues [active] 471855004034 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004035 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004036 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004037 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004038 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004039 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 471855004040 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004041 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004042 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004043 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004044 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004045 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004046 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004047 Uncharacterized distant relative of cell wall-associated hydrolases [Function unknown]; Region: COG3863 471855004048 LicD family; Region: LicD; pfam04991 471855004049 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471855004050 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471855004051 Homeodomain-like domain; Region: HTH_23; pfam13384 471855004052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471855004053 Helix-turn-helix domain; Region: HTH_28; pfam13518 471855004054 putative transposase OrfB; Reviewed; Region: PHA02517 471855004055 HTH-like domain; Region: HTH_21; pfam13276 471855004056 Integrase core domain; Region: rve; pfam00665 471855004057 Integrase core domain; Region: rve_2; pfam13333 471855004058 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004059 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855004060 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855004061 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855004062 NlpC/P60 family; Region: NLPC_P60; cl17555 471855004063 LicD family; Region: LicD; pfam04991 471855004064 LicD family; Region: LicD; pfam04991 471855004065 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 471855004066 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471855004067 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 471855004068 putative NAD(P) binding site [chemical binding]; other site 471855004069 catalytic Zn binding site [ion binding]; other site 471855004070 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471855004071 substrate binding site; other site 471855004072 dimer interface; other site 471855004073 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471855004074 active site 471855004075 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471855004076 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471855004077 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 471855004078 DHHW protein; Region: DHHW; pfam14286 471855004079 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471855004080 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471855004081 substrate binding site; other site 471855004082 dimer interface; other site 471855004083 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 471855004084 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471855004085 putative NAD(P) binding site [chemical binding]; other site 471855004086 putative catalytic Zn binding site [ion binding]; other site 471855004087 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471855004088 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471855004089 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471855004090 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471855004091 active site 471855004092 nucleotide binding site [chemical binding]; other site 471855004093 HIGH motif; other site 471855004094 KMSKS motif; other site 471855004095 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471855004096 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471855004097 Mg++ binding site [ion binding]; other site 471855004098 putative catalytic motif [active] 471855004099 substrate binding site [chemical binding]; other site 471855004100 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471855004101 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 471855004102 Walker A/P-loop; other site 471855004103 ATP binding site [chemical binding]; other site 471855004104 Q-loop/lid; other site 471855004105 ABC transporter signature motif; other site 471855004106 Walker B; other site 471855004107 D-loop; other site 471855004108 H-loop/switch region; other site 471855004109 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 471855004110 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471855004111 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471855004112 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471855004113 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471855004114 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471855004115 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 471855004116 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471855004117 non-specific DNA interactions [nucleotide binding]; other site 471855004118 DNA binding site [nucleotide binding] 471855004119 sequence specific DNA binding site [nucleotide binding]; other site 471855004120 putative cAMP binding site [chemical binding]; other site 471855004121 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 471855004122 active site 471855004123 metal-binding site 471855004124 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471855004125 active site 471855004126 substrate binding site [chemical binding]; other site 471855004127 ATP binding site [chemical binding]; other site 471855004128 Phosphotransferase enzyme family; Region: APH; pfam01636 471855004129 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 471855004130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471855004131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471855004132 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471855004133 Ligand Binding Site [chemical binding]; other site 471855004134 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471855004135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855004136 UDP-galactopyranose mutase; Region: GLF; pfam03275 471855004137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855004138 putative substrate translocation pore; other site 471855004139 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 471855004140 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 471855004141 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471855004142 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471855004143 Walker A/P-loop; other site 471855004144 ATP binding site [chemical binding]; other site 471855004145 Q-loop/lid; other site 471855004146 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 471855004147 ABC transporter signature motif; other site 471855004148 Walker B; other site 471855004149 D-loop; other site 471855004150 H-loop/switch region; other site 471855004151 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 471855004152 putative active site [active] 471855004153 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 471855004154 pyrophosphatase PpaX; Provisional; Region: PRK13288 471855004155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855004156 motif II; other site 471855004157 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471855004158 putative active site [active] 471855004159 dimerization interface [polypeptide binding]; other site 471855004160 putative tRNAtyr binding site [nucleotide binding]; other site 471855004161 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 471855004162 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 471855004163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471855004164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855004165 ATP binding site [chemical binding]; other site 471855004166 putative Mg++ binding site [ion binding]; other site 471855004167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855004168 nucleotide binding region [chemical binding]; other site 471855004169 ATP-binding site [chemical binding]; other site 471855004170 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471855004171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855004172 ATP binding site [chemical binding]; other site 471855004173 putative Mg++ binding site [ion binding]; other site 471855004174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855004175 nucleotide binding region [chemical binding]; other site 471855004176 ATP-binding site [chemical binding]; other site 471855004177 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471855004178 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471855004179 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471855004180 active site 471855004181 HIGH motif; other site 471855004182 dimer interface [polypeptide binding]; other site 471855004183 KMSKS motif; other site 471855004184 NTPase; Region: NTPase_1; cl17478 471855004185 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 471855004186 B3/4 domain; Region: B3_4; pfam03483 471855004187 Uncharacterized conserved protein [Function unknown]; Region: COG1739 471855004188 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 471855004189 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 471855004190 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 471855004191 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004192 FeS/SAM binding site; other site 471855004193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855004194 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471855004195 Walker A motif; other site 471855004196 ATP binding site [chemical binding]; other site 471855004197 Walker B motif; other site 471855004198 arginine finger; other site 471855004199 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471855004200 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 471855004201 active site 471855004202 Protein kinase domain; Region: Pkinase; pfam00069 471855004203 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855004204 active site 471855004205 ATP binding site [chemical binding]; other site 471855004206 substrate binding site [chemical binding]; other site 471855004207 activation loop (A-loop); other site 471855004208 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471855004209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855004210 ABC transporter; Region: ABC_tran_2; pfam12848 471855004211 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855004212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855004213 catalytic core [active] 471855004214 CHAD domain; Region: CHAD; pfam05235 471855004215 Homoserine O-succinyltransferase; Region: HTS; pfam04204 471855004216 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 471855004217 proposed active site lysine [active] 471855004218 conserved cys residue [active] 471855004219 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 471855004220 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471855004221 homodimer interface [polypeptide binding]; other site 471855004222 substrate-cofactor binding pocket; other site 471855004223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855004224 catalytic residue [active] 471855004225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471855004226 Helix-turn-helix domain; Region: HTH_28; pfam13518 471855004227 putative transposase OrfB; Reviewed; Region: PHA02517 471855004228 HTH-like domain; Region: HTH_21; pfam13276 471855004229 Integrase core domain; Region: rve; pfam00665 471855004230 Integrase core domain; Region: rve_2; pfam13333 471855004231 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471855004232 active site 471855004233 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 471855004234 FAD binding domain; Region: FAD_binding_4; pfam01565 471855004235 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471855004236 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 471855004237 ArsC family; Region: ArsC; pfam03960 471855004238 putative ArsC-like catalytic residues; other site 471855004239 putative TRX-like catalytic residues [active] 471855004240 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 471855004241 flavoprotein, HI0933 family; Region: TIGR00275 471855004242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855004243 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 471855004244 NifU-like domain; Region: NifU; cl00484 471855004245 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 471855004246 Desulfoferrodoxin; Region: Desulfoferrodox; pfam01880 471855004247 non-heme iron binding site [ion binding]; other site 471855004248 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471855004249 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471855004250 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471855004251 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471855004252 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 471855004253 hinge; other site 471855004254 active site 471855004255 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471855004256 23S rRNA binding site [nucleotide binding]; other site 471855004257 L21 binding site [polypeptide binding]; other site 471855004258 L13 binding site [polypeptide binding]; other site 471855004259 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471855004260 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 471855004261 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471855004262 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471855004263 histidinol-phosphatase; Provisional; Region: PRK07328 471855004264 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 471855004265 active site 471855004266 dimer interface [polypeptide binding]; other site 471855004267 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 471855004268 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471855004269 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471855004270 substrate binding site [chemical binding]; other site 471855004271 glutamase interaction surface [polypeptide binding]; other site 471855004272 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471855004273 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 471855004274 catalytic residues [active] 471855004275 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 471855004276 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471855004277 putative active site [active] 471855004278 oxyanion strand; other site 471855004279 catalytic triad [active] 471855004280 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471855004281 putative active site pocket [active] 471855004282 4-fold oligomerization interface [polypeptide binding]; other site 471855004283 metal binding residues [ion binding]; metal-binding site 471855004284 3-fold/trimer interface [polypeptide binding]; other site 471855004285 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 471855004286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855004288 homodimer interface [polypeptide binding]; other site 471855004289 catalytic residue [active] 471855004290 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471855004291 histidinol dehydrogenase; Region: hisD; TIGR00069 471855004292 NAD binding site [chemical binding]; other site 471855004293 dimerization interface [polypeptide binding]; other site 471855004294 product binding site; other site 471855004295 substrate binding site [chemical binding]; other site 471855004296 zinc binding site [ion binding]; other site 471855004297 catalytic residues [active] 471855004298 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 471855004299 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471855004300 dimer interface [polypeptide binding]; other site 471855004301 motif 1; other site 471855004302 active site 471855004303 motif 2; other site 471855004304 motif 3; other site 471855004305 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 471855004306 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 471855004307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471855004308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471855004309 substrate binding pocket [chemical binding]; other site 471855004310 membrane-bound complex binding site; other site 471855004311 hinge residues; other site 471855004312 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471855004313 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855004314 active site 471855004315 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 471855004316 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 471855004317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004318 FeS/SAM binding site; other site 471855004319 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471855004320 amidase catalytic site [active] 471855004321 Zn binding residues [ion binding]; other site 471855004322 substrate binding site [chemical binding]; other site 471855004323 Transglutaminase family, C-terminal ig like domain; Region: Transglut_C; pfam00927 471855004324 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 471855004325 baseplate wedge subunit and tail pin; Provisional; Region: 10; PHA02582 471855004326 Phage-related protein [Function unknown]; Region: COG5412 471855004327 Phage capsid family; Region: Phage_capsid; pfam05065 471855004328 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 471855004329 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 471855004330 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 471855004331 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 471855004332 HNH endonuclease; Region: HNH_3; pfam13392 471855004333 MarR family; Region: MarR_2; pfam12802 471855004334 Trm112p-like protein; Region: Trm112p; pfam03966 471855004335 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855004336 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855004337 active site 471855004338 DNA binding site [nucleotide binding] 471855004339 Int/Topo IB signature motif; other site 471855004340 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855004341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855004342 non-specific DNA binding site [nucleotide binding]; other site 471855004343 salt bridge; other site 471855004344 sequence-specific DNA binding site [nucleotide binding]; other site 471855004345 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855004346 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855004347 non-specific DNA binding site [nucleotide binding]; other site 471855004348 salt bridge; other site 471855004349 sequence-specific DNA binding site [nucleotide binding]; other site 471855004350 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855004351 active site 471855004352 Int/Topo IB signature motif; other site 471855004353 DNA binding site [nucleotide binding] 471855004354 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855004355 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471855004356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471855004357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855004358 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855004359 putative substrate translocation pore; other site 471855004360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855004361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855004362 non-specific DNA binding site [nucleotide binding]; other site 471855004363 salt bridge; other site 471855004364 sequence-specific DNA binding site [nucleotide binding]; other site 471855004365 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855004366 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855004367 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 471855004368 Peptidase family M28; Region: Peptidase_M28; pfam04389 471855004369 metal binding site [ion binding]; metal-binding site 471855004370 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 471855004371 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 471855004372 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 471855004373 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471855004374 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471855004375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855004376 active site 471855004377 motif I; other site 471855004378 motif II; other site 471855004379 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 471855004380 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471855004381 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471855004382 aspartate kinase; Reviewed; Region: PRK09034 471855004383 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 471855004384 nucleotide binding site [chemical binding]; other site 471855004385 substrate binding site [chemical binding]; other site 471855004386 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471855004387 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 471855004388 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 471855004389 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 471855004390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855004391 catalytic residue [active] 471855004392 homoserine kinase; Provisional; Region: PRK01212 471855004393 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 471855004394 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471855004395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471855004396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855004397 Walker A motif; other site 471855004398 ATP binding site [chemical binding]; other site 471855004399 Walker B motif; other site 471855004400 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 471855004401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864 471855004402 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471855004403 metal ion-dependent adhesion site (MIDAS); other site 471855004404 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855004405 FeoA domain; Region: FeoA; pfam04023 471855004406 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471855004407 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471855004408 G1 box; other site 471855004409 GTP/Mg2+ binding site [chemical binding]; other site 471855004410 Switch I region; other site 471855004411 G2 box; other site 471855004412 G3 box; other site 471855004413 Switch II region; other site 471855004414 G4 box; other site 471855004415 G5 box; other site 471855004416 Nucleoside recognition; Region: Gate; pfam07670 471855004417 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471855004418 Nucleoside recognition; Region: Gate; pfam07670 471855004419 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855004420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004421 FeS/SAM binding site; other site 471855004422 EDD domain protein, DegV family; Region: DegV; TIGR00762 471855004423 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471855004424 EDD domain protein, DegV family; Region: DegV; TIGR00762 471855004425 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471855004426 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471855004427 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471855004428 active site 471855004429 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 471855004430 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 471855004431 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471855004432 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 471855004433 thymidylate kinase; Validated; Region: tmk; PRK00698 471855004434 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471855004435 TMP-binding site; other site 471855004436 ATP-binding site [chemical binding]; other site 471855004437 Fumarase C-terminus; Region: Fumerase_C; cl00795 471855004438 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 471855004439 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471855004440 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471855004441 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471855004442 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471855004443 elongation factor G; Reviewed; Region: PRK00007 471855004444 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471855004445 G1 box; other site 471855004446 putative GEF interaction site [polypeptide binding]; other site 471855004447 GTP/Mg2+ binding site [chemical binding]; other site 471855004448 Switch I region; other site 471855004449 G2 box; other site 471855004450 G3 box; other site 471855004451 Switch II region; other site 471855004452 G4 box; other site 471855004453 G5 box; other site 471855004454 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471855004455 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471855004456 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471855004457 30S ribosomal protein S7; Validated; Region: PRK05302 471855004458 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471855004459 S17 interaction site [polypeptide binding]; other site 471855004460 S8 interaction site; other site 471855004461 16S rRNA interaction site [nucleotide binding]; other site 471855004462 streptomycin interaction site [chemical binding]; other site 471855004463 23S rRNA interaction site [nucleotide binding]; other site 471855004464 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471855004465 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471855004466 Ligand Binding Site [chemical binding]; other site 471855004467 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 471855004468 pyrroline-5-carboxylate reductase; Region: PLN02688 471855004469 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 471855004470 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471855004471 DHHA2 domain; Region: DHHA2; pfam02833 471855004472 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 471855004473 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471855004474 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 471855004475 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 471855004476 CAAX protease self-immunity; Region: Abi; pfam02517 471855004477 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471855004478 Part of AAA domain; Region: AAA_19; pfam13245 471855004479 Family description; Region: UvrD_C_2; pfam13538 471855004480 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 471855004481 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471855004482 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471855004483 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471855004484 active site 471855004485 dimer interface [polypeptide binding]; other site 471855004486 motif 1; other site 471855004487 motif 2; other site 471855004488 motif 3; other site 471855004489 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471855004490 anticodon binding site; other site 471855004491 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 471855004492 Predicted ATPase [General function prediction only]; Region: COG3911 471855004493 AAA domain; Region: AAA_28; pfam13521 471855004494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855004495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855004496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855004497 Walker A/P-loop; other site 471855004498 ATP binding site [chemical binding]; other site 471855004499 Q-loop/lid; other site 471855004500 ABC transporter signature motif; other site 471855004501 Walker B; other site 471855004502 D-loop; other site 471855004503 H-loop/switch region; other site 471855004504 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855004505 Double zinc ribbon; Region: DZR; pfam12773 471855004506 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 471855004507 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 471855004508 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 471855004509 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 471855004510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855004511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855004512 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 471855004513 Walker A/P-loop; other site 471855004514 ATP binding site [chemical binding]; other site 471855004515 Q-loop/lid; other site 471855004516 ABC transporter signature motif; other site 471855004517 Walker B; other site 471855004518 D-loop; other site 471855004519 H-loop/switch region; other site 471855004520 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471855004521 Na2 binding site [ion binding]; other site 471855004522 putative substrate binding site 1 [chemical binding]; other site 471855004523 Na binding site 1 [ion binding]; other site 471855004524 putative substrate binding site 2 [chemical binding]; other site 471855004525 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 471855004526 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 471855004527 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 471855004528 G1 box; other site 471855004529 GTP/Mg2+ binding site [chemical binding]; other site 471855004530 Switch I region; other site 471855004531 G2 box; other site 471855004532 Switch II region; other site 471855004533 G3 box; other site 471855004534 G4 box; other site 471855004535 G5 box; other site 471855004536 [FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955 471855004537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004538 FeS/SAM binding site; other site 471855004539 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 471855004540 [FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956 471855004541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004542 FeS/SAM binding site; other site 471855004543 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 471855004544 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 471855004545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471855004546 catalytic loop [active] 471855004547 iron binding site [ion binding]; other site 471855004548 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 471855004549 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 471855004550 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 471855004551 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 471855004552 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 471855004553 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 471855004554 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855004555 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 471855004556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855004557 non-specific DNA binding site [nucleotide binding]; other site 471855004558 salt bridge; other site 471855004559 sequence-specific DNA binding site [nucleotide binding]; other site 471855004560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855004561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855004562 homodimer interface [polypeptide binding]; other site 471855004563 catalytic residue [active] 471855004564 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 471855004565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855004566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471855004567 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471855004568 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 471855004569 active site residue [active] 471855004570 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471855004571 active site residue [active] 471855004572 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 471855004573 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471855004574 active site 471855004575 catalytic tetrad [active] 471855004576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855004577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471855004578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855004579 Coenzyme A binding pocket [chemical binding]; other site 471855004580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855004581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855004582 DNA binding residues [nucleotide binding] 471855004583 dimerization interface [polypeptide binding]; other site 471855004584 hypothetical protein; Validated; Region: PRK07121 471855004585 Predicted oxidoreductase [General function prediction only]; Region: COG3573 471855004586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855004587 dimerization interface [polypeptide binding]; other site 471855004588 putative DNA binding site [nucleotide binding]; other site 471855004589 putative Zn2+ binding site [ion binding]; other site 471855004590 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 471855004591 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471855004592 homotrimer interaction site [polypeptide binding]; other site 471855004593 putative active site [active] 471855004594 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471855004595 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471855004596 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471855004597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855004598 RNA binding surface [nucleotide binding]; other site 471855004599 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 471855004600 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 471855004601 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471855004602 LytTr DNA-binding domain; Region: LytTR; pfam04397 471855004603 GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519 471855004604 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471855004605 ATP Binding subdomain [chemical binding]; other site 471855004606 Ligand Binding sites [chemical binding]; other site 471855004607 Dimerization subdomain; other site 471855004608 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855004609 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004610 FeS/SAM binding site; other site 471855004611 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471855004612 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 471855004613 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471855004614 DNA binding residues [nucleotide binding] 471855004615 drug binding residues [chemical binding]; other site 471855004616 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855004617 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855004618 metal coordination site [ion binding]; other site 471855004619 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 471855004620 heme-binding residues [chemical binding]; other site 471855004621 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855004622 Moco binding site; other site 471855004623 metal coordination site [ion binding]; other site 471855004624 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 471855004625 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 471855004626 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855004627 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855004628 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 471855004629 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471855004630 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 471855004631 4Fe-4S binding domain; Region: Fer4_5; pfam12801 471855004632 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 471855004633 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855004634 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855004635 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855004636 molybdopterin cofactor binding site; other site 471855004637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855004638 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855004639 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855004640 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 471855004641 putative molybdopterin cofactor binding site; other site 471855004642 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855004643 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855004644 4Fe-4S binding domain; Region: Fer4; pfam00037 471855004645 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855004646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855004647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855004648 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855004649 Ferredoxin [Energy production and conversion]; Region: COG1146 471855004650 4Fe-4S binding domain; Region: Fer4; pfam00037 471855004651 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 471855004652 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855004653 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855004654 Uncharacterized conserved protein [Function unknown]; Region: COG1359 471855004655 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 471855004656 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855004657 metal ion-dependent adhesion site (MIDAS); other site 471855004658 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855004659 Double zinc ribbon; Region: DZR; pfam12773 471855004660 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 471855004661 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004662 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 471855004663 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 471855004664 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 471855004665 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471855004666 4-alpha-glucanotransferase; Provisional; Region: PRK14508 471855004667 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 471855004668 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471855004669 active site 471855004670 homodimer interface [polypeptide binding]; other site 471855004671 catalytic site [active] 471855004672 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 471855004673 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 471855004674 active site pocket [active] 471855004675 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 471855004676 glycogen synthase; Provisional; Region: glgA; PRK00654 471855004677 ADP-binding pocket [chemical binding]; other site 471855004678 homodimer interface [polypeptide binding]; other site 471855004679 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 471855004680 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471855004681 active site 471855004682 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471855004683 dimer interface [polypeptide binding]; other site 471855004684 N-terminal domain interface [polypeptide binding]; other site 471855004685 sulfate 1 binding site; other site 471855004686 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 471855004687 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471855004688 ligand binding site; other site 471855004689 oligomer interface; other site 471855004690 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471855004691 dimer interface [polypeptide binding]; other site 471855004692 N-terminal domain interface [polypeptide binding]; other site 471855004693 sulfate 1 binding site; other site 471855004694 glycogen branching enzyme; Provisional; Region: PRK12313 471855004695 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471855004696 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471855004697 active site 471855004698 catalytic site [active] 471855004699 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471855004700 TIGR04076 family protein; Region: TIGR04076 471855004701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855004702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855004703 DNA binding residues [nucleotide binding] 471855004704 dimerization interface [polypeptide binding]; other site 471855004705 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855004706 4Fe-4S binding domain; Region: Fer4; pfam00037 471855004707 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 471855004708 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 471855004709 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 471855004710 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471855004711 AMP-binding domain protein; Validated; Region: PRK08315 471855004712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855004713 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 471855004714 acyl-activating enzyme (AAE) consensus motif; other site 471855004715 putative AMP binding site [chemical binding]; other site 471855004716 putative active site [active] 471855004717 putative CoA binding site [chemical binding]; other site 471855004718 2-isopropylmalate synthase; Validated; Region: PRK00915 471855004719 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 471855004720 active site 471855004721 catalytic residues [active] 471855004722 metal binding site [ion binding]; metal-binding site 471855004723 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471855004724 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 471855004725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471855004726 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471855004727 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471855004728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471855004729 catalytic residue [active] 471855004730 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 471855004731 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471855004732 acyl-activating enzyme (AAE) consensus motif; other site 471855004733 AMP binding site [chemical binding]; other site 471855004734 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 471855004735 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 471855004736 Domain of unknown function (DUF697); Region: DUF697; cl12064 471855004737 Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098 471855004738 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 471855004739 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 471855004740 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 471855004741 Predicted membrane protein [Function unknown]; Region: COG3326 471855004742 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471855004743 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471855004744 active site 471855004745 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 471855004746 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 471855004747 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471855004748 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471855004749 nudix motif; other site 471855004750 nudix motif; other site 471855004751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855004752 S-adenosylmethionine binding site [chemical binding]; other site 471855004753 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 471855004754 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855004755 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471855004756 acyl-activating enzyme (AAE) consensus motif; other site 471855004757 AMP binding site [chemical binding]; other site 471855004758 active site 471855004759 CoA binding site [chemical binding]; other site 471855004760 Cupin domain; Region: Cupin_2; pfam07883 471855004761 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471855004762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855004763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855004764 DNA binding residues [nucleotide binding] 471855004765 von Willebrand factor; Region: vWF_A; pfam12450 471855004766 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 471855004767 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 471855004768 metal ion-dependent adhesion site (MIDAS); other site 471855004769 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 471855004770 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 471855004771 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004772 FeS/SAM binding site; other site 471855004773 hypothetical protein; Provisional; Region: PRK03881 471855004774 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 471855004775 AMMECR1; Region: AMMECR1; pfam01871 471855004776 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471855004777 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471855004778 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 471855004779 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 471855004780 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471855004781 Na2 binding site [ion binding]; other site 471855004782 putative substrate binding site 1 [chemical binding]; other site 471855004783 Na binding site 1 [ion binding]; other site 471855004784 putative substrate binding site 2 [chemical binding]; other site 471855004785 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471855004786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855004787 Walker A motif; other site 471855004788 ATP binding site [chemical binding]; other site 471855004789 Walker B motif; other site 471855004790 arginine finger; other site 471855004791 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 471855004792 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 471855004793 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 471855004794 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855004795 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 471855004796 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 471855004797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471855004798 substrate binding site [chemical binding]; other site 471855004799 ATP binding site [chemical binding]; other site 471855004800 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 471855004801 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 471855004802 active site 471855004803 putative substrate binding pocket [chemical binding]; other site 471855004804 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 471855004805 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 471855004806 homotetramer interface [polypeptide binding]; other site 471855004807 ligand binding site [chemical binding]; other site 471855004808 catalytic site [active] 471855004809 NAD binding site [chemical binding]; other site 471855004810 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 471855004811 Predicted transcriptional regulators [Transcription]; Region: COG1695 471855004812 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471855004813 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 471855004814 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855004815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855004816 non-specific DNA binding site [nucleotide binding]; other site 471855004817 salt bridge; other site 471855004818 sequence-specific DNA binding site [nucleotide binding]; other site 471855004819 Cupin domain; Region: Cupin_2; pfam07883 471855004820 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855004821 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 471855004822 acyl-activating enzyme (AAE) consensus motif; other site 471855004823 AMP binding site [chemical binding]; other site 471855004824 active site 471855004825 CoA binding site [chemical binding]; other site 471855004826 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855004827 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855004828 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 471855004829 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 471855004830 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471855004831 dimer interface [polypeptide binding]; other site 471855004832 PYR/PP interface [polypeptide binding]; other site 471855004833 TPP binding site [chemical binding]; other site 471855004834 substrate binding site [chemical binding]; other site 471855004835 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 471855004836 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 471855004837 TPP-binding site [chemical binding]; other site 471855004838 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 471855004839 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471855004840 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855004841 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855004842 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471855004843 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471855004844 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855004845 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471855004846 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471855004847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855004848 ATP binding site [chemical binding]; other site 471855004849 putative Mg++ binding site [ion binding]; other site 471855004850 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471855004851 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471855004852 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471855004853 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471855004854 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471855004855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855004856 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471855004857 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471855004858 G1 box; other site 471855004859 GTP/Mg2+ binding site [chemical binding]; other site 471855004860 Switch I region; other site 471855004861 G2 box; other site 471855004862 G3 box; other site 471855004863 Switch II region; other site 471855004864 G4 box; other site 471855004865 G5 box; other site 471855004866 Nucleoside recognition; Region: Gate; pfam07670 471855004867 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471855004868 Nucleoside recognition; Region: Gate; pfam07670 471855004869 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 471855004870 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471855004871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471855004872 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 471855004873 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 471855004874 Cysteine-rich domain; Region: CCG; pfam02754 471855004875 Cysteine-rich domain; Region: CCG; pfam02754 471855004876 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 471855004877 hypothetical protein; Provisional; Region: PRK07236 471855004878 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 471855004879 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855004880 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 471855004881 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 471855004882 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 471855004883 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 471855004884 FAD binding pocket [chemical binding]; other site 471855004885 FAD binding motif [chemical binding]; other site 471855004886 phosphate binding motif [ion binding]; other site 471855004887 beta-alpha-beta structure motif; other site 471855004888 NAD binding pocket [chemical binding]; other site 471855004889 Iron coordination center [ion binding]; other site 471855004890 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 471855004891 L-lactate permease; Region: Lactate_perm; cl00701 471855004892 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471855004893 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471855004894 DNA binding site [nucleotide binding] 471855004895 active site 471855004896 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 471855004897 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471855004898 Coenzyme A binding pocket [chemical binding]; other site 471855004899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855004900 active site 471855004901 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471855004902 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 471855004903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471855004904 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471855004905 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471855004906 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 471855004907 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855004908 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855004909 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855004910 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855004911 molybdopterin cofactor binding site; other site 471855004912 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855004913 molybdopterin cofactor binding site; other site 471855004914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855004915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855004916 DNA binding residues [nucleotide binding] 471855004917 dimerization interface [polypeptide binding]; other site 471855004918 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471855004919 EamA-like transporter family; Region: EamA; pfam00892 471855004920 EamA-like transporter family; Region: EamA; pfam00892 471855004921 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 471855004922 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 471855004923 radical SAM enzyme, rSAM/lipoprotein system; Region: rSAM_w_lipo; TIGR04133 471855004924 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004925 FeS/SAM binding site; other site 471855004926 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471855004927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855004928 MarR family; Region: MarR_2; pfam12802 471855004929 EDD domain protein, DegV family; Region: DegV; TIGR00762 471855004930 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471855004931 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471855004932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855004933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855004934 active site 471855004935 phosphorylation site [posttranslational modification] 471855004936 intermolecular recognition site; other site 471855004937 dimerization interface [polypeptide binding]; other site 471855004938 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855004939 DNA binding site [nucleotide binding] 471855004940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855004941 dimer interface [polypeptide binding]; other site 471855004942 phosphorylation site [posttranslational modification] 471855004943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855004944 ATP binding site [chemical binding]; other site 471855004945 Mg2+ binding site [ion binding]; other site 471855004946 G-X-G motif; other site 471855004947 Predicted membrane protein [Function unknown]; Region: COG2860 471855004948 UPF0126 domain; Region: UPF0126; pfam03458 471855004949 UPF0126 domain; Region: UPF0126; pfam03458 471855004950 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471855004951 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 471855004952 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855004953 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855004954 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855004955 dimerization interface [polypeptide binding]; other site 471855004956 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 471855004957 Cyclophilin-like; Region: Cyclophil_like; cl17583 471855004958 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855004959 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855004960 Uncharacterized conserved protein [Function unknown]; Region: COG4925 471855004961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471855004962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471855004963 active site 471855004964 catalytic tetrad [active] 471855004965 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471855004966 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471855004967 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471855004968 DNA binding residues [nucleotide binding] 471855004969 putative dimer interface [polypeptide binding]; other site 471855004970 flavodoxin; Provisional; Region: PRK07116 471855004971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471855004972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471855004973 active site 471855004974 catalytic tetrad [active] 471855004975 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 471855004976 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471855004977 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471855004978 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471855004979 intersubunit interface [polypeptide binding]; other site 471855004980 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471855004981 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471855004982 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471855004983 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471855004984 ABC-ATPase subunit interface; other site 471855004985 dimer interface [polypeptide binding]; other site 471855004986 putative PBP binding regions; other site 471855004987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471855004988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855004989 binding surface 471855004990 TPR motif; other site 471855004991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471855004992 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 471855004993 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 471855004994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855004995 FeS/SAM binding site; other site 471855004996 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 471855004997 ATP cone domain; Region: ATP-cone; pfam03477 471855004998 Class III ribonucleotide reductase; Region: RNR_III; cd01675 471855004999 effector binding site; other site 471855005000 active site 471855005001 Zn binding site [ion binding]; other site 471855005002 glycine loop; other site 471855005003 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471855005004 catalytic residues [active] 471855005005 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471855005006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855005007 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 471855005008 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 471855005009 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471855005010 FMN binding site [chemical binding]; other site 471855005011 dimer interface [polypeptide binding]; other site 471855005012 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471855005013 Predicted transcriptional regulators [Transcription]; Region: COG1733 471855005014 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471855005015 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855005016 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855005017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471855005018 dimerization interface [polypeptide binding]; other site 471855005019 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 471855005020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855005021 FeS/SAM binding site; other site 471855005022 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 471855005023 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 471855005024 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471855005025 putative NAD(P) binding site [chemical binding]; other site 471855005026 4Fe-4S binding domain; Region: Fer4; pfam00037 471855005027 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 471855005028 Nitroreductase family; Region: Nitroreductase; pfam00881 471855005029 FMN binding site [chemical binding]; other site 471855005030 dimer interface [polypeptide binding]; other site 471855005031 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471855005032 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471855005033 putative NAD(P) binding site [chemical binding]; other site 471855005034 Predicted transcriptional regulator [Transcription]; Region: COG1959 471855005035 Transcriptional regulator; Region: Rrf2; pfam02082 471855005036 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855005037 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855005038 salt bridge; other site 471855005039 non-specific DNA binding site [nucleotide binding]; other site 471855005040 sequence-specific DNA binding site [nucleotide binding]; other site 471855005041 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 471855005042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855005043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005044 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471855005045 short chain dehydrogenase; Provisional; Region: PRK06940 471855005046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855005047 NAD(P) binding site [chemical binding]; other site 471855005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855005049 NAD(P) binding site [chemical binding]; other site 471855005050 active site 471855005051 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 471855005052 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471855005053 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471855005054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471855005055 DNA-binding site [nucleotide binding]; DNA binding site 471855005056 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855005057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855005058 homodimer interface [polypeptide binding]; other site 471855005059 catalytic residue [active] 471855005060 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855005061 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005062 molybdopterin cofactor binding site; other site 471855005063 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855005064 molybdopterin cofactor binding site; other site 471855005065 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855005066 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855005067 ykkC-yxkD leader 471855005068 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 471855005069 putative efflux protein, MATE family; Region: matE; TIGR00797 471855005070 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471855005071 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471855005072 DNA binding residues [nucleotide binding] 471855005073 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 471855005074 magnesium chelatase subunit H; Provisional; Region: PRK12493 471855005075 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471855005076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471855005077 NAD(P) binding site [chemical binding]; other site 471855005078 active site 471855005079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855005080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855005081 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005082 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 471855005083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855005084 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 471855005085 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 471855005086 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 471855005087 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 471855005088 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855005089 YibE/F-like protein; Region: YibE_F; pfam07907 471855005090 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 471855005091 CotH protein; Region: CotH; pfam08757 471855005092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471855005093 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 471855005094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855005095 Walker A motif; other site 471855005096 ATP binding site [chemical binding]; other site 471855005097 Walker B motif; other site 471855005098 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 471855005099 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 471855005100 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 471855005101 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 471855005102 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 471855005103 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471855005104 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855005105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855005106 DNA binding residues [nucleotide binding] 471855005107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471855005108 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 471855005109 Walker A/P-loop; other site 471855005110 ATP binding site [chemical binding]; other site 471855005111 Q-loop/lid; other site 471855005112 ABC transporter signature motif; other site 471855005113 Walker B; other site 471855005114 D-loop; other site 471855005115 H-loop/switch region; other site 471855005116 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471855005117 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 471855005118 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 471855005119 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471855005120 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471855005121 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471855005122 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855005123 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855005124 Helix-turn-helix domain; Region: HTH_36; pfam13730 471855005125 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 471855005126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855005127 Walker A motif; other site 471855005128 ATP binding site [chemical binding]; other site 471855005129 Walker B motif; other site 471855005130 arginine finger; other site 471855005131 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 471855005132 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471855005133 Walker A motif; other site 471855005134 ATP binding site [chemical binding]; other site 471855005135 Walker B motif; other site 471855005136 PrgI family protein; Region: PrgI; pfam12666 471855005137 AAA-like domain; Region: AAA_10; pfam12846 471855005138 Domain of unknown function DUF87; Region: DUF87; pfam01935 471855005139 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 471855005140 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855005141 NlpC/P60 family; Region: NLPC_P60; pfam00877 471855005142 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855005143 NlpC/P60 family; Region: NLPC_P60; cl17555 471855005144 Cna protein B-type domain; Region: Cna_B; pfam05738 471855005145 Abortive infection C-terminus; Region: Abi_C; pfam14355 471855005146 rod-share determining protein MreBH; Provisional; Region: PRK13929 471855005147 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 471855005148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304 471855005149 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471855005150 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471855005151 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855005152 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471855005153 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855005154 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471855005155 Protein of unknown function DUF262; Region: DUF262; pfam03235 471855005156 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 471855005157 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471855005158 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471855005159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855005160 ATP binding site [chemical binding]; other site 471855005161 putative Mg++ binding site [ion binding]; other site 471855005162 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 471855005163 integrase; Provisional; Region: int; PHA02601 471855005164 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471855005165 Int/Topo IB signature motif; other site 471855005166 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 471855005167 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855005168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855005169 non-specific DNA binding site [nucleotide binding]; other site 471855005170 salt bridge; other site 471855005171 sequence-specific DNA binding site [nucleotide binding]; other site 471855005172 GMP synthase; Reviewed; Region: guaA; PRK00074 471855005173 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471855005174 AMP/PPi binding site [chemical binding]; other site 471855005175 candidate oxyanion hole; other site 471855005176 catalytic triad [active] 471855005177 potential glutamine specificity residues [chemical binding]; other site 471855005178 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471855005179 ATP Binding subdomain [chemical binding]; other site 471855005180 Ligand Binding sites [chemical binding]; other site 471855005181 Dimerization subdomain; other site 471855005182 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 471855005183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 471855005184 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 471855005185 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 471855005186 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 471855005187 catalytic triad [active] 471855005188 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 471855005189 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471855005190 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471855005191 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855005192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855005193 active site 471855005194 phosphorylation site [posttranslational modification] 471855005195 intermolecular recognition site; other site 471855005196 dimerization interface [polypeptide binding]; other site 471855005197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855005198 DNA binding residues [nucleotide binding] 471855005199 dimerization interface [polypeptide binding]; other site 471855005200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471855005201 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 471855005202 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471855005203 Cation efflux family; Region: Cation_efflux; pfam01545 471855005204 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471855005205 metal binding site 2 [ion binding]; metal-binding site 471855005206 putative DNA binding helix; other site 471855005207 metal binding site 1 [ion binding]; metal-binding site 471855005208 dimer interface [polypeptide binding]; other site 471855005209 structural Zn2+ binding site [ion binding]; other site 471855005210 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 471855005211 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 471855005212 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 471855005213 putative catalytic cysteine [active] 471855005214 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 471855005215 Uncharacterized conserved protein [Function unknown]; Region: COG1434 471855005216 putative active site [active] 471855005217 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855005218 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471855005219 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855005220 MarR family; Region: MarR_2; pfam12802 471855005221 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855005222 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471855005223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855005224 Walker A/P-loop; other site 471855005225 ATP binding site [chemical binding]; other site 471855005226 Q-loop/lid; other site 471855005227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855005228 ABC transporter signature motif; other site 471855005229 Walker B; other site 471855005230 D-loop; other site 471855005231 H-loop/switch region; other site 471855005232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855005233 AAA domain; Region: AAA_21; pfam13304 471855005234 Walker A/P-loop; other site 471855005235 ATP binding site [chemical binding]; other site 471855005236 Q-loop/lid; other site 471855005237 ABC transporter signature motif; other site 471855005238 Walker B; other site 471855005239 D-loop; other site 471855005240 H-loop/switch region; other site 471855005241 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 471855005242 active site residue [active] 471855005243 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 471855005244 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855005245 active site 471855005246 metal binding site [ion binding]; metal-binding site 471855005247 homotetramer interface [polypeptide binding]; other site 471855005248 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 471855005249 YacP-like NYN domain; Region: NYN_YacP; pfam05991 471855005250 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471855005251 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471855005252 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471855005253 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471855005254 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471855005255 active site 471855005256 HIGH motif; other site 471855005257 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471855005258 KMSKS motif; other site 471855005259 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471855005260 tRNA binding surface [nucleotide binding]; other site 471855005261 anticodon binding site; other site 471855005262 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 471855005263 homotrimer interaction site [polypeptide binding]; other site 471855005264 zinc binding site [ion binding]; other site 471855005265 CDP-binding sites; other site 471855005266 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471855005267 substrate binding site; other site 471855005268 dimer interface; other site 471855005269 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471855005270 Clp amino terminal domain; Region: Clp_N; pfam02861 471855005271 Clp amino terminal domain; Region: Clp_N; pfam02861 471855005272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855005273 Walker A motif; other site 471855005274 ATP binding site [chemical binding]; other site 471855005275 Walker B motif; other site 471855005276 arginine finger; other site 471855005277 UvrB/uvrC motif; Region: UVR; pfam02151 471855005278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855005279 Walker A motif; other site 471855005280 ATP binding site [chemical binding]; other site 471855005281 Walker B motif; other site 471855005282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471855005283 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471855005284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471855005285 dimer interface [polypeptide binding]; other site 471855005286 putative anticodon binding site; other site 471855005287 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 471855005288 motif 1; other site 471855005289 active site 471855005290 motif 2; other site 471855005291 motif 3; other site 471855005292 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471855005293 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471855005294 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471855005295 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471855005296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 471855005297 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855005298 NlpC/P60 family; Region: NLPC_P60; cl17555 471855005299 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 471855005300 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 471855005301 B12 binding site [chemical binding]; other site 471855005302 cobalt ligand [ion binding]; other site 471855005303 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 471855005304 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 471855005305 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 471855005306 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 471855005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855005308 dimer interface [polypeptide binding]; other site 471855005309 conserved gate region; other site 471855005310 ABC-ATPase subunit interface; other site 471855005311 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 471855005312 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471855005313 Walker A/P-loop; other site 471855005314 ATP binding site [chemical binding]; other site 471855005315 Q-loop/lid; other site 471855005316 ABC transporter signature motif; other site 471855005317 Walker B; other site 471855005318 D-loop; other site 471855005319 H-loop/switch region; other site 471855005320 NIL domain; Region: NIL; cl09633 471855005321 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855005322 NlpC/P60 family; Region: NLPC_P60; pfam00877 471855005323 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471855005324 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471855005325 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471855005326 substrate binding pocket [chemical binding]; other site 471855005327 chain length determination region; other site 471855005328 substrate-Mg2+ binding site; other site 471855005329 catalytic residues [active] 471855005330 aspartate-rich region 1; other site 471855005331 active site lid residues [active] 471855005332 aspartate-rich region 2; other site 471855005333 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471855005334 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471855005335 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 471855005336 enolase; Provisional; Region: eno; PRK00077 471855005337 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471855005338 dimer interface [polypeptide binding]; other site 471855005339 metal binding site [ion binding]; metal-binding site 471855005340 substrate binding pocket [chemical binding]; other site 471855005341 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855005342 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471855005343 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471855005344 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471855005345 alphaNTD - beta interaction site [polypeptide binding]; other site 471855005346 alphaNTD homodimer interface [polypeptide binding]; other site 471855005347 alphaNTD - beta' interaction site [polypeptide binding]; other site 471855005348 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471855005349 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471855005350 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471855005351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471855005352 RNA binding surface [nucleotide binding]; other site 471855005353 30S ribosomal protein S11; Validated; Region: PRK05309 471855005354 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471855005355 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471855005356 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 471855005357 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471855005358 rRNA binding site [nucleotide binding]; other site 471855005359 predicted 30S ribosome binding site; other site 471855005360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471855005361 Ligand Binding Site [chemical binding]; other site 471855005362 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 471855005363 aldolase; Validated; Region: PRK06852 471855005364 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 471855005365 catalytic residue [active] 471855005366 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 471855005367 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471855005368 homodimer interface [polypeptide binding]; other site 471855005369 NAD binding pocket [chemical binding]; other site 471855005370 ATP binding pocket [chemical binding]; other site 471855005371 Mg binding site [ion binding]; other site 471855005372 active-site loop [active] 471855005373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855005374 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 471855005375 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 471855005376 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 471855005377 FeoA domain; Region: FeoA; pfam04023 471855005378 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471855005379 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471855005380 putative NADH binding site [chemical binding]; other site 471855005381 putative active site [active] 471855005382 nudix motif; other site 471855005383 putative metal binding site [ion binding]; other site 471855005384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855005385 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855005386 DNA binding site [nucleotide binding] 471855005387 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471855005388 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471855005389 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471855005390 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 471855005391 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 471855005392 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471855005393 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 471855005394 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471855005395 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471855005396 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471855005397 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471855005398 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 471855005399 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 471855005400 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471855005401 DNA binding site [nucleotide binding] 471855005402 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471855005403 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471855005404 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471855005405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471855005406 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 471855005407 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 471855005408 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 471855005409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471855005410 RPB1 interaction site [polypeptide binding]; other site 471855005411 RPB10 interaction site [polypeptide binding]; other site 471855005412 RPB11 interaction site [polypeptide binding]; other site 471855005413 RPB3 interaction site [polypeptide binding]; other site 471855005414 RPB12 interaction site [polypeptide binding]; other site 471855005415 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855005416 EamA-like transporter family; Region: EamA; pfam00892 471855005417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855005418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855005419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855005420 dimerization interface [polypeptide binding]; other site 471855005421 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471855005422 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 471855005423 putative dimer interface [polypeptide binding]; other site 471855005424 excinuclease ABC subunit B; Provisional; Region: PRK05298 471855005425 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855005426 ATP binding site [chemical binding]; other site 471855005427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855005428 nucleotide binding region [chemical binding]; other site 471855005429 ATP-binding site [chemical binding]; other site 471855005430 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471855005431 UvrB/uvrC motif; Region: UVR; pfam02151 471855005432 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471855005433 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471855005434 nucleotide binding site [chemical binding]; other site 471855005435 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471855005436 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471855005437 CoA-binding site [chemical binding]; other site 471855005438 ATP-binding [chemical binding]; other site 471855005439 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471855005440 RNA binding site [nucleotide binding]; other site 471855005441 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471855005442 RNA binding site [nucleotide binding]; other site 471855005443 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471855005444 RNA binding site [nucleotide binding]; other site 471855005445 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 471855005446 RNA binding site [nucleotide binding]; other site 471855005447 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471855005448 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471855005449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471855005450 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 471855005451 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 471855005452 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 471855005453 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471855005454 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471855005455 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 471855005456 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 471855005457 G1 box; other site 471855005458 GTP/Mg2+ binding site [chemical binding]; other site 471855005459 Switch I region; other site 471855005460 G2 box; other site 471855005461 G3 box; other site 471855005462 Switch II region; other site 471855005463 G4 box; other site 471855005464 G5 box; other site 471855005465 Nucleoside recognition; Region: Gate; pfam07670 471855005466 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 471855005467 Nucleoside recognition; Region: Gate; pfam07670 471855005468 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 471855005469 FeoA domain; Region: FeoA; pfam04023 471855005470 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 471855005471 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 471855005472 TadE-like protein; Region: TadE; pfam07811 471855005473 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471855005474 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471855005475 catalytic residues [active] 471855005476 catalytic nucleophile [active] 471855005477 Recombinase; Region: Recombinase; pfam07508 471855005478 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471855005479 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471855005480 ssDNA binding site [nucleotide binding]; other site 471855005481 dimer interface [polypeptide binding]; other site 471855005482 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471855005483 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 471855005484 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 471855005485 HSP70 interaction site [polypeptide binding]; other site 471855005486 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 471855005487 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855005488 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855005489 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471855005490 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471855005491 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 471855005492 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855005493 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 471855005494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471855005495 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 471855005496 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471855005497 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471855005498 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471855005499 catalytic residues [active] 471855005500 catalytic nucleophile [active] 471855005501 Recombinase; Region: Recombinase; pfam07508 471855005502 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 471855005503 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471855005504 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 471855005505 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471855005506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855005507 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471855005508 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 471855005509 catalytic residues [active] 471855005510 catalytic nucleophile [active] 471855005511 Presynaptic Site I dimer interface [polypeptide binding]; other site 471855005512 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 471855005513 Synaptic Flat tetramer interface [polypeptide binding]; other site 471855005514 Synaptic Site I dimer interface [polypeptide binding]; other site 471855005515 DNA binding site [nucleotide binding] 471855005516 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 471855005517 DNA-binding interface [nucleotide binding]; DNA binding site 471855005518 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 471855005519 Antirestriction protein (ArdA); Region: ArdA; cl01953 471855005520 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 471855005521 putative active site [active] 471855005522 putative metal binding site [ion binding]; other site 471855005523 DNA protecting protein DprA; Region: dprA; TIGR00732 471855005524 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 471855005525 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 471855005526 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471855005527 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 471855005528 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471855005529 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471855005530 ssDNA binding site [nucleotide binding]; other site 471855005531 dimer interface [polypeptide binding]; other site 471855005532 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471855005533 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 471855005534 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 471855005535 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471855005536 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471855005537 P-loop; other site 471855005538 Magnesium ion binding site [ion binding]; other site 471855005539 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855005540 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 471855005541 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471855005542 Walker A motif; other site 471855005543 AAA domain; Region: AAA_31; pfam13614 471855005544 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 471855005545 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 471855005546 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471855005547 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471855005548 dimer interface [polypeptide binding]; other site 471855005549 anticodon binding site; other site 471855005550 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471855005551 homodimer interface [polypeptide binding]; other site 471855005552 motif 1; other site 471855005553 active site 471855005554 motif 2; other site 471855005555 GAD domain; Region: GAD; pfam02938 471855005556 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471855005557 active site 471855005558 motif 3; other site 471855005559 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471855005560 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471855005561 dimer interface [polypeptide binding]; other site 471855005562 motif 1; other site 471855005563 active site 471855005564 motif 2; other site 471855005565 motif 3; other site 471855005566 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471855005567 anticodon binding site; other site 471855005568 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 471855005569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471855005570 Peptidase M16C associated; Region: M16C_assoc; pfam08367 471855005571 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471855005572 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855005573 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471855005574 Predicted ATPase [General function prediction only]; Region: COG3910 471855005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855005576 Walker A/P-loop; other site 471855005577 ATP binding site [chemical binding]; other site 471855005578 Q-loop/lid; other site 471855005579 ABC transporter signature motif; other site 471855005580 Walker B; other site 471855005581 D-loop; other site 471855005582 H-loop/switch region; other site 471855005583 hypothetical protein; Provisional; Region: PRK13663 471855005584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 471855005585 Flavin Reductases; Region: FlaRed; cl00801 471855005586 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 471855005587 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471855005588 Cation efflux family; Region: Cation_efflux; cl00316 471855005589 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855005590 MarR family; Region: MarR; pfam01047 471855005591 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 471855005592 catalytic residues [active] 471855005593 dimer interface [polypeptide binding]; other site 471855005594 E3 Ubiquitin ligase; Region: GIDE; pfam12483 471855005595 phage shock protein A; Region: phageshock_pspA; TIGR02977 471855005596 Predicted membrane protein [Function unknown]; Region: COG2364 471855005597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471855005598 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 471855005599 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471855005600 active site 471855005601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471855005602 non-specific DNA binding site [nucleotide binding]; other site 471855005603 salt bridge; other site 471855005604 sequence-specific DNA binding site [nucleotide binding]; other site 471855005605 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855005606 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855005607 DNA binding residues [nucleotide binding] 471855005608 dimerization interface [polypeptide binding]; other site 471855005609 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855005610 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005611 molybdopterin cofactor binding site; other site 471855005612 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005613 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 471855005614 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855005615 molybdopterin cofactor binding site; other site 471855005616 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855005617 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855005618 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 471855005619 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471855005620 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471855005621 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471855005622 homodecamer interface [polypeptide binding]; other site 471855005623 GTP cyclohydrolase I; Provisional; Region: PLN03044 471855005624 active site 471855005625 putative catalytic site residues [active] 471855005626 zinc binding site [ion binding]; other site 471855005627 GTP-CH-I/GFRP interaction surface; other site 471855005628 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 471855005629 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471855005630 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471855005631 homodimer interface [polypeptide binding]; other site 471855005632 NADP binding site [chemical binding]; other site 471855005633 substrate binding site [chemical binding]; other site 471855005634 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 471855005635 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 471855005636 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855005637 motif II; other site 471855005638 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471855005639 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471855005640 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471855005641 Phospholipid methyltransferase; Region: PEMT; cl17370 471855005642 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 471855005643 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 471855005644 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 471855005645 Potassium binding sites [ion binding]; other site 471855005646 Cesium cation binding sites [ion binding]; other site 471855005647 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 471855005648 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471855005649 CoenzymeA binding site [chemical binding]; other site 471855005650 subunit interaction site [polypeptide binding]; other site 471855005651 PHB binding site; other site 471855005652 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 471855005653 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 471855005654 putative ADP-ribose binding site [chemical binding]; other site 471855005655 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471855005656 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471855005657 ApbE family; Region: ApbE; pfam02424 471855005658 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 471855005659 GIY-YIG motif/motif A; other site 471855005660 putative active site [active] 471855005661 putative metal binding site [ion binding]; other site 471855005662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855005663 catalytic core [active] 471855005664 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471855005665 active site 471855005666 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 471855005667 cobalamin synthase; Reviewed; Region: cobS; PRK00235 471855005668 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 471855005669 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 471855005670 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 471855005671 active site pocket [active] 471855005672 putative dimer interface [polypeptide binding]; other site 471855005673 putative cataytic base [active] 471855005674 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 471855005675 Precorrin-8X methylmutase; Region: CbiC; pfam02570 471855005676 cobyric acid synthase; Provisional; Region: PRK00784 471855005677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855005678 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855005679 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 471855005680 catalytic triad [active] 471855005681 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 471855005682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855005683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855005684 homodimer interface [polypeptide binding]; other site 471855005685 catalytic residue [active] 471855005686 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 471855005687 Uncharacterized conserved protein [Function unknown]; Region: COG2014 471855005688 Domain of unknown function (DUF364); Region: DUF364; pfam04016 471855005689 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 471855005690 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 471855005691 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855005692 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 471855005693 catalytic triad [active] 471855005694 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 471855005695 active site 471855005696 putative homodimer interface [polypeptide binding]; other site 471855005697 SAM binding site [chemical binding]; other site 471855005698 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 471855005699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855005700 S-adenosylmethionine binding site [chemical binding]; other site 471855005701 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 471855005702 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 471855005703 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 471855005704 active site 471855005705 SAM binding site [chemical binding]; other site 471855005706 homodimer interface [polypeptide binding]; other site 471855005707 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 471855005708 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 471855005709 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 471855005710 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 471855005711 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 471855005712 active site 471855005713 SAM binding site [chemical binding]; other site 471855005714 homodimer interface [polypeptide binding]; other site 471855005715 Cysteine-rich small domain; Region: zf-like; cl00946 471855005716 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 471855005717 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 471855005718 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471855005719 N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cl02206 471855005720 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 471855005721 ApbE family; Region: ApbE; pfam02424 471855005722 FMN-binding domain; Region: FMN_bind; cl01081 471855005723 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 471855005724 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 471855005725 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 471855005726 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 471855005727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471855005728 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471855005729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855005730 putative substrate translocation pore; other site 471855005731 Permease family; Region: Xan_ur_permease; pfam00860 471855005732 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471855005733 Na2 binding site [ion binding]; other site 471855005734 putative substrate binding site 1 [chemical binding]; other site 471855005735 Na binding site 1 [ion binding]; other site 471855005736 putative substrate binding site 2 [chemical binding]; other site 471855005737 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471855005738 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471855005739 dimerization interface 3.5A [polypeptide binding]; other site 471855005740 active site 471855005741 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471855005742 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471855005743 active site 471855005744 PHP Thumb interface [polypeptide binding]; other site 471855005745 metal binding site [ion binding]; metal-binding site 471855005746 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471855005747 generic binding surface II; other site 471855005748 generic binding surface I; other site 471855005749 SEC-C motif; Region: SEC-C; pfam02810 471855005750 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 471855005751 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471855005752 gamma subunit interface [polypeptide binding]; other site 471855005753 epsilon subunit interface [polypeptide binding]; other site 471855005754 LBP interface [polypeptide binding]; other site 471855005755 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471855005756 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471855005757 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471855005758 alpha subunit interaction interface [polypeptide binding]; other site 471855005759 Walker A motif; other site 471855005760 ATP binding site [chemical binding]; other site 471855005761 Walker B motif; other site 471855005762 inhibitor binding site; inhibition site 471855005763 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471855005764 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471855005765 core domain interface [polypeptide binding]; other site 471855005766 delta subunit interface [polypeptide binding]; other site 471855005767 epsilon subunit interface [polypeptide binding]; other site 471855005768 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471855005769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471855005770 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471855005771 beta subunit interaction interface [polypeptide binding]; other site 471855005772 Walker A motif; other site 471855005773 ATP binding site [chemical binding]; other site 471855005774 Walker B motif; other site 471855005775 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471855005776 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 471855005777 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471855005778 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 471855005779 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471855005780 ATP synthase subunit C; Region: ATP-synt_C; cl00466 471855005781 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 471855005782 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 471855005783 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 471855005784 catalytic motif [active] 471855005785 Zn binding site [ion binding]; other site 471855005786 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471855005787 homotrimer interaction site [polypeptide binding]; other site 471855005788 putative active site [active] 471855005789 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 471855005790 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 471855005791 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 471855005792 Uncharacterized membrane protein [Function unknown]; Region: COG3949 471855005793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855005794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005795 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471855005796 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471855005797 dimer interface [polypeptide binding]; other site 471855005798 active site 471855005799 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471855005800 folate binding site [chemical binding]; other site 471855005801 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 471855005802 glycerol kinase; Provisional; Region: glpK; PRK00047 471855005803 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 471855005804 N- and C-terminal domain interface [polypeptide binding]; other site 471855005805 active site 471855005806 MgATP binding site [chemical binding]; other site 471855005807 catalytic site [active] 471855005808 metal binding site [ion binding]; metal-binding site 471855005809 glycerol binding site [chemical binding]; other site 471855005810 homotetramer interface [polypeptide binding]; other site 471855005811 homodimer interface [polypeptide binding]; other site 471855005812 FBP binding site [chemical binding]; other site 471855005813 protein IIAGlc interface [polypeptide binding]; other site 471855005814 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471855005815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471855005816 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471855005817 Predicted membrane protein [Function unknown]; Region: COG1971 471855005818 Domain of unknown function DUF; Region: DUF204; pfam02659 471855005819 endonuclease IV; Provisional; Region: PRK01060 471855005820 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 471855005821 AP (apurinic/apyrimidinic) site pocket; other site 471855005822 DNA interaction; other site 471855005823 Metal-binding active site; metal-binding site 471855005824 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 471855005825 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471855005826 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 471855005827 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471855005828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855005829 active site 471855005830 ATP binding site [chemical binding]; other site 471855005831 substrate binding site [chemical binding]; other site 471855005832 activation loop (A-loop); other site 471855005833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855005834 active site 471855005835 ATP binding site [chemical binding]; other site 471855005836 substrate binding site [chemical binding]; other site 471855005837 activation loop (A-loop); other site 471855005838 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855005839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005840 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471855005841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471855005842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855005843 motif II; other site 471855005844 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471855005845 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471855005846 GatB domain; Region: GatB_Yqey; smart00845 471855005847 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471855005848 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471855005849 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471855005850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855005851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005852 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 471855005853 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 471855005854 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 471855005855 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 471855005856 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855005857 4Fe-4S binding domain; Region: Fer4; pfam00037 471855005858 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005859 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005860 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005861 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 471855005862 molybdopterin cofactor binding site; other site 471855005863 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005864 GTP-binding protein YchF; Reviewed; Region: PRK09601 471855005865 YchF GTPase; Region: YchF; cd01900 471855005866 G1 box; other site 471855005867 GTP/Mg2+ binding site [chemical binding]; other site 471855005868 Switch I region; other site 471855005869 G2 box; other site 471855005870 Switch II region; other site 471855005871 G3 box; other site 471855005872 G4 box; other site 471855005873 G5 box; other site 471855005874 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471855005875 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471855005876 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855005877 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471855005878 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855005879 Zn2+ binding site [ion binding]; other site 471855005880 Mg2+ binding site [ion binding]; other site 471855005881 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471855005882 synthetase active site [active] 471855005883 NTP binding site [chemical binding]; other site 471855005884 metal binding site [ion binding]; metal-binding site 471855005885 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471855005886 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471855005887 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 471855005888 DHH family; Region: DHH; pfam01368 471855005889 DHHA1 domain; Region: DHHA1; pfam02272 471855005890 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471855005891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471855005892 ATP binding site [chemical binding]; other site 471855005893 putative Mg++ binding site [ion binding]; other site 471855005894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855005895 nucleotide binding region [chemical binding]; other site 471855005896 ATP-binding site [chemical binding]; other site 471855005897 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471855005898 putative active site [active] 471855005899 catalytic residue [active] 471855005900 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 471855005901 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471855005902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471855005903 active site 471855005904 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 471855005905 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471855005906 Substrate binding site; other site 471855005907 Mg++ binding site; other site 471855005908 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471855005909 active site 471855005910 substrate binding site [chemical binding]; other site 471855005911 CoA binding site [chemical binding]; other site 471855005912 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 471855005913 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471855005914 active site 471855005915 substrate binding site [chemical binding]; other site 471855005916 metal binding site [ion binding]; metal-binding site 471855005917 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 471855005918 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855005919 Double zinc ribbon; Region: DZR; pfam12773 471855005920 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471855005921 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471855005922 23S rRNA interface [nucleotide binding]; other site 471855005923 L3 interface [polypeptide binding]; other site 471855005924 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471855005925 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471855005926 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471855005927 heterotetramer interface [polypeptide binding]; other site 471855005928 active site pocket [active] 471855005929 cleavage site 471855005930 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 471855005931 feedback inhibition sensing region; other site 471855005932 homohexameric interface [polypeptide binding]; other site 471855005933 nucleotide binding site [chemical binding]; other site 471855005934 N-acetyl-L-glutamate binding site [chemical binding]; other site 471855005935 acetylornithine aminotransferase; Provisional; Region: PRK02627 471855005936 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471855005937 inhibitor-cofactor binding pocket; inhibition site 471855005938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855005939 catalytic residue [active] 471855005940 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 471855005941 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471855005942 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 471855005943 CAAX protease self-immunity; Region: Abi; pfam02517 471855005944 CAAX protease self-immunity; Region: Abi; pfam02517 471855005945 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 471855005946 Isochorismatase family; Region: Isochorismatase; pfam00857 471855005947 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 471855005948 catalytic triad [active] 471855005949 conserved cis-peptide bond; other site 471855005950 DNA polymerase IV; Reviewed; Region: PRK03103 471855005951 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471855005952 active site 471855005953 DNA binding site [nucleotide binding] 471855005954 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 471855005955 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471855005956 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 471855005957 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471855005958 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471855005959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471855005960 DNA binding residues [nucleotide binding] 471855005961 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471855005962 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471855005963 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471855005964 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471855005965 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 471855005966 Domain of unknown function DUF87; Region: DUF87; pfam01935 471855005967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855005968 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855005969 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855005970 molybdopterin cofactor binding site; other site 471855005971 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855005972 molybdopterin cofactor binding site; other site 471855005973 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855005974 4Fe-4S binding domain; Region: Fer4; cl02805 471855005975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471855005976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855005977 dimerization interface [polypeptide binding]; other site 471855005978 putative Zn2+ binding site [ion binding]; other site 471855005979 putative DNA binding site [nucleotide binding]; other site 471855005980 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855005981 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471855005982 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855005983 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855005984 ABC transporter; Region: ABC_tran_2; pfam12848 471855005985 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471855005986 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471855005987 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471855005988 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471855005989 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471855005990 active site 471855005991 catalytic residues [active] 471855005992 metal binding site [ion binding]; metal-binding site 471855005993 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471855005994 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 471855005995 transaminase; Validated; Region: PRK07324 471855005996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855005997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855005998 homodimer interface [polypeptide binding]; other site 471855005999 catalytic residue [active] 471855006000 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 471855006001 arginine deiminase; Provisional; Region: PRK01388 471855006002 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471855006003 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471855006004 nudix motif; other site 471855006005 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 471855006006 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 471855006007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855006008 Zn2+ binding site [ion binding]; other site 471855006009 Mg2+ binding site [ion binding]; other site 471855006010 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 471855006011 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 471855006012 Ligand Binding Site [chemical binding]; other site 471855006013 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 471855006014 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855006015 Double zinc ribbon; Region: DZR; pfam12773 471855006016 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471855006017 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 471855006018 ligand binding surface [chemical binding]; other site 471855006019 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471855006020 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471855006021 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 471855006022 Double zinc ribbon; Region: DZR; pfam12773 471855006023 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855006024 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855006025 YARHG domain; Region: YARHG; pfam13308 471855006026 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471855006027 amidase catalytic site [active] 471855006028 Zn binding residues [ion binding]; other site 471855006029 substrate binding site [chemical binding]; other site 471855006030 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855006031 Sel1-like repeats; Region: SEL1; smart00671 471855006032 Sel1 repeat; Region: Sel1; cl02723 471855006033 WYL domain; Region: WYL; pfam13280 471855006034 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 471855006035 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855006036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855006037 acyl-activating enzyme (AAE) consensus motif; other site 471855006038 acyl-activating enzyme (AAE) consensus motif; other site 471855006039 AMP binding site [chemical binding]; other site 471855006040 active site 471855006041 CoA binding site [chemical binding]; other site 471855006042 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 471855006043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006044 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006045 FMN-binding domain; Region: FMN_bind; cl01081 471855006046 Predicted oxidoreductase [General function prediction only]; Region: COG3573 471855006047 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855006048 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471855006049 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471855006050 catalytic residues [active] 471855006051 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 471855006052 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 471855006053 serine O-acetyltransferase; Region: cysE; TIGR01172 471855006054 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471855006055 trimer interface [polypeptide binding]; other site 471855006056 active site 471855006057 substrate binding site [chemical binding]; other site 471855006058 CoA binding site [chemical binding]; other site 471855006059 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471855006060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006061 putative substrate translocation pore; other site 471855006062 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471855006063 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471855006064 dimer interface [polypeptide binding]; other site 471855006065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855006066 catalytic residue [active] 471855006067 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471855006068 Na2 binding site [ion binding]; other site 471855006069 putative substrate binding site 1 [chemical binding]; other site 471855006070 Na binding site 1 [ion binding]; other site 471855006071 putative substrate binding site 2 [chemical binding]; other site 471855006072 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 471855006073 4Fe-4S binding domain; Region: Fer4; pfam00037 471855006074 4Fe-4S binding domain; Region: Fer4; pfam00037 471855006075 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855006076 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471855006077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006079 DNA binding residues [nucleotide binding] 471855006080 dimerization interface [polypeptide binding]; other site 471855006081 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855006082 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855006083 molybdopterin cofactor binding site; other site 471855006084 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855006085 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855006086 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855006087 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 471855006088 putative molybdopterin cofactor binding site; other site 471855006089 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855006090 4Fe-4S binding domain; Region: Fer4; pfam00037 471855006091 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 471855006092 4Fe-4S binding domain; Region: Fer4_5; pfam12801 471855006093 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 471855006094 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855006095 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855006096 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 471855006097 Predicted deacylase [General function prediction only]; Region: COG3608 471855006098 active site 471855006099 Zn binding site [ion binding]; other site 471855006100 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 471855006101 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 471855006102 active site 471855006103 Zn binding site [ion binding]; other site 471855006104 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471855006105 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471855006106 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471855006107 potential frameshift: common BLAST hit: gi|213693059|ref|YP_002323645.1| protein of unknown function DUF404 471855006108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 471855006109 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 471855006110 Membrane protein of unknown function; Region: DUF360; pfam04020 471855006111 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471855006112 Amidinotransferase; Region: Amidinotransf; cl12043 471855006113 helicase 45; Provisional; Region: PTZ00424 471855006114 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471855006115 ATP binding site [chemical binding]; other site 471855006116 Mg++ binding site [ion binding]; other site 471855006117 motif III; other site 471855006118 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471855006119 nucleotide binding region [chemical binding]; other site 471855006120 ATP-binding site [chemical binding]; other site 471855006121 LytTr DNA-binding domain; Region: LytTR; smart00850 471855006122 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855006123 domain interaction interfaces [polypeptide binding]; other site 471855006124 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471855006125 active site 471855006126 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471855006127 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 471855006128 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 471855006129 putative RNA binding site [nucleotide binding]; other site 471855006130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855006131 S-adenosylmethionine binding site [chemical binding]; other site 471855006132 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 471855006133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471855006134 active site 471855006135 nucleotide binding site [chemical binding]; other site 471855006136 HIGH motif; other site 471855006137 KMSKS motif; other site 471855006138 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471855006139 anticodon binding site; other site 471855006140 tRNA binding surface [nucleotide binding]; other site 471855006141 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 471855006142 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 471855006143 tandem repeat interface [polypeptide binding]; other site 471855006144 oligomer interface [polypeptide binding]; other site 471855006145 active site residues [active] 471855006146 Predicted integral membrane protein [Function unknown]; Region: COG5652 471855006147 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471855006148 FMN binding site [chemical binding]; other site 471855006149 dimer interface [polypeptide binding]; other site 471855006150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855006151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855006152 dimer interface [polypeptide binding]; other site 471855006153 phosphorylation site [posttranslational modification] 471855006154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855006155 ATP binding site [chemical binding]; other site 471855006156 Mg2+ binding site [ion binding]; other site 471855006157 G-X-G motif; other site 471855006158 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855006159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855006160 active site 471855006161 phosphorylation site [posttranslational modification] 471855006162 intermolecular recognition site; other site 471855006163 dimerization interface [polypeptide binding]; other site 471855006164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471855006165 DNA binding site [nucleotide binding] 471855006166 Protein of unknown function (DUF975); Region: DUF975; cl10504 471855006167 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855006168 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 471855006169 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 471855006170 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471855006171 YCII-related domain; Region: YCII; cl00999 471855006172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006174 DNA binding residues [nucleotide binding] 471855006175 dimerization interface [polypeptide binding]; other site 471855006176 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471855006177 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471855006178 Moco binding site; other site 471855006179 metal coordination site [ion binding]; other site 471855006180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006182 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855006183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855006184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006185 Walker A/P-loop; other site 471855006186 ATP binding site [chemical binding]; other site 471855006187 Q-loop/lid; other site 471855006188 ABC transporter signature motif; other site 471855006189 Walker B; other site 471855006190 D-loop; other site 471855006191 H-loop/switch region; other site 471855006192 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855006193 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855006194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006195 Walker A/P-loop; other site 471855006196 ATP binding site [chemical binding]; other site 471855006197 Q-loop/lid; other site 471855006198 ABC transporter signature motif; other site 471855006199 Walker B; other site 471855006200 D-loop; other site 471855006201 H-loop/switch region; other site 471855006202 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 471855006203 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855006204 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855006205 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855006206 Walker A/P-loop; other site 471855006207 ATP binding site [chemical binding]; other site 471855006208 Q-loop/lid; other site 471855006209 ABC transporter signature motif; other site 471855006210 Walker B; other site 471855006211 D-loop; other site 471855006212 H-loop/switch region; other site 471855006213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006214 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471855006215 Walker A/P-loop; other site 471855006216 ATP binding site [chemical binding]; other site 471855006217 Q-loop/lid; other site 471855006218 ABC transporter signature motif; other site 471855006219 Walker B; other site 471855006220 D-loop; other site 471855006221 H-loop/switch region; other site 471855006222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006223 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006224 DNA binding residues [nucleotide binding] 471855006225 dimerization interface [polypeptide binding]; other site 471855006226 FAD dependent oxidoreductase; Region: DAO; pfam01266 471855006227 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855006228 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855006229 EamA-like transporter family; Region: EamA; pfam00892 471855006230 EamA-like transporter family; Region: EamA; cl17759 471855006231 Amino acid permease; Region: AA_permease_2; pfam13520 471855006232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471855006233 catalytic core [active] 471855006234 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 471855006235 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471855006236 active site 471855006237 substrate binding site [chemical binding]; other site 471855006238 metal binding site [ion binding]; metal-binding site 471855006239 Predicted membrane protein [Function unknown]; Region: COG2246 471855006240 GtrA-like protein; Region: GtrA; pfam04138 471855006241 adenylate kinase; Reviewed; Region: adk; PRK00279 471855006242 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471855006243 AMP-binding site [chemical binding]; other site 471855006244 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471855006245 Type III pantothenate kinase; Region: Pan_kinase; cl17198 471855006246 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471855006247 Flavoprotein; Region: Flavoprotein; pfam02441 471855006248 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471855006249 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471855006250 SecY translocase; Region: SecY; pfam00344 471855006251 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471855006252 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471855006253 23S rRNA binding site [nucleotide binding]; other site 471855006254 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471855006255 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471855006256 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471855006257 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471855006258 5S rRNA interface [nucleotide binding]; other site 471855006259 L27 interface [polypeptide binding]; other site 471855006260 23S rRNA interface [nucleotide binding]; other site 471855006261 L5 interface [polypeptide binding]; other site 471855006262 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471855006263 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471855006264 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471855006265 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471855006266 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 471855006267 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471855006268 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471855006269 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471855006270 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471855006271 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471855006272 RNA binding site [nucleotide binding]; other site 471855006273 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471855006274 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471855006275 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471855006276 23S rRNA interface [nucleotide binding]; other site 471855006277 putative translocon interaction site; other site 471855006278 signal recognition particle (SRP54) interaction site; other site 471855006279 L23 interface [polypeptide binding]; other site 471855006280 trigger factor interaction site; other site 471855006281 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471855006282 23S rRNA interface [nucleotide binding]; other site 471855006283 5S rRNA interface [nucleotide binding]; other site 471855006284 putative antibiotic binding site [chemical binding]; other site 471855006285 L25 interface [polypeptide binding]; other site 471855006286 L27 interface [polypeptide binding]; other site 471855006287 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471855006288 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471855006289 G-X-X-G motif; other site 471855006290 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471855006291 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471855006292 putative translocon binding site; other site 471855006293 protein-rRNA interface [nucleotide binding]; other site 471855006294 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471855006295 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471855006296 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471855006297 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471855006298 DNA topoisomerase I; Validated; Region: PRK07219 471855006299 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 471855006300 active site 471855006301 putative interdomain interaction site [polypeptide binding]; other site 471855006302 putative metal-binding site [ion binding]; other site 471855006303 putative nucleotide binding site [chemical binding]; other site 471855006304 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471855006305 domain I; other site 471855006306 DNA binding groove [nucleotide binding] 471855006307 phosphate binding site [ion binding]; other site 471855006308 domain II; other site 471855006309 domain III; other site 471855006310 nucleotide binding site [chemical binding]; other site 471855006311 catalytic site [active] 471855006312 domain IV; other site 471855006313 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 471855006314 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471855006315 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 471855006316 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 471855006317 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 471855006318 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471855006319 substrate binding pocket [chemical binding]; other site 471855006320 dimer interface [polypeptide binding]; other site 471855006321 inhibitor binding site; inhibition site 471855006322 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 471855006323 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 471855006324 B12 binding site [chemical binding]; other site 471855006325 cobalt ligand [ion binding]; other site 471855006326 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 471855006327 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471855006328 FAD binding site [chemical binding]; other site 471855006329 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 471855006330 Peptidase family U32; Region: Peptidase_U32; pfam01136 471855006331 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471855006332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471855006333 Walker A/P-loop; other site 471855006334 ATP binding site [chemical binding]; other site 471855006335 Q-loop/lid; other site 471855006336 ABC transporter signature motif; other site 471855006337 Walker B; other site 471855006338 D-loop; other site 471855006339 H-loop/switch region; other site 471855006340 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471855006341 FtsX-like permease family; Region: FtsX; pfam02687 471855006342 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855006343 Double zinc ribbon; Region: DZR; pfam12773 471855006344 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471855006345 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471855006346 dimer interface [polypeptide binding]; other site 471855006347 motif 1; other site 471855006348 active site 471855006349 motif 2; other site 471855006350 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471855006351 putative deacylase active site [active] 471855006352 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471855006353 active site 471855006354 motif 3; other site 471855006355 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 471855006356 anticodon binding site; other site 471855006357 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471855006358 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471855006359 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471855006360 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471855006361 active site 471855006362 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471855006363 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471855006364 Zn-dependent proteases [General function prediction only]; Region: SpoIVFB; COG1994 471855006365 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471855006366 putative substrate binding region [chemical binding]; other site 471855006367 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471855006368 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471855006369 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471855006370 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471855006371 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471855006372 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471855006373 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471855006374 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471855006375 catalytic residue [active] 471855006376 putative FPP diphosphate binding site; other site 471855006377 putative FPP binding hydrophobic cleft; other site 471855006378 dimer interface [polypeptide binding]; other site 471855006379 putative IPP diphosphate binding site; other site 471855006380 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471855006381 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471855006382 hinge region; other site 471855006383 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471855006384 putative nucleotide binding site [chemical binding]; other site 471855006385 uridine monophosphate binding site [chemical binding]; other site 471855006386 homohexameric interface [polypeptide binding]; other site 471855006387 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471855006388 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471855006389 protein binding site [polypeptide binding]; other site 471855006390 acyl carrier protein; Provisional; Region: acpP; PRK00982 471855006391 TM2 domain; Region: TM2; pfam05154 471855006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855006394 putative substrate translocation pore; other site 471855006395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006396 transcription termination factor Rho; Provisional; Region: rho; PRK09376 471855006397 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471855006398 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 471855006399 RNA binding site [nucleotide binding]; other site 471855006400 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 471855006401 multimer interface [polypeptide binding]; other site 471855006402 Walker A motif; other site 471855006403 ATP binding site [chemical binding]; other site 471855006404 Walker B motif; other site 471855006405 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 471855006406 active site 471855006407 intersubunit interactions; other site 471855006408 catalytic residue [active] 471855006409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855006410 non-specific DNA binding site [nucleotide binding]; other site 471855006411 salt bridge; other site 471855006412 sequence-specific DNA binding site [nucleotide binding]; other site 471855006413 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 471855006414 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 471855006415 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 471855006416 putative ATP binding site [chemical binding]; other site 471855006417 putative substrate interface [chemical binding]; other site 471855006418 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471855006419 active site 1 [active] 471855006420 active site 2 [active] 471855006421 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471855006422 active site 2 [active] 471855006423 active site 1 [active] 471855006424 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 471855006425 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 471855006426 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 471855006427 active site 471855006428 TIGR02452 family protein; Region: TIGR02452 471855006429 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 471855006430 HIRAN domain; Region: HIRAN; pfam08797 471855006431 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471855006432 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 471855006433 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 471855006434 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 471855006435 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 471855006436 putative NAD(P) binding site [chemical binding]; other site 471855006437 active site 471855006438 putative substrate binding site [chemical binding]; other site 471855006439 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471855006440 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471855006441 acyl-activating enzyme (AAE) consensus motif; other site 471855006442 putative AMP binding site [chemical binding]; other site 471855006443 putative active site [active] 471855006444 putative CoA binding site [chemical binding]; other site 471855006445 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 471855006446 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 471855006447 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 471855006448 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 471855006449 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 471855006450 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 471855006451 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 471855006452 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006454 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 471855006455 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 471855006456 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471855006457 EamA-like transporter family; Region: EamA; pfam00892 471855006458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855006459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471855006460 dimer interface [polypeptide binding]; other site 471855006461 phosphorylation site [posttranslational modification] 471855006462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855006463 ATP binding site [chemical binding]; other site 471855006464 Mg2+ binding site [ion binding]; other site 471855006465 G-X-G motif; other site 471855006466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471855006467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471855006468 active site 471855006469 phosphorylation site [posttranslational modification] 471855006470 intermolecular recognition site; other site 471855006471 dimerization interface [polypeptide binding]; other site 471855006472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 471855006473 DNA binding site [nucleotide binding] 471855006474 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471855006475 synthetase active site [active] 471855006476 NTP binding site [chemical binding]; other site 471855006477 metal binding site [ion binding]; metal-binding site 471855006478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855006480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006481 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 471855006482 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471855006483 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471855006484 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 471855006485 active site 471855006486 catalytic triad [active] 471855006487 oxyanion hole [active] 471855006488 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 471855006489 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 471855006490 dimer interface [polypeptide binding]; other site 471855006491 active site 471855006492 Predicted membrane protein [Function unknown]; Region: COG3601 471855006493 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 471855006494 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 471855006495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855006496 Walker A/P-loop; other site 471855006497 ATP binding site [chemical binding]; other site 471855006498 Q-loop/lid; other site 471855006499 ABC transporter signature motif; other site 471855006500 Walker B; other site 471855006501 D-loop; other site 471855006502 H-loop/switch region; other site 471855006503 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 471855006504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855006505 Walker A/P-loop; other site 471855006506 ATP binding site [chemical binding]; other site 471855006507 Q-loop/lid; other site 471855006508 ABC transporter signature motif; other site 471855006509 Walker B; other site 471855006510 D-loop; other site 471855006511 H-loop/switch region; other site 471855006512 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855006513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006515 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471855006516 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 471855006517 active site 471855006518 metal binding site [ion binding]; metal-binding site 471855006519 nudix motif; other site 471855006520 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471855006521 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 471855006522 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 471855006523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855006524 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855006525 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006526 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006527 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471855006528 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 471855006529 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471855006530 NAD(P) binding site [chemical binding]; other site 471855006531 catalytic residues [active] 471855006532 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 471855006533 Na2 binding site [ion binding]; other site 471855006534 putative substrate binding site 1 [chemical binding]; other site 471855006535 Na binding site 1 [ion binding]; other site 471855006536 putative substrate binding site 2 [chemical binding]; other site 471855006537 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 471855006538 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 471855006539 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 471855006540 ligand binding site [chemical binding]; other site 471855006541 homodimer interface [polypeptide binding]; other site 471855006542 NAD(P) binding site [chemical binding]; other site 471855006543 trimer interface B [polypeptide binding]; other site 471855006544 trimer interface A [polypeptide binding]; other site 471855006545 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471855006546 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 471855006547 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 471855006548 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471855006549 FMN binding site [chemical binding]; other site 471855006550 dimer interface [polypeptide binding]; other site 471855006551 RelB antitoxin; Region: RelB; cl01171 471855006552 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 471855006553 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 471855006554 dimerization interface [polypeptide binding]; other site 471855006555 domain crossover interface; other site 471855006556 redox-dependent activation switch; other site 471855006557 PAS fold; Region: PAS_4; pfam08448 471855006558 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 471855006559 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471855006560 metal binding site [ion binding]; metal-binding site 471855006561 active site 471855006562 I-site; other site 471855006563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 471855006564 metal binding site [ion binding]; metal-binding site 471855006565 active site 471855006566 I-site; other site 471855006567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 471855006568 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 471855006569 Bacterial transcriptional activator domain; Region: BTAD; smart01043 471855006570 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471855006571 TPR motif; other site 471855006572 binding surface 471855006573 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 471855006574 metal binding site [ion binding]; metal-binding site 471855006575 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 471855006576 domain interaction interfaces [polypeptide binding]; other site 471855006577 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 471855006578 active site 471855006579 catalytic site [active] 471855006580 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 471855006581 Cna protein B-type domain; Region: Cna_B; pfam05738 471855006582 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855006583 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 471855006584 Cna protein B-type domain; Region: Cna_B; pfam05738 471855006585 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 471855006586 Cna protein B-type domain; Region: Cna_B; pfam05738 471855006587 glycerate kinase; Region: TIGR00045 471855006588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006590 FMN-binding domain; Region: FMN_bind; cl01081 471855006591 hypothetical protein; Validated; Region: PRK07121 471855006592 recombination factor protein RarA; Reviewed; Region: PRK13342 471855006593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471855006594 Walker A motif; other site 471855006595 ATP binding site [chemical binding]; other site 471855006596 Walker B motif; other site 471855006597 arginine finger; other site 471855006598 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471855006599 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 471855006600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471855006601 motif II; other site 471855006602 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 471855006603 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471855006604 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471855006605 Walker A/P-loop; other site 471855006606 ATP binding site [chemical binding]; other site 471855006607 Q-loop/lid; other site 471855006608 ABC transporter signature motif; other site 471855006609 Walker B; other site 471855006610 D-loop; other site 471855006611 H-loop/switch region; other site 471855006612 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471855006613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471855006614 ABC-ATPase subunit interface; other site 471855006615 dimer interface [polypeptide binding]; other site 471855006616 putative PBP binding regions; other site 471855006617 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471855006618 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471855006619 intersubunit interface [polypeptide binding]; other site 471855006620 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 471855006621 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 471855006622 active site 471855006623 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 471855006624 active site 471855006625 N-terminal domain interface [polypeptide binding]; other site 471855006626 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006627 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006628 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855006629 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471855006630 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855006631 FeS/SAM binding site; other site 471855006632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006634 DNA binding residues [nucleotide binding] 471855006635 dimerization interface [polypeptide binding]; other site 471855006636 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855006637 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855006638 molybdopterin cofactor binding site; other site 471855006639 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855006640 molybdopterin cofactor binding site; other site 471855006641 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855006642 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855006643 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855006644 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855006645 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 471855006646 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 471855006647 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471855006648 dimer interface [polypeptide binding]; other site 471855006649 putative functional site; other site 471855006650 putative MPT binding site; other site 471855006651 PBP superfamily domain; Region: PBP_like; pfam12727 471855006652 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471855006653 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471855006654 dimer interface [polypeptide binding]; other site 471855006655 putative functional site; other site 471855006656 putative MPT binding site; other site 471855006657 Fic family protein [Function unknown]; Region: COG3177 471855006658 Fic/DOC family; Region: Fic; pfam02661 471855006659 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 471855006660 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 471855006661 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 471855006662 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 471855006663 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471855006664 MoaE interaction surface [polypeptide binding]; other site 471855006665 MoeB interaction surface [polypeptide binding]; other site 471855006666 thiocarboxylated glycine; other site 471855006667 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 471855006668 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471855006669 putative dimer interface [polypeptide binding]; other site 471855006670 [2Fe-2S] cluster binding site [ion binding]; other site 471855006671 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 471855006672 dimer interface [polypeptide binding]; other site 471855006673 [2Fe-2S] cluster binding site [ion binding]; other site 471855006674 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 471855006675 SLBB domain; Region: SLBB; pfam10531 471855006676 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 471855006677 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855006678 4Fe-4S binding domain; Region: Fer4; pfam00037 471855006679 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471855006680 catalytic loop [active] 471855006681 iron binding site [ion binding]; other site 471855006682 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 471855006683 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 471855006684 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471855006685 ATP binding site [chemical binding]; other site 471855006686 substrate interface [chemical binding]; other site 471855006687 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471855006688 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471855006689 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471855006690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471855006691 ABC-ATPase subunit interface; other site 471855006692 dimer interface [polypeptide binding]; other site 471855006693 putative PBP binding regions; other site 471855006694 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 471855006695 putative ligand binding residues [chemical binding]; other site 471855006696 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471855006697 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471855006698 FMN binding site [chemical binding]; other site 471855006699 dimer interface [polypeptide binding]; other site 471855006700 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 471855006701 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 471855006702 Rubredoxin; Region: Rubredoxin; pfam00301 471855006703 iron binding site [ion binding]; other site 471855006704 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855006705 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855006706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855006709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855006710 dimerization interface [polypeptide binding]; other site 471855006711 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 471855006712 heme-binding site [chemical binding]; other site 471855006713 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 471855006714 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 471855006715 active site 471855006716 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 471855006717 active site 471855006718 N-terminal domain interface [polypeptide binding]; other site 471855006719 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471855006720 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471855006721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471855006722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006723 Walker A/P-loop; other site 471855006724 ATP binding site [chemical binding]; other site 471855006725 Q-loop/lid; other site 471855006726 ABC transporter signature motif; other site 471855006727 Walker B; other site 471855006728 D-loop; other site 471855006729 H-loop/switch region; other site 471855006730 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 471855006731 active site 471855006732 SAM binding site [chemical binding]; other site 471855006733 homodimer interface [polypeptide binding]; other site 471855006734 EamA-like transporter family; Region: EamA; pfam00892 471855006735 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855006736 EamA-like transporter family; Region: EamA; pfam00892 471855006737 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 471855006738 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471855006739 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 471855006740 NodB motif; other site 471855006741 active site 471855006742 catalytic site [active] 471855006743 Zn binding site [ion binding]; other site 471855006744 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471855006745 homodecamer interface [polypeptide binding]; other site 471855006746 GTP cyclohydrolase I; Provisional; Region: PLN03044 471855006747 active site 471855006748 putative catalytic site residues [active] 471855006749 zinc binding site [ion binding]; other site 471855006750 GTP-CH-I/GFRP interaction surface; other site 471855006751 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471855006752 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 471855006753 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471855006754 homodimer interface [polypeptide binding]; other site 471855006755 NADP binding site [chemical binding]; other site 471855006756 substrate binding site [chemical binding]; other site 471855006757 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 471855006758 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 471855006759 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 471855006760 Potassium binding sites [ion binding]; other site 471855006761 Cesium cation binding sites [ion binding]; other site 471855006762 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 471855006763 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471855006764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855006765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855006766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855006767 dimerization interface [polypeptide binding]; other site 471855006768 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 471855006769 metal binding site [ion binding]; metal-binding site 471855006770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 471855006771 classical (c) SDRs; Region: SDR_c; cd05233 471855006772 NAD(P) binding site [chemical binding]; other site 471855006773 active site 471855006774 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006776 DNA binding residues [nucleotide binding] 471855006777 dimerization interface [polypeptide binding]; other site 471855006778 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 471855006779 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471855006780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855006781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855006782 DNA binding residues [nucleotide binding] 471855006783 dimerization interface [polypeptide binding]; other site 471855006784 L-aspartate oxidase; Provisional; Region: PRK06175 471855006785 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 471855006786 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855006787 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471855006788 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 471855006789 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471855006790 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471855006791 metal binding site 2 [ion binding]; metal-binding site 471855006792 putative DNA binding helix; other site 471855006793 metal binding site 1 [ion binding]; metal-binding site 471855006794 dimer interface [polypeptide binding]; other site 471855006795 structural Zn2+ binding site [ion binding]; other site 471855006796 peroxiredoxin; Region: AhpC; TIGR03137 471855006797 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 471855006798 dimer interface [polypeptide binding]; other site 471855006799 decamer (pentamer of dimers) interface [polypeptide binding]; other site 471855006800 catalytic triad [active] 471855006801 peroxidatic and resolving cysteines [active] 471855006802 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 471855006803 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855006804 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 471855006805 catalytic residue [active] 471855006806 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471855006807 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 471855006808 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 471855006809 CPxP motif; other site 471855006810 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 471855006811 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471855006812 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471855006813 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 471855006814 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 471855006815 propionate/acetate kinase; Provisional; Region: PRK12379 471855006816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006818 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 471855006819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855006820 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 471855006821 active site 471855006822 glycine/sarcosine/betaine reductase complex protein A; Reviewed; Region: PRK13265 471855006823 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471855006824 catalytic residues [active] 471855006825 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471855006826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855006827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471855006828 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 471855006829 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 471855006830 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 471855006831 Uncharacterized membrane protein [Function unknown]; Region: COG3949 471855006832 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471855006833 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471855006834 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 471855006835 catalytic loop [active] 471855006836 iron binding site [ion binding]; other site 471855006837 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471855006838 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 471855006839 [4Fe-4S] binding site [ion binding]; other site 471855006840 molybdopterin cofactor binding site; other site 471855006841 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 471855006842 molybdopterin cofactor binding site; other site 471855006843 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 471855006844 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 471855006845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855006846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471855006847 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 471855006848 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 471855006849 G1 box; other site 471855006850 putative GEF interaction site [polypeptide binding]; other site 471855006851 GTP/Mg2+ binding site [chemical binding]; other site 471855006852 Switch I region; other site 471855006853 G2 box; other site 471855006854 G3 box; other site 471855006855 Switch II region; other site 471855006856 G4 box; other site 471855006857 G5 box; other site 471855006858 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 471855006859 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 471855006860 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 471855006861 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 471855006862 selenocysteine synthase; Provisional; Region: PRK04311 471855006863 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 471855006864 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 471855006865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855006866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855006867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471855006868 dimerization interface [polypeptide binding]; other site 471855006869 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 471855006870 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 471855006871 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 471855006872 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 471855006873 thiamine-monophosphate kinase; Region: thiL; TIGR01379 471855006874 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 471855006875 dimerization interface [polypeptide binding]; other site 471855006876 putative ATP binding site [chemical binding]; other site 471855006877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471855006878 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855006879 BCCT family transporter; Region: BCCT; pfam02028 471855006880 glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917 471855006881 selenoprotein B, glycine/betaine/sarcosine/D-proline reductase family; Region: various_sel_PB; TIGR01918 471855006882 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 471855006883 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471855006884 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 471855006885 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471855006886 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471855006887 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855006888 catalytic residue [active] 471855006889 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 471855006890 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 471855006891 CPxP motif; other site 471855006892 DsrE/DsrF-like family; Region: DrsE; pfam02635 471855006893 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 471855006894 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 471855006895 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 471855006896 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 471855006897 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 471855006898 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 471855006899 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855006900 putative active site [active] 471855006901 putative metal binding site [ion binding]; other site 471855006902 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 471855006903 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 471855006904 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 471855006905 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855006906 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855006907 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 471855006908 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 471855006909 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855006910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855006911 FeS/SAM binding site; other site 471855006912 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 471855006913 nudix motif; other site 471855006914 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 471855006915 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471855006916 active site 471855006917 NAD binding site [chemical binding]; other site 471855006918 metal binding site [ion binding]; metal-binding site 471855006919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855006920 Coenzyme A binding pocket [chemical binding]; other site 471855006921 Sterol carrier protein domain; Region: SCP2_2; pfam13530 471855006922 Predicted transcriptional regulators [Transcription]; Region: COG1733 471855006923 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471855006924 Predicted transcriptional regulators [Transcription]; Region: COG1733 471855006925 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471855006926 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 471855006927 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 471855006928 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 471855006929 acyl-activating enzyme (AAE) consensus motif; other site 471855006930 AMP binding site [chemical binding]; other site 471855006931 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471855006932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471855006933 Coenzyme A binding pocket [chemical binding]; other site 471855006934 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855006935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855006936 non-specific DNA binding site [nucleotide binding]; other site 471855006937 salt bridge; other site 471855006938 sequence-specific DNA binding site [nucleotide binding]; other site 471855006939 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 471855006940 glutaminase A; Region: Gln_ase; TIGR03814 471855006941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855006942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855006943 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855006944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855006945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006946 Walker A/P-loop; other site 471855006947 ATP binding site [chemical binding]; other site 471855006948 Q-loop/lid; other site 471855006949 ABC transporter signature motif; other site 471855006950 Walker B; other site 471855006951 D-loop; other site 471855006952 H-loop/switch region; other site 471855006953 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855006954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855006955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006956 Walker A/P-loop; other site 471855006957 ATP binding site [chemical binding]; other site 471855006958 Q-loop/lid; other site 471855006959 ABC transporter signature motif; other site 471855006960 Walker B; other site 471855006961 D-loop; other site 471855006962 H-loop/switch region; other site 471855006963 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 471855006964 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 471855006965 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471855006966 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 471855006967 Walker A/P-loop; other site 471855006968 ATP binding site [chemical binding]; other site 471855006969 Q-loop/lid; other site 471855006970 ABC transporter signature motif; other site 471855006971 Walker B; other site 471855006972 D-loop; other site 471855006973 H-loop/switch region; other site 471855006974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855006975 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471855006976 Walker A/P-loop; other site 471855006977 ATP binding site [chemical binding]; other site 471855006978 Q-loop/lid; other site 471855006979 ABC transporter signature motif; other site 471855006980 Walker B; other site 471855006981 D-loop; other site 471855006982 H-loop/switch region; other site 471855006983 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 471855006984 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471855006985 MgtE intracellular N domain; Region: MgtE_N; smart00924 471855006986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471855006987 Divalent cation transporter; Region: MgtE; pfam01769 471855006988 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 471855006989 FMN binding site [chemical binding]; other site 471855006990 substrate binding site [chemical binding]; other site 471855006991 putative catalytic residue [active] 471855006992 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471855006993 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 471855006994 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471855006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855006996 dimer interface [polypeptide binding]; other site 471855006997 conserved gate region; other site 471855006998 ABC-ATPase subunit interface; other site 471855006999 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471855007000 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471855007001 Walker A/P-loop; other site 471855007002 ATP binding site [chemical binding]; other site 471855007003 Q-loop/lid; other site 471855007004 ABC transporter signature motif; other site 471855007005 Walker B; other site 471855007006 D-loop; other site 471855007007 H-loop/switch region; other site 471855007008 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 471855007009 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 471855007010 B12 binding site [chemical binding]; other site 471855007011 cobalt ligand [ion binding]; other site 471855007012 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 471855007013 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 471855007014 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471855007015 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855007016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855007017 non-specific DNA binding site [nucleotide binding]; other site 471855007018 salt bridge; other site 471855007019 sequence-specific DNA binding site [nucleotide binding]; other site 471855007020 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 471855007021 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 471855007022 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 471855007023 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855007024 non-specific DNA binding site [nucleotide binding]; other site 471855007025 salt bridge; other site 471855007026 sequence-specific DNA binding site [nucleotide binding]; other site 471855007027 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471855007028 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 471855007029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471855007030 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 471855007031 TfoX N-terminal domain; Region: TfoX_N; pfam04993 471855007032 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471855007033 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471855007034 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 471855007035 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 471855007036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007037 G protein alpha subunit; Region: G_alpha; smart00275 471855007038 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 471855007039 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 471855007040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471855007041 S-adenosylmethionine binding site [chemical binding]; other site 471855007042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471855007043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855007044 non-specific DNA binding site [nucleotide binding]; other site 471855007045 salt bridge; other site 471855007046 sequence-specific DNA binding site [nucleotide binding]; other site 471855007047 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 471855007048 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 471855007049 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 471855007050 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471855007051 NAD binding site [chemical binding]; other site 471855007052 substrate binding site [chemical binding]; other site 471855007053 putative active site [active] 471855007054 Predicted transcriptional regulator [Transcription]; Region: COG1959 471855007055 Transcriptional regulator; Region: Rrf2; pfam02082 471855007056 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 471855007057 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 471855007058 Short C-terminal domain; Region: SHOCT; pfam09851 471855007059 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 471855007060 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855007061 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855007062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855007063 Walker A/P-loop; other site 471855007064 ATP binding site [chemical binding]; other site 471855007065 Q-loop/lid; other site 471855007066 ABC transporter signature motif; other site 471855007067 Walker B; other site 471855007068 D-loop; other site 471855007069 H-loop/switch region; other site 471855007070 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471855007071 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 471855007072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855007073 Walker A/P-loop; other site 471855007074 ATP binding site [chemical binding]; other site 471855007075 Q-loop/lid; other site 471855007076 ABC transporter signature motif; other site 471855007077 Walker B; other site 471855007078 D-loop; other site 471855007079 H-loop/switch region; other site 471855007080 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 471855007081 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 471855007082 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 471855007083 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 471855007084 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471855007085 catalytic loop [active] 471855007086 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 471855007087 iron binding site [ion binding]; other site 471855007088 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 471855007089 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 471855007090 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 471855007091 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 471855007092 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 471855007093 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855007094 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471855007095 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471855007096 Walker A/P-loop; other site 471855007097 ATP binding site [chemical binding]; other site 471855007098 Q-loop/lid; other site 471855007099 ABC transporter signature motif; other site 471855007100 Walker B; other site 471855007101 D-loop; other site 471855007102 H-loop/switch region; other site 471855007103 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471855007104 FtsX-like permease family; Region: FtsX; pfam02687 471855007105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855007106 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471855007107 dimer interface [polypeptide binding]; other site 471855007108 ADP-ribose binding site [chemical binding]; other site 471855007109 active site 471855007110 nudix motif; other site 471855007111 metal binding site [ion binding]; metal-binding site 471855007112 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471855007113 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471855007114 seryl-tRNA synthetase; Provisional; Region: PRK05431 471855007115 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471855007116 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471855007117 dimer interface [polypeptide binding]; other site 471855007118 active site 471855007119 motif 1; other site 471855007120 motif 2; other site 471855007121 motif 3; other site 471855007122 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 471855007123 dimer interface [polypeptide binding]; other site 471855007124 pyridoxal binding site [chemical binding]; other site 471855007125 ATP binding site [chemical binding]; other site 471855007126 EamA-like transporter family; Region: EamA; pfam00892 471855007127 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855007128 EamA-like transporter family; Region: EamA; pfam00892 471855007129 homoserine dehydrogenase; Provisional; Region: PRK06349 471855007130 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471855007131 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471855007132 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855007133 Double zinc ribbon; Region: DZR; pfam12773 471855007134 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 471855007135 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471855007136 TrkA-N domain; Region: TrkA_N; pfam02254 471855007137 TrkA-C domain; Region: TrkA_C; pfam02080 471855007138 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 471855007139 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 471855007140 transmembrane helices; other site 471855007141 Rrf2 family protein; Region: rrf2_super; TIGR00738 471855007142 Transcriptional regulator; Region: Rrf2; pfam02082 471855007143 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 471855007144 FMN binding site [chemical binding]; other site 471855007145 dimer interface [polypeptide binding]; other site 471855007146 CpXC protein; Region: CpXC; pfam14353 471855007147 Protein required for attachment to host cells; Region: Host_attach; cl02398 471855007148 FAD binding domain; Region: FAD_binding_2; pfam00890 471855007149 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855007150 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 471855007151 Helix-turn-helix domain; Region: HTH_17; pfam12728 471855007152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471855007153 non-specific DNA binding site [nucleotide binding]; other site 471855007154 salt bridge; other site 471855007155 sequence-specific DNA binding site [nucleotide binding]; other site 471855007156 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471855007157 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 471855007158 Int/Topo IB signature motif; other site 471855007159 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471855007160 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 471855007161 Cation efflux family; Region: Cation_efflux; pfam01545 471855007162 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 471855007163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 471855007164 active site 471855007165 argininosuccinate lyase; Provisional; Region: PRK00855 471855007166 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471855007167 active sites [active] 471855007168 tetramer interface [polypeptide binding]; other site 471855007169 argininosuccinate synthase; Provisional; Region: PRK13820 471855007170 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471855007171 ANP binding site [chemical binding]; other site 471855007172 Substrate Binding Site II [chemical binding]; other site 471855007173 Substrate Binding Site I [chemical binding]; other site 471855007174 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 471855007175 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471855007176 dimer interface [polypeptide binding]; other site 471855007177 putative functional site; other site 471855007178 putative MPT binding site; other site 471855007179 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 471855007180 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 471855007181 active site 471855007182 FMN binding site [chemical binding]; other site 471855007183 substrate binding site [chemical binding]; other site 471855007184 putative catalytic residue [active] 471855007185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471855007186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855007187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855007188 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855007189 dimerization interface [polypeptide binding]; other site 471855007190 hypothetical protein; Provisional; Region: PRK10621 471855007191 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471855007192 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471855007193 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471855007194 nucleotide binding pocket [chemical binding]; other site 471855007195 K-X-D-G motif; other site 471855007196 catalytic site [active] 471855007197 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471855007198 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471855007199 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471855007200 Dimer interface [polypeptide binding]; other site 471855007201 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471855007202 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471855007203 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471855007204 glutaminase active site [active] 471855007205 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471855007206 dimer interface [polypeptide binding]; other site 471855007207 active site 471855007208 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471855007209 dimer interface [polypeptide binding]; other site 471855007210 active site 471855007211 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 471855007212 Sel1-like repeats; Region: SEL1; smart00671 471855007213 Sel1-like repeats; Region: SEL1; smart00671 471855007214 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 471855007215 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 471855007216 HSP70 interaction site [polypeptide binding]; other site 471855007217 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 471855007218 Predicted membrane protein [Function unknown]; Region: COG1511 471855007219 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 471855007220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855007221 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471855007222 Walker A/P-loop; other site 471855007223 ATP binding site [chemical binding]; other site 471855007224 Q-loop/lid; other site 471855007225 ABC transporter signature motif; other site 471855007226 Walker B; other site 471855007227 D-loop; other site 471855007228 H-loop/switch region; other site 471855007229 Transcriptional regulator; Region: Rrf2; cl17282 471855007230 Rrf2 family protein; Region: rrf2_super; TIGR00738 471855007231 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855007232 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 471855007233 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471855007234 Walker A/P-loop; other site 471855007235 ATP binding site [chemical binding]; other site 471855007236 Q-loop/lid; other site 471855007237 ABC transporter signature motif; other site 471855007238 Walker B; other site 471855007239 D-loop; other site 471855007240 H-loop/switch region; other site 471855007241 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471855007242 FeS assembly protein SufB; Region: sufB; TIGR01980 471855007243 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471855007244 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 471855007245 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471855007246 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471855007247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855007248 catalytic residue [active] 471855007249 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471855007250 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471855007251 trimerization site [polypeptide binding]; other site 471855007252 active site 471855007253 PIN domain; Region: PIN_3; pfam13470 471855007254 NAD-dependent deacetylase; Provisional; Region: PRK00481 471855007255 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 471855007256 NAD+ binding site [chemical binding]; other site 471855007257 substrate binding site [chemical binding]; other site 471855007258 Zn binding site [ion binding]; other site 471855007259 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471855007260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855007261 FeS/SAM binding site; other site 471855007262 Protein of unknown function DUF111; Region: DUF111; cl03398 471855007263 Protein of unknown function DUF111; Region: DUF111; pfam01969 471855007264 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 471855007265 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 471855007266 AIR carboxylase; Region: AIRC; smart01001 471855007267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855007268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855007269 DNA binding residues [nucleotide binding] 471855007270 dimerization interface [polypeptide binding]; other site 471855007271 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 471855007272 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 471855007273 Cysteine-rich domain; Region: CCG; pfam02754 471855007274 Cysteine-rich domain; Region: CCG; pfam02754 471855007275 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 471855007276 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471855007277 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855007278 L-aspartate oxidase; Provisional; Region: PRK06175 471855007279 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 471855007280 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471855007281 Fumarase C-terminus; Region: Fumerase_C; cl00795 471855007282 fumarate hydratase; Provisional; Region: PRK06246 471855007283 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471855007284 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 471855007285 transmembrane helices; other site 471855007286 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471855007287 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 471855007288 transmembrane helices; other site 471855007289 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 471855007290 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471855007291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855007292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855007293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855007294 Ferrochelatase; Region: Ferrochelatase; pfam00762 471855007295 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471855007296 C-terminal domain interface [polypeptide binding]; other site 471855007297 active site 471855007298 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471855007299 active site 471855007300 N-terminal domain interface [polypeptide binding]; other site 471855007301 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471855007302 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855007303 active site 471855007304 ATP binding site [chemical binding]; other site 471855007305 substrate binding site [chemical binding]; other site 471855007306 activation loop (A-loop); other site 471855007307 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471855007308 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471855007309 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471855007310 phosphopeptide binding site; other site 471855007311 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471855007312 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471855007313 phosphopeptide binding site; other site 471855007314 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471855007315 Protein phosphatase 2C; Region: PP2C; pfam00481 471855007316 active site 471855007317 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471855007318 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471855007319 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471855007320 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471855007321 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471855007322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471855007323 active site 471855007324 ATP binding site [chemical binding]; other site 471855007325 substrate binding site [chemical binding]; other site 471855007326 activation loop (A-loop); other site 471855007327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 471855007328 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471855007329 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471855007330 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471855007331 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471855007332 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 471855007333 EamA-like transporter family; Region: EamA; pfam00892 471855007334 EamA-like transporter family; Region: EamA; pfam00892 471855007335 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 471855007336 homooctamer interface [polypeptide binding]; other site 471855007337 active site 471855007338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855007339 Zn2+ binding site [ion binding]; other site 471855007340 Mg2+ binding site [ion binding]; other site 471855007341 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 471855007342 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855007343 Tic20-like protein; Region: Tic20; pfam09685 471855007344 PBP superfamily domain; Region: PBP_like_2; pfam12849 471855007345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855007346 dimer interface [polypeptide binding]; other site 471855007347 conserved gate region; other site 471855007348 putative PBP binding loops; other site 471855007349 ABC-ATPase subunit interface; other site 471855007350 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471855007351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855007352 Walker A/P-loop; other site 471855007353 ATP binding site [chemical binding]; other site 471855007354 Q-loop/lid; other site 471855007355 ABC transporter signature motif; other site 471855007356 Walker B; other site 471855007357 D-loop; other site 471855007358 H-loop/switch region; other site 471855007359 aspartate aminotransferase; Provisional; Region: PRK06836 471855007360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855007361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855007362 homodimer interface [polypeptide binding]; other site 471855007363 catalytic residue [active] 471855007364 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471855007365 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471855007366 Walker A/P-loop; other site 471855007367 ATP binding site [chemical binding]; other site 471855007368 Q-loop/lid; other site 471855007369 ABC transporter signature motif; other site 471855007370 Walker B; other site 471855007371 D-loop; other site 471855007372 H-loop/switch region; other site 471855007373 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471855007374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 471855007375 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471855007376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855007377 dimer interface [polypeptide binding]; other site 471855007378 conserved gate region; other site 471855007379 putative PBP binding loops; other site 471855007380 ABC-ATPase subunit interface; other site 471855007381 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 471855007382 putative active site [active] 471855007383 metal binding site [ion binding]; metal-binding site 471855007384 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471855007385 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471855007386 homodimer interface [polypeptide binding]; other site 471855007387 substrate-cofactor binding pocket; other site 471855007388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855007389 catalytic residue [active] 471855007390 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855007391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855007392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 471855007393 dimerization interface [polypeptide binding]; other site 471855007394 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 471855007395 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471855007396 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855007397 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007398 molybdopterin cofactor binding site; other site 471855007399 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855007400 molybdopterin cofactor binding site; other site 471855007401 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855007402 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855007403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471855007404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471855007405 FOG: CBS domain [General function prediction only]; Region: COG0517 471855007406 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 471855007407 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471855007408 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471855007409 Walker A/P-loop; other site 471855007410 ATP binding site [chemical binding]; other site 471855007411 Q-loop/lid; other site 471855007412 ABC transporter signature motif; other site 471855007413 Walker B; other site 471855007414 D-loop; other site 471855007415 H-loop/switch region; other site 471855007416 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471855007417 FtsX-like permease family; Region: FtsX; pfam02687 471855007418 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855007419 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855007420 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855007421 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007422 molybdopterin cofactor binding site; other site 471855007423 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855007424 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007425 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007426 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 471855007427 putative molybdopterin cofactor binding site; other site 471855007428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471855007429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471855007430 DNA binding residues [nucleotide binding] 471855007431 dimerization interface [polypeptide binding]; other site 471855007432 Transcriptional regulator [Transcription]; Region: LysR; COG0583 471855007433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471855007434 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 471855007435 putative DNA binding helix; other site 471855007436 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 471855007437 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 471855007438 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 471855007439 4Fe-4S binding domain; Region: Fer4_5; pfam12801 471855007440 Ferredoxin [Energy production and conversion]; Region: COG1146 471855007441 Ferredoxin [Energy production and conversion]; Region: COG1146 471855007442 4Fe-4S binding domain; Region: Fer4; pfam00037 471855007443 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 471855007444 Ferredoxin [Energy production and conversion]; Region: COG1146 471855007445 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855007446 UDP-glucose 4-epimerase; Region: PLN02240 471855007447 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 471855007448 NAD binding site [chemical binding]; other site 471855007449 homodimer interface [polypeptide binding]; other site 471855007450 active site 471855007451 substrate binding site [chemical binding]; other site 471855007452 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 471855007453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471855007454 Zn2+ binding site [ion binding]; other site 471855007455 Mg2+ binding site [ion binding]; other site 471855007456 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471855007457 EamA-like transporter family; Region: EamA; cl17759 471855007458 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471855007459 EamA-like transporter family; Region: EamA; pfam00892 471855007460 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 471855007461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471855007462 acyl-activating enzyme (AAE) consensus motif; other site 471855007463 AMP binding site [chemical binding]; other site 471855007464 active site 471855007465 CoA binding site [chemical binding]; other site 471855007466 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 471855007467 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 471855007468 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 471855007469 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 471855007470 dimer interface [polypeptide binding]; other site 471855007471 PYR/PP interface [polypeptide binding]; other site 471855007472 TPP binding site [chemical binding]; other site 471855007473 substrate binding site [chemical binding]; other site 471855007474 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 471855007475 TPP-binding site; other site 471855007476 4Fe-4S binding domain; Region: Fer4; pfam00037 471855007477 AIR carboxylase; Region: AIRC; pfam00731 471855007478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471855007479 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855007480 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471855007481 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471855007482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 471855007483 Transposase; Region: DEDD_Tnp_IS110; pfam01548 471855007484 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471855007485 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471855007486 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007487 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 471855007488 molybdopterin cofactor binding site; other site 471855007489 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855007490 molybdopterin cofactor binding site; other site 471855007491 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855007492 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471855007493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855007494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471855007496 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007497 molybdopterin cofactor binding site; other site 471855007498 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855007499 molybdopterin cofactor binding site; other site 471855007500 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 471855007501 4Fe-4S binding domain; Region: Fer4; cl02805 471855007502 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 471855007503 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 471855007504 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855007505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007506 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471855007507 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 471855007508 molybdopterin cofactor binding site; other site 471855007509 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 471855007510 molybdopterin cofactor binding site; other site 471855007511 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 471855007512 4Fe-4S binding domain; Region: Fer4; pfam00037 471855007513 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 471855007514 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 471855007515 AAA domain; Region: AAA_14; pfam13173 471855007516 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471855007517 oxidoreductase; Provisional; Region: PRK10015 471855007518 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 471855007519 coproporphyrinogen III oxidase; Provisional; Region: PRK08629 471855007520 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855007521 FeS/SAM binding site; other site 471855007522 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471855007523 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471855007524 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471855007525 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471855007526 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471855007527 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471855007528 GDP-binding site [chemical binding]; other site 471855007529 ACT binding site; other site 471855007530 IMP binding site; other site 471855007531 AAA domain; Region: AAA_23; pfam13476 471855007532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471855007533 ABC transporter signature motif; other site 471855007534 Walker B; other site 471855007535 D-loop; other site 471855007536 H-loop/switch region; other site 471855007537 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 471855007538 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471855007539 active site 471855007540 metal binding site [ion binding]; metal-binding site 471855007541 DNA binding site [nucleotide binding] 471855007542 replicative DNA helicase; Region: DnaB; TIGR00665 471855007543 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471855007544 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471855007545 Walker A motif; other site 471855007546 ATP binding site [chemical binding]; other site 471855007547 Walker B motif; other site 471855007548 DNA binding loops [nucleotide binding] 471855007549 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471855007550 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471855007551 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471855007552 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471855007553 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471855007554 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471855007555 dimer interface [polypeptide binding]; other site 471855007556 ssDNA binding site [nucleotide binding]; other site 471855007557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471855007558 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471855007559 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 471855007560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855007561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007562 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 471855007563 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 471855007564 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471855007565 NlpC/P60 family; Region: NLPC_P60; pfam00877 471855007566 SurA N-terminal domain; Region: SurA_N_3; cl07813 471855007567 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 471855007568 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 471855007569 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471855007570 G1 box; other site 471855007571 putative GEF interaction site [polypeptide binding]; other site 471855007572 GTP/Mg2+ binding site [chemical binding]; other site 471855007573 Switch I region; other site 471855007574 G2 box; other site 471855007575 G3 box; other site 471855007576 Switch II region; other site 471855007577 G4 box; other site 471855007578 G5 box; other site 471855007579 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471855007580 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471855007581 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471855007582 HSP70 interaction site [polypeptide binding]; other site 471855007583 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 471855007584 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471855007585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855007586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 471855007588 LemA family; Region: LemA; cl00742 471855007589 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471855007590 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 471855007591 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471855007592 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 471855007593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 471855007594 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 471855007595 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 471855007596 Walker A/P-loop; other site 471855007597 ATP binding site [chemical binding]; other site 471855007598 Q-loop/lid; other site 471855007599 ABC transporter signature motif; other site 471855007600 Walker B; other site 471855007601 D-loop; other site 471855007602 H-loop/switch region; other site 471855007603 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 471855007604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855007605 dimer interface [polypeptide binding]; other site 471855007606 conserved gate region; other site 471855007607 putative PBP binding loops; other site 471855007608 ABC-ATPase subunit interface; other site 471855007609 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 471855007610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471855007611 dimer interface [polypeptide binding]; other site 471855007612 conserved gate region; other site 471855007613 putative PBP binding loops; other site 471855007614 ABC-ATPase subunit interface; other site 471855007615 PBP superfamily domain; Region: PBP_like_2; cl17296 471855007616 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471855007617 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 471855007618 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 471855007619 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 471855007620 active site 471855007621 trimer interface [polypeptide binding]; other site 471855007622 substrate binding site [chemical binding]; other site 471855007623 CoA binding site [chemical binding]; other site 471855007624 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471855007625 putative CoA binding site [chemical binding]; other site 471855007626 putative trimer interface [polypeptide binding]; other site 471855007627 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471855007628 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471855007629 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471855007630 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471855007631 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471855007632 dimer interface [polypeptide binding]; other site 471855007633 active site 471855007634 catalytic residue [active] 471855007635 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 471855007636 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 471855007637 active site 471855007638 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471855007639 substrate binding site [chemical binding]; other site 471855007640 catalytic residues [active] 471855007641 dimer interface [polypeptide binding]; other site 471855007642 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471855007643 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 471855007644 metal binding site [ion binding]; metal-binding site 471855007645 dimer interface [polypeptide binding]; other site 471855007646 aspartate aminotransferase; Provisional; Region: PRK05764 471855007647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471855007648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471855007649 homodimer interface [polypeptide binding]; other site 471855007650 catalytic residue [active] 471855007651 citrate synthase; Provisional; Region: PRK14032 471855007652 Citrate synthase; Region: Citrate_synt; pfam00285 471855007653 oxalacetate binding site [chemical binding]; other site 471855007654 citrylCoA binding site [chemical binding]; other site 471855007655 coenzyme A binding site [chemical binding]; other site 471855007656 catalytic triad [active] 471855007657 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 471855007658 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 471855007659 putative ligand binding site [chemical binding]; other site 471855007660 putative NAD binding site [chemical binding]; other site 471855007661 putative catalytic site [active] 471855007662 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 471855007663 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471855007664 catalytic residue [active] 471855007665 hybrid cluster protein; Provisional; Region: PRK05290 471855007666 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855007667 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 471855007668 ACS interaction site; other site 471855007669 CODH interaction site; other site 471855007670 metal cluster binding site [ion binding]; other site 471855007671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471855007672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471855007673 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 471855007674 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 471855007675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471855007676 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 471855007677 Walker A/P-loop; other site 471855007678 ATP binding site [chemical binding]; other site 471855007679 Q-loop/lid; other site 471855007680 ABC transporter signature motif; other site 471855007681 Walker B; other site 471855007682 D-loop; other site 471855007683 H-loop/switch region; other site 471855007684 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 471855007685 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 471855007686 AAA-like domain; Region: AAA_10; pfam12846 471855007687 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471855007688 Walker A motif; other site 471855007689 ATP binding site [chemical binding]; other site 471855007690 Walker B motif; other site 471855007691 Clp protease; Region: CLP_protease; pfam00574 471855007692 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471855007693 oligomer interface [polypeptide binding]; other site 471855007694 active site residues [active] 471855007695 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 471855007696 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 471855007697 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471855007698 active site 471855007699 catalytic site [active] 471855007700 substrate binding site [chemical binding]; other site 471855007701 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 471855007702 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471855007703 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471855007704 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 471855007705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471855007706 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 471855007707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471855007708 FeS/SAM binding site; other site 471855007709 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471855007710 ParB-like nuclease domain; Region: ParB; smart00470 471855007711 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471855007712 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471855007713 P-loop; other site 471855007714 Magnesium ion binding site [ion binding]; other site 471855007715 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 471855007716 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 471855007717 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 471855007718 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471855007719 G-X-X-G motif; other site 471855007720 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471855007721 RxxxH motif; other site 471855007722 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 471855007723 Haemolytic domain; Region: Haemolytic; pfam01809 471855007724 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 471855007725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471855007726 ATP binding site [chemical binding]; other site 471855007727 Mg2+ binding site [ion binding]; other site 471855007728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471855007729 G-X-G motif; other site 471855007730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471855007731 putative DNA binding site [nucleotide binding]; other site 471855007732 putative Zn2+ binding site [ion binding]; other site