-- dump date 20140620_071245 -- class Genbank::misc_feature -- table misc_feature_note -- id note 448385000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 448385000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 448385000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000004 Walker A motif; other site 448385000005 ATP binding site [chemical binding]; other site 448385000006 Walker B motif; other site 448385000007 arginine finger; other site 448385000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 448385000009 DnaA box-binding interface [nucleotide binding]; other site 448385000010 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385000011 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000012 active site 448385000013 ATP binding site [chemical binding]; other site 448385000014 substrate binding site [chemical binding]; other site 448385000015 activation loop (A-loop); other site 448385000016 AAA ATPase domain; Region: AAA_16; pfam13191 448385000017 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385000018 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 448385000019 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 448385000020 nucleotide binding site [chemical binding]; other site 448385000021 NEF interaction site [polypeptide binding]; other site 448385000022 SBD interface [polypeptide binding]; other site 448385000023 GrpE; Region: GrpE; pfam01025 448385000024 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 448385000025 dimer interface [polypeptide binding]; other site 448385000026 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 448385000027 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385000028 acetylornithine aminotransferase; Provisional; Region: PRK02627 448385000029 inhibitor-cofactor binding pocket; inhibition site 448385000030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385000031 catalytic residue [active] 448385000032 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385000033 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 448385000034 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 448385000035 metal binding site 2 [ion binding]; metal-binding site 448385000036 putative DNA binding helix; other site 448385000037 metal binding site 1 [ion binding]; metal-binding site 448385000038 dimer interface [polypeptide binding]; other site 448385000039 structural Zn2+ binding site [ion binding]; other site 448385000040 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 448385000041 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 448385000042 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 448385000043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385000044 RNA binding surface [nucleotide binding]; other site 448385000045 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385000046 active site 448385000047 Response regulator receiver domain; Region: Response_reg; pfam00072 448385000048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385000049 active site 448385000050 phosphorylation site [posttranslational modification] 448385000051 intermolecular recognition site; other site 448385000052 dimerization interface [polypeptide binding]; other site 448385000053 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 448385000054 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 448385000055 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 448385000056 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 448385000057 active site 448385000058 SAM binding site [chemical binding]; other site 448385000059 homodimer interface [polypeptide binding]; other site 448385000060 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 448385000061 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 448385000062 active site 448385000063 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385000064 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 448385000065 dimer interface [polypeptide binding]; other site 448385000066 active site 448385000067 Schiff base residues; other site 448385000068 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385000069 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385000070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385000071 Walker A/P-loop; other site 448385000072 ATP binding site [chemical binding]; other site 448385000073 Q-loop/lid; other site 448385000074 ABC transporter signature motif; other site 448385000075 Walker B; other site 448385000076 D-loop; other site 448385000077 H-loop/switch region; other site 448385000078 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385000079 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385000080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385000081 Walker A/P-loop; other site 448385000082 ATP binding site [chemical binding]; other site 448385000083 Q-loop/lid; other site 448385000084 ABC transporter signature motif; other site 448385000085 Walker B; other site 448385000086 D-loop; other site 448385000087 H-loop/switch region; other site 448385000088 Probable zinc-binding domain; Region: zf-trcl; pfam13451 448385000089 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 448385000090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000092 active site 448385000093 ATP binding site [chemical binding]; other site 448385000094 substrate binding site [chemical binding]; other site 448385000095 activation loop (A-loop); other site 448385000096 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 448385000097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 448385000098 active site 448385000099 motif I; other site 448385000100 motif II; other site 448385000101 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 448385000102 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 448385000103 putative RNA binding site [nucleotide binding]; other site 448385000104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385000105 S-adenosylmethionine binding site [chemical binding]; other site 448385000106 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 448385000107 putative active site [active] 448385000108 catalytic triad [active] 448385000109 putative dimer interface [polypeptide binding]; other site 448385000110 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 448385000111 IHF - DNA interface [nucleotide binding]; other site 448385000112 IHF dimer interface [polypeptide binding]; other site 448385000113 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 448385000114 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 448385000115 active site 448385000116 intersubunit interactions; other site 448385000117 catalytic residue [active] 448385000118 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 448385000119 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 448385000120 SEC-C motif; Region: SEC-C; pfam02810 448385000121 Response regulator receiver domain; Region: Response_reg; pfam00072 448385000122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 448385000123 active site 448385000124 phosphorylation site [posttranslational modification] 448385000125 intermolecular recognition site; other site 448385000126 dimerization interface [polypeptide binding]; other site 448385000127 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385000128 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 448385000129 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 448385000130 putative switch regulator; other site 448385000131 non-specific DNA interactions [nucleotide binding]; other site 448385000132 DNA binding site [nucleotide binding] 448385000133 sequence specific DNA binding site [nucleotide binding]; other site 448385000134 putative cAMP binding site [chemical binding]; other site 448385000135 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 448385000136 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 448385000137 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 448385000138 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 448385000139 6-phosphofructo-2-kinase; Region: 6PF2K; pfam01591 448385000140 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 448385000141 catalytic core [active] 448385000142 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 448385000143 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 448385000144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000145 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000146 active site 448385000147 ATP binding site [chemical binding]; other site 448385000148 substrate binding site [chemical binding]; other site 448385000149 activation loop (A-loop); other site 448385000150 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 448385000151 Transglycosylase; Region: Transgly; pfam00912 448385000152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 448385000153 TPR repeat; Region: TPR_11; pfam13414 448385000154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000155 binding surface 448385000156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000158 active site 448385000159 ATP binding site [chemical binding]; other site 448385000160 substrate binding site [chemical binding]; other site 448385000161 activation loop (A-loop); other site 448385000162 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 448385000163 active site 448385000164 Zn binding site [ion binding]; other site 448385000165 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 448385000166 agmatinase; Region: agmatinase; TIGR01230 448385000167 oligomer interface [polypeptide binding]; other site 448385000168 putative active site [active] 448385000169 Mn binding site [ion binding]; other site 448385000170 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385000171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385000172 putative acyl-acceptor binding pocket; other site 448385000173 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 448385000174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385000175 short chain dehydrogenase; Provisional; Region: PRK06139 448385000176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385000177 NAD(P) binding site [chemical binding]; other site 448385000178 active site 448385000179 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 448385000180 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385000181 substrate binding site [chemical binding]; other site 448385000182 oxyanion hole (OAH) forming residues; other site 448385000183 trimer interface [polypeptide binding]; other site 448385000184 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 448385000185 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 448385000186 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 448385000187 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 448385000188 dimer interface [polypeptide binding]; other site 448385000189 active site 448385000190 FOG: CBS domain [General function prediction only]; Region: COG0517 448385000191 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385000192 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 448385000193 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385000194 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385000195 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385000196 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385000197 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 448385000198 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385000199 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385000200 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 448385000201 generic binding surface I; other site 448385000202 generic binding surface II; other site 448385000203 Lamin Tail Domain; Region: LTD; pfam00932 448385000204 Beta-propeller repeat; Region: SBBP; pfam06739 448385000205 TPR repeat; Region: TPR_11; pfam13414 448385000206 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000208 active site 448385000209 ATP binding site [chemical binding]; other site 448385000210 substrate binding site [chemical binding]; other site 448385000211 activation loop (A-loop); other site 448385000212 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385000213 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 448385000214 ligand binding site [chemical binding]; other site 448385000215 flexible hinge region; other site 448385000216 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385000217 ligand binding site [chemical binding]; other site 448385000218 flexible hinge region; other site 448385000219 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 448385000220 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 448385000221 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385000222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385000223 homodimer interface [polypeptide binding]; other site 448385000224 catalytic residue [active] 448385000225 Cellulose binding domain; Region: CBM_3; smart01067 448385000226 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 448385000227 putative hydrophobic ligand binding site [chemical binding]; other site 448385000228 protein interface [polypeptide binding]; other site 448385000229 gate; other site 448385000230 hypothetical protein; Provisional; Region: PRK06184 448385000231 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385000232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385000233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385000234 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 448385000235 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 448385000236 dimerization interface [polypeptide binding]; other site 448385000237 domain crossover interface; other site 448385000238 redox-dependent activation switch; other site 448385000239 conserved repeat domain; Region: B_ant_repeat; TIGR01451 448385000240 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385000241 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385000242 ligand binding site [chemical binding]; other site 448385000243 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 448385000244 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 448385000245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385000246 Coenzyme A binding pocket [chemical binding]; other site 448385000247 acetylglutamate kinase; Provisional; Region: PRK04531 448385000248 AAK_NAGK-fArgBP: N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal...; Region: AAK_NAGK-fArgBP; cd04252 448385000249 putative nucleotide binding site [chemical binding]; other site 448385000250 putative N-acetyl-L-glutamate binding site [chemical binding]; other site 448385000251 Protein of unknown function (DUF619); Region: DUF619; pfam04768 448385000252 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 448385000253 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 448385000254 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 448385000255 Family description; Region: UvrD_C_2; pfam13538 448385000256 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 448385000257 UbiA prenyltransferase family; Region: UbiA; pfam01040 448385000258 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 448385000259 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 448385000260 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 448385000261 active site 448385000262 catalytic site [active] 448385000263 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 448385000264 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 448385000265 substrate binding site [chemical binding]; other site 448385000266 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 448385000267 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 448385000268 substrate binding site [chemical binding]; other site 448385000269 ligand binding site [chemical binding]; other site 448385000270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385000271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385000272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385000273 dimerization interface [polypeptide binding]; other site 448385000274 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 448385000275 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 448385000276 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 448385000277 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 448385000278 active site 448385000279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385000280 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385000281 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 448385000282 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 448385000283 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 448385000284 dimerization interface [polypeptide binding]; other site 448385000285 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385000286 dinuclear metal binding motif [ion binding]; other site 448385000287 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 448385000288 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 448385000289 MOSC domain; Region: MOSC; pfam03473 448385000290 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 448385000291 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 448385000292 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385000293 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 448385000294 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 448385000295 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 448385000296 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385000297 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385000298 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 448385000299 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385000300 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385000301 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385000302 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385000303 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385000304 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385000305 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385000306 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385000307 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385000308 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385000309 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385000310 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385000311 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385000312 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385000313 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 448385000314 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385000315 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385000316 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385000317 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385000318 putative active site [active] 448385000319 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385000320 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385000321 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 448385000322 Amidase; Region: Amidase; cl11426 448385000323 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385000324 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 448385000325 PilZ domain; Region: PilZ; pfam07238 448385000326 conserved repeat domain; Region: B_ant_repeat; TIGR01451 448385000327 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385000328 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385000329 ligand binding site [chemical binding]; other site 448385000330 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385000331 Cytochrome P450; Region: p450; cl12078 448385000332 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385000333 Ligand Binding Site [chemical binding]; other site 448385000334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385000335 Ligand Binding Site [chemical binding]; other site 448385000336 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 448385000337 transmembrane helices; other site 448385000338 TrkA-C domain; Region: TrkA_C; pfam02080 448385000339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 448385000340 TrkA-C domain; Region: TrkA_C; pfam02080 448385000341 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 448385000342 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 448385000343 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 448385000344 inhibitor binding site; inhibition site 448385000345 active site 448385000346 Gram-negative bacterial tonB protein; Region: TonB; cl10048 448385000347 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 448385000348 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 448385000349 active site 448385000350 HIGH motif; other site 448385000351 KMSKS motif; other site 448385000352 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 448385000353 anticodon binding site; other site 448385000354 tRNA binding surface [nucleotide binding]; other site 448385000355 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 448385000356 dimer interface [polypeptide binding]; other site 448385000357 putative tRNA-binding site [nucleotide binding]; other site 448385000358 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385000359 RDD family; Region: RDD; pfam06271 448385000360 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385000361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385000362 FeS/SAM binding site; other site 448385000363 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 448385000364 phosphoinositide binding site [chemical binding]; other site 448385000365 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 448385000366 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 448385000367 putative NAD(P) binding site [chemical binding]; other site 448385000368 dimer interface [polypeptide binding]; other site 448385000369 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385000370 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 448385000371 Protein of unknown function (DUF692); Region: DUF692; cl01263 448385000372 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 448385000373 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385000374 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 448385000375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000377 active site 448385000378 ATP binding site [chemical binding]; other site 448385000379 substrate binding site [chemical binding]; other site 448385000380 activation loop (A-loop); other site 448385000381 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 448385000382 putative catalytic site [active] 448385000383 putative metal binding site [ion binding]; other site 448385000384 putative phosphate binding site [ion binding]; other site 448385000385 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 448385000386 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 448385000387 Poly(A) polymerase; Provisional; Region: PTZ00418 448385000388 active site 448385000389 metal binding triad [ion binding]; metal-binding site 448385000390 Thaumatin family; Region: Thaumatin; pfam00314 448385000391 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 448385000392 hypothetical protein; Provisional; Region: PRK07907 448385000393 metal binding site [ion binding]; metal-binding site 448385000394 putative dimer interface [polypeptide binding]; other site 448385000395 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 448385000396 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 448385000397 active site 448385000398 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385000399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385000400 YceI-like domain; Region: YceI; pfam04264 448385000401 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 448385000402 putative active site [active] 448385000403 metal binding site [ion binding]; metal-binding site 448385000404 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 448385000405 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385000406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385000407 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385000408 putative effector binding pocket; other site 448385000409 dimerization interface [polypeptide binding]; other site 448385000410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385000411 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 448385000412 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385000413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385000414 putative PBP binding loops; other site 448385000415 ABC-ATPase subunit interface; other site 448385000416 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385000417 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385000418 Walker A/P-loop; other site 448385000419 ATP binding site [chemical binding]; other site 448385000420 Q-loop/lid; other site 448385000421 ABC transporter signature motif; other site 448385000422 Walker B; other site 448385000423 D-loop; other site 448385000424 H-loop/switch region; other site 448385000425 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 448385000426 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 448385000427 active site 448385000428 non-prolyl cis peptide bond; other site 448385000429 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 448385000430 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 448385000431 protein binding site [polypeptide binding]; other site 448385000432 C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561 448385000433 Catalytic dyad [active] 448385000434 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 448385000435 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 448385000436 dimer interface [polypeptide binding]; other site 448385000437 decamer (pentamer of dimers) interface [polypeptide binding]; other site 448385000438 catalytic triad [active] 448385000439 Cupin domain; Region: Cupin_2; cl17218 448385000440 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 448385000441 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385000442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 448385000443 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 448385000444 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 448385000445 homodimer interface [polypeptide binding]; other site 448385000446 substrate-cofactor binding pocket; other site 448385000447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385000448 catalytic residue [active] 448385000449 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 448385000450 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385000451 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385000452 substrate binding pocket [chemical binding]; other site 448385000453 dimerization interface [polypeptide binding]; other site 448385000454 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385000455 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385000456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385000457 Walker A/P-loop; other site 448385000458 ATP binding site [chemical binding]; other site 448385000459 Q-loop/lid; other site 448385000460 ABC transporter signature motif; other site 448385000461 Walker B; other site 448385000462 D-loop; other site 448385000463 H-loop/switch region; other site 448385000464 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 448385000465 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385000466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385000467 Walker A/P-loop; other site 448385000468 ATP binding site [chemical binding]; other site 448385000469 Q-loop/lid; other site 448385000470 ABC transporter signature motif; other site 448385000471 Walker B; other site 448385000472 D-loop; other site 448385000473 H-loop/switch region; other site 448385000474 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 448385000475 PAS domain S-box; Region: sensory_box; TIGR00229 448385000476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385000477 putative active site [active] 448385000478 heme pocket [chemical binding]; other site 448385000479 PAS domain S-box; Region: sensory_box; TIGR00229 448385000480 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385000481 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 448385000482 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385000483 C-terminal domain interface [polypeptide binding]; other site 448385000484 GSH binding site (G-site) [chemical binding]; other site 448385000485 dimer interface [polypeptide binding]; other site 448385000486 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000487 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000488 active site 448385000489 ATP binding site [chemical binding]; other site 448385000490 substrate binding site [chemical binding]; other site 448385000491 activation loop (A-loop); other site 448385000492 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385000493 cyclase homology domain; Region: CHD; cd07302 448385000494 nucleotidyl binding site; other site 448385000495 metal binding site [ion binding]; metal-binding site 448385000496 dimer interface [polypeptide binding]; other site 448385000497 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385000498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385000499 PAS fold; Region: PAS_3; pfam08447 448385000500 putative active site [active] 448385000501 heme pocket [chemical binding]; other site 448385000502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385000503 PAS fold; Region: PAS_3; pfam08447 448385000504 putative active site [active] 448385000505 heme pocket [chemical binding]; other site 448385000506 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385000507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385000508 putative active site [active] 448385000509 heme pocket [chemical binding]; other site 448385000510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385000511 dimer interface [polypeptide binding]; other site 448385000512 phosphorylation site [posttranslational modification] 448385000513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385000514 ATP binding site [chemical binding]; other site 448385000515 Mg2+ binding site [ion binding]; other site 448385000516 G-X-G motif; other site 448385000517 Transposase IS200 like; Region: Y1_Tnp; cl00848 448385000518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385000519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385000520 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 448385000521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385000522 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 448385000523 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 448385000524 DNA binding residues [nucleotide binding] 448385000525 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 448385000526 ArsC family; Region: ArsC; pfam03960 448385000527 catalytic residue [active] 448385000528 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 448385000529 PAS domain S-box; Region: sensory_box; TIGR00229 448385000530 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385000531 GAF domain; Region: GAF; pfam01590 448385000532 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385000533 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385000534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385000535 dimer interface [polypeptide binding]; other site 448385000536 phosphorylation site [posttranslational modification] 448385000537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385000538 ATP binding site [chemical binding]; other site 448385000539 Mg2+ binding site [ion binding]; other site 448385000540 G-X-G motif; other site 448385000541 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 448385000542 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385000543 Cytochrome P450; Region: p450; cl12078 448385000544 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385000545 cleavage site 448385000546 active site 448385000547 substrate binding sites [chemical binding]; other site 448385000548 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385000549 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 448385000550 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 448385000551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385000552 FeS/SAM binding site; other site 448385000553 GAF domain; Region: GAF_3; pfam13492 448385000554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385000555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385000556 dimer interface [polypeptide binding]; other site 448385000557 phosphorylation site [posttranslational modification] 448385000558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385000559 ATP binding site [chemical binding]; other site 448385000560 Mg2+ binding site [ion binding]; other site 448385000561 G-X-G motif; other site 448385000562 Response regulator receiver domain; Region: Response_reg; pfam00072 448385000563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385000564 active site 448385000565 phosphorylation site [posttranslational modification] 448385000566 intermolecular recognition site; other site 448385000567 dimerization interface [polypeptide binding]; other site 448385000568 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385000569 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385000570 dimer interface [polypeptide binding]; other site 448385000571 phosphorylation site [posttranslational modification] 448385000572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385000573 ATP binding site [chemical binding]; other site 448385000574 Mg2+ binding site [ion binding]; other site 448385000575 G-X-G motif; other site 448385000576 RecX family; Region: RecX; pfam02631 448385000577 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385000578 Domain of unknown function (DUF362); Region: DUF362; pfam04015 448385000579 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 448385000580 putative ligand binding site [chemical binding]; other site 448385000581 cobyric acid synthase; Provisional; Region: PRK00784 448385000582 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385000583 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 448385000584 catalytic triad [active] 448385000585 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 448385000586 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 448385000587 homotrimer interface [polypeptide binding]; other site 448385000588 Walker A motif; other site 448385000589 GTP binding site [chemical binding]; other site 448385000590 Walker B motif; other site 448385000591 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 448385000592 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 448385000593 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 448385000594 catalytic triad [active] 448385000595 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 448385000596 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 448385000597 Walker A motif; other site 448385000598 homodimer interface [polypeptide binding]; other site 448385000599 ATP binding site [chemical binding]; other site 448385000600 hydroxycobalamin binding site [chemical binding]; other site 448385000601 Walker B motif; other site 448385000602 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 448385000603 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 448385000604 active site 448385000605 SAM binding site [chemical binding]; other site 448385000606 homodimer interface [polypeptide binding]; other site 448385000607 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 448385000608 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000609 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000610 active site 448385000611 ATP binding site [chemical binding]; other site 448385000612 substrate binding site [chemical binding]; other site 448385000613 activation loop (A-loop); other site 448385000614 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385000615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000616 TPR motif; other site 448385000617 binding surface 448385000618 Uncharacterized conserved protein [Function unknown]; Region: COG4748 448385000619 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 448385000620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000621 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385000622 Walker A motif; other site 448385000623 ATP binding site [chemical binding]; other site 448385000624 Walker B motif; other site 448385000625 arginine finger; other site 448385000626 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000627 active site 448385000628 ATP binding site [chemical binding]; other site 448385000629 substrate binding site [chemical binding]; other site 448385000630 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 448385000631 activation loop (A-loop); other site 448385000632 cyclase homology domain; Region: CHD; cd07302 448385000633 dimer interface [polypeptide binding]; other site 448385000634 nucleotidyl binding site; other site 448385000635 metal binding site [ion binding]; metal-binding site 448385000636 AAA ATPase domain; Region: AAA_16; pfam13191 448385000637 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 448385000638 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 448385000639 Amidohydrolase; Region: Amidohydro_2; pfam04909 448385000640 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 448385000641 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 448385000642 YcaO-like family; Region: YcaO; pfam02624 448385000643 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 448385000644 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385000645 active site 448385000646 TIR domain; Region: TIR_2; pfam13676 448385000647 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385000648 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 448385000649 active site 448385000650 SAM binding site [chemical binding]; other site 448385000651 homodimer interface [polypeptide binding]; other site 448385000652 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 448385000653 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 448385000654 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 448385000655 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 448385000656 active site 448385000657 SAM binding site [chemical binding]; other site 448385000658 homodimer interface [polypeptide binding]; other site 448385000659 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 448385000660 active site 448385000661 putative homodimer interface [polypeptide binding]; other site 448385000662 SAM binding site [chemical binding]; other site 448385000663 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 448385000664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385000665 S-adenosylmethionine binding site [chemical binding]; other site 448385000666 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 448385000667 Precorrin-8X methylmutase; Region: CbiC; pfam02570 448385000668 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 448385000669 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 448385000670 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 448385000671 dimerization interface [polypeptide binding]; other site 448385000672 ATP binding site [chemical binding]; other site 448385000673 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 448385000674 dimerization interface [polypeptide binding]; other site 448385000675 ATP binding site [chemical binding]; other site 448385000676 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385000677 conserved cys residue [active] 448385000678 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 448385000679 FAD binding pocket [chemical binding]; other site 448385000680 conserved FAD binding motif [chemical binding]; other site 448385000681 phosphate binding motif [ion binding]; other site 448385000682 beta-alpha-beta structure motif; other site 448385000683 NAD binding pocket [chemical binding]; other site 448385000684 Protein of unknown function (DUF3209); Region: DUF3209; pfam11483 448385000685 Protein of unknown function (DUF1012); Region: DUF1012; pfam06241 448385000686 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 448385000687 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 448385000688 putative active site [active] 448385000689 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 448385000690 putative active site [active] 448385000691 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 448385000692 dimer interface [polypeptide binding]; other site 448385000693 [2Fe-2S] cluster binding site [ion binding]; other site 448385000694 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 448385000695 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 448385000696 Walker A/P-loop; other site 448385000697 ATP binding site [chemical binding]; other site 448385000698 Q-loop/lid; other site 448385000699 ABC transporter signature motif; other site 448385000700 Walker B; other site 448385000701 D-loop; other site 448385000702 H-loop/switch region; other site 448385000703 cobalt transport protein CbiM; Validated; Region: PRK08319 448385000704 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 448385000705 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 448385000706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385000707 substrate binding site [chemical binding]; other site 448385000708 oxyanion hole (OAH) forming residues; other site 448385000709 trimer interface [polypeptide binding]; other site 448385000710 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 448385000711 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 448385000712 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 448385000713 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385000714 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385000715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000716 TPR motif; other site 448385000717 binding surface 448385000718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000719 TPR motif; other site 448385000720 binding surface 448385000721 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000722 TPR motif; other site 448385000723 binding surface 448385000724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000725 TPR motif; other site 448385000726 binding surface 448385000727 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 448385000728 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 448385000729 homodimer interface [polypeptide binding]; other site 448385000730 substrate-cofactor binding pocket; other site 448385000731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385000732 catalytic residue [active] 448385000733 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 448385000734 homotrimer interaction site [polypeptide binding]; other site 448385000735 putative active site [active] 448385000736 recombination protein RecR; Reviewed; Region: recR; PRK00076 448385000737 RecR protein; Region: RecR; pfam02132 448385000738 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 448385000739 putative active site [active] 448385000740 putative metal-binding site [ion binding]; other site 448385000741 tetramer interface [polypeptide binding]; other site 448385000742 hypothetical protein; Validated; Region: PRK00153 448385000743 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 448385000744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000745 Walker A motif; other site 448385000746 ATP binding site [chemical binding]; other site 448385000747 Walker B motif; other site 448385000748 arginine finger; other site 448385000749 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 448385000750 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385000751 putative active site [active] 448385000752 AAA domain; Region: AAA_28; pfam13521 448385000753 Methyltransferase domain; Region: Methyltransf_24; pfam13578 448385000754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385000755 FeS/SAM binding site; other site 448385000756 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 448385000757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385000758 FeS/SAM binding site; other site 448385000759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385000760 CRISPR-associated helicase Cas3, subtype Dpsyc; Region: cas3_GSU0051; TIGR02621 448385000761 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 448385000762 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 448385000763 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 448385000764 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 448385000765 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 448385000766 DDE superfamily endonuclease; Region: DDE_5; pfam13546 448385000767 DDE superfamily endonuclease; Region: DDE_5; cl17874 448385000768 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385000769 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385000770 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385000771 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385000772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385000773 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385000774 Sel1-like repeats; Region: SEL1; smart00671 448385000775 Sel1-like repeats; Region: SEL1; smart00671 448385000776 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385000777 putative active site [active] 448385000778 replication factor A; Reviewed; Region: PRK12366 448385000779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000781 active site 448385000782 ATP binding site [chemical binding]; other site 448385000783 substrate binding site [chemical binding]; other site 448385000784 activation loop (A-loop); other site 448385000785 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385000786 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 448385000787 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385000788 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 448385000789 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 448385000790 heme-binding site [chemical binding]; other site 448385000791 short chain dehydrogenase; Provisional; Region: PRK06701 448385000792 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 448385000793 NAD binding site [chemical binding]; other site 448385000794 metal binding site [ion binding]; metal-binding site 448385000795 active site 448385000796 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 448385000797 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 448385000798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385000799 S-adenosylmethionine binding site [chemical binding]; other site 448385000800 pantothenate kinase; Reviewed; Region: PRK13321 448385000801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 448385000802 dimer interface [polypeptide binding]; other site 448385000803 putative PBP binding regions; other site 448385000804 ABC-ATPase subunit interface; other site 448385000805 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 448385000806 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 448385000807 active site 448385000808 8-oxo-dGMP binding site [chemical binding]; other site 448385000809 nudix motif; other site 448385000810 metal binding site [ion binding]; metal-binding site 448385000811 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385000812 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385000813 Double zinc ribbon; Region: DZR; pfam12773 448385000814 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385000815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385000816 phosphopeptide binding site; other site 448385000817 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385000818 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385000819 phosphopeptide binding site; other site 448385000820 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 448385000821 RuvA N terminal domain; Region: RuvA_N; pfam01330 448385000822 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 448385000823 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385000824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385000825 TPR motif; other site 448385000826 binding surface 448385000827 TPR repeat; Region: TPR_11; pfam13414 448385000828 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385000829 active site 448385000830 MYXO-CTERM domain; Region: MYXO-CTERM; TIGR03901 448385000831 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385000832 putative active site [active] 448385000833 Protein kinase domain; Region: Pkinase; pfam00069 448385000834 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000835 active site 448385000836 ATP binding site [chemical binding]; other site 448385000837 substrate binding site [chemical binding]; other site 448385000838 activation loop (A-loop); other site 448385000839 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 448385000840 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385000841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000842 Walker A motif; other site 448385000843 ATP binding site [chemical binding]; other site 448385000844 Walker B motif; other site 448385000845 arginine finger; other site 448385000846 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385000847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385000848 PGAP1-like protein; Region: PGAP1; pfam07819 448385000849 hypothetical protein; Provisional; Region: PRK01346 448385000850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 448385000851 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385000852 HSP70 interaction site [polypeptide binding]; other site 448385000853 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385000854 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000855 active site 448385000856 ATP binding site [chemical binding]; other site 448385000857 substrate binding site [chemical binding]; other site 448385000858 activation loop (A-loop); other site 448385000859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385000860 TPR motif; other site 448385000861 binding surface 448385000862 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 448385000863 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385000864 putative catalytic residue [active] 448385000865 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 448385000866 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385000867 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385000868 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385000869 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385000870 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 448385000871 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 448385000872 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 448385000873 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 448385000874 putative substrate binding site [chemical binding]; other site 448385000875 putative ATP binding site [chemical binding]; other site 448385000876 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385000877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385000878 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385000879 DNA binding residues [nucleotide binding] 448385000880 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 448385000881 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385000882 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385000883 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 448385000884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385000885 non-specific DNA binding site [nucleotide binding]; other site 448385000886 salt bridge; other site 448385000887 sequence-specific DNA binding site [nucleotide binding]; other site 448385000888 Cupin domain; Region: Cupin_2; pfam07883 448385000889 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 448385000890 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 448385000891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 448385000892 substrate binding pocket [chemical binding]; other site 448385000893 membrane-bound complex binding site; other site 448385000894 hinge residues; other site 448385000895 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 448385000896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385000897 dimer interface [polypeptide binding]; other site 448385000898 conserved gate region; other site 448385000899 putative PBP binding loops; other site 448385000900 ABC-ATPase subunit interface; other site 448385000901 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 448385000902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385000903 dimer interface [polypeptide binding]; other site 448385000904 conserved gate region; other site 448385000905 putative PBP binding loops; other site 448385000906 ABC-ATPase subunit interface; other site 448385000907 SET domain; Region: SET; pfam00856 448385000908 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 448385000909 Transglycosylase; Region: Transgly; pfam00912 448385000910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 448385000911 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 448385000912 Cytochrome c; Region: Cytochrom_C; pfam00034 448385000913 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 448385000914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385000915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000916 Walker A motif; other site 448385000917 ATP binding site [chemical binding]; other site 448385000918 Walker B motif; other site 448385000919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 448385000920 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 448385000921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385000922 Walker A motif; other site 448385000923 ATP binding site [chemical binding]; other site 448385000924 Walker B motif; other site 448385000925 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385000926 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 448385000927 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 448385000928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385000929 NAD(P) binding site [chemical binding]; other site 448385000930 active site 448385000931 Rubredoxin [Energy production and conversion]; Region: COG1773 448385000932 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 448385000933 iron binding site [ion binding]; other site 448385000934 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385000935 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 448385000936 nucleotide binding site [chemical binding]; other site 448385000937 N-acetyl-L-glutamate binding site [chemical binding]; other site 448385000938 hypothetical protein; Provisional; Region: PRK07338 448385000939 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 448385000940 metal binding site [ion binding]; metal-binding site 448385000941 dimer interface [polypeptide binding]; other site 448385000942 Protein kinase domain; Region: Pkinase; pfam00069 448385000943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385000944 active site 448385000945 ATP binding site [chemical binding]; other site 448385000946 substrate binding site [chemical binding]; other site 448385000947 activation loop (A-loop); other site 448385000948 AAA ATPase domain; Region: AAA_16; pfam13191 448385000949 Predicted ATPase [General function prediction only]; Region: COG3899 448385000950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385000951 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385000952 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385000953 Condensation domain; Region: Condensation; pfam00668 448385000954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385000955 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385000956 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 448385000957 acyl-activating enzyme (AAE) consensus motif; other site 448385000958 AMP binding site [chemical binding]; other site 448385000959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385000960 Condensation domain; Region: Condensation; pfam00668 448385000961 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385000962 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385000963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385000964 acyl-activating enzyme (AAE) consensus motif; other site 448385000965 AMP binding site [chemical binding]; other site 448385000966 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385000967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385000968 S-adenosylmethionine binding site [chemical binding]; other site 448385000969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385000970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385000971 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385000972 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385000973 active site 448385000974 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385000975 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 448385000976 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385000977 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 448385000978 Cupin domain; Region: Cupin_2; cl17218 448385000979 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 448385000980 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 448385000981 putative RNA binding site [nucleotide binding]; other site 448385000982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385000983 S-adenosylmethionine binding site [chemical binding]; other site 448385000984 Uncharacterized conserved protein [Function unknown]; Region: COG3287 448385000985 FIST N domain; Region: FIST; pfam08495 448385000986 FIST C domain; Region: FIST_C; pfam10442 448385000987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385000988 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385000989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 448385000990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385000991 dimer interface [polypeptide binding]; other site 448385000992 phosphorylation site [posttranslational modification] 448385000993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385000994 ATP binding site [chemical binding]; other site 448385000995 Mg2+ binding site [ion binding]; other site 448385000996 G-X-G motif; other site 448385000997 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 448385000998 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 448385000999 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001000 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001001 active site 448385001002 ATP binding site [chemical binding]; other site 448385001003 substrate binding site [chemical binding]; other site 448385001004 activation loop (A-loop); other site 448385001005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001006 TPR repeat; Region: TPR_11; pfam13414 448385001007 binding surface 448385001008 TPR motif; other site 448385001009 PEGA domain; Region: PEGA; pfam08308 448385001010 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 448385001011 fumarate hydratase; Provisional; Region: PRK15389 448385001012 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 448385001013 Fumarase C-terminus; Region: Fumerase_C; pfam05683 448385001014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385001015 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001017 active site 448385001018 ATP binding site [chemical binding]; other site 448385001019 substrate binding site [chemical binding]; other site 448385001020 activation loop (A-loop); other site 448385001021 PEGA domain; Region: PEGA; pfam08308 448385001022 trehalose synthase; Region: treS_nterm; TIGR02456 448385001023 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 448385001024 active site 448385001025 catalytic site [active] 448385001026 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 448385001027 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 448385001028 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001029 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001030 active site 448385001031 ATP binding site [chemical binding]; other site 448385001032 substrate binding site [chemical binding]; other site 448385001033 activation loop (A-loop); other site 448385001034 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 448385001035 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 448385001036 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 448385001037 heme bL binding site [chemical binding]; other site 448385001038 intrachain domain interface; other site 448385001039 interchain domain interface [polypeptide binding]; other site 448385001040 heme bH binding site [chemical binding]; other site 448385001041 Qo binding site; other site 448385001042 Cytochrome c; Region: Cytochrom_C; pfam00034 448385001043 Cytochrome c; Region: Cytochrom_C; pfam00034 448385001044 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 448385001045 iron-sulfur cluster [ion binding]; other site 448385001046 [2Fe-2S] cluster binding site [ion binding]; other site 448385001047 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385001048 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385001049 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 448385001050 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 448385001051 Cysteine-rich domain; Region: CCG; pfam02754 448385001052 Cysteine-rich domain; Region: CCG; pfam02754 448385001053 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 448385001054 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385001055 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 448385001056 LemA family; Region: LemA; cl00742 448385001057 Repair protein; Region: Repair_PSII; pfam04536 448385001058 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 448385001059 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 448385001060 dimer interface [polypeptide binding]; other site 448385001061 active site 448385001062 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 448385001063 active site 448385001064 CHAD domain; Region: CHAD; cl10506 448385001065 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 448385001066 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 448385001067 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 448385001068 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 448385001069 tandem repeat interface [polypeptide binding]; other site 448385001070 oligomer interface [polypeptide binding]; other site 448385001071 active site residues [active] 448385001072 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 448385001073 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 448385001074 tandem repeat interface [polypeptide binding]; other site 448385001075 oligomer interface [polypeptide binding]; other site 448385001076 active site residues [active] 448385001077 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 448385001078 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 448385001079 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 448385001080 active site 448385001081 dimer interface [polypeptide binding]; other site 448385001082 effector binding site; other site 448385001083 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 448385001084 TSCPD domain; Region: TSCPD; pfam12637 448385001085 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 448385001086 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 448385001087 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 448385001088 dimerization interface [polypeptide binding]; other site 448385001089 ATP binding site [chemical binding]; other site 448385001090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385001091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001092 dimer interface [polypeptide binding]; other site 448385001093 phosphorylation site [posttranslational modification] 448385001094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001095 ATP binding site [chemical binding]; other site 448385001096 Mg2+ binding site [ion binding]; other site 448385001097 G-X-G motif; other site 448385001098 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 448385001099 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 448385001100 G1 box; other site 448385001101 GTP/Mg2+ binding site [chemical binding]; other site 448385001102 G2 box; other site 448385001103 Switch I region; other site 448385001104 G3 box; other site 448385001105 Switch II region; other site 448385001106 G4 box; other site 448385001107 G5 box; other site 448385001108 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 448385001109 Dynamin family; Region: Dynamin_N; pfam00350 448385001110 G1 box; other site 448385001111 GTP/Mg2+ binding site [chemical binding]; other site 448385001112 G2 box; other site 448385001113 Switch I region; other site 448385001114 G3 box; other site 448385001115 Switch II region; other site 448385001116 G4 box; other site 448385001117 G5 box; other site 448385001118 Peptidase family M48; Region: Peptidase_M48; cl12018 448385001119 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 448385001120 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385001121 active site 448385001122 substrate binding site [chemical binding]; other site 448385001123 ATP binding site [chemical binding]; other site 448385001124 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 448385001125 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 448385001126 HflX GTPase family; Region: HflX; cd01878 448385001127 G1 box; other site 448385001128 GTP/Mg2+ binding site [chemical binding]; other site 448385001129 Switch I region; other site 448385001130 G2 box; other site 448385001131 G3 box; other site 448385001132 Switch II region; other site 448385001133 G4 box; other site 448385001134 G5 box; other site 448385001135 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385001136 PEGA domain; Region: PEGA; pfam08308 448385001137 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 448385001138 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 448385001139 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385001140 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385001141 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 448385001142 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 448385001143 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 448385001144 metal binding site [ion binding]; metal-binding site 448385001145 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 448385001146 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 448385001147 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385001148 Double zinc ribbon; Region: DZR; pfam12773 448385001149 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001150 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001151 active site 448385001152 ATP binding site [chemical binding]; other site 448385001153 substrate binding site [chemical binding]; other site 448385001154 activation loop (A-loop); other site 448385001155 elongation factor Tu; Reviewed; Region: PRK00049 448385001156 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 448385001157 G1 box; other site 448385001158 GEF interaction site [polypeptide binding]; other site 448385001159 GTP/Mg2+ binding site [chemical binding]; other site 448385001160 Switch I region; other site 448385001161 G2 box; other site 448385001162 G3 box; other site 448385001163 Switch II region; other site 448385001164 G4 box; other site 448385001165 G5 box; other site 448385001166 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 448385001167 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 448385001168 Antibiotic Binding Site [chemical binding]; other site 448385001169 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 448385001170 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 448385001171 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 448385001172 putative homodimer interface [polypeptide binding]; other site 448385001173 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 448385001174 heterodimer interface [polypeptide binding]; other site 448385001175 homodimer interface [polypeptide binding]; other site 448385001176 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 448385001177 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 448385001178 23S rRNA interface [nucleotide binding]; other site 448385001179 L7/L12 interface [polypeptide binding]; other site 448385001180 putative thiostrepton binding site; other site 448385001181 L25 interface [polypeptide binding]; other site 448385001182 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 448385001183 mRNA/rRNA interface [nucleotide binding]; other site 448385001184 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 448385001185 23S rRNA interface [nucleotide binding]; other site 448385001186 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 448385001187 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 448385001188 core dimer interface [polypeptide binding]; other site 448385001189 peripheral dimer interface [polypeptide binding]; other site 448385001190 L10 interface [polypeptide binding]; other site 448385001191 L11 interface [polypeptide binding]; other site 448385001192 putative EF-Tu interaction site [polypeptide binding]; other site 448385001193 putative EF-G interaction site [polypeptide binding]; other site 448385001194 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 448385001195 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 448385001196 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 448385001197 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 448385001198 RPB11 interaction site [polypeptide binding]; other site 448385001199 RPB12 interaction site [polypeptide binding]; other site 448385001200 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 448385001201 RPB3 interaction site [polypeptide binding]; other site 448385001202 RPB1 interaction site [polypeptide binding]; other site 448385001203 RPB11 interaction site [polypeptide binding]; other site 448385001204 RPB10 interaction site [polypeptide binding]; other site 448385001205 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 448385001206 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 448385001207 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 448385001208 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 448385001209 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 448385001210 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 448385001211 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 448385001212 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 448385001213 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 448385001214 DNA binding site [nucleotide binding] 448385001215 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 448385001216 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385001217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385001218 Zn2+ binding site [ion binding]; other site 448385001219 Mg2+ binding site [ion binding]; other site 448385001220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001221 Response regulator receiver domain; Region: Response_reg; pfam00072 448385001222 active site 448385001223 phosphorylation site [posttranslational modification] 448385001224 intermolecular recognition site; other site 448385001225 dimerization interface [polypeptide binding]; other site 448385001226 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385001227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385001228 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385001229 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 448385001230 oligomerization interface [polypeptide binding]; other site 448385001231 active site 448385001232 metal binding site [ion binding]; metal-binding site 448385001233 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385001234 FtsH Extracellular; Region: FtsH_ext; pfam06480 448385001235 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 448385001236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385001237 Walker B motif; other site 448385001238 arginine finger; other site 448385001239 Peptidase family M41; Region: Peptidase_M41; pfam01434 448385001240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001242 active site 448385001243 ATP binding site [chemical binding]; other site 448385001244 substrate binding site [chemical binding]; other site 448385001245 activation loop (A-loop); other site 448385001246 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385001247 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385001248 ligand binding site [chemical binding]; other site 448385001249 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385001250 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385001251 DnaJ domain; Region: DnaJ; pfam00226 448385001252 Helix-turn-helix domain; Region: HTH_25; pfam13413 448385001253 Uncharacterized conserved protein [Function unknown]; Region: COG4198 448385001254 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 448385001255 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 448385001256 active site residue [active] 448385001257 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 448385001258 Ligand binding site; other site 448385001259 Putative Catalytic site; other site 448385001260 DXD motif; other site 448385001261 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 448385001262 dimerization interface [polypeptide binding]; other site 448385001263 PAS fold; Region: PAS_4; pfam08448 448385001264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385001265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001266 dimer interface [polypeptide binding]; other site 448385001267 phosphorylation site [posttranslational modification] 448385001268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001269 ATP binding site [chemical binding]; other site 448385001270 Mg2+ binding site [ion binding]; other site 448385001271 G-X-G motif; other site 448385001272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001273 Response regulator receiver domain; Region: Response_reg; pfam00072 448385001274 active site 448385001275 phosphorylation site [posttranslational modification] 448385001276 intermolecular recognition site; other site 448385001277 dimerization interface [polypeptide binding]; other site 448385001278 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 448385001279 aspartate-rich region 2; other site 448385001280 substrate-Mg2+ binding site; other site 448385001281 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001282 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385001283 active site 448385001284 ATP binding site [chemical binding]; other site 448385001285 substrate binding site [chemical binding]; other site 448385001286 activation loop (A-loop); other site 448385001287 AAA ATPase domain; Region: AAA_16; pfam13191 448385001288 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 448385001289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385001290 DNA-binding site [nucleotide binding]; DNA binding site 448385001291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385001292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385001293 homodimer interface [polypeptide binding]; other site 448385001294 catalytic residue [active] 448385001295 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 448385001296 Uncharacterized conserved protein [Function unknown]; Region: COG2128 448385001297 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 448385001298 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385001299 acyl-activating enzyme (AAE) consensus motif; other site 448385001300 AMP binding site [chemical binding]; other site 448385001301 active site 448385001302 CoA binding site [chemical binding]; other site 448385001303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385001304 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 448385001305 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385001306 dimer interface [polypeptide binding]; other site 448385001307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385001308 catalytic residue [active] 448385001309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 448385001310 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385001311 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385001312 phosphopeptide binding site; other site 448385001313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385001314 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385001315 Walker A motif; other site 448385001316 ATP binding site [chemical binding]; other site 448385001317 Walker B motif; other site 448385001318 arginine finger; other site 448385001319 CsbD-like; Region: CsbD; cl17424 448385001320 Transglycosylase associated protein; Region: Transgly_assoc; pfam04226 448385001321 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 448385001322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385001323 catalytic residue [active] 448385001324 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 448385001325 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 448385001326 Cl- selectivity filter; other site 448385001327 Cl- binding residues [ion binding]; other site 448385001328 pore gating glutamate residue; other site 448385001329 dimer interface [polypeptide binding]; other site 448385001330 FOG: CBS domain [General function prediction only]; Region: COG0517 448385001331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385001332 MarR family; Region: MarR_2; pfam12802 448385001333 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 448385001334 dimer interface [polypeptide binding]; other site 448385001335 motif 1; other site 448385001336 active site 448385001337 motif 2; other site 448385001338 motif 3; other site 448385001339 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385001340 active site 448385001341 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 448385001342 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 448385001343 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 448385001344 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 448385001345 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385001346 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 448385001347 MPN+ (JAMM) motif; other site 448385001348 Zinc-binding site [ion binding]; other site 448385001349 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385001350 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385001351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385001352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385001353 non-specific DNA binding site [nucleotide binding]; other site 448385001354 salt bridge; other site 448385001355 sequence-specific DNA binding site [nucleotide binding]; other site 448385001356 integron integrase; Region: integrase_gron; TIGR02249 448385001357 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385001358 active site 448385001359 DNA binding site [nucleotide binding] 448385001360 Int/Topo IB signature motif; other site 448385001361 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385001362 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385001363 active site 448385001364 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 448385001365 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385001366 metal ion-dependent adhesion site (MIDAS); other site 448385001367 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 448385001368 Protein kinase domain; Region: Pkinase; pfam00069 448385001369 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001370 active site 448385001371 ATP binding site [chemical binding]; other site 448385001372 substrate binding site [chemical binding]; other site 448385001373 activation loop (A-loop); other site 448385001374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385001375 putative active site [active] 448385001376 Family description; Region: VCBS; pfam13517 448385001377 Family description; Region: VCBS; pfam13517 448385001378 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 448385001379 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385001380 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 448385001381 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385001382 NAD binding site [chemical binding]; other site 448385001383 catalytic Zn binding site [ion binding]; other site 448385001384 structural Zn binding site [ion binding]; other site 448385001385 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385001386 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385001387 metal ion-dependent adhesion site (MIDAS); other site 448385001388 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 448385001389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385001390 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385001391 Tetratricopeptide repeat; Region: TPR_10; cl17452 448385001392 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001394 active site 448385001395 ATP binding site [chemical binding]; other site 448385001396 substrate binding site [chemical binding]; other site 448385001397 activation loop (A-loop); other site 448385001398 PEGA domain; Region: PEGA; pfam08308 448385001399 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 448385001400 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 448385001401 active site 448385001402 homotetramer interface [polypeptide binding]; other site 448385001403 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 448385001404 Right handed beta helix region; Region: Beta_helix; pfam13229 448385001405 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 448385001406 putative active site [active] 448385001407 MgtE intracellular N domain; Region: MgtE_N; smart00924 448385001408 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 448385001409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 448385001410 Divalent cation transporter; Region: MgtE; pfam01769 448385001411 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 448385001412 catalytic core [active] 448385001413 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 448385001414 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 448385001415 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 448385001416 putative active site [active] 448385001417 putative substrate binding site [chemical binding]; other site 448385001418 putative cosubstrate binding site; other site 448385001419 catalytic site [active] 448385001420 60S ribosomal protein L19-like protein; Provisional; Region: PTZ00436 448385001421 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 448385001422 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 448385001423 C-terminal domain interface [polypeptide binding]; other site 448385001424 GSH binding site (G-site) [chemical binding]; other site 448385001425 dimer interface [polypeptide binding]; other site 448385001426 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 448385001427 N-terminal domain interface [polypeptide binding]; other site 448385001428 putative dimer interface [polypeptide binding]; other site 448385001429 active site 448385001430 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 448385001431 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 448385001432 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 448385001433 peptidase domain interface [polypeptide binding]; other site 448385001434 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 448385001435 active site 448385001436 catalytic triad [active] 448385001437 calcium binding site [ion binding]; other site 448385001438 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 448385001439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385001440 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385001441 Outer membrane efflux protein; Region: OEP; pfam02321 448385001442 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385001443 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385001444 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385001445 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 448385001446 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385001447 putative active site [active] 448385001448 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385001449 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385001450 putative active site [active] 448385001451 putative metal binding site [ion binding]; other site 448385001452 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 448385001453 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 448385001454 active site 448385001455 HIGH motif; other site 448385001456 dimer interface [polypeptide binding]; other site 448385001457 KMSKS motif; other site 448385001458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385001459 RNA binding surface [nucleotide binding]; other site 448385001460 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 448385001461 IHF dimer interface [polypeptide binding]; other site 448385001462 IHF - DNA interface [nucleotide binding]; other site 448385001463 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385001464 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385001465 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385001466 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385001467 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385001468 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385001469 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385001470 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385001471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385001472 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001473 dimer interface [polypeptide binding]; other site 448385001474 phosphorylation site [posttranslational modification] 448385001475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001476 ATP binding site [chemical binding]; other site 448385001477 Mg2+ binding site [ion binding]; other site 448385001478 G-X-G motif; other site 448385001479 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 448385001480 Partial alpha/beta-hydrolase lipase region; Region: Abhydro_lipase; pfam04083 448385001481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385001482 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385001483 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385001484 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385001485 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385001486 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 448385001487 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 448385001488 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 448385001489 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 448385001490 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 448385001491 NADH dehydrogenase subunit D; Validated; Region: PRK06075 448385001492 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 448385001493 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385001494 catalytic loop [active] 448385001495 iron binding site [ion binding]; other site 448385001496 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 448385001497 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 448385001498 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 448385001499 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 448385001500 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 448385001501 4Fe-4S binding domain; Region: Fer4; pfam00037 448385001502 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 448385001503 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 448385001504 GatB domain; Region: GatB_Yqey; smart00845 448385001505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385001506 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385001507 putative acyl-acceptor binding pocket; other site 448385001508 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385001509 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385001510 GAF domain; Region: GAF_3; pfam13492 448385001511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385001512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385001513 PAS domain; Region: PAS_9; pfam13426 448385001514 putative active site [active] 448385001515 heme pocket [chemical binding]; other site 448385001516 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385001517 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385001518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385001519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001520 dimer interface [polypeptide binding]; other site 448385001521 phosphorylation site [posttranslational modification] 448385001522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001523 ATP binding site [chemical binding]; other site 448385001524 Mg2+ binding site [ion binding]; other site 448385001525 G-X-G motif; other site 448385001526 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385001527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001528 active site 448385001529 phosphorylation site [posttranslational modification] 448385001530 intermolecular recognition site; other site 448385001531 dimerization interface [polypeptide binding]; other site 448385001532 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 448385001533 active site 448385001534 catalytic triad [active] 448385001535 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385001536 cleavage site 448385001537 active site 448385001538 substrate binding sites [chemical binding]; other site 448385001539 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 448385001540 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 448385001541 Peptidase M4 family containing mostly uncharacterized proteins; Region: M4_uncharacterized; cd09598 448385001542 Zn binding site [ion binding]; other site 448385001543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001545 active site 448385001546 ATP binding site [chemical binding]; other site 448385001547 substrate binding site [chemical binding]; other site 448385001548 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385001549 substrate binding site [chemical binding]; other site 448385001550 activation loop (A-loop); other site 448385001551 activation loop (A-loop); other site 448385001552 Predicted ATPase [General function prediction only]; Region: COG3899 448385001553 AAA ATPase domain; Region: AAA_16; pfam13191 448385001554 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 448385001555 YcaO-like family; Region: YcaO; pfam02624 448385001556 TfuA-like protein; Region: TfuA; pfam07812 448385001557 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 448385001558 peptidase domain interface [polypeptide binding]; other site 448385001559 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 448385001560 active site 448385001561 catalytic triad [active] 448385001562 calcium binding site [ion binding]; other site 448385001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385001564 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385001565 Walker A motif; other site 448385001566 ATP binding site [chemical binding]; other site 448385001567 Walker B motif; other site 448385001568 arginine finger; other site 448385001569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385001570 putative Mg++ binding site [ion binding]; other site 448385001571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385001572 nucleotide binding region [chemical binding]; other site 448385001573 ATP-binding site [chemical binding]; other site 448385001574 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 448385001575 putative metal binding site [ion binding]; other site 448385001576 putative homodimer interface [polypeptide binding]; other site 448385001577 putative homotetramer interface [polypeptide binding]; other site 448385001578 putative homodimer-homodimer interface [polypeptide binding]; other site 448385001579 putative allosteric switch controlling residues; other site 448385001580 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 448385001581 Predicted membrane protein [Function unknown]; Region: COG1971 448385001582 Domain of unknown function DUF; Region: DUF204; pfam02659 448385001583 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 448385001584 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385001585 active site 448385001586 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385001587 NHL repeat; Region: NHL; pfam01436 448385001588 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385001589 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385001590 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 448385001591 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385001592 metal ion-dependent adhesion site (MIDAS); other site 448385001593 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385001594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385001595 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385001596 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385001597 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385001598 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385001599 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 448385001600 putative metal binding site [ion binding]; other site 448385001601 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 448385001602 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385001603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385001604 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385001605 DNA binding residues [nucleotide binding] 448385001606 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 448385001607 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 448385001608 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 448385001609 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385001610 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 448385001611 Part of AAA domain; Region: AAA_19; pfam13245 448385001612 Family description; Region: UvrD_C_2; pfam13538 448385001613 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 448385001614 heme-binding site [chemical binding]; other site 448385001615 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 448385001616 heme-binding site [chemical binding]; other site 448385001617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001618 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001619 active site 448385001620 ATP binding site [chemical binding]; other site 448385001621 substrate binding site [chemical binding]; other site 448385001622 activation loop (A-loop); other site 448385001623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385001624 AAA domain; Region: AAA_22; pfam13401 448385001625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385001626 H+ Antiporter protein; Region: 2A0121; TIGR00900 448385001627 putative substrate translocation pore; other site 448385001628 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385001629 active site 448385001630 HIGH motif; other site 448385001631 nucleotide binding site [chemical binding]; other site 448385001632 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385001633 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 448385001634 active site 448385001635 HIGH motif; other site 448385001636 nucleotide binding site [chemical binding]; other site 448385001637 active site 448385001638 KMSKS motif; other site 448385001639 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322 448385001640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 448385001641 dimerization interface [polypeptide binding]; other site 448385001642 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 448385001643 cyclase homology domain; Region: CHD; cd07302 448385001644 nucleotidyl binding site; other site 448385001645 metal binding site [ion binding]; metal-binding site 448385001646 dimer interface [polypeptide binding]; other site 448385001647 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 448385001648 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 448385001649 putative dimer interface [polypeptide binding]; other site 448385001650 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 448385001651 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 448385001652 putative dimer interface [polypeptide binding]; other site 448385001653 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 448385001654 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 448385001655 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 448385001656 DNA binding residues [nucleotide binding] 448385001657 B12 binding domain; Region: B12-binding_2; pfam02607 448385001658 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 448385001659 B12 binding domain; Region: B12-binding; pfam02310 448385001660 phytoene desaturase; Region: crtI_fam; TIGR02734 448385001661 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385001662 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 448385001663 active site lid residues [active] 448385001664 substrate binding pocket [chemical binding]; other site 448385001665 catalytic residues [active] 448385001666 substrate-Mg2+ binding site; other site 448385001667 aspartate-rich region 1; other site 448385001668 aspartate-rich region 2; other site 448385001669 beta-carotene hydroxylase; Region: PLN02601 448385001670 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 448385001671 phytoene desaturase; Region: crtI_fam; TIGR02734 448385001672 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 448385001673 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 448385001674 substrate binding pocket [chemical binding]; other site 448385001675 chain length determination region; other site 448385001676 substrate-Mg2+ binding site; other site 448385001677 catalytic residues [active] 448385001678 aspartate-rich region 1; other site 448385001679 active site lid residues [active] 448385001680 aspartate-rich region 2; other site 448385001681 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385001682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385001683 active site 448385001684 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 448385001685 putative active site [active] 448385001686 putative catalytic site [active] 448385001687 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385001688 active site 2 [active] 448385001689 active site 1 [active] 448385001690 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385001691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385001692 putative active site [active] 448385001693 heme pocket [chemical binding]; other site 448385001694 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 448385001695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001696 dimer interface [polypeptide binding]; other site 448385001697 phosphorylation site [posttranslational modification] 448385001698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001699 ATP binding site [chemical binding]; other site 448385001700 Mg2+ binding site [ion binding]; other site 448385001701 G-X-G motif; other site 448385001702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001703 Response regulator receiver domain; Region: Response_reg; pfam00072 448385001704 active site 448385001705 phosphorylation site [posttranslational modification] 448385001706 intermolecular recognition site; other site 448385001707 dimerization interface [polypeptide binding]; other site 448385001708 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385001709 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385001710 ligand binding site [chemical binding]; other site 448385001711 flexible hinge region; other site 448385001712 Putative methyltransferase; Region: Methyltransf_20; pfam12147 448385001713 Aspartyl protease; Region: Asp_protease_2; pfam13650 448385001714 inhibitor binding site; inhibition site 448385001715 catalytic motif [active] 448385001716 Catalytic residue [active] 448385001717 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 448385001718 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 448385001719 substrate binding site [chemical binding]; other site 448385001720 dimer interface [polypeptide binding]; other site 448385001721 ATP binding site [chemical binding]; other site 448385001722 von Willebrand factor; Region: vWF_A; pfam12450 448385001723 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385001724 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 448385001725 metal ion-dependent adhesion site (MIDAS); other site 448385001726 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 448385001727 NAD-dependent deacetylase; Provisional; Region: PRK00481 448385001728 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 448385001729 NAD+ binding site [chemical binding]; other site 448385001730 substrate binding site [chemical binding]; other site 448385001731 Zn binding site [ion binding]; other site 448385001732 Uncharacterized conserved protein [Function unknown]; Region: COG2155 448385001733 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385001734 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 448385001735 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 448385001736 tetramer interface [polypeptide binding]; other site 448385001737 active site 448385001738 Mg2+/Mn2+ binding site [ion binding]; other site 448385001739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385001740 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385001741 active site 448385001742 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385001743 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 448385001744 putative C-terminal domain interface [polypeptide binding]; other site 448385001745 putative GSH binding site (G-site) [chemical binding]; other site 448385001746 putative dimer interface [polypeptide binding]; other site 448385001747 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 448385001748 putative dimer interface [polypeptide binding]; other site 448385001749 putative N-terminal domain interface [polypeptide binding]; other site 448385001750 putative substrate binding pocket (H-site) [chemical binding]; other site 448385001751 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385001752 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385001753 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385001754 N-terminal domain interface [polypeptide binding]; other site 448385001755 dimer interface [polypeptide binding]; other site 448385001756 substrate binding pocket (H-site) [chemical binding]; other site 448385001757 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385001758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385001759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 448385001760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385001761 Coenzyme A binding pocket [chemical binding]; other site 448385001762 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 448385001763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001764 binding surface 448385001765 TPR motif; other site 448385001766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001767 binding surface 448385001768 TPR motif; other site 448385001769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001770 TPR motif; other site 448385001771 binding surface 448385001772 TPR repeat; Region: TPR_11; pfam13414 448385001773 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001774 binding surface 448385001775 TPR motif; other site 448385001776 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385001777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001778 binding surface 448385001779 TPR motif; other site 448385001780 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 448385001781 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650 448385001782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001783 binding surface 448385001784 TPR motif; other site 448385001785 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385001786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001787 binding surface 448385001788 TPR motif; other site 448385001789 Flagellin N-methylase; Region: FliB; pfam03692 448385001790 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 448385001791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385001792 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 448385001793 Permease; Region: Permease; pfam02405 448385001794 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 448385001795 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 448385001796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385001797 active site 448385001798 HIGH motif; other site 448385001799 nucleotide binding site [chemical binding]; other site 448385001800 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 448385001801 KMSKS motif; other site 448385001802 chaperone protein DnaJ; Provisional; Region: PRK14299 448385001803 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385001804 HSP70 interaction site [polypeptide binding]; other site 448385001805 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 448385001806 substrate binding site [polypeptide binding]; other site 448385001807 dimer interface [polypeptide binding]; other site 448385001808 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001809 active site 448385001810 ATP binding site [chemical binding]; other site 448385001811 substrate binding site [chemical binding]; other site 448385001812 activation loop (A-loop); other site 448385001813 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 448385001814 chorismate binding enzyme; Region: Chorismate_bind; cl10555 448385001815 chorismate binding enzyme; Region: Chorismate_bind; cl10555 448385001816 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385001817 catalytic residues [active] 448385001818 Response regulator receiver domain; Region: Response_reg; pfam00072 448385001819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001820 active site 448385001821 phosphorylation site [posttranslational modification] 448385001822 intermolecular recognition site; other site 448385001823 dimerization interface [polypeptide binding]; other site 448385001824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385001825 non-specific DNA binding site [nucleotide binding]; other site 448385001826 salt bridge; other site 448385001827 sequence-specific DNA binding site [nucleotide binding]; other site 448385001828 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385001829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385001830 putative active site [active] 448385001831 heme pocket [chemical binding]; other site 448385001832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385001833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385001834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385001835 dimer interface [polypeptide binding]; other site 448385001836 phosphorylation site [posttranslational modification] 448385001837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385001838 ATP binding site [chemical binding]; other site 448385001839 Mg2+ binding site [ion binding]; other site 448385001840 G-X-G motif; other site 448385001841 Response regulator receiver domain; Region: Response_reg; pfam00072 448385001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385001843 active site 448385001844 phosphorylation site [posttranslational modification] 448385001845 intermolecular recognition site; other site 448385001846 dimerization interface [polypeptide binding]; other site 448385001847 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 448385001848 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 448385001849 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 448385001850 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 448385001851 Ligand binding site [chemical binding]; other site 448385001852 Electron transfer flavoprotein domain; Region: ETF; pfam01012 448385001853 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385001854 DNA binding residues [nucleotide binding] 448385001855 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001856 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001857 active site 448385001858 ATP binding site [chemical binding]; other site 448385001859 substrate binding site [chemical binding]; other site 448385001860 activation loop (A-loop); other site 448385001861 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001862 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001863 active site 448385001864 ATP binding site [chemical binding]; other site 448385001865 substrate binding site [chemical binding]; other site 448385001866 activation loop (A-loop); other site 448385001867 TPR repeat; Region: TPR_11; pfam13414 448385001868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001869 TPR motif; other site 448385001870 PEGA domain; Region: PEGA; pfam08308 448385001871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385001872 TPR motif; other site 448385001873 PEGA domain; Region: PEGA; pfam08308 448385001874 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 448385001875 L-aspartate oxidase; Provisional; Region: PRK09077 448385001876 L-aspartate oxidase; Provisional; Region: PRK06175 448385001877 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 448385001878 CAAX protease self-immunity; Region: Abi; pfam02517 448385001879 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 448385001880 hypothetical protein; Provisional; Region: PRK01842 448385001881 SEC-C motif; Region: SEC-C; pfam02810 448385001882 RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717 448385001883 Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573 448385001884 dimethylated arginine/lysine binding site [chemical binding]; other site 448385001885 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 448385001886 elongation factor G; Reviewed; Region: PRK12740 448385001887 G1 box; other site 448385001888 putative GEF interaction site [polypeptide binding]; other site 448385001889 GTP/Mg2+ binding site [chemical binding]; other site 448385001890 Switch I region; other site 448385001891 G2 box; other site 448385001892 G3 box; other site 448385001893 Switch II region; other site 448385001894 G4 box; other site 448385001895 G5 box; other site 448385001896 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 448385001897 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 448385001898 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 448385001899 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385001900 Walker A motif; other site 448385001901 ATP binding site [chemical binding]; other site 448385001902 Walker B motif; other site 448385001903 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385001904 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385001905 ligand binding site [chemical binding]; other site 448385001906 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 448385001907 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 448385001908 Gram-negative bacterial tonB protein; Region: TonB; cl10048 448385001909 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 448385001910 TolB amino-terminal domain; Region: TolB_N; pfam04052 448385001911 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385001912 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385001913 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385001914 active site 448385001915 ATP binding site [chemical binding]; other site 448385001916 substrate binding site [chemical binding]; other site 448385001917 activation loop (A-loop); other site 448385001918 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385001919 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385001920 phosphopeptide binding site; other site 448385001921 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 448385001922 dimer interface [polypeptide binding]; other site 448385001923 substrate binding site [chemical binding]; other site 448385001924 ATP binding site [chemical binding]; other site 448385001925 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 448385001926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385001927 Walker A/P-loop; other site 448385001928 ATP binding site [chemical binding]; other site 448385001929 Q-loop/lid; other site 448385001930 ABC transporter signature motif; other site 448385001931 Walker B; other site 448385001932 D-loop; other site 448385001933 H-loop/switch region; other site 448385001934 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 448385001935 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 448385001936 CAAX protease self-immunity; Region: Abi; pfam02517 448385001937 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385001938 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385001939 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 448385001940 DNA binding site [nucleotide binding] 448385001941 domain linker motif; other site 448385001942 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385001943 ligand binding site [chemical binding]; other site 448385001944 dimerization interface [polypeptide binding]; other site 448385001945 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 448385001946 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 448385001947 phosphoserine phosphatase SerB; Region: serB; TIGR00338 448385001948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385001949 motif II; other site 448385001950 excinuclease ABC subunit B; Provisional; Region: PRK05298 448385001951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385001952 ATP binding site [chemical binding]; other site 448385001953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385001954 nucleotide binding region [chemical binding]; other site 448385001955 ATP-binding site [chemical binding]; other site 448385001956 Ultra-violet resistance protein B; Region: UvrB; pfam12344 448385001957 UvrB/uvrC motif; Region: UVR; pfam02151 448385001958 GTPase RsgA; Reviewed; Region: PRK01889 448385001959 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 448385001960 GTPase/Zn-binding domain interface [polypeptide binding]; other site 448385001961 GTP/Mg2+ binding site [chemical binding]; other site 448385001962 G4 box; other site 448385001963 G5 box; other site 448385001964 G1 box; other site 448385001965 Switch I region; other site 448385001966 G2 box; other site 448385001967 G3 box; other site 448385001968 Switch II region; other site 448385001969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385001970 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385001971 phosphopeptide binding site; other site 448385001972 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 448385001973 GAF domain; Region: GAF; cl17456 448385001974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385001975 Walker A motif; other site 448385001976 ATP binding site [chemical binding]; other site 448385001977 Walker B motif; other site 448385001978 arginine finger; other site 448385001979 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385001980 HEAT repeats; Region: HEAT_2; pfam13646 448385001981 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 448385001982 short chain dehydrogenase; Provisional; Region: PRK06914 448385001983 NADP binding site [chemical binding]; other site 448385001984 active site 448385001985 steroid binding site; other site 448385001986 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 448385001987 hydroxyglutarate oxidase; Provisional; Region: PRK11728 448385001988 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 448385001989 active site 448385001990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385001991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385001992 active site 448385001993 catalytic tetrad [active] 448385001994 Pectinacetylesterase; Region: PAE; pfam03283 448385001995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 448385001996 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 448385001997 nucleotide binding site [chemical binding]; other site 448385001998 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385001999 Cytochrome P450; Region: p450; cl12078 448385002000 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 448385002001 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 448385002002 NAD(P) binding site [chemical binding]; other site 448385002003 catalytic residues [active] 448385002004 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385002005 active site 448385002006 metal binding site [ion binding]; metal-binding site 448385002007 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 448385002008 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 448385002009 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 448385002010 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385002011 DNA binding residues [nucleotide binding] 448385002012 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002013 active site 448385002014 ATP binding site [chemical binding]; other site 448385002015 substrate binding site [chemical binding]; other site 448385002016 activation loop (A-loop); other site 448385002017 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385002018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385002019 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385002020 phosphopeptide binding site; other site 448385002021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385002022 Walker A motif; other site 448385002023 ATP binding site [chemical binding]; other site 448385002024 Walker B motif; other site 448385002025 arginine finger; other site 448385002026 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385002027 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385002028 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002029 active site 448385002030 ATP binding site [chemical binding]; other site 448385002031 substrate binding site [chemical binding]; other site 448385002032 activation loop (A-loop); other site 448385002033 Bacterial Ig-like domain; Region: Big_5; pfam13205 448385002034 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 448385002035 generic binding surface I; other site 448385002036 generic binding surface II; other site 448385002037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385002038 putative catalytic site [active] 448385002039 putative metal binding site [ion binding]; other site 448385002040 putative phosphate binding site [ion binding]; other site 448385002041 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 448385002042 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385002043 B12 binding site [chemical binding]; other site 448385002044 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385002045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385002046 FeS/SAM binding site; other site 448385002047 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385002048 Di-iron ligands [ion binding]; other site 448385002049 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 448385002050 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385002051 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 448385002052 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385002053 inhibitor-cofactor binding pocket; inhibition site 448385002054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385002055 catalytic residue [active] 448385002056 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 448385002057 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385002058 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385002059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385002060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385002061 DNA binding residues [nucleotide binding] 448385002062 Putative zinc-finger; Region: zf-HC2; pfam13490 448385002063 helicase 45; Provisional; Region: PTZ00424 448385002064 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 448385002065 ATP binding site [chemical binding]; other site 448385002066 Mg++ binding site [ion binding]; other site 448385002067 motif III; other site 448385002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385002069 nucleotide binding region [chemical binding]; other site 448385002070 ATP-binding site [chemical binding]; other site 448385002071 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 448385002072 RNA binding site [nucleotide binding]; other site 448385002073 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 448385002074 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 448385002075 active site 448385002076 dimer interface [polypeptide binding]; other site 448385002077 Cna protein B-type domain; Region: Cna_B_2; pfam13715 448385002078 MarC family integral membrane protein; Region: MarC; cl00919 448385002079 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385002080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385002081 PAS domain; Region: PAS_9; pfam13426 448385002082 putative active site [active] 448385002083 heme pocket [chemical binding]; other site 448385002084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385002085 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385002086 NAD(P) binding site [chemical binding]; other site 448385002087 active site 448385002088 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 448385002089 Cupin; Region: Cupin_6; pfam12852 448385002090 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385002091 Right handed beta helix region; Region: Beta_helix; pfam13229 448385002092 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 448385002093 aromatic chitin/cellulose binding site residues [chemical binding]; other site 448385002094 putative glutathione S-transferase; Provisional; Region: PRK10357 448385002095 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 448385002096 putative C-terminal domain interface [polypeptide binding]; other site 448385002097 putative GSH binding site (G-site) [chemical binding]; other site 448385002098 putative dimer interface [polypeptide binding]; other site 448385002099 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 448385002100 dimer interface [polypeptide binding]; other site 448385002101 N-terminal domain interface [polypeptide binding]; other site 448385002102 putative substrate binding pocket (H-site) [chemical binding]; other site 448385002103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385002104 dimerization interface [polypeptide binding]; other site 448385002105 putative DNA binding site [nucleotide binding]; other site 448385002106 putative Zn2+ binding site [ion binding]; other site 448385002107 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 448385002108 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 448385002109 GIY-YIG motif/motif A; other site 448385002110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002111 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002112 phosphorylation site [posttranslational modification] 448385002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002114 ATP binding site [chemical binding]; other site 448385002115 Mg2+ binding site [ion binding]; other site 448385002116 G-X-G motif; other site 448385002117 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002119 active site 448385002120 phosphorylation site [posttranslational modification] 448385002121 intermolecular recognition site; other site 448385002122 dimerization interface [polypeptide binding]; other site 448385002123 PAS fold; Region: PAS_4; pfam08448 448385002124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002126 dimer interface [polypeptide binding]; other site 448385002127 phosphorylation site [posttranslational modification] 448385002128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002129 ATP binding site [chemical binding]; other site 448385002130 Mg2+ binding site [ion binding]; other site 448385002131 G-X-G motif; other site 448385002132 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002134 active site 448385002135 phosphorylation site [posttranslational modification] 448385002136 intermolecular recognition site; other site 448385002137 dimerization interface [polypeptide binding]; other site 448385002138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385002139 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385002140 active site 448385002141 catalytic tetrad [active] 448385002142 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385002143 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385002144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385002145 catalytic residue [active] 448385002146 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 448385002147 dimer interface [polypeptide binding]; other site 448385002148 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385002149 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385002150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002151 active site 448385002152 phosphorylation site [posttranslational modification] 448385002153 intermolecular recognition site; other site 448385002154 dimerization interface [polypeptide binding]; other site 448385002155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385002156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002158 ATP binding site [chemical binding]; other site 448385002159 Mg2+ binding site [ion binding]; other site 448385002160 G-X-G motif; other site 448385002161 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002163 active site 448385002164 phosphorylation site [posttranslational modification] 448385002165 intermolecular recognition site; other site 448385002166 dimerization interface [polypeptide binding]; other site 448385002167 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 448385002168 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 448385002169 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 448385002170 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385002171 putative active site [active] 448385002172 putative NTP binding site [chemical binding]; other site 448385002173 putative nucleic acid binding site [nucleotide binding]; other site 448385002174 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 448385002175 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385002176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385002177 NAD(P) binding site [chemical binding]; other site 448385002178 active site 448385002179 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385002180 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 448385002181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385002182 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385002183 FeS/SAM binding site; other site 448385002184 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385002185 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385002186 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385002187 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385002188 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385002189 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385002190 V4R domain; Region: V4R; cl15268 448385002191 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385002192 Cupin domain; Region: Cupin_2; cl17218 448385002193 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 448385002194 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 448385002195 ligand-binding site [chemical binding]; other site 448385002196 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 448385002197 ATP-sulfurylase; Region: ATPS; cd00517 448385002198 active site 448385002199 HXXH motif; other site 448385002200 flexible loop; other site 448385002201 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 448385002202 sulfotransferase; Region: PLN02164 448385002203 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 448385002204 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385002205 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385002206 putative sugar binding sites [chemical binding]; other site 448385002207 Q-X-W motif; other site 448385002208 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385002209 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385002210 Transcriptional regulators [Transcription]; Region: FadR; COG2186 448385002211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385002212 DNA-binding site [nucleotide binding]; DNA binding site 448385002213 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 448385002214 FAD binding domain; Region: FAD_binding_4; pfam01565 448385002215 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 448385002216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385002217 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 448385002218 Walker A/P-loop; other site 448385002219 ATP binding site [chemical binding]; other site 448385002220 Q-loop/lid; other site 448385002221 ABC transporter signature motif; other site 448385002222 Walker B; other site 448385002223 D-loop; other site 448385002224 H-loop/switch region; other site 448385002225 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 448385002226 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385002227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385002228 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385002229 hypothetical protein; Provisional; Region: PRK06446 448385002230 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 448385002231 metal binding site [ion binding]; metal-binding site 448385002232 dimer interface [polypeptide binding]; other site 448385002233 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 448385002234 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385002235 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385002236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 448385002237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 448385002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 448385002239 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385002240 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385002241 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385002242 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385002243 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385002244 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385002245 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385002246 putative effector binding pocket; other site 448385002247 dimerization interface [polypeptide binding]; other site 448385002248 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 448385002249 CotH protein; Region: CotH; pfam08757 448385002250 hydroxylamine reductase; Provisional; Region: PRK12310 448385002251 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 448385002252 ACS interaction site; other site 448385002253 CODH interaction site; other site 448385002254 metal cluster binding site [ion binding]; other site 448385002255 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385002256 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385002257 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385002258 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 448385002259 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385002260 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 448385002261 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385002262 putative binding surface; other site 448385002263 active site 448385002264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002265 ATP binding site [chemical binding]; other site 448385002266 Mg2+ binding site [ion binding]; other site 448385002267 G-X-G motif; other site 448385002268 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385002269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002270 active site 448385002271 phosphorylation site [posttranslational modification] 448385002272 intermolecular recognition site; other site 448385002273 dimerization interface [polypeptide binding]; other site 448385002274 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385002275 dimerization interface [polypeptide binding]; other site 448385002276 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 448385002277 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 448385002278 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 448385002279 dimer interface [polypeptide binding]; other site 448385002280 putative CheW interface [polypeptide binding]; other site 448385002281 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 448385002282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 448385002283 active site 448385002284 phosphorylation site [posttranslational modification] 448385002285 intermolecular recognition site; other site 448385002286 dimerization interface [polypeptide binding]; other site 448385002287 CheW-like domain; Region: CheW; pfam01584 448385002288 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385002289 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385002290 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 448385002291 Putative methyltransferase; Region: Methyltransf_4; cl17290 448385002292 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385002293 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385002294 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385002295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385002296 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385002297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002298 active site 448385002299 ATP binding site [chemical binding]; other site 448385002300 substrate binding site [chemical binding]; other site 448385002301 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 448385002302 activation loop (A-loop); other site 448385002303 cyclase homology domain; Region: CHD; cd07302 448385002304 dimer interface [polypeptide binding]; other site 448385002305 nucleotidyl binding site; other site 448385002306 metal binding site [ion binding]; metal-binding site 448385002307 AAA ATPase domain; Region: AAA_16; pfam13191 448385002308 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 448385002309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385002310 Coenzyme A binding pocket [chemical binding]; other site 448385002311 TfuA-like protein; Region: TfuA; pfam07812 448385002312 Uncharacterized conserved protein [Function unknown]; Region: COG1944 448385002313 YcaO-like family; Region: YcaO; pfam02624 448385002314 COMPASS (Complex proteins associated with Set1p) component N; Region: N-SET; pfam11764 448385002315 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385002316 phosphopeptide binding site; other site 448385002317 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385002318 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002319 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 448385002320 dimer interface [polypeptide binding]; other site 448385002321 phosphorylation site [posttranslational modification] 448385002322 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002323 ATP binding site [chemical binding]; other site 448385002324 Mg2+ binding site [ion binding]; other site 448385002325 G-X-G motif; other site 448385002326 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002327 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002328 active site 448385002329 ATP binding site [chemical binding]; other site 448385002330 substrate binding site [chemical binding]; other site 448385002331 activation loop (A-loop); other site 448385002332 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002334 active site 448385002335 phosphorylation site [posttranslational modification] 448385002336 intermolecular recognition site; other site 448385002337 dimerization interface [polypeptide binding]; other site 448385002338 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 448385002339 cyclase homology domain; Region: CHD; cd07302 448385002340 nucleotidyl binding site; other site 448385002341 metal binding site [ion binding]; metal-binding site 448385002342 dimer interface [polypeptide binding]; other site 448385002343 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385002344 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385002345 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385002346 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385002347 Right handed beta helix region; Region: Beta_helix; pfam13229 448385002348 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385002349 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385002350 Multicopper oxidase; Region: Cu-oxidase; pfam00394 448385002351 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385002352 PhoD-like phosphatase; Region: PhoD; pfam09423 448385002353 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 448385002354 putative active site [active] 448385002355 putative metal binding site [ion binding]; other site 448385002356 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 448385002357 Nitrate and nitrite sensing; Region: NIT; pfam08376 448385002358 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 448385002359 dimerization interface [polypeptide binding]; other site 448385002360 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 448385002361 putative binding surface; other site 448385002362 active site 448385002363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002364 ATP binding site [chemical binding]; other site 448385002365 Mg2+ binding site [ion binding]; other site 448385002366 G-X-G motif; other site 448385002367 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 448385002368 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002370 active site 448385002371 phosphorylation site [posttranslational modification] 448385002372 intermolecular recognition site; other site 448385002373 dimerization interface [polypeptide binding]; other site 448385002374 short chain dehydrogenase; Provisional; Region: PRK06181 448385002375 classical (c) SDRs; Region: SDR_c; cd05233 448385002376 NAD(P) binding site [chemical binding]; other site 448385002377 active site 448385002378 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 448385002379 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 448385002380 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385002381 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385002382 Di-iron ligands [ion binding]; other site 448385002383 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385002384 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385002385 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385002386 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 448385002387 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 448385002388 PAS fold; Region: PAS_4; pfam08448 448385002389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385002390 putative active site [active] 448385002391 heme pocket [chemical binding]; other site 448385002392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002394 ATP binding site [chemical binding]; other site 448385002395 Mg2+ binding site [ion binding]; other site 448385002396 G-X-G motif; other site 448385002397 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002399 active site 448385002400 phosphorylation site [posttranslational modification] 448385002401 intermolecular recognition site; other site 448385002402 dimerization interface [polypeptide binding]; other site 448385002403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002405 dimer interface [polypeptide binding]; other site 448385002406 phosphorylation site [posttranslational modification] 448385002407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002408 ATP binding site [chemical binding]; other site 448385002409 Mg2+ binding site [ion binding]; other site 448385002410 G-X-G motif; other site 448385002411 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 448385002412 FMN binding site [chemical binding]; other site 448385002413 substrate binding site [chemical binding]; other site 448385002414 putative catalytic residue [active] 448385002415 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385002416 3-oxoacyl-acyl carrier protein synthase; Provisional; Region: PTZ00050 448385002417 active site 448385002418 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385002419 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 448385002420 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385002421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385002422 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385002423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385002424 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385002425 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385002426 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385002427 putative NADP binding site [chemical binding]; other site 448385002428 active site 448385002429 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385002430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385002431 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 448385002432 active site 448385002433 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385002434 active site 448385002435 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385002436 active site 2 [active] 448385002437 active site 1 [active] 448385002438 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 448385002439 active site 1 [active] 448385002440 dimer interface [polypeptide binding]; other site 448385002441 active site 2 [active] 448385002442 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385002443 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 448385002444 active site 1 [active] 448385002445 dimer interface [polypeptide binding]; other site 448385002446 active site 2 [active] 448385002447 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385002448 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 448385002449 putative acyl-acceptor binding pocket; other site 448385002450 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 448385002451 Predicted ATPase [General function prediction only]; Region: COG4637 448385002452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385002453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385002454 Walker A/P-loop; other site 448385002455 Walker A/P-loop; other site 448385002456 ATP binding site [chemical binding]; other site 448385002457 ATP binding site [chemical binding]; other site 448385002458 Q-loop/lid; other site 448385002459 ABC transporter signature motif; other site 448385002460 PEGA domain; Region: PEGA; pfam08308 448385002461 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385002462 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385002463 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385002464 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385002465 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002466 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002467 active site 448385002468 ATP binding site [chemical binding]; other site 448385002469 substrate binding site [chemical binding]; other site 448385002470 activation loop (A-loop); other site 448385002471 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002473 active site 448385002474 ATP binding site [chemical binding]; other site 448385002475 substrate binding site [chemical binding]; other site 448385002476 activation loop (A-loop); other site 448385002477 Tetratricopeptide repeat; Region: TPR_6; pfam13174 448385002478 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385002479 metal ion-dependent adhesion site (MIDAS); other site 448385002480 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 448385002481 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 448385002482 TMP-binding site; other site 448385002483 ATP-binding site [chemical binding]; other site 448385002484 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 448385002485 pantoate--beta-alanine ligase; Region: panC; TIGR00018 448385002486 active site 448385002487 nucleotide binding site [chemical binding]; other site 448385002488 HIGH motif; other site 448385002489 KMSKS motif; other site 448385002490 polyphosphate kinase; Provisional; Region: PRK05443 448385002491 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 448385002492 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 448385002493 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 448385002494 putative domain interface [polypeptide binding]; other site 448385002495 putative active site [active] 448385002496 catalytic site [active] 448385002497 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 448385002498 putative domain interface [polypeptide binding]; other site 448385002499 putative active site [active] 448385002500 catalytic site [active] 448385002501 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 448385002502 S17 interaction site [polypeptide binding]; other site 448385002503 S8 interaction site; other site 448385002504 16S rRNA interaction site [nucleotide binding]; other site 448385002505 streptomycin interaction site [chemical binding]; other site 448385002506 23S rRNA interaction site [nucleotide binding]; other site 448385002507 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 448385002508 30S ribosomal protein S7; Validated; Region: PRK05302 448385002509 elongation factor G; Reviewed; Region: PRK00007 448385002510 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 448385002511 G1 box; other site 448385002512 putative GEF interaction site [polypeptide binding]; other site 448385002513 GTP/Mg2+ binding site [chemical binding]; other site 448385002514 Switch I region; other site 448385002515 G2 box; other site 448385002516 G3 box; other site 448385002517 Switch II region; other site 448385002518 G4 box; other site 448385002519 G5 box; other site 448385002520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 448385002521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 448385002522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 448385002523 elongation factor Tu; Reviewed; Region: PRK00049 448385002524 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 448385002525 G1 box; other site 448385002526 GEF interaction site [polypeptide binding]; other site 448385002527 GTP/Mg2+ binding site [chemical binding]; other site 448385002528 Switch I region; other site 448385002529 G2 box; other site 448385002530 G3 box; other site 448385002531 Switch II region; other site 448385002532 G4 box; other site 448385002533 G5 box; other site 448385002534 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 448385002535 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 448385002536 Antibiotic Binding Site [chemical binding]; other site 448385002537 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 448385002538 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 448385002539 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 448385002540 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 448385002541 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 448385002542 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 448385002543 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 448385002544 TPR repeat; Region: TPR_11; pfam13414 448385002545 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002546 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002547 active site 448385002548 ATP binding site [chemical binding]; other site 448385002549 substrate binding site [chemical binding]; other site 448385002550 activation loop (A-loop); other site 448385002551 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385002552 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002553 active site 448385002554 ATP binding site [chemical binding]; other site 448385002555 substrate binding site [chemical binding]; other site 448385002556 activation loop (A-loop); other site 448385002557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385002558 binding surface 448385002559 TPR motif; other site 448385002560 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385002561 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002562 active site 448385002563 ATP binding site [chemical binding]; other site 448385002564 substrate binding site [chemical binding]; other site 448385002565 activation loop (A-loop); other site 448385002566 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385002567 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385002568 active site 448385002569 oxyanion hole [active] 448385002570 catalytic triad [active] 448385002571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385002572 NAD(P) binding site [chemical binding]; other site 448385002573 active site 448385002574 3D domain; Region: 3D; cl01439 448385002575 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002577 active site 448385002578 ATP binding site [chemical binding]; other site 448385002579 substrate binding site [chemical binding]; other site 448385002580 activation loop (A-loop); other site 448385002581 HEAT repeats; Region: HEAT_2; pfam13646 448385002582 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 448385002583 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385002584 HSP70 interaction site [polypeptide binding]; other site 448385002585 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385002586 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385002587 TPR motif; other site 448385002588 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 448385002589 Active site serine [active] 448385002590 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 448385002591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385002592 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385002593 DNA binding residues [nucleotide binding] 448385002594 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 448385002595 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 448385002596 putative active site [active] 448385002597 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 448385002598 active site 448385002599 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 448385002600 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385002601 DXD motif; other site 448385002602 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 448385002603 Uncharacterized conserved protein [Function unknown]; Region: COG1434 448385002604 putative active site [active] 448385002605 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 448385002606 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385002607 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 448385002608 TatD related DNase; Region: TatD_DNase; pfam01026 448385002609 active site 448385002610 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 448385002611 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 448385002612 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 448385002613 UbiA prenyltransferase family; Region: UbiA; pfam01040 448385002614 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 448385002615 active site 448385002616 metal binding site [ion binding]; metal-binding site 448385002617 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 448385002618 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 448385002619 colanic acid exporter; Provisional; Region: PRK10459 448385002620 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 448385002621 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 448385002622 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 448385002623 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 448385002624 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 448385002625 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385002626 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385002627 phosphopeptide binding site; other site 448385002628 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385002629 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385002630 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 448385002631 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 448385002632 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 448385002633 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 448385002634 anti sigma factor interaction site; other site 448385002635 regulatory phosphorylation site [posttranslational modification]; other site 448385002636 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 448385002637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 448385002638 Bacterial sugar transferase; Region: Bac_transf; pfam02397 448385002639 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 448385002640 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385002641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385002642 NAD(P) binding site [chemical binding]; other site 448385002643 active site 448385002644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 448385002645 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385002646 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 448385002647 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 448385002648 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385002649 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 448385002650 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385002651 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 448385002652 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 448385002653 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385002654 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 448385002655 homodimer interface [polypeptide binding]; other site 448385002656 homotetramer interface [polypeptide binding]; other site 448385002657 active site pocket [active] 448385002658 cleavage site 448385002659 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 448385002660 Part of AAA domain; Region: AAA_19; pfam13245 448385002661 Family description; Region: UvrD_C_2; pfam13538 448385002662 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385002663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 448385002664 muropeptide transporter; Reviewed; Region: ampG; PRK11902 448385002665 muropeptide transporter; Validated; Region: ampG; cl17669 448385002666 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 448385002667 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 448385002668 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 448385002669 active site 448385002670 metal binding site [ion binding]; metal-binding site 448385002671 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 448385002672 Found in ATP-dependent protease La (LON); Region: LON; smart00464 448385002673 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385002674 Walker A motif; other site 448385002675 ATP binding site [chemical binding]; other site 448385002676 Walker B motif; other site 448385002677 arginine finger; other site 448385002678 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385002679 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 448385002680 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385002681 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 448385002682 nucleophilic elbow; other site 448385002683 catalytic triad; other site 448385002684 Domain of unknown function (DUF814); Region: DUF814; pfam05670 448385002685 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385002686 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 448385002687 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 448385002688 acyl-activating enzyme (AAE) consensus motif; other site 448385002689 putative AMP binding site [chemical binding]; other site 448385002690 putative active site [active] 448385002691 putative CoA binding site [chemical binding]; other site 448385002692 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 448385002693 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 448385002694 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 448385002695 catalytic triad [active] 448385002696 dimer interface [polypeptide binding]; other site 448385002697 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385002698 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 448385002699 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 448385002700 DNA binding site [nucleotide binding] 448385002701 active site 448385002702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385002703 endonuclease III; Region: ENDO3c; smart00478 448385002704 minor groove reading motif; other site 448385002705 helix-hairpin-helix signature motif; other site 448385002706 substrate binding pocket [chemical binding]; other site 448385002707 active site 448385002708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385002709 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385002710 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385002711 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385002712 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 448385002713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385002714 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385002715 DNA binding residues [nucleotide binding] 448385002716 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385002717 Zn2+ binding site [ion binding]; other site 448385002718 Mg2+ binding site [ion binding]; other site 448385002719 Caspase domain; Region: Peptidase_C14; pfam00656 448385002720 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385002721 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385002722 phosphopeptide binding site; other site 448385002723 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 448385002724 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385002725 Predicted amidohydrolase [General function prediction only]; Region: COG0388 448385002726 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 448385002727 active site 448385002728 catalytic triad [active] 448385002729 dimer interface [polypeptide binding]; other site 448385002730 TIR domain; Region: TIR_2; pfam13676 448385002731 Protein kinase domain; Region: Pkinase; pfam00069 448385002732 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002733 active site 448385002734 ATP binding site [chemical binding]; other site 448385002735 substrate binding site [chemical binding]; other site 448385002736 activation loop (A-loop); other site 448385002737 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385002738 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385002739 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 448385002740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385002741 motif II; other site 448385002742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385002743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385002744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385002745 dimerization interface [polypeptide binding]; other site 448385002746 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 448385002747 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 448385002748 G1 box; other site 448385002749 putative GEF interaction site [polypeptide binding]; other site 448385002750 GTP/Mg2+ binding site [chemical binding]; other site 448385002751 Switch I region; other site 448385002752 G2 box; other site 448385002753 G3 box; other site 448385002754 Switch II region; other site 448385002755 G4 box; other site 448385002756 G5 box; other site 448385002757 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 448385002758 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 448385002759 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 448385002760 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385002761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385002762 PAS domain; Region: PAS_9; pfam13426 448385002763 putative active site [active] 448385002764 heme pocket [chemical binding]; other site 448385002765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385002766 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385002767 putative active site [active] 448385002768 heme pocket [chemical binding]; other site 448385002769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002770 dimer interface [polypeptide binding]; other site 448385002771 phosphorylation site [posttranslational modification] 448385002772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002773 ATP binding site [chemical binding]; other site 448385002774 Mg2+ binding site [ion binding]; other site 448385002775 G-X-G motif; other site 448385002776 Response regulator receiver domain; Region: Response_reg; pfam00072 448385002777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385002778 active site 448385002779 phosphorylation site [posttranslational modification] 448385002780 intermolecular recognition site; other site 448385002781 dimerization interface [polypeptide binding]; other site 448385002782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002783 dimer interface [polypeptide binding]; other site 448385002784 phosphorylation site [posttranslational modification] 448385002785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002786 ATP binding site [chemical binding]; other site 448385002787 Mg2+ binding site [ion binding]; other site 448385002788 G-X-G motif; other site 448385002789 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002790 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002791 active site 448385002792 ATP binding site [chemical binding]; other site 448385002793 substrate binding site [chemical binding]; other site 448385002794 activation loop (A-loop); other site 448385002795 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 448385002796 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 448385002797 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 448385002798 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 448385002799 tetramerization interface [polypeptide binding]; other site 448385002800 active site 448385002801 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 448385002802 active site 448385002803 metal binding site [ion binding]; metal-binding site 448385002804 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 448385002805 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385002806 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 448385002807 active site 448385002808 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002810 active site 448385002811 ATP binding site [chemical binding]; other site 448385002812 substrate binding site [chemical binding]; other site 448385002813 activation loop (A-loop); other site 448385002814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385002815 binding surface 448385002816 TPR motif; other site 448385002817 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 448385002818 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385002819 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385002820 catalytic residue [active] 448385002821 Cytochrome c; Region: Cytochrom_C; cl11414 448385002822 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 448385002823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002825 dimer interface [polypeptide binding]; other site 448385002826 phosphorylation site [posttranslational modification] 448385002827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002828 ATP binding site [chemical binding]; other site 448385002829 Mg2+ binding site [ion binding]; other site 448385002830 G-X-G motif; other site 448385002831 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 448385002832 hydrophobic ligand binding site; other site 448385002833 SprT homologues; Region: SprT; cl01182 448385002834 SprT-like family; Region: SprT-like; pfam10263 448385002835 Sulfatase; Region: Sulfatase; cl17466 448385002836 Sulfatase; Region: Sulfatase; cl17466 448385002837 Predicted ATPase [General function prediction only]; Region: COG4637 448385002838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385002839 Walker A/P-loop; other site 448385002840 ATP binding site [chemical binding]; other site 448385002841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385002842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385002843 LysR substrate binding domain; Region: LysR_substrate; pfam03466 448385002844 dimerization interface [polypeptide binding]; other site 448385002845 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 448385002846 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 448385002847 potential catalytic triad [active] 448385002848 conserved cys residue [active] 448385002849 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385002850 putative active site [active] 448385002851 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 448385002852 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 448385002853 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385002854 putative lipid kinase; Reviewed; Region: PRK00861 448385002855 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 448385002856 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385002857 active site 448385002858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385002859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385002860 dimer interface [polypeptide binding]; other site 448385002861 phosphorylation site [posttranslational modification] 448385002862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385002863 ATP binding site [chemical binding]; other site 448385002864 Mg2+ binding site [ion binding]; other site 448385002865 G-X-G motif; other site 448385002866 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 448385002867 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 448385002868 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 448385002869 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 448385002870 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 448385002871 active site 448385002872 catalytic residues [active] 448385002873 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385002874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385002875 active site 448385002876 metal binding site [ion binding]; metal-binding site 448385002877 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385002878 dinuclear metal binding motif [ion binding]; other site 448385002879 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 448385002880 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 448385002881 Bacterial PH domain; Region: DUF304; pfam03703 448385002882 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385002883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385002884 binding surface 448385002885 TPR motif; other site 448385002886 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 448385002887 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 448385002888 NAD(P) binding site [chemical binding]; other site 448385002889 substrate binding site [chemical binding]; other site 448385002890 homotetramer interface [polypeptide binding]; other site 448385002891 active site 448385002892 homodimer interface [polypeptide binding]; other site 448385002893 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 448385002894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385002895 active site 448385002896 metal binding site [ion binding]; metal-binding site 448385002897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385002898 DNA-binding site [nucleotide binding]; DNA binding site 448385002899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385002900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385002901 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 448385002902 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385002903 hypothetical protein; Provisional; Region: PRK07588 448385002904 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 448385002905 active site 448385002906 catalytic site [active] 448385002907 substrate binding site [chemical binding]; other site 448385002908 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385002909 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 448385002910 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 448385002911 classical (c) SDRs; Region: SDR_c; cd05233 448385002912 NAD(P) binding site [chemical binding]; other site 448385002913 active site 448385002914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385002915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385002916 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385002917 dimerization interface [polypeptide binding]; other site 448385002918 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385002919 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385002920 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385002921 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385002922 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385002923 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385002924 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 448385002925 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 448385002926 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 448385002927 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385002928 Methyltransferase domain; Region: Methyltransf_11; pfam08241 448385002929 CBD_II domain; Region: CBD_II; smart00637 448385002930 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 448385002931 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 448385002932 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385002933 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385002934 Walker A/P-loop; other site 448385002935 ATP binding site [chemical binding]; other site 448385002936 Q-loop/lid; other site 448385002937 ABC transporter signature motif; other site 448385002938 Walker B; other site 448385002939 D-loop; other site 448385002940 H-loop/switch region; other site 448385002941 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385002942 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385002943 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385002944 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385002945 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385002946 FtsX-like permease family; Region: FtsX; pfam02687 448385002947 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385002948 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385002949 FtsX-like permease family; Region: FtsX; pfam02687 448385002950 photoactive yellow protein; Region: photo_yellow; TIGR02373 448385002951 putative transporter; Validated; Region: PRK03818 448385002952 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 448385002953 TrkA-C domain; Region: TrkA_C; pfam02080 448385002954 TrkA-C domain; Region: TrkA_C; pfam02080 448385002955 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 448385002956 enterobactin exporter EntS; Provisional; Region: PRK10489 448385002957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385002958 putative substrate translocation pore; other site 448385002959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 448385002960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385002961 Coenzyme A binding pocket [chemical binding]; other site 448385002962 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 448385002963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385002964 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385002965 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385002966 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385002967 TAP-like protein; Region: Abhydrolase_4; pfam08386 448385002968 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002970 active site 448385002971 ATP binding site [chemical binding]; other site 448385002972 substrate binding site [chemical binding]; other site 448385002973 activation loop (A-loop); other site 448385002974 PEGA domain; Region: PEGA; pfam08308 448385002975 PEGA domain; Region: PEGA; pfam08308 448385002976 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 448385002977 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385002978 metal ion-dependent adhesion site (MIDAS); other site 448385002979 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385002980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002981 active site 448385002982 ATP binding site [chemical binding]; other site 448385002983 substrate binding site [chemical binding]; other site 448385002984 activation loop (A-loop); other site 448385002985 PEGA domain; Region: PEGA; pfam08308 448385002986 PEGA domain; Region: PEGA; pfam08308 448385002987 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385002988 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385002989 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385002990 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385002991 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385002992 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385002993 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 448385002994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385002995 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385002996 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385002997 active site 448385002998 ATP binding site [chemical binding]; other site 448385002999 substrate binding site [chemical binding]; other site 448385003000 activation loop (A-loop); other site 448385003001 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 448385003002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385003003 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 448385003004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003005 putative ADP-binding pocket [chemical binding]; other site 448385003006 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 448385003007 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 448385003008 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 448385003009 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003010 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 448385003011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385003012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385003013 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 448385003014 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 448385003015 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385003016 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 448385003017 active site 448385003018 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 448385003019 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385003020 putative acyl-acceptor binding pocket; other site 448385003021 putative glycosyl transferase; Provisional; Region: PRK10307 448385003022 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 448385003023 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385003024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385003025 NAD(P) binding site [chemical binding]; other site 448385003026 active site 448385003027 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385003028 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003029 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385003030 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385003031 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 448385003032 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 448385003033 RNA/DNA hybrid binding site [nucleotide binding]; other site 448385003034 active site 448385003035 SurA N-terminal domain; Region: SurA_N; pfam09312 448385003036 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 448385003037 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003038 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003039 active site 448385003040 ATP binding site [chemical binding]; other site 448385003041 substrate binding site [chemical binding]; other site 448385003042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385003043 substrate binding site [chemical binding]; other site 448385003044 activation loop (A-loop); other site 448385003045 activation loop (A-loop); other site 448385003046 PEGA domain; Region: PEGA; pfam08308 448385003047 phosphoglyceromutase; Provisional; Region: PRK05434 448385003048 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 448385003049 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385003050 putative active site [active] 448385003051 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385003052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 448385003053 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385003054 Coenzyme A binding pocket [chemical binding]; other site 448385003055 malate dehydrogenase; Reviewed; Region: PRK06223 448385003056 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 448385003057 NAD(P) binding site [chemical binding]; other site 448385003058 dimer interface [polypeptide binding]; other site 448385003059 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385003060 substrate binding site [chemical binding]; other site 448385003061 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 448385003062 ATP binding site [chemical binding]; other site 448385003063 active site 448385003064 substrate binding site [chemical binding]; other site 448385003065 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 448385003066 HEAT repeats; Region: HEAT_2; pfam13646 448385003067 AAA domain; Region: AAA_21; pfam13304 448385003068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385003069 Q-loop/lid; other site 448385003070 ABC transporter signature motif; other site 448385003071 Walker B; other site 448385003072 D-loop; other site 448385003073 H-loop/switch region; other site 448385003074 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 448385003075 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 448385003076 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385003077 substrate binding site [chemical binding]; other site 448385003078 oxyanion hole (OAH) forming residues; other site 448385003079 trimer interface [polypeptide binding]; other site 448385003080 Shikimate kinase; Region: SKI; pfam01202 448385003081 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 448385003082 ADP binding site [chemical binding]; other site 448385003083 magnesium binding site [ion binding]; other site 448385003084 putative shikimate binding site; other site 448385003085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003086 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 448385003087 homodimer interface [polypeptide binding]; other site 448385003088 ADP-binding pocket [chemical binding]; other site 448385003089 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 448385003090 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 448385003091 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 448385003092 Walker A/P-loop; other site 448385003093 ATP binding site [chemical binding]; other site 448385003094 Q-loop/lid; other site 448385003095 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 448385003096 ABC transporter signature motif; other site 448385003097 Walker B; other site 448385003098 D-loop; other site 448385003099 H-loop/switch region; other site 448385003100 Thymidylate synthase complementing protein; Region: Thy1; cl03630 448385003101 Thymidylate synthase complementing protein; Region: Thy1; cl03630 448385003102 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 448385003103 active site 448385003104 NifU-like domain; Region: NifU; cl00484 448385003105 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 448385003106 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 448385003107 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385003108 Ligand Binding Site [chemical binding]; other site 448385003109 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 448385003110 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003111 Protein kinase domain; Region: Pkinase; pfam00069 448385003112 active site 448385003113 ATP binding site [chemical binding]; other site 448385003114 substrate binding site [chemical binding]; other site 448385003115 activation loop (A-loop); other site 448385003116 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385003117 Domain of unknown function (DUF362); Region: DUF362; pfam04015 448385003118 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 448385003119 4Fe-4S binding domain; Region: Fer4_5; pfam12801 448385003120 4Fe-4S binding domain; Region: Fer4_5; pfam12801 448385003121 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 448385003122 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 448385003123 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 448385003124 4Fe-4S binding domain; Region: Fer4; pfam00037 448385003125 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 448385003126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385003127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385003128 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 448385003129 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385003130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003131 active site 448385003132 ATP binding site [chemical binding]; other site 448385003133 substrate binding site [chemical binding]; other site 448385003134 activation loop (A-loop); other site 448385003135 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 448385003136 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 448385003137 active site 448385003138 NTP binding site [chemical binding]; other site 448385003139 metal binding triad [ion binding]; metal-binding site 448385003140 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 448385003141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385003142 Zn2+ binding site [ion binding]; other site 448385003143 Mg2+ binding site [ion binding]; other site 448385003144 guanine deaminase; Provisional; Region: PRK09228 448385003145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385003146 active site 448385003147 Bacterial SH3 domain; Region: SH3_3; cl17532 448385003148 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385003149 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385003150 Sulfatase; Region: Sulfatase; pfam00884 448385003151 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385003152 putative active site [active] 448385003153 LVIVD repeat; Region: LVIVD; pfam08309 448385003154 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 448385003155 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385003156 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385003157 catalytic residues [active] 448385003158 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 448385003159 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 448385003160 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 448385003161 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 448385003162 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 448385003163 active site 448385003164 ribulose/triose binding site [chemical binding]; other site 448385003165 phosphate binding site [ion binding]; other site 448385003166 substrate (anthranilate) binding pocket [chemical binding]; other site 448385003167 product (indole) binding pocket [chemical binding]; other site 448385003168 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 448385003169 active site 448385003170 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 448385003171 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 448385003172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385003173 catalytic residue [active] 448385003174 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 448385003175 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 448385003176 substrate binding site [chemical binding]; other site 448385003177 active site 448385003178 catalytic residues [active] 448385003179 heterodimer interface [polypeptide binding]; other site 448385003180 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385003181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385003182 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385003183 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 448385003184 Family of unknown function (DUF490); Region: DUF490; pfam04357 448385003185 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 448385003186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385003187 Walker A/P-loop; other site 448385003188 ATP binding site [chemical binding]; other site 448385003189 Q-loop/lid; other site 448385003190 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385003191 ABC transporter; Region: ABC_tran_2; pfam12848 448385003192 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385003193 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 448385003194 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385003195 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385003196 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385003197 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 448385003198 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385003199 FtsX-like permease family; Region: FtsX; pfam02687 448385003200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385003201 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385003202 Walker A/P-loop; other site 448385003203 ATP binding site [chemical binding]; other site 448385003204 Q-loop/lid; other site 448385003205 ABC transporter signature motif; other site 448385003206 Walker B; other site 448385003207 D-loop; other site 448385003208 H-loop/switch region; other site 448385003209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385003210 S-adenosylmethionine binding site [chemical binding]; other site 448385003211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385003212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385003213 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 448385003214 dimerization interface [polypeptide binding]; other site 448385003215 substrate binding pocket [chemical binding]; other site 448385003216 Predicted membrane protein [Function unknown]; Region: COG2323 448385003217 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 448385003218 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 448385003219 putative NAD(P) binding site [chemical binding]; other site 448385003220 putative substrate binding site [chemical binding]; other site 448385003221 catalytic Zn binding site [ion binding]; other site 448385003222 structural Zn binding site [ion binding]; other site 448385003223 dimer interface [polypeptide binding]; other site 448385003224 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385003225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385003226 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 448385003227 putative substrate binding pocket [chemical binding]; other site 448385003228 putative dimerization interface [polypeptide binding]; other site 448385003229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385003230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 448385003231 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385003232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385003233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385003234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385003235 dimerization interface [polypeptide binding]; other site 448385003236 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 448385003237 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385003238 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385003239 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 448385003240 C-terminal domain interface [polypeptide binding]; other site 448385003241 GSH binding site (G-site) [chemical binding]; other site 448385003242 dimer interface [polypeptide binding]; other site 448385003243 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 448385003244 N-terminal domain interface [polypeptide binding]; other site 448385003245 dimer interface [polypeptide binding]; other site 448385003246 substrate binding pocket (H-site) [chemical binding]; other site 448385003247 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385003248 putative hydrophobic ligand binding site [chemical binding]; other site 448385003249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385003250 dimerization interface [polypeptide binding]; other site 448385003251 putative DNA binding site [nucleotide binding]; other site 448385003252 putative Zn2+ binding site [ion binding]; other site 448385003253 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 448385003254 putative hydrophobic ligand binding site [chemical binding]; other site 448385003255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385003256 dimerization interface [polypeptide binding]; other site 448385003257 putative DNA binding site [nucleotide binding]; other site 448385003258 putative Zn2+ binding site [ion binding]; other site 448385003259 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 448385003260 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 448385003261 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 448385003262 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 448385003263 metal binding site 2 [ion binding]; metal-binding site 448385003264 putative DNA binding helix; other site 448385003265 metal binding site 1 [ion binding]; metal-binding site 448385003266 dimer interface [polypeptide binding]; other site 448385003267 structural Zn2+ binding site [ion binding]; other site 448385003268 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 448385003269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385003270 Walker A/P-loop; other site 448385003271 ATP binding site [chemical binding]; other site 448385003272 Q-loop/lid; other site 448385003273 ABC transporter signature motif; other site 448385003274 Walker B; other site 448385003275 D-loop; other site 448385003276 H-loop/switch region; other site 448385003277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 448385003278 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 448385003279 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 448385003280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385003281 sequence-specific DNA binding site [nucleotide binding]; other site 448385003282 salt bridge; other site 448385003283 PBP superfamily domain; Region: PBP_like; pfam12727 448385003284 CHASE3 domain; Region: CHASE3; pfam05227 448385003285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003287 dimer interface [polypeptide binding]; other site 448385003288 phosphorylation site [posttranslational modification] 448385003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003290 ATP binding site [chemical binding]; other site 448385003291 Mg2+ binding site [ion binding]; other site 448385003292 G-X-G motif; other site 448385003293 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385003294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385003295 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 448385003296 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 448385003297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385003298 DNA-binding site [nucleotide binding]; DNA binding site 448385003299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385003300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385003301 homodimer interface [polypeptide binding]; other site 448385003302 catalytic residue [active] 448385003303 short chain dehydrogenase; Provisional; Region: PRK06123 448385003304 classical (c) SDRs; Region: SDR_c; cd05233 448385003305 NAD(P) binding site [chemical binding]; other site 448385003306 active site 448385003307 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 448385003308 putative pectinesterase; Region: PLN02432; cl01911 448385003309 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 448385003310 RNAase interaction site [polypeptide binding]; other site 448385003311 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 448385003312 Asp-box motif; other site 448385003313 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 448385003314 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 448385003315 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 448385003316 [4Fe-4S] binding site [ion binding]; other site 448385003317 molybdopterin cofactor binding site; other site 448385003318 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 448385003319 molybdopterin cofactor binding site; other site 448385003320 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 448385003321 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385003322 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385003323 Flagellin N-methylase; Region: FliB; cl00497 448385003324 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_13; cd13141 448385003325 putative efflux protein, MATE family; Region: matE; TIGR00797 448385003326 hypothetical protein; Provisional; Region: PRK08204 448385003327 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385003328 active site 448385003329 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 448385003330 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 448385003331 active site 448385003332 DNA binding site [nucleotide binding] 448385003333 Int/Topo IB signature motif; other site 448385003334 catalytic residues [active] 448385003335 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 448385003336 dinuclear metal binding motif [ion binding]; other site 448385003337 Putative addiction module component; Region: Unstab_antitox; cl09921 448385003338 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385003339 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 448385003340 FAD binding site [chemical binding]; other site 448385003341 homotetramer interface [polypeptide binding]; other site 448385003342 substrate binding pocket [chemical binding]; other site 448385003343 catalytic base [active] 448385003344 Methyltransferase domain; Region: Methyltransf_12; pfam08242 448385003345 S-adenosylmethionine binding site [chemical binding]; other site 448385003346 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 448385003347 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 448385003348 putative active site [active] 448385003349 metal binding site [ion binding]; metal-binding site 448385003350 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 448385003351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385003352 PAS fold; Region: PAS_3; pfam08447 448385003353 putative active site [active] 448385003354 heme pocket [chemical binding]; other site 448385003355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 448385003356 dimer interface [polypeptide binding]; other site 448385003357 phosphorylation site [posttranslational modification] 448385003358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003359 ATP binding site [chemical binding]; other site 448385003360 Mg2+ binding site [ion binding]; other site 448385003361 G-X-G motif; other site 448385003362 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 448385003363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003364 active site 448385003365 phosphorylation site [posttranslational modification] 448385003366 intermolecular recognition site; other site 448385003367 dimerization interface [polypeptide binding]; other site 448385003368 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 448385003369 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385003370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385003371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385003372 Walker A/P-loop; other site 448385003373 ATP binding site [chemical binding]; other site 448385003374 Q-loop/lid; other site 448385003375 ABC transporter signature motif; other site 448385003376 Walker B; other site 448385003377 D-loop; other site 448385003378 H-loop/switch region; other site 448385003379 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 448385003380 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003382 active site 448385003383 phosphorylation site [posttranslational modification] 448385003384 intermolecular recognition site; other site 448385003385 dimerization interface [polypeptide binding]; other site 448385003386 PhoD-like phosphatase; Region: PhoD; pfam09423 448385003387 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 448385003388 putative active site [active] 448385003389 putative metal binding site [ion binding]; other site 448385003390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385003391 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385003392 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385003393 Multicopper oxidase; Region: Cu-oxidase; pfam00394 448385003394 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385003395 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385003396 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385003397 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385003398 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 448385003399 dimer interface [polypeptide binding]; other site 448385003400 N-terminal domain interface [polypeptide binding]; other site 448385003401 substrate binding pocket (H-site) [chemical binding]; other site 448385003402 GAF domain; Region: GAF; pfam01590 448385003403 PAS domain; Region: PAS; smart00091 448385003404 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385003405 putative active site [active] 448385003406 heme pocket [chemical binding]; other site 448385003407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003408 dimer interface [polypeptide binding]; other site 448385003409 phosphorylation site [posttranslational modification] 448385003410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003411 ATP binding site [chemical binding]; other site 448385003412 Mg2+ binding site [ion binding]; other site 448385003413 G-X-G motif; other site 448385003414 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003416 active site 448385003417 phosphorylation site [posttranslational modification] 448385003418 intermolecular recognition site; other site 448385003419 dimerization interface [polypeptide binding]; other site 448385003420 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385003421 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385003422 Predicted esterase [General function prediction only]; Region: COG0400 448385003423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385003424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385003425 active site 448385003426 catalytic tetrad [active] 448385003427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385003428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385003429 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 448385003430 putative substrate binding pocket [chemical binding]; other site 448385003431 putative dimerization interface [polypeptide binding]; other site 448385003432 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 448385003433 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 448385003434 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385003435 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385003436 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 448385003437 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385003438 active site 448385003439 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385003440 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385003441 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385003442 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385003443 conserved hypothetical protein; Region: TIGR02270 448385003444 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385003445 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385003446 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003448 active site 448385003449 ATP binding site [chemical binding]; other site 448385003450 substrate binding site [chemical binding]; other site 448385003451 activation loop (A-loop); other site 448385003452 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385003453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385003454 metal ion-dependent adhesion site (MIDAS); other site 448385003455 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385003456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385003457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385003458 catalytic residue [active] 448385003459 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 448385003460 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 448385003461 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 448385003462 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 448385003463 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385003464 active site 448385003465 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 448385003466 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 448385003467 PYR/PP interface [polypeptide binding]; other site 448385003468 dimer interface [polypeptide binding]; other site 448385003469 TPP binding site [chemical binding]; other site 448385003470 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 448385003471 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 448385003472 TPP-binding site [chemical binding]; other site 448385003473 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 448385003474 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385003475 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385003476 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 448385003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385003478 S-adenosylmethionine binding site [chemical binding]; other site 448385003479 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 448385003480 metal binding site [ion binding]; metal-binding site 448385003481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385003482 NADH(P)-binding; Region: NAD_binding_10; pfam13460 448385003483 NAD(P) binding site [chemical binding]; other site 448385003484 active site 448385003485 Cupin; Region: Cupin_6; pfam12852 448385003486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385003487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385003488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385003489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385003490 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385003491 putative substrate translocation pore; other site 448385003492 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 448385003493 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385003494 putative binding surface; other site 448385003495 active site 448385003496 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 448385003497 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 448385003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003499 ATP binding site [chemical binding]; other site 448385003500 Mg2+ binding site [ion binding]; other site 448385003501 G-X-G motif; other site 448385003502 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 448385003503 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 448385003504 CHASE3 domain; Region: CHASE3; pfam05227 448385003505 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 448385003506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385003507 dimerization interface [polypeptide binding]; other site 448385003508 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 448385003509 dimer interface [polypeptide binding]; other site 448385003510 putative CheW interface [polypeptide binding]; other site 448385003511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385003512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385003513 hypothetical protein; Provisional; Region: PRK06834 448385003514 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385003515 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 448385003516 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 448385003517 active site 448385003518 metal binding site [ion binding]; metal-binding site 448385003519 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 448385003520 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 448385003521 Family description; Region: VCBS; pfam13517 448385003522 Family description; Region: VCBS; pfam13517 448385003523 Family description; Region: VCBS; pfam13517 448385003524 Family description; Region: VCBS; pfam13517 448385003525 Family description; Region: VCBS; pfam13517 448385003526 Family description; Region: VCBS; pfam13517 448385003527 Family description; Region: VCBS; pfam13517 448385003528 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 448385003529 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385003530 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385003531 Lamin Tail Domain; Region: LTD; pfam00932 448385003532 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 448385003533 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 448385003534 active site 448385003535 intersubunit interface [polypeptide binding]; other site 448385003536 catalytic residue [active] 448385003537 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 448385003538 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 448385003539 substrate binding site [chemical binding]; other site 448385003540 ATP binding site [chemical binding]; other site 448385003541 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 448385003542 Amidohydrolase; Region: Amidohydro_2; pfam04909 448385003543 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 448385003544 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385003545 putative NAD(P) binding site [chemical binding]; other site 448385003546 catalytic Zn binding site [ion binding]; other site 448385003547 structural Zn binding site [ion binding]; other site 448385003548 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 448385003549 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 448385003550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385003551 D-galactonate transporter; Region: 2A0114; TIGR00893 448385003552 putative substrate translocation pore; other site 448385003553 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 448385003554 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 448385003555 Calx-beta domain; Region: Calx-beta; cl02522 448385003556 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 448385003557 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 448385003558 active site 448385003559 Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; Region: TNFR; cl12111 448385003560 protein binding site [polypeptide binding]; other site 448385003561 parallel homodimerization interface [polypeptide binding]; other site 448385003562 antiparallel homodimerization interface [polypeptide binding]; other site 448385003563 50's loop TNF binding site; other site 448385003564 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385003565 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385003566 active site 448385003567 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 448385003568 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385003569 N-terminal domain interface [polypeptide binding]; other site 448385003570 dimer interface [polypeptide binding]; other site 448385003571 substrate binding pocket (H-site) [chemical binding]; other site 448385003572 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 448385003573 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 448385003574 active site 448385003575 Zn binding site [ion binding]; other site 448385003576 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 448385003577 Protein of unknown function (DUF877); Region: DUF877; pfam05943 448385003578 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 448385003579 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385003580 Soluble P-type ATPase [General function prediction only]; Region: COG4087 448385003581 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003582 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385003583 active site 448385003584 ATP binding site [chemical binding]; other site 448385003585 substrate binding site [chemical binding]; other site 448385003586 activation loop (A-loop); other site 448385003587 Predicted ATPase [General function prediction only]; Region: COG3899 448385003588 AAA ATPase domain; Region: AAA_16; pfam13191 448385003589 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385003590 GAF domain; Region: GAF_3; pfam13492 448385003591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003592 dimer interface [polypeptide binding]; other site 448385003593 phosphorylation site [posttranslational modification] 448385003594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003595 ATP binding site [chemical binding]; other site 448385003596 Mg2+ binding site [ion binding]; other site 448385003597 G-X-G motif; other site 448385003598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003600 active site 448385003601 ATP binding site [chemical binding]; other site 448385003602 substrate binding site [chemical binding]; other site 448385003603 activation loop (A-loop); other site 448385003604 arogenate dehydrogenase; Region: PLN02256 448385003605 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 448385003606 Chorismate mutase type II; Region: CM_2; smart00830 448385003607 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003609 active site 448385003610 phosphorylation site [posttranslational modification] 448385003611 intermolecular recognition site; other site 448385003612 dimerization interface [polypeptide binding]; other site 448385003613 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385003614 GAF domain; Region: GAF; pfam01590 448385003615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385003616 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003617 dimer interface [polypeptide binding]; other site 448385003618 phosphorylation site [posttranslational modification] 448385003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003620 ATP binding site [chemical binding]; other site 448385003621 Mg2+ binding site [ion binding]; other site 448385003622 G-X-G motif; other site 448385003623 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003625 active site 448385003626 phosphorylation site [posttranslational modification] 448385003627 intermolecular recognition site; other site 448385003628 dimerization interface [polypeptide binding]; other site 448385003629 Predicted ATPase [General function prediction only]; Region: COG3899 448385003630 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385003631 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385003632 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 448385003633 ATP-binding site [chemical binding]; other site 448385003634 Gluconate-6-phosphate binding site [chemical binding]; other site 448385003635 Shikimate kinase; Region: SKI; pfam01202 448385003636 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385003637 reactive center loop; other site 448385003638 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 448385003639 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 448385003640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385003641 DNA-binding site [nucleotide binding]; DNA binding site 448385003642 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385003643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385003644 homodimer interface [polypeptide binding]; other site 448385003645 catalytic residue [active] 448385003646 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 448385003647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385003648 Coenzyme A binding pocket [chemical binding]; other site 448385003649 HIRAN domain; Region: HIRAN; cl07418 448385003650 HipA-like C-terminal domain; Region: HipA_C; pfam07804 448385003651 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385003652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385003653 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 448385003654 elongation factor G; Reviewed; Region: PRK12740 448385003655 G1 box; other site 448385003656 putative GEF interaction site [polypeptide binding]; other site 448385003657 GTP/Mg2+ binding site [chemical binding]; other site 448385003658 Switch I region; other site 448385003659 G2 box; other site 448385003660 G3 box; other site 448385003661 Switch II region; other site 448385003662 G4 box; other site 448385003663 G5 box; other site 448385003664 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 448385003665 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 448385003666 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 448385003667 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003668 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003669 active site 448385003670 ATP binding site [chemical binding]; other site 448385003671 substrate binding site [chemical binding]; other site 448385003672 activation loop (A-loop); other site 448385003673 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 448385003674 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 448385003675 SIR2-like domain; Region: SIR2_2; pfam13289 448385003676 Restriction endonuclease; Region: Mrr_cat; pfam04471 448385003677 Domain of unknown function (DUF955); Region: DUF955; pfam06114 448385003678 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385003679 active site 448385003680 Int/Topo IB signature motif; other site 448385003681 DNA binding site [nucleotide binding] 448385003682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385003683 active site 448385003684 Int/Topo IB signature motif; other site 448385003685 DNA binding site [nucleotide binding] 448385003686 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385003687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385003688 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385003689 substrate binding site [chemical binding]; other site 448385003690 activation loop (A-loop); other site 448385003691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385003692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003693 dimer interface [polypeptide binding]; other site 448385003694 phosphorylation site [posttranslational modification] 448385003695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003696 ATP binding site [chemical binding]; other site 448385003697 Mg2+ binding site [ion binding]; other site 448385003698 G-X-G motif; other site 448385003699 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 448385003700 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 448385003701 Metal-binding active site; metal-binding site 448385003702 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 448385003703 active site 448385003704 NTP binding site [chemical binding]; other site 448385003705 metal binding triad [ion binding]; metal-binding site 448385003706 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003707 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385003708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385003709 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 448385003710 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 448385003711 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 448385003712 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 448385003713 active site 448385003714 catalytic site [active] 448385003715 hypothetical protein; Provisional; Region: PRK01346 448385003716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385003717 Coenzyme A binding pocket [chemical binding]; other site 448385003718 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003719 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003720 active site 448385003721 ATP binding site [chemical binding]; other site 448385003722 substrate binding site [chemical binding]; other site 448385003723 activation loop (A-loop); other site 448385003724 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 448385003725 iron-sulfur cluster [ion binding]; other site 448385003726 [2Fe-2S] cluster binding site [ion binding]; other site 448385003727 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 448385003728 hypothetical protein; Reviewed; Region: PRK09588 448385003729 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 448385003730 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 448385003731 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 448385003732 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 448385003733 active site 1 [active] 448385003734 dimer interface [polypeptide binding]; other site 448385003735 hexamer interface [polypeptide binding]; other site 448385003736 active site 2 [active] 448385003737 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 448385003738 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 448385003739 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 448385003740 active site 448385003741 non-prolyl cis peptide bond; other site 448385003742 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 448385003743 active site clefts [active] 448385003744 zinc binding site [ion binding]; other site 448385003745 dimer interface [polypeptide binding]; other site 448385003746 Phosphotransferase enzyme family; Region: APH; pfam01636 448385003747 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 448385003748 active site 448385003749 ATP binding site [chemical binding]; other site 448385003750 substrate binding site [chemical binding]; other site 448385003751 dimer interface [polypeptide binding]; other site 448385003752 PAS domain S-box; Region: sensory_box; TIGR00229 448385003753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385003754 putative active site [active] 448385003755 heme pocket [chemical binding]; other site 448385003756 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385003757 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385003758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385003759 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385003760 membrane-bound complex binding site; other site 448385003761 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385003762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385003763 dimer interface [polypeptide binding]; other site 448385003764 conserved gate region; other site 448385003765 putative PBP binding loops; other site 448385003766 ABC-ATPase subunit interface; other site 448385003767 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385003769 putative PBP binding loops; other site 448385003770 ABC-ATPase subunit interface; other site 448385003771 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385003772 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385003773 Walker A/P-loop; other site 448385003774 ATP binding site [chemical binding]; other site 448385003775 Q-loop/lid; other site 448385003776 ABC transporter signature motif; other site 448385003777 Walker B; other site 448385003778 D-loop; other site 448385003779 H-loop/switch region; other site 448385003780 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385003781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385003782 Walker A motif; other site 448385003783 ATP binding site [chemical binding]; other site 448385003784 Walker B motif; other site 448385003785 arginine finger; other site 448385003786 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385003787 thioredoxin 2; Provisional; Region: PRK10996 448385003788 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385003789 catalytic residues [active] 448385003790 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 448385003791 putative hydrophobic ligand binding site [chemical binding]; other site 448385003792 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 448385003793 active site 448385003794 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385003795 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385003796 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385003797 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385003798 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385003799 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385003800 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 448385003801 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 448385003802 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 448385003803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385003804 NAD(P) binding site [chemical binding]; other site 448385003805 active site 448385003806 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385003807 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 448385003808 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 448385003809 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385003810 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385003811 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385003812 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385003813 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385003814 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385003815 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 448385003816 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385003817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385003818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385003819 DNA binding residues [nucleotide binding] 448385003820 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003822 active site 448385003823 phosphorylation site [posttranslational modification] 448385003824 intermolecular recognition site; other site 448385003825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385003826 HAMP domain; Region: HAMP; pfam00672 448385003827 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003828 dimer interface [polypeptide binding]; other site 448385003829 phosphorylation site [posttranslational modification] 448385003830 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003831 ATP binding site [chemical binding]; other site 448385003832 Mg2+ binding site [ion binding]; other site 448385003833 G-X-G motif; other site 448385003834 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385003835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003836 active site 448385003837 phosphorylation site [posttranslational modification] 448385003838 intermolecular recognition site; other site 448385003839 dimerization interface [polypeptide binding]; other site 448385003840 Response regulator receiver domain; Region: Response_reg; pfam00072 448385003841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003842 active site 448385003843 phosphorylation site [posttranslational modification] 448385003844 intermolecular recognition site; other site 448385003845 dimerization interface [polypeptide binding]; other site 448385003846 Hpt domain; Region: Hpt; pfam01627 448385003847 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385003848 TonB dependent receptor; Region: TonB_dep_Rec; pfam00593 448385003849 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 448385003850 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 448385003851 ligand binding site [chemical binding]; other site 448385003852 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 448385003853 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 448385003854 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385003855 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 448385003856 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 448385003857 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 448385003858 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 448385003859 Ligand Binding Site [chemical binding]; other site 448385003860 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 448385003861 GAF domain; Region: GAF_3; pfam13492 448385003862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003863 dimer interface [polypeptide binding]; other site 448385003864 phosphorylation site [posttranslational modification] 448385003865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003866 ATP binding site [chemical binding]; other site 448385003867 Mg2+ binding site [ion binding]; other site 448385003868 G-X-G motif; other site 448385003869 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 448385003870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003871 active site 448385003872 phosphorylation site [posttranslational modification] 448385003873 intermolecular recognition site; other site 448385003874 dimerization interface [polypeptide binding]; other site 448385003875 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385003876 DNA binding site [nucleotide binding] 448385003877 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385003878 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385003879 Family description; Region: VCBS; pfam13517 448385003880 Family description; Region: VCBS; pfam13517 448385003881 Family description; Region: VCBS; pfam13517 448385003882 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 448385003883 active site 448385003884 DNA polymerase IV; Validated; Region: PRK02406 448385003885 DNA binding site [nucleotide binding] 448385003886 DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874 448385003887 PQQ-like domain; Region: PQQ_2; pfam13360 448385003888 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385003889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385003890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385003891 RibD C-terminal domain; Region: RibD_C; cl17279 448385003892 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 448385003893 Protein of unknown function (DUF808); Region: DUF808; pfam05661 448385003894 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 448385003895 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 448385003896 GTP/Mg2+ binding site [chemical binding]; other site 448385003897 G4 box; other site 448385003898 G5 box; other site 448385003899 G1 box; other site 448385003900 Switch I region; other site 448385003901 G2 box; other site 448385003902 G3 box; other site 448385003903 Switch II region; other site 448385003904 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 448385003905 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 448385003906 catalytic residues [active] 448385003907 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385003908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385003909 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 448385003910 Protein kinase domain; Region: Pkinase; pfam00069 448385003911 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385003912 active site 448385003913 ATP binding site [chemical binding]; other site 448385003914 substrate binding site [chemical binding]; other site 448385003915 activation loop (A-loop); other site 448385003916 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385003917 putative catalytic site [active] 448385003918 putative metal binding site [ion binding]; other site 448385003919 putative phosphate binding site [ion binding]; other site 448385003920 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 448385003921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385003922 Coenzyme A binding pocket [chemical binding]; other site 448385003923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385003924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385003925 dimer interface [polypeptide binding]; other site 448385003926 phosphorylation site [posttranslational modification] 448385003927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003928 ATP binding site [chemical binding]; other site 448385003929 Mg2+ binding site [ion binding]; other site 448385003930 G-X-G motif; other site 448385003931 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 448385003932 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 448385003933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385003934 maltose O-acetyltransferase; Provisional; Region: PRK10092 448385003935 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 448385003936 active site 448385003937 substrate binding site [chemical binding]; other site 448385003938 trimer interface [polypeptide binding]; other site 448385003939 CoA binding site [chemical binding]; other site 448385003940 AbgT putative transporter family; Region: ABG_transport; cl17431 448385003941 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 448385003942 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385003943 von Willebrand factor type A domain; Region: VWA_2; pfam13519 448385003944 metal ion-dependent adhesion site (MIDAS); other site 448385003945 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385003946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385003947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385003948 Walker A motif; other site 448385003949 Walker A/P-loop; other site 448385003950 ATP binding site [chemical binding]; other site 448385003951 ATP binding site [chemical binding]; other site 448385003952 Walker B motif; other site 448385003953 arginine finger; other site 448385003954 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 448385003955 Integral membrane protein DUF95; Region: DUF95; pfam01944 448385003956 RDD family; Region: RDD; pfam06271 448385003957 RDD family; Region: RDD; pfam06271 448385003958 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 448385003959 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385003960 dimerization interface [polypeptide binding]; other site 448385003961 Hpt domain; Region: Hpt; pfam01627 448385003962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385003963 ATP binding site [chemical binding]; other site 448385003964 Mg2+ binding site [ion binding]; other site 448385003965 G-X-G motif; other site 448385003966 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385003967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385003968 active site 448385003969 phosphorylation site [posttranslational modification] 448385003970 intermolecular recognition site; other site 448385003971 dimerization interface [polypeptide binding]; other site 448385003972 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 448385003973 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385003974 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385003975 PAS fold; Region: PAS_4; pfam08448 448385003976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385003977 putative active site [active] 448385003978 heme pocket [chemical binding]; other site 448385003979 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385003980 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385003981 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 448385003982 ligand binding site [chemical binding]; other site 448385003983 PAS domain S-box; Region: sensory_box; TIGR00229 448385003984 PAS fold; Region: PAS_4; pfam08448 448385003985 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385003986 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385003987 dimerization interface [polypeptide binding]; other site 448385003988 putative DNA binding site [nucleotide binding]; other site 448385003989 putative Zn2+ binding site [ion binding]; other site 448385003990 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385003991 putative hydrophobic ligand binding site [chemical binding]; other site 448385003992 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385003993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385003994 active site 448385003995 ATP binding site [chemical binding]; other site 448385003996 substrate binding site [chemical binding]; other site 448385003997 activation loop (A-loop); other site 448385003998 Cupin; Region: Cupin_6; pfam12852 448385003999 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385004000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385004001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385004002 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 448385004003 short chain dehydrogenase; Provisional; Region: PRK06179 448385004004 NADP binding site [chemical binding]; other site 448385004005 active site 448385004006 steroid binding site; other site 448385004007 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 448385004008 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 448385004009 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385004010 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 448385004011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385004012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004013 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004014 active site 448385004015 phosphorylation site [posttranslational modification] 448385004016 intermolecular recognition site; other site 448385004017 dimerization interface [polypeptide binding]; other site 448385004018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385004019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004020 ATP binding site [chemical binding]; other site 448385004021 G-X-G motif; other site 448385004022 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385004023 active site 448385004024 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385004025 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 448385004026 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385004027 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385004028 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 448385004029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385004030 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 448385004031 dimerization interface [polypeptide binding]; other site 448385004032 substrate binding pocket [chemical binding]; other site 448385004033 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385004034 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385004035 ligand binding site [chemical binding]; other site 448385004036 dimerization interface [polypeptide binding]; other site 448385004037 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385004038 TPR repeat; Region: TPR_11; pfam13414 448385004039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004040 binding surface 448385004041 TPR motif; other site 448385004042 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385004043 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385004044 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385004045 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385004046 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385004047 AAA domain; Region: AAA_23; pfam13476 448385004048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385004049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385004050 AAA domain; Region: AAA_21; pfam13304 448385004051 Walker A/P-loop; other site 448385004052 Walker A/P-loop; other site 448385004053 ATP binding site [chemical binding]; other site 448385004054 ATP binding site [chemical binding]; other site 448385004055 TIGR02646 family protein; Region: TIGR02646 448385004056 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004057 active site 448385004058 ATP binding site [chemical binding]; other site 448385004059 substrate binding site [chemical binding]; other site 448385004060 activation loop (A-loop); other site 448385004061 AAA ATPase domain; Region: AAA_16; pfam13191 448385004062 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 448385004063 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385004064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385004065 Walker A motif; other site 448385004066 ATP binding site [chemical binding]; other site 448385004067 Walker B motif; other site 448385004068 arginine finger; other site 448385004069 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385004070 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385004071 dimerization interface [polypeptide binding]; other site 448385004072 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385004073 ligand binding site [chemical binding]; other site 448385004074 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385004075 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 448385004076 Peptidase family M28; Region: Peptidase_M28; pfam04389 448385004077 metal binding site [ion binding]; metal-binding site 448385004078 Cytochrome c552; Region: Cytochrom_C552; pfam02335 448385004079 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 448385004080 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 448385004081 benzoate transport; Region: 2A0115; TIGR00895 448385004082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385004083 putative substrate translocation pore; other site 448385004084 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 448385004085 substrate binding pocket [chemical binding]; other site 448385004086 substrate-Mg2+ binding site; other site 448385004087 aspartate-rich region 1; other site 448385004088 aspartate-rich region 2; other site 448385004089 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 448385004090 substrate binding pocket [chemical binding]; other site 448385004091 substrate-Mg2+ binding site; other site 448385004092 aspartate-rich region 1; other site 448385004093 aspartate-rich region 2; other site 448385004094 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385004095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385004096 ligand binding site [chemical binding]; other site 448385004097 flexible hinge region; other site 448385004098 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385004099 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385004100 ligand binding site [chemical binding]; other site 448385004101 flexible hinge region; other site 448385004102 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385004103 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385004104 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 448385004105 Peptidase family M1; Region: Peptidase_M1; pfam01433 448385004106 Zn binding site [ion binding]; other site 448385004107 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385004108 TAP-like protein; Region: Abhydrolase_4; pfam08386 448385004109 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 448385004110 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 448385004111 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 448385004112 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 448385004113 active site 448385004114 catalytic residues [active] 448385004115 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 448385004116 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 448385004117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385004118 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385004119 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 448385004120 Walker A/P-loop; other site 448385004121 ATP binding site [chemical binding]; other site 448385004122 Q-loop/lid; other site 448385004123 ABC transporter signature motif; other site 448385004124 Walker B; other site 448385004125 D-loop; other site 448385004126 H-loop/switch region; other site 448385004127 transaldolase-like protein; Provisional; Region: PTZ00411 448385004128 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 448385004129 active site 448385004130 dimer interface [polypeptide binding]; other site 448385004131 catalytic residue [active] 448385004132 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385004133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004134 S-adenosylmethionine binding site [chemical binding]; other site 448385004135 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 448385004136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004137 S-adenosylmethionine binding site [chemical binding]; other site 448385004138 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u9; cd10933 448385004139 putative active site [active] 448385004140 putative catalytic site [active] 448385004141 acyl carrier protein; Provisional; Region: acpP; PRK00982 448385004142 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 448385004143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004144 S-adenosylmethionine binding site [chemical binding]; other site 448385004145 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 448385004146 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 448385004147 acyl-activating enzyme (AAE) consensus motif; other site 448385004148 active site 448385004149 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385004150 UL14 tegument protein; Provisional; Region: PHA03187 448385004151 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 448385004152 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385004153 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385004154 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385004155 phosphopeptide binding site; other site 448385004156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385004157 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385004158 Walker A motif; other site 448385004159 ATP binding site [chemical binding]; other site 448385004160 Walker B motif; other site 448385004161 arginine finger; other site 448385004162 Smr domain; Region: Smr; pfam01713 448385004163 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385004164 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385004165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385004166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004167 ATP binding site [chemical binding]; other site 448385004168 Mg2+ binding site [ion binding]; other site 448385004169 G-X-G motif; other site 448385004170 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 448385004171 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385004172 P-loop; other site 448385004173 Magnesium ion binding site [ion binding]; other site 448385004174 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385004175 Magnesium ion binding site [ion binding]; other site 448385004176 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385004177 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385004178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385004179 putative substrate translocation pore; other site 448385004180 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385004181 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 448385004182 substrate binding site [chemical binding]; other site 448385004183 active site 448385004184 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385004185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385004186 DNA binding residues [nucleotide binding] 448385004187 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 448385004188 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 448385004189 active site 448385004190 catalytic triad [active] 448385004191 YCII-related domain; Region: YCII; cl00999 448385004192 YCII-related domain; Region: YCII; cl00999 448385004193 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 448385004194 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 448385004195 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 448385004196 G1 box; other site 448385004197 GTP/Mg2+ binding site [chemical binding]; other site 448385004198 G2 box; other site 448385004199 Switch I region; other site 448385004200 G3 box; other site 448385004201 Switch II region; other site 448385004202 G4 box; other site 448385004203 G5 box; other site 448385004204 Protein kinase domain; Region: Pkinase; pfam00069 448385004205 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385004206 substrate binding site [chemical binding]; other site 448385004207 activation loop (A-loop); other site 448385004208 Predicted ATPase [General function prediction only]; Region: COG3899 448385004209 AAA ATPase domain; Region: AAA_16; pfam13191 448385004210 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385004211 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385004212 PAS fold; Region: PAS_4; pfam08448 448385004213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385004214 putative active site [active] 448385004215 heme pocket [chemical binding]; other site 448385004216 PAS domain S-box; Region: sensory_box; TIGR00229 448385004217 PAS domain; Region: PAS_8; pfam13188 448385004218 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385004219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385004220 dimer interface [polypeptide binding]; other site 448385004221 phosphorylation site [posttranslational modification] 448385004222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004223 ATP binding site [chemical binding]; other site 448385004224 Mg2+ binding site [ion binding]; other site 448385004225 G-X-G motif; other site 448385004226 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385004227 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385004228 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 448385004229 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385004230 Amidase; Region: Amidase; cl11426 448385004231 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 448385004232 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385004233 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385004234 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385004235 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385004236 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385004237 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385004238 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385004239 cyclase homology domain; Region: CHD; cd07302 448385004240 nucleotidyl binding site; other site 448385004241 metal binding site [ion binding]; metal-binding site 448385004242 dimer interface [polypeptide binding]; other site 448385004243 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 448385004244 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 448385004245 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385004246 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385004247 ligand binding site [chemical binding]; other site 448385004248 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004249 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004250 active site 448385004251 ATP binding site [chemical binding]; other site 448385004252 substrate binding site [chemical binding]; other site 448385004253 activation loop (A-loop); other site 448385004254 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385004255 putative C-terminal domain interface [polypeptide binding]; other site 448385004256 putative GSH binding site (G-site) [chemical binding]; other site 448385004257 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385004258 putative dimer interface [polypeptide binding]; other site 448385004259 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 448385004260 dimer interface [polypeptide binding]; other site 448385004261 N-terminal domain interface [polypeptide binding]; other site 448385004262 putative substrate binding pocket (H-site) [chemical binding]; other site 448385004263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004264 S-adenosylmethionine binding site [chemical binding]; other site 448385004265 Transposase domain (DUF772); Region: DUF772; pfam05598 448385004266 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 448385004267 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385004268 Predicted flavoprotein [General function prediction only]; Region: COG0431 448385004269 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385004270 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385004271 active site 448385004272 Cellulose binding domain; Region: CBM_3; cl03026 448385004273 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385004274 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385004275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385004276 DNA binding residues [nucleotide binding] 448385004277 acid-resistance membrane protein; Provisional; Region: PRK10209 448385004278 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 448385004279 SCP-2 sterol transfer family; Region: SCP2; pfam02036 448385004280 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 448385004281 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 448385004282 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385004283 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385004284 active site 448385004285 catalytic tetrad [active] 448385004286 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 448385004287 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 448385004288 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 448385004289 ligand binding site [chemical binding]; other site 448385004290 NAD binding site [chemical binding]; other site 448385004291 catalytic site [active] 448385004292 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 448385004293 Glucose dehydrogenase; Region: glucose_DH; cd08230 448385004294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385004295 NADP binding site [chemical binding]; other site 448385004296 catalytic Zn binding site [ion binding]; other site 448385004297 structural Zn binding site [ion binding]; other site 448385004298 dimer interface [polypeptide binding]; other site 448385004299 Cupin domain; Region: Cupin_2; pfam07883 448385004300 Receptor L domain; Region: Recep_L_domain; pfam01030 448385004301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385004302 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385004303 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 448385004304 putative NAD(P) binding site [chemical binding]; other site 448385004305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385004306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385004307 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 448385004308 YCII-related domain; Region: YCII; cl00999 448385004309 chaperone protein DnaJ; Provisional; Region: PRK14294 448385004310 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385004311 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385004312 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385004313 Biofilm formation and stress response factor; Region: BsmA; pfam10014 448385004314 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 448385004315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385004316 active site 448385004317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385004318 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385004319 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 448385004320 Ligand binding site; other site 448385004321 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 448385004322 intersubunit interface [polypeptide binding]; other site 448385004323 active site 448385004324 Zn2+ binding site [ion binding]; other site 448385004325 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 448385004326 Cupin domain; Region: Cupin_2; pfam07883 448385004327 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 448385004328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385004329 motif II; other site 448385004330 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385004331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004332 active site 448385004333 ATP binding site [chemical binding]; other site 448385004334 substrate binding site [chemical binding]; other site 448385004335 activation loop (A-loop); other site 448385004336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004337 S-adenosylmethionine binding site [chemical binding]; other site 448385004338 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 448385004339 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385004340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385004341 NAD(P) binding site [chemical binding]; other site 448385004342 active site 448385004343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385004344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385004345 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385004346 dimerization interface [polypeptide binding]; other site 448385004347 putative effector binding pocket; other site 448385004348 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385004349 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385004350 putative sugar binding sites [chemical binding]; other site 448385004351 Q-X-W motif; other site 448385004352 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 448385004353 Lamin Tail Domain; Region: LTD; pfam00932 448385004354 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385004355 Sel1-like repeats; Region: SEL1; smart00671 448385004356 Sel1-like repeats; Region: SEL1; smart00671 448385004357 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 448385004358 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385004359 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385004360 serpin-like protein; Provisional; Region: PHA02660 448385004361 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385004362 reactive center loop; other site 448385004363 SIR2-like domain; Region: SIR2_2; pfam13289 448385004364 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 448385004365 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 448385004366 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 448385004367 E3 interaction surface; other site 448385004368 lipoyl attachment site [posttranslational modification]; other site 448385004369 e3 binding domain; Region: E3_binding; pfam02817 448385004370 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 448385004371 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 448385004372 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 448385004373 alpha subunit interface [polypeptide binding]; other site 448385004374 TPP binding site [chemical binding]; other site 448385004375 heterodimer interface [polypeptide binding]; other site 448385004376 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 448385004377 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 448385004378 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 448385004379 TPP-binding site [chemical binding]; other site 448385004380 tetramer interface [polypeptide binding]; other site 448385004381 heterodimer interface [polypeptide binding]; other site 448385004382 phosphorylation loop region [posttranslational modification] 448385004383 tellurite resistance protein terB; Region: terB; cd07176 448385004384 putative metal binding site [ion binding]; other site 448385004385 lipoyl synthase; Provisional; Region: PRK05481 448385004386 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 448385004387 short chain dehydrogenase; Provisional; Region: PRK08278 448385004388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385004389 NAD(P) binding site [chemical binding]; other site 448385004390 active site 448385004391 Galactose binding lectin domain; Region: Gal_Lectin; pfam02140 448385004392 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 448385004393 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 448385004394 Putative esterase; Region: Esterase; pfam00756 448385004395 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 448385004396 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385004397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385004398 FeS/SAM binding site; other site 448385004399 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 448385004400 Ca2+ binding site [ion binding]; other site 448385004401 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385004402 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 448385004403 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 448385004404 FAD binding pocket [chemical binding]; other site 448385004405 conserved FAD binding motif [chemical binding]; other site 448385004406 phosphate binding motif [ion binding]; other site 448385004407 beta-alpha-beta structure motif; other site 448385004408 NAD binding pocket [chemical binding]; other site 448385004409 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 448385004410 active site 448385004411 dimer interface [polypeptide binding]; other site 448385004412 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004413 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004414 active site 448385004415 ATP binding site [chemical binding]; other site 448385004416 substrate binding site [chemical binding]; other site 448385004417 activation loop (A-loop); other site 448385004418 AAA ATPase domain; Region: AAA_16; pfam13191 448385004419 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385004420 Cytochrome P450; Region: p450; cl12078 448385004421 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385004422 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385004423 CHAT domain; Region: CHAT; pfam12770 448385004424 EamA-like transporter family; Region: EamA; pfam00892 448385004425 VWFA-related Acidobacterial domain; Region: acidobact_VWFA; TIGR03436 448385004426 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385004427 metal ion-dependent adhesion site (MIDAS); other site 448385004428 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004430 active site 448385004431 phosphorylation site [posttranslational modification] 448385004432 intermolecular recognition site; other site 448385004433 dimerization interface [polypeptide binding]; other site 448385004434 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 448385004435 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385004436 putative binding surface; other site 448385004437 active site 448385004438 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 448385004439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004440 ATP binding site [chemical binding]; other site 448385004441 Mg2+ binding site [ion binding]; other site 448385004442 G-X-G motif; other site 448385004443 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 448385004444 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 448385004445 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 448385004446 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 448385004447 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 448385004448 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385004449 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 448385004450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004451 active site 448385004452 phosphorylation site [posttranslational modification] 448385004453 intermolecular recognition site; other site 448385004454 dimerization interface [polypeptide binding]; other site 448385004455 CheB methylesterase; Region: CheB_methylest; pfam01339 448385004456 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 448385004457 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385004458 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385004459 catalytic residue [active] 448385004460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385004461 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385004462 Cupin domain; Region: Cupin_2; pfam07883 448385004463 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004464 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004465 active site 448385004466 ATP binding site [chemical binding]; other site 448385004467 substrate binding site [chemical binding]; other site 448385004468 activation loop (A-loop); other site 448385004469 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004470 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004471 active site 448385004472 ATP binding site [chemical binding]; other site 448385004473 substrate binding site [chemical binding]; other site 448385004474 activation loop (A-loop); other site 448385004475 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004476 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004477 active site 448385004478 ATP binding site [chemical binding]; other site 448385004479 substrate binding site [chemical binding]; other site 448385004480 activation loop (A-loop); other site 448385004481 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 448385004482 PEGA domain; Region: PEGA; pfam08308 448385004483 PEGA domain; Region: PEGA; pfam08308 448385004484 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004485 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004486 active site 448385004487 ATP binding site [chemical binding]; other site 448385004488 substrate binding site [chemical binding]; other site 448385004489 activation loop (A-loop); other site 448385004490 PEGA domain; Region: PEGA; pfam08308 448385004491 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 448385004492 G1 box; other site 448385004493 GTP/Mg2+ binding site [chemical binding]; other site 448385004494 G2 box; other site 448385004495 Switch I region; other site 448385004496 G3 box; other site 448385004497 Switch II region; other site 448385004498 UGMP family protein; Validated; Region: PRK09604 448385004499 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 448385004500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004501 binding surface 448385004502 TPR motif; other site 448385004503 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385004504 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385004505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004506 TPR motif; other site 448385004507 binding surface 448385004508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004509 binding surface 448385004510 TPR motif; other site 448385004511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004512 binding surface 448385004513 TPR motif; other site 448385004514 TPR repeat; Region: TPR_11; pfam13414 448385004515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004517 active site 448385004518 ATP binding site [chemical binding]; other site 448385004519 substrate binding site [chemical binding]; other site 448385004520 activation loop (A-loop); other site 448385004521 AAA ATPase domain; Region: AAA_16; pfam13191 448385004522 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385004523 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385004524 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385004525 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385004526 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 448385004527 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 448385004528 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 448385004529 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 448385004530 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 448385004531 tRNA; other site 448385004532 putative tRNA binding site [nucleotide binding]; other site 448385004533 putative NADP binding site [chemical binding]; other site 448385004534 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 448385004535 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 448385004536 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 448385004537 active site 448385004538 domain interfaces; other site 448385004539 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 448385004540 active site 448385004541 substrate binding site [chemical binding]; other site 448385004542 catalytic site [active] 448385004543 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 448385004544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385004545 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385004546 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385004547 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385004548 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 448385004549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 448385004550 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 448385004551 RF-1 domain; Region: RF-1; pfam00472 448385004552 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 448385004553 dimer interface [polypeptide binding]; other site 448385004554 putative anticodon binding site; other site 448385004555 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 448385004556 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 448385004557 motif 1; other site 448385004558 dimer interface [polypeptide binding]; other site 448385004559 active site 448385004560 motif 2; other site 448385004561 motif 3; other site 448385004562 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 448385004563 FtsX-like permease family; Region: FtsX; pfam02687 448385004564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385004565 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385004566 Walker A/P-loop; other site 448385004567 ATP binding site [chemical binding]; other site 448385004568 Q-loop/lid; other site 448385004569 ABC transporter signature motif; other site 448385004570 Walker B; other site 448385004571 D-loop; other site 448385004572 H-loop/switch region; other site 448385004573 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385004574 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385004575 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 448385004576 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 448385004577 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 448385004578 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 448385004579 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 448385004580 shikimate binding site; other site 448385004581 NAD(P) binding site [chemical binding]; other site 448385004582 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 448385004583 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 448385004584 Catalytic site [active] 448385004585 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 448385004586 FtsH Extracellular; Region: FtsH_ext; pfam06480 448385004587 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 448385004588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385004589 Walker A motif; other site 448385004590 ATP binding site [chemical binding]; other site 448385004591 Walker B motif; other site 448385004592 arginine finger; other site 448385004593 Peptidase family M41; Region: Peptidase_M41; pfam01434 448385004594 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385004595 DNA binding residues [nucleotide binding] 448385004596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 448385004597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385004598 NAD(P) binding site [chemical binding]; other site 448385004599 active site 448385004600 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385004601 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 448385004602 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 448385004603 heme binding site [chemical binding]; other site 448385004604 ferroxidase pore; other site 448385004605 ferroxidase diiron center [ion binding]; other site 448385004606 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385004607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004608 active site 448385004609 phosphorylation site [posttranslational modification] 448385004610 intermolecular recognition site; other site 448385004611 dimerization interface [polypeptide binding]; other site 448385004612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385004613 Walker A motif; other site 448385004614 ATP binding site [chemical binding]; other site 448385004615 Walker B motif; other site 448385004616 arginine finger; other site 448385004617 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004619 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004620 active site 448385004621 phosphorylation site [posttranslational modification] 448385004622 intermolecular recognition site; other site 448385004623 dimerization interface [polypeptide binding]; other site 448385004624 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 448385004625 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 448385004626 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 448385004627 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 448385004628 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385004629 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004631 active site 448385004632 phosphorylation site [posttranslational modification] 448385004633 intermolecular recognition site; other site 448385004634 dimerization interface [polypeptide binding]; other site 448385004635 TPR repeat; Region: TPR_11; pfam13414 448385004636 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004637 binding surface 448385004638 TPR motif; other site 448385004639 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 448385004640 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385004641 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 448385004642 B12 binding site [chemical binding]; other site 448385004643 cobalt ligand [ion binding]; other site 448385004644 cell division protein MraZ; Reviewed; Region: PRK00326 448385004645 MraZ protein; Region: MraZ; pfam02381 448385004646 MraZ protein; Region: MraZ; pfam02381 448385004647 MraW methylase family; Region: Methyltransf_5; cl17771 448385004648 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 448385004649 Cell division protein FtsL; Region: FtsL; cl11433 448385004650 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 448385004651 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 448385004652 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 448385004653 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 448385004654 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 448385004655 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 448385004656 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 448385004657 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 448385004658 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 448385004659 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 448385004660 Mg++ binding site [ion binding]; other site 448385004661 putative catalytic motif [active] 448385004662 putative substrate binding site [chemical binding]; other site 448385004663 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 448385004664 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 448385004665 cell division protein FtsW; Region: ftsW; TIGR02614 448385004666 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 448385004667 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 448385004668 active site 448385004669 homodimer interface [polypeptide binding]; other site 448385004670 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 448385004671 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 448385004672 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 448385004673 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 448385004674 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 448385004675 cell division protein FtsA; Region: ftsA; TIGR01174 448385004676 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 448385004677 nucleotide binding site [chemical binding]; other site 448385004678 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 448385004679 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 448385004680 Cell division protein FtsA; Region: FtsA; pfam14450 448385004681 cell division protein FtsZ; Validated; Region: PRK09330 448385004682 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 448385004683 nucleotide binding site [chemical binding]; other site 448385004684 SulA interaction site; other site 448385004685 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 448385004686 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385004687 HSP70 interaction site [polypeptide binding]; other site 448385004688 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 448385004689 Zn binding sites [ion binding]; other site 448385004690 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 448385004691 dimer interface [polypeptide binding]; other site 448385004692 Protease prsW family; Region: PrsW-protease; pfam13367 448385004693 Domain of unknown function (DUF329); Region: DUF329; pfam03884 448385004694 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 448385004695 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385004696 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385004697 protein binding site [polypeptide binding]; other site 448385004698 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385004699 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 448385004700 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385004701 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 448385004702 ligand binding site [chemical binding]; other site 448385004703 flexible hinge region; other site 448385004704 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 448385004705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004706 binding surface 448385004707 TPR motif; other site 448385004708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004709 TPR motif; other site 448385004710 binding surface 448385004711 Helix-turn-helix domain; Region: HTH_25; pfam13413 448385004712 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 448385004713 Recombination protein O N terminal; Region: RecO_N; pfam11967 448385004714 Recombination protein O C terminal; Region: RecO_C; pfam02565 448385004715 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 448385004716 putative active site [active] 448385004717 putative metal binding site [ion binding]; other site 448385004718 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385004719 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 448385004720 Ferrochelatase; Region: Ferrochelatase; pfam00762 448385004721 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 448385004722 active site 448385004723 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 448385004724 active site 448385004725 N-terminal domain interface [polypeptide binding]; other site 448385004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385004727 short chain dehydrogenase; Provisional; Region: PRK06181 448385004728 NAD(P) binding site [chemical binding]; other site 448385004729 active site 448385004730 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385004731 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385004732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385004733 AAA domain; Region: AAA_23; pfam13476 448385004734 Walker A/P-loop; other site 448385004735 ATP binding site [chemical binding]; other site 448385004736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385004737 Walker B; other site 448385004738 D-loop; other site 448385004739 H-loop/switch region; other site 448385004740 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 448385004741 Protein of unknown function DUF262; Region: DUF262; pfam03235 448385004742 Uncharacterized conserved protein [Function unknown]; Region: COG1479 448385004743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004744 active site 448385004745 phosphorylation site [posttranslational modification] 448385004746 intermolecular recognition site; other site 448385004747 dimerization interface [polypeptide binding]; other site 448385004748 Restriction endonuclease; Region: Mrr_cat; pfam04471 448385004749 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385004750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004751 ATP binding site [chemical binding]; other site 448385004752 Mg2+ binding site [ion binding]; other site 448385004753 G-X-G motif; other site 448385004754 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385004755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004756 active site 448385004757 phosphorylation site [posttranslational modification] 448385004758 intermolecular recognition site; other site 448385004759 dimerization interface [polypeptide binding]; other site 448385004760 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385004761 Walker A motif; other site 448385004762 ATP binding site [chemical binding]; other site 448385004763 Walker B motif; other site 448385004764 arginine finger; other site 448385004765 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 448385004766 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 448385004767 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 448385004768 aromatic arch; other site 448385004769 DCoH dimer interaction site [polypeptide binding]; other site 448385004770 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 448385004771 DCoH tetramer interaction site [polypeptide binding]; other site 448385004772 substrate binding site [chemical binding]; other site 448385004773 ribonuclease III; Reviewed; Region: rnc; PRK00102 448385004774 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 448385004775 dimerization interface [polypeptide binding]; other site 448385004776 active site 448385004777 metal binding site [ion binding]; metal-binding site 448385004778 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 448385004779 dsRNA binding site [nucleotide binding]; other site 448385004780 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 448385004781 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 448385004782 exopolyphosphatase; Region: exo_poly_only; TIGR03706 448385004783 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 448385004784 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 448385004785 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385004786 ligand binding site [chemical binding]; other site 448385004787 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385004788 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385004789 active site 448385004790 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 448385004791 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 448385004792 active site 448385004793 catalytic site [active] 448385004794 substrate binding site [chemical binding]; other site 448385004795 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 448385004796 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 448385004797 active site 448385004798 (T/H)XGH motif; other site 448385004799 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 448385004800 Peptidase family M50; Region: Peptidase_M50; pfam02163 448385004801 active site 448385004802 putative substrate binding region [chemical binding]; other site 448385004803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385004804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385004805 active site 448385004806 ATP binding site [chemical binding]; other site 448385004807 substrate binding site [chemical binding]; other site 448385004808 activation loop (A-loop); other site 448385004809 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 448385004810 active site 448385004811 NTP binding site [chemical binding]; other site 448385004812 metal binding triad [ion binding]; metal-binding site 448385004813 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 448385004814 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385004815 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 448385004816 nudix motif; other site 448385004817 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385004818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385004819 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 448385004820 active site 448385004821 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 448385004822 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 448385004823 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385004824 cyclase homology domain; Region: CHD; cd07302 448385004825 nucleotidyl binding site; other site 448385004826 metal binding site [ion binding]; metal-binding site 448385004827 dimer interface [polypeptide binding]; other site 448385004828 oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538 448385004829 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004831 active site 448385004832 phosphorylation site [posttranslational modification] 448385004833 intermolecular recognition site; other site 448385004834 dimerization interface [polypeptide binding]; other site 448385004835 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004837 active site 448385004838 phosphorylation site [posttranslational modification] 448385004839 intermolecular recognition site; other site 448385004840 dimerization interface [polypeptide binding]; other site 448385004841 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 448385004842 putative active site pocket [active] 448385004843 dimerization interface [polypeptide binding]; other site 448385004844 putative catalytic residue [active] 448385004845 CheB methylesterase; Region: CheB_methylest; pfam01339 448385004846 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 448385004847 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 448385004848 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385004849 PAS domain; Region: PAS_10; pfam13596 448385004850 PAS fold; Region: PAS_4; pfam08448 448385004851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385004852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385004853 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 448385004854 Fe-S cluster binding site [ion binding]; other site 448385004855 active site 448385004856 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 448385004857 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 448385004858 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 448385004859 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 448385004860 dimer interface [polypeptide binding]; other site 448385004861 active site 448385004862 oxalacetate/citrate binding site [chemical binding]; other site 448385004863 citrylCoA binding site [chemical binding]; other site 448385004864 coenzyme A binding site [chemical binding]; other site 448385004865 catalytic triad [active] 448385004866 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 448385004867 Citrate synthase; Region: Citrate_synt; pfam00285 448385004868 oxalacetate binding site [chemical binding]; other site 448385004869 citrylCoA binding site [chemical binding]; other site 448385004870 coenzyme A binding site [chemical binding]; other site 448385004871 catalytic triad [active] 448385004872 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385004873 Walker A motif; other site 448385004874 ATP binding site [chemical binding]; other site 448385004875 Walker B motif; other site 448385004876 Y-family of DNA polymerases; Region: PolY; cl12025 448385004877 DNA binding site [nucleotide binding] 448385004878 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 448385004879 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 448385004880 putative active site [active] 448385004881 putative PHP Thumb interface [polypeptide binding]; other site 448385004882 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 448385004883 generic binding surface II; other site 448385004884 generic binding surface I; other site 448385004885 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 448385004886 dimer interface [polypeptide binding]; other site 448385004887 phosphorylation site [posttranslational modification] 448385004888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385004889 ATP binding site [chemical binding]; other site 448385004890 Mg2+ binding site [ion binding]; other site 448385004891 G-X-G motif; other site 448385004892 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004894 active site 448385004895 phosphorylation site [posttranslational modification] 448385004896 intermolecular recognition site; other site 448385004897 dimerization interface [polypeptide binding]; other site 448385004898 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 448385004899 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 448385004900 Walker A/P-loop; other site 448385004901 ATP binding site [chemical binding]; other site 448385004902 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 448385004903 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 448385004904 ABC transporter signature motif; other site 448385004905 Walker B; other site 448385004906 D-loop; other site 448385004907 H-loop/switch region; other site 448385004908 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 448385004909 Chorismate mutase type II; Region: CM_2; cl00693 448385004910 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 448385004911 Prephenate dehydratase; Region: PDT; pfam00800 448385004912 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 448385004913 putative L-Phe binding site [chemical binding]; other site 448385004914 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 448385004915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385004916 ATP binding site [chemical binding]; other site 448385004917 putative Mg++ binding site [ion binding]; other site 448385004918 helicase superfamily c-terminal domain; Region: HELICc; smart00490 448385004919 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 448385004920 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 448385004921 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385004922 Amidase; Region: Amidase; cl11426 448385004923 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385004924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385004925 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 448385004926 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 448385004927 metal binding site 2 [ion binding]; metal-binding site 448385004928 putative DNA binding helix; other site 448385004929 metal binding site 1 [ion binding]; metal-binding site 448385004930 structural Zn2+ binding site [ion binding]; other site 448385004931 Rubrerythrin [Energy production and conversion]; Region: COG1592 448385004932 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 448385004933 binuclear metal center [ion binding]; other site 448385004934 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 448385004935 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 448385004936 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 448385004937 active site 448385004938 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385004939 PLD-like domain; Region: PLDc_2; pfam13091 448385004940 putative active site [active] 448385004941 catalytic site [active] 448385004942 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 448385004943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385004944 active site 448385004945 dimer interface [polypeptide binding]; other site 448385004946 Lyase; Region: Lyase_1; pfam00206 448385004947 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 448385004948 active sites [active] 448385004949 tetramer interface [polypeptide binding]; other site 448385004950 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 448385004951 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 448385004952 homotetramer interface [polypeptide binding]; other site 448385004953 FMN binding site [chemical binding]; other site 448385004954 homodimer contacts [polypeptide binding]; other site 448385004955 putative active site [active] 448385004956 putative substrate binding site [chemical binding]; other site 448385004957 GAF domain; Region: GAF_3; pfam13492 448385004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385004959 Response regulator receiver domain; Region: Response_reg; pfam00072 448385004960 active site 448385004961 phosphorylation site [posttranslational modification] 448385004962 intermolecular recognition site; other site 448385004963 dimerization interface [polypeptide binding]; other site 448385004964 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385004965 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385004966 phosphopeptide binding site; other site 448385004967 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385004968 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385004969 metal binding site [ion binding]; metal-binding site 448385004970 active site 448385004971 I-site; other site 448385004972 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 448385004973 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 448385004974 metal binding triad; other site 448385004975 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 448385004976 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 448385004977 metal binding triad; other site 448385004978 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 448385004979 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385004980 hypothetical protein; Provisional; Region: PRK05325 448385004981 SpoVR like protein; Region: SpoVR; pfam04293 448385004982 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 448385004983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004984 TPR motif; other site 448385004985 TPR repeat; Region: TPR_11; pfam13414 448385004986 binding surface 448385004987 TPR repeat; Region: TPR_11; pfam13414 448385004988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385004989 TPR motif; other site 448385004990 binding surface 448385004991 TPR repeat; Region: TPR_11; pfam13414 448385004992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 448385004993 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385004994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385004995 S-adenosylmethionine binding site [chemical binding]; other site 448385004996 Cache domain; Region: Cache_1; pfam02743 448385004997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385004998 dimerization interface [polypeptide binding]; other site 448385004999 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385005000 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385005001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381 448385005002 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 448385005003 anti sigma factor interaction site; other site 448385005004 regulatory phosphorylation site [posttranslational modification]; other site 448385005005 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385005006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385005007 putative active site [active] 448385005008 heme pocket [chemical binding]; other site 448385005009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385005010 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385005011 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385005012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385005013 MarR family; Region: MarR; pfam01047 448385005014 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 448385005015 enoyl-CoA hydratase; Provisional; Region: PRK05995 448385005016 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385005017 substrate binding site [chemical binding]; other site 448385005018 oxyanion hole (OAH) forming residues; other site 448385005019 trimer interface [polypeptide binding]; other site 448385005020 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 448385005021 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 448385005022 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 448385005023 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 448385005024 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 448385005025 thiamine phosphate binding site [chemical binding]; other site 448385005026 active site 448385005027 pyrophosphate binding site [ion binding]; other site 448385005028 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 448385005029 DNA polymerase III subunit delta'; Validated; Region: PRK08485 448385005030 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 448385005031 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385005032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005033 NAD(P) binding site [chemical binding]; other site 448385005034 active site 448385005035 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 448385005036 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385005037 acyl-activating enzyme (AAE) consensus motif; other site 448385005038 active site 448385005039 AMP binding site [chemical binding]; other site 448385005040 CoA binding site [chemical binding]; other site 448385005041 TIR domain; Region: TIR_2; pfam13676 448385005042 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005043 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385005044 active site 448385005045 ATP binding site [chemical binding]; other site 448385005046 substrate binding site [chemical binding]; other site 448385005047 activation loop (A-loop); other site 448385005048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005049 NAD(P) binding site [chemical binding]; other site 448385005050 active site 448385005051 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385005052 putative active site [active] 448385005053 CotH protein; Region: CotH; pfam08757 448385005054 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 448385005055 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 448385005056 GTP1/OBG; Region: GTP1_OBG; pfam01018 448385005057 Obg GTPase; Region: Obg; cd01898 448385005058 G1 box; other site 448385005059 GTP/Mg2+ binding site [chemical binding]; other site 448385005060 Switch I region; other site 448385005061 G2 box; other site 448385005062 G3 box; other site 448385005063 Switch II region; other site 448385005064 G4 box; other site 448385005065 G5 box; other site 448385005066 Response regulator receiver domain; Region: Response_reg; pfam00072 448385005067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005068 active site 448385005069 phosphorylation site [posttranslational modification] 448385005070 intermolecular recognition site; other site 448385005071 dimerization interface [polypeptide binding]; other site 448385005072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005073 ATP binding site [chemical binding]; other site 448385005074 G-X-G motif; other site 448385005075 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 448385005076 Ca2+ binding site [ion binding]; other site 448385005077 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 448385005078 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 448385005079 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385005080 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 448385005081 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385005082 catalytic site [active] 448385005083 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 448385005084 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 448385005085 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 448385005086 HEAT repeats; Region: HEAT_2; pfam13646 448385005087 HEAT repeats; Region: HEAT_2; pfam13646 448385005088 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 448385005089 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 448385005090 tellurium resistance terB-like protein; Region: terB_like; cl11965 448385005091 metal binding site [ion binding]; metal-binding site 448385005092 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 448385005093 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 448385005094 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 448385005095 NAD binding site [chemical binding]; other site 448385005096 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385005097 ZU5 domain; Region: ZU5; cl02517 448385005098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 448385005099 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385005100 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 448385005101 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385005102 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 448385005103 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 448385005104 Strictosidine synthase; Region: Str_synth; pfam03088 448385005105 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385005106 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 448385005107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385005108 FeS/SAM binding site; other site 448385005109 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 448385005110 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385005111 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385005112 putative active site [active] 448385005113 putative metal binding site [ion binding]; other site 448385005114 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 448385005115 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 448385005116 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 448385005117 DNA methylase; Region: N6_N4_Mtase; pfam01555 448385005118 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385005119 Restriction endonuclease; Region: Mrr_cat; pfam04471 448385005120 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 448385005121 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 448385005122 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 448385005123 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 448385005124 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385005125 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 448385005126 catalytic loop [active] 448385005127 iron binding site [ion binding]; other site 448385005128 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213 448385005129 FAD binding pocket [chemical binding]; other site 448385005130 FAD binding motif [chemical binding]; other site 448385005131 phosphate binding motif [ion binding]; other site 448385005132 beta-alpha-beta structure motif; other site 448385005133 NAD binding pocket [chemical binding]; other site 448385005134 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 448385005135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385005136 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 448385005137 substrate binding pocket [chemical binding]; other site 448385005138 dimerization interface [polypeptide binding]; other site 448385005139 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005140 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005141 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005142 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005143 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005144 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005145 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385005146 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385005147 protein binding site [polypeptide binding]; other site 448385005148 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385005149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385005150 Walker A motif; other site 448385005151 ATP binding site [chemical binding]; other site 448385005152 Walker B motif; other site 448385005153 arginine finger; other site 448385005154 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385005155 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005156 active site 448385005157 ATP binding site [chemical binding]; other site 448385005158 substrate binding site [chemical binding]; other site 448385005159 activation loop (A-loop); other site 448385005160 cyclase homology domain; Region: CHD; cd07302 448385005161 metal binding site [ion binding]; metal-binding site 448385005162 AAA ATPase domain; Region: AAA_16; pfam13191 448385005163 Alphaherpesvirus glycoprotein I; Region: Herpes_gI; cl17328 448385005164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005165 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005167 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005168 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005169 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005170 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005171 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005172 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005173 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005174 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385005175 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385005176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005177 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385005178 active site 448385005179 ATP binding site [chemical binding]; other site 448385005180 substrate binding site [chemical binding]; other site 448385005181 activation loop (A-loop); other site 448385005182 AAA ATPase domain; Region: AAA_16; pfam13191 448385005183 AAA domain; Region: AAA_22; pfam13401 448385005184 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385005185 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385005186 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005187 active site 448385005188 ATP binding site [chemical binding]; other site 448385005189 substrate binding site [chemical binding]; other site 448385005190 activation loop (A-loop); other site 448385005191 Cyclic phosphodiesterase-like protein; Region: CPDase; pfam07823 448385005192 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 448385005193 Nitronate monooxygenase; Region: NMO; pfam03060 448385005194 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 448385005195 FMN binding site [chemical binding]; other site 448385005196 substrate binding site [chemical binding]; other site 448385005197 putative catalytic residue [active] 448385005198 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005199 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385005200 active site 448385005201 ATP binding site [chemical binding]; other site 448385005202 substrate binding site [chemical binding]; other site 448385005203 activation loop (A-loop); other site 448385005204 AAA ATPase domain; Region: AAA_16; pfam13191 448385005205 Predicted ATPase [General function prediction only]; Region: COG3899 448385005206 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385005207 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385005208 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385005209 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385005210 dimer interface [polypeptide binding]; other site 448385005211 phosphorylation site [posttranslational modification] 448385005212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005213 ATP binding site [chemical binding]; other site 448385005214 Mg2+ binding site [ion binding]; other site 448385005215 G-X-G motif; other site 448385005216 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385005217 Cytochrome P450; Region: p450; pfam00067 448385005218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385005219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 448385005220 substrate binding pocket [chemical binding]; other site 448385005221 membrane-bound complex binding site; other site 448385005222 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385005223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 448385005224 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 448385005225 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385005226 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385005227 Walker A/P-loop; other site 448385005228 ATP binding site [chemical binding]; other site 448385005229 Q-loop/lid; other site 448385005230 ABC transporter signature motif; other site 448385005231 Walker B; other site 448385005232 D-loop; other site 448385005233 H-loop/switch region; other site 448385005234 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 448385005235 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 448385005236 homodimer interface [polypeptide binding]; other site 448385005237 active site 448385005238 TDP-binding site; other site 448385005239 acceptor substrate-binding pocket; other site 448385005240 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385005241 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385005242 ligand binding site [chemical binding]; other site 448385005243 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 448385005244 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 448385005245 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 448385005246 Predicted membrane protein [Function unknown]; Region: COG2259 448385005247 Hemerythrin-like domain; Region: Hr-like; cd12108 448385005248 Fe binding site [ion binding]; other site 448385005249 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385005250 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385005251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385005252 active site 448385005253 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385005254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385005255 active site 448385005256 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 448385005257 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 448385005258 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385005259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385005260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385005261 DNA binding residues [nucleotide binding] 448385005262 Predicted flavoprotein [General function prediction only]; Region: COG0431 448385005263 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385005264 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385005265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385005266 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 448385005267 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 448385005268 iron-sulfur cluster [ion binding]; other site 448385005269 [2Fe-2S] cluster binding site [ion binding]; other site 448385005270 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 448385005271 hydrophobic ligand binding site; other site 448385005272 hypothetical protein; Provisional; Region: PRK05409 448385005273 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 448385005274 active site 448385005275 NTP binding site [chemical binding]; other site 448385005276 metal binding triad [ion binding]; metal-binding site 448385005277 antibiotic binding site [chemical binding]; other site 448385005278 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385005279 active site 448385005280 iron coordination sites [ion binding]; other site 448385005281 substrate binding pocket [chemical binding]; other site 448385005282 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385005283 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 448385005284 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385005285 putative transposase OrfB; Reviewed; Region: PHA02517 448385005286 Integrase core domain; Region: rve; pfam00665 448385005287 Putative transposase; Region: Y2_Tnp; pfam04986 448385005288 Winged helix-turn helix; Region: HTH_29; pfam13551 448385005289 Homeodomain-like domain; Region: HTH_32; pfam13565 448385005290 Integrase core domain; Region: rve; pfam00665 448385005291 DDE domain; Region: DDE_Tnp_IS240; pfam13610 448385005292 Integrase core domain; Region: rve_3; pfam13683 448385005293 Transposase; Region: HTH_Tnp_1; cl17663 448385005294 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 448385005295 kynureninase; Region: kynureninase; TIGR01814 448385005296 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385005297 catalytic residue [active] 448385005298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005299 S-adenosylmethionine binding site [chemical binding]; other site 448385005300 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 448385005301 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 448385005302 DNA binding residues [nucleotide binding] 448385005303 putative dimer interface [polypeptide binding]; other site 448385005304 putative metal binding residues [ion binding]; other site 448385005305 H-type lectin domain; Region: H_lectin; pfam09458 448385005306 CHAT domain; Region: CHAT; cl17868 448385005307 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 448385005308 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385005309 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 448385005310 putative active site [active] 448385005311 putative NTP binding site [chemical binding]; other site 448385005312 putative nucleic acid binding site [nucleotide binding]; other site 448385005313 SWIM zinc finger; Region: SWIM; pfam04434 448385005314 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385005315 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385005316 structural tetrad; other site 448385005317 HEAT repeats; Region: HEAT_2; pfam13646 448385005318 HEAT repeats; Region: HEAT_2; pfam13646 448385005319 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 448385005320 HEAT repeats; Region: HEAT_2; pfam13646 448385005321 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 448385005322 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 448385005323 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385005324 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385005325 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 448385005326 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 448385005327 active site 448385005328 substrate binding site [chemical binding]; other site 448385005329 Mg2+ binding site [ion binding]; other site 448385005330 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 448385005331 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 448385005332 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 448385005333 active site 448385005334 intersubunit interface [polypeptide binding]; other site 448385005335 zinc binding site [ion binding]; other site 448385005336 Na+ binding site [ion binding]; other site 448385005337 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385005338 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 448385005339 TrkA-C domain; Region: TrkA_C; pfam02080 448385005340 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 448385005341 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 448385005342 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 448385005343 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385005344 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 448385005345 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 448385005346 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 448385005347 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 448385005348 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385005349 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 448385005350 Response regulator receiver domain; Region: Response_reg; pfam00072 448385005351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005352 active site 448385005353 phosphorylation site [posttranslational modification] 448385005354 intermolecular recognition site; other site 448385005355 dimerization interface [polypeptide binding]; other site 448385005356 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385005357 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385005358 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385005359 dimerization interface [polypeptide binding]; other site 448385005360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385005361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385005362 dimer interface [polypeptide binding]; other site 448385005363 phosphorylation site [posttranslational modification] 448385005364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005365 ATP binding site [chemical binding]; other site 448385005366 Mg2+ binding site [ion binding]; other site 448385005367 G-X-G motif; other site 448385005368 Response regulator receiver domain; Region: Response_reg; pfam00072 448385005369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005370 active site 448385005371 phosphorylation site [posttranslational modification] 448385005372 intermolecular recognition site; other site 448385005373 dimerization interface [polypeptide binding]; other site 448385005374 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 448385005375 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 448385005376 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385005377 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385005378 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385005379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385005380 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385005381 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385005382 phosphopeptide binding site; other site 448385005383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385005384 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385005385 Walker A motif; other site 448385005386 ATP binding site [chemical binding]; other site 448385005387 Walker B motif; other site 448385005388 arginine finger; other site 448385005389 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385005391 active site 448385005392 ATP binding site [chemical binding]; other site 448385005393 substrate binding site [chemical binding]; other site 448385005394 activation loop (A-loop); other site 448385005395 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 448385005396 BNR repeat-like domain; Region: BNR_2; pfam13088 448385005397 hypothetical protein; Reviewed; Region: PRK09588 448385005398 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 448385005399 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 448385005400 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 448385005401 substrate binding site [chemical binding]; other site 448385005402 active site 448385005403 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 448385005404 metal binding site [ion binding]; metal-binding site 448385005405 ligand binding site [chemical binding]; other site 448385005406 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 448385005407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005408 S-adenosylmethionine binding site [chemical binding]; other site 448385005409 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 448385005410 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 448385005411 Ligand binding site; other site 448385005412 Putative Catalytic site; other site 448385005413 DXD motif; other site 448385005414 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 448385005415 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 448385005416 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 448385005417 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385005418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385005419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385005420 Peptidase C13 family; Region: Peptidase_C13; cl02159 448385005421 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 448385005422 DinB superfamily; Region: DinB_2; pfam12867 448385005423 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385005424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005425 S-adenosylmethionine binding site [chemical binding]; other site 448385005426 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385005427 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385005428 active site 448385005429 catalytic tetrad [active] 448385005430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 448385005431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005432 S-adenosylmethionine binding site [chemical binding]; other site 448385005433 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 448385005434 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 448385005435 amphipathic channel; other site 448385005436 Asn-Pro-Ala signature motifs; other site 448385005437 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 448385005438 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 448385005439 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385005440 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 448385005441 Catalytic dyad [active] 448385005442 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385005443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005446 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385005447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005448 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385005449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005450 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005451 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385005452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005454 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005455 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385005456 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385005457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005459 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005460 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005461 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385005462 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385005463 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 448385005464 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 448385005465 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 448385005466 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 448385005467 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 448385005468 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 448385005469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005470 S-adenosylmethionine binding site [chemical binding]; other site 448385005471 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385005472 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385005473 active site 448385005474 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 448385005475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385005476 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385005477 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 448385005478 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385005479 Creatinine amidohydrolase; Region: Creatininase; pfam02633 448385005480 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385005481 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 448385005482 acyl-activating enzyme (AAE) consensus motif; other site 448385005483 AMP binding site [chemical binding]; other site 448385005484 active site 448385005485 CoA binding site [chemical binding]; other site 448385005486 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 448385005487 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 448385005488 active site 448385005489 FMN binding site [chemical binding]; other site 448385005490 substrate binding site [chemical binding]; other site 448385005491 putative catalytic residue [active] 448385005492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385005493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385005494 active site 448385005495 enoyl-CoA hydratase; Provisional; Region: PRK06688 448385005496 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385005497 substrate binding site [chemical binding]; other site 448385005498 oxyanion hole (OAH) forming residues; other site 448385005499 trimer interface [polypeptide binding]; other site 448385005500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385005501 MarR family; Region: MarR; pfam01047 448385005502 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 448385005503 homotrimer interaction site [polypeptide binding]; other site 448385005504 putative active site [active] 448385005505 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385005506 classical (c) SDRs; Region: SDR_c; cd05233 448385005507 NAD(P) binding site [chemical binding]; other site 448385005508 active site 448385005509 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385005510 putative active site [active] 448385005511 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 448385005512 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385005513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385005514 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 448385005515 TPR repeat; Region: TPR_11; pfam13414 448385005516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385005517 binding surface 448385005518 TPR motif; other site 448385005519 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385005520 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 448385005521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385005522 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385005523 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385005524 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385005525 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385005526 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385005527 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385005528 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 448385005529 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 448385005530 tetramer interface [polypeptide binding]; other site 448385005531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385005532 catalytic residue [active] 448385005533 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 448385005534 lipoyl attachment site [posttranslational modification]; other site 448385005535 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 448385005536 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 448385005537 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 448385005538 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 448385005539 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 448385005540 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 448385005541 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385005542 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 448385005543 dimer interaction site [polypeptide binding]; other site 448385005544 substrate-binding tunnel; other site 448385005545 active site 448385005546 catalytic site [active] 448385005547 substrate binding site [chemical binding]; other site 448385005548 Double zinc ribbon; Region: DZR; pfam12773 448385005549 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005550 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385005551 active site 448385005552 ATP binding site [chemical binding]; other site 448385005553 substrate binding site [chemical binding]; other site 448385005554 activation loop (A-loop); other site 448385005555 ScpA/B protein; Region: ScpA_ScpB; cl00598 448385005556 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 448385005557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385005558 non-specific DNA binding site [nucleotide binding]; other site 448385005559 salt bridge; other site 448385005560 sequence-specific DNA binding site [nucleotide binding]; other site 448385005561 Lamin Tail Domain; Region: LTD; pfam00932 448385005562 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 448385005563 DNA binding residues [nucleotide binding] 448385005564 peptidase PmbA; Provisional; Region: PRK11040 448385005565 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 448385005566 AIR carboxylase; Region: AIRC; smart01001 448385005567 hypothetical protein; Provisional; Region: PRK04194 448385005568 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385005569 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385005570 catalytic residues [active] 448385005571 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 448385005572 active site residue [active] 448385005573 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 448385005574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385005575 dimer interface [polypeptide binding]; other site 448385005576 putative PBP binding loops; other site 448385005577 ABC-ATPase subunit interface; other site 448385005578 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 448385005579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 448385005580 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385005581 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385005582 phosphopeptide binding site; other site 448385005583 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385005584 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 448385005585 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385005586 active site 448385005587 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 448385005588 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385005589 Protein phosphatase 2C; Region: PP2C; pfam00481 448385005590 active site 448385005591 Double zinc ribbon; Region: DZR; pfam12773 448385005592 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385005593 phosphopeptide binding site; other site 448385005594 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385005595 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385005596 phosphopeptide binding site; other site 448385005597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385005598 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 448385005599 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385005600 catalytic residue [active] 448385005601 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 448385005602 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385005603 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385005604 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 448385005605 dimer interface [polypeptide binding]; other site 448385005606 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385005607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005608 active site 448385005609 phosphorylation site [posttranslational modification] 448385005610 intermolecular recognition site; other site 448385005611 dimerization interface [polypeptide binding]; other site 448385005612 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385005613 DNA binding site [nucleotide binding] 448385005614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385005615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385005616 dimerization interface [polypeptide binding]; other site 448385005617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385005618 dimer interface [polypeptide binding]; other site 448385005619 phosphorylation site [posttranslational modification] 448385005620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005621 ATP binding site [chemical binding]; other site 448385005622 G-X-G motif; other site 448385005623 Response regulator receiver domain; Region: Response_reg; pfam00072 448385005624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005625 active site 448385005626 phosphorylation site [posttranslational modification] 448385005627 intermolecular recognition site; other site 448385005628 dimerization interface [polypeptide binding]; other site 448385005629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385005630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385005631 TPR motif; other site 448385005632 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385005633 epithiospecifier protein; Region: PLN02153 448385005634 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385005635 active site 448385005636 ATP binding site [chemical binding]; other site 448385005637 substrate binding site [chemical binding]; other site 448385005638 activation loop (A-loop); other site 448385005639 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 448385005640 muropeptide transporter; Validated; Region: ampG; cl17669 448385005641 muropeptide transporter; Validated; Region: ampG; cl17669 448385005642 CAAX protease self-immunity; Region: Abi; pfam02517 448385005643 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385005644 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385005645 PLD-like domain; Region: PLDc_2; pfam13091 448385005646 putative active site [active] 448385005647 catalytic site [active] 448385005648 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 448385005649 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 448385005650 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 448385005651 active site 448385005652 dimer interface [polypeptide binding]; other site 448385005653 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 448385005654 Ligand Binding Site [chemical binding]; other site 448385005655 Molecular Tunnel; other site 448385005656 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385005657 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385005658 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385005659 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385005660 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385005661 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385005662 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385005663 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385005664 ligand binding site [chemical binding]; other site 448385005665 flexible hinge region; other site 448385005666 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 448385005667 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 448385005668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385005669 active site 448385005670 Integrase core domain; Region: rve; pfam00665 448385005671 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 448385005672 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 448385005673 active site 448385005674 NTP binding site [chemical binding]; other site 448385005675 metal binding triad [ion binding]; metal-binding site 448385005676 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 448385005677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385005678 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 448385005679 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 448385005680 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 448385005681 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 448385005682 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385005683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385005684 Walker A motif; other site 448385005685 ATP binding site [chemical binding]; other site 448385005686 Walker B motif; other site 448385005687 arginine finger; other site 448385005688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385005689 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385005690 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385005691 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 448385005692 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 448385005693 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 448385005694 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 448385005695 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 448385005696 Popeye protein conserved region; Region: Popeye; pfam04831 448385005697 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 448385005698 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 448385005699 US22 like; Region: US22; pfam02393 448385005700 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 448385005701 HEAT repeats; Region: HEAT_2; pfam13646 448385005702 Transposase; Region: DDE_Tnp_ISL3; pfam01610 448385005703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 448385005704 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 448385005706 hydroperoxidase II; Provisional; Region: katE; PRK11249 448385005707 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 448385005708 heme binding pocket [chemical binding]; other site 448385005709 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385005710 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 448385005711 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 448385005712 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 448385005713 putative active site [active] 448385005714 redox center [active] 448385005715 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385005716 FAD binding domain; Region: FAD_binding_4; pfam01565 448385005717 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 448385005718 Cysteine-rich domain; Region: CCG; pfam02754 448385005719 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 448385005720 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 448385005721 metal binding site [ion binding]; metal-binding site 448385005722 substrate binding pocket [chemical binding]; other site 448385005723 thiamine pyrophosphate protein; Provisional; Region: PRK08273 448385005724 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 448385005725 PYR/PP interface [polypeptide binding]; other site 448385005726 dimer interface [polypeptide binding]; other site 448385005727 tetramer interface [polypeptide binding]; other site 448385005728 TPP binding site [chemical binding]; other site 448385005729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 448385005730 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 448385005731 TPP-binding site [chemical binding]; other site 448385005732 short chain dehydrogenase; Provisional; Region: PRK07109 448385005733 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 448385005734 putative NAD(P) binding site [chemical binding]; other site 448385005735 active site 448385005736 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385005737 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385005738 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385005739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385005740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385005741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385005742 dimerization interface [polypeptide binding]; other site 448385005743 TIGR02679 family protein; Region: TIGR02679 448385005744 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 448385005745 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 448385005746 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 448385005747 TIGR02677 family protein; Region: TIGR02677 448385005748 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 448385005749 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 448385005750 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385005751 DNA binding residues [nucleotide binding] 448385005752 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 448385005753 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 448385005754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385005755 metal ion-dependent adhesion site (MIDAS); other site 448385005756 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385005757 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 448385005758 ligand binding site [chemical binding]; other site 448385005759 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 448385005760 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 448385005761 malonyl-CoA binding site [chemical binding]; other site 448385005762 dimer interface [polypeptide binding]; other site 448385005763 active site 448385005764 product binding site; other site 448385005765 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385005766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385005767 active site 448385005768 catalytic tetrad [active] 448385005769 SnoaL-like domain; Region: SnoaL_2; pfam12680 448385005770 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 448385005771 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 448385005772 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385005773 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 448385005774 Filamin/ABP280 repeat; Region: Filamin; pfam00630 448385005775 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 448385005776 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 448385005777 Cu(I) binding site [ion binding]; other site 448385005778 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 448385005779 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 448385005780 Cu(I) binding site [ion binding]; other site 448385005781 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 448385005782 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385005783 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385005784 putative active site [active] 448385005785 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385005786 putative active site [active] 448385005787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005789 S-adenosylmethionine binding site [chemical binding]; other site 448385005790 GTPases [General function prediction only]; Region: HflX; COG2262 448385005791 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 448385005792 HflX GTPase family; Region: HflX; cd01878 448385005793 G1 box; other site 448385005794 GTP/Mg2+ binding site [chemical binding]; other site 448385005795 Switch I region; other site 448385005796 G2 box; other site 448385005797 G3 box; other site 448385005798 Switch II region; other site 448385005799 G4 box; other site 448385005800 G5 box; other site 448385005801 phosphoenolpyruvate synthase; Validated; Region: PRK06241 448385005802 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385005803 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385005804 N-terminal domain interface [polypeptide binding]; other site 448385005805 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385005806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385005807 WHG domain; Region: WHG; pfam13305 448385005808 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 448385005809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005810 NAD(P) binding site [chemical binding]; other site 448385005811 active site 448385005812 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385005813 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 448385005814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385005815 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 448385005816 YCII-related domain; Region: YCII; cl00999 448385005817 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385005818 putative sugar binding sites [chemical binding]; other site 448385005819 Q-X-W motif; other site 448385005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 448385005821 phosphorylation site [posttranslational modification] 448385005822 intermolecular recognition site; other site 448385005823 Leucine carboxyl methyltransferase; Region: LCM; cl01306 448385005824 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 448385005825 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 448385005826 NAD(P) binding site [chemical binding]; other site 448385005827 catalytic residues [active] 448385005828 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385005829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385005830 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385005831 haloalkane dehalogenase; Provisional; Region: PRK03592 448385005832 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 448385005833 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385005834 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 448385005835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385005836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385005837 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385005838 substrate binding pocket [chemical binding]; other site 448385005839 dimerization interface [polypeptide binding]; other site 448385005840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005841 NAD(P) binding site [chemical binding]; other site 448385005842 active site 448385005843 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 448385005844 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 448385005845 malonyl-CoA binding site [chemical binding]; other site 448385005846 dimer interface [polypeptide binding]; other site 448385005847 active site 448385005848 product binding site; other site 448385005849 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385005851 S-adenosylmethionine binding site [chemical binding]; other site 448385005852 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 448385005853 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385005854 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385005855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385005856 DNA binding residues [nucleotide binding] 448385005857 FecR protein; Region: FecR; pfam04773 448385005858 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 448385005859 legume lectins; Region: lectin_L-type; cd01951 448385005860 homotetramer interaction site [polypeptide binding]; other site 448385005861 carbohydrate binding site [chemical binding]; other site 448385005862 metal binding site [ion binding]; metal-binding site 448385005863 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 448385005864 Cytochrome P450; Region: p450; cl12078 448385005865 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385005866 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 448385005867 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 448385005868 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 448385005869 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 448385005870 C-terminal domain interface [polypeptide binding]; other site 448385005871 GSH binding site (G-site) [chemical binding]; other site 448385005872 dimer interface [polypeptide binding]; other site 448385005873 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385005874 N-terminal domain interface [polypeptide binding]; other site 448385005875 dimer interface [polypeptide binding]; other site 448385005876 substrate binding pocket (H-site) [chemical binding]; other site 448385005877 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 448385005878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385005879 dimerization interface [polypeptide binding]; other site 448385005880 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 448385005881 dimer interface [polypeptide binding]; other site 448385005882 putative CheW interface [polypeptide binding]; other site 448385005883 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385005884 putative binding surface; other site 448385005885 active site 448385005886 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 448385005887 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 448385005888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005889 ATP binding site [chemical binding]; other site 448385005890 Mg2+ binding site [ion binding]; other site 448385005891 G-X-G motif; other site 448385005892 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 448385005893 CheD chemotactic sensory transduction; Region: CheD; cl00810 448385005894 GAF domain; Region: GAF_3; pfam13492 448385005895 Response regulator receiver domain; Region: Response_reg; pfam00072 448385005896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385005897 active site 448385005898 phosphorylation site [posttranslational modification] 448385005899 intermolecular recognition site; other site 448385005900 dimerization interface [polypeptide binding]; other site 448385005901 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 448385005902 Laminin-type epidermal growth factor-like domai; Region: EGF_Lam; smart00180 448385005903 Isochorismatase family; Region: Isochorismatase; pfam00857 448385005904 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 448385005905 catalytic triad [active] 448385005906 conserved cis-peptide bond; other site 448385005907 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 448385005908 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385005909 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 448385005910 C-terminal domain interface [polypeptide binding]; other site 448385005911 GSH binding site (G-site) [chemical binding]; other site 448385005912 dimer interface [polypeptide binding]; other site 448385005913 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 448385005914 dimer interface [polypeptide binding]; other site 448385005915 N-terminal domain interface [polypeptide binding]; other site 448385005916 substrate binding pocket (H-site) [chemical binding]; other site 448385005917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385005918 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 448385005919 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 448385005920 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385005921 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385005922 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385005923 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 448385005924 Peptidase family U32; Region: Peptidase_U32; pfam01136 448385005925 Collagenase; Region: DUF3656; pfam12392 448385005926 Peptidase family U32; Region: Peptidase_U32; cl03113 448385005927 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385005928 metal ion-dependent adhesion site (MIDAS); other site 448385005929 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 448385005930 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 448385005931 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 448385005932 putative ligand binding site [chemical binding]; other site 448385005933 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385005934 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385005935 Walker A/P-loop; other site 448385005936 ATP binding site [chemical binding]; other site 448385005937 Q-loop/lid; other site 448385005938 ABC transporter signature motif; other site 448385005939 Walker B; other site 448385005940 D-loop; other site 448385005941 H-loop/switch region; other site 448385005942 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385005943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385005944 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385005945 TM-ABC transporter signature motif; other site 448385005946 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385005947 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385005948 TM-ABC transporter signature motif; other site 448385005949 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385005950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385005951 NAD(P) binding site [chemical binding]; other site 448385005952 active site 448385005953 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 448385005954 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 448385005955 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 448385005956 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 448385005957 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 448385005958 shikimate binding site; other site 448385005959 NAD(P) binding site [chemical binding]; other site 448385005960 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 448385005961 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385005962 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385005963 putative active site [active] 448385005964 putative metal binding site [ion binding]; other site 448385005965 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 448385005966 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385005967 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 448385005968 nucleophilic elbow; other site 448385005969 catalytic triad; other site 448385005970 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 448385005971 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 448385005972 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 448385005973 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 448385005974 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385005975 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385005976 active site 448385005977 ATP binding site [chemical binding]; other site 448385005978 substrate binding site [chemical binding]; other site 448385005979 activation loop (A-loop); other site 448385005980 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385005981 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385005982 GAF domain; Region: GAF; cl17456 448385005983 GAF domain; Region: GAF_2; pfam13185 448385005984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385005985 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385005986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385005987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385005988 dimer interface [polypeptide binding]; other site 448385005989 phosphorylation site [posttranslational modification] 448385005990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385005991 ATP binding site [chemical binding]; other site 448385005992 Mg2+ binding site [ion binding]; other site 448385005993 G-X-G motif; other site 448385005995 Clp protease; Region: CLP_protease; pfam00574 448385005996 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 448385005997 oligomer interface [polypeptide binding]; other site 448385005998 active site residues [active] 448385005999 Cupin; Region: Cupin_6; pfam12852 448385006000 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385006001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385006002 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385006003 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 448385006004 active site 448385006005 catalytic residues [active] 448385006006 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 448385006007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385006008 Coenzyme A binding pocket [chemical binding]; other site 448385006009 SnoaL-like domain; Region: SnoaL_4; cl17707 448385006010 hypothetical protein; Provisional; Region: PRK06834 448385006011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385006012 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006013 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006014 phosphopeptide binding site; other site 448385006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385006016 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385006017 Walker A motif; other site 448385006018 ATP binding site [chemical binding]; other site 448385006019 Walker B motif; other site 448385006020 arginine finger; other site 448385006021 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385006022 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385006023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385006024 NAD(P) binding site [chemical binding]; other site 448385006025 active site 448385006026 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 448385006027 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 448385006028 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 448385006029 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 448385006030 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 448385006031 putative active site [active] 448385006032 putative dimer interface [polypeptide binding]; other site 448385006033 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 448385006034 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 448385006035 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 448385006036 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 448385006037 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 448385006038 active site 448385006039 ADP/pyrophosphate binding site [chemical binding]; other site 448385006040 dimerization interface [polypeptide binding]; other site 448385006041 allosteric effector site; other site 448385006042 fructose-1,6-bisphosphate binding site; other site 448385006043 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 448385006044 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 448385006045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385006046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006047 dimer interface [polypeptide binding]; other site 448385006048 phosphorylation site [posttranslational modification] 448385006049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006050 ATP binding site [chemical binding]; other site 448385006051 Mg2+ binding site [ion binding]; other site 448385006052 G-X-G motif; other site 448385006053 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385006054 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 448385006055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385006056 homodimer interface [polypeptide binding]; other site 448385006057 catalytic residue [active] 448385006058 putative amidase; Provisional; Region: PRK06169 448385006059 Amidase; Region: Amidase; cl11426 448385006060 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 448385006061 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 448385006062 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385006063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 448385006064 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385006065 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385006066 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385006067 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385006068 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385006069 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385006070 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 448385006071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385006072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385006073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385006074 dimerization interface [polypeptide binding]; other site 448385006075 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 448385006076 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 448385006077 NADP binding site [chemical binding]; other site 448385006078 dimer interface [polypeptide binding]; other site 448385006079 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 448385006080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385006081 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385006082 Walker A motif; other site 448385006083 ATP binding site [chemical binding]; other site 448385006084 Walker B motif; other site 448385006085 arginine finger; other site 448385006086 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385006087 CRM1 C terminal; Region: CRM1_C; cl07396 448385006088 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 448385006089 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 448385006090 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385006091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385006092 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385006093 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385006094 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385006095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385006096 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 448385006097 putative active site [active] 448385006098 putative metal binding site [ion binding]; other site 448385006099 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385006100 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385006101 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 448385006102 DNA binding residues [nucleotide binding] 448385006103 Methyltransferase domain; Region: Methyltransf_32; pfam13679 448385006104 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385006105 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385006106 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 448385006107 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 448385006108 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 448385006109 active site 448385006110 oxyanion hole [active] 448385006111 catalytic triad [active] 448385006112 TPR repeat; Region: TPR_11; pfam13414 448385006113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385006114 binding surface 448385006115 TPR motif; other site 448385006116 PEGA domain; Region: PEGA; pfam08308 448385006117 PEGA domain; Region: PEGA; pfam08308 448385006118 PEGA domain; Region: PEGA; pfam08308 448385006119 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385006120 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385006121 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385006122 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006123 active site 448385006124 ATP binding site [chemical binding]; other site 448385006125 substrate binding site [chemical binding]; other site 448385006126 activation loop (A-loop); other site 448385006127 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 448385006128 Predicted transporter component [General function prediction only]; Region: COG2391 448385006129 Sulphur transport; Region: Sulf_transp; pfam04143 448385006130 Amidohydrolase; Region: Amidohydro_2; pfam04909 448385006131 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 448385006132 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 448385006133 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 448385006135 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385006136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385006137 catalytic residue [active] 448385006138 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 448385006139 SmpB-tmRNA interface; other site 448385006140 PAS domain S-box; Region: sensory_box; TIGR00229 448385006141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385006142 putative active site [active] 448385006143 heme pocket [chemical binding]; other site 448385006144 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385006145 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 448385006146 GxxExxY protein; Region: GxxExxY; TIGR04256 448385006147 BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; Region: KU; cd00109 448385006148 trypsin interaction site; other site 448385006149 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 448385006150 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 448385006151 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 448385006152 Beta propeller domain; Region: Beta_propel; pfam09826 448385006153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006154 active site 448385006155 phosphorylation site [posttranslational modification] 448385006156 intermolecular recognition site; other site 448385006157 dimerization interface [polypeptide binding]; other site 448385006158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385006159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006160 dimer interface [polypeptide binding]; other site 448385006161 phosphorylation site [posttranslational modification] 448385006162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006163 ATP binding site [chemical binding]; other site 448385006164 Mg2+ binding site [ion binding]; other site 448385006165 G-X-G motif; other site 448385006166 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006168 active site 448385006169 ATP binding site [chemical binding]; other site 448385006170 substrate binding site [chemical binding]; other site 448385006171 activation loop (A-loop); other site 448385006172 Response regulator receiver domain; Region: Response_reg; pfam00072 448385006173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006174 active site 448385006175 phosphorylation site [posttranslational modification] 448385006176 intermolecular recognition site; other site 448385006177 dimerization interface [polypeptide binding]; other site 448385006178 Predicted ATPase [General function prediction only]; Region: COG3899 448385006179 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 448385006180 nudix motif; other site 448385006181 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 448385006182 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385006183 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 448385006184 Uncharacterized conserved protein [Function unknown]; Region: COG2968 448385006185 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385006186 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006187 active site 448385006188 ATP binding site [chemical binding]; other site 448385006189 substrate binding site [chemical binding]; other site 448385006190 activation loop (A-loop); other site 448385006191 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385006192 dimerization interface [polypeptide binding]; other site 448385006193 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385006194 ligand binding site [chemical binding]; other site 448385006195 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385006196 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385006197 Uncharacterized conserved protein [Function unknown]; Region: COG5439 448385006198 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 448385006199 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 448385006200 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385006201 mercuric reductase; Validated; Region: PRK06370 448385006202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385006203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 448385006204 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385006205 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 448385006206 active site 448385006207 motif I; other site 448385006208 motif II; other site 448385006209 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385006210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006212 active site 448385006213 ATP binding site [chemical binding]; other site 448385006214 substrate binding site [chemical binding]; other site 448385006215 activation loop (A-loop); other site 448385006216 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 448385006217 FOG: CBS domain [General function prediction only]; Region: COG0517 448385006218 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 448385006219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385006220 S-adenosylmethionine binding site [chemical binding]; other site 448385006221 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 448385006222 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 448385006223 Zn binding site [ion binding]; other site 448385006224 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385006225 putative active site [active] 448385006226 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 448385006227 substrate binding pocket [chemical binding]; other site 448385006228 active site 448385006229 Predicted permeases [General function prediction only]; Region: RarD; COG2962 448385006230 EamA-like transporter family; Region: EamA; cl17759 448385006231 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385006232 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385006233 catalytic residues [active] 448385006234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385006235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385006236 DNA binding residues [nucleotide binding] 448385006237 N-formylglutamate amidohydrolase; Region: FGase; cl01522 448385006238 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385006239 putative hydrophobic ligand binding site [chemical binding]; other site 448385006240 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 448385006241 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 448385006242 hypothetical protein; Provisional; Region: PRK09256 448385006243 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385006244 putative active site [active] 448385006245 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 448385006246 nudix motif; other site 448385006247 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 448385006248 catalytic triad [active] 448385006249 conserved cis-peptide bond; other site 448385006250 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 448385006251 Protein phosphatase 2C; Region: PP2C_2; pfam13672 448385006252 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 448385006253 nudix motif; other site 448385006254 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 448385006255 PAS fold; Region: PAS_4; pfam08448 448385006256 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385006257 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385006258 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 448385006259 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 448385006260 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385006261 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385006262 catalytic residues [active] 448385006263 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385006264 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 448385006265 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385006266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385006267 DNA binding residues [nucleotide binding] 448385006268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385006269 dimerization interface [polypeptide binding]; other site 448385006270 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385006271 ligand binding site [chemical binding]; other site 448385006272 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385006273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385006274 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 448385006275 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 448385006276 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 448385006277 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 448385006278 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 448385006279 putative hydrophobic ligand binding site [chemical binding]; other site 448385006280 protein interface [polypeptide binding]; other site 448385006281 gate; other site 448385006282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385006283 TPR motif; other site 448385006284 binding surface 448385006285 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 448385006286 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 448385006287 4-alpha-glucanotransferase; Provisional; Region: PRK14508 448385006288 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 448385006289 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 448385006290 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 448385006291 active site 448385006292 catalytic site [active] 448385006293 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006294 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006295 active site 448385006296 ATP binding site [chemical binding]; other site 448385006297 substrate binding site [chemical binding]; other site 448385006298 activation loop (A-loop); other site 448385006299 Predicted transcriptional regulators [Transcription]; Region: COG1733 448385006300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385006301 dimerization interface [polypeptide binding]; other site 448385006302 putative DNA binding site [nucleotide binding]; other site 448385006303 putative Zn2+ binding site [ion binding]; other site 448385006304 RibD C-terminal domain; Region: RibD_C; cl17279 448385006305 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 448385006306 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 448385006307 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 448385006308 metal binding site [ion binding]; metal-binding site 448385006309 putative dimer interface [polypeptide binding]; other site 448385006310 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 448385006311 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 448385006312 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 448385006313 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 448385006314 acyl-CoA synthetase; Validated; Region: PRK05850 448385006315 acyl-activating enzyme (AAE) consensus motif; other site 448385006316 active site 448385006317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385006318 Condensation domain; Region: Condensation; pfam00668 448385006319 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385006320 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385006321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385006322 acyl-activating enzyme (AAE) consensus motif; other site 448385006323 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 448385006324 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 448385006325 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 448385006326 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385006327 AMP binding site [chemical binding]; other site 448385006328 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385006329 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 448385006330 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385006331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385006332 acyl-activating enzyme (AAE) consensus motif; other site 448385006333 AMP binding site [chemical binding]; other site 448385006334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385006335 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 448385006336 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 448385006337 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 448385006338 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385006339 dimer interface [polypeptide binding]; other site 448385006340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385006341 catalytic residue [active] 448385006342 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385006343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 448385006344 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 448385006345 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 448385006346 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 448385006347 active site 448385006348 catalytic site [active] 448385006349 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 448385006350 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 448385006351 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 448385006352 catalytic site [active] 448385006353 active site 448385006354 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 448385006355 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 448385006356 homodimer interaction site [polypeptide binding]; other site 448385006357 cofactor binding site; other site 448385006358 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 448385006359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385006360 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 448385006361 Soluble P-type ATPase [General function prediction only]; Region: COG4087 448385006362 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 448385006363 carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369 448385006364 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385006365 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385006366 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 448385006367 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385006368 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385006369 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 448385006370 substrate binding site [chemical binding]; other site 448385006371 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 448385006372 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 448385006373 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 448385006374 catalytic site [active] 448385006375 subunit interface [polypeptide binding]; other site 448385006376 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 448385006377 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 448385006378 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 448385006379 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 448385006380 dimer interface [polypeptide binding]; other site 448385006381 putative functional site; other site 448385006382 putative MPT binding site; other site 448385006383 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 448385006384 MPT binding site; other site 448385006385 trimer interface [polypeptide binding]; other site 448385006386 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 448385006387 RNA recognition motif; Region: RRM; smart00360 448385006388 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 448385006389 RNA recognition motif; Region: RRM; smart00360 448385006390 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 448385006391 rod shape-determining protein MreB; Provisional; Region: PRK13927 448385006392 MreB and similar proteins; Region: MreB_like; cd10225 448385006393 nucleotide binding site [chemical binding]; other site 448385006394 Mg binding site [ion binding]; other site 448385006395 putative protofilament interaction site [polypeptide binding]; other site 448385006396 RodZ interaction site [polypeptide binding]; other site 448385006397 rod shape-determining protein MreC; Provisional; Region: PRK13922 448385006398 rod shape-determining protein MreC; Region: MreC; pfam04085 448385006399 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 448385006400 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 448385006401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 448385006402 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 448385006403 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 448385006404 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 448385006405 G1 box; other site 448385006406 GTP/Mg2+ binding site [chemical binding]; other site 448385006407 G2 box; other site 448385006408 Switch I region; other site 448385006409 G3 box; other site 448385006410 Switch II region; other site 448385006411 G4 box; other site 448385006412 G5 box; other site 448385006413 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 448385006414 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 448385006415 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385006416 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385006417 DNA binding residues [nucleotide binding] 448385006418 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385006419 HSP70 interaction site [polypeptide binding]; other site 448385006420 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 448385006421 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 448385006422 nucleotide binding site [chemical binding]; other site 448385006423 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 448385006424 Zn binding site [ion binding]; other site 448385006425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385006427 active site 448385006428 phosphorylation site [posttranslational modification] 448385006429 intermolecular recognition site; other site 448385006430 dimerization interface [polypeptide binding]; other site 448385006431 Bacterial SH3 domain; Region: SH3_3; pfam08239 448385006432 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385006433 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385006434 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385006435 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 448385006436 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 448385006437 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 448385006438 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 448385006439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385006440 Walker A/P-loop; other site 448385006441 ATP binding site [chemical binding]; other site 448385006442 Q-loop/lid; other site 448385006443 ABC transporter signature motif; other site 448385006444 Walker B; other site 448385006445 D-loop; other site 448385006446 H-loop/switch region; other site 448385006447 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 448385006448 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385006449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006450 active site 448385006451 phosphorylation site [posttranslational modification] 448385006452 intermolecular recognition site; other site 448385006453 dimerization interface [polypeptide binding]; other site 448385006454 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385006455 DNA binding site [nucleotide binding] 448385006456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006457 dimer interface [polypeptide binding]; other site 448385006458 phosphorylation site [posttranslational modification] 448385006459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006460 ATP binding site [chemical binding]; other site 448385006461 Mg2+ binding site [ion binding]; other site 448385006462 G-X-G motif; other site 448385006463 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 448385006464 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 448385006465 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 448385006466 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 448385006467 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 448385006468 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 448385006469 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 448385006470 Family description; Region: VCBS; pfam13517 448385006471 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 448385006472 Family description; Region: VCBS; pfam13517 448385006473 FG-GAP repeat; Region: FG-GAP; cl15299 448385006474 Family description; Region: VCBS; pfam13517 448385006475 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 448385006476 Family description; Region: VCBS; pfam13517 448385006477 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 448385006478 FG-GAP repeat; Region: FG-GAP; cl15299 448385006479 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385006480 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385006481 ligand binding site [chemical binding]; other site 448385006482 Antistasin family; Region: Antistasin; pfam02822 448385006483 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 448385006484 active site 448385006485 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385006486 Predicted transcriptional regulator [Transcription]; Region: COG2378 448385006487 WYL domain; Region: WYL; pfam13280 448385006488 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 448385006489 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 448385006490 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 448385006491 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 448385006492 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385006493 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385006494 catalytic residue [active] 448385006495 arginine decarboxylase; Provisional; Region: PRK05354 448385006496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 448385006497 active site 448385006498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 448385006499 catalytic residues [active] 448385006500 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 448385006501 CcmB protein; Region: CcmB; cl17444 448385006502 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 448385006503 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 448385006504 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 448385006505 active site 448385006506 (T/H)XGH motif; other site 448385006507 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 448385006508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385006509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385006510 binding surface 448385006511 TPR motif; other site 448385006512 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385006513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385006514 Walker A motif; other site 448385006515 ATP binding site [chemical binding]; other site 448385006516 Walker B motif; other site 448385006517 arginine finger; other site 448385006518 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385006519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006520 phosphorylation site [posttranslational modification] 448385006521 dimer interface [polypeptide binding]; other site 448385006522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006523 ATP binding site [chemical binding]; other site 448385006524 Mg2+ binding site [ion binding]; other site 448385006525 G-X-G motif; other site 448385006526 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 448385006527 NAD(P) binding site [chemical binding]; other site 448385006528 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006529 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006530 phosphopeptide binding site; other site 448385006531 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385006532 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 448385006533 histidinol dehydrogenase; Region: hisD; TIGR00069 448385006534 NAD binding site [chemical binding]; other site 448385006535 dimerization interface [polypeptide binding]; other site 448385006536 product binding site; other site 448385006537 substrate binding site [chemical binding]; other site 448385006538 zinc binding site [ion binding]; other site 448385006539 catalytic residues [active] 448385006540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006542 active site 448385006543 ATP binding site [chemical binding]; other site 448385006544 substrate binding site [chemical binding]; other site 448385006545 activation loop (A-loop); other site 448385006546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385006547 active site 448385006548 Uncharacterized conserved protein [Function unknown]; Region: COG4850 448385006549 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385006550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385006551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006552 active site 448385006553 ATP binding site [chemical binding]; other site 448385006554 substrate binding site [chemical binding]; other site 448385006555 activation loop (A-loop); other site 448385006556 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385006557 Predicted ATPase [General function prediction only]; Region: COG3899 448385006558 AAA ATPase domain; Region: AAA_16; pfam13191 448385006559 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385006560 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 448385006561 CoA-transferase family III; Region: CoA_transf_3; pfam02515 448385006562 SCP-2 sterol transfer family; Region: SCP2; pfam02036 448385006563 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 448385006564 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 448385006565 generic binding surface II; other site 448385006566 generic binding surface I; other site 448385006567 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 448385006568 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 448385006569 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 448385006570 NAD(P) binding site [chemical binding]; other site 448385006571 shikimate binding site; other site 448385006572 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 448385006573 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 448385006574 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 448385006575 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006576 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006577 phosphopeptide binding site; other site 448385006578 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 448385006579 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 448385006580 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 448385006581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385006582 S-adenosylmethionine binding site [chemical binding]; other site 448385006583 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385006584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 448385006585 active site 448385006586 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385006587 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 448385006588 active site 448385006589 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 448385006590 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 448385006591 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385006592 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 448385006593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385006594 motif II; other site 448385006595 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 448385006596 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 448385006597 active site 448385006598 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 448385006599 homodimer interface [polypeptide binding]; other site 448385006600 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385006601 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385006602 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385006603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385006604 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 448385006605 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 448385006606 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 448385006607 regulatory protein interface [polypeptide binding]; other site 448385006608 active site 448385006609 regulatory phosphorylation site [posttranslational modification]; other site 448385006610 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 448385006611 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 448385006612 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385006613 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 448385006614 DAK2 domain; Region: Dak2; cl03685 448385006615 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 448385006616 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 448385006617 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 448385006618 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385006619 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385006620 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 448385006621 Domain of unknown function DUF21; Region: DUF21; pfam01595 448385006622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 448385006623 Transporter associated domain; Region: CorC_HlyC; smart01091 448385006624 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 448385006625 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 448385006626 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385006627 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385006628 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385006629 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385006630 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 448385006631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385006632 ATP binding site [chemical binding]; other site 448385006633 putative Mg++ binding site [ion binding]; other site 448385006634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385006635 nucleotide binding region [chemical binding]; other site 448385006636 ATP-binding site [chemical binding]; other site 448385006637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006638 active site 448385006639 phosphorylation site [posttranslational modification] 448385006640 intermolecular recognition site; other site 448385006641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385006642 PAS fold; Region: PAS_3; pfam08447 448385006643 putative active site [active] 448385006644 heme pocket [chemical binding]; other site 448385006645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385006646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006647 dimer interface [polypeptide binding]; other site 448385006648 phosphorylation site [posttranslational modification] 448385006649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006650 ATP binding site [chemical binding]; other site 448385006651 Mg2+ binding site [ion binding]; other site 448385006652 G-X-G motif; other site 448385006653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385006654 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 448385006655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385006656 active site 448385006657 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 448385006658 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 448385006659 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 448385006660 Ligand Binding Site [chemical binding]; other site 448385006661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385006662 Ligand Binding Site [chemical binding]; other site 448385006663 conjugal transfer protein TrbA; Provisional; Region: PRK13890 448385006664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385006665 non-specific DNA binding site [nucleotide binding]; other site 448385006666 salt bridge; other site 448385006667 sequence-specific DNA binding site [nucleotide binding]; other site 448385006668 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 448385006669 active site 448385006670 phosphorylation site [posttranslational modification] 448385006671 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 448385006672 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385006673 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385006674 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385006675 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385006676 FHA domain; Region: FHA; pfam00498 448385006677 phosphopeptide binding site; other site 448385006678 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006679 phosphopeptide binding site; other site 448385006680 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006681 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006682 phosphopeptide binding site; other site 448385006683 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 448385006684 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 448385006685 Walker A/P-loop; other site 448385006686 ATP binding site [chemical binding]; other site 448385006687 Q-loop/lid; other site 448385006688 ABC transporter signature motif; other site 448385006689 Walker B; other site 448385006690 D-loop; other site 448385006691 H-loop/switch region; other site 448385006692 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 448385006693 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 448385006694 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385006695 active site 448385006696 Protein phosphatase 2C; Region: PP2C; pfam00481 448385006697 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 448385006698 metal ion-dependent adhesion site (MIDAS); other site 448385006699 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006700 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006701 phosphopeptide binding site; other site 448385006702 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385006703 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385006704 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385006705 phosphopeptide binding site; other site 448385006706 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 448385006707 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 448385006708 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 448385006709 G-X-X-G motif; other site 448385006710 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 448385006711 RxxxH motif; other site 448385006712 membrane protein insertase; Provisional; Region: PRK01318 448385006713 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 448385006714 Haemolytic domain; Region: Haemolytic; pfam01809 448385006715 Ribonuclease P; Region: Ribonuclease_P; pfam00825 448385006716 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 448385006717 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385006718 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385006719 ligand binding site [chemical binding]; other site 448385006720 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 448385006721 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 448385006722 catalytic residues [active] 448385006723 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 448385006724 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 448385006725 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 448385006726 dimer interface [polypeptide binding]; other site 448385006727 active site 448385006728 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 448385006729 dinuclear metal binding motif [ion binding]; other site 448385006730 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 448385006731 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 448385006732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385006733 S-adenosylmethionine binding site [chemical binding]; other site 448385006734 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 448385006735 acyl-CoA synthetase; Validated; Region: PRK09192 448385006736 acyl-activating enzyme (AAE) consensus motif; other site 448385006737 active site 448385006738 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385006739 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385006740 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 448385006741 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 448385006742 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 448385006743 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 448385006744 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385006745 Walker A/P-loop; other site 448385006746 ATP binding site [chemical binding]; other site 448385006747 Q-loop/lid; other site 448385006748 ABC transporter signature motif; other site 448385006749 Walker B; other site 448385006750 D-loop; other site 448385006751 H-loop/switch region; other site 448385006752 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 448385006753 aspartate kinase; Reviewed; Region: PRK06635 448385006754 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 448385006755 putative nucleotide binding site [chemical binding]; other site 448385006756 putative catalytic residues [active] 448385006757 putative Mg ion binding site [ion binding]; other site 448385006758 putative aspartate binding site [chemical binding]; other site 448385006759 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 448385006760 putative allosteric regulatory site; other site 448385006761 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 448385006762 TROVE domain; Region: TROVE; pfam05731 448385006763 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385006764 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385006765 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385006766 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385006767 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 448385006768 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385006769 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 448385006770 Response regulator receiver domain; Region: Response_reg; pfam00072 448385006771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006772 active site 448385006773 phosphorylation site [posttranslational modification] 448385006774 intermolecular recognition site; other site 448385006775 dimerization interface [polypeptide binding]; other site 448385006776 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385006777 GAF domain; Region: GAF_3; pfam13492 448385006778 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 448385006779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385006780 Zn2+ binding site [ion binding]; other site 448385006781 Mg2+ binding site [ion binding]; other site 448385006782 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 448385006783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385006784 S-adenosylmethionine binding site [chemical binding]; other site 448385006785 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 448385006786 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385006787 active site 448385006788 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 448385006789 putative iron binding site [ion binding]; other site 448385006790 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 448385006791 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 448385006792 NAD(P) binding site [chemical binding]; other site 448385006793 catalytic residues [active] 448385006794 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 448385006795 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 448385006796 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 448385006797 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 448385006798 catalytic residue [active] 448385006799 putative FPP diphosphate binding site; other site 448385006800 putative FPP binding hydrophobic cleft; other site 448385006801 dimer interface [polypeptide binding]; other site 448385006802 putative IPP diphosphate binding site; other site 448385006803 HAMP domain; Region: HAMP; pfam00672 448385006804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385006805 dimer interface [polypeptide binding]; other site 448385006806 phosphorylation site [posttranslational modification] 448385006807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385006808 ATP binding site [chemical binding]; other site 448385006809 Mg2+ binding site [ion binding]; other site 448385006810 G-X-G motif; other site 448385006811 DNA-binding response regulator CreB; Provisional; Region: PRK11083 448385006812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006813 active site 448385006814 phosphorylation site [posttranslational modification] 448385006815 intermolecular recognition site; other site 448385006816 dimerization interface [polypeptide binding]; other site 448385006817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385006818 DNA binding site [nucleotide binding] 448385006819 TPR repeat; Region: TPR_11; pfam13414 448385006820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385006821 TPR motif; other site 448385006822 binding surface 448385006823 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385006824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385006825 active site 448385006826 phosphorylation site [posttranslational modification] 448385006827 intermolecular recognition site; other site 448385006828 dimerization interface [polypeptide binding]; other site 448385006829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385006830 Walker A motif; other site 448385006831 ATP binding site [chemical binding]; other site 448385006832 Walker B motif; other site 448385006833 arginine finger; other site 448385006834 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385006835 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385006836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385006837 Q-loop/lid; other site 448385006838 ABC transporter signature motif; other site 448385006839 Walker B; other site 448385006840 D-loop; other site 448385006841 H-loop/switch region; other site 448385006842 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385006843 Domain of unknown function (DUF362); Region: DUF362; pfam04015 448385006844 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 448385006845 SmpB-tmRNA interface; other site 448385006846 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 448385006847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385006848 Walker A/P-loop; other site 448385006849 ATP binding site [chemical binding]; other site 448385006850 Q-loop/lid; other site 448385006851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385006852 ABC transporter signature motif; other site 448385006853 Walker B; other site 448385006854 D-loop; other site 448385006855 H-loop/switch region; other site 448385006856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385006857 Walker A/P-loop; other site 448385006858 ATP binding site [chemical binding]; other site 448385006859 Q-loop/lid; other site 448385006860 ABC transporter signature motif; other site 448385006861 Walker B; other site 448385006862 D-loop; other site 448385006863 H-loop/switch region; other site 448385006864 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385006865 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 448385006866 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385006867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385006868 Walker A/P-loop; other site 448385006869 ATP binding site [chemical binding]; other site 448385006870 Q-loop/lid; other site 448385006871 ABC transporter signature motif; other site 448385006872 Walker B; other site 448385006873 D-loop; other site 448385006874 H-loop/switch region; other site 448385006875 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 448385006876 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385006877 active site 448385006878 ATP binding site [chemical binding]; other site 448385006879 substrate binding site [chemical binding]; other site 448385006880 activation loop (A-loop); other site 448385006881 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 448385006882 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 448385006883 dimerization interface [polypeptide binding]; other site 448385006884 active site 448385006885 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 448385006886 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 448385006887 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 448385006888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385006889 FeS/SAM binding site; other site 448385006890 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 448385006891 AMP binding site [chemical binding]; other site 448385006892 metal binding site [ion binding]; metal-binding site 448385006893 active site 448385006894 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 448385006895 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 448385006896 putative active site; other site 448385006897 catalytic residue [active] 448385006898 multifunctional aminopeptidase A; Provisional; Region: PRK00913 448385006899 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 448385006900 interface (dimer of trimers) [polypeptide binding]; other site 448385006901 Substrate-binding/catalytic site; other site 448385006902 Zn-binding sites [ion binding]; other site 448385006903 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 448385006904 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 448385006905 Ligand Binding Site [chemical binding]; other site 448385006906 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 448385006907 Transglycosylase; Region: Transgly; pfam00912 448385006908 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 448385006909 nucleoside/Zn binding site; other site 448385006910 dimer interface [polypeptide binding]; other site 448385006911 catalytic motif [active] 448385006912 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385006913 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385006914 catalytic residues [active] 448385006915 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 448385006916 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 448385006917 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 448385006918 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 448385006919 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 448385006920 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 448385006921 active site 448385006922 catalytic triad [active] 448385006923 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 448385006924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385006925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385006926 homodimer interface [polypeptide binding]; other site 448385006927 catalytic residue [active] 448385006928 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385006929 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 448385006930 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 448385006931 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385006932 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 448385006933 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 448385006934 dimer interface [polypeptide binding]; other site 448385006935 active site 448385006936 CoA binding pocket [chemical binding]; other site 448385006937 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 448385006938 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 448385006939 Hydrogenase formation hypA family; Region: HypD; cl12072 448385006940 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 448385006941 short chain dehydrogenase; Provisional; Region: PRK06179 448385006942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385006943 NAD(P) binding site [chemical binding]; other site 448385006944 active site 448385006945 Cytochrome c; Region: Cytochrom_C; cl11414 448385006946 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385006947 classical (c) SDRs; Region: SDR_c; cd05233 448385006948 NAD(P) binding site [chemical binding]; other site 448385006949 active site 448385006950 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385006951 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385006952 active site 448385006953 catalytic tetrad [active] 448385006954 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 448385006955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385006956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385006957 DNA binding residues [nucleotide binding] 448385006958 conserved hypothetical protein; Region: MG423; TIGR00649 448385006959 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385006960 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 448385006961 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 448385006962 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 448385006963 anti sigma factor interaction site; other site 448385006964 regulatory phosphorylation site [posttranslational modification]; other site 448385006965 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 448385006966 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385006967 dimerization interface [polypeptide binding]; other site 448385006968 ligand binding site [chemical binding]; other site 448385006969 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385006970 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385006971 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 448385006972 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 448385006973 Na binding site [ion binding]; other site 448385006974 Protein of unknown function (DUF917); Region: DUF917; pfam06032 448385006975 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 448385006976 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 448385006977 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 448385006978 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 448385006979 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 448385006980 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 448385006981 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 448385006982 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 448385006983 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 448385006984 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 448385006985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385006986 Walker A motif; other site 448385006987 ATP binding site [chemical binding]; other site 448385006988 Walker B motif; other site 448385006989 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 448385006990 recombinase A; Provisional; Region: recA; PRK09354 448385006991 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 448385006992 hexamer interface [polypeptide binding]; other site 448385006993 Walker A motif; other site 448385006994 ATP binding site [chemical binding]; other site 448385006995 Walker B motif; other site 448385006996 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 448385006997 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 448385006998 dimer interface [polypeptide binding]; other site 448385006999 ssDNA binding site [nucleotide binding]; other site 448385007000 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385007001 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385007002 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 448385007003 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 448385007004 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385007005 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385007006 dinuclear metal binding motif [ion binding]; other site 448385007007 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 448385007008 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 448385007009 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385007010 ATP binding site [chemical binding]; other site 448385007011 putative Mg++ binding site [ion binding]; other site 448385007012 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385007013 nucleotide binding region [chemical binding]; other site 448385007014 ATP-binding site [chemical binding]; other site 448385007015 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 448385007016 Transposase IS200 like; Region: Y1_Tnp; cl00848 448385007017 NHL repeat; Region: NHL; pfam01436 448385007018 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385007019 NHL repeat; Region: NHL; pfam01436 448385007020 NHL repeat; Region: NHL; pfam01436 448385007021 WHG domain; Region: WHG; pfam13305 448385007022 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 448385007023 Asp-box motif; other site 448385007024 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385007025 Disintegrin; Region: Disintegrin; cl10507 448385007026 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385007027 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 448385007028 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 448385007029 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 448385007030 iron-sulfur cluster [ion binding]; other site 448385007031 [2Fe-2S] cluster binding site [ion binding]; other site 448385007032 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 448385007033 active site 448385007034 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 448385007035 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385007036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385007037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385007038 Walker A/P-loop; other site 448385007039 ATP binding site [chemical binding]; other site 448385007040 Q-loop/lid; other site 448385007041 ABC transporter signature motif; other site 448385007042 Walker B; other site 448385007043 D-loop; other site 448385007044 H-loop/switch region; other site 448385007045 PAS fold; Region: PAS_4; pfam08448 448385007046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007048 dimer interface [polypeptide binding]; other site 448385007049 phosphorylation site [posttranslational modification] 448385007050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007051 ATP binding site [chemical binding]; other site 448385007052 Mg2+ binding site [ion binding]; other site 448385007053 G-X-G motif; other site 448385007054 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007056 active site 448385007057 phosphorylation site [posttranslational modification] 448385007058 intermolecular recognition site; other site 448385007059 dimerization interface [polypeptide binding]; other site 448385007060 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385007061 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385007062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007064 dimer interface [polypeptide binding]; other site 448385007065 phosphorylation site [posttranslational modification] 448385007066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007067 ATP binding site [chemical binding]; other site 448385007068 Mg2+ binding site [ion binding]; other site 448385007069 G-X-G motif; other site 448385007070 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007072 active site 448385007073 phosphorylation site [posttranslational modification] 448385007074 intermolecular recognition site; other site 448385007075 dimerization interface [polypeptide binding]; other site 448385007076 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385007077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007078 active site 448385007079 phosphorylation site [posttranslational modification] 448385007080 intermolecular recognition site; other site 448385007081 dimerization interface [polypeptide binding]; other site 448385007082 PAS domain S-box; Region: sensory_box; TIGR00229 448385007083 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385007084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007085 putative active site [active] 448385007086 heme pocket [chemical binding]; other site 448385007087 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007088 dimer interface [polypeptide binding]; other site 448385007089 phosphorylation site [posttranslational modification] 448385007090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007091 ATP binding site [chemical binding]; other site 448385007092 Mg2+ binding site [ion binding]; other site 448385007093 G-X-G motif; other site 448385007094 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007096 active site 448385007097 phosphorylation site [posttranslational modification] 448385007098 intermolecular recognition site; other site 448385007099 dimerization interface [polypeptide binding]; other site 448385007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385007102 active site 448385007103 phosphorylation site [posttranslational modification] 448385007104 intermolecular recognition site; other site 448385007105 dimerization interface [polypeptide binding]; other site 448385007106 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385007107 putative binding surface; other site 448385007108 active site 448385007109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007110 ATP binding site [chemical binding]; other site 448385007111 Mg2+ binding site [ion binding]; other site 448385007112 G-X-G motif; other site 448385007113 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 448385007114 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 448385007115 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 448385007116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 448385007117 dimer interface [polypeptide binding]; other site 448385007118 putative CheW interface [polypeptide binding]; other site 448385007119 HEAT repeats; Region: HEAT_2; pfam13646 448385007120 HEAT repeats; Region: HEAT_2; pfam13646 448385007121 HEAT repeats; Region: HEAT_2; pfam13646 448385007122 HEAT repeats; Region: HEAT_2; pfam13646 448385007123 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 448385007124 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385007125 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 448385007126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007127 active site 448385007128 phosphorylation site [posttranslational modification] 448385007129 intermolecular recognition site; other site 448385007130 dimerization interface [polypeptide binding]; other site 448385007131 CheB methylesterase; Region: CheB_methylest; pfam01339 448385007132 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 448385007133 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 448385007134 putative DNA binding site [nucleotide binding]; other site 448385007135 putative homodimer interface [polypeptide binding]; other site 448385007136 Isochorismatase family; Region: Isochorismatase; pfam00857 448385007137 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 448385007138 catalytic triad [active] 448385007139 conserved cis-peptide bond; other site 448385007140 BON domain; Region: BON; pfam04972 448385007141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007142 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007143 active site 448385007144 ATP binding site [chemical binding]; other site 448385007145 substrate binding site [chemical binding]; other site 448385007146 activation loop (A-loop); other site 448385007147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385007148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385007149 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385007150 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385007151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007152 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385007153 Walker A motif; other site 448385007154 ATP binding site [chemical binding]; other site 448385007155 Walker B motif; other site 448385007156 arginine finger; other site 448385007157 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 448385007158 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385007159 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 448385007160 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 448385007161 SWIM zinc finger; Region: SWIM; pfam04434 448385007162 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 448385007163 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385007164 putative active site [active] 448385007165 putative NTP binding site [chemical binding]; other site 448385007166 putative nucleic acid binding site [nucleotide binding]; other site 448385007167 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007168 active site 448385007169 ATP binding site [chemical binding]; other site 448385007170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007171 substrate binding site [chemical binding]; other site 448385007172 activation loop (A-loop); other site 448385007173 Predicted ATPase [General function prediction only]; Region: COG3899 448385007174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007175 Walker A motif; other site 448385007176 ATP binding site [chemical binding]; other site 448385007177 Walker B motif; other site 448385007178 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385007179 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385007180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007182 ATP binding site [chemical binding]; other site 448385007183 Mg2+ binding site [ion binding]; other site 448385007184 G-X-G motif; other site 448385007185 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007187 active site 448385007188 phosphorylation site [posttranslational modification] 448385007189 intermolecular recognition site; other site 448385007190 dimerization interface [polypeptide binding]; other site 448385007191 PAS fold; Region: PAS_4; pfam08448 448385007192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007193 PAS domain; Region: PAS_9; pfam13426 448385007194 putative active site [active] 448385007195 heme pocket [chemical binding]; other site 448385007196 PAS domain S-box; Region: sensory_box; TIGR00229 448385007197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007198 putative active site [active] 448385007199 heme pocket [chemical binding]; other site 448385007200 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 448385007201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007202 dimer interface [polypeptide binding]; other site 448385007203 phosphorylation site [posttranslational modification] 448385007204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007205 ATP binding site [chemical binding]; other site 448385007206 Mg2+ binding site [ion binding]; other site 448385007207 G-X-G motif; other site 448385007208 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007209 PAS fold; Region: PAS_3; pfam08447 448385007210 putative active site [active] 448385007211 heme pocket [chemical binding]; other site 448385007212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007214 putative active site [active] 448385007215 heme pocket [chemical binding]; other site 448385007216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007217 dimer interface [polypeptide binding]; other site 448385007218 phosphorylation site [posttranslational modification] 448385007219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007220 ATP binding site [chemical binding]; other site 448385007221 Mg2+ binding site [ion binding]; other site 448385007222 G-X-G motif; other site 448385007223 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007225 active site 448385007226 phosphorylation site [posttranslational modification] 448385007227 intermolecular recognition site; other site 448385007228 dimerization interface [polypeptide binding]; other site 448385007229 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 448385007230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385007231 Beta-propeller repeat; Region: SBBP; pfam06739 448385007232 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385007233 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385007234 CoA binding domain; Region: CoA_binding; cl17356 448385007235 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 448385007236 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 448385007237 putative active site [active] 448385007238 putative metal binding site [ion binding]; other site 448385007239 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385007240 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 448385007241 active site 448385007242 catalytic triad [active] 448385007243 dimer interface [polypeptide binding]; other site 448385007244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007245 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385007246 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007247 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385007248 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385007249 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385007250 structural tetrad; other site 448385007251 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385007252 structural tetrad; other site 448385007253 WD40 repeats; Region: WD40; smart00320 448385007254 AAA ATPase domain; Region: AAA_16; pfam13191 448385007255 AAA domain; Region: AAA_22; pfam13401 448385007256 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385007257 S-adenosylmethionine binding site [chemical binding]; other site 448385007258 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385007259 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385007260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385007261 S-adenosylmethionine binding site [chemical binding]; other site 448385007262 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 448385007263 active site 448385007264 catalytic triad [active] 448385007265 oxyanion hole [active] 448385007266 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385007267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007268 active site 448385007269 phosphorylation site [posttranslational modification] 448385007270 intermolecular recognition site; other site 448385007271 dimerization interface [polypeptide binding]; other site 448385007272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007273 Walker A motif; other site 448385007274 ATP binding site [chemical binding]; other site 448385007275 Walker B motif; other site 448385007276 arginine finger; other site 448385007277 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 448385007278 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 448385007279 active site 448385007280 PAS domain S-box; Region: sensory_box; TIGR00229 448385007281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007282 putative active site [active] 448385007283 heme pocket [chemical binding]; other site 448385007284 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385007285 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 448385007286 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385007287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385007288 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385007289 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385007290 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385007291 Uncharacterized conserved protein [Function unknown]; Region: COG4104 448385007292 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385007293 phosphopeptide binding site; other site 448385007294 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 448385007295 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385007296 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 448385007297 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 448385007298 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 448385007299 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 448385007300 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385007302 S-adenosylmethionine binding site [chemical binding]; other site 448385007303 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 448385007304 putative active site [active] 448385007305 Zn binding site [ion binding]; other site 448385007306 PAS fold; Region: PAS_4; pfam08448 448385007307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007308 putative active site [active] 448385007309 heme pocket [chemical binding]; other site 448385007310 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385007311 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 448385007312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385007313 dimer interface [polypeptide binding]; other site 448385007314 substrate binding site [chemical binding]; other site 448385007315 metal binding site [ion binding]; metal-binding site 448385007316 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 448385007317 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 448385007318 active site 448385007319 substrate binding site [chemical binding]; other site 448385007320 coenzyme B12 binding site [chemical binding]; other site 448385007321 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 448385007322 B12 binding site [chemical binding]; other site 448385007323 cobalt ligand [ion binding]; other site 448385007324 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 448385007325 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 448385007326 Walker A; other site 448385007327 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385007328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007329 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385007330 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007331 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007332 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385007333 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007334 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007335 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385007336 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007337 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007338 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385007339 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007340 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385007343 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385007344 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385007345 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 448385007346 Active site serine [active] 448385007347 DTW domain; Region: DTW; cl01221 448385007348 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 448385007349 putative active site [active] 448385007350 putative substrate binding site [chemical binding]; other site 448385007351 Phosphotransferase enzyme family; Region: APH; pfam01636 448385007352 ATP binding site [chemical binding]; other site 448385007353 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 448385007354 PAS domain; Region: PAS; smart00091 448385007355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007356 dimer interface [polypeptide binding]; other site 448385007357 phosphorylation site [posttranslational modification] 448385007358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007359 ATP binding site [chemical binding]; other site 448385007360 Mg2+ binding site [ion binding]; other site 448385007361 G-X-G motif; other site 448385007362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385007363 metabolite-proton symporter; Region: 2A0106; TIGR00883 448385007364 putative substrate translocation pore; other site 448385007365 CBD_II domain; Region: CBD_II; smart00637 448385007366 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 448385007367 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 448385007368 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007369 active site 448385007370 ATP binding site [chemical binding]; other site 448385007371 substrate binding site [chemical binding]; other site 448385007372 activation loop (A-loop); other site 448385007373 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385007374 cyclase homology domain; Region: CHD; cd07302 448385007375 nucleotidyl binding site; other site 448385007376 metal binding site [ion binding]; metal-binding site 448385007377 dimer interface [polypeptide binding]; other site 448385007378 AAA ATPase domain; Region: AAA_16; pfam13191 448385007379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385007380 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007381 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007382 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007383 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007384 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 448385007385 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 448385007386 active site 448385007387 metal binding site [ion binding]; metal-binding site 448385007388 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 448385007389 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 448385007390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385007391 S-adenosylmethionine binding site [chemical binding]; other site 448385007392 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385007393 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 448385007394 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385007395 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 448385007396 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385007397 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385007398 catalytic residues [active] 448385007399 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385007400 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 448385007401 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385007402 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385007403 putative sugar binding sites [chemical binding]; other site 448385007404 Q-X-W motif; other site 448385007405 FecR protein; Region: FecR; pfam04773 448385007406 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385007407 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385007408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385007409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385007410 DNA binding residues [nucleotide binding] 448385007411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007412 active site 448385007413 ATP binding site [chemical binding]; other site 448385007414 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007415 substrate binding site [chemical binding]; other site 448385007416 activation loop (A-loop); other site 448385007417 AAA ATPase domain; Region: AAA_16; pfam13191 448385007418 Predicted ATPase [General function prediction only]; Region: COG3899 448385007419 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385007420 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385007421 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385007422 PilZ domain; Region: PilZ; pfam07238 448385007423 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385007424 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385007425 active site 448385007426 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 448385007427 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 448385007428 active site 448385007429 nucleophile elbow; other site 448385007430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007431 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385007432 active site 448385007433 ATP binding site [chemical binding]; other site 448385007434 substrate binding site [chemical binding]; other site 448385007435 activation loop (A-loop); other site 448385007436 AAA ATPase domain; Region: AAA_16; pfam13191 448385007437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385007438 putative oxidoreductase; Provisional; Region: PRK08275 448385007439 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 448385007440 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 448385007441 HEAT repeats; Region: HEAT_2; pfam13646 448385007442 HEAT repeats; Region: HEAT_2; pfam13646 448385007443 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 448385007444 protein binding surface [polypeptide binding]; other site 448385007445 HEAT repeats; Region: HEAT_2; pfam13646 448385007446 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385007447 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385007448 substrate binding pocket [chemical binding]; other site 448385007449 membrane-bound complex binding site; other site 448385007450 NosL; Region: NosL; cl01769 448385007451 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385007452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385007453 putative PBP binding loops; other site 448385007454 ABC-ATPase subunit interface; other site 448385007455 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385007456 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385007457 Walker A/P-loop; other site 448385007458 ATP binding site [chemical binding]; other site 448385007459 Q-loop/lid; other site 448385007460 ABC transporter signature motif; other site 448385007461 Walker B; other site 448385007462 D-loop; other site 448385007463 H-loop/switch region; other site 448385007464 Predicted membrane protein [Function unknown]; Region: COG2259 448385007465 PAS domain S-box; Region: sensory_box; TIGR00229 448385007466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007467 putative active site [active] 448385007468 heme pocket [chemical binding]; other site 448385007469 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385007470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007471 putative active site [active] 448385007472 heme pocket [chemical binding]; other site 448385007473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385007474 dimer interface [polypeptide binding]; other site 448385007475 phosphorylation site [posttranslational modification] 448385007476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007477 ATP binding site [chemical binding]; other site 448385007478 Mg2+ binding site [ion binding]; other site 448385007479 G-X-G motif; other site 448385007480 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 448385007481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007482 Walker A motif; other site 448385007483 ATP binding site [chemical binding]; other site 448385007484 Walker B motif; other site 448385007485 arginine finger; other site 448385007486 Peptidase family M41; Region: Peptidase_M41; pfam01434 448385007487 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385007488 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 448385007489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385007490 Coenzyme A binding pocket [chemical binding]; other site 448385007491 serine/threonine protein kinase; Provisional; Region: PRK11768 448385007492 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 448385007493 tellurium resistance terB-like protein; Region: terB_like; cd07177 448385007494 metal binding site [ion binding]; metal-binding site 448385007495 Protein kinase domain; Region: Pkinase; pfam00069 448385007496 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007497 active site 448385007498 ATP binding site [chemical binding]; other site 448385007499 substrate binding site [chemical binding]; other site 448385007500 activation loop (A-loop); other site 448385007501 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 448385007502 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 448385007503 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 448385007504 substrate binding site [chemical binding]; other site 448385007505 catalytic Zn binding site [ion binding]; other site 448385007506 NAD binding site [chemical binding]; other site 448385007507 structural Zn binding site [ion binding]; other site 448385007508 dimer interface [polypeptide binding]; other site 448385007509 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 448385007510 interface (dimer of trimers) [polypeptide binding]; other site 448385007511 Substrate-binding/catalytic site; other site 448385007512 Zn-binding sites [ion binding]; other site 448385007513 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 448385007514 hydrophobic ligand binding site; other site 448385007515 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007516 Right handed beta helix region; Region: Beta_helix; pfam13229 448385007517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385007518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385007519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385007520 dimerization interface [polypeptide binding]; other site 448385007521 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385007522 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 448385007523 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 448385007524 DNA adenine methylase (dam); Region: dam; TIGR00571 448385007525 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 448385007526 nudix motif; other site 448385007527 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 448385007528 oligomerisation interface [polypeptide binding]; other site 448385007529 mobile loop; other site 448385007530 roof hairpin; other site 448385007531 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 448385007532 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 448385007533 ring oligomerisation interface [polypeptide binding]; other site 448385007534 ATP/Mg binding site [chemical binding]; other site 448385007535 stacking interactions; other site 448385007536 hinge regions; other site 448385007537 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385007538 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385007539 ligand binding site [chemical binding]; other site 448385007540 flexible hinge region; other site 448385007541 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 448385007542 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385007543 Protein phosphatase 2C; Region: PP2C; pfam00481 448385007544 active site 448385007545 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 448385007546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385007547 spermidine synthase; Provisional; Region: PRK03612 448385007548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385007549 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 448385007550 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385007551 GAF domain; Region: GAF_2; pfam13185 448385007552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007554 ATP binding site [chemical binding]; other site 448385007555 Mg2+ binding site [ion binding]; other site 448385007556 G-X-G motif; other site 448385007557 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385007558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007559 active site 448385007560 phosphorylation site [posttranslational modification] 448385007561 intermolecular recognition site; other site 448385007562 dimerization interface [polypeptide binding]; other site 448385007563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007564 Walker A motif; other site 448385007565 ATP binding site [chemical binding]; other site 448385007566 Walker B motif; other site 448385007567 arginine finger; other site 448385007568 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385007569 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 448385007570 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 448385007571 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 448385007572 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 448385007573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385007574 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385007575 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007576 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007577 active site 448385007578 ATP binding site [chemical binding]; other site 448385007579 substrate binding site [chemical binding]; other site 448385007580 activation loop (A-loop); other site 448385007581 2TM domain; Region: 2TM; pfam13239 448385007582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385007583 AAA domain; Region: AAA_21; pfam13304 448385007584 Walker A/P-loop; other site 448385007585 ATP binding site [chemical binding]; other site 448385007586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385007587 Q-loop/lid; other site 448385007588 ABC transporter signature motif; other site 448385007589 Walker B; other site 448385007590 D-loop; other site 448385007591 H-loop/switch region; other site 448385007592 ATP-dependent helicase; Provisional; Region: PRK13767 448385007593 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385007594 ATP binding site [chemical binding]; other site 448385007595 putative Mg++ binding site [ion binding]; other site 448385007596 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385007597 nucleotide binding region [chemical binding]; other site 448385007598 ATP-binding site [chemical binding]; other site 448385007599 DEAD/H associated; Region: DEAD_assoc; pfam08494 448385007600 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385007601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385007602 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385007603 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385007604 Protein export membrane protein; Region: SecD_SecF; cl14618 448385007605 Protein of unknown function (DUF423); Region: DUF423; pfam04241 448385007606 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 448385007607 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 448385007608 motif 1; other site 448385007609 dimer interface [polypeptide binding]; other site 448385007610 active site 448385007611 motif 2; other site 448385007612 motif 3; other site 448385007613 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 448385007614 Zn binding site [ion binding]; other site 448385007615 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 448385007616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007617 TPR repeat; Region: TPR_11; pfam13414 448385007618 binding surface 448385007619 TPR motif; other site 448385007620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007621 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385007622 TPR motif; other site 448385007623 binding surface 448385007624 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 448385007625 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 448385007626 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 448385007627 catalytic residues [active] 448385007628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007629 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007630 active site 448385007631 ATP binding site [chemical binding]; other site 448385007632 substrate binding site [chemical binding]; other site 448385007633 activation loop (A-loop); other site 448385007634 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385007635 SIR2-like domain; Region: SIR2_2; pfam13289 448385007636 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 448385007637 putative active site [active] 448385007638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385007639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385007640 active site 448385007641 catalytic tetrad [active] 448385007642 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 448385007643 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385007644 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 448385007645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385007646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 448385007647 dimer interface [polypeptide binding]; other site 448385007648 phosphorylation site [posttranslational modification] 448385007649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385007650 ATP binding site [chemical binding]; other site 448385007651 Mg2+ binding site [ion binding]; other site 448385007652 G-X-G motif; other site 448385007653 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 448385007654 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 448385007655 putative active site [active] 448385007656 oxyanion strand; other site 448385007657 catalytic triad [active] 448385007658 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 448385007659 putative active site pocket [active] 448385007660 4-fold oligomerization interface [polypeptide binding]; other site 448385007661 metal binding residues [ion binding]; metal-binding site 448385007662 3-fold/trimer interface [polypeptide binding]; other site 448385007663 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007664 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007665 active site 448385007666 ATP binding site [chemical binding]; other site 448385007667 substrate binding site [chemical binding]; other site 448385007668 activation loop (A-loop); other site 448385007669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385007670 TPR repeat; Region: TPR_11; pfam13414 448385007671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007672 binding surface 448385007673 TPR motif; other site 448385007674 PEGA domain; Region: PEGA; pfam08308 448385007675 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 448385007676 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 448385007677 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385007678 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385007679 ligand binding site [chemical binding]; other site 448385007680 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007681 TPR repeat; Region: TPR_11; pfam13414 448385007682 binding surface 448385007683 TPR motif; other site 448385007684 PEGA domain; Region: PEGA; pfam08308 448385007685 PEGA domain; Region: PEGA; pfam08308 448385007686 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 448385007687 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 448385007688 Found in ATP-dependent protease La (LON); Region: LON; smart00464 448385007689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007690 Walker A motif; other site 448385007691 ATP binding site [chemical binding]; other site 448385007692 Walker B motif; other site 448385007693 arginine finger; other site 448385007694 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385007695 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 448385007696 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 448385007697 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 448385007698 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 448385007699 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 448385007700 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 448385007701 hydrophobic ligand binding site; other site 448385007702 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 448385007703 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 448385007704 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385007705 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385007706 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 448385007707 Response regulator receiver domain; Region: Response_reg; pfam00072 448385007708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007709 active site 448385007710 phosphorylation site [posttranslational modification] 448385007711 intermolecular recognition site; other site 448385007712 dimerization interface [polypeptide binding]; other site 448385007713 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385007714 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385007715 metal binding site [ion binding]; metal-binding site 448385007716 active site 448385007717 I-site; other site 448385007718 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385007719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007720 active site 448385007721 phosphorylation site [posttranslational modification] 448385007722 intermolecular recognition site; other site 448385007723 dimerization interface [polypeptide binding]; other site 448385007724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007725 Walker A motif; other site 448385007726 ATP binding site [chemical binding]; other site 448385007727 Walker B motif; other site 448385007728 arginine finger; other site 448385007729 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 448385007730 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 448385007731 Heme exporter protein D (CcmD); Region: CcmD; cl11475 448385007732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385007733 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385007734 active site 448385007735 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 448385007736 phosphopeptide binding site; other site 448385007737 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385007738 Protein phosphatase 2C; Region: PP2C; pfam00481 448385007739 active site 448385007740 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 448385007741 active site 448385007742 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 448385007743 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 448385007744 active site 448385007745 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385007746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385007747 catalytic residues [active] 448385007748 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 448385007749 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 448385007750 periplasmic chaperone; Provisional; Region: PRK10780 448385007751 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 448385007752 heterotetramer interface [polypeptide binding]; other site 448385007753 active site pocket [active] 448385007754 cleavage site 448385007755 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 448385007756 active site 448385007757 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385007758 Protein kinase domain; Region: Pkinase; pfam00069 448385007759 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007760 active site 448385007761 ATP binding site [chemical binding]; other site 448385007762 substrate binding site [chemical binding]; other site 448385007763 activation loop (A-loop); other site 448385007764 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 448385007765 ADP-ribose binding site [chemical binding]; other site 448385007766 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 448385007767 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 448385007768 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 448385007769 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385007770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385007771 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 448385007772 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 448385007773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385007774 motif II; other site 448385007775 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385007776 metal ion-dependent adhesion site (MIDAS); other site 448385007777 LNS2 (Lipin/Ned1/Smp2); Region: LNS2; pfam08235 448385007778 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 448385007779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385007780 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385007781 active site 448385007782 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385007783 serpin-like protein; Provisional; Region: PHA02660 448385007784 reactive center loop; other site 448385007785 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 448385007786 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 448385007787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385007788 catalytic residue [active] 448385007789 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385007790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385007791 active site 448385007792 phosphorylation site [posttranslational modification] 448385007793 intermolecular recognition site; other site 448385007794 dimerization interface [polypeptide binding]; other site 448385007795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007796 Walker A motif; other site 448385007797 ATP binding site [chemical binding]; other site 448385007798 Walker B motif; other site 448385007799 arginine finger; other site 448385007800 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385007801 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 448385007802 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 448385007803 putative active site [active] 448385007804 PhoH-like protein; Region: PhoH; pfam02562 448385007805 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 448385007806 ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614 448385007807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385007808 ATP binding site [chemical binding]; other site 448385007809 putative Mg++ binding site [ion binding]; other site 448385007810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385007811 nucleotide binding region [chemical binding]; other site 448385007812 ATP-binding site [chemical binding]; other site 448385007813 RQC domain; Region: RQC; pfam09382 448385007814 HRDC domain; Region: HRDC; pfam00570 448385007815 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 448385007816 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385007817 NAD binding site [chemical binding]; other site 448385007818 active site 448385007819 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 448385007820 nudix motif; other site 448385007821 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 448385007822 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 448385007823 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 448385007824 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385007825 B12 binding site [chemical binding]; other site 448385007826 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385007827 HSP70 interaction site [polypeptide binding]; other site 448385007828 short chain dehydrogenase; Provisional; Region: PRK07791 448385007829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385007830 NAD(P) binding site [chemical binding]; other site 448385007831 active site 448385007832 Gram-negative bacterial tonB protein; Region: TonB; cl10048 448385007833 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 448385007834 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385007835 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 448385007836 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 448385007837 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 448385007838 Cu(I) binding site [ion binding]; other site 448385007839 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385007840 active site 448385007841 ATP binding site [chemical binding]; other site 448385007842 substrate binding site [chemical binding]; other site 448385007843 activation loop (A-loop); other site 448385007844 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385007845 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385007846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385007847 Walker A motif; other site 448385007848 ATP binding site [chemical binding]; other site 448385007849 Walker B motif; other site 448385007850 arginine finger; other site 448385007851 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385007852 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 448385007853 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385007854 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385007855 phosphopeptide binding site; other site 448385007856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385007857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385007858 metal binding site [ion binding]; metal-binding site 448385007859 active site 448385007860 I-site; other site 448385007861 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 448385007862 heme-binding residues [chemical binding]; other site 448385007863 HEAT repeats; Region: HEAT_2; pfam13646 448385007864 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 448385007865 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 448385007866 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385007867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 448385007868 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 448385007869 tol-pal system protein YbgF; Provisional; Region: PRK10803 448385007870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 448385007871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007872 binding surface 448385007873 TPR motif; other site 448385007874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007875 TPR motif; other site 448385007876 binding surface 448385007877 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385007878 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385007879 phosphopeptide binding site; other site 448385007880 TPR repeat; Region: TPR_11; pfam13414 448385007881 TPR repeat; Region: TPR_11; pfam13414 448385007882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007883 binding surface 448385007884 TPR motif; other site 448385007885 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385007886 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385007887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007888 binding surface 448385007889 TPR motif; other site 448385007890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007891 TPR motif; other site 448385007892 binding surface 448385007893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007894 TPR motif; other site 448385007895 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385007896 binding surface 448385007897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007898 TPR motif; other site 448385007899 Tetratricopeptide repeat; Region: TPR_15; pfam13429 448385007900 binding surface 448385007901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007902 binding surface 448385007903 TPR motif; other site 448385007904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007905 binding surface 448385007906 TPR motif; other site 448385007907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007908 binding surface 448385007909 TPR motif; other site 448385007910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007911 TPR motif; other site 448385007912 binding surface 448385007913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007914 TPR motif; other site 448385007915 binding surface 448385007916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385007917 binding surface 448385007918 TPR motif; other site 448385007919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007921 active site 448385007922 ATP binding site [chemical binding]; other site 448385007923 substrate binding site [chemical binding]; other site 448385007924 activation loop (A-loop); other site 448385007925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007927 active site 448385007928 ATP binding site [chemical binding]; other site 448385007929 substrate binding site [chemical binding]; other site 448385007930 activation loop (A-loop); other site 448385007931 AAA ATPase domain; Region: AAA_16; pfam13191 448385007932 TPR repeat; Region: TPR_11; pfam13414 448385007933 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385007934 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385007935 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385007936 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385007937 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385007938 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385007939 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385007940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385007941 Protein kinase domain; Region: Pkinase; pfam00069 448385007942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007943 active site 448385007944 ATP binding site [chemical binding]; other site 448385007945 substrate binding site [chemical binding]; other site 448385007946 activation loop (A-loop); other site 448385007947 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385007948 cyclase homology domain; Region: CHD; cd07302 448385007949 nucleotidyl binding site; other site 448385007950 metal binding site [ion binding]; metal-binding site 448385007951 dimer interface [polypeptide binding]; other site 448385007952 AAA ATPase domain; Region: AAA_16; pfam13191 448385007953 AAA ATPase domain; Region: AAA_16; pfam13191 448385007954 PAS domain; Region: PAS_9; pfam13426 448385007955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007956 putative active site [active] 448385007957 heme pocket [chemical binding]; other site 448385007958 PAS domain S-box; Region: sensory_box; TIGR00229 448385007959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007960 putative active site [active] 448385007961 heme pocket [chemical binding]; other site 448385007962 PAS domain S-box; Region: sensory_box; TIGR00229 448385007963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007964 putative active site [active] 448385007965 heme pocket [chemical binding]; other site 448385007966 PAS domain; Region: PAS_9; pfam13426 448385007967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385007968 putative active site [active] 448385007969 heme pocket [chemical binding]; other site 448385007970 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385007971 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385007972 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385007973 active site 448385007974 ATP binding site [chemical binding]; other site 448385007975 substrate binding site [chemical binding]; other site 448385007976 activation loop (A-loop); other site 448385007977 AAA ATPase domain; Region: AAA_16; pfam13191 448385007978 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 448385007979 MoaE interaction surface [polypeptide binding]; other site 448385007980 MoeB interaction surface [polypeptide binding]; other site 448385007981 thiocarboxylated glycine; other site 448385007982 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 448385007983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385007984 FeS/SAM binding site; other site 448385007985 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 448385007986 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 448385007987 trimer interface [polypeptide binding]; other site 448385007988 dimer interface [polypeptide binding]; other site 448385007989 putative active site [active] 448385007990 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 448385007991 MoaE homodimer interface [polypeptide binding]; other site 448385007992 MoaD interaction [polypeptide binding]; other site 448385007993 active site residues [active] 448385007994 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 448385007995 PhoU domain; Region: PhoU; pfam01895 448385007996 PhoU domain; Region: PhoU; pfam01895 448385007997 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 448385007998 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 448385007999 Walker A/P-loop; other site 448385008000 ATP binding site [chemical binding]; other site 448385008001 Q-loop/lid; other site 448385008002 ABC transporter signature motif; other site 448385008003 Walker B; other site 448385008004 D-loop; other site 448385008005 H-loop/switch region; other site 448385008006 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 448385008007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385008008 dimer interface [polypeptide binding]; other site 448385008009 conserved gate region; other site 448385008010 putative PBP binding loops; other site 448385008011 ABC-ATPase subunit interface; other site 448385008012 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 448385008013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385008014 dimer interface [polypeptide binding]; other site 448385008015 conserved gate region; other site 448385008016 putative PBP binding loops; other site 448385008017 ABC-ATPase subunit interface; other site 448385008018 PBP superfamily domain; Region: PBP_like_2; cl17296 448385008019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385008020 dimerization interface [polypeptide binding]; other site 448385008021 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385008022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385008023 putative active site [active] 448385008024 heme pocket [chemical binding]; other site 448385008025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385008026 dimer interface [polypeptide binding]; other site 448385008027 phosphorylation site [posttranslational modification] 448385008028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385008029 ATP binding site [chemical binding]; other site 448385008030 Mg2+ binding site [ion binding]; other site 448385008031 G-X-G motif; other site 448385008032 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385008033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008034 active site 448385008035 phosphorylation site [posttranslational modification] 448385008036 intermolecular recognition site; other site 448385008037 dimerization interface [polypeptide binding]; other site 448385008038 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385008039 DNA binding site [nucleotide binding] 448385008040 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 448385008041 active site 448385008042 multimer interface [polypeptide binding]; other site 448385008043 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 448385008044 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 448385008045 putative trimer interface [polypeptide binding]; other site 448385008046 putative CoA binding site [chemical binding]; other site 448385008047 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 448385008048 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 448385008049 metal binding site [ion binding]; metal-binding site 448385008050 putative dimer interface [polypeptide binding]; other site 448385008051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385008052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385008053 dimer interface [polypeptide binding]; other site 448385008054 phosphorylation site [posttranslational modification] 448385008055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385008056 ATP binding site [chemical binding]; other site 448385008057 Mg2+ binding site [ion binding]; other site 448385008058 G-X-G motif; other site 448385008059 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385008060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008061 active site 448385008062 phosphorylation site [posttranslational modification] 448385008063 intermolecular recognition site; other site 448385008064 dimerization interface [polypeptide binding]; other site 448385008065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008066 active site 448385008067 phosphorylation site [posttranslational modification] 448385008068 intermolecular recognition site; other site 448385008069 dimerization interface [polypeptide binding]; other site 448385008070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385008071 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 448385008072 dimer interface [polypeptide binding]; other site 448385008073 phosphorylation site [posttranslational modification] 448385008074 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385008075 HEAT repeats; Region: HEAT_2; pfam13646 448385008076 HEAT repeats; Region: HEAT_2; pfam13646 448385008077 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385008078 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385008079 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385008080 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385008081 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385008082 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385008083 Protein kinase domain; Region: Pkinase; pfam00069 448385008084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008085 active site 448385008086 ATP binding site [chemical binding]; other site 448385008087 substrate binding site [chemical binding]; other site 448385008088 activation loop (A-loop); other site 448385008089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008091 active site 448385008092 ATP binding site [chemical binding]; other site 448385008093 substrate binding site [chemical binding]; other site 448385008094 activation loop (A-loop); other site 448385008095 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385008096 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 448385008097 short chain dehydrogenase; Validated; Region: PRK08324 448385008098 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 448385008099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385008100 NAD(P) binding site [chemical binding]; other site 448385008101 active site 448385008102 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 448385008103 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 448385008104 homotetramer interface [polypeptide binding]; other site 448385008105 ligand binding site [chemical binding]; other site 448385008106 catalytic site [active] 448385008107 NAD binding site [chemical binding]; other site 448385008108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 448385008109 putative DNA binding site [nucleotide binding]; other site 448385008110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008111 S-adenosylmethionine binding site [chemical binding]; other site 448385008112 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385008113 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385008114 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385008115 SurA N-terminal domain; Region: SurA_N_3; cl07813 448385008116 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 448385008117 PilZ domain; Region: PilZ; pfam07238 448385008118 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 448385008119 DEAD/DEAH box helicase; Region: DEAD; pfam00270 448385008120 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 448385008121 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 448385008122 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 448385008123 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385008124 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385008125 Response regulator receiver domain; Region: Response_reg; pfam00072 448385008126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008127 active site 448385008128 phosphorylation site [posttranslational modification] 448385008129 intermolecular recognition site; other site 448385008130 dimerization interface [polypeptide binding]; other site 448385008131 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385008132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008133 Walker A motif; other site 448385008134 ATP binding site [chemical binding]; other site 448385008135 Walker B motif; other site 448385008136 arginine finger; other site 448385008137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385008138 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 448385008139 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385008140 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 448385008141 putative GSH binding site [chemical binding]; other site 448385008142 catalytic residues [active] 448385008143 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 448385008144 Fe-S cluster binding site [ion binding]; other site 448385008145 DNA binding site [nucleotide binding] 448385008146 active site 448385008147 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 448385008148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385008149 active site 448385008150 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 448385008151 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 448385008152 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 448385008153 NAD(P) binding site [chemical binding]; other site 448385008154 catalytic residues [active] 448385008155 PEGA domain; Region: PEGA; pfam08308 448385008156 Cytochrome c; Region: Cytochrom_C; pfam00034 448385008157 Outer membrane efflux protein; Region: OEP; pfam02321 448385008158 Outer membrane efflux protein; Region: OEP; pfam02321 448385008159 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 448385008160 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 448385008161 SWIM zinc finger; Region: SWIM; pfam04434 448385008162 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 448385008163 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 448385008164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385008165 ATP binding site [chemical binding]; other site 448385008166 putative Mg++ binding site [ion binding]; other site 448385008167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385008168 nucleotide binding region [chemical binding]; other site 448385008169 ATP-binding site [chemical binding]; other site 448385008170 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385008171 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385008172 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385008173 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 448385008174 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 448385008175 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385008176 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385008177 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385008178 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 448385008179 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 448385008180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385008181 Zn2+ binding site [ion binding]; other site 448385008182 Mg2+ binding site [ion binding]; other site 448385008183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008185 active site 448385008186 ATP binding site [chemical binding]; other site 448385008187 substrate binding site [chemical binding]; other site 448385008188 activation loop (A-loop); other site 448385008189 DNA mismatch repair protein; Provisional; Region: PRK05070 448385008190 putative active site [active] 448385008191 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008192 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008193 active site 448385008194 ATP binding site [chemical binding]; other site 448385008195 substrate binding site [chemical binding]; other site 448385008196 activation loop (A-loop); other site 448385008197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385008198 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385008199 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385008200 active site 448385008201 metal binding site [ion binding]; metal-binding site 448385008202 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 448385008203 active site 448385008204 substrate-binding site [chemical binding]; other site 448385008205 metal-binding site [ion binding] 448385008206 GTP binding site [chemical binding]; other site 448385008207 Predicted transcriptional regulators [Transcription]; Region: COG1510 448385008208 MarR family; Region: MarR_2; cl17246 448385008209 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 448385008210 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 448385008211 substrate binding pocket [chemical binding]; other site 448385008212 chain length determination region; other site 448385008213 substrate-Mg2+ binding site; other site 448385008214 catalytic residues [active] 448385008215 aspartate-rich region 1; other site 448385008216 active site lid residues [active] 448385008217 aspartate-rich region 2; other site 448385008218 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 448385008219 homodimer interface [polypeptide binding]; other site 448385008220 catalytic residues [active] 448385008221 NAD binding site [chemical binding]; other site 448385008222 substrate binding pocket [chemical binding]; other site 448385008223 flexible flap; other site 448385008224 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 448385008225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008226 S-adenosylmethionine binding site [chemical binding]; other site 448385008227 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 448385008228 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 448385008229 dimer interface [polypeptide binding]; other site 448385008230 tetramer interface [polypeptide binding]; other site 448385008231 PYR/PP interface [polypeptide binding]; other site 448385008232 TPP binding site [chemical binding]; other site 448385008233 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 448385008234 TPP-binding site [chemical binding]; other site 448385008235 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 448385008236 UbiA prenyltransferase family; Region: UbiA; pfam01040 448385008237 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 448385008238 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 448385008239 metal binding site [ion binding]; metal-binding site 448385008240 substrate binding pocket [chemical binding]; other site 448385008241 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 448385008242 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 448385008243 acyl-activating enzyme (AAE) consensus motif; other site 448385008244 putative active site [active] 448385008245 putative AMP binding site [chemical binding]; other site 448385008246 putative CoA binding site [chemical binding]; other site 448385008247 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 448385008248 active site 448385008249 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 448385008250 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385008251 putative acyl-acceptor binding pocket; other site 448385008252 This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins; Region: LNS2; smart00775 448385008253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385008255 active site 448385008256 ATP binding site [chemical binding]; other site 448385008257 substrate binding site [chemical binding]; other site 448385008258 activation loop (A-loop); other site 448385008259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008260 binding surface 448385008261 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385008262 TPR motif; other site 448385008263 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 448385008264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385008265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385008266 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 448385008267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008268 active site 448385008269 phosphorylation site [posttranslational modification] 448385008270 intermolecular recognition site; other site 448385008271 dimerization interface [polypeptide binding]; other site 448385008272 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 448385008273 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385008274 active site 448385008275 ATP binding site [chemical binding]; other site 448385008276 substrate binding site [chemical binding]; other site 448385008277 activation loop (A-loop); other site 448385008278 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 448385008279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385008280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385008281 homodimer interface [polypeptide binding]; other site 448385008282 catalytic residue [active] 448385008283 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 448385008284 active site 448385008285 dimer interface [polypeptide binding]; other site 448385008286 catalytic nucleophile [active] 448385008287 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 448385008288 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 448385008289 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 448385008290 hinge; other site 448385008291 active site 448385008292 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385008293 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 448385008294 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 448385008295 dimer interface [polypeptide binding]; other site 448385008296 FMN binding site [chemical binding]; other site 448385008297 NADPH bind site [chemical binding]; other site 448385008298 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 448385008299 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 448385008300 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 448385008301 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 448385008302 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 448385008303 metal binding site [ion binding]; metal-binding site 448385008304 active site 448385008305 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 448385008306 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 448385008307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008308 S-adenosylmethionine binding site [chemical binding]; other site 448385008309 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 448385008310 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385008311 active site 448385008312 iron coordination sites [ion binding]; other site 448385008313 substrate binding pocket [chemical binding]; other site 448385008314 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 448385008315 Cytochrome c; Region: Cytochrom_C; pfam00034 448385008316 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 448385008317 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385008318 dinuclear metal binding motif [ion binding]; other site 448385008319 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385008320 active site 448385008321 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 448385008322 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 448385008323 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 448385008324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 448385008325 putative homodimer interface [polypeptide binding]; other site 448385008326 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 448385008327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385008328 UDP-galactopyranose mutase; Region: GLF; pfam03275 448385008329 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 448385008330 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 448385008331 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 448385008332 NADP binding site [chemical binding]; other site 448385008333 active site 448385008334 putative substrate binding site [chemical binding]; other site 448385008335 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 448385008336 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 448385008337 Walker A/P-loop; other site 448385008338 ATP binding site [chemical binding]; other site 448385008339 Q-loop/lid; other site 448385008340 ABC transporter signature motif; other site 448385008341 Walker B; other site 448385008342 D-loop; other site 448385008343 H-loop/switch region; other site 448385008344 TOBE domain; Region: TOBE_2; pfam08402 448385008345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 448385008346 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 448385008347 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 448385008348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 448385008349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385008350 dimer interface [polypeptide binding]; other site 448385008351 putative PBP binding loops; other site 448385008352 ABC-ATPase subunit interface; other site 448385008353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 448385008354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385008355 dimer interface [polypeptide binding]; other site 448385008356 conserved gate region; other site 448385008357 putative PBP binding loops; other site 448385008358 ABC-ATPase subunit interface; other site 448385008359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008360 TPR motif; other site 448385008361 binding surface 448385008362 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385008363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385008364 putative active site [active] 448385008365 heme pocket [chemical binding]; other site 448385008366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385008367 dimer interface [polypeptide binding]; other site 448385008368 phosphorylation site [posttranslational modification] 448385008369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385008370 ATP binding site [chemical binding]; other site 448385008371 Mg2+ binding site [ion binding]; other site 448385008372 G-X-G motif; other site 448385008373 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385008374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008375 active site 448385008376 phosphorylation site [posttranslational modification] 448385008377 intermolecular recognition site; other site 448385008378 dimerization interface [polypeptide binding]; other site 448385008379 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 448385008380 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 448385008381 active site 448385008382 catalytic site [active] 448385008383 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385008384 Cytochrome P450; Region: p450; cl12078 448385008385 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 448385008386 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 448385008387 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 448385008388 active site 448385008389 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; pfam10092 448385008390 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 448385008391 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 448385008392 putative active site [active] 448385008393 Protein of unknown function DUF99; Region: DUF99; pfam01949 448385008394 hypothetical protein; Provisional; Region: PRK00766 448385008395 GAF domain; Region: GAF_3; pfam13492 448385008396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385008397 dimer interface [polypeptide binding]; other site 448385008398 phosphorylation site [posttranslational modification] 448385008399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385008400 ATP binding site [chemical binding]; other site 448385008401 Mg2+ binding site [ion binding]; other site 448385008402 G-X-G motif; other site 448385008403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385008404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 448385008405 DNA binding site [nucleotide binding] 448385008406 domain linker motif; other site 448385008407 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 448385008408 ligand binding site [chemical binding]; other site 448385008409 dimerization interface (open form) [polypeptide binding]; other site 448385008410 dimerization interface (closed form) [polypeptide binding]; other site 448385008411 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385008412 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385008413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385008414 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 448385008415 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 448385008416 SLBB domain; Region: SLBB; pfam10531 448385008417 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 448385008418 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385008419 putative active site [active] 448385008420 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385008421 active site 448385008422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385008423 Coenzyme A binding pocket [chemical binding]; other site 448385008424 Predicted transcriptional regulators [Transcription]; Region: COG1695 448385008425 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 448385008426 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 448385008427 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 448385008428 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 448385008429 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385008430 RNA binding surface [nucleotide binding]; other site 448385008431 AAA domain; Region: AAA_31; pfam13614 448385008432 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 448385008433 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385008434 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 448385008435 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 448385008436 NAD(P) binding site [chemical binding]; other site 448385008437 catalytic residues [active] 448385008438 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385008439 Protein phosphatase 2C; Region: PP2C; pfam00481 448385008440 active site 448385008441 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 448385008442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385008443 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385008444 TM-ABC transporter signature motif; other site 448385008445 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385008446 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385008447 Walker A/P-loop; other site 448385008448 ATP binding site [chemical binding]; other site 448385008449 Q-loop/lid; other site 448385008450 ABC transporter signature motif; other site 448385008451 Walker B; other site 448385008452 D-loop; other site 448385008453 H-loop/switch region; other site 448385008454 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385008455 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 448385008456 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385008457 ligand binding site [chemical binding]; other site 448385008458 dimerization interface [polypeptide binding]; other site 448385008459 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385008460 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385008461 Flagellin N-methylase; Region: FliB; pfam03692 448385008462 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385008463 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 448385008464 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385008465 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385008466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008468 active site 448385008469 ATP binding site [chemical binding]; other site 448385008470 substrate binding site [chemical binding]; other site 448385008471 activation loop (A-loop); other site 448385008472 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385008473 AAA ATPase domain; Region: AAA_16; pfam13191 448385008474 Predicted ATPase [General function prediction only]; Region: COG3899 448385008475 Alpha-2-macroglobulin family; Region: A2M; pfam00207 448385008476 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385008477 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385008478 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385008479 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 448385008480 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385008481 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385008482 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385008483 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385008484 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385008485 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385008486 Lipocalin-like domain; Region: Lipocalin_6; pfam13944 448385008487 RHS Repeat; Region: RHS_repeat; pfam05593 448385008488 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385008489 RHS Repeat; Region: RHS_repeat; pfam05593 448385008490 RHS Repeat; Region: RHS_repeat; pfam05593 448385008491 RHS Repeat; Region: RHS_repeat; pfam05593 448385008492 RHS Repeat; Region: RHS_repeat; pfam05593 448385008493 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385008494 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 448385008495 substrate binding site [chemical binding]; other site 448385008496 active site 448385008497 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 448385008498 metal binding site [ion binding]; metal-binding site 448385008499 ligand binding site [chemical binding]; other site 448385008500 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 448385008501 periplasmic chaperone; Provisional; Region: PRK10780 448385008502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008504 active site 448385008505 ATP binding site [chemical binding]; other site 448385008506 substrate binding site [chemical binding]; other site 448385008507 activation loop (A-loop); other site 448385008508 AAA ATPase domain; Region: AAA_16; pfam13191 448385008509 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385008510 Protein phosphatase 2C; Region: PP2C; pfam00481 448385008511 active site 448385008512 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 448385008513 MutS domain I; Region: MutS_I; pfam01624 448385008514 MutS domain II; Region: MutS_II; pfam05188 448385008515 MutS domain III; Region: MutS_III; pfam05192 448385008516 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 448385008517 Walker A/P-loop; other site 448385008518 ATP binding site [chemical binding]; other site 448385008519 Q-loop/lid; other site 448385008520 ABC transporter signature motif; other site 448385008521 Walker B; other site 448385008522 D-loop; other site 448385008523 H-loop/switch region; other site 448385008524 IPT/TIG domain; Region: TIG; pfam01833 448385008525 IPT/TIG domain; Region: TIG; pfam01833 448385008526 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 448385008527 rRNA interaction site [nucleotide binding]; other site 448385008528 S8 interaction site; other site 448385008529 putative laminin-1 binding site; other site 448385008530 elongation factor Ts; Provisional; Region: tsf; PRK09377 448385008531 UBA/TS-N domain; Region: UBA; pfam00627 448385008532 Elongation factor TS; Region: EF_TS; pfam00889 448385008533 Elongation factor TS; Region: EF_TS; pfam00889 448385008534 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 448385008535 putative active site [active] 448385008536 putative catalytic site [active] 448385008537 putative Zn binding site [ion binding]; other site 448385008538 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 448385008539 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 448385008540 AAA domain; Region: AAA_22; pfam13401 448385008541 AAA ATPase domain; Region: AAA_16; pfam13191 448385008542 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 448385008543 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 448385008544 Walker A/P-loop; other site 448385008545 ATP binding site [chemical binding]; other site 448385008546 Q-loop/lid; other site 448385008547 ABC transporter signature motif; other site 448385008548 Walker B; other site 448385008549 D-loop; other site 448385008550 H-loop/switch region; other site 448385008551 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385008552 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 448385008553 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 448385008554 metal binding triad [ion binding]; metal-binding site 448385008555 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 448385008556 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 448385008557 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 448385008558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008559 binding surface 448385008560 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385008561 TPR motif; other site 448385008562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008563 TPR motif; other site 448385008564 binding surface 448385008565 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 448385008566 ParB-like nuclease domain; Region: ParB; smart00470 448385008567 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 448385008568 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385008569 P-loop; other site 448385008570 Magnesium ion binding site [ion binding]; other site 448385008571 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385008572 Magnesium ion binding site [ion binding]; other site 448385008573 trigger factor; Region: tig; TIGR00115 448385008574 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385008575 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 448385008576 Clp protease; Region: CLP_protease; pfam00574 448385008577 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 448385008578 oligomer interface [polypeptide binding]; other site 448385008579 active site residues [active] 448385008580 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 448385008581 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 448385008582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008583 Walker A motif; other site 448385008584 ATP binding site [chemical binding]; other site 448385008585 Walker B motif; other site 448385008586 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385008587 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 448385008588 Found in ATP-dependent protease La (LON); Region: LON; smart00464 448385008589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008590 Walker A motif; other site 448385008591 ATP binding site [chemical binding]; other site 448385008592 Walker B motif; other site 448385008593 arginine finger; other site 448385008594 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385008595 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 448385008596 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 448385008597 purine monophosphate binding site [chemical binding]; other site 448385008598 dimer interface [polypeptide binding]; other site 448385008599 putative catalytic residues [active] 448385008600 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 448385008601 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 448385008602 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 448385008603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385008604 P-loop; other site 448385008605 Magnesium ion binding site [ion binding]; other site 448385008606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385008607 Magnesium ion binding site [ion binding]; other site 448385008608 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 448385008609 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 448385008610 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 448385008611 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 448385008612 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 448385008613 molybdopterin cofactor binding site; other site 448385008614 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 448385008615 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 448385008616 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385008617 active site 448385008618 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385008619 metal ion-dependent adhesion site (MIDAS); other site 448385008620 glycogen synthase; Provisional; Region: glgA; PRK00654 448385008621 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 448385008622 ADP-binding pocket [chemical binding]; other site 448385008623 homodimer interface [polypeptide binding]; other site 448385008624 YtkA-like; Region: YtkA; pfam13115 448385008625 VPS10 domain; Region: VPS10; smart00602 448385008626 PAS domain S-box; Region: sensory_box; TIGR00229 448385008627 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 448385008628 HflX GTPase family; Region: HflX; cd01878 448385008629 G1 box; other site 448385008630 GTP/Mg2+ binding site [chemical binding]; other site 448385008631 Switch I region; other site 448385008632 G2 box; other site 448385008633 G3 box; other site 448385008634 Switch II region; other site 448385008635 G4 box; other site 448385008636 G5 box; other site 448385008637 Domain of unknown function (DUF309); Region: DUF309; pfam03745 448385008638 Response regulator receiver domain; Region: Response_reg; pfam00072 448385008639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008640 active site 448385008641 phosphorylation site [posttranslational modification] 448385008642 intermolecular recognition site; other site 448385008643 dimerization interface [polypeptide binding]; other site 448385008644 Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cl12263 448385008645 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385008646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385008647 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385008648 RNA binding site [nucleotide binding]; other site 448385008649 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 448385008650 RNA binding site [nucleotide binding]; other site 448385008651 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 448385008652 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385008653 Amidase; Region: Amidase; cl11426 448385008654 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 448385008655 AAA domain; Region: AAA_22; pfam13401 448385008656 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 448385008657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385008658 substrate binding site [chemical binding]; other site 448385008659 oxyanion hole (OAH) forming residues; other site 448385008660 trimer interface [polypeptide binding]; other site 448385008661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385008662 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 448385008663 substrate binding site [chemical binding]; other site 448385008664 oxyanion hole (OAH) forming residues; other site 448385008665 trimer interface [polypeptide binding]; other site 448385008666 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 448385008667 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 448385008668 dimer interface [polypeptide binding]; other site 448385008669 active site 448385008670 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 448385008671 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 448385008672 dimer interface [polypeptide binding]; other site 448385008673 active site 448385008674 acyl carrier protein; Validated; Region: PRK07117 448385008675 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 448385008676 FMN binding site [chemical binding]; other site 448385008677 substrate binding site [chemical binding]; other site 448385008678 putative catalytic residue [active] 448385008679 Phosphopantetheine attachment site; Region: PP-binding; cl09936 448385008680 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 448385008681 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385008682 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 448385008683 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 448385008684 active site 448385008685 dimer interface [polypeptide binding]; other site 448385008686 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 448385008687 Ligand Binding Site [chemical binding]; other site 448385008688 Molecular Tunnel; other site 448385008689 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008690 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385008691 active site 448385008692 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008693 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008694 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008695 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008696 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008697 active site 448385008698 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008699 putative NADP binding site [chemical binding]; other site 448385008700 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008701 active site 448385008702 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008703 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008704 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008705 active site 448385008706 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008707 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008708 KR domain; Region: KR; pfam08659 448385008709 putative NADP binding site [chemical binding]; other site 448385008710 active site 448385008711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008712 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385008713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008714 active site 448385008715 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008716 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008717 KR domain; Region: KR; pfam08659 448385008718 putative NADP binding site [chemical binding]; other site 448385008719 active site 448385008720 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008721 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008722 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008723 active site 448385008724 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008725 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008726 KR domain; Region: KR; pfam08659 448385008727 putative NADP binding site [chemical binding]; other site 448385008728 active site 448385008729 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008730 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008732 active site 448385008733 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008736 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008737 active site 448385008738 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008739 putative NADP binding site [chemical binding]; other site 448385008740 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008741 active site 448385008742 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385008743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008744 S-adenosylmethionine binding site [chemical binding]; other site 448385008745 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008746 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008747 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008748 active site 448385008749 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008750 putative NADP binding site [chemical binding]; other site 448385008751 KR domain; Region: KR; pfam08659 448385008752 active site 448385008753 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008755 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385008756 active site 448385008757 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008758 putative NADP binding site [chemical binding]; other site 448385008759 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008760 active site 448385008761 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008762 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008763 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008764 active site 448385008765 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008766 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008767 putative NADP binding site [chemical binding]; other site 448385008768 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008769 active site 448385008770 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008771 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008772 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385008773 active site 448385008774 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008775 putative NADP binding site [chemical binding]; other site 448385008776 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008777 active site 448385008778 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008779 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008780 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008781 active site 448385008782 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 448385008783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008784 S-adenosylmethionine binding site [chemical binding]; other site 448385008785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008786 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008787 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008788 active site 448385008789 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008790 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008791 putative NADP binding site [chemical binding]; other site 448385008792 active site 448385008793 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008794 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008795 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008796 active site 448385008797 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008798 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008800 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008801 active site 448385008802 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008803 KR domain; Region: KR; pfam08659 448385008804 putative NADP binding site [chemical binding]; other site 448385008805 active site 448385008806 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008807 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008808 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008809 active site 448385008810 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008811 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008812 putative NADP binding site [chemical binding]; other site 448385008813 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008814 active site 448385008815 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385008816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008817 S-adenosylmethionine binding site [chemical binding]; other site 448385008818 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008819 polyketide synthase; Region: polyketide_synthase; cd08251 448385008820 Enoylreductase; Region: PKS_ER; smart00829 448385008821 putative NAD(P) binding site [chemical binding]; other site 448385008822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008823 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008824 active site 448385008825 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008826 putative NADP binding site [chemical binding]; other site 448385008827 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008828 active site 448385008829 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385008830 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008831 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008832 active site 448385008833 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385008834 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008835 putative NADP binding site [chemical binding]; other site 448385008836 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385008837 active site 448385008838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008839 S-adenosylmethionine binding site [chemical binding]; other site 448385008840 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008841 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008842 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008843 active site 448385008844 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385008845 KR domain; Region: KR; pfam08659 448385008846 putative NADP binding site [chemical binding]; other site 448385008847 active site 448385008848 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008849 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385008850 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385008851 active site 448385008852 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385008853 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_13; cd13141 448385008854 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385008855 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385008856 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 448385008857 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 448385008858 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385008859 RHS Repeat; Region: RHS_repeat; pfam05593 448385008860 RHS Repeat; Region: RHS_repeat; pfam05593 448385008861 RHS Repeat; Region: RHS_repeat; cl11982 448385008862 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385008863 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 448385008864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385008865 Walker A/P-loop; other site 448385008866 ATP binding site [chemical binding]; other site 448385008867 Q-loop/lid; other site 448385008868 ABC transporter signature motif; other site 448385008869 Walker B; other site 448385008870 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 448385008871 active site 448385008872 catalytic residues [active] 448385008873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385008874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385008875 ATP binding site [chemical binding]; other site 448385008876 Mg2+ binding site [ion binding]; other site 448385008877 G-X-G motif; other site 448385008878 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385008879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385008880 active site 448385008881 phosphorylation site [posttranslational modification] 448385008882 intermolecular recognition site; other site 448385008883 dimerization interface [polypeptide binding]; other site 448385008884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008885 Walker A motif; other site 448385008886 ATP binding site [chemical binding]; other site 448385008887 Walker B motif; other site 448385008888 arginine finger; other site 448385008889 Caspase domain; Region: Peptidase_C14; pfam00656 448385008890 TIR domain; Region: TIR_2; pfam13676 448385008891 TIR domain; Region: TIR_2; pfam13676 448385008892 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385008893 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385008894 structural tetrad; other site 448385008895 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385008896 structural tetrad; other site 448385008897 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385008898 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 448385008899 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385008900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385008901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385008902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385008903 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008904 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008905 active site 448385008906 ATP binding site [chemical binding]; other site 448385008907 substrate binding site [chemical binding]; other site 448385008908 activation loop (A-loop); other site 448385008909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385008910 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385008911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008912 binding surface 448385008913 TPR motif; other site 448385008914 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385008915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008916 Walker A motif; other site 448385008917 ATP binding site [chemical binding]; other site 448385008918 Walker B motif; other site 448385008919 arginine finger; other site 448385008920 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385008921 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 448385008922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008923 active site 448385008924 ATP binding site [chemical binding]; other site 448385008925 substrate binding site [chemical binding]; other site 448385008926 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 448385008927 activation loop (A-loop); other site 448385008928 cyclase homology domain; Region: CHD; cd07302 448385008929 dimer interface [polypeptide binding]; other site 448385008930 nucleotidyl binding site; other site 448385008931 metal binding site [ion binding]; metal-binding site 448385008932 AAA ATPase domain; Region: AAA_16; pfam13191 448385008933 Walker A motif; other site 448385008934 ATP binding site [chemical binding]; other site 448385008935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385008936 S-adenosylmethionine binding site [chemical binding]; other site 448385008937 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 448385008938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385008939 DNA-binding site [nucleotide binding]; DNA binding site 448385008940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385008941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385008942 homodimer interface [polypeptide binding]; other site 448385008943 catalytic residue [active] 448385008944 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 448385008945 short chain dehydrogenase; Provisional; Region: PRK06180 448385008946 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 448385008947 NADP binding site [chemical binding]; other site 448385008948 active site 448385008949 steroid binding site; other site 448385008950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385008951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385008952 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 448385008953 putative effector binding pocket; other site 448385008954 putative dimerization interface [polypeptide binding]; other site 448385008955 M6 family metalloprotease domain; Region: M6dom_TIGR03296 448385008956 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385008957 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385008958 phosphopeptide binding site; other site 448385008959 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385008960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385008961 Walker B motif; other site 448385008962 arginine finger; other site 448385008963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385008964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385008965 active site 448385008966 ATP binding site [chemical binding]; other site 448385008967 substrate binding site [chemical binding]; other site 448385008968 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385008969 substrate binding site [chemical binding]; other site 448385008970 activation loop (A-loop); other site 448385008971 activation loop (A-loop); other site 448385008972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385008973 TPR repeat; Region: TPR_11; pfam13414 448385008974 TPR motif; other site 448385008975 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 448385008976 PLD-like domain; Region: PLDc_2; pfam13091 448385008977 putative homodimer interface [polypeptide binding]; other site 448385008978 putative active site [active] 448385008979 catalytic site [active] 448385008980 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 448385008981 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 448385008982 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 448385008983 nucleotide binding region [chemical binding]; other site 448385008984 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 448385008985 Predicted ATPase [General function prediction only]; Region: COG4637 448385008986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385008987 Walker A/P-loop; other site 448385008988 ATP binding site [chemical binding]; other site 448385008989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385008990 ATP binding site [chemical binding]; other site 448385008991 Q-loop/lid; other site 448385008992 ABC transporter signature motif; other site 448385008993 Walker B; other site 448385008994 D-loop; other site 448385008995 H-loop/switch region; other site 448385008996 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 448385008997 PLD-like domain; Region: PLDc_2; pfam13091 448385008998 putative active site [active] 448385008999 putative catalytic site [active] 448385009000 helicase superfamily c-terminal domain; Region: HELICc; smart00490 448385009001 ATP-binding site [chemical binding]; other site 448385009002 TIGR02646 family protein; Region: TIGR02646 448385009003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385009004 AAA domain; Region: AAA_23; pfam13476 448385009005 Walker A/P-loop; other site 448385009006 ATP binding site [chemical binding]; other site 448385009007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385009008 Q-loop/lid; other site 448385009009 ABC transporter signature motif; other site 448385009010 Walker B; other site 448385009011 D-loop; other site 448385009012 H-loop/switch region; other site 448385009013 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 448385009014 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385009015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385009016 ATP binding site [chemical binding]; other site 448385009017 putative Mg++ binding site [ion binding]; other site 448385009018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385009019 nucleotide binding region [chemical binding]; other site 448385009020 ATP-binding site [chemical binding]; other site 448385009021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009023 binding surface 448385009024 TPR motif; other site 448385009025 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 448385009026 AAA ATPase domain; Region: AAA_16; pfam13191 448385009027 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 448385009028 Protein of unknown function (DUF524); Region: DUF524; pfam04411 448385009029 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 448385009030 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385009031 putative NAD(P) binding site [chemical binding]; other site 448385009032 transcriptional regulator; Provisional; Region: PRK10632 448385009033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385009034 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385009035 putative effector binding pocket; other site 448385009036 dimerization interface [polypeptide binding]; other site 448385009037 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 448385009038 classical (c) SDRs; Region: SDR_c; cd05233 448385009039 NAD(P) binding site [chemical binding]; other site 448385009040 active site 448385009041 MbtH-like protein; Region: MbtH; cl01279 448385009042 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385009043 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 448385009044 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385009045 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385009046 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385009047 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 448385009048 TrkA-N domain; Region: TrkA_N; pfam02254 448385009049 TrkA-C domain; Region: TrkA_C; pfam02080 448385009050 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 448385009051 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 448385009052 CotH protein; Region: CotH; pfam08757 448385009053 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 448385009054 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385009055 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385009056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009057 active site 448385009058 phosphorylation site [posttranslational modification] 448385009059 intermolecular recognition site; other site 448385009060 dimerization interface [polypeptide binding]; other site 448385009061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385009062 Walker A motif; other site 448385009063 ATP binding site [chemical binding]; other site 448385009064 Walker B motif; other site 448385009065 arginine finger; other site 448385009066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385009067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009068 dimer interface [polypeptide binding]; other site 448385009069 phosphorylation site [posttranslational modification] 448385009070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009071 ATP binding site [chemical binding]; other site 448385009072 Mg2+ binding site [ion binding]; other site 448385009073 G-X-G motif; other site 448385009074 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 448385009075 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 448385009076 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 448385009077 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 448385009078 active site 448385009079 homotetramer interface [polypeptide binding]; other site 448385009080 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 448385009081 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 448385009082 Phosphotransferase enzyme family; Region: APH; pfam01636 448385009083 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385009084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 448385009085 catalytic core [active] 448385009086 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 448385009087 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385009088 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 448385009089 short chain dehydrogenase; Provisional; Region: PRK12937 448385009090 NADP binding site [chemical binding]; other site 448385009091 homodimer interface [polypeptide binding]; other site 448385009092 active site 448385009093 substrate binding site [chemical binding]; other site 448385009094 Glycine-rich protein domain (DUF2403); Region: DUF2403; pfam10290 448385009095 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 448385009096 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385009097 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 448385009098 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 448385009099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385009100 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385009101 active site 448385009102 metal binding site [ion binding]; metal-binding site 448385009103 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 448385009104 GAF domain; Region: GAF; pfam01590 448385009105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385009106 Walker A motif; other site 448385009107 ATP binding site [chemical binding]; other site 448385009108 Walker B motif; other site 448385009109 arginine finger; other site 448385009110 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385009111 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 448385009112 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 448385009113 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 448385009114 PA14 domain; Region: PA14; cl08459 448385009115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385009116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009117 dimer interface [polypeptide binding]; other site 448385009118 phosphorylation site [posttranslational modification] 448385009119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009120 ATP binding site [chemical binding]; other site 448385009121 G-X-G motif; other site 448385009122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385009123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009124 active site 448385009125 phosphorylation site [posttranslational modification] 448385009126 intermolecular recognition site; other site 448385009127 dimerization interface [polypeptide binding]; other site 448385009128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385009129 DNA binding site [nucleotide binding] 448385009130 Hemerythrin-like domain; Region: Hr-like; cd12108 448385009131 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385009132 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385009133 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 448385009134 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 448385009135 carboxyltransferase (CT) interaction site; other site 448385009136 biotinylation site [posttranslational modification]; other site 448385009137 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 448385009138 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 448385009139 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 448385009140 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 448385009141 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 448385009142 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 448385009143 FOG: CBS domain [General function prediction only]; Region: COG0517 448385009144 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385009145 FOG: CBS domain [General function prediction only]; Region: COG0517 448385009146 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385009147 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385009148 Ligand Binding Site [chemical binding]; other site 448385009149 Domain of unknown function (DUF303); Region: DUF303; pfam03629 448385009150 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 448385009151 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 448385009152 [2Fe-2S] cluster binding site [ion binding]; other site 448385009153 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 448385009154 putative alpha subunit interface [polypeptide binding]; other site 448385009155 putative active site [active] 448385009156 putative substrate binding site [chemical binding]; other site 448385009157 Fe binding site [ion binding]; other site 448385009158 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 448385009159 active site 448385009160 catalytic triad [active] 448385009161 oxyanion hole [active] 448385009162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 448385009163 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 448385009164 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 448385009165 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385009166 active site 448385009167 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 448385009168 ligand binding site [chemical binding]; other site 448385009169 metal binding site [ion binding]; metal-binding site 448385009170 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385009171 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385009172 TM-ABC transporter signature motif; other site 448385009173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385009174 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385009175 TM-ABC transporter signature motif; other site 448385009176 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385009177 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385009178 Walker A/P-loop; other site 448385009179 ATP binding site [chemical binding]; other site 448385009180 Q-loop/lid; other site 448385009181 ABC transporter signature motif; other site 448385009182 Walker B; other site 448385009183 D-loop; other site 448385009184 H-loop/switch region; other site 448385009185 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385009186 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 448385009187 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385009188 putative ligand binding site [chemical binding]; other site 448385009189 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 448385009190 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 448385009191 intersubunit interface [polypeptide binding]; other site 448385009192 active site 448385009193 Zn2+ binding site [ion binding]; other site 448385009194 L-arabinose isomerase; Provisional; Region: PRK02929 448385009195 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 448385009196 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 448385009197 trimer interface [polypeptide binding]; other site 448385009198 putative substrate binding site [chemical binding]; other site 448385009199 putative metal binding site [ion binding]; other site 448385009200 ribulokinase; Provisional; Region: PRK04123 448385009201 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 448385009202 N- and C-terminal domain interface [polypeptide binding]; other site 448385009203 active site 448385009204 MgATP binding site [chemical binding]; other site 448385009205 catalytic site [active] 448385009206 metal binding site [ion binding]; metal-binding site 448385009207 carbohydrate binding site [chemical binding]; other site 448385009208 homodimer interface [polypeptide binding]; other site 448385009209 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 448385009210 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385009211 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385009212 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385009213 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385009214 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385009215 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385009216 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 448385009217 DNA binding site [nucleotide binding] 448385009218 domain linker motif; other site 448385009219 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 448385009220 ligand binding site [chemical binding]; other site 448385009221 dimerization interface (open form) [polypeptide binding]; other site 448385009222 dimerization interface (closed form) [polypeptide binding]; other site 448385009223 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 448385009224 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385009225 metal ion-dependent adhesion site (MIDAS); other site 448385009226 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 448385009227 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385009228 active site 448385009229 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 448385009230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385009231 putative ligand binding site [chemical binding]; other site 448385009232 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385009233 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385009234 Walker A/P-loop; other site 448385009235 ATP binding site [chemical binding]; other site 448385009236 Q-loop/lid; other site 448385009237 ABC transporter signature motif; other site 448385009238 Walker B; other site 448385009239 D-loop; other site 448385009240 H-loop/switch region; other site 448385009241 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385009242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385009243 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385009244 TM-ABC transporter signature motif; other site 448385009245 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 448385009246 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 448385009247 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 448385009248 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385009249 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385009250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385009251 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385009252 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385009253 active site 448385009254 catalytic tetrad [active] 448385009255 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 448385009256 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 448385009257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 448385009258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385009259 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385009260 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 448385009261 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 448385009262 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 448385009263 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 448385009264 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 448385009265 XdhC Rossmann domain; Region: XdhC_C; pfam13478 448385009266 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 448385009267 metal-binding site 448385009268 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 448385009269 SnoaL-like domain; Region: SnoaL_3; pfam13474 448385009270 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 448385009271 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385009272 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009273 active site 448385009274 ATP binding site [chemical binding]; other site 448385009275 substrate binding site [chemical binding]; other site 448385009276 activation loop (A-loop); other site 448385009277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385009278 Walker A motif; other site 448385009279 ATP binding site [chemical binding]; other site 448385009280 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385009281 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385009282 active site 448385009283 active site 448385009284 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 448385009285 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385009286 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 448385009287 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 448385009288 dimer interface [polypeptide binding]; other site 448385009289 active site 448385009290 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385009291 active site 448385009292 Phosphopantetheine attachment site; Region: PP-binding; cl09936 448385009293 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 448385009294 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 448385009295 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 448385009296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385009297 NAD(P) binding site [chemical binding]; other site 448385009298 active site 448385009299 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 448385009300 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385009301 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 448385009302 active site 2 [active] 448385009303 dimer interface [polypeptide binding]; other site 448385009304 active site 1 [active] 448385009305 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 448385009306 septum formation inhibitor; Reviewed; Region: minC; PRK00339 448385009307 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 448385009308 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 448385009309 substrate binding site [chemical binding]; other site 448385009310 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 448385009311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 448385009312 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 448385009313 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 448385009314 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385009315 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385009316 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 448385009317 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 448385009318 Switch I; other site 448385009319 Switch II; other site 448385009320 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 448385009321 Uncharacterized conserved protein [Function unknown]; Region: COG4279 448385009322 SNF2 Helicase protein; Region: DUF3670; pfam12419 448385009323 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 448385009324 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385009325 ATP binding site [chemical binding]; other site 448385009326 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 448385009327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385009328 nucleotide binding region [chemical binding]; other site 448385009329 ATP-binding site [chemical binding]; other site 448385009330 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385009331 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 448385009332 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 448385009333 active site 448385009334 homotetramer interface [polypeptide binding]; other site 448385009335 homodimer interface [polypeptide binding]; other site 448385009336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385009337 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 448385009338 dimerization interface [polypeptide binding]; other site 448385009339 D-mannose binding lectin; Region: B_lectin; pfam01453 448385009340 mannose binding site [chemical binding]; other site 448385009341 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 448385009342 nucleoside/Zn binding site; other site 448385009343 dimer interface [polypeptide binding]; other site 448385009344 catalytic motif [active] 448385009345 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385009346 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 448385009347 substrate binding pocket [chemical binding]; other site 448385009348 membrane-bound complex binding site; other site 448385009349 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385009350 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385009351 Walker A/P-loop; other site 448385009352 ATP binding site [chemical binding]; other site 448385009353 Q-loop/lid; other site 448385009354 ABC transporter signature motif; other site 448385009355 Walker B; other site 448385009356 D-loop; other site 448385009357 H-loop/switch region; other site 448385009358 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385009359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385009360 dimer interface [polypeptide binding]; other site 448385009361 conserved gate region; other site 448385009362 putative PBP binding loops; other site 448385009363 ABC-ATPase subunit interface; other site 448385009364 Isochorismatase family; Region: Isochorismatase; pfam00857 448385009365 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 448385009366 catalytic triad [active] 448385009367 conserved cis-peptide bond; other site 448385009368 PAS fold; Region: PAS_4; pfam08448 448385009369 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385009370 putative active site [active] 448385009371 heme pocket [chemical binding]; other site 448385009372 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385009373 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 448385009374 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385009375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385009376 Pirin; Region: Pirin; pfam02678 448385009377 Pirin-related protein [General function prediction only]; Region: COG1741 448385009378 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 448385009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385009380 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385009381 putative substrate translocation pore; other site 448385009382 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009383 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009384 active site 448385009385 ATP binding site [chemical binding]; other site 448385009386 substrate binding site [chemical binding]; other site 448385009387 activation loop (A-loop); other site 448385009388 TPR repeat; Region: TPR_11; pfam13414 448385009389 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 448385009390 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 448385009391 putative tRNA-binding site [nucleotide binding]; other site 448385009392 B3/4 domain; Region: B3_4; pfam03483 448385009393 tRNA synthetase B5 domain; Region: B5; smart00874 448385009394 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 448385009395 dimer interface [polypeptide binding]; other site 448385009396 motif 1; other site 448385009397 motif 3; other site 448385009398 motif 2; other site 448385009399 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 448385009400 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 448385009401 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 448385009402 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 448385009403 dimer interface [polypeptide binding]; other site 448385009404 motif 1; other site 448385009405 active site 448385009406 motif 2; other site 448385009407 motif 3; other site 448385009408 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385009409 metal ion-dependent adhesion site (MIDAS); other site 448385009410 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009412 active site 448385009413 ATP binding site [chemical binding]; other site 448385009414 substrate binding site [chemical binding]; other site 448385009415 activation loop (A-loop); other site 448385009416 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 448385009417 Helix-turn-helix domain; Region: HTH_28; pfam13518 448385009418 Winged helix-turn helix; Region: HTH_29; pfam13551 448385009419 Homeodomain-like domain; Region: HTH_32; pfam13565 448385009420 Integrase core domain; Region: rve; pfam00665 448385009421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385009422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385009423 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385009424 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 448385009425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385009426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385009427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 448385009428 Integrase core domain; Region: rve; pfam00665 448385009429 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009430 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009431 TPR motif; other site 448385009432 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385009433 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385009434 active site 448385009435 catalytic tetrad [active] 448385009436 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 448385009437 Leucine-rich repeats; other site 448385009438 Substrate binding site [chemical binding]; other site 448385009439 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385009440 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385009441 phosphopeptide binding site; other site 448385009442 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385009443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385009444 Walker A motif; other site 448385009445 ATP binding site [chemical binding]; other site 448385009446 Walker B motif; other site 448385009447 arginine finger; other site 448385009448 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385009449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385009450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385009451 metal binding site [ion binding]; metal-binding site 448385009452 active site 448385009453 I-site; other site 448385009454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 448385009455 Pectate lyase; Region: Pectate_lyase; pfam03211 448385009456 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 448385009457 active site 448385009458 putative interdomain interaction site [polypeptide binding]; other site 448385009459 putative metal-binding site [ion binding]; other site 448385009460 putative nucleotide binding site [chemical binding]; other site 448385009461 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 448385009462 domain I; other site 448385009463 phosphate binding site [ion binding]; other site 448385009464 Bacterial DNA topoisomerase I DNA-binding domain; Region: TOP1Ac; smart00437 448385009465 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 448385009466 domain IV; other site 448385009467 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385009468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385009469 ATP binding site [chemical binding]; other site 448385009470 putative Mg++ binding site [ion binding]; other site 448385009471 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385009472 nucleotide binding region [chemical binding]; other site 448385009473 ATP-binding site [chemical binding]; other site 448385009474 Beta-propeller repeat; Region: SBBP; pfam06739 448385009475 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 448385009476 classical (c) SDRs; Region: SDR_c; cd05233 448385009477 NAD(P) binding site [chemical binding]; other site 448385009478 active site 448385009479 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385009480 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385009481 ligand binding site [chemical binding]; other site 448385009482 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 448385009483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385009484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009485 dimer interface [polypeptide binding]; other site 448385009486 phosphorylation site [posttranslational modification] 448385009487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009488 ATP binding site [chemical binding]; other site 448385009489 Mg2+ binding site [ion binding]; other site 448385009490 G-X-G motif; other site 448385009491 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 448385009492 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 448385009493 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 448385009494 active site 448385009495 ADP/pyrophosphate binding site [chemical binding]; other site 448385009496 allosteric effector site; other site 448385009497 dimerization interface [polypeptide binding]; other site 448385009498 fructose-1,6-bisphosphate binding site; other site 448385009499 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 448385009500 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 448385009501 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009502 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009503 active site 448385009504 ATP binding site [chemical binding]; other site 448385009505 substrate binding site [chemical binding]; other site 448385009506 activation loop (A-loop); other site 448385009507 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 448385009508 trimer interface [polypeptide binding]; other site 448385009509 active site 448385009510 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 448385009511 Peptidase family M50; Region: Peptidase_M50; pfam02163 448385009512 active site 448385009513 putative substrate binding region [chemical binding]; other site 448385009514 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 448385009515 active site 448385009516 catalytic triad [active] 448385009517 oxyanion hole [active] 448385009518 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385009519 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385009520 putative acyl-acceptor binding pocket; other site 448385009521 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 448385009522 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 448385009523 hypothetical protein; Provisional; Region: PRK05409 448385009524 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 448385009525 putative hydrophobic ligand binding site [chemical binding]; other site 448385009526 protein interface [polypeptide binding]; other site 448385009527 gate; other site 448385009528 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 448385009529 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 448385009530 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385009531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385009532 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385009533 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385009534 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385009535 ligand binding site [chemical binding]; other site 448385009536 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 448385009537 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 448385009538 peptide binding site [polypeptide binding]; other site 448385009539 UDP-glucose 4-epimerase; Region: PLN02240 448385009540 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 448385009541 NAD binding site [chemical binding]; other site 448385009542 homodimer interface [polypeptide binding]; other site 448385009543 active site 448385009544 substrate binding site [chemical binding]; other site 448385009545 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 448385009546 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 448385009547 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 448385009548 peptide binding site [polypeptide binding]; other site 448385009549 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 448385009550 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 448385009551 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 448385009552 trimer interface [polypeptide binding]; other site 448385009553 active site 448385009554 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 448385009555 catalytic site [active] 448385009556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385009557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385009558 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385009559 putative effector binding pocket; other site 448385009560 dimerization interface [polypeptide binding]; other site 448385009561 short chain dehydrogenase; Provisional; Region: PRK07041 448385009562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385009563 NAD(P) binding site [chemical binding]; other site 448385009564 active site 448385009565 PA14 domain; Region: PA14; cl08459 448385009566 Methyltransferase domain; Region: Methyltransf_11; pfam08241 448385009567 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 448385009568 beta-galactosidase; Region: BGL; TIGR03356 448385009569 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 448385009570 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 448385009571 NADP binding site [chemical binding]; other site 448385009572 dimer interface [polypeptide binding]; other site 448385009573 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 448385009574 GSH binding site [chemical binding]; other site 448385009575 catalytic residues [active] 448385009576 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 448385009577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385009578 dimer interface [polypeptide binding]; other site 448385009579 conserved gate region; other site 448385009580 putative PBP binding loops; other site 448385009581 ABC-ATPase subunit interface; other site 448385009582 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 448385009583 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 448385009584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385009585 dimer interface [polypeptide binding]; other site 448385009586 conserved gate region; other site 448385009587 putative PBP binding loops; other site 448385009588 ABC-ATPase subunit interface; other site 448385009589 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 448385009590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385009591 Walker A/P-loop; other site 448385009592 ATP binding site [chemical binding]; other site 448385009593 Q-loop/lid; other site 448385009594 ABC transporter signature motif; other site 448385009595 Walker B; other site 448385009596 D-loop; other site 448385009597 H-loop/switch region; other site 448385009598 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 448385009599 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 448385009600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385009601 Walker A/P-loop; other site 448385009602 ATP binding site [chemical binding]; other site 448385009603 Q-loop/lid; other site 448385009604 ABC transporter signature motif; other site 448385009605 Walker B; other site 448385009606 D-loop; other site 448385009607 H-loop/switch region; other site 448385009608 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 448385009609 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 448385009610 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385009611 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385009612 active site 448385009613 metal binding site [ion binding]; metal-binding site 448385009614 FOG: CBS domain [General function prediction only]; Region: COG0517 448385009615 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385009616 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009618 active site 448385009619 ATP binding site [chemical binding]; other site 448385009620 substrate binding site [chemical binding]; other site 448385009621 activation loop (A-loop); other site 448385009622 AAA ATPase domain; Region: AAA_16; pfam13191 448385009623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009625 binding surface 448385009626 TPR motif; other site 448385009627 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 448385009628 PGAP1-like protein; Region: PGAP1; pfam07819 448385009629 lipase chaperone; Provisional; Region: PRK01294 448385009630 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 448385009631 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385009632 CoenzymeA binding site [chemical binding]; other site 448385009633 subunit interaction site [polypeptide binding]; other site 448385009634 PHB binding site; other site 448385009635 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385009636 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 448385009637 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 448385009638 Family description; Region: VCBS; pfam13517 448385009639 Family description; Region: VCBS; pfam13517 448385009640 Family description; Region: VCBS; pfam13517 448385009641 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 448385009642 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385009643 putative di-iron ligands [ion binding]; other site 448385009644 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385009645 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385009646 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385009647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385009648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385009649 DNA binding residues [nucleotide binding] 448385009650 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 448385009651 dimerization interface [polypeptide binding]; other site 448385009652 D-mannose binding lectin; Region: B_lectin; pfam01453 448385009653 mannose binding site [chemical binding]; other site 448385009654 Predicted integral membrane protein [Function unknown]; Region: COG0392 448385009655 Uncharacterized conserved protein [Function unknown]; Region: COG2898 448385009656 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 448385009657 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385009658 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385009659 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 448385009660 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385009661 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385009662 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 448385009663 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 448385009664 iron-sulfur cluster [ion binding]; other site 448385009665 [2Fe-2S] cluster binding site [ion binding]; other site 448385009666 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009667 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009668 active site 448385009669 ATP binding site [chemical binding]; other site 448385009670 substrate binding site [chemical binding]; other site 448385009671 activation loop (A-loop); other site 448385009672 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385009673 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 448385009674 putative di-iron ligands [ion binding]; other site 448385009675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385009676 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385009677 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009678 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009679 active site 448385009680 ATP binding site [chemical binding]; other site 448385009681 substrate binding site [chemical binding]; other site 448385009682 activation loop (A-loop); other site 448385009683 Predicted ATPase [General function prediction only]; Region: COG3899 448385009684 AAA ATPase domain; Region: AAA_16; pfam13191 448385009685 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385009686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385009687 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385009688 DNA binding residues [nucleotide binding] 448385009689 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385009690 Protein kinase domain; Region: Pkinase; pfam00069 448385009691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009692 active site 448385009693 ATP binding site [chemical binding]; other site 448385009694 substrate binding site [chemical binding]; other site 448385009695 activation loop (A-loop); other site 448385009696 AAA ATPase domain; Region: AAA_16; pfam13191 448385009697 Predicted ATPase [General function prediction only]; Region: COG3899 448385009698 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385009699 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385009700 PAS fold; Region: PAS_4; pfam08448 448385009701 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385009702 putative active site [active] 448385009703 heme pocket [chemical binding]; other site 448385009704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385009705 GAF domain; Region: GAF; cl17456 448385009706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009707 dimer interface [polypeptide binding]; other site 448385009708 phosphorylation site [posttranslational modification] 448385009709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009710 ATP binding site [chemical binding]; other site 448385009711 Mg2+ binding site [ion binding]; other site 448385009712 G-X-G motif; other site 448385009713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385009714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385009715 putative active site [active] 448385009716 heme pocket [chemical binding]; other site 448385009717 PAS fold; Region: PAS_4; pfam08448 448385009718 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 448385009719 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385009720 PAS domain; Region: PAS_9; pfam13426 448385009721 PAS fold; Region: PAS_4; pfam08448 448385009722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 448385009723 putative active site [active] 448385009724 heme pocket [chemical binding]; other site 448385009725 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385009726 PAS domain; Region: PAS; smart00091 448385009727 PAS domain; Region: PAS_9; pfam13426 448385009728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385009729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009730 phosphorylation site [posttranslational modification] 448385009731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009732 ATP binding site [chemical binding]; other site 448385009733 Mg2+ binding site [ion binding]; other site 448385009734 G-X-G motif; other site 448385009735 Response regulator receiver domain; Region: Response_reg; pfam00072 448385009736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009737 active site 448385009738 phosphorylation site [posttranslational modification] 448385009739 intermolecular recognition site; other site 448385009740 dimerization interface [polypeptide binding]; other site 448385009741 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385009742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385009743 putative active site [active] 448385009744 heme pocket [chemical binding]; other site 448385009745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009746 dimer interface [polypeptide binding]; other site 448385009747 phosphorylation site [posttranslational modification] 448385009748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009749 ATP binding site [chemical binding]; other site 448385009750 Mg2+ binding site [ion binding]; other site 448385009751 G-X-G motif; other site 448385009752 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385009753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009754 active site 448385009755 phosphorylation site [posttranslational modification] 448385009756 intermolecular recognition site; other site 448385009757 dimerization interface [polypeptide binding]; other site 448385009758 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 448385009759 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 448385009760 Double zinc ribbon; Region: DZR; pfam12773 448385009761 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385009762 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 448385009763 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385009764 Family description; Region: VCBS; pfam13517 448385009765 Family description; Region: VCBS; pfam13517 448385009766 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385009767 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385009768 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 448385009769 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 448385009770 active site 448385009771 Zn binding site [ion binding]; other site 448385009772 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 448385009773 RES domain; Region: RES; pfam08808 448385009774 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 448385009775 active site 448385009776 DNA binding site [nucleotide binding] 448385009777 DNA ligase D; Region: NHEJ_ligase_prk; TIGR02776 448385009778 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 448385009779 DNA binding site [nucleotide binding] 448385009780 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 448385009781 nucleotide binding site [chemical binding]; other site 448385009782 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385009783 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385009784 dimer interface [polypeptide binding]; other site 448385009785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385009786 catalytic residue [active] 448385009787 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 448385009788 trimer interface [polypeptide binding]; other site 448385009789 active site 448385009790 substrate binding site [chemical binding]; other site 448385009791 Rdx family; Region: Rdx; cl01407 448385009792 MgtE intracellular N domain; Region: MgtE_N; smart00924 448385009793 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385009794 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385009795 Sel1-like repeats; Region: SEL1; smart00671 448385009796 Sel1-like repeats; Region: SEL1; smart00671 448385009797 Sel1-like repeats; Region: SEL1; smart00671 448385009798 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 448385009799 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 448385009800 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 448385009801 Family description; Region: UvrD_C_2; pfam13538 448385009802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 448385009803 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385009804 ATP binding site [chemical binding]; other site 448385009805 Mg++ binding site [ion binding]; other site 448385009806 motif III; other site 448385009807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385009808 nucleotide binding region [chemical binding]; other site 448385009809 ATP-binding site [chemical binding]; other site 448385009810 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 448385009811 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385009812 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 448385009813 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 448385009814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009816 active site 448385009817 ATP binding site [chemical binding]; other site 448385009818 substrate binding site [chemical binding]; other site 448385009819 activation loop (A-loop); other site 448385009820 2TM domain; Region: 2TM; pfam13239 448385009821 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385009822 CoenzymeA binding site [chemical binding]; other site 448385009823 subunit interaction site [polypeptide binding]; other site 448385009824 PHB binding site; other site 448385009825 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385009826 putative active site [active] 448385009827 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 448385009828 active site 448385009829 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385009830 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 448385009831 active site 448385009832 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 448385009833 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385009834 RHS Repeat; Region: RHS_repeat; pfam05593 448385009835 RHS Repeat; Region: RHS_repeat; cl11982 448385009836 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 448385009837 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 448385009838 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385009839 TIR domain; Region: TIR_2; pfam13676 448385009840 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009841 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009843 binding surface 448385009844 TPR motif; other site 448385009845 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009848 TPR motif; other site 448385009849 binding surface 448385009850 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385009851 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385009852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385009853 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385009854 TM-ABC transporter signature motif; other site 448385009855 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385009856 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385009857 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385009858 TM-ABC transporter signature motif; other site 448385009859 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 448385009860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385009861 Walker A/P-loop; other site 448385009862 ATP binding site [chemical binding]; other site 448385009863 Q-loop/lid; other site 448385009864 ABC transporter signature motif; other site 448385009865 Walker B; other site 448385009866 D-loop; other site 448385009867 H-loop/switch region; other site 448385009868 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385009869 Walker A/P-loop; other site 448385009870 ATP binding site [chemical binding]; other site 448385009871 Q-loop/lid; other site 448385009872 ABC transporter signature motif; other site 448385009873 Walker B; other site 448385009874 D-loop; other site 448385009875 H-loop/switch region; other site 448385009876 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385009877 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385009878 metal ion-dependent adhesion site (MIDAS); other site 448385009879 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 448385009880 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 448385009881 transmembrane helices; other site 448385009882 Glycerate kinase family; Region: Gly_kinase; cl00841 448385009883 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 448385009884 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 448385009885 putative active site [active] 448385009886 putative metal binding site [ion binding]; other site 448385009887 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385009888 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385009889 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009890 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385009891 active site 448385009892 ATP binding site [chemical binding]; other site 448385009893 substrate binding site [chemical binding]; other site 448385009894 activation loop (A-loop); other site 448385009895 TPR repeat; Region: TPR_11; pfam13414 448385009896 PEGA domain; Region: PEGA; pfam08308 448385009897 PEGA domain; Region: PEGA; pfam08308 448385009898 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385009899 Kelch domain; Region: Kelch; smart00612 448385009900 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385009901 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385009902 ligand binding site [chemical binding]; other site 448385009903 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385009904 active site 448385009905 metal binding site [ion binding]; metal-binding site 448385009906 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385009907 active site 448385009908 Imelysin; Region: Peptidase_M75; cl09159 448385009909 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 448385009910 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 448385009911 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 448385009912 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 448385009913 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385009914 active site 448385009915 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 448385009916 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 448385009917 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 448385009918 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 448385009919 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385009920 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 448385009921 dimer interface [polypeptide binding]; other site 448385009922 active site 448385009923 metal binding site [ion binding]; metal-binding site 448385009924 glutathione binding site [chemical binding]; other site 448385009925 YCII-related domain; Region: YCII; cl00999 448385009926 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 448385009927 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385009928 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 448385009929 Bacterial sugar transferase; Region: Bac_transf; pfam02397 448385009930 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385009931 carboxylate-amine ligase; Provisional; Region: PRK13515 448385009932 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 448385009933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385009934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385009935 active site 448385009936 ATP binding site [chemical binding]; other site 448385009937 substrate binding site [chemical binding]; other site 448385009938 activation loop (A-loop); other site 448385009939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385009940 Coenzyme A binding pocket [chemical binding]; other site 448385009941 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385009942 active site 448385009943 PQQ-like domain; Region: PQQ_2; pfam13360 448385009944 Trp docking motif [polypeptide binding]; other site 448385009945 PQQ-like domain; Region: PQQ_2; pfam13360 448385009946 Sulfatase; Region: Sulfatase; pfam00884 448385009947 Sulfatase; Region: Sulfatase; cl17466 448385009948 HEAT repeats; Region: HEAT_2; pfam13646 448385009949 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 448385009950 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 448385009951 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 448385009952 Outer membrane lipoprotein; Region: YfiO; pfam13525 448385009953 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385009954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009955 active site 448385009956 phosphorylation site [posttranslational modification] 448385009957 intermolecular recognition site; other site 448385009958 dimerization interface [polypeptide binding]; other site 448385009959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385009960 Walker A motif; other site 448385009961 ATP binding site [chemical binding]; other site 448385009962 Walker B motif; other site 448385009963 arginine finger; other site 448385009964 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385009965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385009966 dimer interface [polypeptide binding]; other site 448385009967 phosphorylation site [posttranslational modification] 448385009968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009969 ATP binding site [chemical binding]; other site 448385009970 Mg2+ binding site [ion binding]; other site 448385009971 G-X-G motif; other site 448385009972 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385009973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385009974 active site 448385009975 phosphorylation site [posttranslational modification] 448385009976 intermolecular recognition site; other site 448385009977 dimerization interface [polypeptide binding]; other site 448385009978 Class I aldolases; Region: Aldolase_Class_I; cl17187 448385009979 catalytic residue [active] 448385009980 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385009981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385009982 S-adenosylmethionine binding site [chemical binding]; other site 448385009983 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 448385009984 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 448385009985 Ligand binding site; other site 448385009986 Putative Catalytic site; other site 448385009987 DXD motif; other site 448385009988 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385009989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 448385009990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385009991 binding surface 448385009992 TPR motif; other site 448385009993 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 448385009994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385009995 ATP binding site [chemical binding]; other site 448385009996 Mg2+ binding site [ion binding]; other site 448385009997 G-X-G motif; other site 448385009998 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385009999 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 448385010000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385010001 ATP binding site [chemical binding]; other site 448385010002 Mg2+ binding site [ion binding]; other site 448385010003 G-X-G motif; other site 448385010004 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385010005 PAS domain S-box; Region: sensory_box; TIGR00229 448385010006 PAS domain; Region: PAS; smart00091 448385010007 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385010008 helicase 45; Provisional; Region: PTZ00424 448385010009 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 448385010010 ATP binding site [chemical binding]; other site 448385010011 Mg++ binding site [ion binding]; other site 448385010012 motif III; other site 448385010013 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385010014 nucleotide binding region [chemical binding]; other site 448385010015 ATP-binding site [chemical binding]; other site 448385010016 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 448385010017 RNA binding site [nucleotide binding]; other site 448385010018 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 448385010019 aldehyde dehydrogenase; Provisional; Region: PRK11903 448385010020 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 448385010021 substrate binding site [chemical binding]; other site 448385010022 dimer interface [polypeptide binding]; other site 448385010023 NADP binding site [chemical binding]; other site 448385010024 catalytic residues [active] 448385010025 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010026 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010027 active site 448385010028 ATP binding site [chemical binding]; other site 448385010029 substrate binding site [chemical binding]; other site 448385010030 activation loop (A-loop); other site 448385010031 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 448385010032 Dynamin family; Region: Dynamin_N; pfam00350 448385010033 G1 box; other site 448385010034 GTP/Mg2+ binding site [chemical binding]; other site 448385010035 G2 box; other site 448385010036 Switch I region; other site 448385010037 G3 box; other site 448385010038 Switch II region; other site 448385010039 G4 box; other site 448385010040 G5 box; other site 448385010041 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 448385010042 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 448385010043 NACHT domain; Region: NACHT; pfam05729 448385010044 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385010045 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385010046 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385010047 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385010048 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385010049 structural tetrad; other site 448385010050 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385010051 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385010052 structural tetrad; other site 448385010053 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 448385010054 Resolvase, N terminal domain; Region: Resolvase; smart00857 448385010055 catalytic nucleophile [active] 448385010056 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385010057 Predicted membrane protein [Function unknown]; Region: COG4270 448385010058 AAA ATPase domain; Region: AAA_16; pfam13191 448385010059 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385010060 structural tetrad; other site 448385010061 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385010062 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385010063 structural tetrad; other site 448385010064 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385010065 structural tetrad; other site 448385010066 TIR domain; Region: TIR_2; pfam13676 448385010067 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 448385010068 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010069 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010070 active site 448385010071 ATP binding site [chemical binding]; other site 448385010072 substrate binding site [chemical binding]; other site 448385010073 activation loop (A-loop); other site 448385010074 AAA ATPase domain; Region: AAA_16; pfam13191 448385010075 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385010076 putative active site [active] 448385010077 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 448385010078 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 448385010079 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385010080 Trp docking motif [polypeptide binding]; other site 448385010081 active site 448385010082 PQQ-like domain; Region: PQQ_2; pfam13360 448385010083 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 448385010084 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 448385010085 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385010086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385010087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385010088 DNA binding residues [nucleotide binding] 448385010089 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385010090 DNA binding residues [nucleotide binding] 448385010091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385010092 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 448385010093 catalytic site [active] 448385010094 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 448385010095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385010096 dimer interface [polypeptide binding]; other site 448385010097 conserved gate region; other site 448385010098 putative PBP binding loops; other site 448385010099 ABC-ATPase subunit interface; other site 448385010100 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 448385010101 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 448385010102 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 448385010103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385010104 ABC-ATPase subunit interface; other site 448385010105 Response regulator receiver domain; Region: Response_reg; pfam00072 448385010106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385010107 active site 448385010108 phosphorylation site [posttranslational modification] 448385010109 intermolecular recognition site; other site 448385010110 dimerization interface [polypeptide binding]; other site 448385010111 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385010112 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010113 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010114 active site 448385010115 ATP binding site [chemical binding]; other site 448385010116 substrate binding site [chemical binding]; other site 448385010117 activation loop (A-loop); other site 448385010118 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 448385010119 Short C-terminal domain; Region: SHOCT; pfam09851 448385010120 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 448385010121 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 448385010122 Sporulation related domain; Region: SPOR; pfam05036 448385010123 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 448385010124 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385010125 DNA binding residues [nucleotide binding] 448385010126 Uncharacterized conserved protein [Function unknown]; Region: COG1359 448385010127 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 448385010128 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385010129 metal ion-dependent adhesion site (MIDAS); other site 448385010130 Predicted transcriptional regulator [Transcription]; Region: COG2378 448385010131 HTH domain; Region: HTH_11; pfam08279 448385010132 WYL domain; Region: WYL; pfam13280 448385010133 short chain dehydrogenase; Provisional; Region: PRK08303 448385010134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385010135 NAD(P) binding site [chemical binding]; other site 448385010136 active site 448385010137 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010138 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010139 active site 448385010140 ATP binding site [chemical binding]; other site 448385010141 substrate binding site [chemical binding]; other site 448385010142 activation loop (A-loop); other site 448385010143 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385010144 phosphopeptide binding site; other site 448385010145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385010146 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385010147 Walker A motif; other site 448385010148 ATP binding site [chemical binding]; other site 448385010149 Walker B motif; other site 448385010150 arginine finger; other site 448385010151 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 448385010152 Oligomerisation domain; Region: Oligomerisation; pfam02410 448385010153 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 448385010154 putative catalytic cysteine [active] 448385010155 GMP synthase; Reviewed; Region: guaA; PRK00074 448385010156 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 448385010157 AMP/PPi binding site [chemical binding]; other site 448385010158 candidate oxyanion hole; other site 448385010159 catalytic triad [active] 448385010160 potential glutamine specificity residues [chemical binding]; other site 448385010161 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 448385010162 ATP Binding subdomain [chemical binding]; other site 448385010163 Ligand Binding sites [chemical binding]; other site 448385010164 Dimerization subdomain; other site 448385010165 PEGA domain; Region: PEGA; pfam08308 448385010166 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385010167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385010168 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385010169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010171 active site 448385010172 ATP binding site [chemical binding]; other site 448385010173 substrate binding site [chemical binding]; other site 448385010174 activation loop (A-loop); other site 448385010175 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 448385010176 Ribosome-binding factor A; Region: RBFA; cl00542 448385010177 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 448385010178 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 448385010179 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 448385010180 active site 448385010181 catalytic triad [active] 448385010182 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 448385010183 PA/protease or protease-like domain interface [polypeptide binding]; other site 448385010184 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385010185 catalytic residues [active] 448385010186 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 448385010187 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385010188 Methyltransferase domain; Region: Methyltransf_11; pfam08241 448385010189 S-adenosylmethionine binding site [chemical binding]; other site 448385010190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385010191 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385010192 NAD(P) binding site [chemical binding]; other site 448385010193 active site 448385010194 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385010195 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 448385010196 putative C-terminal domain interface [polypeptide binding]; other site 448385010197 putative GSH binding site (G-site) [chemical binding]; other site 448385010198 putative dimer interface [polypeptide binding]; other site 448385010199 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 448385010200 putative substrate binding pocket (H-site) [chemical binding]; other site 448385010201 putative N-terminal domain interface [polypeptide binding]; other site 448385010202 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 448385010203 putative cation:proton antiport protein; Provisional; Region: PRK10669 448385010204 TrkA-N domain; Region: TrkA_N; pfam02254 448385010205 EamA-like transporter family; Region: EamA; pfam00892 448385010206 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 448385010207 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 448385010208 Permease; Region: Permease; pfam02405 448385010209 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 448385010210 Permease; Region: Permease; pfam02405 448385010211 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 448385010212 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 448385010213 Walker A/P-loop; other site 448385010214 ATP binding site [chemical binding]; other site 448385010215 Q-loop/lid; other site 448385010216 ABC transporter signature motif; other site 448385010217 Walker B; other site 448385010218 D-loop; other site 448385010219 H-loop/switch region; other site 448385010220 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 448385010221 mce related protein; Region: MCE; pfam02470 448385010222 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 448385010223 carboxyltransferase (CT) interaction site; other site 448385010224 biotinylation site [posttranslational modification]; other site 448385010225 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 448385010226 active site 448385010227 dimer interface [polypeptide binding]; other site 448385010228 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 448385010229 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 448385010230 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 448385010231 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 448385010232 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 448385010233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385010234 catalytic residue [active] 448385010235 Response regulator receiver domain; Region: Response_reg; pfam00072 448385010236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385010237 active site 448385010238 phosphorylation site [posttranslational modification] 448385010239 intermolecular recognition site; other site 448385010240 dimerization interface [polypeptide binding]; other site 448385010241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385010242 dimer interface [polypeptide binding]; other site 448385010243 phosphorylation site [posttranslational modification] 448385010244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385010245 ATP binding site [chemical binding]; other site 448385010246 Mg2+ binding site [ion binding]; other site 448385010247 G-X-G motif; other site 448385010248 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 448385010249 putative active site [active] 448385010250 catalytic triad [active] 448385010251 putative dimer interface [polypeptide binding]; other site 448385010252 Protein of unknown function DUF72; Region: DUF72; pfam01904 448385010253 RNase_H superfamily; Region: RNase_H_2; pfam13482 448385010254 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 448385010255 CoA-binding site [chemical binding]; other site 448385010256 PAS domain; Region: PAS; smart00091 448385010257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385010258 metal binding site [ion binding]; metal-binding site 448385010259 active site 448385010260 I-site; other site 448385010261 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 448385010262 Isochorismatase family; Region: Isochorismatase; pfam00857 448385010263 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 448385010264 catalytic triad [active] 448385010265 conserved cis-peptide bond; other site 448385010266 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 448385010267 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 448385010268 active site 448385010269 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 448385010270 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 448385010271 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 448385010272 homodimer interface [polypeptide binding]; other site 448385010273 NADP binding site [chemical binding]; other site 448385010274 substrate binding site [chemical binding]; other site 448385010275 Predicted methyltransferase [General function prediction only]; Region: COG3897 448385010276 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 448385010277 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385010278 Walker A/P-loop; other site 448385010279 ATP binding site [chemical binding]; other site 448385010280 Q-loop/lid; other site 448385010281 ABC transporter signature motif; other site 448385010282 Walker B; other site 448385010283 D-loop; other site 448385010284 H-loop/switch region; other site 448385010285 Protein of unknown function DUF72; Region: DUF72; pfam01904 448385010286 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 448385010287 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 448385010288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385010289 active site 448385010290 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010291 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010292 active site 448385010293 ATP binding site [chemical binding]; other site 448385010294 substrate binding site [chemical binding]; other site 448385010295 activation loop (A-loop); other site 448385010296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385010297 active site 448385010298 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385010299 I-site; other site 448385010300 metal binding site [ion binding]; metal-binding site 448385010301 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385010302 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385010303 active site 448385010304 DNA gyrase subunit A; Validated; Region: PRK05560 448385010305 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 448385010306 CAP-like domain; other site 448385010307 active site 448385010308 primary dimer interface [polypeptide binding]; other site 448385010309 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010310 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010311 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010312 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010313 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010314 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 448385010315 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 448385010316 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 448385010317 putative active site pocket [active] 448385010318 dimerization interface [polypeptide binding]; other site 448385010319 putative catalytic residue [active] 448385010320 Uncharacterized conserved protein [Function unknown]; Region: COG3268 448385010321 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385010322 Amidase; Region: Amidase; cl11426 448385010323 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 448385010324 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 448385010325 PYR/PP interface [polypeptide binding]; other site 448385010326 dimer interface [polypeptide binding]; other site 448385010327 TPP binding site [chemical binding]; other site 448385010328 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 448385010329 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 448385010330 TPP-binding site [chemical binding]; other site 448385010331 dimer interface [polypeptide binding]; other site 448385010332 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 448385010333 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 448385010334 putative valine binding site [chemical binding]; other site 448385010335 dimer interface [polypeptide binding]; other site 448385010336 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 448385010337 ketol-acid reductoisomerase; Provisional; Region: PRK05479 448385010338 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 448385010339 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 448385010340 2-isopropylmalate synthase; Validated; Region: PRK00915 448385010341 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 448385010342 active site 448385010343 catalytic residues [active] 448385010344 metal binding site [ion binding]; metal-binding site 448385010345 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 448385010346 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 448385010347 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 448385010348 active site 448385010349 catalytic residues [active] 448385010350 metal binding site [ion binding]; metal-binding site 448385010351 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 448385010352 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 448385010353 tartrate dehydrogenase; Region: TTC; TIGR02089 448385010354 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010355 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010356 active site 448385010357 ATP binding site [chemical binding]; other site 448385010358 substrate binding site [chemical binding]; other site 448385010359 activation loop (A-loop); other site 448385010360 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 448385010361 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 448385010362 FMN binding site [chemical binding]; other site 448385010363 active site 448385010364 catalytic residues [active] 448385010365 substrate binding site [chemical binding]; other site 448385010366 5' nucleotidase family; Region: 5_nucleotid; cl17687 448385010367 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385010368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 448385010369 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 448385010370 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 448385010371 ATP binding site [chemical binding]; other site 448385010372 Mg2+ binding site [ion binding]; other site 448385010373 G-X-G motif; other site 448385010374 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 448385010375 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 448385010376 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 448385010377 Substrate binding site; other site 448385010378 Mg++ binding site; other site 448385010379 metal-binding site 448385010380 Mg++ binding site; other site 448385010381 metal-binding site 448385010382 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 448385010383 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 448385010384 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 448385010385 dimer interface [polypeptide binding]; other site 448385010386 active site 448385010387 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 448385010388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385010389 active site 448385010390 motif I; other site 448385010391 motif II; other site 448385010392 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385010393 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 448385010394 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 448385010395 active site 448385010396 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 448385010397 generic binding surface II; other site 448385010398 generic binding surface I; other site 448385010399 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385010400 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385010401 ligand binding site [chemical binding]; other site 448385010402 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385010403 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 448385010404 metal binding triad [ion binding]; metal-binding site 448385010405 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385010406 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385010407 ligand binding site [chemical binding]; other site 448385010408 flexible hinge region; other site 448385010409 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 448385010410 putative switch regulator; other site 448385010411 non-specific DNA interactions [nucleotide binding]; other site 448385010412 DNA binding site [nucleotide binding] 448385010413 sequence specific DNA binding site [nucleotide binding]; other site 448385010414 putative cAMP binding site [chemical binding]; other site 448385010415 Protein of unknown function (DUF507); Region: DUF507; cl01112 448385010416 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 448385010417 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 448385010418 NAD binding site [chemical binding]; other site 448385010419 substrate binding site [chemical binding]; other site 448385010420 homodimer interface [polypeptide binding]; other site 448385010421 active site 448385010422 hypothetical protein; Provisional; Region: PRK11820 448385010423 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 448385010424 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 448385010425 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 448385010426 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 448385010427 catalytic site [active] 448385010428 G-X2-G-X-G-K; other site 448385010429 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 448385010430 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 448385010431 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 448385010432 substrate binding site [chemical binding]; other site 448385010433 ATP binding site [chemical binding]; other site 448385010434 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010435 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010436 active site 448385010437 ATP binding site [chemical binding]; other site 448385010438 substrate binding site [chemical binding]; other site 448385010439 activation loop (A-loop); other site 448385010440 prolyl-tRNA synthetase; Provisional; Region: PRK08661 448385010441 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 448385010442 dimer interface [polypeptide binding]; other site 448385010443 motif 1; other site 448385010444 active site 448385010445 motif 2; other site 448385010446 motif 3; other site 448385010447 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 448385010448 anticodon binding site; other site 448385010449 zinc-binding site [ion binding]; other site 448385010450 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 448385010451 active site 448385010452 catalytic nucleophile [active] 448385010453 dimer interface [polypeptide binding]; other site 448385010454 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 448385010455 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385010456 hydroxyglutarate oxidase; Provisional; Region: PRK11728 448385010457 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385010458 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385010459 phosphopeptide binding site; other site 448385010460 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 448385010461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385010462 Walker A motif; other site 448385010463 ATP binding site [chemical binding]; other site 448385010464 Walker B motif; other site 448385010465 arginine finger; other site 448385010466 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385010467 conserved cys residue [active] 448385010468 Phosphoesterase family; Region: Phosphoesterase; pfam04185 448385010469 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 448385010470 MviN-like protein; Region: MVIN; pfam03023 448385010471 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 448385010472 active site 448385010473 catalytic residues [active] 448385010474 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 448385010475 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 448385010476 active site 448385010477 PrkA AAA domain; Region: AAA_PrkA; smart00763 448385010478 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 448385010479 Protein kinase domain; Region: Pkinase; pfam00069 448385010480 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010481 active site 448385010482 ATP binding site [chemical binding]; other site 448385010483 substrate binding site [chemical binding]; other site 448385010484 activation loop (A-loop); other site 448385010485 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 448385010486 Putative zinc ribbon domain; Region: DUF164; pfam02591 448385010487 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385010488 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385010489 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 448385010490 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385010491 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385010492 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 448385010493 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 448385010494 Helix-turn-helix domain; Region: HTH_17; pfam12728 448385010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385010496 Response regulator receiver domain; Region: Response_reg; pfam00072 448385010497 active site 448385010498 phosphorylation site [posttranslational modification] 448385010499 intermolecular recognition site; other site 448385010500 dimerization interface [polypeptide binding]; other site 448385010501 AMIN domain; Region: AMIN; pfam11741 448385010502 AMIN domain; Region: AMIN; pfam11741 448385010503 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 448385010504 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 448385010505 active site 448385010506 metal binding site [ion binding]; metal-binding site 448385010507 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 448385010508 TPR repeat; Region: TPR_11; pfam13414 448385010509 PEGA domain; Region: PEGA; pfam08308 448385010510 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 448385010511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385010512 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385010513 Walker A motif; other site 448385010514 ATP binding site [chemical binding]; other site 448385010515 Walker B motif; other site 448385010516 arginine finger; other site 448385010517 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385010518 Protein phosphatase 2C; Region: PP2C; pfam00481 448385010519 active site 448385010520 Double zinc ribbon; Region: DZR; pfam12773 448385010521 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 448385010522 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385010523 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010524 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010525 active site 448385010526 ATP binding site [chemical binding]; other site 448385010527 substrate binding site [chemical binding]; other site 448385010528 activation loop (A-loop); other site 448385010529 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 448385010530 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 448385010531 tetramer interface [polypeptide binding]; other site 448385010532 TPP-binding site [chemical binding]; other site 448385010533 heterodimer interface [polypeptide binding]; other site 448385010534 phosphorylation loop region [posttranslational modification] 448385010535 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 448385010536 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 448385010537 alpha subunit interface [polypeptide binding]; other site 448385010538 TPP binding site [chemical binding]; other site 448385010539 heterodimer interface [polypeptide binding]; other site 448385010540 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 448385010541 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 448385010542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 448385010543 E3 interaction surface; other site 448385010544 lipoyl attachment site [posttranslational modification]; other site 448385010545 e3 binding domain; Region: E3_binding; pfam02817 448385010546 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 448385010547 TIR domain; Region: TIR_2; cl17458 448385010548 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010550 TPR motif; other site 448385010551 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010552 binding surface 448385010553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010554 TPR motif; other site 448385010555 binding surface 448385010556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010558 binding surface 448385010559 TPR motif; other site 448385010560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010563 binding surface 448385010564 TPR motif; other site 448385010565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385010566 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 448385010567 SIR2-like domain; Region: SIR2_2; pfam13289 448385010568 TIR domain; Region: TIR_2; pfam13676 448385010569 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385010570 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385010571 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 448385010572 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 448385010573 putative active site [active] 448385010574 putative metal binding site [ion binding]; other site 448385010575 cyclic 3',5'-adenosine monophosphate phosphodiesterase; Provisional; Region: PRK11148 448385010576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 448385010577 DNA-binding site [nucleotide binding]; DNA binding site 448385010578 RNA-binding motif; other site 448385010579 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 448385010580 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385010581 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385010582 Walker A motif; other site 448385010583 ATP binding site [chemical binding]; other site 448385010584 Walker B motif; other site 448385010585 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 448385010586 active site 448385010587 catalytic residues [active] 448385010588 metal binding site [ion binding]; metal-binding site 448385010589 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 448385010590 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 448385010591 catalytic motif [active] 448385010592 Zn binding site [ion binding]; other site 448385010593 RibD C-terminal domain; Region: RibD_C; cl17279 448385010594 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 448385010595 ATP cone domain; Region: ATP-cone; pfam03477 448385010596 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 448385010597 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 448385010598 dimer interface [polypeptide binding]; other site 448385010599 active site 448385010600 acyl carrier protein; Provisional; Region: acpP; PRK00982 448385010601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385010602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385010603 NAD(P) binding site [chemical binding]; other site 448385010604 active site 448385010605 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 448385010606 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385010607 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 448385010608 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 448385010609 dimer interface [polypeptide binding]; other site 448385010610 active site 448385010611 CoA binding pocket [chemical binding]; other site 448385010612 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 448385010613 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 448385010614 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385010615 active site 448385010616 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 448385010617 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 448385010618 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 448385010619 NAD synthetase; Reviewed; Region: nadE; PRK00876 448385010620 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 448385010621 Ligand Binding Site [chemical binding]; other site 448385010622 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 448385010623 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 448385010624 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385010625 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 448385010626 acyl-activating enzyme (AAE) consensus motif; other site 448385010627 putative AMP binding site [chemical binding]; other site 448385010628 putative active site [active] 448385010629 putative CoA binding site [chemical binding]; other site 448385010630 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 448385010631 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 448385010632 active site 448385010633 dimer interface [polypeptide binding]; other site 448385010634 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 448385010635 Ligand Binding Site [chemical binding]; other site 448385010636 Molecular Tunnel; other site 448385010637 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 448385010638 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010639 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010640 active site 448385010641 ATP binding site [chemical binding]; other site 448385010642 substrate binding site [chemical binding]; other site 448385010643 activation loop (A-loop); other site 448385010644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010645 TPR repeat; Region: TPR_11; pfam13414 448385010646 binding surface 448385010647 TPR motif; other site 448385010648 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385010649 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385010650 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385010651 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385010652 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385010653 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385010654 GTP-binding protein LepA; Provisional; Region: PRK05433 448385010655 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 448385010656 G1 box; other site 448385010657 putative GEF interaction site [polypeptide binding]; other site 448385010658 GTP/Mg2+ binding site [chemical binding]; other site 448385010659 Switch I region; other site 448385010660 G2 box; other site 448385010661 G3 box; other site 448385010662 Switch II region; other site 448385010663 G4 box; other site 448385010664 G5 box; other site 448385010665 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 448385010666 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 448385010667 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 448385010668 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 448385010669 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 448385010670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385010671 RNA binding surface [nucleotide binding]; other site 448385010672 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 448385010673 active site 448385010674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385010675 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385010676 Walker A motif; other site 448385010677 ATP binding site [chemical binding]; other site 448385010678 Walker B motif; other site 448385010679 arginine finger; other site 448385010680 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385010681 phosphopeptide binding site; other site 448385010682 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385010683 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 448385010684 putative ligand binding pocket/active site [active] 448385010685 putative metal binding site [ion binding]; other site 448385010686 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 448385010687 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385010688 Zn2+ binding site [ion binding]; other site 448385010689 Mg2+ binding site [ion binding]; other site 448385010690 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 448385010691 synthetase active site [active] 448385010692 NTP binding site [chemical binding]; other site 448385010693 metal binding site [ion binding]; metal-binding site 448385010694 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 448385010695 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 448385010696 coproporphyrinogen III oxidase; Validated; Region: PRK05628 448385010697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385010698 FeS/SAM binding site; other site 448385010699 serine racemase; Region: PLN02970 448385010700 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 448385010701 tetramer interface [polypeptide binding]; other site 448385010702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385010703 catalytic residue [active] 448385010704 Predicted amidohydrolase [General function prediction only]; Region: COG0388 448385010705 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 448385010706 active site 448385010707 catalytic triad [active] 448385010708 dimer interface [polypeptide binding]; other site 448385010709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385010710 Response regulator receiver domain; Region: Response_reg; pfam00072 448385010711 active site 448385010712 phosphorylation site [posttranslational modification] 448385010713 intermolecular recognition site; other site 448385010714 dimerization interface [polypeptide binding]; other site 448385010715 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010716 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010717 active site 448385010718 ATP binding site [chemical binding]; other site 448385010719 substrate binding site [chemical binding]; other site 448385010720 activation loop (A-loop); other site 448385010721 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 448385010722 cyclase homology domain; Region: CHD; cd07302 448385010723 nucleotidyl binding site; other site 448385010724 metal binding site [ion binding]; metal-binding site 448385010725 dimer interface [polypeptide binding]; other site 448385010726 AAA ATPase domain; Region: AAA_16; pfam13191 448385010727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010728 TPR motif; other site 448385010729 binding surface 448385010730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385010731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385010732 catalytic residue [active] 448385010733 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385010734 MarR family; Region: MarR_2; pfam12802 448385010735 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 448385010736 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 448385010737 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 448385010738 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 448385010739 active site residue [active] 448385010740 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 448385010741 ATP binding site [chemical binding]; other site 448385010742 substrate interface [chemical binding]; other site 448385010743 TPR repeat; Region: TPR_11; pfam13414 448385010744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010745 binding surface 448385010746 TPR motif; other site 448385010747 TPR repeat; Region: TPR_11; pfam13414 448385010748 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 448385010749 Nudix hydrolase homolog; Region: PLN02791 448385010750 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 448385010751 putative active site [active] 448385010752 putative metal binding site [ion binding]; other site 448385010753 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385010754 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385010755 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385010756 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385010757 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385010758 putative active site [active] 448385010759 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 448385010760 hydrophobic ligand binding site; other site 448385010761 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385010762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385010763 non-specific DNA binding site [nucleotide binding]; other site 448385010764 salt bridge; other site 448385010765 sequence-specific DNA binding site [nucleotide binding]; other site 448385010766 AAA ATPase domain; Region: AAA_16; pfam13191 448385010767 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 448385010768 NAD-dependent deacetylase; Provisional; Region: PRK00481 448385010769 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 448385010770 ATP cone domain; Region: ATP-cone; pfam03477 448385010771 Class I ribonucleotide reductase; Region: RNR_I; cd01679 448385010772 active site 448385010773 dimer interface [polypeptide binding]; other site 448385010774 catalytic residues [active] 448385010775 effector binding site; other site 448385010776 R2 peptide binding site; other site 448385010777 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 448385010778 dimer interface [polypeptide binding]; other site 448385010779 putative radical transfer pathway; other site 448385010780 diiron center [ion binding]; other site 448385010781 tyrosyl radical; other site 448385010782 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385010783 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 448385010784 isochorismate synthase DhbC; Validated; Region: PRK06923 448385010785 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 448385010786 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 448385010787 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 448385010788 acyl-activating enzyme (AAE) consensus motif; other site 448385010789 active site 448385010790 AMP binding site [chemical binding]; other site 448385010791 substrate binding site [chemical binding]; other site 448385010792 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 448385010793 Isochorismatase family; Region: Isochorismatase; pfam00857 448385010794 catalytic triad [active] 448385010795 conserved cis-peptide bond; other site 448385010796 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 448385010797 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 448385010798 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 448385010799 FAD binding pocket [chemical binding]; other site 448385010800 FAD binding motif [chemical binding]; other site 448385010801 phosphate binding motif [ion binding]; other site 448385010802 NAD binding pocket [chemical binding]; other site 448385010803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385010804 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 448385010805 NAD(P) binding site [chemical binding]; other site 448385010806 active site 448385010807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 448385010808 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385010809 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 448385010810 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385010811 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 448385010812 N-terminal plug; other site 448385010813 ligand-binding site [chemical binding]; other site 448385010814 Condensation domain; Region: Condensation; pfam00668 448385010815 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385010816 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 448385010817 acyl-activating enzyme (AAE) consensus motif; other site 448385010818 AMP binding site [chemical binding]; other site 448385010819 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385010820 thioester reductase domain; Region: Thioester-redct; TIGR01746 448385010821 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 448385010822 putative NAD(P) binding site [chemical binding]; other site 448385010823 active site 448385010824 putative substrate binding site [chemical binding]; other site 448385010825 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 448385010826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385010827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385010828 catalytic residue [active] 448385010829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385010830 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385010831 putative substrate translocation pore; other site 448385010832 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385010833 substrate binding sites [chemical binding]; other site 448385010834 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 448385010835 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385010836 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385010837 ligand binding site [chemical binding]; other site 448385010838 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 448385010839 putative active site [active] 448385010840 putative metal binding site [ion binding]; other site 448385010841 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385010842 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 448385010843 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 448385010844 twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410 448385010845 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 448385010846 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 448385010847 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 448385010848 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 448385010849 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 448385010850 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 448385010851 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385010852 ATP binding site [chemical binding]; other site 448385010853 putative Mg++ binding site [ion binding]; other site 448385010854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385010855 nucleotide binding region [chemical binding]; other site 448385010856 ATP-binding site [chemical binding]; other site 448385010857 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 448385010858 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010860 active site 448385010861 ATP binding site [chemical binding]; other site 448385010862 substrate binding site [chemical binding]; other site 448385010863 activation loop (A-loop); other site 448385010864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385010865 S-adenosylmethionine binding site [chemical binding]; other site 448385010866 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385010867 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385010868 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 448385010869 active site 448385010870 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385010871 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385010872 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385010873 Septum formation initiator; Region: DivIC; pfam04977 448385010874 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010875 active site 448385010876 ATP binding site [chemical binding]; other site 448385010877 substrate binding site [chemical binding]; other site 448385010878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385010879 TPR motif; other site 448385010880 binding surface 448385010881 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 448385010882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385010883 TPR motif; other site 448385010884 binding surface 448385010885 Fic family protein [Function unknown]; Region: COG3177 448385010886 Fic/DOC family; Region: Fic; pfam02661 448385010887 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 448385010888 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385010889 minor groove reading motif; other site 448385010890 helix-hairpin-helix signature motif; other site 448385010891 substrate binding pocket [chemical binding]; other site 448385010892 active site 448385010893 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385010894 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 448385010895 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 448385010896 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 448385010897 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 448385010898 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 448385010899 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 448385010900 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 448385010901 FAD binding pocket [chemical binding]; other site 448385010902 FAD binding motif [chemical binding]; other site 448385010903 phosphate binding motif [ion binding]; other site 448385010904 beta-alpha-beta structure motif; other site 448385010905 NAD binding pocket [chemical binding]; other site 448385010906 Iron coordination center [ion binding]; other site 448385010907 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 448385010908 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385010909 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385010910 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 448385010911 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 448385010912 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 448385010913 carboxyltransferase (CT) interaction site; other site 448385010914 biotinylation site [posttranslational modification]; other site 448385010915 Dehydroquinase class II; Region: DHquinase_II; pfam01220 448385010916 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 448385010917 trimer interface [polypeptide binding]; other site 448385010918 active site 448385010919 dimer interface [polypeptide binding]; other site 448385010920 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 448385010921 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 448385010922 substrate binding site [chemical binding]; other site 448385010923 ligand binding site [chemical binding]; other site 448385010924 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385010925 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385010926 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 448385010927 Sulfatase; Region: Sulfatase; pfam00884 448385010928 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 448385010929 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385010930 minor groove reading motif; other site 448385010931 helix-hairpin-helix signature motif; other site 448385010932 substrate binding pocket [chemical binding]; other site 448385010933 active site 448385010934 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 448385010935 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 448385010936 DNA binding and oxoG recognition site [nucleotide binding] 448385010937 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 448385010938 GAF domain; Region: GAF_2; pfam13185 448385010939 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385010940 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385010941 dimer interface [polypeptide binding]; other site 448385010942 phosphorylation site [posttranslational modification] 448385010943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385010944 ATP binding site [chemical binding]; other site 448385010945 G-X-G motif; other site 448385010946 Response regulator receiver domain; Region: Response_reg; pfam00072 448385010947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385010948 active site 448385010949 phosphorylation site [posttranslational modification] 448385010950 intermolecular recognition site; other site 448385010951 dimerization interface [polypeptide binding]; other site 448385010952 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010953 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010954 active site 448385010955 ATP binding site [chemical binding]; other site 448385010956 substrate binding site [chemical binding]; other site 448385010957 activation loop (A-loop); other site 448385010958 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385010959 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385010960 Protein kinase domain; Region: Pkinase; pfam00069 448385010961 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010962 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385010963 active site 448385010964 ATP binding site [chemical binding]; other site 448385010965 substrate binding site [chemical binding]; other site 448385010966 activation loop (A-loop); other site 448385010967 Predicted membrane protein [Function unknown]; Region: COG2261 448385010968 Protein kinase domain; Region: Pkinase; pfam00069 448385010969 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010970 active site 448385010971 ATP binding site [chemical binding]; other site 448385010972 substrate binding site [chemical binding]; other site 448385010973 activation loop (A-loop); other site 448385010974 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 448385010975 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 448385010976 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 448385010977 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 448385010978 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 448385010979 putative active site [active] 448385010980 metal binding site [ion binding]; metal-binding site 448385010981 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 448385010982 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 448385010983 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385010984 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385010985 active site 448385010986 ATP binding site [chemical binding]; other site 448385010987 substrate binding site [chemical binding]; other site 448385010988 activation loop (A-loop); other site 448385010989 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 448385010990 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 448385010991 putative active site [active] 448385010992 putative metal binding site [ion binding]; other site 448385010993 Putative addiction module component; Region: Unstab_antitox; pfam09720 448385010994 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 448385010995 putative active site [active] 448385010996 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385010997 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385010998 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 448385010999 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 448385011000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385011001 Walker A/P-loop; other site 448385011002 ATP binding site [chemical binding]; other site 448385011003 Q-loop/lid; other site 448385011004 ABC transporter signature motif; other site 448385011005 Walker B; other site 448385011006 D-loop; other site 448385011007 H-loop/switch region; other site 448385011008 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 448385011009 putative acyl-acceptor binding pocket; other site 448385011010 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 448385011011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011012 active site 448385011013 phosphorylation site [posttranslational modification] 448385011014 intermolecular recognition site; other site 448385011015 dimerization interface [polypeptide binding]; other site 448385011016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385011017 DNA binding residues [nucleotide binding] 448385011018 dimerization interface [polypeptide binding]; other site 448385011019 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 448385011020 active site 448385011021 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385011022 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385011023 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385011024 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 448385011025 ATP binding site [chemical binding]; other site 448385011026 putative Mg++ binding site [ion binding]; other site 448385011027 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385011028 nucleotide binding region [chemical binding]; other site 448385011029 ATP-binding site [chemical binding]; other site 448385011030 DEAD/H associated; Region: DEAD_assoc; pfam08494 448385011031 HEAT repeats; Region: HEAT_2; pfam13646 448385011032 HEAT repeats; Region: HEAT_2; pfam13646 448385011033 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 448385011034 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 448385011035 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 448385011036 active site 448385011037 Zn binding site [ion binding]; other site 448385011038 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 448385011039 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385011040 metal binding site [ion binding]; metal-binding site 448385011041 PEGA domain; Region: PEGA; pfam08308 448385011042 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 448385011043 phosphate binding site [ion binding]; other site 448385011044 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 448385011045 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 448385011046 nucleotide binding site [chemical binding]; other site 448385011047 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385011048 SBD interface [polypeptide binding]; other site 448385011049 PAS fold; Region: PAS_4; pfam08448 448385011050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385011051 putative active site [active] 448385011052 heme pocket [chemical binding]; other site 448385011053 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011054 Membrane transport protein; Region: Mem_trans; cl09117 448385011055 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 448385011056 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 448385011057 TPP-binding site [chemical binding]; other site 448385011058 dimer interface [polypeptide binding]; other site 448385011059 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 448385011060 PYR/PP interface [polypeptide binding]; other site 448385011061 dimer interface [polypeptide binding]; other site 448385011062 TPP binding site [chemical binding]; other site 448385011063 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 448385011064 Response regulator receiver domain; Region: Response_reg; pfam00072 448385011065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011066 active site 448385011067 phosphorylation site [posttranslational modification] 448385011068 intermolecular recognition site; other site 448385011069 dimerization interface [polypeptide binding]; other site 448385011070 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011072 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385011073 active site 448385011074 ATP binding site [chemical binding]; other site 448385011075 substrate binding site [chemical binding]; other site 448385011076 activation loop (A-loop); other site 448385011077 Predicted ATPase [General function prediction only]; Region: COG3899 448385011078 AAA ATPase domain; Region: AAA_16; pfam13191 448385011079 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385011080 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385011081 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385011082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385011083 dimer interface [polypeptide binding]; other site 448385011084 phosphorylation site [posttranslational modification] 448385011085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385011086 ATP binding site [chemical binding]; other site 448385011087 Mg2+ binding site [ion binding]; other site 448385011088 G-X-G motif; other site 448385011089 Response regulator receiver domain; Region: Response_reg; pfam00072 448385011090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011091 active site 448385011092 phosphorylation site [posttranslational modification] 448385011093 intermolecular recognition site; other site 448385011094 dimerization interface [polypeptide binding]; other site 448385011095 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385011096 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 448385011097 FG-GAP repeat; Region: FG-GAP; pfam01839 448385011098 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385011099 glutathionine S-transferase; Provisional; Region: PRK10542 448385011100 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 448385011101 C-terminal domain interface [polypeptide binding]; other site 448385011102 GSH binding site (G-site) [chemical binding]; other site 448385011103 dimer interface [polypeptide binding]; other site 448385011104 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 448385011105 dimer interface [polypeptide binding]; other site 448385011106 N-terminal domain interface [polypeptide binding]; other site 448385011107 substrate binding pocket (H-site) [chemical binding]; other site 448385011108 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 448385011109 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385011110 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385011111 non-specific DNA binding site [nucleotide binding]; other site 448385011112 salt bridge; other site 448385011113 sequence-specific DNA binding site [nucleotide binding]; other site 448385011114 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011115 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011116 active site 448385011117 ATP binding site [chemical binding]; other site 448385011118 substrate binding site [chemical binding]; other site 448385011119 activation loop (A-loop); other site 448385011120 Response regulator receiver domain; Region: Response_reg; pfam00072 448385011121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011122 active site 448385011123 phosphorylation site [posttranslational modification] 448385011124 intermolecular recognition site; other site 448385011125 dimerization interface [polypeptide binding]; other site 448385011126 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385011127 cyclase homology domain; Region: CHD; cd07302 448385011128 nucleotidyl binding site; other site 448385011129 metal binding site [ion binding]; metal-binding site 448385011130 dimer interface [polypeptide binding]; other site 448385011131 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385011132 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385011133 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 448385011134 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385011135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011136 S-adenosylmethionine binding site [chemical binding]; other site 448385011137 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 448385011138 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 448385011139 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 448385011140 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 448385011141 Cellulose binding domain; Region: CBM_3; pfam00942 448385011142 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 448385011143 active site 448385011144 catalytic residues [active] 448385011145 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385011146 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385011147 phosphopeptide binding site; other site 448385011148 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385011149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385011150 Walker A motif; other site 448385011151 ATP binding site [chemical binding]; other site 448385011152 Walker B motif; other site 448385011153 arginine finger; other site 448385011154 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 448385011155 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 448385011156 aromatic chitin/cellulose binding site residues [chemical binding]; other site 448385011157 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 448385011158 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 448385011159 active site 448385011160 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011161 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011162 active site 448385011163 ATP binding site [chemical binding]; other site 448385011164 substrate binding site [chemical binding]; other site 448385011165 activation loop (A-loop); other site 448385011166 Cadmium resistance transporter; Region: Cad; pfam03596 448385011167 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 448385011168 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 448385011169 metal-binding site [ion binding] 448385011170 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 448385011171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385011172 Soluble P-type ATPase [General function prediction only]; Region: COG4087 448385011173 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 448385011174 active site 448385011175 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385011176 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385011177 putative sugar binding sites [chemical binding]; other site 448385011178 Q-X-W motif; other site 448385011179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385011180 NADH(P)-binding; Region: NAD_binding_10; pfam13460 448385011181 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385011182 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385011183 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385011184 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385011185 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385011186 PKD domain; Region: PKD; pfam00801 448385011187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385011188 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385011189 putative active site [active] 448385011190 heme pocket [chemical binding]; other site 448385011191 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011192 urate oxidase; Region: urate_oxi; TIGR03383 448385011193 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 448385011194 active site 448385011195 B12 binding domain; Region: B12-binding_2; pfam02607 448385011196 B12 binding domain; Region: B12-binding; pfam02310 448385011197 B12 binding site [chemical binding]; other site 448385011198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385011199 dimer interface [polypeptide binding]; other site 448385011200 phosphorylation site [posttranslational modification] 448385011201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385011202 ATP binding site [chemical binding]; other site 448385011203 Mg2+ binding site [ion binding]; other site 448385011204 G-X-G motif; other site 448385011205 Response regulator receiver domain; Region: Response_reg; pfam00072 448385011206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011207 active site 448385011208 phosphorylation site [posttranslational modification] 448385011209 intermolecular recognition site; other site 448385011210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385011211 dimerization interface [polypeptide binding]; other site 448385011212 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 448385011213 dimer interface [polypeptide binding]; other site 448385011214 phosphorylation site [posttranslational modification] 448385011215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385011216 ATP binding site [chemical binding]; other site 448385011217 Mg2+ binding site [ion binding]; other site 448385011218 G-X-G motif; other site 448385011219 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 448385011220 Domain interface; other site 448385011221 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 448385011222 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385011223 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 448385011224 starch-binding site 2 [chemical binding]; other site 448385011225 starch-binding site 1 [chemical binding]; other site 448385011226 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385011227 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385011228 TM-ABC transporter signature motif; other site 448385011229 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385011230 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385011231 Walker A/P-loop; other site 448385011232 ATP binding site [chemical binding]; other site 448385011233 Q-loop/lid; other site 448385011234 ABC transporter signature motif; other site 448385011235 Walker B; other site 448385011236 D-loop; other site 448385011237 H-loop/switch region; other site 448385011238 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385011239 Periplasmic sugar-binding domain of Thermotoga maritima glucose-binding protein (tmGBP) and its close homologs; Region: PBP1_tmGBP; cd06314 448385011240 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385011241 ligand binding site [chemical binding]; other site 448385011242 dimerization interface [polypeptide binding]; other site 448385011243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011245 active site 448385011246 ATP binding site [chemical binding]; other site 448385011247 substrate binding site [chemical binding]; other site 448385011248 activation loop (A-loop); other site 448385011249 Predicted ATPase [General function prediction only]; Region: COG3899 448385011250 AAA ATPase domain; Region: AAA_16; pfam13191 448385011251 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385011252 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385011253 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011254 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385011255 metal ion-dependent adhesion site (MIDAS); other site 448385011256 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385011257 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385011258 Walker A/P-loop; other site 448385011259 ATP binding site [chemical binding]; other site 448385011260 Q-loop/lid; other site 448385011261 ABC transporter signature motif; other site 448385011262 Walker B; other site 448385011263 D-loop; other site 448385011264 H-loop/switch region; other site 448385011265 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385011266 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385011267 Walker A/P-loop; other site 448385011268 ATP binding site [chemical binding]; other site 448385011269 Q-loop/lid; other site 448385011270 ABC transporter signature motif; other site 448385011271 Walker B; other site 448385011272 D-loop; other site 448385011273 H-loop/switch region; other site 448385011274 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385011275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385011276 dimer interface [polypeptide binding]; other site 448385011277 conserved gate region; other site 448385011278 putative PBP binding loops; other site 448385011279 ABC-ATPase subunit interface; other site 448385011280 NMT1-like family; Region: NMT1_2; pfam13379 448385011281 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 448385011282 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 448385011283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385011284 Cytochrome c; Region: Cytochrom_C; pfam00034 448385011285 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385011286 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385011287 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 448385011288 active site flap/lid [active] 448385011289 nucleophilic elbow; other site 448385011290 catalytic triad [active] 448385011291 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 448385011292 Family description; Region: VCBS; pfam13517 448385011293 Family description; Region: VCBS; pfam13517 448385011294 Family description; Region: VCBS; pfam13517 448385011295 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 448385011296 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 448385011297 catalytic residues [active] 448385011298 catalytic nucleophile [active] 448385011299 Recombinase; Region: Recombinase; pfam07508 448385011300 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 448385011301 Recombinase; Region: Recombinase; pfam07508 448385011302 Helix-turn-helix domain; Region: HTH_28; pfam13518 448385011303 Winged helix-turn helix; Region: HTH_29; pfam13551 448385011304 Homeodomain-like domain; Region: HTH_32; pfam13565 448385011305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 448385011306 Integrase core domain; Region: rve; pfam00665 448385011307 Integrase core domain; Region: rve_3; pfam13683 448385011308 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385011309 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 448385011310 ligand binding site [chemical binding]; other site 448385011311 dimer interface [polypeptide binding]; other site 448385011312 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011313 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011314 active site 448385011315 ATP binding site [chemical binding]; other site 448385011316 substrate binding site [chemical binding]; other site 448385011317 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385011318 activation loop (A-loop); other site 448385011319 activation loop (A-loop); other site 448385011320 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385011321 PQQ-like domain; Region: PQQ_2; pfam13360 448385011322 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385011323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011324 S-adenosylmethionine binding site [chemical binding]; other site 448385011325 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 448385011326 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385011327 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385011328 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385011329 AAA domain; Region: AAA_21; pfam13304 448385011330 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 448385011331 active site 448385011332 metal binding site [ion binding]; metal-binding site 448385011333 ERCC4 domain; Region: ERCC4; smart00891 448385011334 Phage associated DNA primase [General function prediction only]; Region: COG3378 448385011335 D5 N terminal like; Region: D5_N; pfam08706 448385011336 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 448385011337 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385011338 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385011339 phosphopeptide binding site; other site 448385011340 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385011341 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385011342 Walker A motif; other site 448385011343 ATP binding site [chemical binding]; other site 448385011344 Walker B motif; other site 448385011345 arginine finger; other site 448385011346 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385011347 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 448385011348 MG2 domain; Region: A2M_N; pfam01835 448385011349 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 448385011350 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 448385011351 Alpha-2-macroglobulin family; Region: A2M; pfam00207 448385011352 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 448385011353 surface patch; other site 448385011354 thioester region; other site 448385011355 A-macroglobulin complement component; Region: A2M_comp; pfam07678 448385011356 specificity defining residues; other site 448385011357 A-macroglobulin receptor; Region: A2M_recep; pfam07677 448385011358 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 448385011359 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 448385011360 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 448385011361 NAD(P) binding pocket [chemical binding]; other site 448385011362 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385011363 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011364 active site 448385011365 ATP binding site [chemical binding]; other site 448385011366 substrate binding site [chemical binding]; other site 448385011367 activation loop (A-loop); other site 448385011368 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 448385011369 5-oxoprolinase; Region: PLN02666 448385011370 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 448385011371 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 448385011372 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 448385011373 mannonate dehydratase; Provisional; Region: PRK03906 448385011374 mannonate dehydratase; Region: uxuA; TIGR00695 448385011375 putative pectinesterase; Region: PLN02432; cl01911 448385011376 putative pectinesterase; Region: PLN02432; cl01911 448385011377 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 448385011378 CoA binding domain; Region: CoA_binding_2; pfam13380 448385011379 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 448385011380 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 448385011381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 448385011382 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385011383 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385011384 TIGR02646 family protein; Region: TIGR02646 448385011385 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385011386 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385011387 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385011388 RHS Repeat; Region: RHS_repeat; pfam05593 448385011389 RHS Repeat; Region: RHS_repeat; pfam05593 448385011390 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385011391 RHS Repeat; Region: RHS_repeat; pfam05593 448385011392 RHS Repeat; Region: RHS_repeat; pfam05593 448385011393 RHS Repeat; Region: RHS_repeat; pfam05593 448385011394 RHS Repeat; Region: RHS_repeat; cl11982 448385011395 RHS Repeat; Region: RHS_repeat; cl11982 448385011396 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385011397 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 448385011398 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385011399 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385011400 structural tetrad; other site 448385011401 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385011402 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385011403 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385011404 cyclase homology domain; Region: CHD; cd07302 448385011405 nucleotidyl binding site; other site 448385011406 metal binding site [ion binding]; metal-binding site 448385011407 dimer interface [polypeptide binding]; other site 448385011408 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 448385011409 heme-binding site [chemical binding]; other site 448385011410 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011411 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 448385011412 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 448385011413 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385011414 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385011415 reactive center loop; other site 448385011416 CotH protein; Region: CotH; pfam08757 448385011417 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cl00097 448385011418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 448385011419 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385011420 DNA binding residues [nucleotide binding] 448385011421 dimerization interface [polypeptide binding]; other site 448385011422 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385011423 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 448385011424 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 448385011425 putative active site [active] 448385011426 putative metal binding site [ion binding]; other site 448385011427 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 448385011428 Domain interface; other site 448385011429 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 448385011430 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385011431 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385011432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385011433 Organic Anion Transporter Polypeptide (OATP) family; Region: OATP; pfam03137 448385011434 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385011435 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385011436 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385011437 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385011438 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385011439 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385011440 RHS Repeat; Region: RHS_repeat; cl11982 448385011441 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385011442 RHS Repeat; Region: RHS_repeat; pfam05593 448385011443 RHS Repeat; Region: RHS_repeat; pfam05593 448385011444 RHS Repeat; Region: RHS_repeat; cl11982 448385011445 RHS protein; Region: RHS; pfam03527 448385011446 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385011447 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385011448 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385011449 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385011450 large tegument protein UL36; Provisional; Region: PHA03247 448385011451 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 448385011452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385011453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385011454 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385011455 dimerization interface [polypeptide binding]; other site 448385011456 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 448385011457 nucleoside/Zn binding site; other site 448385011458 dimer interface [polypeptide binding]; other site 448385011459 catalytic motif [active] 448385011460 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 448385011461 T5orf172 domain; Region: T5orf172; pfam10544 448385011462 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385011463 putative active site [active] 448385011464 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385011465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011466 S-adenosylmethionine binding site [chemical binding]; other site 448385011467 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011468 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011469 active site 448385011470 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011471 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011472 putative NADP binding site [chemical binding]; other site 448385011473 active site 448385011474 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011475 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011476 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011477 active site 448385011478 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385011479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011480 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011481 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011482 putative NADP binding site [chemical binding]; other site 448385011483 active site 448385011484 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011485 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011486 active site 448385011487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011488 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385011489 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011490 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011491 putative NADP binding site [chemical binding]; other site 448385011492 active site 448385011493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011494 S-adenosylmethionine binding site [chemical binding]; other site 448385011495 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011496 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011497 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011498 active site 448385011499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011500 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 448385011501 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385011502 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011503 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011504 putative NADP binding site [chemical binding]; other site 448385011505 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011506 active site 448385011507 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011508 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011509 active site 448385011510 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011511 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011512 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011513 putative NADP binding site [chemical binding]; other site 448385011514 active site 448385011515 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385011516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011517 S-adenosylmethionine binding site [chemical binding]; other site 448385011518 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011519 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011520 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011521 active site 448385011522 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385011523 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011524 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011525 putative NADP binding site [chemical binding]; other site 448385011526 active site 448385011527 Methyltransferase domain; Region: Methyltransf_12; pfam08242 448385011528 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011529 Condensation domain; Region: Condensation; pfam00668 448385011530 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385011531 Nonribosomal peptide synthase; Region: NRPS; pfam08415 448385011532 Condensation domain; Region: Condensation; pfam00668 448385011533 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385011534 Nonribosomal peptide synthase; Region: NRPS; pfam08415 448385011535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385011536 acyl-activating enzyme (AAE) consensus motif; other site 448385011537 AMP binding site [chemical binding]; other site 448385011538 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011539 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011540 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 448385011541 putative FMN binding site [chemical binding]; other site 448385011542 NADPH bind site [chemical binding]; other site 448385011543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011544 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011545 active site 448385011546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011547 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011548 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011549 active site 448385011550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385011551 KR domain; Region: KR; pfam08659 448385011552 NAD(P) binding site [chemical binding]; other site 448385011553 active site 448385011554 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011555 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011556 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011557 active site 448385011558 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011559 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011560 active site 448385011561 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011562 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011563 putative NADP binding site [chemical binding]; other site 448385011564 active site 448385011565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011568 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011569 active site 448385011570 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385011571 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011572 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011573 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011574 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011575 putative NADP binding site [chemical binding]; other site 448385011576 active site 448385011577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011578 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011579 active site 448385011580 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011581 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011582 putative NADP binding site [chemical binding]; other site 448385011583 active site 448385011584 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011585 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011586 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011587 active site 448385011588 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011589 putative NADP binding site [chemical binding]; other site 448385011590 KR domain; Region: KR; pfam08659 448385011591 active site 448385011592 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011593 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011594 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385011595 active site 448385011596 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011597 putative NADP binding site [chemical binding]; other site 448385011598 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011599 active site 448385011600 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385011601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011602 S-adenosylmethionine binding site [chemical binding]; other site 448385011603 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011604 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011605 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011606 active site 448385011607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011608 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011609 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011610 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011611 active site 448385011612 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385011613 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 448385011614 Acyl transferase domain; Region: Acyl_transf_1; cl08282 448385011615 Acyl transferase domain; Region: Acyl_transf_1; cl08282 448385011616 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011617 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011618 putative NADP binding site [chemical binding]; other site 448385011619 active site 448385011620 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011621 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011622 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385011623 active site 448385011624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385011625 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011626 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011627 putative NADP binding site [chemical binding]; other site 448385011628 active site 448385011629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011630 S-adenosylmethionine binding site [chemical binding]; other site 448385011631 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011632 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385011633 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385011634 active site 448385011635 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 448385011636 putative NADP binding site [chemical binding]; other site 448385011637 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385011638 active site 448385011639 Methyltransferase domain; Region: Methyltransf_12; pfam08242 448385011640 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 448385011641 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 448385011642 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385011643 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 448385011644 FMN binding site [chemical binding]; other site 448385011645 substrate binding site [chemical binding]; other site 448385011646 putative catalytic residue [active] 448385011647 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385011648 putative active site [active] 448385011649 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 448385011650 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 448385011651 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385011652 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 448385011653 HmuY protein; Region: HmuY; pfam14064 448385011654 FOG: CBS domain [General function prediction only]; Region: COG0517 448385011655 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385011656 FOG: CBS domain [General function prediction only]; Region: COG0517 448385011657 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385011658 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 448385011659 conserved hypothetical protein; Region: TIGR02270 448385011660 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385011661 FAD binding domain; Region: FAD_binding_4; pfam01565 448385011662 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385011663 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385011664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385011665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385011666 putative substrate translocation pore; other site 448385011667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385011668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 448385011669 DNA binding site [nucleotide binding] 448385011670 domain linker motif; other site 448385011671 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385011672 dimerization interface [polypeptide binding]; other site 448385011673 ligand binding site [chemical binding]; other site 448385011674 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 448385011675 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 448385011676 ligand binding site [chemical binding]; other site 448385011677 NAD binding site [chemical binding]; other site 448385011678 tetramer interface [polypeptide binding]; other site 448385011679 catalytic site [active] 448385011680 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 448385011681 L-serine binding site [chemical binding]; other site 448385011682 ACT domain interface; other site 448385011683 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 448385011684 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385011685 active site 448385011686 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385011687 protein binding site [polypeptide binding]; other site 448385011688 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385011689 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385011690 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385011691 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385011692 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385011693 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385011694 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385011695 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385011696 phosphopeptide binding site; other site 448385011697 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385011698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385011699 Walker A motif; other site 448385011700 ATP binding site [chemical binding]; other site 448385011701 Walker B motif; other site 448385011702 arginine finger; other site 448385011703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 448385011704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385011705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385011706 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385011707 putative effector binding pocket; other site 448385011708 dimerization interface [polypeptide binding]; other site 448385011709 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385011710 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385011711 active site 448385011712 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 448385011713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 448385011714 Beta-Casp domain; Region: Beta-Casp; smart01027 448385011715 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 448385011716 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 448385011717 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 448385011718 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 448385011719 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 448385011720 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385011721 putative hydrophobic ligand binding site [chemical binding]; other site 448385011722 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385011723 dimerization interface [polypeptide binding]; other site 448385011724 putative DNA binding site [nucleotide binding]; other site 448385011725 putative Zn2+ binding site [ion binding]; other site 448385011726 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 448385011727 RibD C-terminal domain; Region: RibD_C; cl17279 448385011728 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 448385011729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011730 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011731 active site 448385011732 ATP binding site [chemical binding]; other site 448385011733 substrate binding site [chemical binding]; other site 448385011734 activation loop (A-loop); other site 448385011735 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011736 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011737 active site 448385011738 ATP binding site [chemical binding]; other site 448385011739 substrate binding site [chemical binding]; other site 448385011740 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385011741 substrate binding site [chemical binding]; other site 448385011742 activation loop (A-loop); other site 448385011743 activation loop (A-loop); other site 448385011744 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385011745 TPR motif; other site 448385011746 binding surface 448385011747 phosphoenolpyruvate synthase; Validated; Region: PRK06241 448385011748 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385011749 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385011750 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385011751 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011752 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011753 active site 448385011754 ATP binding site [chemical binding]; other site 448385011755 substrate binding site [chemical binding]; other site 448385011756 activation loop (A-loop); other site 448385011757 Merozoite surface antigen 2c; Region: MSA-2c; pfam12238 448385011758 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 448385011759 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385011760 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011761 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011762 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011763 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011764 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011766 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011767 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011768 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011769 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011770 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011771 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011772 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011773 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011774 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011775 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011776 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011777 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011778 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385011779 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 448385011780 CheB methylesterase; Region: CheB_methylest; pfam01339 448385011781 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 448385011782 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 448385011783 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 448385011784 PAS domain; Region: PAS_10; pfam13596 448385011785 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385011786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385011787 putative active site [active] 448385011788 heme pocket [chemical binding]; other site 448385011789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385011790 dimer interface [polypeptide binding]; other site 448385011791 phosphorylation site [posttranslational modification] 448385011792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385011793 ATP binding site [chemical binding]; other site 448385011794 Mg2+ binding site [ion binding]; other site 448385011795 G-X-G motif; other site 448385011796 Response regulator receiver domain; Region: Response_reg; pfam00072 448385011797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385011798 active site 448385011799 phosphorylation site [posttranslational modification] 448385011800 intermolecular recognition site; other site 448385011801 dimerization interface [polypeptide binding]; other site 448385011802 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 448385011803 PAS domain S-box; Region: sensory_box; TIGR00229 448385011804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385011805 putative active site [active] 448385011806 heme pocket [chemical binding]; other site 448385011807 PAS domain; Region: PAS; smart00091 448385011808 PAS fold; Region: PAS_4; pfam08448 448385011809 putative active site [active] 448385011810 heme pocket [chemical binding]; other site 448385011811 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385011812 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 448385011813 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 448385011814 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 448385011815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385011816 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385011817 FeS/SAM binding site; other site 448385011818 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 448385011819 beta-galactosidase; Region: BGL; TIGR03356 448385011820 TPR repeat; Region: TPR_11; pfam13414 448385011821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385011822 binding surface 448385011823 TPR motif; other site 448385011824 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 448385011825 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 448385011826 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 448385011827 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385011828 NAD binding site [chemical binding]; other site 448385011829 catalytic Zn binding site [ion binding]; other site 448385011830 structural Zn binding site [ion binding]; other site 448385011831 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 448385011832 Cation efflux family; Region: Cation_efflux; cl00316 448385011833 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 448385011834 active site 448385011835 substrate-binding site [chemical binding]; other site 448385011836 metal-binding site [ion binding] 448385011837 GTP binding site [chemical binding]; other site 448385011838 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385011839 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011840 active site 448385011841 ATP binding site [chemical binding]; other site 448385011842 substrate binding site [chemical binding]; other site 448385011843 activation loop (A-loop); other site 448385011844 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 448385011845 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385011846 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 448385011847 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 448385011848 substrate binding pocket [chemical binding]; other site 448385011849 chain length determination region; other site 448385011850 substrate-Mg2+ binding site; other site 448385011851 catalytic residues [active] 448385011852 aspartate-rich region 1; other site 448385011853 active site lid residues [active] 448385011854 aspartate-rich region 2; other site 448385011855 mevalonate kinase; Region: mevalon_kin; TIGR00549 448385011856 mevalonate kinase; Region: mevalon_kin; TIGR00549 448385011857 diphosphomevalonate decarboxylase; Region: PLN02407 448385011858 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 448385011859 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 448385011860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385011861 AAA domain; Region: AAA_23; pfam13476 448385011862 Walker A/P-loop; other site 448385011863 ATP binding site [chemical binding]; other site 448385011864 AAA domain; Region: AAA_21; pfam13304 448385011865 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385011866 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385011867 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385011868 RHS Repeat; Region: RHS_repeat; pfam05593 448385011869 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385011870 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385011871 RHS Repeat; Region: RHS_repeat; pfam05593 448385011872 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385011873 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 448385011874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385011875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385011876 homodimer interface [polypeptide binding]; other site 448385011877 catalytic residue [active] 448385011878 TPR repeat; Region: TPR_11; pfam13414 448385011879 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 448385011880 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385011881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385011882 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 448385011883 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385011884 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 448385011885 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 448385011886 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385011887 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 448385011888 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 448385011889 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 448385011890 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 448385011891 SLBB domain; Region: SLBB; pfam10531 448385011892 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 448385011893 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 448385011894 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 448385011895 putative dimer interface [polypeptide binding]; other site 448385011896 [2Fe-2S] cluster binding site [ion binding]; other site 448385011897 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 448385011898 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 448385011899 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 448385011900 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011901 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011902 active site 448385011903 ATP binding site [chemical binding]; other site 448385011904 substrate binding site [chemical binding]; other site 448385011905 activation loop (A-loop); other site 448385011906 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 448385011907 active site 448385011908 catalytic site [active] 448385011909 substrate binding site [chemical binding]; other site 448385011910 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 448385011911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385011912 motif II; other site 448385011913 Predicted ATPases [General function prediction only]; Region: COG1106 448385011914 Predicted ATPase [General function prediction only]; Region: COG4637 448385011915 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385011916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385011917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385011918 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385011919 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385011920 active site 448385011921 catalytic tetrad [active] 448385011922 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 448385011923 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385011924 active site 448385011925 HIGH motif; other site 448385011926 nucleotide binding site [chemical binding]; other site 448385011927 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385011928 active site 448385011929 KMSKS motif; other site 448385011930 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 448385011931 tRNA binding surface [nucleotide binding]; other site 448385011932 anticodon binding site; other site 448385011933 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 448385011934 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385011935 putative active site [active] 448385011936 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 448385011937 active site 448385011938 pyrophosphate binding site [ion binding]; other site 448385011939 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 448385011940 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385011941 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 448385011942 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385011943 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 448385011944 ThiS interaction site; other site 448385011945 putative active site [active] 448385011946 tetramer interface [polypeptide binding]; other site 448385011947 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385011948 active site 448385011949 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 448385011950 catalytic site [active] 448385011951 putative active site [active] 448385011952 putative substrate binding site [chemical binding]; other site 448385011953 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385011954 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385011955 biotin synthase; Region: bioB; TIGR00433 448385011956 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385011957 FeS/SAM binding site; other site 448385011958 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 448385011959 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 448385011960 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385011961 Walker A motif; other site 448385011962 ATP binding site [chemical binding]; other site 448385011963 Walker B motif; other site 448385011964 ThiC family; Region: ThiC; pfam01964 448385011965 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 448385011966 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385011967 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385011968 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385011969 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 448385011970 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385011971 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385011972 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385011973 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385011974 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385011975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385011976 S-adenosylmethionine binding site [chemical binding]; other site 448385011977 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385011978 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 448385011979 putative NAD(P) binding site [chemical binding]; other site 448385011980 active site 448385011981 putative substrate binding site [chemical binding]; other site 448385011982 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385011983 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 448385011984 putative acyl-acceptor binding pocket; other site 448385011985 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 448385011986 dimer interface [polypeptide binding]; other site 448385011987 catalytic triad [active] 448385011988 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385011989 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385011990 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385011991 active site 448385011992 ATP binding site [chemical binding]; other site 448385011993 substrate binding site [chemical binding]; other site 448385011994 activation loop (A-loop); other site 448385011995 TPR repeat; Region: TPR_11; pfam13414 448385011996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385011997 binding surface 448385011998 TPR motif; other site 448385011999 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385012000 dihydroorotase; Validated; Region: pyrC; PRK09357 448385012001 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 448385012002 active site 448385012003 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 448385012004 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 448385012005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385012006 FeS/SAM binding site; other site 448385012007 TRAM domain; Region: TRAM; cl01282 448385012008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385012009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385012010 active site 448385012011 phosphorylation site [posttranslational modification] 448385012012 intermolecular recognition site; other site 448385012013 dimerization interface [polypeptide binding]; other site 448385012014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012015 Walker A motif; other site 448385012016 ATP binding site [chemical binding]; other site 448385012017 Walker B motif; other site 448385012018 arginine finger; other site 448385012019 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385012020 PEGA domain; Region: PEGA; pfam08308 448385012021 PEGA domain; Region: PEGA; pfam08308 448385012022 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 448385012023 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385012024 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 448385012025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385012026 Coenzyme A binding pocket [chemical binding]; other site 448385012027 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 448385012028 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385012029 putative NAD(P) binding site [chemical binding]; other site 448385012030 active site 448385012031 putative substrate binding site [chemical binding]; other site 448385012032 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385012033 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 448385012034 putative acyl-acceptor binding pocket; other site 448385012035 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 448385012036 active site 448385012037 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 448385012038 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 448385012039 Domain of unknown function DUF21; Region: DUF21; pfam01595 448385012040 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 448385012041 Transporter associated domain; Region: CorC_HlyC; smart01091 448385012042 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385012043 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385012044 TAP-like protein; Region: Abhydrolase_4; pfam08386 448385012045 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 448385012046 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 448385012047 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 448385012048 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 448385012049 RNA binding site [nucleotide binding]; other site 448385012050 imidazolonepropionase; Validated; Region: PRK09356 448385012051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385012052 active site 448385012053 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 448385012054 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 448385012055 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 448385012056 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385012057 putative NAD(P) binding site [chemical binding]; other site 448385012058 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 448385012059 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 448385012060 Type II/IV secretion system protein; Region: T2SE; pfam00437 448385012061 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385012062 Walker A motif; other site 448385012063 ATP binding site [chemical binding]; other site 448385012064 Walker B motif; other site 448385012065 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 448385012066 beta-galactosidase; Region: BGL; TIGR03356 448385012067 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 448385012068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385012069 Walker A/P-loop; other site 448385012070 ATP binding site [chemical binding]; other site 448385012071 Q-loop/lid; other site 448385012072 ABC transporter signature motif; other site 448385012073 Walker B; other site 448385012074 D-loop; other site 448385012075 H-loop/switch region; other site 448385012076 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 448385012077 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 448385012078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385012079 Walker A/P-loop; other site 448385012080 ATP binding site [chemical binding]; other site 448385012081 Q-loop/lid; other site 448385012082 ABC transporter signature motif; other site 448385012083 Walker B; other site 448385012084 D-loop; other site 448385012085 H-loop/switch region; other site 448385012086 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 448385012087 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 448385012088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385012089 dimer interface [polypeptide binding]; other site 448385012090 conserved gate region; other site 448385012091 putative PBP binding loops; other site 448385012092 ABC-ATPase subunit interface; other site 448385012093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 448385012094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385012095 dimer interface [polypeptide binding]; other site 448385012096 conserved gate region; other site 448385012097 putative PBP binding loops; other site 448385012098 ABC-ATPase subunit interface; other site 448385012099 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 448385012100 substrate binding site [chemical binding]; other site 448385012101 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 448385012102 Right handed beta helix region; Region: Beta_helix; pfam13229 448385012103 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 448385012104 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 448385012105 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 448385012106 NAD(P) binding site [chemical binding]; other site 448385012107 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385012108 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385012109 phosphopeptide binding site; other site 448385012110 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385012111 metal binding site [ion binding]; metal-binding site 448385012112 active site 448385012113 I-site; other site 448385012114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012115 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385012116 Walker A motif; other site 448385012117 ATP binding site [chemical binding]; other site 448385012118 Walker B motif; other site 448385012119 arginine finger; other site 448385012120 Protein of unknown function (DUF962); Region: DUF962; pfam06127 448385012121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385012122 NAD(P) binding site [chemical binding]; other site 448385012123 active site 448385012124 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385012125 dimer interface [polypeptide binding]; other site 448385012126 phosphorylation site [posttranslational modification] 448385012127 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385012128 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385012129 dinuclear metal binding motif [ion binding]; other site 448385012130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385012131 active site 448385012132 motif I; other site 448385012133 motif II; other site 448385012134 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385012135 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 448385012136 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 448385012137 Permutation of conserved domain; other site 448385012138 active site 448385012139 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 448385012140 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385012141 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385012142 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385012143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385012144 ligand binding site [chemical binding]; other site 448385012145 flexible hinge region; other site 448385012146 amidophosphoribosyltransferase; Provisional; Region: PRK09123 448385012147 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 448385012148 active site 448385012149 tetramer interface [polypeptide binding]; other site 448385012150 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385012151 active site 448385012152 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 448385012153 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 448385012154 active site 448385012155 catalytic residues [active] 448385012156 metal binding site [ion binding]; metal-binding site 448385012157 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385012158 Lamin Tail Domain; Region: LTD; pfam00932 448385012159 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 448385012160 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 448385012161 active site 448385012162 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 448385012163 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 448385012164 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385012165 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385012166 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 448385012167 putative acyl-acceptor binding pocket; other site 448385012168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012170 active site 448385012171 ATP binding site [chemical binding]; other site 448385012172 substrate binding site [chemical binding]; other site 448385012173 activation loop (A-loop); other site 448385012174 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 448385012175 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 448385012176 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012177 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012178 active site 448385012179 ATP binding site [chemical binding]; other site 448385012180 substrate binding site [chemical binding]; other site 448385012181 activation loop (A-loop); other site 448385012182 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385012183 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012184 substrate binding site [chemical binding]; other site 448385012185 activation loop (A-loop); other site 448385012186 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012187 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 448385012188 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385012189 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385012190 ligand binding site [chemical binding]; other site 448385012191 flexible hinge region; other site 448385012192 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385012193 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385012194 ligand binding site [chemical binding]; other site 448385012195 flexible hinge region; other site 448385012196 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 448385012197 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 448385012198 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385012199 metal ion-dependent adhesion site (MIDAS); other site 448385012200 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012201 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012202 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012203 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012204 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 448385012205 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 448385012206 Ferredoxin [Energy production and conversion]; Region: COG1146 448385012207 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385012208 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385012209 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385012210 metal ion-dependent adhesion site (MIDAS); other site 448385012211 YceG-like family; Region: YceG; pfam02618 448385012212 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 448385012213 dimerization interface [polypeptide binding]; other site 448385012214 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 448385012215 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 448385012216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385012217 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385012218 Glucokinase; Region: Glucokinase; pfam02685 448385012219 glucokinase, proteobacterial type; Region: glk; TIGR00749 448385012220 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 448385012221 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 448385012222 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 448385012223 dimer interface [polypeptide binding]; other site 448385012224 motif 1; other site 448385012225 active site 448385012226 motif 2; other site 448385012227 motif 3; other site 448385012228 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 448385012229 anticodon binding site; other site 448385012230 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 448385012231 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 448385012232 putative active site [active] 448385012233 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 448385012234 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 448385012235 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 448385012236 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 448385012237 Protein of unknown function (DUF433); Region: DUF433; cl01030 448385012238 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012239 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012240 active site 448385012241 ATP binding site [chemical binding]; other site 448385012242 substrate binding site [chemical binding]; other site 448385012243 activation loop (A-loop); other site 448385012244 Predicted ATPase [General function prediction only]; Region: COG3899 448385012245 AAA ATPase domain; Region: AAA_16; pfam13191 448385012246 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385012247 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385012248 putative acyl-acceptor binding pocket; other site 448385012249 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385012250 putative active site [active] 448385012251 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 448385012252 A new structural DNA glycosylase; Region: AlkD_like; cd06561 448385012253 active site 448385012254 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 448385012255 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 448385012256 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385012257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385012258 ATP binding site [chemical binding]; other site 448385012259 putative Mg++ binding site [ion binding]; other site 448385012260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385012261 nucleotide binding region [chemical binding]; other site 448385012262 ATP-binding site [chemical binding]; other site 448385012263 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 448385012264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385012265 PAS domain; Region: PAS_9; pfam13426 448385012266 putative active site [active] 448385012267 heme pocket [chemical binding]; other site 448385012268 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385012269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385012270 putative active site [active] 448385012271 heme pocket [chemical binding]; other site 448385012272 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 448385012273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385012274 putative active site [active] 448385012275 heme pocket [chemical binding]; other site 448385012276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385012277 dimer interface [polypeptide binding]; other site 448385012278 phosphorylation site [posttranslational modification] 448385012279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385012280 ATP binding site [chemical binding]; other site 448385012281 Mg2+ binding site [ion binding]; other site 448385012282 G-X-G motif; other site 448385012283 Response regulator receiver domain; Region: Response_reg; pfam00072 448385012284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385012285 active site 448385012286 phosphorylation site [posttranslational modification] 448385012287 intermolecular recognition site; other site 448385012288 dimerization interface [polypeptide binding]; other site 448385012289 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 448385012290 active site residue [active] 448385012291 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012292 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012293 active site 448385012294 ATP binding site [chemical binding]; other site 448385012295 substrate binding site [chemical binding]; other site 448385012296 activation loop (A-loop); other site 448385012297 Domain of unknown function DUF87; Region: DUF87; pfam01935 448385012298 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 448385012299 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 448385012300 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 448385012301 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 448385012302 putative NADH binding site [chemical binding]; other site 448385012303 putative active site [active] 448385012304 nudix motif; other site 448385012305 putative metal binding site [ion binding]; other site 448385012306 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 448385012307 putative active site [active] 448385012308 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 448385012309 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385012310 Uncharacterized conserved protein [Function unknown]; Region: COG0327 448385012311 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 448385012312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 448385012313 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 448385012314 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 448385012315 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 448385012316 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 448385012317 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385012318 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385012319 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012320 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012321 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 448385012322 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 448385012323 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 448385012324 homodimer interface [polypeptide binding]; other site 448385012325 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 448385012326 active site pocket [active] 448385012327 Uncharacterized conserved protein [Function unknown]; Region: COG2127 448385012328 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 448385012329 Clp amino terminal domain; Region: Clp_N; pfam02861 448385012330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012331 Walker A motif; other site 448385012332 ATP binding site [chemical binding]; other site 448385012333 Walker B motif; other site 448385012334 arginine finger; other site 448385012335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012336 Walker A motif; other site 448385012337 ATP binding site [chemical binding]; other site 448385012338 Walker B motif; other site 448385012339 arginine finger; other site 448385012340 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385012341 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 448385012342 Rhomboid family; Region: Rhomboid; cl11446 448385012343 D-cysteine desulfhydrase; Validated; Region: PRK03910 448385012344 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 448385012345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385012346 catalytic residue [active] 448385012347 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385012348 dinuclear metal binding motif [ion binding]; other site 448385012349 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 448385012350 homodimer interface [polypeptide binding]; other site 448385012351 substrate-cofactor binding pocket; other site 448385012352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385012353 catalytic residue [active] 448385012354 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 448385012355 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385012356 putative di-iron ligands [ion binding]; other site 448385012357 agmatinase; Region: agmatinase; TIGR01230 448385012358 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 448385012359 putative active site [active] 448385012360 Mn binding site [ion binding]; other site 448385012361 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 448385012362 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 448385012363 active site 448385012364 metal binding site [ion binding]; metal-binding site 448385012365 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 448385012366 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 448385012367 quinone interaction residues [chemical binding]; other site 448385012368 active site 448385012369 catalytic residues [active] 448385012370 FMN binding site [chemical binding]; other site 448385012371 substrate binding site [chemical binding]; other site 448385012372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 448385012373 Protein of unknown function, DUF482; Region: DUF482; pfam04339 448385012374 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385012375 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385012376 phosphopeptide binding site; other site 448385012377 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385012378 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012379 Walker A motif; other site 448385012380 ATP binding site [chemical binding]; other site 448385012381 Walker B motif; other site 448385012382 arginine finger; other site 448385012383 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012384 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012385 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 448385012386 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 448385012387 Transglycosylase; Region: Transgly; pfam00912 448385012388 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 448385012389 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 448385012390 Bacterial Ig-like domain; Region: Big_5; pfam13205 448385012391 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 448385012392 MG2 domain; Region: A2M_N; pfam01835 448385012393 Alpha-2-macroglobulin family; Region: A2M; pfam00207 448385012394 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 448385012395 surface patch; other site 448385012396 thioester region; other site 448385012397 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 448385012398 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 448385012399 Protein of unknown function, DUF608; Region: DUF608; pfam04685 448385012400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385012401 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385012402 TM-ABC transporter signature motif; other site 448385012403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385012404 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385012405 TM-ABC transporter signature motif; other site 448385012406 Isochorismatase family; Region: Isochorismatase; pfam00857 448385012407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 448385012408 catalytic triad [active] 448385012409 conserved cis-peptide bond; other site 448385012410 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 448385012411 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385012412 Walker A/P-loop; other site 448385012413 ATP binding site [chemical binding]; other site 448385012414 Q-loop/lid; other site 448385012415 ABC transporter signature motif; other site 448385012416 Walker B; other site 448385012417 D-loop; other site 448385012418 H-loop/switch region; other site 448385012419 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385012420 Isochorismatase family; Region: Isochorismatase; pfam00857 448385012421 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 448385012422 catalytic triad [active] 448385012423 conserved cis-peptide bond; other site 448385012424 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 448385012425 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 448385012426 putative ligand binding site [chemical binding]; other site 448385012427 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 448385012428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 448385012429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385012430 Walker A/P-loop; other site 448385012431 ATP binding site [chemical binding]; other site 448385012432 Q-loop/lid; other site 448385012433 ABC transporter signature motif; other site 448385012434 Walker B; other site 448385012435 D-loop; other site 448385012436 H-loop/switch region; other site 448385012437 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 448385012438 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 448385012439 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 448385012440 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 448385012441 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385012442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012443 active site 448385012444 ATP binding site [chemical binding]; other site 448385012445 substrate binding site [chemical binding]; other site 448385012446 activation loop (A-loop); other site 448385012447 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 448385012448 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 448385012449 active site 448385012450 Int/Topo IB signature motif; other site 448385012451 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 448385012452 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 448385012453 Protein of unknown function DUF72; Region: DUF72; cl00777 448385012454 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 448385012455 putative acyl-acceptor binding pocket; other site 448385012456 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 448385012457 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 448385012458 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 448385012459 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 448385012460 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 448385012461 RimM N-terminal domain; Region: RimM; pfam01782 448385012462 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 448385012463 KH domain; Region: KH_4; pfam13083 448385012464 G-X-X-G motif; other site 448385012465 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 448385012466 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 448385012467 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385012468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012469 Walker A motif; other site 448385012470 ATP binding site [chemical binding]; other site 448385012471 Walker B motif; other site 448385012472 arginine finger; other site 448385012473 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 448385012474 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385012475 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 448385012476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385012477 S-adenosylmethionine binding site [chemical binding]; other site 448385012478 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 448385012479 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 448385012480 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 448385012481 alpha subunit interaction interface [polypeptide binding]; other site 448385012482 Walker A motif; other site 448385012483 ATP binding site [chemical binding]; other site 448385012484 Walker B motif; other site 448385012485 inhibitor binding site; inhibition site 448385012486 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 448385012487 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 448385012488 gamma subunit interface [polypeptide binding]; other site 448385012489 epsilon subunit interface [polypeptide binding]; other site 448385012490 LBP interface [polypeptide binding]; other site 448385012491 DNA primase; Validated; Region: dnaG; PRK05667 448385012492 CHC2 zinc finger; Region: zf-CHC2; pfam01807 448385012493 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 448385012494 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 448385012495 active site 448385012496 metal binding site [ion binding]; metal-binding site 448385012497 interdomain interaction site; other site 448385012498 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 448385012499 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 448385012500 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 448385012501 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385012502 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 448385012503 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385012504 DNA binding residues [nucleotide binding] 448385012505 Rhomboid family; Region: Rhomboid; cl11446 448385012506 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 448385012507 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385012508 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385012509 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385012510 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385012511 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 448385012512 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385012513 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 448385012514 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 448385012515 CAP-like domain; other site 448385012516 active site 448385012517 primary dimer interface [polypeptide binding]; other site 448385012518 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 448385012519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385012520 Mg2+ binding site [ion binding]; other site 448385012521 G-X-G motif; other site 448385012522 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 448385012523 anchoring element; other site 448385012524 dimer interface [polypeptide binding]; other site 448385012525 ATP binding site [chemical binding]; other site 448385012526 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 448385012527 active site 448385012528 putative metal-binding site [ion binding]; other site 448385012529 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 448385012530 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385012531 nitrilase; Region: PLN02798 448385012532 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 448385012533 putative active site [active] 448385012534 catalytic triad [active] 448385012535 dimer interface [polypeptide binding]; other site 448385012536 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 448385012537 nudix motif; other site 448385012538 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 448385012539 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 448385012540 nucleotide binding pocket [chemical binding]; other site 448385012541 K-X-D-G motif; other site 448385012542 catalytic site [active] 448385012543 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 448385012544 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 448385012545 Dimer interface [polypeptide binding]; other site 448385012546 BRCT sequence motif; other site 448385012547 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 448385012548 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 448385012549 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 448385012550 Glutamate binding site [chemical binding]; other site 448385012551 NAD binding site [chemical binding]; other site 448385012552 catalytic residues [active] 448385012553 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385012554 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 448385012555 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 448385012556 active site 448385012557 Zn binding site [ion binding]; other site 448385012558 Tetratricopeptide repeat; Region: TPR_1; pfam00515 448385012559 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012560 active site 448385012561 ATP binding site [chemical binding]; other site 448385012562 substrate binding site [chemical binding]; other site 448385012563 activation loop (A-loop); other site 448385012564 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385012565 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385012566 phosphopeptide binding site; other site 448385012567 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 448385012568 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385012569 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 448385012570 Walker A motif; other site 448385012571 ATP binding site [chemical binding]; other site 448385012572 Walker B motif; other site 448385012573 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 448385012574 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 448385012575 Walker A motif; other site 448385012576 ATP binding site [chemical binding]; other site 448385012577 Walker B motif; other site 448385012578 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 448385012579 LexA repressor; Validated; Region: PRK00215 448385012580 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 448385012581 Catalytic site [active] 448385012582 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 448385012583 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385012584 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385012585 ligand binding site [chemical binding]; other site 448385012586 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385012587 PilZ domain; Region: PilZ; cl01260 448385012588 aspartate aminotransferase; Provisional; Region: PRK05764 448385012589 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385012590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385012591 homodimer interface [polypeptide binding]; other site 448385012592 catalytic residue [active] 448385012593 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 448385012594 mce related protein; Region: MCE; pfam02470 448385012595 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 448385012596 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 448385012597 Walker A/P-loop; other site 448385012598 ATP binding site [chemical binding]; other site 448385012599 Q-loop/lid; other site 448385012600 ABC transporter signature motif; other site 448385012601 Walker B; other site 448385012602 D-loop; other site 448385012603 H-loop/switch region; other site 448385012604 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 448385012605 DHH family; Region: DHH; pfam01368 448385012606 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 448385012607 Protein export membrane protein; Region: SecD_SecF; pfam02355 448385012608 protein-export membrane protein SecD; Region: secD; TIGR01129 448385012609 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 448385012610 Preprotein translocase subunit; Region: YajC; cl00806 448385012611 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 448385012612 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 448385012613 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 448385012614 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 448385012615 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 448385012616 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012617 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012618 active site 448385012619 ATP binding site [chemical binding]; other site 448385012620 substrate binding site [chemical binding]; other site 448385012621 activation loop (A-loop); other site 448385012622 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 448385012623 hypothetical protein; Provisional; Region: PRK07208 448385012624 FMN-binding domain; Region: FMN_bind; pfam04205 448385012625 glycogen branching enzyme; Provisional; Region: PRK05402 448385012626 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 448385012627 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 448385012628 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 448385012629 active site 448385012630 catalytic site [active] 448385012631 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 448385012632 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 448385012633 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 448385012634 NAD(P) binding site [chemical binding]; other site 448385012635 catalytic residues [active] 448385012636 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 448385012637 active site 448385012638 Zn binding site [ion binding]; other site 448385012639 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385012640 AAA ATPase domain; Region: AAA_16; pfam13191 448385012641 CHAT domain; Region: CHAT; cl17868 448385012642 hypothetical protein; Provisional; Region: PRK07236 448385012643 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 448385012644 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 448385012645 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 448385012646 Found in ATP-dependent protease La (LON); Region: LON; smart00464 448385012647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012648 Walker A motif; other site 448385012649 ATP binding site [chemical binding]; other site 448385012650 Walker B motif; other site 448385012651 arginine finger; other site 448385012652 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385012653 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385012654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385012655 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385012656 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385012657 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 448385012658 C-terminal domain interface [polypeptide binding]; other site 448385012659 GSH binding site (G-site) [chemical binding]; other site 448385012660 dimer interface [polypeptide binding]; other site 448385012661 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385012662 dimer interface [polypeptide binding]; other site 448385012663 substrate binding pocket (H-site) [chemical binding]; other site 448385012664 N-terminal domain interface [polypeptide binding]; other site 448385012665 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 448385012666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385012667 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 448385012668 dimerization interface [polypeptide binding]; other site 448385012669 substrate binding pocket [chemical binding]; other site 448385012670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385012671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385012672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012673 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012674 active site 448385012675 ATP binding site [chemical binding]; other site 448385012676 substrate binding site [chemical binding]; other site 448385012677 activation loop (A-loop); other site 448385012678 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385012679 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 448385012680 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 448385012681 heme-binding residues [chemical binding]; other site 448385012682 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 448385012683 molybdopterin cofactor binding site; other site 448385012684 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 448385012685 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 448385012686 4Fe-4S binding domain; Region: Fer4; cl02805 448385012687 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 448385012688 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 448385012689 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 448385012690 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385012691 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 448385012692 Cu(I) binding site [ion binding]; other site 448385012693 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 448385012694 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 448385012695 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 448385012696 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 448385012697 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 448385012698 Subunit I/III interface [polypeptide binding]; other site 448385012699 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 448385012700 dinuclear metal binding motif [ion binding]; other site 448385012701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385012702 Coenzyme A binding pocket [chemical binding]; other site 448385012703 phytoene desaturase; Region: crtI_fam; TIGR02734 448385012704 Double zinc ribbon; Region: DZR; pfam12773 448385012705 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012706 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012707 active site 448385012708 ATP binding site [chemical binding]; other site 448385012709 substrate binding site [chemical binding]; other site 448385012710 activation loop (A-loop); other site 448385012711 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012712 Family of unknown function (DUF490); Region: DUF490; pfam04357 448385012713 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 448385012714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385012715 S-adenosylmethionine binding site [chemical binding]; other site 448385012716 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012717 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012718 active site 448385012719 ATP binding site [chemical binding]; other site 448385012720 substrate binding site [chemical binding]; other site 448385012721 activation loop (A-loop); other site 448385012722 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 448385012723 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 448385012724 domain interfaces; other site 448385012725 active site 448385012726 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 448385012727 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 448385012728 RNase E interface [polypeptide binding]; other site 448385012729 trimer interface [polypeptide binding]; other site 448385012730 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 448385012731 RNase E interface [polypeptide binding]; other site 448385012732 trimer interface [polypeptide binding]; other site 448385012733 active site 448385012734 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 448385012735 putative nucleic acid binding region [nucleotide binding]; other site 448385012736 G-X-X-G motif; other site 448385012737 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 448385012738 RNA binding site [nucleotide binding]; other site 448385012739 domain interface; other site 448385012740 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 448385012741 16S/18S rRNA binding site [nucleotide binding]; other site 448385012742 S13e-L30e interaction site [polypeptide binding]; other site 448385012743 25S rRNA binding site [nucleotide binding]; other site 448385012744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012746 active site 448385012747 ATP binding site [chemical binding]; other site 448385012748 substrate binding site [chemical binding]; other site 448385012749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012750 substrate binding site [chemical binding]; other site 448385012751 activation loop (A-loop); other site 448385012752 activation loop (A-loop); other site 448385012753 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 448385012754 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 448385012755 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 448385012756 dimer interface [polypeptide binding]; other site 448385012757 motif 1; other site 448385012758 active site 448385012759 motif 2; other site 448385012760 motif 3; other site 448385012761 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 448385012762 anticodon binding site; other site 448385012763 HCaRG protein; Region: HCaRG; pfam07258 448385012764 COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in...; Region: Commd; cl06336 448385012765 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 448385012766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385012767 putative active site [active] 448385012768 heme pocket [chemical binding]; other site 448385012769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385012770 dimer interface [polypeptide binding]; other site 448385012771 phosphorylation site [posttranslational modification] 448385012772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385012773 ATP binding site [chemical binding]; other site 448385012774 Mg2+ binding site [ion binding]; other site 448385012775 G-X-G motif; other site 448385012776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385012777 Response regulator receiver domain; Region: Response_reg; pfam00072 448385012778 active site 448385012779 phosphorylation site [posttranslational modification] 448385012780 intermolecular recognition site; other site 448385012781 dimerization interface [polypeptide binding]; other site 448385012782 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385012783 H+ Antiporter protein; Region: 2A0121; TIGR00900 448385012784 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012786 active site 448385012787 ATP binding site [chemical binding]; other site 448385012788 substrate binding site [chemical binding]; other site 448385012789 activation loop (A-loop); other site 448385012790 AAA ATPase domain; Region: AAA_16; pfam13191 448385012791 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385012792 structural tetrad; other site 448385012793 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385012794 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385012795 structural tetrad; other site 448385012796 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385012797 structural tetrad; other site 448385012798 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385012799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012801 active site 448385012802 ATP binding site [chemical binding]; other site 448385012803 substrate binding site [chemical binding]; other site 448385012804 activation loop (A-loop); other site 448385012805 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385012806 AAA ATPase domain; Region: AAA_16; pfam13191 448385012807 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385012808 WD40 repeats; Region: WD40; smart00320 448385012809 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385012810 structural tetrad; other site 448385012811 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385012812 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385012813 structural tetrad; other site 448385012814 WD40 repeats; Region: WD40; smart00320 448385012815 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385012816 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 448385012817 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385012818 ATP binding site [chemical binding]; other site 448385012819 putative Mg++ binding site [ion binding]; other site 448385012820 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385012821 nucleotide binding region [chemical binding]; other site 448385012822 ATP-binding site [chemical binding]; other site 448385012823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012824 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012825 active site 448385012826 ATP binding site [chemical binding]; other site 448385012827 substrate binding site [chemical binding]; other site 448385012828 activation loop (A-loop); other site 448385012829 Right handed beta helix region; Region: Beta_helix; pfam13229 448385012830 Right handed beta helix region; Region: Beta_helix; pfam13229 448385012831 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012832 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012833 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012834 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012835 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012836 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012837 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012838 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385012839 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012840 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012841 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385012842 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385012843 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385012844 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 448385012845 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385012846 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 448385012847 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385012848 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385012849 amino acid transporter; Region: 2A0306; TIGR00909 448385012850 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 448385012851 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 448385012852 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385012853 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 448385012854 Soluble P-type ATPase [General function prediction only]; Region: COG4087 448385012855 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 448385012856 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 448385012857 phosphoenolpyruvate synthase; Validated; Region: PRK06464 448385012858 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385012859 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 448385012860 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 448385012861 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 448385012862 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385012863 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385012864 ligand binding site [chemical binding]; other site 448385012865 flexible hinge region; other site 448385012866 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 448385012867 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 448385012868 FAD binding pocket [chemical binding]; other site 448385012869 FAD binding motif [chemical binding]; other site 448385012870 phosphate binding motif [ion binding]; other site 448385012871 beta-alpha-beta structure motif; other site 448385012872 NAD binding pocket [chemical binding]; other site 448385012873 Iron coordination center [ion binding]; other site 448385012874 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 448385012875 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 448385012876 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 448385012877 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 448385012878 nickel binding site [ion binding]; other site 448385012879 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 448385012880 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 448385012881 Acylphosphatase; Region: Acylphosphatase; pfam00708 448385012882 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 448385012883 HypF finger; Region: zf-HYPF; pfam07503 448385012884 HypF finger; Region: zf-HYPF; pfam07503 448385012885 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 448385012886 HupF/HypC family; Region: HupF_HypC; pfam01455 448385012887 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 448385012888 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 448385012889 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 448385012890 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 448385012891 dimerization interface [polypeptide binding]; other site 448385012892 ATP binding site [chemical binding]; other site 448385012893 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 448385012894 active site 448385012895 catalytic triad [active] 448385012896 oxyanion hole [active] 448385012897 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385012898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012900 active site 448385012901 ATP binding site [chemical binding]; other site 448385012902 substrate binding site [chemical binding]; other site 448385012903 activation loop (A-loop); other site 448385012904 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012905 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012906 active site 448385012907 ATP binding site [chemical binding]; other site 448385012908 substrate binding site [chemical binding]; other site 448385012909 activation loop (A-loop); other site 448385012910 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385012911 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385012912 phosphopeptide binding site; other site 448385012913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385012914 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385012915 Walker A motif; other site 448385012916 ATP binding site [chemical binding]; other site 448385012917 Walker B motif; other site 448385012918 arginine finger; other site 448385012919 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385012920 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385012921 putative sugar binding sites [chemical binding]; other site 448385012922 Q-X-W motif; other site 448385012923 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 448385012924 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385012925 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385012926 putative sugar binding sites [chemical binding]; other site 448385012927 Q-X-W motif; other site 448385012928 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 448385012929 active site 448385012930 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385012931 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385012932 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385012933 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012934 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012935 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385012936 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 448385012937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385012938 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 448385012939 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 448385012940 active site 448385012941 catalytic residues [active] 448385012942 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 448385012943 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 448385012944 substrate binding site [chemical binding]; other site 448385012945 active site 448385012946 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 448385012947 metal binding site [ion binding]; metal-binding site 448385012948 ligand binding site [chemical binding]; other site 448385012949 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 448385012950 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385012951 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385012952 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385012953 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012954 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012955 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385012956 Predicted peptidase [General function prediction only]; Region: COG4099 448385012957 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385012958 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385012959 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385012960 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385012961 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012962 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012963 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385012964 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385012965 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385012966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385012967 putative active site [active] 448385012968 heme pocket [chemical binding]; other site 448385012969 PAS domain; Region: PAS; smart00091 448385012970 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385012971 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385012972 oxyanion hole [active] 448385012973 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385012974 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385012975 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385012976 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385012977 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385012978 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385012979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012981 active site 448385012982 ATP binding site [chemical binding]; other site 448385012983 substrate binding site [chemical binding]; other site 448385012984 activation loop (A-loop); other site 448385012985 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012986 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012987 active site 448385012988 ATP binding site [chemical binding]; other site 448385012989 substrate binding site [chemical binding]; other site 448385012990 activation loop (A-loop); other site 448385012991 AAA ATPase domain; Region: AAA_16; pfam13191 448385012992 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385012993 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385012994 active site 448385012995 ATP binding site [chemical binding]; other site 448385012996 substrate binding site [chemical binding]; other site 448385012997 activation loop (A-loop); other site 448385012998 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 448385012999 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385013000 catalytic triad [active] 448385013001 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 448385013002 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385013003 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 448385013004 conserved cys residue [active] 448385013005 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385013006 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385013007 ligand binding site [chemical binding]; other site 448385013008 flexible hinge region; other site 448385013009 mechanosensitive channel MscS; Provisional; Region: PRK10334 448385013010 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385013011 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 448385013012 SnoaL-like domain; Region: SnoaL_3; pfam13474 448385013013 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 448385013014 active site 448385013015 HTH domain; Region: HTH_11; pfam08279 448385013016 WYL domain; Region: WYL; pfam13280 448385013017 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 448385013018 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 448385013019 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 448385013020 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 448385013021 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 448385013022 PA/protease or protease-like domain interface [polypeptide binding]; other site 448385013023 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 448385013024 Zn binding site [ion binding]; other site 448385013025 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 448385013026 active site clefts [active] 448385013027 zinc binding site [ion binding]; other site 448385013028 dimer interface [polypeptide binding]; other site 448385013029 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385013030 Cytochrome P450; Region: p450; cl12078 448385013031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013032 putative active site [active] 448385013033 heme pocket [chemical binding]; other site 448385013034 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013035 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385013036 Cytochrome P450; Region: p450; cl12078 448385013037 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 448385013038 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 448385013039 HPP family; Region: HPP; pfam04982 448385013040 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 448385013041 trimer interface [polypeptide binding]; other site 448385013042 active site 448385013043 substrate binding site [chemical binding]; other site 448385013044 CoA binding site [chemical binding]; other site 448385013045 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385013046 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385013047 dimer interface [polypeptide binding]; other site 448385013048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385013049 catalytic residue [active] 448385013050 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 448385013051 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385013052 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 448385013053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385013054 catalytic residue [active] 448385013055 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 448385013056 active site residue [active] 448385013057 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 448385013058 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385013059 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 448385013060 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 448385013061 putative deacylase active site [active] 448385013062 Integrase core domain; Region: rve_3; cl15866 448385013063 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 448385013064 active site 448385013065 nucleophile elbow; other site 448385013066 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 448385013067 H+ Antiporter protein; Region: 2A0121; TIGR00900 448385013068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385013069 putative substrate translocation pore; other site 448385013070 short chain dehydrogenase; Provisional; Region: PRK06172 448385013071 classical (c) SDRs; Region: SDR_c; cd05233 448385013072 NAD(P) binding site [chemical binding]; other site 448385013073 active site 448385013074 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385013075 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 448385013076 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385013077 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385013078 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385013079 Sporozoite P67 surface antigen; Region: Sporozoite_P67; pfam05642 448385013080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385013081 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385013082 phosphopeptide binding site; other site 448385013083 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 448385013084 Uncharacterized conserved protein [Function unknown]; Region: COG4104 448385013085 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385013086 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385013087 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385013088 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 448385013089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013091 active site 448385013092 ATP binding site [chemical binding]; other site 448385013093 substrate binding site [chemical binding]; other site 448385013094 activation loop (A-loop); other site 448385013095 AAA ATPase domain; Region: AAA_16; pfam13191 448385013096 hypothetical protein; Provisional; Region: PRK06194 448385013097 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 448385013098 putative NAD(P) binding site [chemical binding]; other site 448385013099 homotetramer interface [polypeptide binding]; other site 448385013100 active site 448385013101 homodimer interface [polypeptide binding]; other site 448385013102 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385013103 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013104 active site 448385013105 ATP binding site [chemical binding]; other site 448385013106 substrate binding site [chemical binding]; other site 448385013107 activation loop (A-loop); other site 448385013108 Predicted ATPase [General function prediction only]; Region: COG3899 448385013109 AAA ATPase domain; Region: AAA_16; pfam13191 448385013110 Domain of unknown function DUF11; Region: DUF11; cl17728 448385013111 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385013112 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385013113 active site 448385013114 catalytic residues [active] 448385013115 CHAT domain; Region: CHAT; pfam12770 448385013116 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385013117 GAF domain; Region: GAF_3; pfam13492 448385013118 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385013119 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 448385013120 ligand binding site [chemical binding]; other site 448385013121 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013122 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 448385013123 active site 448385013124 acceptor-phosphate pocket; other site 448385013125 polyP binding site; other site 448385013126 substrate binding site [chemical binding]; other site 448385013127 dimer interface [polypeptide binding]; other site 448385013128 putative metal binding residues [ion binding]; other site 448385013129 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385013130 active site 448385013131 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385013132 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084 448385013133 putative catalytic site [active] 448385013134 putative metal binding site [ion binding]; other site 448385013135 putative phosphate binding site [ion binding]; other site 448385013136 Protein of unknown function (DUF419); Region: DUF419; pfam04237 448385013137 mannose-6-phosphate isomerase; Region: PLN02288 448385013138 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 448385013139 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 448385013140 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 448385013141 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 448385013142 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 448385013143 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 448385013144 [4Fe-4S] binding site [ion binding]; other site 448385013145 molybdopterin cofactor binding site; other site 448385013146 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 448385013147 molybdopterin cofactor binding site; other site 448385013148 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 448385013149 4Fe-4S binding domain; Region: Fer4; pfam00037 448385013150 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 448385013151 Carboxylesterase family; Region: COesterase; pfam00135 448385013152 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 448385013153 substrate binding pocket [chemical binding]; other site 448385013154 catalytic triad [active] 448385013155 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 448385013156 putative active site [active] 448385013157 putative CoA binding site [chemical binding]; other site 448385013158 nudix motif; other site 448385013159 metal binding site [ion binding]; metal-binding site 448385013160 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 448385013161 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385013162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385013163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385013164 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 448385013165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013166 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385013167 Walker A motif; other site 448385013168 ATP binding site [chemical binding]; other site 448385013169 Walker B motif; other site 448385013170 arginine finger; other site 448385013171 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 448385013172 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385013173 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385013174 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385013175 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 448385013176 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 448385013177 Na binding site [ion binding]; other site 448385013178 putative substrate binding site [chemical binding]; other site 448385013179 PAS domain S-box; Region: sensory_box; TIGR00229 448385013180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013181 putative active site [active] 448385013182 heme pocket [chemical binding]; other site 448385013183 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385013185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385013186 active site 448385013187 catalytic tetrad [active] 448385013188 DoxX-like family; Region: DoxX_2; pfam13564 448385013189 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 448385013190 EF-hand domain pair; Region: EF_hand_5; pfam13499 448385013191 Ca2+ binding site [ion binding]; other site 448385013192 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 448385013193 Ca2+ binding site [ion binding]; other site 448385013194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 448385013195 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 448385013196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 448385013197 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385013198 RHS Repeat; Region: RHS_repeat; pfam05593 448385013199 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385013200 RHS Repeat; Region: RHS_repeat; pfam05593 448385013201 RHS Repeat; Region: RHS_repeat; pfam05593 448385013202 RHS Repeat; Region: RHS_repeat; cl11982 448385013203 RHS Repeat; Region: RHS_repeat; cl11982 448385013204 RHS Repeat; Region: RHS_repeat; pfam05593 448385013205 RHS Repeat; Region: RHS_repeat; pfam05593 448385013206 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385013207 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 448385013208 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385013209 minor groove reading motif; other site 448385013210 helix-hairpin-helix signature motif; other site 448385013211 substrate binding pocket [chemical binding]; other site 448385013212 active site 448385013213 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 448385013214 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 448385013215 ligand binding site [chemical binding]; other site 448385013216 active site 448385013217 UGI interface [polypeptide binding]; other site 448385013218 catalytic site [active] 448385013219 Flagellin N-methylase; Region: FliB; pfam03692 448385013220 glutathione S-transferase; Region: PLN02395 448385013221 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 448385013222 C-terminal domain interface [polypeptide binding]; other site 448385013223 GSH binding site (G-site) [chemical binding]; other site 448385013224 dimer interface [polypeptide binding]; other site 448385013225 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385013226 N-terminal domain interface [polypeptide binding]; other site 448385013227 dimer interface [polypeptide binding]; other site 448385013228 substrate binding pocket (H-site) [chemical binding]; other site 448385013229 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385013230 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385013231 phosphopeptide binding site; other site 448385013232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013233 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385013234 Walker A motif; other site 448385013235 ATP binding site [chemical binding]; other site 448385013236 Walker B motif; other site 448385013237 arginine finger; other site 448385013238 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385013239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013241 active site 448385013242 ATP binding site [chemical binding]; other site 448385013243 substrate binding site [chemical binding]; other site 448385013244 activation loop (A-loop); other site 448385013245 Phosphotransferase enzyme family; Region: APH; pfam01636 448385013246 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385013247 active site 448385013248 substrate binding site [chemical binding]; other site 448385013249 ATP binding site [chemical binding]; other site 448385013250 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 448385013251 active site 448385013252 Chitin binding domain; Region: Chitin_bind_3; cl03871 448385013253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385013254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385013255 active site 448385013256 catalytic tetrad [active] 448385013257 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385013258 catalytic residues [active] 448385013259 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 448385013260 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385013261 OPT oligopeptide transporter protein; Region: OPT; pfam03169 448385013262 putative oligopeptide transporter, OPT family; Region: TIGR00733 448385013263 Isochorismatase family; Region: Isochorismatase; pfam00857 448385013264 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 448385013265 catalytic triad [active] 448385013266 conserved cis-peptide bond; other site 448385013267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385013268 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385013269 putative effector binding pocket; other site 448385013270 dimerization interface [polypeptide binding]; other site 448385013271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013272 PAS domain; Region: PAS_9; pfam13426 448385013273 putative active site [active] 448385013274 heme pocket [chemical binding]; other site 448385013275 PAS domain S-box; Region: sensory_box; TIGR00229 448385013276 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013277 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385013278 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385013279 Walker A/P-loop; other site 448385013280 ATP binding site [chemical binding]; other site 448385013281 Q-loop/lid; other site 448385013282 ABC transporter signature motif; other site 448385013283 Walker B; other site 448385013284 D-loop; other site 448385013285 H-loop/switch region; other site 448385013286 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385013287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385013288 dimer interface [polypeptide binding]; other site 448385013289 conserved gate region; other site 448385013290 putative PBP binding loops; other site 448385013291 ABC-ATPase subunit interface; other site 448385013292 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385013293 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385013294 active site 448385013295 catalytic tetrad [active] 448385013296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385013297 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385013298 active site 448385013299 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385013300 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 448385013301 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385013302 catalytic residue [active] 448385013303 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013305 active site 448385013306 ATP binding site [chemical binding]; other site 448385013307 substrate binding site [chemical binding]; other site 448385013308 activation loop (A-loop); other site 448385013309 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385013310 Sel1-like repeats; Region: SEL1; smart00671 448385013311 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 448385013312 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 448385013313 active site 448385013314 Substrate binding site; other site 448385013315 Mg++ binding site; other site 448385013316 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 448385013317 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 448385013318 inhibitor-cofactor binding pocket; inhibition site 448385013319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385013320 catalytic residue [active] 448385013321 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 448385013322 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 448385013323 NAD binding site [chemical binding]; other site 448385013324 substrate binding site [chemical binding]; other site 448385013325 active site 448385013326 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385013327 putative catalytic site [active] 448385013328 putative metal binding site [ion binding]; other site 448385013329 putative phosphate binding site [ion binding]; other site 448385013330 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385013331 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385013332 dimer interface [polypeptide binding]; other site 448385013333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385013334 catalytic residue [active] 448385013335 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385013336 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 448385013337 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385013338 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 448385013339 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 448385013340 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 448385013341 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 448385013342 Sulfate transporter family; Region: Sulfate_transp; pfam00916 448385013343 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385013344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385013346 DNA binding residues [nucleotide binding] 448385013347 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385013348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013349 Walker A motif; other site 448385013350 ATP binding site [chemical binding]; other site 448385013351 Walker B motif; other site 448385013352 arginine finger; other site 448385013353 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 448385013354 active site 448385013355 substrate-binding site [chemical binding]; other site 448385013356 metal-binding site [ion binding] 448385013357 GTP binding site [chemical binding]; other site 448385013358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385013359 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 448385013360 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 448385013361 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 448385013362 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 448385013363 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385013364 NADH dehydrogenase; Region: NADHdh; cl00469 448385013365 hydrogenase 4 subunit B; Validated; Region: PRK06521 448385013366 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385013367 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 448385013368 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 448385013369 homodimer interface [polypeptide binding]; other site 448385013370 metal binding site [ion binding]; metal-binding site 448385013371 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 448385013372 homodimer interface [polypeptide binding]; other site 448385013373 active site 448385013374 putative chemical substrate binding site [chemical binding]; other site 448385013375 metal binding site [ion binding]; metal-binding site 448385013376 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385013377 Cytochrome P450; Region: p450; cl12078 448385013378 hypothetical protein; Provisional; Region: PRK07538 448385013379 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385013380 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385013381 dinuclear metal binding motif [ion binding]; other site 448385013382 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385013383 phosphopeptide binding site; other site 448385013384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385013385 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385013386 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385013387 Amb_all domain; Region: Amb_all; smart00656 448385013388 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 448385013389 putative metal binding site [ion binding]; other site 448385013390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 448385013391 classical (c) SDRs; Region: SDR_c; cd05233 448385013392 NAD(P) binding site [chemical binding]; other site 448385013393 active site 448385013394 PAS fold; Region: PAS_4; pfam08448 448385013395 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013396 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 448385013397 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385013398 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385013399 FtsX-like permease family; Region: FtsX; pfam02687 448385013400 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385013401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385013402 Walker A/P-loop; other site 448385013403 ATP binding site [chemical binding]; other site 448385013404 Q-loop/lid; other site 448385013405 ABC transporter signature motif; other site 448385013406 Walker B; other site 448385013407 D-loop; other site 448385013408 H-loop/switch region; other site 448385013409 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385013410 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 448385013411 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385013412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385013413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385013414 active site 448385013415 phosphorylation site [posttranslational modification] 448385013416 intermolecular recognition site; other site 448385013417 dimerization interface [polypeptide binding]; other site 448385013418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385013419 DNA binding site [nucleotide binding] 448385013420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385013421 dimerization interface [polypeptide binding]; other site 448385013422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385013423 dimer interface [polypeptide binding]; other site 448385013424 phosphorylation site [posttranslational modification] 448385013425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385013426 ATP binding site [chemical binding]; other site 448385013427 Mg2+ binding site [ion binding]; other site 448385013428 G-X-G motif; other site 448385013429 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 448385013430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013431 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013432 active site 448385013433 ATP binding site [chemical binding]; other site 448385013434 substrate binding site [chemical binding]; other site 448385013435 activation loop (A-loop); other site 448385013436 AAA ATPase domain; Region: AAA_16; pfam13191 448385013437 Protein kinase domain; Region: Pkinase; pfam00069 448385013438 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013439 active site 448385013440 substrate binding site [chemical binding]; other site 448385013441 ATP binding site [chemical binding]; other site 448385013442 activation loop (A-loop); other site 448385013443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385013444 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385013445 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 448385013446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385013447 FeS/SAM binding site; other site 448385013448 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 448385013449 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385013450 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385013451 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 448385013452 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 448385013453 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 448385013454 active site 448385013455 substrate binding site [chemical binding]; other site 448385013456 metal binding site [ion binding]; metal-binding site 448385013457 Chlorite dismutase; Region: Chlor_dismutase; cl01280 448385013458 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 448385013459 Response regulator receiver domain; Region: Response_reg; pfam00072 448385013460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385013461 active site 448385013462 phosphorylation site [posttranslational modification] 448385013463 intermolecular recognition site; other site 448385013464 dimerization interface [polypeptide binding]; other site 448385013465 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 448385013466 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 448385013467 active site 448385013468 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 448385013469 active site 448385013470 dimer interface [polypeptide binding]; other site 448385013471 metal binding site [ion binding]; metal-binding site 448385013472 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 448385013473 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 448385013474 Tetramer interface [polypeptide binding]; other site 448385013475 active site 448385013476 FMN-binding site [chemical binding]; other site 448385013477 glutamate racemase; Provisional; Region: PRK00865 448385013478 homoserine dehydrogenase; Provisional; Region: PRK06349 448385013479 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 448385013480 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 448385013481 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 448385013482 Protein of unknown function (DUF770); Region: DUF770; cl01402 448385013483 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 448385013484 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 448385013485 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 448385013486 dimerization interface [polypeptide binding]; other site 448385013487 active site 448385013488 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 448385013489 active site 448385013490 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 448385013491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385013492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385013493 WHG domain; Region: WHG; pfam13305 448385013494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385013495 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385013496 active site 448385013497 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385013498 active site 448385013499 ATP binding site [chemical binding]; other site 448385013500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385013501 S-adenosylmethionine binding site [chemical binding]; other site 448385013502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 448385013503 SnoaL-like domain; Region: SnoaL_2; pfam12680 448385013504 MAPEG family; Region: MAPEG; cl09190 448385013505 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385013506 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 448385013507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385013508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385013509 CotH protein; Region: CotH; pfam08757 448385013510 FecR protein; Region: FecR; pfam04773 448385013511 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385013512 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385013514 DNA binding residues [nucleotide binding] 448385013515 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 448385013516 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385013517 DXD motif; other site 448385013518 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 448385013519 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 448385013520 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 448385013521 substrate binding site; other site 448385013522 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 448385013523 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 448385013524 NAD binding site [chemical binding]; other site 448385013525 homotetramer interface [polypeptide binding]; other site 448385013526 homodimer interface [polypeptide binding]; other site 448385013527 substrate binding site [chemical binding]; other site 448385013528 active site 448385013529 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385013530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385013531 NAD(P) binding site [chemical binding]; other site 448385013532 active site 448385013533 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 448385013534 Kelch domain; Region: Kelch; smart00612 448385013535 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 448385013536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385013537 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385013538 active site 448385013539 metal binding site [ion binding]; metal-binding site 448385013540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385013541 Walker A/P-loop; other site 448385013542 ATP binding site [chemical binding]; other site 448385013543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385013544 Q-loop/lid; other site 448385013545 AAA domain; Region: AAA_21; pfam13304 448385013546 ABC transporter signature motif; other site 448385013547 Walker B; other site 448385013548 D-loop; other site 448385013549 H-loop/switch region; other site 448385013550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385013551 dimerization interface [polypeptide binding]; other site 448385013552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385013553 dimer interface [polypeptide binding]; other site 448385013554 phosphorylation site [posttranslational modification] 448385013555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385013556 ATP binding site [chemical binding]; other site 448385013557 Mg2+ binding site [ion binding]; other site 448385013558 G-X-G motif; other site 448385013559 DNA-binding response regulator CreB; Provisional; Region: PRK11083 448385013560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385013561 active site 448385013562 phosphorylation site [posttranslational modification] 448385013563 intermolecular recognition site; other site 448385013564 dimerization interface [polypeptide binding]; other site 448385013565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385013566 DNA binding site [nucleotide binding] 448385013567 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 448385013568 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 448385013569 2-isopropylmalate synthase; Validated; Region: PRK03739 448385013570 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 448385013571 active site 448385013572 catalytic residues [active] 448385013573 metal binding site [ion binding]; metal-binding site 448385013574 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 448385013575 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 448385013576 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 448385013577 inhibitor binding site; inhibition site 448385013578 active site 448385013579 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385013580 Cytochrome P450; Region: p450; pfam00067 448385013581 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 448385013582 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 448385013583 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 448385013584 putative NAD(P) binding site [chemical binding]; other site 448385013585 active site 448385013586 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 448385013587 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 448385013588 active site 448385013589 Acyl transferase domain; Region: Acyl_transf_1; cl08282 448385013590 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385013591 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 448385013592 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385013593 active site 448385013594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385013595 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385013596 NAD(P) binding site [chemical binding]; other site 448385013597 active site 448385013598 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 448385013599 MarR family; Region: MarR_2; cl17246 448385013600 Transcriptional regulators [Transcription]; Region: MarR; COG1846 448385013601 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 448385013602 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385013603 DNA binding residues [nucleotide binding] 448385013604 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013605 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013606 active site 448385013607 ATP binding site [chemical binding]; other site 448385013608 substrate binding site [chemical binding]; other site 448385013609 activation loop (A-loop); other site 448385013610 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 448385013611 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 448385013612 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 448385013613 dimer interface [polypeptide binding]; other site 448385013614 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 448385013615 active site 448385013616 Fe binding site [ion binding]; other site 448385013617 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 448385013618 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385013619 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 448385013620 hypothetical protein; Provisional; Region: PRK07538 448385013621 hypothetical protein; Provisional; Region: PRK07236 448385013622 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 448385013623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385013624 PAS fold; Region: PAS_4; pfam08448 448385013625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013626 putative active site [active] 448385013627 heme pocket [chemical binding]; other site 448385013628 PAS fold; Region: PAS_7; pfam12860 448385013629 PAS fold; Region: PAS_4; pfam08448 448385013630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013631 putative active site [active] 448385013632 heme pocket [chemical binding]; other site 448385013633 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385013634 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 448385013635 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 448385013636 putative NAD(P) binding site [chemical binding]; other site 448385013637 putative substrate binding site [chemical binding]; other site 448385013638 catalytic Zn binding site [ion binding]; other site 448385013639 structural Zn binding site [ion binding]; other site 448385013640 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385013641 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013642 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385013643 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385013644 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385013645 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385013646 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385013647 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385013648 Pectate lyase; Region: Pec_lyase_C; cl01593 448385013649 FecR protein; Region: FecR; pfam04773 448385013650 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385013651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385013653 DNA binding residues [nucleotide binding] 448385013654 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 448385013655 Pectate lyase; Region: Pec_lyase_C; cl01593 448385013656 GAF domain; Region: GAF; pfam01590 448385013657 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385013658 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 448385013659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385013660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385013661 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 448385013662 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 448385013663 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 448385013664 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 448385013665 urea carboxylase; Region: urea_carbox; TIGR02712 448385013666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385013667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385013668 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 448385013669 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 448385013670 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 448385013671 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 448385013672 carboxyltransferase (CT) interaction site; other site 448385013673 biotinylation site [posttranslational modification]; other site 448385013674 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 448385013675 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 448385013676 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 448385013677 active site 448385013678 dimer interface [polypeptide binding]; other site 448385013679 non-prolyl cis peptide bond; other site 448385013680 insertion regions; other site 448385013681 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 448385013682 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 448385013683 substrate binding pocket [chemical binding]; other site 448385013684 membrane-bound complex binding site; other site 448385013685 hinge residues; other site 448385013686 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 448385013687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385013688 dimer interface [polypeptide binding]; other site 448385013689 conserved gate region; other site 448385013690 putative PBP binding loops; other site 448385013691 ABC-ATPase subunit interface; other site 448385013692 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385013693 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385013694 Walker A/P-loop; other site 448385013695 ATP binding site [chemical binding]; other site 448385013696 Q-loop/lid; other site 448385013697 ABC transporter signature motif; other site 448385013698 Walker B; other site 448385013699 D-loop; other site 448385013700 H-loop/switch region; other site 448385013701 hypothetical protein; Validated; Region: PRK06186 448385013702 conserved cys residue [active] 448385013703 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385013704 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385013705 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385013706 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385013707 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013708 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013709 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013710 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385013711 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385013712 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013713 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385013714 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013715 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013717 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385013718 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385013719 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385013720 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385013721 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 448385013722 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 448385013723 substrate binding site [chemical binding]; other site 448385013724 Pectate lyase; Region: Pectate_lyase; pfam03211 448385013725 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 448385013726 active site 448385013727 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 448385013728 dimer interface [polypeptide binding]; other site 448385013729 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 448385013730 Ligand Binding Site [chemical binding]; other site 448385013731 Molecular Tunnel; other site 448385013732 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 448385013733 Interdomain contacts; other site 448385013734 Cytokine receptor motif; other site 448385013735 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385013736 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385013737 active site 448385013738 metal binding site [ion binding]; metal-binding site 448385013739 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 448385013740 Cytochrome c; Region: Cytochrom_C; pfam00034 448385013741 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 448385013742 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 448385013743 putative FMN binding site [chemical binding]; other site 448385013744 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 448385013745 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 448385013746 putative dimer interface [polypeptide binding]; other site 448385013747 active site pocket [active] 448385013748 putative cataytic base [active] 448385013749 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 448385013750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 448385013751 Uncharacterized conserved protein [Function unknown]; Region: COG4278 448385013752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385013753 AMP binding site [chemical binding]; other site 448385013754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385013755 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013756 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013757 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013758 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013759 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013760 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013761 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013762 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013763 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013764 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013765 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013766 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013767 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013768 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385013769 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013770 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013771 PA14 domain; Region: PA14; cl08459 448385013772 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385013773 PEGA domain; Region: PEGA; pfam08308 448385013774 PEGA domain; Region: PEGA; pfam08308 448385013775 Family description; Region: VCBS; pfam13517 448385013776 Family description; Region: VCBS; pfam13517 448385013777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385013778 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013779 active site 448385013780 ATP binding site [chemical binding]; other site 448385013781 substrate binding site [chemical binding]; other site 448385013782 activation loop (A-loop); other site 448385013783 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 448385013784 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 448385013785 putative dimer interface [polypeptide binding]; other site 448385013786 Response regulator receiver domain; Region: Response_reg; pfam00072 448385013787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385013788 active site 448385013789 phosphorylation site [posttranslational modification] 448385013790 intermolecular recognition site; other site 448385013791 dimerization interface [polypeptide binding]; other site 448385013792 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385013793 dimer interface [polypeptide binding]; other site 448385013794 phosphorylation site [posttranslational modification] 448385013795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385013796 ATP binding site [chemical binding]; other site 448385013797 G-X-G motif; other site 448385013798 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 448385013799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385013800 putative active site [active] 448385013801 heme pocket [chemical binding]; other site 448385013802 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385013803 dimer interface [polypeptide binding]; other site 448385013804 phosphorylation site [posttranslational modification] 448385013805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385013806 ATP binding site [chemical binding]; other site 448385013807 Mg2+ binding site [ion binding]; other site 448385013808 G-X-G motif; other site 448385013809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385013810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385013811 active site 448385013812 phosphorylation site [posttranslational modification] 448385013813 intermolecular recognition site; other site 448385013814 dimerization interface [polypeptide binding]; other site 448385013815 Phosphotransferase enzyme family; Region: APH; pfam01636 448385013816 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 448385013817 active site 448385013818 ATP binding site [chemical binding]; other site 448385013819 substrate binding site [chemical binding]; other site 448385013820 active site 448385013821 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 448385013822 Protein of unknown function (DUF796); Region: DUF796; cl01226 448385013823 PAS domain; Region: PAS; smart00091 448385013824 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 448385013825 glutathionine S-transferase; Provisional; Region: PRK10542 448385013826 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 448385013827 C-terminal domain interface [polypeptide binding]; other site 448385013828 GSH binding site (G-site) [chemical binding]; other site 448385013829 dimer interface [polypeptide binding]; other site 448385013830 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 448385013831 dimer interface [polypeptide binding]; other site 448385013832 N-terminal domain interface [polypeptide binding]; other site 448385013833 substrate binding pocket (H-site) [chemical binding]; other site 448385013834 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385013835 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385013836 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385013837 dimerization interface [polypeptide binding]; other site 448385013838 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 448385013839 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 448385013840 RNA polymerase sigma factor; Provisional; Region: PRK11924 448385013841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385013843 DNA binding residues [nucleotide binding] 448385013844 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 448385013845 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 448385013846 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 448385013847 metal binding site [ion binding]; metal-binding site 448385013848 dimer interface [polypeptide binding]; other site 448385013849 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 448385013850 apolar tunnel; other site 448385013851 heme binding site [chemical binding]; other site 448385013852 dimerization interface [polypeptide binding]; other site 448385013853 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385013854 hypothetical protein; Provisional; Region: PRK06834 448385013855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385013856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385013857 Chlorite dismutase; Region: Chlor_dismutase; cl01280 448385013858 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 448385013859 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 448385013860 classical (c) SDRs; Region: SDR_c; cd05233 448385013861 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 448385013862 NAD(P) binding site [chemical binding]; other site 448385013863 active site 448385013864 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 448385013865 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385013866 non-specific DNA binding site [nucleotide binding]; other site 448385013867 salt bridge; other site 448385013868 sequence-specific DNA binding site [nucleotide binding]; other site 448385013869 Cupin domain; Region: Cupin_2; pfam07883 448385013870 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 448385013871 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 448385013872 Protein of unknown function (DUF877); Region: DUF877; pfam05943 448385013873 Protein of unknown function (DUF770); Region: DUF770; pfam05591 448385013874 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 448385013875 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 448385013876 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 448385013877 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 448385013878 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 448385013879 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 448385013880 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 448385013881 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 448385013882 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 448385013883 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 448385013884 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 448385013885 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 448385013886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013887 Walker A motif; other site 448385013888 ATP binding site [chemical binding]; other site 448385013889 Walker B motif; other site 448385013890 arginine finger; other site 448385013891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013892 Walker A motif; other site 448385013893 ATP binding site [chemical binding]; other site 448385013894 Walker B motif; other site 448385013895 arginine finger; other site 448385013896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385013897 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385013898 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385013899 catalytic residue [active] 448385013900 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385013901 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385013902 phosphopeptide binding site; other site 448385013903 Protein of unknown function (DUF796); Region: DUF796; cl01226 448385013904 Protein of unknown function (DUF796); Region: DUF796; cl01226 448385013905 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 448385013906 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 448385013907 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 448385013908 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 448385013909 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 448385013910 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 448385013911 Found in ATP-dependent protease La (LON); Region: LON; smart00464 448385013912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385013913 Walker A motif; other site 448385013914 ATP binding site [chemical binding]; other site 448385013915 Walker B motif; other site 448385013916 arginine finger; other site 448385013917 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385013918 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385013919 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 448385013920 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 448385013921 putative active site [active] 448385013922 substrate binding site [chemical binding]; other site 448385013923 putative cosubstrate binding site; other site 448385013924 catalytic site [active] 448385013925 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 448385013926 substrate binding site [chemical binding]; other site 448385013927 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 448385013928 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 448385013929 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 448385013930 NAD(P) binding site [chemical binding]; other site 448385013931 catalytic residues [active] 448385013932 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 448385013933 intersubunit interface [polypeptide binding]; other site 448385013934 active site 448385013935 catalytic residue [active] 448385013936 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 448385013937 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385013938 catalytic triad [active] 448385013939 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 448385013940 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 448385013941 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 448385013942 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 448385013943 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385013944 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385013945 active site 448385013946 ATP binding site [chemical binding]; other site 448385013947 substrate binding site [chemical binding]; other site 448385013948 activation loop (A-loop); other site 448385013949 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 448385013950 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 448385013951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385013952 TPR repeat; Region: TPR_11; pfam13414 448385013953 TPR motif; other site 448385013954 binding surface 448385013955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385013956 AAA domain; Region: AAA_21; pfam13304 448385013957 Walker A/P-loop; other site 448385013958 ATP binding site [chemical binding]; other site 448385013959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385013960 Walker B; other site 448385013961 D-loop; other site 448385013962 H-loop/switch region; other site 448385013963 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385013964 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385013965 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 448385013966 putative NAD(P) binding site [chemical binding]; other site 448385013967 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 448385013968 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385013969 B12 binding site [chemical binding]; other site 448385013970 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385013971 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385013972 putative active site [active] 448385013973 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 448385013974 oligomeric interface; other site 448385013975 putative active site [active] 448385013976 homodimer interface [polypeptide binding]; other site 448385013977 Domain of unknown function (DUF362); Region: DUF362; pfam04015 448385013978 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385013979 Family of unknown function (DUF490); Region: DUF490; pfam04357 448385013980 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 448385013981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385013982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385013983 DNA binding residues [nucleotide binding] 448385013984 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 448385013985 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 448385013986 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 448385013987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385013988 dimer interface [polypeptide binding]; other site 448385013989 conserved gate region; other site 448385013990 putative PBP binding loops; other site 448385013991 ABC-ATPase subunit interface; other site 448385013992 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 448385013993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385013994 dimer interface [polypeptide binding]; other site 448385013995 conserved gate region; other site 448385013996 putative PBP binding loops; other site 448385013997 ABC-ATPase subunit interface; other site 448385013998 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 448385013999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 448385014000 isochorismate synthase DhbC; Validated; Region: PRK06923 448385014001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 448385014002 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 448385014003 Glutamine amidotransferase class-I; Region: GATase; pfam00117 448385014004 glutamine binding [chemical binding]; other site 448385014005 catalytic triad [active] 448385014006 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 448385014007 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 448385014008 chorismate binding enzyme; Region: Chorismate_bind; cl10555 448385014009 anthranilate synthase; Provisional; Region: PRK13566 448385014010 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 448385014011 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 448385014012 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 448385014013 glutamine binding [chemical binding]; other site 448385014014 catalytic triad [active] 448385014015 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 448385014016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 448385014017 argininosuccinate synthase; Validated; Region: PRK05370 448385014018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385014019 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385014020 active site 448385014021 catalytic tetrad [active] 448385014022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385014023 Walker A/P-loop; other site 448385014024 ATP binding site [chemical binding]; other site 448385014025 Q-loop/lid; other site 448385014026 ABC transporter signature motif; other site 448385014027 Walker B; other site 448385014028 D-loop; other site 448385014029 H-loop/switch region; other site 448385014030 BON domain; Region: BON; pfam04972 448385014031 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385014032 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014033 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014034 active site 448385014035 ATP binding site [chemical binding]; other site 448385014036 substrate binding site [chemical binding]; other site 448385014037 activation loop (A-loop); other site 448385014038 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 448385014039 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 448385014040 dimer interface [polypeptide binding]; other site 448385014041 active site 448385014042 CoA binding pocket [chemical binding]; other site 448385014043 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 448385014044 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385014045 minor groove reading motif; other site 448385014046 helix-hairpin-helix signature motif; other site 448385014047 substrate binding pocket [chemical binding]; other site 448385014048 active site 448385014049 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385014050 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385014051 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 448385014052 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 448385014053 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 448385014054 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385014055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385014056 active site 448385014057 metal binding site [ion binding]; metal-binding site 448385014058 putative phosphoesterase; Region: acc_ester; TIGR03729 448385014059 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 448385014060 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 448385014061 active site 448385014062 dimer interface [polypeptide binding]; other site 448385014063 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 448385014064 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 448385014065 active site 448385014066 FMN binding site [chemical binding]; other site 448385014067 substrate binding site [chemical binding]; other site 448385014068 3Fe-4S cluster binding site [ion binding]; other site 448385014069 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 448385014070 domain interface; other site 448385014071 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 448385014072 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385014073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385014074 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 448385014075 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385014076 putative NAD(P) binding site [chemical binding]; other site 448385014077 catalytic Zn binding site [ion binding]; other site 448385014078 structural Zn binding site [ion binding]; other site 448385014079 GRAS family transcription factor; Region: GRAS; pfam03514 448385014080 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385014081 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385014082 phosphopeptide binding site; other site 448385014083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014084 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385014085 Walker A motif; other site 448385014086 ATP binding site [chemical binding]; other site 448385014087 Walker B motif; other site 448385014088 arginine finger; other site 448385014089 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385014090 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385014091 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385014092 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385014093 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 448385014094 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 448385014095 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385014096 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 448385014097 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385014098 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 448385014099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014100 active site 448385014101 phosphorylation site [posttranslational modification] 448385014102 intermolecular recognition site; other site 448385014103 dimerization interface [polypeptide binding]; other site 448385014104 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385014105 DNA binding site [nucleotide binding] 448385014106 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 448385014107 trimer interface [polypeptide binding]; other site 448385014108 active site 448385014109 substrate binding site [chemical binding]; other site 448385014110 CoA binding site [chemical binding]; other site 448385014111 Protease prsW family; Region: PrsW-protease; pfam13367 448385014112 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 448385014113 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 448385014114 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 448385014115 active site 448385014116 putative DNA-binding cleft [nucleotide binding]; other site 448385014117 dimer interface [polypeptide binding]; other site 448385014118 FAD binding domain; Region: FAD_binding_4; pfam01565 448385014119 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 448385014120 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 448385014121 TPR repeat; Region: TPR_11; pfam13414 448385014122 PEGA domain; Region: PEGA; pfam08308 448385014123 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014124 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014125 active site 448385014126 ATP binding site [chemical binding]; other site 448385014127 substrate binding site [chemical binding]; other site 448385014128 activation loop (A-loop); other site 448385014129 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 448385014130 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 448385014131 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 448385014132 Uncharacterized conserved protein [Function unknown]; Region: COG0432 448385014133 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 448385014134 heme-binding site [chemical binding]; other site 448385014135 GAF domain; Region: GAF; pfam01590 448385014136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014137 Walker A motif; other site 448385014138 ATP binding site [chemical binding]; other site 448385014139 Walker B motif; other site 448385014140 arginine finger; other site 448385014141 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 448385014142 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 448385014143 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 448385014144 active site 448385014145 Zn binding site [ion binding]; other site 448385014146 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 448385014147 active site 448385014148 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 448385014149 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 448385014150 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385014151 C-terminal domain interface [polypeptide binding]; other site 448385014152 GSH binding site (G-site) [chemical binding]; other site 448385014153 dimer interface [polypeptide binding]; other site 448385014154 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385014155 dimer interface [polypeptide binding]; other site 448385014156 N-terminal domain interface [polypeptide binding]; other site 448385014157 substrate binding pocket (H-site) [chemical binding]; other site 448385014158 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 448385014159 active site 448385014160 catalytic site [active] 448385014161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385014162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385014163 phosphopeptide binding site; other site 448385014164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014165 Walker A motif; other site 448385014166 ATP binding site [chemical binding]; other site 448385014167 Walker B motif; other site 448385014168 arginine finger; other site 448385014169 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385014170 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 448385014171 active site 448385014172 SUMO-1 interface [polypeptide binding]; other site 448385014173 Response regulator receiver domain; Region: Response_reg; pfam00072 448385014174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014175 active site 448385014176 phosphorylation site [posttranslational modification] 448385014177 intermolecular recognition site; other site 448385014178 dimerization interface [polypeptide binding]; other site 448385014179 PAS domain S-box; Region: sensory_box; TIGR00229 448385014180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014181 putative active site [active] 448385014182 heme pocket [chemical binding]; other site 448385014183 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385014184 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385014185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014186 PAS fold; Region: PAS_3; pfam08447 448385014187 putative active site [active] 448385014188 heme pocket [chemical binding]; other site 448385014189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385014190 dimer interface [polypeptide binding]; other site 448385014191 phosphorylation site [posttranslational modification] 448385014192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014193 ATP binding site [chemical binding]; other site 448385014194 Mg2+ binding site [ion binding]; other site 448385014195 G-X-G motif; other site 448385014196 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385014197 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385014198 ligand binding site [chemical binding]; other site 448385014199 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385014200 FOG: CBS domain [General function prediction only]; Region: COG0517 448385014201 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385014202 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385014203 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 448385014204 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014205 dimerization interface [polypeptide binding]; other site 448385014206 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 448385014207 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014208 dimerization interface [polypeptide binding]; other site 448385014209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014210 dimerization interface [polypeptide binding]; other site 448385014211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014212 dimerization interface [polypeptide binding]; other site 448385014213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014214 dimerization interface [polypeptide binding]; other site 448385014215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014216 dimerization interface [polypeptide binding]; other site 448385014217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385014218 GAF domain; Region: GAF_3; pfam13492 448385014219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385014220 dimer interface [polypeptide binding]; other site 448385014221 phosphorylation site [posttranslational modification] 448385014222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014223 ATP binding site [chemical binding]; other site 448385014224 Mg2+ binding site [ion binding]; other site 448385014225 G-X-G motif; other site 448385014226 Response regulator receiver domain; Region: Response_reg; pfam00072 448385014227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014228 active site 448385014229 phosphorylation site [posttranslational modification] 448385014230 intermolecular recognition site; other site 448385014231 dimerization interface [polypeptide binding]; other site 448385014232 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385014233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014234 phosphorylation site [posttranslational modification] 448385014235 intermolecular recognition site; other site 448385014236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014237 Response regulator receiver domain; Region: Response_reg; pfam00072 448385014238 active site 448385014239 phosphorylation site [posttranslational modification] 448385014240 intermolecular recognition site; other site 448385014241 dimerization interface [polypeptide binding]; other site 448385014242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014244 active site 448385014245 ATP binding site [chemical binding]; other site 448385014246 substrate binding site [chemical binding]; other site 448385014247 activation loop (A-loop); other site 448385014248 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 448385014249 putative active site [active] 448385014250 catalytic site [active] 448385014251 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 448385014252 PLD-like domain; Region: PLDc_2; pfam13091 448385014253 putative active site [active] 448385014254 catalytic site [active] 448385014255 Predicted membrane protein [Function unknown]; Region: COG2323 448385014256 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 448385014257 Glucose inhibited division protein A; Region: GIDA; pfam01134 448385014258 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 448385014259 DNA topoisomerase I; Validated; Region: PRK06599 448385014260 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 448385014261 active site 448385014262 interdomain interaction site; other site 448385014263 putative metal-binding site [ion binding]; other site 448385014264 nucleotide binding site [chemical binding]; other site 448385014265 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 448385014266 domain I; other site 448385014267 DNA binding groove [nucleotide binding] 448385014268 phosphate binding site [ion binding]; other site 448385014269 domain II; other site 448385014270 domain III; other site 448385014271 nucleotide binding site [chemical binding]; other site 448385014272 catalytic site [active] 448385014273 domain IV; other site 448385014274 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 448385014275 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 448385014276 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 448385014277 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 448385014278 DNA protecting protein DprA; Region: dprA; TIGR00732 448385014279 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 448385014280 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 448385014281 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 448385014282 active site 448385014283 catalytic site [active] 448385014284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014286 active site 448385014287 ATP binding site [chemical binding]; other site 448385014288 substrate binding site [chemical binding]; other site 448385014289 activation loop (A-loop); other site 448385014290 Restriction endonuclease; Region: Mrr_cat; pfam04471 448385014291 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 448385014292 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 448385014293 motif 1; other site 448385014294 active site 448385014295 motif 2; other site 448385014296 motif 3; other site 448385014297 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 448385014298 DHHA1 domain; Region: DHHA1; pfam02272 448385014299 HEAT repeats; Region: HEAT_2; pfam13646 448385014300 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385014301 ligand binding site [chemical binding]; other site 448385014302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014304 active site 448385014305 ATP binding site [chemical binding]; other site 448385014306 substrate binding site [chemical binding]; other site 448385014307 activation loop (A-loop); other site 448385014308 AAA ATPase domain; Region: AAA_16; pfam13191 448385014309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385014310 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385014311 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385014312 structural tetrad; other site 448385014313 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385014314 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385014315 structural tetrad; other site 448385014316 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385014317 Caspase domain; Region: Peptidase_C14; pfam00656 448385014318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014319 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014320 active site 448385014321 ATP binding site [chemical binding]; other site 448385014322 substrate binding site [chemical binding]; other site 448385014323 activation loop (A-loop); other site 448385014324 AAA ATPase domain; Region: AAA_16; pfam13191 448385014325 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 448385014326 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385014327 active site 448385014328 HIGH motif; other site 448385014329 nucleotide binding site [chemical binding]; other site 448385014330 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385014331 active site 448385014332 KMSKS motif; other site 448385014333 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 448385014334 tRNA binding surface [nucleotide binding]; other site 448385014335 anticodon binding site; other site 448385014336 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 448385014337 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 448385014338 FAD binding pocket [chemical binding]; other site 448385014339 conserved FAD binding motif [chemical binding]; other site 448385014340 phosphate binding motif [ion binding]; other site 448385014341 beta-alpha-beta structure motif; other site 448385014342 NAD binding pocket [chemical binding]; other site 448385014343 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 448385014344 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014346 active site 448385014347 ATP binding site [chemical binding]; other site 448385014348 substrate binding site [chemical binding]; other site 448385014349 activation loop (A-loop); other site 448385014350 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014351 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014352 active site 448385014353 ATP binding site [chemical binding]; other site 448385014354 substrate binding site [chemical binding]; other site 448385014355 activation loop (A-loop); other site 448385014356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014358 active site 448385014359 ATP binding site [chemical binding]; other site 448385014360 substrate binding site [chemical binding]; other site 448385014361 activation loop (A-loop); other site 448385014362 RNA polymerase factor sigma-70; Validated; Region: PRK08241 448385014363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385014364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385014365 DNA binding residues [nucleotide binding] 448385014366 SnoaL-like domain; Region: SnoaL_2; pfam12680 448385014367 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 448385014368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385014369 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 448385014370 putative hydrophobic ligand binding site [chemical binding]; other site 448385014371 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 448385014372 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 448385014373 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 448385014374 YCII-related domain; Region: YCII; cl00999 448385014375 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 448385014376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385014377 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385014378 putative transporter; Provisional; Region: PRK11660 448385014379 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 448385014380 Sulfate transporter family; Region: Sulfate_transp; pfam00916 448385014381 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 448385014382 pantothenate kinase; Provisional; Region: PRK05439 448385014383 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 448385014384 ATP-binding site [chemical binding]; other site 448385014385 CoA-binding site [chemical binding]; other site 448385014386 Mg2+-binding site [ion binding]; other site 448385014387 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 448385014388 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 448385014389 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 448385014390 active site 448385014391 intersubunit interface [polypeptide binding]; other site 448385014392 catalytic residue [active] 448385014393 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 448385014394 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 448385014395 substrate binding site [chemical binding]; other site 448385014396 ATP binding site [chemical binding]; other site 448385014397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385014398 D-galactonate transporter; Region: 2A0114; TIGR00893 448385014399 putative substrate translocation pore; other site 448385014400 D-mannonate oxidoreductase; Provisional; Region: PRK08277 448385014401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385014402 NAD(P) binding site [chemical binding]; other site 448385014403 active site 448385014404 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 448385014405 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 448385014406 metal binding site [ion binding]; metal-binding site 448385014407 substrate binding pocket [chemical binding]; other site 448385014408 PAS fold; Region: PAS_4; pfam08448 448385014409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014410 putative active site [active] 448385014411 heme pocket [chemical binding]; other site 448385014412 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385014413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 448385014414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385014415 Coenzyme A binding pocket [chemical binding]; other site 448385014416 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014417 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014418 active site 448385014419 ATP binding site [chemical binding]; other site 448385014420 substrate binding site [chemical binding]; other site 448385014421 activation loop (A-loop); other site 448385014422 Response regulator receiver domain; Region: Response_reg; pfam00072 448385014423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014424 active site 448385014425 phosphorylation site [posttranslational modification] 448385014426 intermolecular recognition site; other site 448385014427 dimerization interface [polypeptide binding]; other site 448385014428 Response regulator receiver domain; Region: Response_reg; pfam00072 448385014429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014430 active site 448385014431 phosphorylation site [posttranslational modification] 448385014432 intermolecular recognition site; other site 448385014433 dimerization interface [polypeptide binding]; other site 448385014434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385014435 dimerization interface [polypeptide binding]; other site 448385014436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385014437 dimer interface [polypeptide binding]; other site 448385014438 phosphorylation site [posttranslational modification] 448385014439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014440 ATP binding site [chemical binding]; other site 448385014441 Mg2+ binding site [ion binding]; other site 448385014442 G-X-G motif; other site 448385014443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014444 ATP binding site [chemical binding]; other site 448385014445 Mg2+ binding site [ion binding]; other site 448385014446 G-X-G motif; other site 448385014447 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385014448 active site 448385014449 catalytic triad [active] 448385014450 oxyanion hole [active] 448385014451 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385014452 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385014453 structural tetrad; other site 448385014454 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385014455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385014456 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385014457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385014458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385014459 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385014460 active site 448385014461 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014462 active site 448385014463 ATP binding site [chemical binding]; other site 448385014464 substrate binding site [chemical binding]; other site 448385014465 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 448385014466 activation loop (A-loop); other site 448385014467 cyclase homology domain; Region: CHD; cd07302 448385014468 dimer interface [polypeptide binding]; other site 448385014469 nucleotidyl binding site; other site 448385014470 metal binding site [ion binding]; metal-binding site 448385014471 AAA ATPase domain; Region: AAA_16; pfam13191 448385014472 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 448385014473 Amidohydrolase; Region: Amidohydro_2; pfam04909 448385014474 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 448385014475 YcaO-like family; Region: YcaO; pfam02624 448385014476 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 448385014477 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385014478 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385014479 phosphopeptide binding site; other site 448385014480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385014481 I-site; other site 448385014482 active site 448385014483 metal binding site [ion binding]; metal-binding site 448385014484 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385014485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014486 Walker A motif; other site 448385014487 ATP binding site [chemical binding]; other site 448385014488 Walker B motif; other site 448385014489 arginine finger; other site 448385014490 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385014491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385014492 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 448385014493 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 448385014494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385014495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385014496 dimer interface [polypeptide binding]; other site 448385014497 phosphorylation site [posttranslational modification] 448385014498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014499 ATP binding site [chemical binding]; other site 448385014500 Mg2+ binding site [ion binding]; other site 448385014501 G-X-G motif; other site 448385014502 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 448385014503 hypothetical protein; Provisional; Region: PRK07877 448385014504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385014505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385014506 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385014507 substrate binding pocket [chemical binding]; other site 448385014508 dimerization interface [polypeptide binding]; other site 448385014509 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 448385014510 active site 448385014511 catalytic triad [active] 448385014512 Cupin domain; Region: Cupin_2; pfam07883 448385014513 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 448385014514 [2Fe-2S] cluster binding site [ion binding]; other site 448385014515 iron-sulfur cluster [ion binding]; other site 448385014516 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 448385014517 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 448385014518 Cupin domain; Region: Cupin_2; cl17218 448385014519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385014520 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 448385014521 Walker A/P-loop; other site 448385014522 ATP binding site [chemical binding]; other site 448385014523 Q-loop/lid; other site 448385014524 ABC transporter signature motif; other site 448385014525 Walker B; other site 448385014526 D-loop; other site 448385014527 H-loop/switch region; other site 448385014528 pyruvate kinase; Validated; Region: PRK08187 448385014529 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 448385014530 domain interfaces; other site 448385014531 active site 448385014532 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 448385014533 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385014534 dimerization interface [polypeptide binding]; other site 448385014535 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385014536 ligand binding site [chemical binding]; other site 448385014537 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385014538 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385014539 Uncharacterized conserved protein [Function unknown]; Region: COG5439 448385014540 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385014541 dimerization interface [polypeptide binding]; other site 448385014542 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385014543 ligand binding site [chemical binding]; other site 448385014544 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385014545 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385014546 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385014547 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385014548 dimerization interface [polypeptide binding]; other site 448385014549 ligand binding site [chemical binding]; other site 448385014550 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385014551 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385014552 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014553 active site 448385014554 ATP binding site [chemical binding]; other site 448385014555 substrate binding site [chemical binding]; other site 448385014556 activation loop (A-loop); other site 448385014557 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385014558 putative active site [active] 448385014559 Protein kinase domain; Region: Pkinase; pfam00069 448385014560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014561 active site 448385014562 ATP binding site [chemical binding]; other site 448385014563 substrate binding site [chemical binding]; other site 448385014564 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385014565 substrate binding site [chemical binding]; other site 448385014566 activation loop (A-loop); other site 448385014567 activation loop (A-loop); other site 448385014568 Predicted ATPase [General function prediction only]; Region: COG3899 448385014569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014570 Walker A motif; other site 448385014571 ATP binding site [chemical binding]; other site 448385014572 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385014573 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385014574 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385014575 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385014576 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385014577 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385014578 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385014579 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385014580 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385014581 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 448385014582 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 448385014583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385014584 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385014585 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 448385014586 active site 448385014587 catalytic triad [active] 448385014588 oxyanion hole [active] 448385014589 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 448385014590 WYL domain; Region: WYL; pfam13280 448385014591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014593 active site 448385014594 ATP binding site [chemical binding]; other site 448385014595 substrate binding site [chemical binding]; other site 448385014596 activation loop (A-loop); other site 448385014597 Predicted ATPase [General function prediction only]; Region: COG3903 448385014598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385014599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385014600 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385014601 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385014602 CoenzymeA binding site [chemical binding]; other site 448385014603 subunit interaction site [polypeptide binding]; other site 448385014604 PHB binding site; other site 448385014605 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385014606 BON domain; Region: BON; pfam04972 448385014607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385014608 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385014609 FeS/SAM binding site; other site 448385014610 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014612 active site 448385014613 ATP binding site [chemical binding]; other site 448385014614 substrate binding site [chemical binding]; other site 448385014615 activation loop (A-loop); other site 448385014616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 448385014617 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 448385014618 Haem-binding domain; Region: Haem_bd; pfam14376 448385014619 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 448385014620 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385014621 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014622 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014623 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014624 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014625 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014626 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014627 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014628 PA14 domain; Region: PA14; cl08459 448385014629 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014630 ATPase involved in DNA repair; Region: DUF3686; pfam12458 448385014631 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 448385014632 linker region; other site 448385014633 AAA domain; Region: AAA_22; pfam13401 448385014634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385014635 Walker A motif; other site 448385014636 ATP binding site [chemical binding]; other site 448385014637 Walker B motif; other site 448385014638 arginine finger; other site 448385014639 FIST N domain; Region: FIST; pfam08495 448385014640 FIST C domain; Region: FIST_C; pfam10442 448385014641 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 448385014642 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 448385014643 NAD binding site [chemical binding]; other site 448385014644 dimer interface [polypeptide binding]; other site 448385014645 substrate binding site [chemical binding]; other site 448385014646 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385014647 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385014648 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385014649 CoA binding domain; Region: CoA_binding; cl17356 448385014650 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 448385014651 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 448385014652 chaperone protein DnaJ; Provisional; Region: PRK10767 448385014653 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 448385014654 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385014655 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 448385014656 tellurite resistance protein terB; Region: terB; cd07176 448385014657 putative metal binding site [ion binding]; other site 448385014658 Domain of unknown function (DUF814); Region: DUF814; pfam05670 448385014659 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385014660 CBD_II domain; Region: CBD_II; smart00637 448385014661 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 448385014662 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 448385014663 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 448385014664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385014665 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385014666 active site 448385014667 catalytic tetrad [active] 448385014668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385014669 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 448385014670 cofactor binding site; other site 448385014671 metal binding site [ion binding]; metal-binding site 448385014672 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 448385014673 VanW like protein; Region: VanW; pfam04294 448385014674 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 448385014675 thiS-thiF/thiG interaction site; other site 448385014676 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 448385014677 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 448385014678 trimer interface [polypeptide binding]; other site 448385014679 putative metal binding site [ion binding]; other site 448385014680 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 448385014681 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 448385014682 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385014683 FeS/SAM binding site; other site 448385014684 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 448385014685 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385014686 acyl-activating enzyme (AAE) consensus motif; other site 448385014687 AMP binding site [chemical binding]; other site 448385014688 active site 448385014689 CoA binding site [chemical binding]; other site 448385014690 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 448385014691 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385014692 TAP-like protein; Region: Abhydrolase_4; pfam08386 448385014693 Protein required for attachment to host cells; Region: Host_attach; pfam10116 448385014694 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 448385014695 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 448385014696 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 448385014697 Substrate binding site; other site 448385014698 Mg++ binding site; other site 448385014699 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 448385014700 active site 448385014701 substrate binding site [chemical binding]; other site 448385014702 CoA binding site [chemical binding]; other site 448385014703 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 448385014704 Catalytic site [active] 448385014705 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 448385014706 Uncharacterized conserved protein [Function unknown]; Region: COG3461 448385014707 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 448385014708 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 448385014709 dimerization interface [polypeptide binding]; other site 448385014710 active site 448385014711 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 448385014712 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385014713 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385014714 active site 448385014715 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 448385014716 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 448385014717 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385014718 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385014719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385014720 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385014721 hypothetical protein; Provisional; Region: PRK08317 448385014722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385014723 S-adenosylmethionine binding site [chemical binding]; other site 448385014724 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385014725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385014726 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385014727 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 448385014728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385014729 motif II; other site 448385014730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385014731 AAA domain; Region: AAA_23; pfam13476 448385014732 AAA domain; Region: AAA_21; pfam13304 448385014733 Walker A/P-loop; other site 448385014734 ATP binding site [chemical binding]; other site 448385014735 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385014736 Q-loop/lid; other site 448385014737 ABC transporter signature motif; other site 448385014738 Walker B; other site 448385014739 D-loop; other site 448385014740 H-loop/switch region; other site 448385014741 PAS domain; Region: PAS_9; pfam13426 448385014742 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385014743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385014744 Walker A/P-loop; other site 448385014745 ATP binding site [chemical binding]; other site 448385014746 Q-loop/lid; other site 448385014747 ABC transporter signature motif; other site 448385014748 Walker B; other site 448385014749 D-loop; other site 448385014750 H-loop/switch region; other site 448385014751 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 448385014752 DNA polymerase III, delta subunit; Region: holA; TIGR01128 448385014753 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 448385014754 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 448385014755 transmembrane helices; other site 448385014756 phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521 448385014757 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385014758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385014759 NAD(P) binding site [chemical binding]; other site 448385014760 active site 448385014761 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385014762 B12 binding site [chemical binding]; other site 448385014763 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385014764 CAAX protease self-immunity; Region: Abi; pfam02517 448385014765 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385014766 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385014767 ligand binding site [chemical binding]; other site 448385014768 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 448385014769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385014770 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385014771 ATP binding site [chemical binding]; other site 448385014772 putative Mg++ binding site [ion binding]; other site 448385014773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385014774 nucleotide binding region [chemical binding]; other site 448385014775 ATP-binding site [chemical binding]; other site 448385014776 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 448385014777 RNA binding site [nucleotide binding]; other site 448385014778 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 448385014779 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 448385014780 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 448385014781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385014782 substrate binding site [chemical binding]; other site 448385014783 oxyanion hole (OAH) forming residues; other site 448385014784 trimer interface [polypeptide binding]; other site 448385014785 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385014786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014787 putative active site [active] 448385014788 heme pocket [chemical binding]; other site 448385014789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014790 putative active site [active] 448385014791 heme pocket [chemical binding]; other site 448385014792 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385014793 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 448385014794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014796 active site 448385014797 ATP binding site [chemical binding]; other site 448385014798 substrate binding site [chemical binding]; other site 448385014799 activation loop (A-loop); other site 448385014800 N-terminal protein-binding module of harmonin and similar domains; Region: harmonin_N_like; cl11968 448385014801 putative protein binding pocket; other site 448385014802 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385014803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014804 active site 448385014805 ATP binding site [chemical binding]; other site 448385014806 substrate binding site [chemical binding]; other site 448385014807 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385014808 substrate binding site [chemical binding]; other site 448385014809 activation loop (A-loop); other site 448385014810 activation loop (A-loop); other site 448385014811 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014812 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014813 active site 448385014814 ATP binding site [chemical binding]; other site 448385014815 substrate binding site [chemical binding]; other site 448385014816 activation loop (A-loop); other site 448385014817 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 448385014818 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385014819 active site 448385014820 HIGH motif; other site 448385014821 nucleotide binding site [chemical binding]; other site 448385014822 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 448385014823 KMSKS motif; other site 448385014824 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 448385014825 anticodon binding site; other site 448385014826 tRNA binding surface [nucleotide binding]; other site 448385014827 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 448385014828 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 448385014829 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 448385014830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385014831 Walker A motif; other site 448385014832 ATP binding site [chemical binding]; other site 448385014833 Walker B motif; other site 448385014834 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 448385014835 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385014836 Walker A motif; other site 448385014837 ATP binding site [chemical binding]; other site 448385014838 Walker B motif; other site 448385014839 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 448385014840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385014841 S-adenosylmethionine binding site [chemical binding]; other site 448385014842 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 448385014843 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385014844 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385014845 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 448385014846 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 448385014847 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 448385014848 putative di-iron ligands [ion binding]; other site 448385014849 hypothetical protein; Provisional; Region: PRK13665 448385014850 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 448385014851 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 448385014852 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 448385014853 dimer interface [polypeptide binding]; other site 448385014854 active site residues [active] 448385014855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385014856 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 448385014857 nucleophilic elbow; other site 448385014858 catalytic triad; other site 448385014859 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385014860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014862 active site 448385014863 ATP binding site [chemical binding]; other site 448385014864 substrate binding site [chemical binding]; other site 448385014865 activation loop (A-loop); other site 448385014866 Predicted ATPase [General function prediction only]; Region: COG3899 448385014867 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385014868 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385014869 active site 448385014870 ATP binding site [chemical binding]; other site 448385014871 substrate binding site [chemical binding]; other site 448385014872 activation loop (A-loop); other site 448385014873 aromatic amino acid exporter; Provisional; Region: PRK11689 448385014874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385014875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385014876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385014877 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385014878 active site 448385014879 TIGR02452 family protein; Region: TIGR02452 448385014880 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 448385014881 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385014882 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385014883 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 448385014884 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 448385014885 oligomer interface; other site 448385014886 ligand binding site; other site 448385014887 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 448385014888 dimer interface [polypeptide binding]; other site 448385014889 N-terminal domain interface [polypeptide binding]; other site 448385014890 sulfate 1 binding site; other site 448385014891 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 448385014892 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 448385014893 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385014894 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 448385014895 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014896 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385014897 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014898 PA14 domain; Region: PA14; cl08459 448385014899 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385014900 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385014901 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 448385014902 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385014903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385014904 active site 448385014905 phosphorylation site [posttranslational modification] 448385014906 intermolecular recognition site; other site 448385014907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385014908 PAS fold; Region: PAS_3; pfam08447 448385014909 putative active site [active] 448385014910 heme pocket [chemical binding]; other site 448385014911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385014912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385014913 ATP binding site [chemical binding]; other site 448385014914 Mg2+ binding site [ion binding]; other site 448385014915 G-X-G motif; other site 448385014916 Kelch domain; Region: Kelch; smart00612 448385014917 Kelch motif; Region: Kelch_2; pfam07646 448385014918 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385014919 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385014920 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385014921 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385014922 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385014923 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385014924 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 448385014925 Gram-negative bacterial tonB protein; Region: TonB; cl10048 448385014926 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 448385014927 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385014928 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 448385014929 Lamin Tail Domain; Region: LTD; pfam00932 448385014930 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385014931 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 448385014932 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385014933 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014934 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014935 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014936 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385014937 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014938 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385014939 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014940 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385014941 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014942 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014943 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385014944 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014945 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385014946 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 448385014947 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 448385014948 active site 448385014949 zinc binding site [ion binding]; other site 448385014950 oxidoreductase; Provisional; Region: PRK06196 448385014951 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 448385014952 putative NAD(P) binding site [chemical binding]; other site 448385014953 active site 448385014954 CARDB; Region: CARDB; pfam07705 448385014955 CARDB; Region: CARDB; pfam07705 448385014956 CARDB; Region: CARDB; pfam07705 448385014957 CARDB; Region: CARDB; pfam07705 448385014958 CARDB; Region: CARDB; pfam07705 448385014959 CARDB; Region: CARDB; pfam07705 448385014960 CARDB; Region: CARDB; pfam07705 448385014961 CARDB; Region: CARDB; pfam07705 448385014962 CARDB; Region: CARDB; pfam07705 448385014963 CARDB; Region: CARDB; pfam07705 448385014964 CARDB; Region: CARDB; pfam07705 448385014965 CARDB; Region: CARDB; pfam07705 448385014966 CARDB; Region: CARDB; pfam07705 448385014967 CARDB; Region: CARDB; pfam07705 448385014968 Serine hydrolase; Region: Ser_hydrolase; pfam06821 448385014969 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385014970 NADH(P)-binding; Region: NAD_binding_10; pfam13460 448385014971 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385014972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385014973 active site 448385014974 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385014975 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 448385014976 NAD(P) binding site [chemical binding]; other site 448385014977 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 448385014978 uncharacterized ygcE-like proteins; Region: FGGY_ygcE_like; cd07779 448385014979 putative N- and C-terminal domain interface [polypeptide binding]; other site 448385014980 putative active site [active] 448385014981 MgATP binding site [chemical binding]; other site 448385014982 catalytic site [active] 448385014983 metal binding site [ion binding]; metal-binding site 448385014984 putative carbohydrate binding site [chemical binding]; other site 448385014985 serpin-like protein; Provisional; Region: PHA02660 448385014986 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385014987 reactive center loop; other site 448385014988 serpin-like protein; Provisional; Region: PHA02660 448385014989 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385014990 reactive center loop; other site 448385014991 PemK-like protein; Region: PemK; pfam02452 448385014992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385014993 MarR family; Region: MarR; pfam01047 448385014994 Uncharacterized conserved protein [Function unknown]; Region: COG2128 448385014995 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 448385014996 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 448385014997 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385014998 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 448385014999 active site 448385015000 catalytic triad [active] 448385015001 oxyanion hole [active] 448385015002 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 448385015003 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 448385015004 SelR domain; Region: SelR; pfam01641 448385015005 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 448385015006 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 448385015007 active site 448385015008 NAD binding site [chemical binding]; other site 448385015009 metal binding site [ion binding]; metal-binding site 448385015010 Phosphotransferase enzyme family; Region: APH; pfam01636 448385015011 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 448385015012 active site 448385015013 substrate binding site [chemical binding]; other site 448385015014 ATP binding site [chemical binding]; other site 448385015015 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 448385015016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 448385015017 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385015018 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385015019 putative C-terminal domain interface [polypeptide binding]; other site 448385015020 putative GSH binding site (G-site) [chemical binding]; other site 448385015021 putative dimer interface [polypeptide binding]; other site 448385015022 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 448385015023 dimer interface [polypeptide binding]; other site 448385015024 N-terminal domain interface [polypeptide binding]; other site 448385015025 putative substrate binding pocket (H-site) [chemical binding]; other site 448385015026 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 448385015027 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 448385015028 OB-fold nucleic acid binding domain; Region: tRNA_anti_2; pfam13742 448385015029 generic binding surface II; other site 448385015030 generic binding surface I; other site 448385015031 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 448385015032 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 448385015033 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 448385015034 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 448385015035 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 448385015036 active site 448385015037 FMN binding site [chemical binding]; other site 448385015038 substrate binding site [chemical binding]; other site 448385015039 putative catalytic residue [active] 448385015040 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385015041 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 448385015042 Trp docking motif [polypeptide binding]; other site 448385015043 active site 448385015044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015045 AAA domain; Region: AAA_22; pfam13401 448385015046 Walker A motif; other site 448385015047 ATP binding site [chemical binding]; other site 448385015048 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 448385015049 AAA-like domain; Region: AAA_10; pfam12846 448385015050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015051 Walker A motif; other site 448385015052 ATP binding site [chemical binding]; other site 448385015053 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385015054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385015055 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 448385015056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385015057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385015058 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385015059 Flagellin N-methylase; Region: FliB; pfam03692 448385015060 Uncharacterized conserved protein [Function unknown]; Region: COG0397 448385015061 hypothetical protein; Validated; Region: PRK00029 448385015062 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385015063 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385015064 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385015065 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385015066 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385015067 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385015068 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385015069 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385015070 LysR family transcriptional regulator; Provisional; Region: PRK14997 448385015071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385015072 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385015073 putative effector binding pocket; other site 448385015074 dimerization interface [polypeptide binding]; other site 448385015075 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385015076 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385015077 GAF domain; Region: GAF; cl17456 448385015078 GAF domain; Region: GAF_2; pfam13185 448385015079 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385015080 xylose isomerase; Provisional; Region: PRK05474 448385015081 xylose isomerase; Region: xylose_isom_A; TIGR02630 448385015082 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 448385015083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 448385015084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385015085 active site 448385015086 phosphorylation site [posttranslational modification] 448385015087 intermolecular recognition site; other site 448385015088 dimerization interface [polypeptide binding]; other site 448385015089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385015090 DNA binding residues [nucleotide binding] 448385015091 dimerization interface [polypeptide binding]; other site 448385015092 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 448385015093 Histidine kinase; Region: HisKA_3; pfam07730 448385015094 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 448385015095 Family description; Region: VCBS; pfam13517 448385015096 Family description; Region: VCBS; pfam13517 448385015097 Family description; Region: VCBS; pfam13517 448385015098 Erythromycin esterase; Region: Erythro_esteras; pfam05139 448385015099 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 448385015100 substrate binding site [chemical binding]; other site 448385015101 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 448385015102 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 448385015103 homodimer interface [polypeptide binding]; other site 448385015104 homotetramer interface [polypeptide binding]; other site 448385015105 active site pocket [active] 448385015106 cleavage site 448385015107 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015108 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015109 active site 448385015110 ATP binding site [chemical binding]; other site 448385015111 substrate binding site [chemical binding]; other site 448385015112 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385015113 substrate binding site [chemical binding]; other site 448385015114 activation loop (A-loop); other site 448385015115 activation loop (A-loop); other site 448385015116 Predicted ATPase [General function prediction only]; Region: COG3899 448385015117 AAA ATPase domain; Region: AAA_16; pfam13191 448385015118 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015119 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385015120 PAS fold; Region: PAS_4; pfam08448 448385015121 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385015122 putative active site [active] 448385015123 heme pocket [chemical binding]; other site 448385015124 GAF domain; Region: GAF_3; pfam13492 448385015125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015127 dimer interface [polypeptide binding]; other site 448385015128 phosphorylation site [posttranslational modification] 448385015129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015130 ATP binding site [chemical binding]; other site 448385015131 Mg2+ binding site [ion binding]; other site 448385015132 G-X-G motif; other site 448385015133 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015134 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015135 active site 448385015136 ATP binding site [chemical binding]; other site 448385015137 substrate binding site [chemical binding]; other site 448385015138 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385015139 substrate binding site [chemical binding]; other site 448385015140 activation loop (A-loop); other site 448385015141 activation loop (A-loop); other site 448385015142 Predicted ATPase [General function prediction only]; Region: COG3899 448385015143 AAA ATPase domain; Region: AAA_16; pfam13191 448385015144 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015145 PAS fold; Region: PAS_4; pfam08448 448385015146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015147 GAF domain; Region: GAF_3; pfam13492 448385015148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015150 dimer interface [polypeptide binding]; other site 448385015151 phosphorylation site [posttranslational modification] 448385015152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015153 ATP binding site [chemical binding]; other site 448385015154 Mg2+ binding site [ion binding]; other site 448385015155 G-X-G motif; other site 448385015156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015158 active site 448385015159 ATP binding site [chemical binding]; other site 448385015160 substrate binding site [chemical binding]; other site 448385015161 activation loop (A-loop); other site 448385015162 AAA ATPase domain; Region: AAA_16; pfam13191 448385015163 Predicted ATPase [General function prediction only]; Region: COG3899 448385015164 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015165 PAS fold; Region: PAS_4; pfam08448 448385015166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015168 dimer interface [polypeptide binding]; other site 448385015169 phosphorylation site [posttranslational modification] 448385015170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015171 ATP binding site [chemical binding]; other site 448385015172 Mg2+ binding site [ion binding]; other site 448385015173 G-X-G motif; other site 448385015174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015176 active site 448385015177 ATP binding site [chemical binding]; other site 448385015178 substrate binding site [chemical binding]; other site 448385015179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385015180 substrate binding site [chemical binding]; other site 448385015181 activation loop (A-loop); other site 448385015182 activation loop (A-loop); other site 448385015183 AAA ATPase domain; Region: AAA_16; pfam13191 448385015184 Predicted ATPase [General function prediction only]; Region: COG3899 448385015185 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015186 GAF domain; Region: GAF; cl17456 448385015187 PAS domain; Region: PAS; smart00091 448385015188 PAS fold; Region: PAS_4; pfam08448 448385015189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015190 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385015191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015192 dimer interface [polypeptide binding]; other site 448385015193 phosphorylation site [posttranslational modification] 448385015194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015195 ATP binding site [chemical binding]; other site 448385015196 Mg2+ binding site [ion binding]; other site 448385015197 G-X-G motif; other site 448385015198 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385015199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385015200 DNA binding residues [nucleotide binding] 448385015201 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 448385015202 ECF sigma factor; Region: Sigma70_ECF; pfam07638 448385015203 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385015204 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385015205 DNA binding residues [nucleotide binding] 448385015206 FecR protein; Region: FecR; pfam04773 448385015207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015208 active site 448385015209 ATP binding site [chemical binding]; other site 448385015210 substrate binding site [chemical binding]; other site 448385015211 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015212 activation loop (A-loop); other site 448385015213 AAA ATPase domain; Region: AAA_16; pfam13191 448385015214 Predicted ATPase [General function prediction only]; Region: COG3899 448385015215 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385015216 PAS fold; Region: PAS_4; pfam08448 448385015217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385015218 putative active site [active] 448385015219 heme pocket [chemical binding]; other site 448385015220 GAF domain; Region: GAF_3; pfam13492 448385015221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015223 dimer interface [polypeptide binding]; other site 448385015224 phosphorylation site [posttranslational modification] 448385015225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015226 ATP binding site [chemical binding]; other site 448385015227 Mg2+ binding site [ion binding]; other site 448385015228 G-X-G motif; other site 448385015229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 448385015230 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385015231 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 448385015232 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 448385015233 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 448385015234 putative ADP-binding pocket [chemical binding]; other site 448385015235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015237 active site 448385015238 ATP binding site [chemical binding]; other site 448385015239 substrate binding site [chemical binding]; other site 448385015240 activation loop (A-loop); other site 448385015241 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385015242 active site 448385015243 Calreticulin family; Region: Calreticulin; pfam00262 448385015244 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385015245 B12 binding site [chemical binding]; other site 448385015246 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385015247 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 448385015248 FeS/SAM binding site; other site 448385015249 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 448385015250 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 448385015251 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 448385015252 TrkA-N domain; Region: TrkA_N; pfam02254 448385015253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385015254 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385015255 phosphopeptide binding site; other site 448385015256 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385015257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015258 Walker A motif; other site 448385015259 ATP binding site [chemical binding]; other site 448385015260 Walker B motif; other site 448385015261 arginine finger; other site 448385015262 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015263 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015264 active site 448385015265 ATP binding site [chemical binding]; other site 448385015266 substrate binding site [chemical binding]; other site 448385015267 activation loop (A-loop); other site 448385015268 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 448385015269 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 448385015270 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 448385015271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385015272 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 448385015273 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385015274 motif II; other site 448385015275 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 448385015276 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 448385015277 putative ligand binding site [chemical binding]; other site 448385015278 Family description; Region: VCBS; pfam13517 448385015279 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 448385015280 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385015281 PEGA domain; Region: PEGA; pfam08308 448385015282 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385015283 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385015284 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385015285 Response regulator receiver domain; Region: Response_reg; pfam00072 448385015286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385015287 active site 448385015288 phosphorylation site [posttranslational modification] 448385015289 intermolecular recognition site; other site 448385015290 dimerization interface [polypeptide binding]; other site 448385015291 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 448385015292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385015293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015294 ATP binding site [chemical binding]; other site 448385015295 Mg2+ binding site [ion binding]; other site 448385015296 G-X-G motif; other site 448385015297 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 448385015298 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 448385015299 NAD binding site [chemical binding]; other site 448385015300 ligand binding site [chemical binding]; other site 448385015301 catalytic site [active] 448385015302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385015303 active site 448385015304 Double zinc ribbon; Region: DZR; pfam12773 448385015305 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385015306 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015307 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015308 active site 448385015309 ATP binding site [chemical binding]; other site 448385015310 substrate binding site [chemical binding]; other site 448385015311 activation loop (A-loop); other site 448385015312 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015313 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015314 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385015315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 448385015316 Walker A/P-loop; other site 448385015317 ATP binding site [chemical binding]; other site 448385015318 Q-loop/lid; other site 448385015319 ABC transporter signature motif; other site 448385015320 Walker B; other site 448385015321 D-loop; other site 448385015322 H-loop/switch region; other site 448385015323 Family description; Region: VCBS; pfam13517 448385015324 Family description; Region: VCBS; pfam13517 448385015325 CARDB; Region: CARDB; pfam07705 448385015326 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 448385015327 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015328 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015329 ABC transporter; Region: ABC_tran_2; pfam12848 448385015330 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385015332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385015333 TM-ABC transporter signature motif; other site 448385015334 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385015335 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385015336 Walker A/P-loop; other site 448385015337 ATP binding site [chemical binding]; other site 448385015338 Q-loop/lid; other site 448385015339 ABC transporter signature motif; other site 448385015340 Walker B; other site 448385015341 D-loop; other site 448385015342 H-loop/switch region; other site 448385015343 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385015344 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 448385015345 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385015346 NAD binding site [chemical binding]; other site 448385015347 catalytic Zn binding site [ion binding]; other site 448385015348 structural Zn binding site [ion binding]; other site 448385015349 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 448385015350 DNA polymerase II; Reviewed; Region: PRK05762 448385015351 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 448385015352 active site 448385015353 catalytic site [active] 448385015354 substrate binding site [chemical binding]; other site 448385015355 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 448385015356 active site 448385015357 metal-binding site 448385015358 phosphoglucomutase; Validated; Region: PRK07564 448385015359 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 448385015360 active site 448385015361 substrate binding site [chemical binding]; other site 448385015362 metal binding site [ion binding]; metal-binding site 448385015363 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 448385015364 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 448385015365 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385015366 Protein kinase domain; Region: Pkinase; pfam00069 448385015367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015368 active site 448385015369 ATP binding site [chemical binding]; other site 448385015370 substrate binding site [chemical binding]; other site 448385015371 activation loop (A-loop); other site 448385015372 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015373 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015374 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 448385015375 active site 448385015376 nucleophile elbow; other site 448385015377 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 448385015378 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 448385015379 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385015380 active site 448385015381 metal binding site [ion binding]; metal-binding site 448385015382 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 448385015383 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385015384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385015385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385015386 DNA binding residues [nucleotide binding] 448385015387 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 448385015388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385015389 motif II; other site 448385015390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385015391 dimer interface [polypeptide binding]; other site 448385015392 conserved gate region; other site 448385015393 putative PBP binding loops; other site 448385015394 ABC-ATPase subunit interface; other site 448385015395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 448385015396 NMT1/THI5 like; Region: NMT1; pfam09084 448385015397 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015398 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015399 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015400 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015401 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015402 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015403 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015404 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015405 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015406 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015407 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385015408 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 448385015409 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 448385015410 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 448385015411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385015412 putative active site [active] 448385015413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385015414 putative active site [active] 448385015415 heme pocket [chemical binding]; other site 448385015416 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385015417 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 448385015418 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 448385015419 HsdM N-terminal domain; Region: HsdM_N; pfam12161 448385015420 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385015421 S-adenosylmethionine binding site [chemical binding]; other site 448385015422 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 448385015423 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 448385015424 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 448385015425 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385015426 B12 binding site [chemical binding]; other site 448385015427 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385015428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385015429 FeS/SAM binding site; other site 448385015430 Cytochrome P450; Region: p450; cl12078 448385015431 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385015432 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 448385015433 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385015434 ATP binding site [chemical binding]; other site 448385015435 putative Mg++ binding site [ion binding]; other site 448385015436 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385015437 nucleotide binding region [chemical binding]; other site 448385015438 ATP-binding site [chemical binding]; other site 448385015439 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385015440 translocation protein TolB; Provisional; Region: tolB; PRK00178 448385015441 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015443 active site 448385015444 ATP binding site [chemical binding]; other site 448385015445 substrate binding site [chemical binding]; other site 448385015446 activation loop (A-loop); other site 448385015447 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385015448 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015449 active site 448385015450 ATP binding site [chemical binding]; other site 448385015451 substrate binding site [chemical binding]; other site 448385015452 activation loop (A-loop); other site 448385015453 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 448385015454 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385015455 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015456 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015457 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015458 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385015459 Putative transposase; Region: Y2_Tnp; pfam04986 448385015460 Putative transposase; Region: Y2_Tnp; pfam04986 448385015461 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 448385015462 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385015463 putative active site [active] 448385015464 putative NTP binding site [chemical binding]; other site 448385015465 putative nucleic acid binding site [nucleotide binding]; other site 448385015466 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 448385015467 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 448385015468 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385015469 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 448385015470 DNA binding residues [nucleotide binding] 448385015471 Ferredoxin [Energy production and conversion]; Region: COG1146 448385015472 4Fe-4S binding domain; Region: Fer4; cl02805 448385015473 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385015474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015475 Walker A motif; other site 448385015476 ATP binding site [chemical binding]; other site 448385015477 Walker B motif; other site 448385015478 arginine finger; other site 448385015479 Cellulose binding domain; Region: CBM_2; pfam00553 448385015480 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 448385015481 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 448385015482 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385015483 putative active site [active] 448385015484 putative active site [active] 448385015485 catalytic site [active] 448385015486 catalytic site [active] 448385015487 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 448385015488 PLD-like domain; Region: PLDc_2; pfam13091 448385015489 putative active site [active] 448385015490 catalytic site [active] 448385015491 diaminopimelate decarboxylase; Region: lysA; TIGR01048 448385015492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 448385015493 active site 448385015494 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 448385015495 substrate binding site [chemical binding]; other site 448385015496 catalytic residues [active] 448385015497 dimer interface [polypeptide binding]; other site 448385015498 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 448385015499 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 448385015500 CAAX protease self-immunity; Region: Abi; pfam02517 448385015501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385015502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385015503 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 448385015504 Winged helix-turn helix; Region: HTH_29; pfam13551 448385015505 Homeodomain-like domain; Region: HTH_32; pfam13565 448385015506 Integrase core domain; Region: rve; pfam00665 448385015507 Integrase core domain; Region: rve_3; cl15866 448385015508 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385015509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385015510 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385015511 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385015512 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385015513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385015514 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 448385015515 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 448385015516 active site 448385015517 non-prolyl cis peptide bond; other site 448385015518 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385015519 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 448385015520 Response regulator receiver domain; Region: Response_reg; pfam00072 448385015521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385015522 active site 448385015523 phosphorylation site [posttranslational modification] 448385015524 intermolecular recognition site; other site 448385015525 dimerization interface [polypeptide binding]; other site 448385015526 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385015527 two component system sensor kinase SsrA; Provisional; Region: PRK15347 448385015528 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385015529 dimerization interface [polypeptide binding]; other site 448385015530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385015531 dimer interface [polypeptide binding]; other site 448385015532 phosphorylation site [posttranslational modification] 448385015533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385015534 ATP binding site [chemical binding]; other site 448385015535 Mg2+ binding site [ion binding]; other site 448385015536 G-X-G motif; other site 448385015537 Response regulator receiver domain; Region: Response_reg; pfam00072 448385015538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385015539 active site 448385015540 phosphorylation site [posttranslational modification] 448385015541 intermolecular recognition site; other site 448385015542 dimerization interface [polypeptide binding]; other site 448385015543 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 448385015544 ABC-2 type transporter; Region: ABC2_membrane; cl17235 448385015545 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 448385015546 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385015547 Walker A/P-loop; other site 448385015548 ATP binding site [chemical binding]; other site 448385015549 Q-loop/lid; other site 448385015550 ABC transporter signature motif; other site 448385015551 Walker B; other site 448385015552 D-loop; other site 448385015553 H-loop/switch region; other site 448385015554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015556 active site 448385015557 ATP binding site [chemical binding]; other site 448385015558 substrate binding site [chemical binding]; other site 448385015559 activation loop (A-loop); other site 448385015560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385015561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 448385015562 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 448385015563 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 448385015564 putative ligand binding site [chemical binding]; other site 448385015565 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 448385015566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385015567 TM-ABC transporter signature motif; other site 448385015568 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 448385015569 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 448385015570 TM-ABC transporter signature motif; other site 448385015571 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 448385015572 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 448385015573 Walker A/P-loop; other site 448385015574 ATP binding site [chemical binding]; other site 448385015575 Q-loop/lid; other site 448385015576 ABC transporter signature motif; other site 448385015577 Walker B; other site 448385015578 D-loop; other site 448385015579 H-loop/switch region; other site 448385015580 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 448385015581 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 448385015582 Walker A/P-loop; other site 448385015583 ATP binding site [chemical binding]; other site 448385015584 Q-loop/lid; other site 448385015585 ABC transporter signature motif; other site 448385015586 Walker B; other site 448385015587 D-loop; other site 448385015588 H-loop/switch region; other site 448385015589 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015590 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015593 active site 448385015594 ATP binding site [chemical binding]; other site 448385015595 substrate binding site [chemical binding]; other site 448385015596 activation loop (A-loop); other site 448385015597 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015598 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015599 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015600 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015601 active site 448385015602 ATP binding site [chemical binding]; other site 448385015603 substrate binding site [chemical binding]; other site 448385015604 activation loop (A-loop); other site 448385015605 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015606 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015607 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 448385015608 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385015609 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385015610 PQQ-like domain; Region: PQQ_2; pfam13360 448385015611 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 448385015612 30S subunit binding site; other site 448385015613 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 448385015614 DNA-binding site [nucleotide binding]; DNA binding site 448385015615 RNA-binding motif; other site 448385015616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015618 active site 448385015619 ATP binding site [chemical binding]; other site 448385015620 substrate binding site [chemical binding]; other site 448385015621 activation loop (A-loop); other site 448385015622 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385015623 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385015624 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385015625 active site 448385015626 TROVE domain; Region: TROVE; pfam05731 448385015627 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385015628 malate dehydrogenase; Provisional; Region: PRK13529 448385015629 Malic enzyme, N-terminal domain; Region: malic; pfam00390 448385015630 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 448385015631 NAD(P) binding site [chemical binding]; other site 448385015632 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 448385015633 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 448385015634 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 448385015635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 448385015636 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 448385015637 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 448385015638 active site residue [active] 448385015639 Sulphur transport; Region: Sulf_transp; pfam04143 448385015640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385015641 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 448385015642 Low molecular weight phosphatase family; Region: LMWPc; cd00115 448385015643 active site 448385015644 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 448385015645 Asn-Pro-Ala signature motifs; other site 448385015646 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 448385015647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385015648 putative metal binding site [ion binding]; other site 448385015649 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385015650 putative DNA binding site [nucleotide binding]; other site 448385015651 putative Zn2+ binding site [ion binding]; other site 448385015652 CTP synthetase; Validated; Region: pyrG; PRK05380 448385015653 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 448385015654 Catalytic site [active] 448385015655 active site 448385015656 UTP binding site [chemical binding]; other site 448385015657 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 448385015658 active site 448385015659 putative oxyanion hole; other site 448385015660 catalytic triad [active] 448385015661 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385015662 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385015663 Phosphate transporter family; Region: PHO4; pfam01384 448385015664 Phosphate transporter family; Region: PHO4; pfam01384 448385015665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385015666 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385015667 FeS/SAM binding site; other site 448385015668 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385015669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385015670 S-adenosylmethionine binding site [chemical binding]; other site 448385015671 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385015672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385015673 S-adenosylmethionine binding site [chemical binding]; other site 448385015674 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385015675 Cytochrome P450; Region: p450; cl12078 448385015676 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385015677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385015678 S-adenosylmethionine binding site [chemical binding]; other site 448385015679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 448385015680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 448385015681 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 448385015682 AsnC family; Region: AsnC_trans_reg; pfam01037 448385015683 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 448385015684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385015685 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 448385015686 Patatin-like phospholipase; Region: Patatin; pfam01734 448385015687 active site 448385015688 nucleophile elbow; other site 448385015689 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 448385015690 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 448385015691 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 448385015692 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 448385015693 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 448385015694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015695 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015696 ABC transporter; Region: ABC_tran_2; pfam12848 448385015697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385015698 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 448385015699 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015700 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015701 active site 448385015702 ATP binding site [chemical binding]; other site 448385015703 substrate binding site [chemical binding]; other site 448385015704 activation loop (A-loop); other site 448385015705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385015706 TPR repeat; Region: TPR_11; pfam13414 448385015707 binding surface 448385015708 TPR motif; other site 448385015709 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385015710 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 448385015711 putative NAD(P) binding site [chemical binding]; other site 448385015712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385015713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385015714 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385015715 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385015716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385015717 Walker A/P-loop; other site 448385015718 ATP binding site [chemical binding]; other site 448385015719 Q-loop/lid; other site 448385015720 ABC transporter signature motif; other site 448385015721 Walker B; other site 448385015722 D-loop; other site 448385015723 H-loop/switch region; other site 448385015724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385015725 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 448385015726 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 448385015727 Walker A/P-loop; other site 448385015728 ATP binding site [chemical binding]; other site 448385015729 Q-loop/lid; other site 448385015730 ABC transporter signature motif; other site 448385015731 Walker B; other site 448385015732 D-loop; other site 448385015733 H-loop/switch region; other site 448385015734 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 448385015735 homotrimer interaction site [polypeptide binding]; other site 448385015736 putative active site [active] 448385015737 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385015738 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385015739 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 448385015740 putative effector binding pocket; other site 448385015741 putative dimerization interface [polypeptide binding]; other site 448385015742 aspartate aminotransferase; Provisional; Region: PRK05764 448385015743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385015744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385015745 homodimer interface [polypeptide binding]; other site 448385015746 catalytic residue [active] 448385015747 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 448385015748 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 448385015749 Protein of unknown function (DUF1810); Region: DUF1810; cl02370 448385015750 ZU5 domain; Region: ZU5; cl02517 448385015751 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 448385015752 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385015753 active site 448385015754 FG-GAP repeat; Region: FG-GAP; pfam01839 448385015755 Family description; Region: VCBS; pfam13517 448385015756 FG-GAP repeat; Region: FG-GAP; pfam01839 448385015757 FG-GAP repeat; Region: FG-GAP; cl15299 448385015758 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385015759 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385015760 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385015761 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015762 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015763 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385015764 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015765 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385015766 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385015767 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015768 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015769 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385015770 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385015771 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015772 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385015773 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015774 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015775 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385015776 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385015777 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385015778 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 448385015779 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385015780 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385015781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015783 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385015784 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 448385015785 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 448385015786 active site 448385015787 dimer interface [polypeptide binding]; other site 448385015788 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 448385015789 dimer interface [polypeptide binding]; other site 448385015790 active site 448385015791 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 448385015792 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 448385015793 TPP-binding site [chemical binding]; other site 448385015794 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 448385015795 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385015796 CoenzymeA binding site [chemical binding]; other site 448385015797 subunit interaction site [polypeptide binding]; other site 448385015798 PHB binding site; other site 448385015799 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 448385015800 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 448385015801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385015802 putative substrate translocation pore; other site 448385015803 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 448385015804 SIR2-like domain; Region: SIR2_2; pfam13289 448385015805 AAA domain; Region: AAA_23; pfam13476 448385015806 P-loop containing region of AAA domain; Region: AAA_29; cl17516 448385015807 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 448385015808 CRISPR-associated protein; Region: DUF3692; pfam12469 448385015809 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 448385015810 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 448385015811 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 448385015812 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 448385015813 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385015814 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385015815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015816 Walker A motif; other site 448385015817 ATP binding site [chemical binding]; other site 448385015818 Walker B motif; other site 448385015819 arginine finger; other site 448385015820 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 448385015821 active site 448385015822 NTP binding site [chemical binding]; other site 448385015823 metal binding triad [ion binding]; metal-binding site 448385015824 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385015825 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385015826 phosphopeptide binding site; other site 448385015827 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015829 active site 448385015830 ATP binding site [chemical binding]; other site 448385015831 substrate binding site [chemical binding]; other site 448385015832 activation loop (A-loop); other site 448385015833 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385015834 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385015835 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 448385015836 active site 448385015837 metal binding site [ion binding]; metal-binding site 448385015838 P-loop containing region of AAA domain; Region: AAA_29; cl17516 448385015839 cell division protein MukB; Provisional; Region: mukB; PRK04863 448385015840 condesin subunit E; Provisional; Region: PRK05256 448385015841 condesin subunit F; Provisional; Region: PRK05260 448385015842 Putative transposase; Region: Y2_Tnp; pfam04986 448385015843 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 448385015844 CotH protein; Region: CotH; pfam08757 448385015845 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 448385015846 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385015847 active site 448385015848 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 448385015849 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 448385015850 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 448385015851 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 448385015852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385015853 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385015854 Walker A motif; other site 448385015855 ATP binding site [chemical binding]; other site 448385015856 Walker B motif; other site 448385015857 arginine finger; other site 448385015858 TPR repeat; Region: TPR_11; pfam13414 448385015859 TPR repeat; Region: TPR_11; pfam13414 448385015860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385015861 TPR motif; other site 448385015862 binding surface 448385015863 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385015864 TPR motif; other site 448385015865 binding surface 448385015866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385015867 putative DNA binding site [nucleotide binding]; other site 448385015868 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385015869 putative hydrophobic ligand binding site [chemical binding]; other site 448385015870 YCII-related domain; Region: YCII; cl00999 448385015871 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 448385015872 active site 448385015873 catalytic triad [active] 448385015874 oxyanion hole [active] 448385015875 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 448385015876 dimer interface [polypeptide binding]; other site 448385015877 catalytic triad [active] 448385015878 peroxidatic and resolving cysteines [active] 448385015879 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385015880 Cytochrome P450; Region: p450; pfam00067 448385015881 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 448385015882 putative acyl-acceptor binding pocket; other site 448385015883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385015884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385015885 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 448385015886 active site 448385015887 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 448385015888 putative NAD(P) binding site [chemical binding]; other site 448385015889 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 448385015890 RibD C-terminal domain; Region: RibD_C; cl17279 448385015891 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 448385015892 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 448385015893 Protein of unknown function DUF72; Region: DUF72; cl00777 448385015894 Family description; Region: VCBS; pfam13517 448385015895 Family description; Region: VCBS; pfam13517 448385015896 Family description; Region: VCBS; pfam13517 448385015897 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 448385015898 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 448385015899 dimer interface [polypeptide binding]; other site 448385015900 acyl-activating enzyme (AAE) consensus motif; other site 448385015901 putative active site [active] 448385015902 AMP binding site [chemical binding]; other site 448385015903 putative CoA binding site [chemical binding]; other site 448385015904 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385015905 CoenzymeA binding site [chemical binding]; other site 448385015906 subunit interaction site [polypeptide binding]; other site 448385015907 PHB binding site; other site 448385015908 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 448385015909 catalytic residue [active] 448385015910 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 448385015911 PA14 domain; Region: PA14; cl08459 448385015912 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 448385015913 Peptidase family M28; Region: Peptidase_M28; pfam04389 448385015914 metal binding site [ion binding]; metal-binding site 448385015915 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 448385015916 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 448385015917 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 448385015918 EamA-like transporter family; Region: EamA; pfam00892 448385015919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 448385015920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 448385015921 DNA-binding site [nucleotide binding]; DNA binding site 448385015922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385015923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385015924 homodimer interface [polypeptide binding]; other site 448385015925 catalytic residue [active] 448385015926 Transcriptional regulator; Region: Rrf2; pfam02082 448385015927 Rrf2 family protein; Region: rrf2_super; TIGR00738 448385015928 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385015929 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385015930 catalytic residues [active] 448385015931 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385015932 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385015933 active site 448385015934 ATP binding site [chemical binding]; other site 448385015935 substrate binding site [chemical binding]; other site 448385015936 activation loop (A-loop); other site 448385015937 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 448385015938 ligand-binding site [chemical binding]; other site 448385015939 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 448385015940 ATP-sulfurylase; Region: ATPS; cd00517 448385015941 active site 448385015942 HXXH motif; other site 448385015943 flexible loop; other site 448385015944 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 448385015945 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385015946 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385015947 dimer interface [polypeptide binding]; other site 448385015948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385015949 catalytic residue [active] 448385015950 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 448385015951 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 448385015952 MoaE interaction surface [polypeptide binding]; other site 448385015953 MoeB interaction surface [polypeptide binding]; other site 448385015954 thiocarboxylated glycine; other site 448385015955 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 448385015956 ATP binding site [chemical binding]; other site 448385015957 substrate interface [chemical binding]; other site 448385015958 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385015959 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385015960 dimer interface [polypeptide binding]; other site 448385015961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385015962 catalytic residue [active] 448385015963 Rrf2 family protein; Region: rrf2_super; TIGR00738 448385015964 Transcriptional regulator; Region: Rrf2; pfam02082 448385015965 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385015966 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385015967 active site 448385015968 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 448385015969 Helix-turn-helix domain; Region: HTH_17; pfam12728 448385015970 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 448385015971 generic binding surface I; other site 448385015972 generic binding surface II; other site 448385015973 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 448385015974 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 448385015975 active site 448385015976 metal binding site [ion binding]; metal-binding site 448385015977 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 448385015978 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 448385015979 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 448385015980 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385015981 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 448385015982 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 448385015983 dimerization domain swap beta strand [polypeptide binding]; other site 448385015984 regulatory protein interface [polypeptide binding]; other site 448385015985 active site 448385015986 regulatory phosphorylation site [posttranslational modification]; other site 448385015987 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 448385015988 AAA domain; Region: AAA_18; pfam13238 448385015989 HPr kinase/phosphorylase; Provisional; Region: PRK05428 448385015990 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 448385015991 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 448385015992 Hpr binding site; other site 448385015993 active site 448385015994 homohexamer subunit interaction site [polypeptide binding]; other site 448385015995 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 448385015996 active site 448385015997 phosphorylation site [posttranslational modification] 448385015998 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 448385015999 30S subunit binding site; other site 448385016000 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 448385016001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016003 active site 448385016004 ATP binding site [chemical binding]; other site 448385016005 substrate binding site [chemical binding]; other site 448385016006 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016007 substrate binding site [chemical binding]; other site 448385016008 activation loop (A-loop); other site 448385016009 activation loop (A-loop); other site 448385016010 tartrate dehydrogenase; Region: TTC; TIGR02089 448385016011 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 448385016012 PAS domain S-box; Region: sensory_box; TIGR00229 448385016013 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 448385016014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385016015 dimer interface [polypeptide binding]; other site 448385016016 phosphorylation site [posttranslational modification] 448385016017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385016018 ATP binding site [chemical binding]; other site 448385016019 Mg2+ binding site [ion binding]; other site 448385016020 G-X-G motif; other site 448385016021 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 448385016022 putative active site pocket [active] 448385016023 dimerization interface [polypeptide binding]; other site 448385016024 putative catalytic residue [active] 448385016025 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 448385016026 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385016027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 448385016028 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 448385016029 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 448385016030 Predicted ATPase [General function prediction only]; Region: COG3899 448385016031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016032 TPR motif; other site 448385016033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016034 binding surface 448385016035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016037 TPR motif; other site 448385016038 binding surface 448385016039 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016042 binding surface 448385016043 TPR motif; other site 448385016044 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 448385016045 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 448385016046 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 448385016047 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 448385016048 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 448385016049 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 448385016050 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 448385016051 classical (c) SDRs; Region: SDR_c; cd05233 448385016052 NAD(P) binding site [chemical binding]; other site 448385016053 active site 448385016054 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 448385016055 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 448385016056 active site 448385016057 substrate binding site [chemical binding]; other site 448385016058 metal binding site [ion binding]; metal-binding site 448385016059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 448385016060 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385016061 Walker A/P-loop; other site 448385016062 ATP binding site [chemical binding]; other site 448385016063 Q-loop/lid; other site 448385016064 ABC transporter signature motif; other site 448385016065 Walker B; other site 448385016066 D-loop; other site 448385016067 H-loop/switch region; other site 448385016068 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385016069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016070 active site 448385016071 phosphorylation site [posttranslational modification] 448385016072 intermolecular recognition site; other site 448385016073 dimerization interface [polypeptide binding]; other site 448385016074 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016075 Walker A motif; other site 448385016076 ATP binding site [chemical binding]; other site 448385016077 Walker B motif; other site 448385016078 arginine finger; other site 448385016079 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385016080 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385016081 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385016082 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385016083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385016084 ligand binding site [chemical binding]; other site 448385016085 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 448385016086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385016087 active site 448385016088 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 448385016089 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 448385016090 Protein of unknown function (DUF503); Region: DUF503; pfam04456 448385016091 translation initiation factor IF-2; Region: IF-2; TIGR00487 448385016092 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 448385016093 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 448385016094 G1 box; other site 448385016095 putative GEF interaction site [polypeptide binding]; other site 448385016096 GTP/Mg2+ binding site [chemical binding]; other site 448385016097 Switch I region; other site 448385016098 G2 box; other site 448385016099 G3 box; other site 448385016100 Switch II region; other site 448385016101 G4 box; other site 448385016102 G5 box; other site 448385016103 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 448385016104 Translation-initiation factor 2; Region: IF-2; pfam11987 448385016105 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 448385016106 Protein of unknown function (DUF448); Region: DUF448; pfam04296 448385016107 putative RNA binding cleft [nucleotide binding]; other site 448385016108 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 448385016109 NusA N-terminal domain; Region: NusA_N; pfam08529 448385016110 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 448385016111 RNA binding site [nucleotide binding]; other site 448385016112 homodimer interface [polypeptide binding]; other site 448385016113 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 448385016114 G-X-X-G motif; other site 448385016115 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 448385016116 G-X-X-G motif; other site 448385016117 ribosome maturation protein RimP; Reviewed; Region: PRK00092 448385016118 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 448385016119 putative oligomer interface [polypeptide binding]; other site 448385016120 putative RNA binding site [nucleotide binding]; other site 448385016121 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 448385016122 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 448385016123 putative ligand binding site [chemical binding]; other site 448385016124 putative NAD binding site [chemical binding]; other site 448385016125 putative catalytic site [active] 448385016126 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 448385016127 Family description; Region: VCBS; pfam13517 448385016128 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 448385016129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016131 active site 448385016132 ATP binding site [chemical binding]; other site 448385016133 substrate binding site [chemical binding]; other site 448385016134 activation loop (A-loop); other site 448385016135 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385016136 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385016137 phosphopeptide binding site; other site 448385016138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016139 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016140 active site 448385016141 ATP binding site [chemical binding]; other site 448385016142 substrate binding site [chemical binding]; other site 448385016143 activation loop (A-loop); other site 448385016144 PEGA domain; Region: PEGA; pfam08308 448385016145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016146 TPR motif; other site 448385016147 TPR repeat; Region: TPR_11; pfam13414 448385016148 binding surface 448385016149 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 448385016150 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 448385016151 N-terminal plug; other site 448385016152 ligand-binding site [chemical binding]; other site 448385016153 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385016154 active site 448385016155 catalytic residues [active] 448385016156 Family description; Region: VCBS; pfam13517 448385016157 Family description; Region: VCBS; pfam13517 448385016158 FG-GAP repeat; Region: FG-GAP; cl15299 448385016159 Family description; Region: VCBS; pfam13517 448385016160 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385016161 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385016162 metal ion-dependent adhesion site (MIDAS); other site 448385016163 High-affinity nickel-transport protein; Region: NicO; cl00964 448385016164 Response regulator receiver domain; Region: Response_reg; pfam00072 448385016165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016166 active site 448385016167 phosphorylation site [posttranslational modification] 448385016168 intermolecular recognition site; other site 448385016169 dimerization interface [polypeptide binding]; other site 448385016170 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385016171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016172 active site 448385016173 phosphorylation site [posttranslational modification] 448385016174 intermolecular recognition site; other site 448385016175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385016176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385016177 ATP binding site [chemical binding]; other site 448385016178 Mg2+ binding site [ion binding]; other site 448385016179 G-X-G motif; other site 448385016180 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 448385016181 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 448385016182 Rab subfamily motif 1 (RabSF1); other site 448385016183 G1 box; other site 448385016184 GTP/Mg2+ binding site [chemical binding]; other site 448385016185 Rab subfamily motif 2 (RabSF2); other site 448385016186 Switch I region; other site 448385016187 G2 box; other site 448385016188 effector interaction site; other site 448385016189 GDI interaction site; other site 448385016190 Rab family motif 1 (RabF1); other site 448385016191 GEF interaction site [polypeptide binding]; other site 448385016192 Rab family motif 2 (RabF2); other site 448385016193 G3 box; other site 448385016194 Switch II region; other site 448385016195 Rab family motif 3 (RabF3); other site 448385016196 Rab family motif 4 (RabF4); other site 448385016197 Rab family motif 5 (RabF5); other site 448385016198 Rab subfamily motif 3 (RabSF3); other site 448385016199 G4 box; other site 448385016200 G5 box; other site 448385016201 Rab subfamily motif 4 (RabSF4); other site 448385016202 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385016203 ligand binding site [chemical binding]; other site 448385016204 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385016205 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 448385016206 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385016207 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385016208 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016210 active site 448385016211 ATP binding site [chemical binding]; other site 448385016212 substrate binding site [chemical binding]; other site 448385016213 activation loop (A-loop); other site 448385016214 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 448385016215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385016216 S-adenosylmethionine binding site [chemical binding]; other site 448385016217 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 448385016218 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 448385016219 active site 448385016220 dimer interface [polypeptide binding]; other site 448385016221 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 448385016222 Pectate lyase; Region: Pec_lyase_C; cl01593 448385016223 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385016224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016225 Walker A motif; other site 448385016226 ATP binding site [chemical binding]; other site 448385016227 Walker B motif; other site 448385016228 arginine finger; other site 448385016229 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385016230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016232 active site 448385016233 ATP binding site [chemical binding]; other site 448385016234 substrate binding site [chemical binding]; other site 448385016235 activation loop (A-loop); other site 448385016236 Response regulator receiver domain; Region: Response_reg; pfam00072 448385016237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016238 active site 448385016239 phosphorylation site [posttranslational modification] 448385016240 intermolecular recognition site; other site 448385016241 dimerization interface [polypeptide binding]; other site 448385016242 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385016243 cyclase homology domain; Region: CHD; cd07302 448385016244 nucleotidyl binding site; other site 448385016245 metal binding site [ion binding]; metal-binding site 448385016246 dimer interface [polypeptide binding]; other site 448385016247 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385016248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016249 active site 448385016250 ATP binding site [chemical binding]; other site 448385016251 substrate binding site [chemical binding]; other site 448385016252 activation loop (A-loop); other site 448385016253 Predicted ATPase [General function prediction only]; Region: COG3899 448385016254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016255 Walker A motif; other site 448385016256 ATP binding site [chemical binding]; other site 448385016257 Walker B motif; other site 448385016258 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385016259 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385016260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385016261 dimer interface [polypeptide binding]; other site 448385016262 phosphorylation site [posttranslational modification] 448385016263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385016264 ATP binding site [chemical binding]; other site 448385016265 Mg2+ binding site [ion binding]; other site 448385016266 G-X-G motif; other site 448385016267 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 448385016268 active site 448385016269 hydrophilic channel; other site 448385016270 dimerization interface [polypeptide binding]; other site 448385016271 catalytic residues [active] 448385016272 active site lid [active] 448385016273 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 448385016274 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 448385016275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385016276 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016277 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016278 active site 448385016279 ATP binding site [chemical binding]; other site 448385016280 substrate binding site [chemical binding]; other site 448385016281 activation loop (A-loop); other site 448385016282 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385016283 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385016284 active site 448385016285 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385016286 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385016287 Coenzyme A binding pocket [chemical binding]; other site 448385016288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385016289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385016290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385016291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385016292 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 448385016293 active site 448385016294 Zn binding site [ion binding]; other site 448385016295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385016296 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385016297 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385016298 ligand binding site [chemical binding]; other site 448385016299 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 448385016300 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 448385016301 Ligand Binding Site [chemical binding]; other site 448385016302 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 448385016303 chaperone protein DnaJ; Provisional; Region: PRK10767 448385016304 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385016305 HSP70 interaction site [polypeptide binding]; other site 448385016306 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 448385016307 substrate binding site [polypeptide binding]; other site 448385016308 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 448385016309 Zn binding sites [ion binding]; other site 448385016310 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 448385016311 dimer interface [polypeptide binding]; other site 448385016312 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 448385016313 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385016314 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 448385016315 acyl-activating enzyme (AAE) consensus motif; other site 448385016316 putative AMP binding site [chemical binding]; other site 448385016317 putative active site [active] 448385016318 putative CoA binding site [chemical binding]; other site 448385016319 PilZ domain; Region: PilZ; cl01260 448385016320 Hemerythrin-like domain; Region: Hr-like; cd12108 448385016321 PilZ domain; Region: PilZ; pfam07238 448385016322 FecR protein; Region: FecR; pfam04773 448385016323 RNA polymerase sigma factor; Provisional; Region: PRK12518 448385016324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385016326 DNA binding residues [nucleotide binding] 448385016327 purine nucleoside phosphorylase; Provisional; Region: PRK08202 448385016328 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 448385016329 active site 448385016330 catalytic motif [active] 448385016331 Zn binding site [ion binding]; other site 448385016332 Response regulator receiver domain; Region: Response_reg; pfam00072 448385016333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016334 active site 448385016335 phosphorylation site [posttranslational modification] 448385016336 intermolecular recognition site; other site 448385016337 dimerization interface [polypeptide binding]; other site 448385016338 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 448385016339 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 448385016340 active site 448385016341 ADP/pyrophosphate binding site [chemical binding]; other site 448385016342 dimerization interface [polypeptide binding]; other site 448385016343 allosteric effector site; other site 448385016344 fructose-1,6-bisphosphate binding site; other site 448385016345 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 448385016346 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 448385016347 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385016348 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385016349 protein binding site [polypeptide binding]; other site 448385016350 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385016351 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 448385016352 pyrroline-5-carboxylate reductase; Region: PLN02688 448385016353 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 448385016354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385016356 DNA binding residues [nucleotide binding] 448385016357 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 448385016358 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 448385016359 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 448385016360 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 448385016361 substrate binding pocket [chemical binding]; other site 448385016362 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 448385016363 B12 binding site [chemical binding]; other site 448385016364 cobalt ligand [ion binding]; other site 448385016365 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 448385016366 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385016367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385016368 S-adenosylmethionine binding site [chemical binding]; other site 448385016369 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 448385016370 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385016371 putative C-terminal domain interface [polypeptide binding]; other site 448385016372 putative GSH binding site (G-site) [chemical binding]; other site 448385016373 putative dimer interface [polypeptide binding]; other site 448385016374 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 448385016375 putative N-terminal domain interface [polypeptide binding]; other site 448385016376 putative dimer interface [polypeptide binding]; other site 448385016377 putative substrate binding pocket (H-site) [chemical binding]; other site 448385016378 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 448385016379 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 448385016380 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385016381 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 448385016382 allantoinase; Region: allantoinase; TIGR03178 448385016383 active site 448385016384 putative bifunctional allantoicase/OHCU decarboxylase; Provisional; Region: PRK13797 448385016385 Allantoicase repeat; Region: Allantoicase; pfam03561 448385016386 Allantoicase repeat; Region: Allantoicase; pfam03561 448385016387 putative OHCU decarboxylase; Provisional; Region: PRK13798 448385016388 CHRD domain; Region: CHRD; pfam07452 448385016389 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385016390 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385016391 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 448385016392 active site 448385016393 homotetramer interface [polypeptide binding]; other site 448385016394 PhoD-like phosphatase; Region: PhoD; pfam09423 448385016395 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 448385016396 putative active site [active] 448385016397 putative metal binding site [ion binding]; other site 448385016398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385016399 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 448385016400 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 448385016401 substrate binding site [chemical binding]; other site 448385016402 glutamase interaction surface [polypeptide binding]; other site 448385016403 tellurium resistance terB-like protein; Region: terB_like; cl11965 448385016404 metal binding site [ion binding]; metal-binding site 448385016405 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385016406 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385016407 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385016408 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 448385016409 Imelysin; Region: Peptidase_M75; pfam09375 448385016410 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385016411 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 448385016412 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385016413 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 448385016414 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 448385016415 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 448385016416 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385016417 catalytic loop [active] 448385016418 iron binding site [ion binding]; other site 448385016419 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 448385016420 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 448385016421 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 448385016422 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385016423 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 448385016424 active site 448385016425 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 448385016426 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 448385016427 XdhC Rossmann domain; Region: XdhC_C; pfam13478 448385016428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385016429 S-adenosylmethionine binding site [chemical binding]; other site 448385016430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016431 active site 448385016432 substrate binding site [chemical binding]; other site 448385016433 activation loop (A-loop); other site 448385016434 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016435 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 448385016436 Domain of unknown function DUF21; Region: DUF21; pfam01595 448385016437 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 448385016438 Transporter associated domain; Region: CorC_HlyC; smart01091 448385016439 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 448385016440 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385016441 metal ion-dependent adhesion site (MIDAS); other site 448385016442 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385016443 metal ion-dependent adhesion site (MIDAS); other site 448385016444 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385016445 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 448385016446 metal ion-dependent adhesion site (MIDAS); other site 448385016447 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385016448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016449 Walker A motif; other site 448385016450 ATP binding site [chemical binding]; other site 448385016451 Walker B motif; other site 448385016452 arginine finger; other site 448385016453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385016454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016455 active site 448385016456 phosphorylation site [posttranslational modification] 448385016457 intermolecular recognition site; other site 448385016458 dimerization interface [polypeptide binding]; other site 448385016459 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 448385016460 oligomerisation interface [polypeptide binding]; other site 448385016461 mobile loop; other site 448385016462 roof hairpin; other site 448385016463 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 448385016464 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 448385016465 ring oligomerisation interface [polypeptide binding]; other site 448385016466 ATP/Mg binding site [chemical binding]; other site 448385016467 stacking interactions; other site 448385016468 hinge regions; other site 448385016469 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385016470 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385016471 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 448385016472 C2 domain; Region: C2; cd00030 448385016473 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385016474 protein binding site [polypeptide binding]; other site 448385016475 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 448385016476 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100 448385016477 Dimer interface [polypeptide binding]; other site 448385016478 anticodon binding site; other site 448385016479 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 448385016480 homodimer interface [polypeptide binding]; other site 448385016481 motif 1; other site 448385016482 motif 2; other site 448385016483 active site 448385016484 motif 3; other site 448385016485 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 448385016486 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 448385016487 active site 448385016488 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 448385016489 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 448385016490 active site 448385016491 nucleophile elbow; other site 448385016492 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385016493 active site 448385016494 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385016495 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 448385016496 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 448385016497 dimer interface [polypeptide binding]; other site 448385016498 active site 448385016499 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385016500 active site 448385016501 Phosphopantetheine attachment site; Region: PP-binding; cl09936 448385016502 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385016503 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 448385016504 substrate binding site [chemical binding]; other site 448385016505 oxyanion hole (OAH) forming residues; other site 448385016506 trimer interface [polypeptide binding]; other site 448385016507 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385016508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016509 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385016510 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 448385016511 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385016512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016513 Walker A motif; other site 448385016514 ATP binding site [chemical binding]; other site 448385016515 Walker B motif; other site 448385016516 arginine finger; other site 448385016517 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 448385016518 catalytic core [active] 448385016519 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385016520 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385016521 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 448385016522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385016523 RNA binding surface [nucleotide binding]; other site 448385016524 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385016525 active site 448385016526 Maf-like protein; Region: Maf; pfam02545 448385016527 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 448385016528 active site 448385016529 dimer interface [polypeptide binding]; other site 448385016530 OmpA family; Region: OmpA; pfam00691 448385016531 ligand binding site [chemical binding]; other site 448385016532 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 448385016533 trimer interface [polypeptide binding]; other site 448385016534 putative Zn binding site [ion binding]; other site 448385016535 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 448385016536 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 448385016537 SLBB domain; Region: SLBB; pfam10531 448385016538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016539 binding surface 448385016540 TPR motif; other site 448385016541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016543 binding surface 448385016544 TPR motif; other site 448385016545 TPR repeat; Region: TPR_11; pfam13414 448385016546 TPR repeat; Region: TPR_11; pfam13414 448385016547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016548 TPR motif; other site 448385016549 binding surface 448385016550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016551 binding surface 448385016552 TPR motif; other site 448385016553 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016554 RNA polymerase sigma factor; Provisional; Region: PRK12513 448385016555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385016557 DNA binding residues [nucleotide binding] 448385016558 Putative zinc-finger; Region: zf-HC2; pfam13490 448385016559 PilZ domain; Region: PilZ; cl01260 448385016560 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 448385016561 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 448385016562 GTPase Era; Reviewed; Region: era; PRK00089 448385016563 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 448385016564 G1 box; other site 448385016565 GTP/Mg2+ binding site [chemical binding]; other site 448385016566 Switch I region; other site 448385016567 G2 box; other site 448385016568 Switch II region; other site 448385016569 G3 box; other site 448385016570 G4 box; other site 448385016571 G5 box; other site 448385016572 KH domain; Region: KH_2; pfam07650 448385016573 GTP-binding protein Der; Reviewed; Region: PRK00093 448385016574 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 448385016575 G1 box; other site 448385016576 GTP/Mg2+ binding site [chemical binding]; other site 448385016577 Switch I region; other site 448385016578 G2 box; other site 448385016579 Switch II region; other site 448385016580 G3 box; other site 448385016581 G4 box; other site 448385016582 G5 box; other site 448385016583 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 448385016584 G1 box; other site 448385016585 GTP/Mg2+ binding site [chemical binding]; other site 448385016586 Switch I region; other site 448385016587 G2 box; other site 448385016588 G3 box; other site 448385016589 Switch II region; other site 448385016590 G4 box; other site 448385016591 G5 box; other site 448385016592 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 448385016593 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 448385016594 DTAP/Switch II; other site 448385016595 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385016596 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 448385016597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385016598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385016599 Family description; Region: UvrD_C_2; pfam13538 448385016600 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016601 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016602 active site 448385016603 ATP binding site [chemical binding]; other site 448385016604 substrate binding site [chemical binding]; other site 448385016605 activation loop (A-loop); other site 448385016606 recombinase A; Provisional; Region: recA; PRK09354 448385016607 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 448385016608 hexamer interface [polypeptide binding]; other site 448385016609 Walker A motif; other site 448385016610 ATP binding site [chemical binding]; other site 448385016611 Walker B motif; other site 448385016612 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 448385016613 catalytic core [active] 448385016614 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 448385016615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385016616 Zn2+ binding site [ion binding]; other site 448385016617 Mg2+ binding site [ion binding]; other site 448385016618 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016620 active site 448385016621 ATP binding site [chemical binding]; other site 448385016622 substrate binding site [chemical binding]; other site 448385016623 activation loop (A-loop); other site 448385016624 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 448385016625 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 448385016626 catalytic triad [active] 448385016627 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385016628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385016629 active site 448385016630 metal binding site [ion binding]; metal-binding site 448385016631 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385016632 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 448385016633 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385016634 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385016635 active site 448385016636 metal binding site [ion binding]; metal-binding site 448385016637 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 448385016638 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 448385016639 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 448385016640 NAD(P) binding site [chemical binding]; other site 448385016641 catalytic residues [active] 448385016642 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 448385016643 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 448385016644 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385016645 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385016646 GAF domain; Region: GAF; pfam01590 448385016647 GAF domain; Region: GAF_2; pfam13185 448385016648 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385016649 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 448385016650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385016651 maleylacetoacetate isomerase; Region: maiA; TIGR01262 448385016652 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 448385016653 C-terminal domain interface [polypeptide binding]; other site 448385016654 GSH binding site (G-site) [chemical binding]; other site 448385016655 putative dimer interface [polypeptide binding]; other site 448385016656 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 448385016657 dimer interface [polypeptide binding]; other site 448385016658 N-terminal domain interface [polypeptide binding]; other site 448385016659 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 448385016660 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 448385016661 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 448385016662 dimer interface [polypeptide binding]; other site 448385016663 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 448385016664 active site 448385016665 Fe binding site [ion binding]; other site 448385016666 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 448385016667 Deoxyhypusine synthase; Region: DS; cl00826 448385016668 deoxyhypusine synthase; Region: dhys; TIGR00321 448385016669 Protein of unknown function DUF72; Region: DUF72; pfam01904 448385016670 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 448385016671 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 448385016672 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 448385016673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016675 active site 448385016676 ATP binding site [chemical binding]; other site 448385016677 substrate binding site [chemical binding]; other site 448385016678 activation loop (A-loop); other site 448385016679 AAA ATPase domain; Region: AAA_16; pfam13191 448385016680 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385016681 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385016682 structural tetrad; other site 448385016683 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385016684 structural tetrad; other site 448385016685 GAF domain; Region: GAF; pfam01590 448385016686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016687 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385016688 Walker A motif; other site 448385016689 ATP binding site [chemical binding]; other site 448385016690 Walker B motif; other site 448385016691 arginine finger; other site 448385016692 Response regulator receiver domain; Region: Response_reg; pfam00072 448385016693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016694 active site 448385016695 phosphorylation site [posttranslational modification] 448385016696 intermolecular recognition site; other site 448385016697 dimerization interface [polypeptide binding]; other site 448385016698 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 448385016699 putative dimer interface [polypeptide binding]; other site 448385016700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385016701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385016702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385016703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385016704 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 448385016705 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 448385016706 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 448385016707 Amidase; Region: Amidase; cl11426 448385016708 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016709 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016710 active site 448385016711 ATP binding site [chemical binding]; other site 448385016712 substrate binding site [chemical binding]; other site 448385016713 activation loop (A-loop); other site 448385016714 Predicted ATPase [General function prediction only]; Region: COG3899 448385016715 AAA ATPase domain; Region: AAA_16; pfam13191 448385016716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385016717 binding surface 448385016718 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385016719 TPR motif; other site 448385016720 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385016721 Predicted transcriptional regulators [Transcription]; Region: COG1695 448385016722 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 448385016723 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 448385016724 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 448385016725 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 448385016726 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385016727 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 448385016728 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 448385016729 putative ligand binding site [chemical binding]; other site 448385016730 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385016731 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385016732 Multicopper oxidase; Region: Cu-oxidase; pfam00394 448385016733 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385016734 Phosphotransferase enzyme family; Region: APH; pfam01636 448385016735 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385016736 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 448385016737 active site 448385016738 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 448385016739 heme-binding site [chemical binding]; other site 448385016740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385016741 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385016742 putative active site [active] 448385016743 heme pocket [chemical binding]; other site 448385016744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385016745 phosphorylation site [posttranslational modification] 448385016746 dimer interface [polypeptide binding]; other site 448385016747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385016748 ATP binding site [chemical binding]; other site 448385016749 Mg2+ binding site [ion binding]; other site 448385016750 G-X-G motif; other site 448385016751 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385016752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016753 active site 448385016754 phosphorylation site [posttranslational modification] 448385016755 intermolecular recognition site; other site 448385016756 dimerization interface [polypeptide binding]; other site 448385016757 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385016758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385016759 active site 448385016760 phosphorylation site [posttranslational modification] 448385016761 intermolecular recognition site; other site 448385016762 dimerization interface [polypeptide binding]; other site 448385016763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385016764 Walker A motif; other site 448385016765 ATP binding site [chemical binding]; other site 448385016766 Walker B motif; other site 448385016767 arginine finger; other site 448385016768 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385016769 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 448385016770 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 448385016771 homodimer interface [polypeptide binding]; other site 448385016772 substrate-cofactor binding pocket; other site 448385016773 catalytic residue [active] 448385016774 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 448385016775 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016776 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016777 active site 448385016778 ATP binding site [chemical binding]; other site 448385016779 substrate binding site [chemical binding]; other site 448385016780 activation loop (A-loop); other site 448385016781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385016782 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385016783 Amidohydrolase; Region: Amidohydro_4; pfam13147 448385016784 active site 448385016785 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 448385016786 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 448385016787 YcaO-like family; Region: YcaO; pfam02624 448385016788 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 448385016789 putative FMN binding site [chemical binding]; other site 448385016790 NADPH bind site [chemical binding]; other site 448385016791 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 448385016792 PA/protease or protease-like domain interface [polypeptide binding]; other site 448385016793 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 448385016794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016795 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016796 active site 448385016797 ATP binding site [chemical binding]; other site 448385016798 substrate binding site [chemical binding]; other site 448385016799 activation loop (A-loop); other site 448385016800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385016801 binding surface 448385016802 TPR motif; other site 448385016803 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385016804 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385016805 ligand binding site [chemical binding]; other site 448385016806 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 448385016807 Zn binding site [ion binding]; other site 448385016808 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 448385016809 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 448385016810 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 448385016811 nucleotide binding site [chemical binding]; other site 448385016812 Hexokinase; Region: Hexokinase_2; pfam03727 448385016813 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 448385016814 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 448385016815 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 448385016816 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016817 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016818 active site 448385016819 ATP binding site [chemical binding]; other site 448385016820 substrate binding site [chemical binding]; other site 448385016821 activation loop (A-loop); other site 448385016822 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 448385016823 ArsC family; Region: ArsC; pfam03960 448385016824 putative ArsC-like catalytic residues; other site 448385016825 putative TRX-like catalytic residues [active] 448385016826 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 448385016827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385016828 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385016829 ABC transporter; Region: ABC_tran_2; pfam12848 448385016830 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385016831 GAF domain; Region: GAF_3; pfam13492 448385016832 GAF domain; Region: GAF_2; pfam13185 448385016833 PAS domain; Region: PAS_9; pfam13426 448385016834 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385016835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385016836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385016837 dimer interface [polypeptide binding]; other site 448385016838 phosphorylation site [posttranslational modification] 448385016839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385016840 ATP binding site [chemical binding]; other site 448385016841 Mg2+ binding site [ion binding]; other site 448385016842 G-X-G motif; other site 448385016843 Kelch domain; Region: Kelch; smart00612 448385016844 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385016845 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385016846 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385016847 Kelch domain; Region: Kelch; smart00612 448385016848 PEGA domain; Region: PEGA; pfam08308 448385016849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385016850 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385016851 active site 448385016852 ATP binding site [chemical binding]; other site 448385016853 substrate binding site [chemical binding]; other site 448385016854 activation loop (A-loop); other site 448385016855 hypothetical protein; Provisional; Region: PRK05409 448385016856 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 448385016857 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385016858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385016860 DNA binding residues [nucleotide binding] 448385016861 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 448385016862 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 448385016863 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 448385016864 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 448385016865 putative dimer interface [polypeptide binding]; other site 448385016866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385016867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385016868 dimerization interface [polypeptide binding]; other site 448385016869 putative DNA binding site [nucleotide binding]; other site 448385016870 putative Zn2+ binding site [ion binding]; other site 448385016871 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 448385016872 putative hydrophobic ligand binding site [chemical binding]; other site 448385016873 AAA domain; Region: AAA_33; pfam13671 448385016874 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 448385016875 Uncharacterized conserved protein [Function unknown]; Region: COG4021 448385016876 Thg1 C terminal domain; Region: Thg1C; pfam14413 448385016877 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 448385016878 HD domain; Region: HD_4; pfam13328 448385016879 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 448385016880 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385016881 active site 448385016882 ATP binding site [chemical binding]; other site 448385016883 substrate binding site [chemical binding]; other site 448385016884 activation loop (A-loop); other site 448385016885 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385016886 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385016887 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385016888 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 448385016889 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385016890 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 448385016891 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385016892 putative catalytic residue [active] 448385016893 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 448385016894 active site 448385016895 HEAT repeats; Region: HEAT_2; pfam13646 448385016896 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 448385016897 TIGR01777 family protein; Region: yfcH 448385016898 putative NAD(P) binding site [chemical binding]; other site 448385016899 putative active site [active] 448385016900 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 448385016901 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385016902 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385016903 Di-iron ligands [ion binding]; other site 448385016904 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385016905 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 448385016906 active site 448385016907 metal-binding site 448385016908 D-cysteine desulfhydrase; Validated; Region: PRK03910 448385016909 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 448385016910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385016911 catalytic residue [active] 448385016912 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 448385016913 active sites [active] 448385016914 tetramer interface [polypeptide binding]; other site 448385016915 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385016916 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 448385016917 active site 448385016918 catalytic residues [active] 448385016919 DNA binding site [nucleotide binding] 448385016920 Int/Topo IB signature motif; other site 448385016921 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385016922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385016923 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385016924 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385016925 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 448385016926 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 448385016927 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 448385016928 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385016929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016930 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385016931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016932 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385016933 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385016934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 448385016935 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 448385016936 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016937 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385016938 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385016939 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385016940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016941 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385016942 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385016943 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385016944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016945 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385016946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016947 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385016948 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385016949 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385016950 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016951 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385016952 Winged helix-turn helix; Region: HTH_29; pfam13551 448385016953 Homeodomain-like domain; Region: HTH_32; pfam13565 448385016954 Integrase core domain; Region: rve; pfam00665 448385016955 DDE domain; Region: DDE_Tnp_IS240; pfam13610 448385016956 Integrase core domain; Region: rve_3; pfam13683 448385016957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385016958 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 448385016959 DNA binding site [nucleotide binding] 448385016960 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385016961 active site 448385016962 Int/Topo IB signature motif; other site 448385016963 Predicted membrane protein [Function unknown]; Region: COG2311 448385016964 Protein of unknown function (DUF418); Region: DUF418; cl12135 448385016965 Protein of unknown function (DUF418); Region: DUF418; pfam04235 448385016966 Helix-turn-helix domain; Region: HTH_38; pfam13936 448385016967 Helix-turn-helix domain of alkylmercury lyase; Region: HTH_15; pfam12324 448385016968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385016969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385016970 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385016971 putative effector binding pocket; other site 448385016972 dimerization interface [polypeptide binding]; other site 448385016973 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 448385016974 putative catalytic residues [active] 448385016975 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385016976 Predicted ATPase [General function prediction only]; Region: COG4637 448385016977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385016978 Walker A/P-loop; other site 448385016979 ATP binding site [chemical binding]; other site 448385016980 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385016981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385016982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385016983 DNA binding residues [nucleotide binding] 448385016984 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385016985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016986 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385016987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385016988 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385016989 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385016990 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 448385016991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385016992 Helix-turn-helix domain; Region: HTH_28; pfam13518 448385016993 Winged helix-turn helix; Region: HTH_29; pfam13551 448385016994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385016995 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 448385016996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385016997 DNA binding residues [nucleotide binding] 448385016998 dimerization interface [polypeptide binding]; other site 448385016999 HerA helicase [Replication, recombination, and repair]; Region: COG0433 448385017000 Domain of unknown function (DUF955); Region: DUF955; cl01076 448385017001 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385017002 EcsC protein family; Region: EcsC; pfam12787 448385017003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385017004 dimer interface [polypeptide binding]; other site 448385017005 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 448385017006 phosphorylation site [posttranslational modification] 448385017007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385017008 ATP binding site [chemical binding]; other site 448385017009 G-X-G motif; other site 448385017010 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 448385017011 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 448385017012 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 448385017013 N-acetyl-D-glucosamine binding site [chemical binding]; other site 448385017014 catalytic residue [active] 448385017015 AAA domain; Region: AAA_23; pfam13476 448385017016 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 448385017017 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 448385017018 active site 448385017019 Zn binding site [ion binding]; other site 448385017020 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385017021 putative active site [active] 448385017022 Response regulator receiver domain; Region: Response_reg; pfam00072 448385017023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385017024 active site 448385017025 phosphorylation site [posttranslational modification] 448385017026 intermolecular recognition site; other site 448385017027 dimerization interface [polypeptide binding]; other site 448385017028 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 448385017029 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385017030 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017031 active site 448385017032 ATP binding site [chemical binding]; other site 448385017033 substrate binding site [chemical binding]; other site 448385017034 activation loop (A-loop); other site 448385017035 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 448385017036 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 448385017037 homodimer interface [polypeptide binding]; other site 448385017038 substrate-cofactor binding pocket; other site 448385017039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385017040 catalytic residue [active] 448385017041 Protein phosphatase 2C; Region: PP2C; pfam00481 448385017042 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385017043 active site 448385017044 ribosome recycling factor; Reviewed; Region: frr; PRK00083 448385017045 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 448385017046 hinge region; other site 448385017047 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385017048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385017049 active site 448385017050 phosphorylation site [posttranslational modification] 448385017051 intermolecular recognition site; other site 448385017052 dimerization interface [polypeptide binding]; other site 448385017053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017054 Walker A motif; other site 448385017055 ATP binding site [chemical binding]; other site 448385017056 Walker B motif; other site 448385017057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385017058 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 448385017059 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 448385017060 catalytic triad [active] 448385017061 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 448385017062 active site 448385017063 DNA binding site [nucleotide binding] 448385017064 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 448385017065 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 448385017066 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 448385017067 G1 box; other site 448385017068 putative GEF interaction site [polypeptide binding]; other site 448385017069 GTP/Mg2+ binding site [chemical binding]; other site 448385017070 Switch I region; other site 448385017071 G2 box; other site 448385017072 G3 box; other site 448385017073 Switch II region; other site 448385017074 G4 box; other site 448385017075 G5 box; other site 448385017076 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 448385017077 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 448385017078 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 448385017079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385017080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385017081 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385017082 substrate binding pocket [chemical binding]; other site 448385017083 dimerization interface [polypeptide binding]; other site 448385017084 AMIN domain; Region: AMIN; pfam11741 448385017085 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 448385017086 Secretin and TonB N terminus short domain; Region: STN; pfam07660 448385017087 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 448385017088 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 448385017089 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 448385017090 Pilus assembly protein, PilP; Region: PilP; pfam04351 448385017091 Pilus assembly protein, PilO; Region: PilO; cl01234 448385017092 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 448385017093 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 448385017094 Competence protein A; Region: Competence_A; pfam11104 448385017095 Cell division protein FtsA; Region: FtsA; pfam14450 448385017096 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 448385017097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385017098 Peptidase M15; Region: Peptidase_M15_3; cl01194 448385017099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 448385017100 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 448385017101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385017102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385017103 DNA binding residues [nucleotide binding] 448385017104 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 448385017105 active site 2 [active] 448385017106 active site 1 [active] 448385017107 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 448385017108 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 448385017109 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 448385017110 catalytic residue [active] 448385017111 putative FPP diphosphate binding site; other site 448385017112 putative FPP binding hydrophobic cleft; other site 448385017113 dimer interface [polypeptide binding]; other site 448385017114 putative IPP diphosphate binding site; other site 448385017115 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 448385017116 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 448385017117 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 448385017118 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 448385017119 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 448385017120 NAD(P) binding site [chemical binding]; other site 448385017121 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 448385017122 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 448385017123 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 448385017124 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 448385017125 putative active site [active] 448385017126 redox center [active] 448385017127 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385017128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 448385017129 ligand binding site [chemical binding]; other site 448385017130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385017131 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385017132 catalytic residues [active] 448385017133 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385017134 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 448385017135 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 448385017136 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 448385017137 DNA binding site [nucleotide binding] 448385017138 active site 448385017139 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 448385017140 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 448385017141 AlkA N-terminal domain; Region: AlkA_N; pfam06029 448385017142 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 448385017143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 448385017144 minor groove reading motif; other site 448385017145 helix-hairpin-helix signature motif; other site 448385017146 substrate binding pocket [chemical binding]; other site 448385017147 active site 448385017148 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 448385017149 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 448385017150 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 448385017151 NAD binding site [chemical binding]; other site 448385017152 Phe binding site; other site 448385017153 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 448385017154 Carbon starvation protein CstA; Region: CstA; pfam02554 448385017155 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 448385017156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385017157 classical (c) SDRs; Region: SDR_c; cd05233 448385017158 NAD(P) binding site [chemical binding]; other site 448385017159 active site 448385017160 DJ-1 family protein; Region: not_thiJ; TIGR01383 448385017161 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 448385017162 conserved cys residue [active] 448385017163 Protein kinase domain; Region: Pkinase; pfam00069 448385017164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017165 active site 448385017166 ATP binding site [chemical binding]; other site 448385017167 substrate binding site [chemical binding]; other site 448385017168 activation loop (A-loop); other site 448385017169 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385017170 Putative transposase; Region: Y2_Tnp; pfam04986 448385017171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017172 Q-loop/lid; other site 448385017173 ABC transporter signature motif; other site 448385017174 Walker B; other site 448385017175 D-loop; other site 448385017176 H-loop/switch region; other site 448385017177 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385017178 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385017179 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385017180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017181 Walker A motif; other site 448385017182 ATP binding site [chemical binding]; other site 448385017183 Walker B motif; other site 448385017184 arginine finger; other site 448385017185 SIR2-like domain; Region: SIR2_2; pfam13289 448385017186 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385017187 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385017188 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 448385017189 active site 448385017190 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385017191 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 448385017192 putative NAD(P) binding site [chemical binding]; other site 448385017193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385017194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017195 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385017196 hypothetical protein; Provisional; Region: PRK07758 448385017197 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385017198 Flagellin N-methylase; Region: FliB; pfam03692 448385017199 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 448385017200 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 448385017201 catalytic triad [active] 448385017202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385017203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385017204 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 448385017205 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 448385017206 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 448385017207 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 448385017208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 448385017209 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 448385017210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385017211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385017212 homodimer interface [polypeptide binding]; other site 448385017213 catalytic residue [active] 448385017214 Short C-terminal domain; Region: SHOCT; pfam09851 448385017215 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 448385017216 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385017217 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385017218 catalytic residues [active] 448385017219 aspartate kinase; Reviewed; Region: PRK06635 448385017220 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 448385017221 putative catalytic residues [active] 448385017222 putative nucleotide binding site [chemical binding]; other site 448385017223 putative aspartate binding site [chemical binding]; other site 448385017224 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 448385017225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385017226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385017227 phosphorylation site [posttranslational modification] 448385017228 dimer interface [polypeptide binding]; other site 448385017229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385017230 ATP binding site [chemical binding]; other site 448385017231 Mg2+ binding site [ion binding]; other site 448385017232 G-X-G motif; other site 448385017233 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 448385017234 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 448385017235 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 448385017236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017237 AAA domain; Region: AAA_21; pfam13304 448385017238 Walker A/P-loop; other site 448385017239 ATP binding site [chemical binding]; other site 448385017240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017241 Q-loop/lid; other site 448385017242 ABC transporter signature motif; other site 448385017243 Walker B; other site 448385017244 D-loop; other site 448385017245 H-loop/switch region; other site 448385017246 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 448385017247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385017248 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385017249 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385017250 ABC1 family; Region: ABC1; cl17513 448385017251 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 448385017252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017253 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017254 active site 448385017255 ATP binding site [chemical binding]; other site 448385017256 substrate binding site [chemical binding]; other site 448385017257 activation loop (A-loop); other site 448385017258 Predicted integral membrane protein [Function unknown]; Region: COG5616 448385017259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017260 TPR repeat; Region: TPR_11; pfam13414 448385017261 binding surface 448385017262 TPR motif; other site 448385017263 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 448385017264 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 448385017265 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 448385017266 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385017267 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385017268 phosphopeptide binding site; other site 448385017269 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385017270 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385017271 phosphopeptide binding site; other site 448385017272 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385017273 active site 448385017274 oxyanion hole [active] 448385017275 catalytic triad [active] 448385017276 TLC ATP/ADP transporter; Region: TLC; cl03940 448385017277 TLC ATP/ADP transporter; Region: TLC; cl03940 448385017278 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385017279 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 448385017280 PGAP1-like protein; Region: PGAP1; pfam07819 448385017281 oxidative damage protection protein; Provisional; Region: PRK05408 448385017282 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 448385017283 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 448385017284 active site 448385017285 catalytic residues [active] 448385017286 DNA binding site [nucleotide binding] 448385017287 Int/Topo IB signature motif; other site 448385017288 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385017289 sequence-specific DNA binding site [nucleotide binding]; other site 448385017290 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 448385017291 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 448385017292 catalytic residues [active] 448385017293 catalytic nucleophile [active] 448385017294 Recombinase; Region: Recombinase; pfam07508 448385017295 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 448385017296 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 448385017297 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385017298 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385017299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385017300 Winged helix-turn helix; Region: HTH_29; pfam13551 448385017301 Homeodomain-like domain; Region: HTH_32; pfam13565 448385017302 Integrase core domain; Region: rve; pfam00665 448385017303 DDE domain; Region: DDE_Tnp_IS240; pfam13610 448385017304 Integrase core domain; Region: rve_3; pfam13683 448385017305 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385017306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385017307 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385017308 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385017309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385017310 Putative transposase; Region: Y2_Tnp; pfam04986 448385017311 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 448385017312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017313 TPR motif; other site 448385017314 binding surface 448385017315 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385017316 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 448385017317 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 448385017318 conserved cys residue [active] 448385017319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017321 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 448385017322 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 448385017323 homotrimer interaction site [polypeptide binding]; other site 448385017324 putative active site [active] 448385017325 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 448385017326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385017327 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385017328 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385017329 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 448385017330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385017331 dimerization interface [polypeptide binding]; other site 448385017332 putative DNA binding site [nucleotide binding]; other site 448385017333 putative Zn2+ binding site [ion binding]; other site 448385017334 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 448385017335 putative hydrophobic ligand binding site [chemical binding]; other site 448385017336 DoxX-like family; Region: DoxX_2; pfam13564 448385017337 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 448385017338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017339 Walker A/P-loop; other site 448385017340 ATP binding site [chemical binding]; other site 448385017341 Q-loop/lid; other site 448385017342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017343 ABC transporter signature motif; other site 448385017344 Walker B; other site 448385017345 D-loop; other site 448385017346 H-loop/switch region; other site 448385017347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017348 Walker A/P-loop; other site 448385017349 ATP binding site [chemical binding]; other site 448385017350 ABC transporter signature motif; other site 448385017351 Walker B; other site 448385017352 D-loop; other site 448385017353 H-loop/switch region; other site 448385017354 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017355 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017356 active site 448385017357 ATP binding site [chemical binding]; other site 448385017358 substrate binding site [chemical binding]; other site 448385017359 activation loop (A-loop); other site 448385017360 AAA ATPase domain; Region: AAA_16; pfam13191 448385017361 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 448385017362 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 448385017363 metal binding site [ion binding]; metal-binding site 448385017364 putative dimer interface [polypeptide binding]; other site 448385017365 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 448385017366 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385017367 putative active site [active] 448385017368 putative NTP binding site [chemical binding]; other site 448385017369 putative nucleic acid binding site [nucleotide binding]; other site 448385017370 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 448385017371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 448385017372 PAS domain; Region: PAS_9; pfam13426 448385017373 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385017374 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385017375 Cytochrome P450; Region: p450; cl12078 448385017376 Activator of aromatic catabolism; Region: XylR_N; pfam06505 448385017377 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 448385017378 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385017379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017380 Walker A motif; other site 448385017381 ATP binding site [chemical binding]; other site 448385017382 Walker B motif; other site 448385017383 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385017384 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 448385017385 Predicted membrane protein [Function unknown]; Region: COG3817 448385017386 Protein of unknown function (DUF979); Region: DUF979; pfam06166 448385017387 Protein of unknown function (DUF969); Region: DUF969; pfam06149 448385017388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385017389 Coenzyme A binding pocket [chemical binding]; other site 448385017390 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385017391 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385017392 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 448385017393 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 448385017394 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385017395 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 448385017396 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 448385017397 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385017398 catalytic loop [active] 448385017399 iron binding site [ion binding]; other site 448385017400 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 448385017401 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017402 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017403 active site 448385017404 ATP binding site [chemical binding]; other site 448385017405 substrate binding site [chemical binding]; other site 448385017406 activation loop (A-loop); other site 448385017407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385017408 PEGA domain; Region: PEGA; pfam08308 448385017409 Putative transposase; Region: Y2_Tnp; pfam04986 448385017410 transposase; Validated; Region: PRK08181 448385017411 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385017412 PEGA domain; Region: PEGA; pfam08308 448385017413 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385017414 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385017415 Vitelline membrane outer layer protein I (VMO-I) domain, VMO-I is one of the proteins found in the outer layer of the vitelline membrane of poultry eggs; VMO-I, lysozyme, and VMO-II are tightly bound to ovomucin; this complex forms the backbone of the...; Region: VMO-I; cl00167 448385017416 putative carbohydrate binding site [chemical binding]; other site 448385017417 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385017418 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017419 active site 448385017420 ATP binding site [chemical binding]; other site 448385017421 substrate binding site [chemical binding]; other site 448385017422 activation loop (A-loop); other site 448385017423 AAA ATPase domain; Region: AAA_16; pfam13191 448385017424 Predicted ATPase [General function prediction only]; Region: COG3899 448385017425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385017426 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385017427 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385017428 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 448385017429 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385017430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385017431 active site 448385017432 phosphorylation site [posttranslational modification] 448385017433 intermolecular recognition site; other site 448385017434 dimerization interface [polypeptide binding]; other site 448385017435 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385017436 DNA binding site [nucleotide binding] 448385017437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385017438 HAMP domain; Region: HAMP; pfam00672 448385017439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385017440 dimer interface [polypeptide binding]; other site 448385017441 phosphorylation site [posttranslational modification] 448385017442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385017443 ATP binding site [chemical binding]; other site 448385017444 Mg2+ binding site [ion binding]; other site 448385017445 G-X-G motif; other site 448385017446 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385017447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385017448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017449 putative pectinesterase; Region: PLN02432; cl01911 448385017450 Right handed beta helix region; Region: Beta_helix; pfam13229 448385017451 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 448385017452 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 448385017453 active site 448385017454 non-prolyl cis peptide bond; other site 448385017455 Cupin; Region: Cupin_6; pfam12852 448385017456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385017457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017458 short chain dehydrogenase; Provisional; Region: PRK06523 448385017459 classical (c) SDRs; Region: SDR_c; cd05233 448385017460 NAD(P) binding site [chemical binding]; other site 448385017461 active site 448385017462 CARDB; Region: CARDB; pfam07705 448385017463 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385017464 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385017465 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 448385017466 substrate binding pocket [chemical binding]; other site 448385017467 substrate-Mg2+ binding site; other site 448385017468 aspartate-rich region 1; other site 448385017469 aspartate-rich region 2; other site 448385017470 Kelch motif; Region: Kelch_1; pfam01344 448385017471 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385017472 Kelch domain; Region: Kelch; smart00612 448385017473 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385017474 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385017475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385017476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017477 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 448385017478 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 448385017479 conserved cys residue [active] 448385017480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017481 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 448385017482 putative active site [active] 448385017483 putative substrate binding site [chemical binding]; other site 448385017484 putative cosubstrate binding site; other site 448385017485 catalytic site [active] 448385017486 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 448385017487 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 448385017488 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385017489 substrate binding site [chemical binding]; other site 448385017490 oxyanion hole (OAH) forming residues; other site 448385017491 trimer interface [polypeptide binding]; other site 448385017492 Predicted esterase [General function prediction only]; Region: COG0400 448385017493 Kelch motif; Region: Kelch_1; pfam01344 448385017494 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385017495 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385017496 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385017497 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385017498 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 448385017499 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385017500 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 448385017501 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385017502 NADH(P)-binding; Region: NAD_binding_10; pfam13460 448385017503 NAD(P) binding site [chemical binding]; other site 448385017504 active site 448385017505 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385017506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385017507 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385017508 substrate binding pocket [chemical binding]; other site 448385017509 dimerization interface [polypeptide binding]; other site 448385017510 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 448385017511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385017512 ATP binding site [chemical binding]; other site 448385017513 putative Mg++ binding site [ion binding]; other site 448385017514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385017515 nucleotide binding region [chemical binding]; other site 448385017516 ATP-binding site [chemical binding]; other site 448385017517 Helicase associated domain (HA2); Region: HA2; pfam04408 448385017518 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 448385017519 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 448385017520 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 448385017521 active site 448385017522 Zn binding site [ion binding]; other site 448385017523 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 448385017524 nucleic acid binding site [nucleotide binding]; other site 448385017525 TIGR03118 family protein; Region: PEPCTERM_chp_1 448385017526 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 448385017527 active site 448385017528 metal binding site [ion binding]; metal-binding site 448385017529 homotetramer interface [polypeptide binding]; other site 448385017530 hypothetical protein; Provisional; Region: PRK06184 448385017531 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385017532 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385017533 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385017534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385017535 putative DNA binding site [nucleotide binding]; other site 448385017536 putative Zn2+ binding site [ion binding]; other site 448385017537 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017539 active site 448385017540 ATP binding site [chemical binding]; other site 448385017541 substrate binding site [chemical binding]; other site 448385017542 activation loop (A-loop); other site 448385017543 Predicted ATPase [General function prediction only]; Region: COG3899 448385017544 AAA ATPase domain; Region: AAA_16; pfam13191 448385017545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017546 binding surface 448385017547 TPR motif; other site 448385017548 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 448385017549 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 448385017550 dimer interface [polypeptide binding]; other site 448385017551 active site 448385017552 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385017553 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385017554 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385017555 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 448385017556 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 448385017557 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 448385017558 homodimer interface [polypeptide binding]; other site 448385017559 active site 448385017560 FMN binding site [chemical binding]; other site 448385017561 substrate binding site [chemical binding]; other site 448385017562 4Fe-4S binding domain; Region: Fer4; pfam00037 448385017563 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 448385017564 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 448385017565 phenylhydantoinase; Validated; Region: PRK08323 448385017566 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 448385017567 tetramer interface [polypeptide binding]; other site 448385017568 active site 448385017569 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 448385017570 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 448385017571 active site 448385017572 catalytic triad [active] 448385017573 dimer interface [polypeptide binding]; other site 448385017574 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 448385017575 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 448385017576 tetrameric interface [polypeptide binding]; other site 448385017577 NAD binding site [chemical binding]; other site 448385017578 catalytic residues [active] 448385017579 hypothetical protein; Provisional; Region: PRK07877 448385017580 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 448385017581 ATP binding site [chemical binding]; other site 448385017582 substrate interface [chemical binding]; other site 448385017583 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 448385017584 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 448385017585 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385017586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385017587 phosphorylation site [posttranslational modification] 448385017588 intermolecular recognition site; other site 448385017589 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385017590 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385017591 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385017592 dinuclear metal binding motif [ion binding]; other site 448385017593 photolyase PhrII; Region: phr2; TIGR00591 448385017594 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 448385017595 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 448385017596 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017597 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385017598 active site 448385017599 ATP binding site [chemical binding]; other site 448385017600 substrate binding site [chemical binding]; other site 448385017601 activation loop (A-loop); other site 448385017602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017603 binding surface 448385017604 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385017605 TPR motif; other site 448385017606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 448385017607 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 448385017608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385017609 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385017610 putative active site [active] 448385017611 hypothetical protein; Provisional; Region: PRK06062 448385017612 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385017613 inhibitor-cofactor binding pocket; inhibition site 448385017614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385017615 catalytic residue [active] 448385017616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 448385017617 putative dimer interface [polypeptide binding]; other site 448385017618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385017619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385017620 dimerization interface [polypeptide binding]; other site 448385017621 putative DNA binding site [nucleotide binding]; other site 448385017622 putative Zn2+ binding site [ion binding]; other site 448385017623 Transcriptional regulators [Transcription]; Region: MarR; COG1846 448385017624 MarR family; Region: MarR_2; pfam12802 448385017625 Cytochrome P450; Region: p450; cl12078 448385017626 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385017627 Cytochrome P450; Region: p450; pfam00067 448385017628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385017629 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017630 active site 448385017631 ATP binding site [chemical binding]; other site 448385017632 substrate binding site [chemical binding]; other site 448385017633 activation loop (A-loop); other site 448385017634 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 448385017635 heme-binding site [chemical binding]; other site 448385017636 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385017637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385017638 S-adenosylmethionine binding site [chemical binding]; other site 448385017639 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385017640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385017641 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385017642 ligand binding site [chemical binding]; other site 448385017643 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 448385017644 isocitrate dehydrogenase; Validated; Region: PRK06451 448385017645 Smr domain; Region: Smr; pfam01713 448385017646 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385017647 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385017648 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 448385017649 dimer interface [polypeptide binding]; other site 448385017650 ADP-ribose binding site [chemical binding]; other site 448385017651 active site 448385017652 nudix motif; other site 448385017653 metal binding site [ion binding]; metal-binding site 448385017654 Peptidase M15; Region: Peptidase_M15_3; cl01194 448385017655 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 448385017656 putative active site [active] 448385017657 dimerization interface [polypeptide binding]; other site 448385017658 putative tRNAtyr binding site [nucleotide binding]; other site 448385017659 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 448385017660 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385017661 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 448385017662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385017663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385017664 DNA binding site [nucleotide binding] 448385017665 protease TldD; Provisional; Region: tldD; PRK10735 448385017666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017667 TPR motif; other site 448385017668 binding surface 448385017669 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 448385017670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017671 TPR motif; other site 448385017672 binding surface 448385017673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017674 TPR motif; other site 448385017675 binding surface 448385017676 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017677 TPR motif; other site 448385017678 binding surface 448385017679 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 448385017680 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 448385017681 active site 448385017682 tellurium resistance terB-like protein; Region: terB_like; cd07177 448385017683 metal binding site [ion binding]; metal-binding site 448385017684 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 448385017685 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 448385017686 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385017687 protein binding site [polypeptide binding]; other site 448385017688 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 448385017689 Catalytic dyad [active] 448385017690 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 448385017691 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 448385017692 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 448385017693 nucleotide binding site [chemical binding]; other site 448385017694 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385017695 SBD interface [polypeptide binding]; other site 448385017696 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385017697 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 448385017698 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385017699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385017700 Amidohydrolase; Region: Amidohydro_4; pfam13147 448385017701 active site 448385017702 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385017703 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 448385017704 catalytic domain interface [polypeptide binding]; other site 448385017705 homodimer interface [polypeptide binding]; other site 448385017706 putative active site [active] 448385017707 Protein of unknown function, DUF608; Region: DUF608; pfam04685 448385017708 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385017709 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385017710 active site 448385017711 catalytic tetrad [active] 448385017712 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385017713 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385017714 ligand binding site [chemical binding]; other site 448385017715 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 448385017716 nucleotide binding site [chemical binding]; other site 448385017717 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385017718 SBD interface [polypeptide binding]; other site 448385017719 DNA-K related protein; Region: DUF3731; pfam12531 448385017720 eight-cysteine-cluster domain; Region: heavy_Cys; TIGR04289 448385017721 eight-cysteine-cluster domain; Region: heavy_Cys; TIGR04289 448385017722 eight-cysteine-cluster domain; Region: heavy_Cys; TIGR04289 448385017723 Beta propeller domain; Region: Beta_propel; pfam09826 448385017724 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385017725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385017726 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 448385017727 putative GSH binding site [chemical binding]; other site 448385017728 catalytic residues [active] 448385017729 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 448385017730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 448385017731 active site residue [active] 448385017732 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385017733 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385017734 phosphopeptide binding site; other site 448385017735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017736 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385017737 Walker A motif; other site 448385017738 ATP binding site [chemical binding]; other site 448385017739 Walker B motif; other site 448385017740 arginine finger; other site 448385017741 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385017742 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 448385017743 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 448385017744 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 448385017745 HPP family; Region: HPP; pfam04982 448385017746 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385017747 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385017748 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 448385017749 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 448385017750 putative active site [active] 448385017751 putative metal binding site [ion binding]; other site 448385017752 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 448385017753 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385017754 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 448385017755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385017756 RNA binding surface [nucleotide binding]; other site 448385017757 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385017758 active site 448385017759 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385017760 Protein phosphatase 2C; Region: PP2C; pfam00481 448385017761 active site 448385017762 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385017763 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385017764 ligand binding site [chemical binding]; other site 448385017765 flexible hinge region; other site 448385017766 hypothetical protein; Reviewed; Region: PRK00024 448385017767 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 448385017768 MPN+ (JAMM) motif; other site 448385017769 Zinc-binding site [ion binding]; other site 448385017770 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 448385017771 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 448385017772 putative MPT binding site; other site 448385017773 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 448385017774 HEAT repeats; Region: HEAT_2; pfam13646 448385017775 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 448385017776 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385017777 FeS/SAM binding site; other site 448385017778 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017779 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017780 active site 448385017781 ATP binding site [chemical binding]; other site 448385017782 substrate binding site [chemical binding]; other site 448385017783 activation loop (A-loop); other site 448385017784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385017785 Coenzyme A binding pocket [chemical binding]; other site 448385017786 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385017787 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 448385017788 putative acyl-acceptor binding pocket; other site 448385017789 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385017790 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 448385017791 putative NAD(P) binding site [chemical binding]; other site 448385017792 active site 448385017793 putative substrate binding site [chemical binding]; other site 448385017794 Nudix hydrolase homolog; Region: PLN02791 448385017795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385017796 binding surface 448385017797 TPR motif; other site 448385017798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385017799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385017800 active site 448385017801 ATP binding site [chemical binding]; other site 448385017802 substrate binding site [chemical binding]; other site 448385017803 activation loop (A-loop); other site 448385017804 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385017805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017806 Walker A motif; other site 448385017807 ATP binding site [chemical binding]; other site 448385017808 Walker B motif; other site 448385017809 arginine finger; other site 448385017810 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 448385017811 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385017812 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385017813 metal ion-dependent adhesion site (MIDAS); other site 448385017814 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385017815 metal ion-dependent adhesion site (MIDAS); other site 448385017816 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385017817 metal ion-dependent adhesion site (MIDAS); other site 448385017818 Oxygen tolerance; Region: BatD; pfam13584 448385017819 Outer membrane lipoprotein; Region: YfiO; pfam13525 448385017820 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 448385017821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385017822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385017823 non-specific DNA binding site [nucleotide binding]; other site 448385017824 salt bridge; other site 448385017825 sequence-specific DNA binding site [nucleotide binding]; other site 448385017826 Cupin domain; Region: Cupin_2; pfam07883 448385017827 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 448385017828 PLD-like domain; Region: PLDc_2; pfam13091 448385017829 putative active site [active] 448385017830 catalytic site [active] 448385017831 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 448385017832 PLD-like domain; Region: PLDc_2; pfam13091 448385017833 putative active site [active] 448385017834 catalytic site [active] 448385017835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385017836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385017837 Walker A motif; other site 448385017838 ATP binding site [chemical binding]; other site 448385017839 Walker B motif; other site 448385017840 arginine finger; other site 448385017841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 448385017842 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385017843 putative active site [active] 448385017844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385017845 ATP binding site [chemical binding]; other site 448385017846 Mg2+ binding site [ion binding]; other site 448385017847 G-X-G motif; other site 448385017848 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 448385017849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 448385017850 B12 binding site [chemical binding]; other site 448385017851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385017852 FeS/SAM binding site; other site 448385017853 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 448385017854 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 448385017855 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 448385017856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 448385017857 Mg2+ binding site [ion binding]; other site 448385017858 G-X-G motif; other site 448385017859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385017860 ATP binding site [chemical binding]; other site 448385017861 Mg2+ binding site [ion binding]; other site 448385017862 G-X-G motif; other site 448385017863 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385017864 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 448385017865 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 448385017866 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385017867 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385017868 putative C-terminal domain interface [polypeptide binding]; other site 448385017869 putative GSH binding site (G-site) [chemical binding]; other site 448385017870 putative dimer interface [polypeptide binding]; other site 448385017871 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385017872 N-terminal domain interface [polypeptide binding]; other site 448385017873 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 448385017874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385017875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385017876 Walker A/P-loop; other site 448385017877 ATP binding site [chemical binding]; other site 448385017878 Q-loop/lid; other site 448385017879 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385017880 ABC transporter signature motif; other site 448385017881 Walker B; other site 448385017882 D-loop; other site 448385017883 ABC transporter; Region: ABC_tran_2; pfam12848 448385017884 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385017885 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 448385017886 catalytic residues [active] 448385017887 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 448385017888 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385017889 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385017890 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385017891 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385017892 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385017893 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385017894 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 448385017895 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934 448385017896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385017897 active site 448385017898 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 448385017899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385017900 active site 448385017901 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 448385017902 S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672 448385017903 putative RNA binding site [nucleotide binding]; other site 448385017904 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385017905 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 448385017906 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 448385017907 GAF domain; Region: GAF; pfam01590 448385017908 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385017909 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385017910 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385017911 Predicted aminopeptidase (DUF2265); Region: DUF2265; cl17720 448385017912 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 448385017913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385017914 S-adenosylmethionine binding site [chemical binding]; other site 448385017915 UreD urease accessory protein; Region: UreD; pfam01774 448385017916 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 448385017917 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 448385017918 alpha-gamma subunit interface [polypeptide binding]; other site 448385017919 beta-gamma subunit interface [polypeptide binding]; other site 448385017920 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 448385017921 gamma-beta subunit interface [polypeptide binding]; other site 448385017922 alpha-beta subunit interface [polypeptide binding]; other site 448385017923 urease subunit alpha; Reviewed; Region: ureC; PRK13207 448385017924 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 448385017925 subunit interactions [polypeptide binding]; other site 448385017926 active site 448385017927 flap region; other site 448385017928 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 448385017929 UreF; Region: UreF; pfam01730 448385017930 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385017931 Response regulator receiver domain; Region: Response_reg; pfam00072 448385017932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385017933 active site 448385017934 phosphorylation site [posttranslational modification] 448385017935 intermolecular recognition site; other site 448385017936 dimerization interface [polypeptide binding]; other site 448385017937 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 448385017938 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 448385017939 putative Iron-sulfur protein interface [polypeptide binding]; other site 448385017940 proximal heme binding site [chemical binding]; other site 448385017941 distal heme binding site [chemical binding]; other site 448385017942 putative dimer interface [polypeptide binding]; other site 448385017943 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 448385017944 L-aspartate oxidase; Provisional; Region: PRK06175 448385017945 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 448385017946 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 448385017947 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 448385017948 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 448385017949 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 448385017950 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 448385017951 Moco binding site; other site 448385017952 metal coordination site [ion binding]; other site 448385017953 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 448385017954 Protein of unknown function (DUF420); Region: DUF420; pfam04238 448385017955 glutathione reductase; Validated; Region: PRK06116 448385017956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385017957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385017958 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 448385017959 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 448385017960 putative trimer interface [polypeptide binding]; other site 448385017961 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 448385017962 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 448385017963 trimer interface [polypeptide binding]; other site 448385017964 active site 448385017965 substrate binding site [chemical binding]; other site 448385017966 putative CoA binding site [chemical binding]; other site 448385017967 CoA binding site [chemical binding]; other site 448385017968 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385017969 hypothetical protein; Validated; Region: PRK07080 448385017970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385017971 Coenzyme A binding pocket [chemical binding]; other site 448385017972 Pirin-related protein [General function prediction only]; Region: COG1741 448385017973 Pirin; Region: Pirin; pfam02678 448385017974 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 448385017975 active site 448385017976 catalytic triad [active] 448385017977 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385017978 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 448385017979 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385017980 putative active site [active] 448385017981 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 448385017982 Gram-negative bacterial tonB protein; Region: TonB; cl10048 448385017983 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 448385017984 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 448385017985 putative ADP-binding pocket [chemical binding]; other site 448385017986 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 448385017987 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 448385017988 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 448385017989 E3 interaction surface; other site 448385017990 lipoyl attachment site [posttranslational modification]; other site 448385017991 e3 binding domain; Region: E3_binding; pfam02817 448385017992 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 448385017993 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 448385017994 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 448385017995 dimer interface [polypeptide binding]; other site 448385017996 active site 448385017997 glycine-pyridoxal phosphate binding site [chemical binding]; other site 448385017998 folate binding site [chemical binding]; other site 448385017999 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 448385018000 IHF dimer interface [polypeptide binding]; other site 448385018001 IHF - DNA interface [nucleotide binding]; other site 448385018002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018003 TPR motif; other site 448385018004 binding surface 448385018005 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 448385018006 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385018007 substrate binding site [chemical binding]; other site 448385018008 oxyanion hole (OAH) forming residues; other site 448385018009 trimer interface [polypeptide binding]; other site 448385018010 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 448385018011 A new structural DNA glycosylase; Region: AlkD_like; cd06561 448385018012 active site 448385018013 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 448385018014 four helix bundle protein; Region: TIGR02436 448385018015 Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; Region: TNFR; cl12111 448385018016 protein binding site [polypeptide binding]; other site 448385018017 parallel homodimerization interface [polypeptide binding]; other site 448385018018 antiparallel homodimerization interface [polypeptide binding]; other site 448385018019 50's loop TNF binding site; other site 448385018020 90's loop TNF binding site; other site 448385018021 Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and...; Region: TNFR; cl12111 448385018022 parallel homodimerization interface [polypeptide binding]; other site 448385018023 protein binding site [polypeptide binding]; other site 448385018024 50's loop TNF binding site; other site 448385018025 Beta-propeller repeat; Region: SBBP; pfam06739 448385018026 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385018027 dinuclear metal binding motif [ion binding]; other site 448385018028 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 448385018029 Caspase domain; Region: Peptidase_C14; pfam00656 448385018030 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385018031 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385018032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385018033 DNA binding residues [nucleotide binding] 448385018034 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385018035 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 448385018036 Penicillinase repressor; Region: Pencillinase_R; pfam03965 448385018037 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 448385018038 Pirin-related protein [General function prediction only]; Region: COG1741 448385018039 Pirin; Region: Pirin; pfam02678 448385018040 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 448385018041 Winged helix-turn helix; Region: HTH_29; pfam13551 448385018042 Homeodomain-like domain; Region: HTH_32; pfam13565 448385018043 Integrase core domain; Region: rve; pfam00665 448385018044 DDE domain; Region: DDE_Tnp_IS240; pfam13610 448385018045 Integrase core domain; Region: rve_3; pfam13683 448385018046 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 448385018047 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385018048 putative active site [active] 448385018049 putative NTP binding site [chemical binding]; other site 448385018050 putative nucleic acid binding site [nucleotide binding]; other site 448385018051 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 448385018052 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 448385018053 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018054 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385018055 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385018056 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385018057 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018058 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385018059 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385018060 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385018061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018062 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385018063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018064 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385018065 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385018066 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385018067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018068 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 448385018069 Spondin_N; Region: Spond_N; pfam06468 448385018070 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 448385018071 Cytochrome P450; Region: p450; cl12078 448385018072 Cupin-like domain; Region: Cupin_8; pfam13621 448385018073 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385018074 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385018075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385018076 DNA binding residues [nucleotide binding] 448385018077 RibD C-terminal domain; Region: RibD_C; cl17279 448385018078 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385018079 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 448385018080 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 448385018081 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 448385018082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385018083 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385018084 FHA domain; Region: FHA; pfam00498 448385018085 phosphopeptide binding site; other site 448385018086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018087 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385018088 Walker A motif; other site 448385018089 ATP binding site [chemical binding]; other site 448385018090 Walker B motif; other site 448385018091 arginine finger; other site 448385018092 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385018093 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 448385018094 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 448385018095 Cupin; Region: Cupin_6; pfam12852 448385018096 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385018097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385018098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385018099 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 448385018100 PQQ-like domain; Region: PQQ_2; pfam13360 448385018101 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 448385018102 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 448385018103 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 448385018104 catalytic residues [active] 448385018105 catalytic nucleophile [active] 448385018106 Recombinase; Region: Recombinase; pfam07508 448385018107 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 448385018108 Recombinase; Region: Recombinase; pfam07508 448385018109 Helix-turn-helix domain; Region: HTH_28; pfam13518 448385018110 Winged helix-turn helix; Region: HTH_29; pfam13551 448385018111 Homeodomain-like domain; Region: HTH_32; pfam13565 448385018112 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 448385018113 Integrase core domain; Region: rve; pfam00665 448385018114 Integrase core domain; Region: rve_3; pfam13683 448385018115 Bacterial Ig-like domain; Region: Big_5; pfam13205 448385018116 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018117 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018118 active site 448385018119 ATP binding site [chemical binding]; other site 448385018120 substrate binding site [chemical binding]; other site 448385018121 activation loop (A-loop); other site 448385018122 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385018123 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385018124 phosphopeptide binding site; other site 448385018125 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385018126 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018127 Walker A motif; other site 448385018128 ATP binding site [chemical binding]; other site 448385018129 Walker B motif; other site 448385018130 arginine finger; other site 448385018131 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385018132 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385018133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385018134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385018135 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385018136 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 448385018137 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385018138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018139 active site 448385018140 ATP binding site [chemical binding]; other site 448385018141 substrate binding site [chemical binding]; other site 448385018142 activation loop (A-loop); other site 448385018143 AAA ATPase domain; Region: AAA_16; pfam13191 448385018144 Predicted ATPase [General function prediction only]; Region: COG3899 448385018145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385018146 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 448385018147 active site 448385018148 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385018149 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385018150 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385018151 dinuclear metal binding motif [ion binding]; other site 448385018152 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018153 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018154 active site 448385018155 ATP binding site [chemical binding]; other site 448385018156 substrate binding site [chemical binding]; other site 448385018157 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385018158 substrate binding site [chemical binding]; other site 448385018159 activation loop (A-loop); other site 448385018160 activation loop (A-loop); other site 448385018161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018162 TPR repeat; Region: TPR_11; pfam13414 448385018163 TPR motif; other site 448385018164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385018165 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 448385018166 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 448385018167 putative active site [active] 448385018168 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 448385018169 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385018170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385018171 catalytic residue [active] 448385018172 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 448385018173 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 448385018174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385018175 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 448385018176 FeS/SAM binding site; other site 448385018177 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 448385018178 Bacterial sugar transferase; Region: Bac_transf; pfam02397 448385018179 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 448385018180 classical (c) SDRs; Region: SDR_c; cd05233 448385018181 NAD(P) binding site [chemical binding]; other site 448385018182 active site 448385018183 Radical SAM superfamily; Region: Radical_SAM; pfam04055 448385018184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385018185 FeS/SAM binding site; other site 448385018186 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 448385018187 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385018188 NAD binding site [chemical binding]; other site 448385018189 putative substrate binding site 2 [chemical binding]; other site 448385018190 putative substrate binding site 1 [chemical binding]; other site 448385018191 active site 448385018192 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 448385018193 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 448385018194 active site 448385018195 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385018196 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 448385018197 Kelch domain; Region: Kelch; smart00612 448385018198 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018199 Kelch domain; Region: Kelch; smart00612 448385018200 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385018201 Kelch domain; Region: Kelch; smart00612 448385018202 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 448385018203 hypothetical protein; Provisional; Region: PRK06126 448385018204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385018205 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385018206 Cytochrome c; Region: Cytochrom_C; cl11414 448385018207 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 448385018208 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385018209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385018210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385018211 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 448385018212 CHAT domain; Region: CHAT; pfam12770 448385018213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018214 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018215 binding surface 448385018216 TPR motif; other site 448385018217 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018219 binding surface 448385018220 TPR motif; other site 448385018221 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018223 CHAT domain; Region: CHAT; cl17868 448385018224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018225 TPR motif; other site 448385018226 binding surface 448385018227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018229 binding surface 448385018230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018231 TPR motif; other site 448385018232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018233 CHAT domain; Region: CHAT; pfam12770 448385018234 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018235 TPR repeat; Region: TPR_11; pfam13414 448385018236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018237 binding surface 448385018238 TPR motif; other site 448385018239 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018240 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385018241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385018242 DNA binding residues [nucleotide binding] 448385018243 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385018244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018245 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385018246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385018247 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385018248 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385018249 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385018250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385018251 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385018252 PEGA domain; Region: PEGA; pfam08308 448385018253 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 448385018254 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 448385018255 active site 448385018256 catalytic residues [active] 448385018257 DNA binding site [nucleotide binding] 448385018258 Int/Topo IB signature motif; other site 448385018259 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 448385018260 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385018261 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385018262 FtsX-like permease family; Region: FtsX; pfam02687 448385018263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385018264 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 448385018265 FtsX-like permease family; Region: FtsX; pfam02687 448385018266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385018267 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385018268 Walker A/P-loop; other site 448385018269 ATP binding site [chemical binding]; other site 448385018270 Q-loop/lid; other site 448385018271 ABC transporter signature motif; other site 448385018272 Walker B; other site 448385018273 D-loop; other site 448385018274 H-loop/switch region; other site 448385018275 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385018276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385018277 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385018278 Salmonella virulence plasmid 28.1kDa A protein; Region: VRP1; pfam03538 448385018279 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 448385018280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385018281 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385018282 Family description; Region: VCBS; pfam13517 448385018283 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 448385018284 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 448385018285 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385018286 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385018287 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 448385018288 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 448385018289 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 448385018290 MOSC domain; Region: MOSC; pfam03473 448385018291 Gametolysin peptidase M11; Region: Peptidase_M11; pfam05548 448385018292 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 448385018293 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385018294 putative sugar binding sites [chemical binding]; other site 448385018295 Q-X-W motif; other site 448385018296 VPS10 domain; Region: VPS10; smart00602 448385018297 Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112 448385018298 Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113 448385018299 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385018300 active site 448385018301 Uncharacterized conserved protein [Function unknown]; Region: COG1656 448385018302 Protein of unknown function DUF82; Region: DUF82; pfam01927 448385018303 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 448385018304 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385018305 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018306 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018307 active site 448385018308 ATP binding site [chemical binding]; other site 448385018309 substrate binding site [chemical binding]; other site 448385018310 activation loop (A-loop); other site 448385018311 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 448385018312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385018313 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385018314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385018315 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385018316 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385018317 putative C-terminal domain interface [polypeptide binding]; other site 448385018318 putative GSH binding site (G-site) [chemical binding]; other site 448385018319 putative dimer interface [polypeptide binding]; other site 448385018320 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 448385018321 dimer interface [polypeptide binding]; other site 448385018322 N-terminal domain interface [polypeptide binding]; other site 448385018323 putative substrate binding pocket (H-site) [chemical binding]; other site 448385018324 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 448385018325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018326 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018327 active site 448385018328 ATP binding site [chemical binding]; other site 448385018329 substrate binding site [chemical binding]; other site 448385018330 activation loop (A-loop); other site 448385018331 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 448385018332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018333 binding surface 448385018334 TPR motif; other site 448385018335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018336 CHAT domain; Region: CHAT; pfam12770 448385018337 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385018338 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385018339 phosphopeptide binding site; other site 448385018340 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385018341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018342 Walker A motif; other site 448385018343 ATP binding site [chemical binding]; other site 448385018344 Walker B motif; other site 448385018345 arginine finger; other site 448385018346 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 448385018347 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 448385018348 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 448385018349 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 448385018350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385018351 Walker A/P-loop; other site 448385018352 ATP binding site [chemical binding]; other site 448385018353 Q-loop/lid; other site 448385018354 ABC transporter signature motif; other site 448385018355 Walker B; other site 448385018356 D-loop; other site 448385018357 H-loop/switch region; other site 448385018358 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 448385018359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385018360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385018361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385018362 dimerization interface [polypeptide binding]; other site 448385018363 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385018364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385018365 S-adenosylmethionine binding site [chemical binding]; other site 448385018366 Uncharacterized conserved protein [Function unknown]; Region: COG1479 448385018367 Protein of unknown function DUF262; Region: DUF262; pfam03235 448385018368 Uncharacterized conserved protein [Function unknown]; Region: COG3472 448385018369 Predicted ATPase [General function prediction only]; Region: COG4637 448385018370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385018371 Walker A/P-loop; other site 448385018372 ATP binding site [chemical binding]; other site 448385018373 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 448385018374 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385018375 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385018376 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385018377 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385018378 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385018379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385018380 TPR motif; other site 448385018381 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018382 bHLH-MYC and R2R3-MYB transcription factors N-terminal; Region: bHLH-MYC_N; pfam14215 448385018383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385018384 PAS domain; Region: PAS_9; pfam13426 448385018385 putative active site [active] 448385018386 heme pocket [chemical binding]; other site 448385018387 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385018388 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385018389 putative catalytic site [active] 448385018390 putative metal binding site [ion binding]; other site 448385018391 putative phosphate binding site [ion binding]; other site 448385018392 Lamin Tail Domain; Region: LTD; pfam00932 448385018393 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 448385018394 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 448385018395 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 448385018396 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 448385018397 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385018398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385018399 NAD(P) binding site [chemical binding]; other site 448385018400 active site 448385018401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385018402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385018403 NAD(P) binding site [chemical binding]; other site 448385018404 active site 448385018405 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 448385018406 B12 binding domain; Region: B12-binding; pfam02310 448385018407 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385018408 FeS/SAM binding site; other site 448385018409 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385018410 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385018411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385018412 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 448385018413 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385018414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385018415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385018416 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385018417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385018418 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385018419 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385018420 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 448385018421 NAD binding site [chemical binding]; other site 448385018422 putative substrate binding site 2 [chemical binding]; other site 448385018423 putative substrate binding site 1 [chemical binding]; other site 448385018424 active site 448385018425 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385018426 putative active site [active] 448385018427 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385018428 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385018429 WHG domain; Region: WHG; pfam13305 448385018430 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 448385018431 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385018432 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385018433 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385018434 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 448385018435 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385018436 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018437 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385018438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018439 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018440 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018441 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018442 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018443 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385018444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018446 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385018447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018449 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385018450 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018451 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385018452 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385018453 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385018454 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 448385018455 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 448385018456 putative ADP-binding pocket [chemical binding]; other site 448385018457 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 448385018458 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 448385018459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385018460 S-adenosylmethionine binding site [chemical binding]; other site 448385018461 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385018462 active site 448385018463 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385018464 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385018465 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385018466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 448385018467 PAS domain; Region: PAS_9; pfam13426 448385018468 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385018469 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 448385018470 ADP-ribose binding site [chemical binding]; other site 448385018471 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 448385018472 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 448385018473 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385018474 cleavage site 448385018475 active site 448385018476 Beta/Gamma crystallin; Region: Crystall; cl02528 448385018477 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 448385018478 S1 domain; Region: S1_2; pfam13509 448385018479 S1 domain; Region: S1_2; pfam13509 448385018480 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 448385018481 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 448385018482 dimerization interface [polypeptide binding]; other site 448385018483 DPS ferroxidase diiron center [ion binding]; other site 448385018484 ion pore; other site 448385018485 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385018486 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 448385018487 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 448385018488 active site 448385018489 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 448385018490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385018491 ATP binding site [chemical binding]; other site 448385018492 putative Mg++ binding site [ion binding]; other site 448385018493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385018494 nucleotide binding region [chemical binding]; other site 448385018495 ATP-binding site [chemical binding]; other site 448385018496 Protein of unknown function (DUF790); Region: DUF790; pfam05626 448385018497 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 448385018498 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 448385018499 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 448385018500 active site 448385018501 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 448385018502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385018503 active site 448385018504 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 448385018505 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 448385018506 oligomer interface [polypeptide binding]; other site 448385018507 metal binding site [ion binding]; metal-binding site 448385018508 metal binding site [ion binding]; metal-binding site 448385018509 Cl binding site [ion binding]; other site 448385018510 aspartate ring; other site 448385018511 basic sphincter; other site 448385018512 putative hydrophobic gate; other site 448385018513 periplasmic entrance; other site 448385018514 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385018515 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 448385018516 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 448385018517 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 448385018518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385018519 Walker A/P-loop; other site 448385018520 ATP binding site [chemical binding]; other site 448385018521 Q-loop/lid; other site 448385018522 ABC transporter signature motif; other site 448385018523 Walker B; other site 448385018524 D-loop; other site 448385018525 H-loop/switch region; other site 448385018526 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 448385018527 Condensation domain; Region: Condensation; pfam00668 448385018528 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385018529 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385018530 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385018531 acyl-activating enzyme (AAE) consensus motif; other site 448385018532 AMP binding site [chemical binding]; other site 448385018533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385018534 Condensation domain; Region: Condensation; pfam00668 448385018535 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385018536 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385018537 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385018538 acyl-activating enzyme (AAE) consensus motif; other site 448385018539 AMP binding site [chemical binding]; other site 448385018540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385018541 S-adenosylmethionine binding site [chemical binding]; other site 448385018542 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385018543 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385018544 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385018545 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385018546 active site 448385018547 Acyl transferase domain; Region: Acyl_transf_1; cl08282 448385018548 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 448385018549 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385018550 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385018551 ATP binding site [chemical binding]; other site 448385018552 putative Mg++ binding site [ion binding]; other site 448385018553 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 448385018554 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018555 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018556 active site 448385018557 ATP binding site [chemical binding]; other site 448385018558 substrate binding site [chemical binding]; other site 448385018559 activation loop (A-loop); other site 448385018560 Predicted ATPase [General function prediction only]; Region: COG3899 448385018561 AAA ATPase domain; Region: AAA_16; pfam13191 448385018562 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385018563 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385018564 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385018565 Response regulator receiver domain; Region: Response_reg; pfam00072 448385018566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385018567 active site 448385018568 phosphorylation site [posttranslational modification] 448385018569 intermolecular recognition site; other site 448385018570 dimerization interface [polypeptide binding]; other site 448385018571 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 448385018572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385018573 putative active site [active] 448385018574 heme pocket [chemical binding]; other site 448385018575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385018576 dimer interface [polypeptide binding]; other site 448385018577 phosphorylation site [posttranslational modification] 448385018578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385018579 ATP binding site [chemical binding]; other site 448385018580 Mg2+ binding site [ion binding]; other site 448385018581 G-X-G motif; other site 448385018582 Response regulator receiver domain; Region: Response_reg; pfam00072 448385018583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385018584 active site 448385018585 phosphorylation site [posttranslational modification] 448385018586 intermolecular recognition site; other site 448385018587 dimerization interface [polypeptide binding]; other site 448385018588 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018590 active site 448385018591 ATP binding site [chemical binding]; other site 448385018592 substrate binding site [chemical binding]; other site 448385018593 activation loop (A-loop); other site 448385018594 Predicted ATPase [General function prediction only]; Region: COG3899 448385018595 AAA ATPase domain; Region: AAA_16; pfam13191 448385018596 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385018597 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385018598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385018599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385018600 dimer interface [polypeptide binding]; other site 448385018601 phosphorylation site [posttranslational modification] 448385018602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385018603 ATP binding site [chemical binding]; other site 448385018604 Mg2+ binding site [ion binding]; other site 448385018605 G-X-G motif; other site 448385018606 Response regulator receiver domain; Region: Response_reg; pfam00072 448385018607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385018608 active site 448385018609 phosphorylation site [posttranslational modification] 448385018610 intermolecular recognition site; other site 448385018611 dimerization interface [polypeptide binding]; other site 448385018612 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385018613 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 448385018614 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385018615 putative catalytic site [active] 448385018616 putative phosphate binding site [ion binding]; other site 448385018617 putative metal binding site [ion binding]; other site 448385018618 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 448385018619 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 448385018620 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 448385018621 Uncharacterized conserved protein [Function unknown]; Region: COG2128 448385018622 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 448385018623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385018624 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385018625 SnoaL-like domain; Region: SnoaL_2; pfam12680 448385018626 Cupin domain; Region: Cupin_2; cl17218 448385018627 DJ-1 family protein; Region: not_thiJ; TIGR01383 448385018628 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 448385018629 conserved cys residue [active] 448385018630 Pectate lyase; Region: Pec_lyase_C; cl01593 448385018631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385018632 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018633 active site 448385018634 ATP binding site [chemical binding]; other site 448385018635 substrate binding site [chemical binding]; other site 448385018636 activation loop (A-loop); other site 448385018637 AAA ATPase domain; Region: AAA_16; pfam13191 448385018638 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385018639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018640 Walker A motif; other site 448385018641 ATP binding site [chemical binding]; other site 448385018642 Walker B motif; other site 448385018643 arginine finger; other site 448385018644 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385018645 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 448385018646 four helix bundle protein; Region: TIGR02436 448385018647 Protein kinase domain; Region: Pkinase; pfam00069 448385018648 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018649 active site 448385018650 ATP binding site [chemical binding]; other site 448385018651 substrate binding site [chemical binding]; other site 448385018652 activation loop (A-loop); other site 448385018653 AAA ATPase domain; Region: AAA_16; pfam13191 448385018654 Predicted ATPase [General function prediction only]; Region: COG3899 448385018655 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385018656 TPR motif; other site 448385018657 binding surface 448385018658 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385018659 GAF domain; Region: GAF; pfam01590 448385018660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385018661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385018662 ATP binding site [chemical binding]; other site 448385018663 Mg2+ binding site [ion binding]; other site 448385018664 G-X-G motif; other site 448385018665 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 448385018666 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385018667 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 448385018668 active site 448385018669 catalytic residues [active] 448385018670 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 448385018671 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 448385018672 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 448385018673 active site 448385018674 catalytic site [active] 448385018675 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 448385018676 Kelch domain; Region: Kelch; smart00612 448385018677 Kelch motif; Region: Kelch_1; pfam01344 448385018678 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018679 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018680 Kelch domain; Region: Kelch; smart00612 448385018681 Kelch motif; Region: Kelch_1; pfam01344 448385018682 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018683 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018684 Kelch domain; Region: Kelch; smart00612 448385018685 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018686 Kelch domain; Region: Kelch; smart00612 448385018687 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018688 Kelch domain; Region: Kelch; smart00612 448385018689 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018690 Kelch motif; Region: Kelch_6; pfam13964 448385018691 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018692 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385018693 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018694 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385018695 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018696 Kelch domain; Region: Kelch; smart00612 448385018697 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018698 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385018699 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 448385018700 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 448385018701 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018702 Kelch motif; Region: Kelch_1; pfam01344 448385018703 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018704 Kelch domain; Region: Kelch; smart00612 448385018705 Kelch motif; Region: Kelch_1; pfam01344 448385018706 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018707 Kelch domain; Region: Kelch; smart00612 448385018708 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018709 Kelch domain; Region: Kelch; smart00612 448385018710 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018711 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 448385018712 Kelch motif; Region: Kelch_6; pfam13964 448385018713 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018714 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018715 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 448385018716 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018717 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 448385018718 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385018719 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 448385018720 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 448385018721 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 448385018722 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385018723 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 448385018724 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 448385018725 active site 448385018726 DNA binding site [nucleotide binding] 448385018727 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 448385018728 DNA binding site [nucleotide binding] 448385018729 AAA ATPase domain; Region: AAA_16; pfam13191 448385018730 Predicted ATPase [General function prediction only]; Region: COG3903 448385018731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018732 putative transposase OrfB; Reviewed; Region: PHA02517 448385018733 Integrase core domain; Region: rve; pfam00665 448385018734 Integrase core domain; Region: rve_3; pfam13683 448385018735 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385018736 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385018737 Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the...; Region: KAZAL_FS; cd00104 448385018738 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 448385018739 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 448385018740 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 448385018741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018742 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385018743 Walker A motif; other site 448385018744 ATP binding site [chemical binding]; other site 448385018745 Walker B motif; other site 448385018746 arginine finger; other site 448385018747 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385018748 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385018749 activation loop (A-loop); other site 448385018750 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 448385018751 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 448385018752 active site 448385018753 NTP binding site [chemical binding]; other site 448385018754 metal binding triad [ion binding]; metal-binding site 448385018755 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 448385018756 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 448385018757 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 448385018758 hinge; other site 448385018759 active site 448385018760 cytidylate kinase; Provisional; Region: cmk; PRK00023 448385018761 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 448385018762 active site 448385018763 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 448385018764 CMP-binding site; other site 448385018765 The sites determining sugar specificity; other site 448385018766 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 448385018767 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 448385018768 RNA binding site [nucleotide binding]; other site 448385018769 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 448385018770 RNA binding site [nucleotide binding]; other site 448385018771 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 448385018772 RNA binding site [nucleotide binding]; other site 448385018773 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385018774 RNA binding site [nucleotide binding]; other site 448385018775 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 448385018776 RNA binding site [nucleotide binding]; other site 448385018777 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 448385018778 RNA binding site [nucleotide binding]; other site 448385018779 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 448385018780 nucleotide binding site/active site [active] 448385018781 HIT family signature motif; other site 448385018782 catalytic residue [active] 448385018783 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 448385018784 Domain of unknown function DUF20; Region: UPF0118; pfam01594 448385018785 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 448385018786 conserved cys residue [active] 448385018787 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 448385018788 nucleotide binding site/active site [active] 448385018789 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 448385018790 active site clefts [active] 448385018791 zinc binding site [ion binding]; other site 448385018792 dimer interface [polypeptide binding]; other site 448385018793 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 448385018794 Sulfate transporter family; Region: Sulfate_transp; pfam00916 448385018795 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 448385018796 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385018797 FAD binding domain; Region: FAD_binding_4; pfam01565 448385018798 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 448385018799 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385018800 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385018801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385018802 catalytic residue [active] 448385018803 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018804 TPR repeat; Region: TPR_11; pfam13414 448385018805 binding surface 448385018806 TPR motif; other site 448385018807 PEGA domain; Region: PEGA; pfam08308 448385018808 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018809 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018810 active site 448385018811 ATP binding site [chemical binding]; other site 448385018812 substrate binding site [chemical binding]; other site 448385018813 activation loop (A-loop); other site 448385018814 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 448385018815 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 448385018816 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 448385018817 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 448385018818 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 448385018819 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 448385018820 RNA ligase; Region: RNA_ligase; pfam09414 448385018821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385018822 Zn2+ binding site [ion binding]; other site 448385018823 Mg2+ binding site [ion binding]; other site 448385018824 AAA domain; Region: AAA_33; pfam13671 448385018825 AAA domain; Region: AAA_17; pfam13207 448385018826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385018827 Walker A motif; other site 448385018828 ATP binding site [chemical binding]; other site 448385018829 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 448385018830 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385018831 substrate binding site [chemical binding]; other site 448385018832 oxyanion hole (OAH) forming residues; other site 448385018833 trimer interface [polypeptide binding]; other site 448385018834 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 448385018835 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385018836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385018837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385018838 active site 448385018839 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 448385018840 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 448385018841 putative dimer interface [polypeptide binding]; other site 448385018842 active site pocket [active] 448385018843 putative cataytic base [active] 448385018844 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 448385018845 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 448385018846 agmatinase; Region: agmatinase; TIGR01230 448385018847 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 448385018848 active site 448385018849 metal binding site [ion binding]; metal-binding site 448385018850 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 448385018851 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 448385018852 active site residue [active] 448385018853 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 448385018854 active site residue [active] 448385018855 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385018856 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385018857 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385018858 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385018859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018860 binding surface 448385018861 TPR motif; other site 448385018862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018863 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385018864 binding surface 448385018865 TPR motif; other site 448385018866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018867 TPR motif; other site 448385018868 binding surface 448385018869 TPR repeat; Region: TPR_11; pfam13414 448385018870 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 448385018871 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385018872 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385018873 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385018874 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385018875 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385018876 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385018877 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385018878 Domain of unknown function DUF87; Region: DUF87; pfam01935 448385018879 HerA helicase [Replication, recombination, and repair]; Region: COG0433 448385018880 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018881 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018882 active site 448385018883 ATP binding site [chemical binding]; other site 448385018884 substrate binding site [chemical binding]; other site 448385018885 activation loop (A-loop); other site 448385018886 Predicted membrane protein [Function unknown]; Region: COG4325 448385018887 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385018888 binding surface 448385018889 TPR motif; other site 448385018890 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 448385018891 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 448385018892 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 448385018893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385018894 DsbD alpha interface [polypeptide binding]; other site 448385018895 catalytic residues [active] 448385018896 transcription termination factor Rho; Provisional; Region: rho; PRK09376 448385018897 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 448385018898 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 448385018899 active site 448385018900 Riboflavin kinase; Region: Flavokinase; pfam01687 448385018901 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 448385018902 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 448385018903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385018904 active site 448385018905 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 448385018906 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 448385018907 5S rRNA interface [nucleotide binding]; other site 448385018908 CTC domain interface [polypeptide binding]; other site 448385018909 L16 interface [polypeptide binding]; other site 448385018910 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 448385018911 putative active site [active] 448385018912 catalytic residue [active] 448385018913 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 448385018914 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 448385018915 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 448385018916 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 448385018917 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 448385018918 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 448385018919 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 448385018920 substrate binding site [chemical binding]; other site 448385018921 ATP binding site [chemical binding]; other site 448385018922 replicative DNA helicase; Region: DnaB; TIGR00665 448385018923 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 448385018924 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 448385018925 Walker A motif; other site 448385018926 ATP binding site [chemical binding]; other site 448385018927 Walker B motif; other site 448385018928 DNA binding loops [nucleotide binding] 448385018929 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 448385018930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385018931 Mg2+ binding site [ion binding]; other site 448385018932 G-X-G motif; other site 448385018933 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 448385018934 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 448385018935 Peptidase M15; Region: Peptidase_M15_3; cl01194 448385018936 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 448385018937 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 448385018938 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385018939 active site 448385018940 FIST C domain; Region: FIST_C; pfam10442 448385018941 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385018942 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385018943 active site 448385018944 ATP binding site [chemical binding]; other site 448385018945 substrate binding site [chemical binding]; other site 448385018946 activation loop (A-loop); other site 448385018947 Predicted integral membrane protein [Function unknown]; Region: COG5616 448385018948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385018949 TPR motif; other site 448385018950 binding surface 448385018951 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 448385018952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385018953 Walker A/P-loop; other site 448385018954 ATP binding site [chemical binding]; other site 448385018955 Q-loop/lid; other site 448385018956 ABC transporter signature motif; other site 448385018957 Walker B; other site 448385018958 D-loop; other site 448385018959 H-loop/switch region; other site 448385018960 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 448385018961 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 448385018962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385018963 PAS fold; Region: PAS_3; pfam08447 448385018964 putative active site [active] 448385018965 heme pocket [chemical binding]; other site 448385018966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385018967 PAS fold; Region: PAS_3; pfam08447 448385018968 putative active site [active] 448385018969 heme pocket [chemical binding]; other site 448385018970 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385018971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385018972 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 448385018973 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 448385018974 dimerization interface [polypeptide binding]; other site 448385018975 peroxiredoxin; Region: AhpC; TIGR03137 448385018976 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 448385018977 dimer interface [polypeptide binding]; other site 448385018978 decamer (pentamer of dimers) interface [polypeptide binding]; other site 448385018979 catalytic triad [active] 448385018980 peroxidatic and resolving cysteines [active] 448385018981 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 448385018982 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 448385018983 catalytic residue [active] 448385018984 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 448385018985 catalytic residues [active] 448385018986 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385018987 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385018988 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385018989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385018990 dimerization interface [polypeptide binding]; other site 448385018991 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 448385018992 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385018993 putative C-terminal domain interface [polypeptide binding]; other site 448385018994 putative GSH binding site (G-site) [chemical binding]; other site 448385018995 putative dimer interface [polypeptide binding]; other site 448385018996 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 448385018997 putative N-terminal domain interface [polypeptide binding]; other site 448385018998 putative dimer interface [polypeptide binding]; other site 448385018999 putative substrate binding pocket (H-site) [chemical binding]; other site 448385019000 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 448385019001 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 448385019002 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 448385019003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019004 dimer interface [polypeptide binding]; other site 448385019005 phosphorylation site [posttranslational modification] 448385019006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385019007 ATP binding site [chemical binding]; other site 448385019008 Mg2+ binding site [ion binding]; other site 448385019009 G-X-G motif; other site 448385019010 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385019011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019012 active site 448385019013 phosphorylation site [posttranslational modification] 448385019014 intermolecular recognition site; other site 448385019015 dimerization interface [polypeptide binding]; other site 448385019016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019017 Walker A motif; other site 448385019018 ATP binding site [chemical binding]; other site 448385019019 Walker B motif; other site 448385019020 arginine finger; other site 448385019021 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385019022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019023 active site 448385019024 phosphorylation site [posttranslational modification] 448385019025 intermolecular recognition site; other site 448385019026 dimerization interface [polypeptide binding]; other site 448385019027 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 448385019028 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 448385019029 iron-sulfur cluster [ion binding]; other site 448385019030 [2Fe-2S] cluster binding site [ion binding]; other site 448385019031 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385019032 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385019033 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385019034 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 448385019035 Syntrophus aciditrophicus Cys-Xaa-Xaa-Xaa repeat radical SAM target protein; Region: Syntroph_Cxxx; TIGR04117 448385019036 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 448385019037 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 448385019038 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385019039 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 448385019040 active site 448385019041 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 448385019042 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 448385019043 active site 448385019044 Zn binding site [ion binding]; other site 448385019045 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 448385019046 PilZ domain; Region: PilZ; pfam07238 448385019047 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 448385019048 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 448385019049 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 448385019050 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 448385019051 Phosphoesterase family; Region: Phosphoesterase; pfam04185 448385019052 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 448385019053 RHS Repeat; Region: RHS_repeat; pfam05593 448385019054 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385019055 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385019056 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385019057 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 448385019058 ZU5 domain; Region: ZU5; cl02517 448385019059 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385019060 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 448385019061 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385019062 RHS Repeat; Region: RHS_repeat; pfam05593 448385019063 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385019064 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385019065 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385019066 active site 448385019067 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385019068 cyclase homology domain; Region: CHD; cd07302 448385019069 nucleotidyl binding site; other site 448385019070 metal binding site [ion binding]; metal-binding site 448385019071 dimer interface [polypeptide binding]; other site 448385019072 Phosphotransferase enzyme family; Region: APH; pfam01636 448385019073 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385019074 active site 448385019075 ATP binding site [chemical binding]; other site 448385019076 substrate binding site [chemical binding]; other site 448385019077 H+ Antiporter protein; Region: 2A0121; TIGR00900 448385019078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 448385019079 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 448385019080 Ligand binding site; other site 448385019081 Putative Catalytic site; other site 448385019082 DXD motif; other site 448385019083 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 448385019084 active site 448385019085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019087 active site 448385019088 ATP binding site [chemical binding]; other site 448385019089 substrate binding site [chemical binding]; other site 448385019090 activation loop (A-loop); other site 448385019091 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 448385019092 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 448385019093 Amidohydrolase; Region: Amidohydro_2; pfam04909 448385019094 FecR protein; Region: FecR; pfam04773 448385019095 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385019096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385019098 DNA binding residues [nucleotide binding] 448385019099 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 448385019100 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385019101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019102 Walker A/P-loop; other site 448385019103 ATP binding site [chemical binding]; other site 448385019104 Q-loop/lid; other site 448385019105 ABC transporter signature motif; other site 448385019106 Walker B; other site 448385019107 D-loop; other site 448385019108 H-loop/switch region; other site 448385019109 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 448385019110 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 448385019111 active site 448385019112 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 448385019113 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 448385019114 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385019115 active site 448385019116 substrate binding site [chemical binding]; other site 448385019117 ATP binding site [chemical binding]; other site 448385019118 Phosphotransferase enzyme family; Region: APH; pfam01636 448385019119 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 448385019120 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385019121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385019122 NAD(P) binding site [chemical binding]; other site 448385019123 active site 448385019124 Deoxyhypusine synthase; Region: DS; cl00826 448385019125 Cytochrome C biogenesis protein; Region: CcmH; cl01179 448385019126 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 448385019127 RF-1 domain; Region: RF-1; cl17422 448385019128 hypothetical protein; Reviewed; Region: PRK09588 448385019129 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 448385019130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019131 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385019132 Walker A motif; other site 448385019133 ATP binding site [chemical binding]; other site 448385019134 Walker B motif; other site 448385019135 arginine finger; other site 448385019136 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385019137 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 448385019138 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385019139 NAD binding site [chemical binding]; other site 448385019140 catalytic Zn binding site [ion binding]; other site 448385019141 structural Zn binding site [ion binding]; other site 448385019142 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 448385019143 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 448385019144 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 448385019145 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 448385019146 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 448385019147 PAS fold; Region: PAS_4; pfam08448 448385019148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019149 heme pocket [chemical binding]; other site 448385019150 putative active site [active] 448385019151 PAS fold; Region: PAS_4; pfam08448 448385019152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019153 putative active site [active] 448385019154 heme pocket [chemical binding]; other site 448385019155 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385019156 Putative cyclase; Region: Cyclase; pfam04199 448385019157 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 448385019158 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 448385019159 putative active site [active] 448385019160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385019161 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385019162 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385019163 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 448385019164 active site 448385019165 catalytic triad [active] 448385019166 oxyanion hole [active] 448385019167 hypothetical protein; Provisional; Region: PRK06126 448385019168 hypothetical protein; Provisional; Region: PRK07236 448385019169 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385019170 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385019171 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 448385019172 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 448385019173 Cytochrome c; Region: Cytochrom_C; pfam00034 448385019174 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 448385019175 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 448385019176 Catalytic site; other site 448385019177 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 448385019178 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 448385019179 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 448385019180 nucleophilic elbow; other site 448385019181 catalytic triad [active] 448385019182 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 448385019183 active site flap/lid [active] 448385019184 nucleophilic elbow; other site 448385019185 catalytic triad [active] 448385019186 FecR protein; Region: FecR; pfam04773 448385019187 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 448385019188 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 448385019189 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385019190 metal ion-dependent adhesion site (MIDAS); other site 448385019191 TPR repeat; Region: TPR_11; pfam13414 448385019192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385019193 binding surface 448385019194 TPR motif; other site 448385019195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385019196 putative active site [active] 448385019197 Dienelactone hydrolase family; Region: DLH; pfam01738 448385019198 Response regulator receiver domain; Region: Response_reg; pfam00072 448385019199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019200 active site 448385019201 phosphorylation site [posttranslational modification] 448385019202 intermolecular recognition site; other site 448385019203 dimerization interface [polypeptide binding]; other site 448385019204 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 448385019205 active site 448385019206 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases; Region: PLPDE_III_ODC_DapDC_like_1; cd06836 448385019207 dimer interface [polypeptide binding]; other site 448385019208 active site 448385019209 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 448385019210 catalytic residues [active] 448385019211 substrate binding site [chemical binding]; other site 448385019212 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 448385019213 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 448385019214 putative active site [active] 448385019215 putative metal binding site [ion binding]; other site 448385019216 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 448385019217 DinB superfamily; Region: DinB_2; pfam12867 448385019218 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 448385019219 active site 448385019220 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 448385019221 Prephenate dehydratase; Region: PDT; pfam00800 448385019222 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 448385019223 putative L-Phe binding site [chemical binding]; other site 448385019224 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385019225 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385019226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385019227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385019228 non-specific DNA binding site [nucleotide binding]; other site 448385019229 salt bridge; other site 448385019230 sequence-specific DNA binding site [nucleotide binding]; other site 448385019231 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 448385019232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385019233 ATP binding site [chemical binding]; other site 448385019234 putative Mg++ binding site [ion binding]; other site 448385019235 helicase superfamily c-terminal domain; Region: HELICc; smart00490 448385019236 Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990 448385019237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019239 active site 448385019240 ATP binding site [chemical binding]; other site 448385019241 substrate binding site [chemical binding]; other site 448385019242 activation loop (A-loop); other site 448385019243 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 448385019244 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 448385019245 intersubunit interface [polypeptide binding]; other site 448385019246 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 448385019247 Phosphopantetheine attachment site; Region: PP-binding; cl09936 448385019248 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 448385019249 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 448385019250 acyl-activating enzyme (AAE) consensus motif; other site 448385019251 active site 448385019252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385019253 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 448385019254 putative substrate translocation pore; other site 448385019255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385019256 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 448385019257 active site 448385019258 motif I; other site 448385019259 motif II; other site 448385019260 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385019261 putative active site [active] 448385019262 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 448385019263 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385019264 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385019265 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 448385019266 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385019267 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385019268 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385019269 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385019270 FecR protein; Region: FecR; pfam04773 448385019271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019272 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385019273 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 448385019274 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385019275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385019276 dimer interface [polypeptide binding]; other site 448385019277 conserved gate region; other site 448385019278 ABC-ATPase subunit interface; other site 448385019279 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 448385019280 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 448385019281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019282 Walker A/P-loop; other site 448385019283 ATP binding site [chemical binding]; other site 448385019284 Q-loop/lid; other site 448385019285 ABC transporter signature motif; other site 448385019286 Walker B; other site 448385019287 D-loop; other site 448385019288 H-loop/switch region; other site 448385019289 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 448385019290 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385019291 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 448385019292 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 448385019293 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385019294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385019295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385019296 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 448385019297 transglutaminase; Provisional; Region: tgl; PRK03187 448385019298 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 448385019299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385019300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019301 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 448385019302 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 448385019303 RNA methyltransferase, RsmE family; Region: TIGR00046 448385019304 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 448385019305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385019306 S-adenosylmethionine binding site [chemical binding]; other site 448385019307 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 448385019308 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 448385019309 active site 448385019310 metal binding site [ion binding]; metal-binding site 448385019311 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 448385019312 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 448385019313 ligand binding site; other site 448385019314 oligomer interface; other site 448385019315 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 448385019316 dimer interface [polypeptide binding]; other site 448385019317 N-terminal domain interface [polypeptide binding]; other site 448385019318 sulfate 1 binding site; other site 448385019319 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 448385019320 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 448385019321 Cl- selectivity filter; other site 448385019322 Cl- binding residues [ion binding]; other site 448385019323 pore gating glutamate residue; other site 448385019324 dimer interface [polypeptide binding]; other site 448385019325 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 448385019326 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385019327 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019328 active site 448385019329 phosphorylation site [posttranslational modification] 448385019330 intermolecular recognition site; other site 448385019331 dimerization interface [polypeptide binding]; other site 448385019332 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 448385019333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 448385019334 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 448385019335 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 448385019336 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 448385019337 putative dimer interface [polypeptide binding]; other site 448385019338 putative active site [active] 448385019339 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385019340 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 448385019341 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385019342 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 448385019343 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 448385019344 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 448385019345 catalytic triad [active] 448385019346 putative acyltransferase; Provisional; Region: PRK05790 448385019347 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 448385019348 dimer interface [polypeptide binding]; other site 448385019349 active site 448385019350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385019351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385019352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019353 dimer interface [polypeptide binding]; other site 448385019354 phosphorylation site [posttranslational modification] 448385019355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385019356 ATP binding site [chemical binding]; other site 448385019357 Mg2+ binding site [ion binding]; other site 448385019358 G-X-G motif; other site 448385019359 MbtH-like protein; Region: MbtH; cl01279 448385019360 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 448385019361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385019362 Coenzyme A binding pocket [chemical binding]; other site 448385019363 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 448385019364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385019365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385019366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 448385019367 dimerization interface [polypeptide binding]; other site 448385019368 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019369 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019370 active site 448385019371 ATP binding site [chemical binding]; other site 448385019372 substrate binding site [chemical binding]; other site 448385019373 activation loop (A-loop); other site 448385019374 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 448385019375 Right handed beta helix region; Region: Beta_helix; pfam13229 448385019376 Right handed beta helix region; Region: Beta_helix; pfam13229 448385019377 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385019378 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385019379 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385019380 structural tetrad; other site 448385019381 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385019382 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385019383 structural tetrad; other site 448385019384 AAA ATPase domain; Region: AAA_16; pfam13191 448385019385 Walker A motif; other site 448385019386 ATP binding site [chemical binding]; other site 448385019387 Domain of unknown function DUF87; Region: DUF87; pfam01935 448385019388 AAA-like domain; Region: AAA_10; pfam12846 448385019389 TfuA-like protein; Region: TfuA; pfam07812 448385019390 Uncharacterized conserved protein [Function unknown]; Region: COG1944 448385019391 YcaO-like family; Region: YcaO; pfam02624 448385019392 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019394 active site 448385019395 ATP binding site [chemical binding]; other site 448385019396 substrate binding site [chemical binding]; other site 448385019397 activation loop (A-loop); other site 448385019398 AAA ATPase domain; Region: AAA_16; pfam13191 448385019399 Predicted ATPase [General function prediction only]; Region: COG3899 448385019400 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385019401 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385019402 phosphopeptide binding site; other site 448385019403 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385019404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019405 Walker A motif; other site 448385019406 ATP binding site [chemical binding]; other site 448385019407 Walker B motif; other site 448385019408 arginine finger; other site 448385019409 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385019410 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 448385019411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019413 active site 448385019414 ATP binding site [chemical binding]; other site 448385019415 substrate binding site [chemical binding]; other site 448385019416 activation loop (A-loop); other site 448385019417 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 448385019418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019419 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385019420 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK14810 448385019421 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 448385019422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 448385019423 TrkA-N domain; Region: TrkA_N; pfam02254 448385019424 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 448385019425 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 448385019426 PAS fold; Region: PAS_4; pfam08448 448385019427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019428 putative active site [active] 448385019429 heme pocket [chemical binding]; other site 448385019430 PAS domain; Region: PAS; smart00091 448385019431 PAS fold; Region: PAS_4; pfam08448 448385019432 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385019433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385019434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385019435 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385019436 putative effector binding pocket; other site 448385019437 dimerization interface [polypeptide binding]; other site 448385019438 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 448385019439 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385019440 NADP binding site [chemical binding]; other site 448385019441 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 448385019442 putative FMN binding site [chemical binding]; other site 448385019443 NADPH bind site [chemical binding]; other site 448385019444 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 448385019445 YcaO-like family; Region: YcaO; pfam02624 448385019446 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 448385019447 Transposase IS200 like; Region: Y1_Tnp; cl00848 448385019448 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 448385019449 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 448385019450 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 448385019451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019453 active site 448385019454 ATP binding site [chemical binding]; other site 448385019455 substrate binding site [chemical binding]; other site 448385019456 activation loop (A-loop); other site 448385019457 Syntrophus aciditrophicus Cys-Xaa-Xaa-Xaa repeat radical SAM target protein; Region: Syntroph_Cxxx; TIGR04117 448385019458 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 448385019459 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 448385019460 active site 448385019461 catalytic triad [active] 448385019462 oxyanion hole [active] 448385019463 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 448385019464 active site 448385019465 catalytic triad [active] 448385019466 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385019467 AAA ATPase domain; Region: AAA_16; pfam13191 448385019468 Phosphoesterase family; Region: Phosphoesterase; pfam04185 448385019469 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 448385019470 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 448385019471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019472 Walker A motif; other site 448385019473 ATP binding site [chemical binding]; other site 448385019474 Walker B motif; other site 448385019475 arginine finger; other site 448385019476 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 448385019477 hypothetical protein; Reviewed; Region: PRK09588 448385019478 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 448385019479 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 448385019480 putative active site [active] 448385019481 ornithine carbamoyltransferase; Provisional; Region: PRK00779 448385019482 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 448385019483 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 448385019484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019485 putative active site [active] 448385019486 PAS fold; Region: PAS_3; pfam08447 448385019487 heme pocket [chemical binding]; other site 448385019488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019489 putative active site [active] 448385019490 PAS fold; Region: PAS_3; pfam08447 448385019491 heme pocket [chemical binding]; other site 448385019492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385019493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019494 dimer interface [polypeptide binding]; other site 448385019495 phosphorylation site [posttranslational modification] 448385019496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385019497 ATP binding site [chemical binding]; other site 448385019498 Mg2+ binding site [ion binding]; other site 448385019499 G-X-G motif; other site 448385019500 Response regulator receiver domain; Region: Response_reg; pfam00072 448385019501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019502 active site 448385019503 phosphorylation site [posttranslational modification] 448385019504 intermolecular recognition site; other site 448385019505 dimerization interface [polypeptide binding]; other site 448385019506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019507 Walker A motif; other site 448385019508 ATP binding site [chemical binding]; other site 448385019509 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 448385019510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019511 Walker A motif; other site 448385019512 ATP binding site [chemical binding]; other site 448385019513 Walker B motif; other site 448385019514 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 448385019515 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 448385019516 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 448385019517 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 448385019518 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 448385019519 active site 448385019520 metal binding site [ion binding]; metal-binding site 448385019521 DNA binding site [nucleotide binding] 448385019522 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385019523 Cytochrome P450; Region: p450; cl12078 448385019524 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385019525 putative active site [active] 448385019526 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 448385019527 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 448385019528 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 448385019529 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 448385019530 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 448385019531 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 448385019532 catalytic site [active] 448385019533 active site 448385019534 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 448385019535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019536 Walker A/P-loop; other site 448385019537 ATP binding site [chemical binding]; other site 448385019538 ABC transporter; Region: ABC_tran; pfam00005 448385019539 Q-loop/lid; other site 448385019540 ABC transporter signature motif; other site 448385019541 Walker B; other site 448385019542 D-loop; other site 448385019543 H-loop/switch region; other site 448385019544 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 448385019545 putative active site [active] 448385019546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019547 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 448385019548 Walker A/P-loop; other site 448385019549 ATP binding site [chemical binding]; other site 448385019550 Q-loop/lid; other site 448385019551 ABC transporter signature motif; other site 448385019552 Walker B; other site 448385019553 D-loop; other site 448385019554 H-loop/switch region; other site 448385019555 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 448385019556 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385019557 Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559 448385019558 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 448385019559 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385019560 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 448385019561 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385019562 AAA domain; Region: AAA_23; pfam13476 448385019563 Predicted ATPase [General function prediction only]; Region: COG4637 448385019564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019565 Walker A/P-loop; other site 448385019566 ATP binding site [chemical binding]; other site 448385019567 Q-loop/lid; other site 448385019568 Domain of unknown function (DUF202); Region: DUF202; cl09954 448385019569 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 448385019570 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 448385019571 Moco binding site; other site 448385019572 metal coordination site [ion binding]; other site 448385019573 Dihydroneopterin aldolase; Region: FolB; pfam02152 448385019574 active site 448385019575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385019576 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385019577 ligand binding site [chemical binding]; other site 448385019578 flexible hinge region; other site 448385019579 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 448385019580 putative switch regulator; other site 448385019581 non-specific DNA interactions [nucleotide binding]; other site 448385019582 DNA binding site [nucleotide binding] 448385019583 sequence specific DNA binding site [nucleotide binding]; other site 448385019584 putative cAMP binding site [chemical binding]; other site 448385019585 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 448385019586 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 448385019587 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 448385019588 FAD binding pocket [chemical binding]; other site 448385019589 FAD binding motif [chemical binding]; other site 448385019590 phosphate binding motif [ion binding]; other site 448385019591 beta-alpha-beta structure motif; other site 448385019592 NAD binding pocket [chemical binding]; other site 448385019593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385019594 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385019595 metal ion-dependent adhesion site (MIDAS); other site 448385019596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385019597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385019598 sequence-specific DNA binding site [nucleotide binding]; other site 448385019599 salt bridge; other site 448385019600 Cupin domain; Region: Cupin_2; pfam07883 448385019601 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019602 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019603 active site 448385019604 ATP binding site [chemical binding]; other site 448385019605 substrate binding site [chemical binding]; other site 448385019606 activation loop (A-loop); other site 448385019607 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019608 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019609 active site 448385019610 ATP binding site [chemical binding]; other site 448385019611 substrate binding site [chemical binding]; other site 448385019612 activation loop (A-loop); other site 448385019613 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385019614 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385019615 ligand binding site [chemical binding]; other site 448385019616 flexible hinge region; other site 448385019617 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385019618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385019619 NAD(P) binding site [chemical binding]; other site 448385019620 active site 448385019621 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385019622 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 448385019623 active site 448385019624 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 448385019625 metal binding site 2 [ion binding]; metal-binding site 448385019626 putative DNA binding helix; other site 448385019627 metal binding site 1 [ion binding]; metal-binding site 448385019628 dimer interface [polypeptide binding]; other site 448385019629 structural Zn2+ binding site [ion binding]; other site 448385019630 Predicted permease; Region: DUF318; cl17795 448385019631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019633 active site 448385019634 ATP binding site [chemical binding]; other site 448385019635 substrate binding site [chemical binding]; other site 448385019636 activation loop (A-loop); other site 448385019637 glutamine synthetase, type I; Region: GlnA; TIGR00653 448385019638 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 448385019639 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 448385019640 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 448385019641 Nitrogen regulatory protein P-II; Region: P-II; smart00938 448385019642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019643 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019644 active site 448385019645 ATP binding site [chemical binding]; other site 448385019646 substrate binding site [chemical binding]; other site 448385019647 activation loop (A-loop); other site 448385019648 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 448385019649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385019650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385019651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019652 dimer interface [polypeptide binding]; other site 448385019653 phosphorylation site [posttranslational modification] 448385019654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385019655 ATP binding site [chemical binding]; other site 448385019656 Mg2+ binding site [ion binding]; other site 448385019657 G-X-G motif; other site 448385019658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385019659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019660 dimer interface [polypeptide binding]; other site 448385019661 phosphorylation site [posttranslational modification] 448385019662 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 448385019663 ATP binding site [chemical binding]; other site 448385019664 Mg2+ binding site [ion binding]; other site 448385019665 G-X-G motif; other site 448385019666 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 448385019667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019668 Walker A motif; other site 448385019669 ATP binding site [chemical binding]; other site 448385019670 Walker B motif; other site 448385019671 arginine finger; other site 448385019672 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 448385019673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019674 Response regulator receiver domain; Region: Response_reg; pfam00072 448385019675 active site 448385019676 phosphorylation site [posttranslational modification] 448385019677 intermolecular recognition site; other site 448385019678 dimerization interface [polypeptide binding]; other site 448385019679 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385019680 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385019681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019682 PAS domain; Region: PAS_9; pfam13426 448385019683 putative active site [active] 448385019684 heme pocket [chemical binding]; other site 448385019685 PAS domain S-box; Region: sensory_box; TIGR00229 448385019686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385019687 putative active site [active] 448385019688 heme pocket [chemical binding]; other site 448385019689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019690 dimer interface [polypeptide binding]; other site 448385019691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385019692 dimer interface [polypeptide binding]; other site 448385019693 phosphorylation site [posttranslational modification] 448385019694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385019695 ATP binding site [chemical binding]; other site 448385019696 Mg2+ binding site [ion binding]; other site 448385019697 G-X-G motif; other site 448385019698 Putative zinc-finger; Region: zf-HC2; pfam13490 448385019699 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 448385019700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385019702 DNA binding residues [nucleotide binding] 448385019703 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 448385019704 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385019705 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385019706 protein binding site [polypeptide binding]; other site 448385019707 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 448385019708 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 448385019709 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385019710 multidrug resistance protein MdtN; Provisional; Region: PRK10476 448385019711 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385019712 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385019713 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385019714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385019715 Walker A/P-loop; other site 448385019716 ATP binding site [chemical binding]; other site 448385019717 Q-loop/lid; other site 448385019718 ABC transporter signature motif; other site 448385019719 Walker B; other site 448385019720 D-loop; other site 448385019721 H-loop/switch region; other site 448385019722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385019723 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385019724 FtsX-like permease family; Region: FtsX; pfam02687 448385019725 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385019726 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385019727 FtsX-like permease family; Region: FtsX; pfam02687 448385019728 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 448385019729 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 448385019730 RNA binding site [nucleotide binding]; other site 448385019731 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 448385019732 RNA binding site [nucleotide binding]; other site 448385019733 domain interface; other site 448385019734 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 448385019735 RNA binding site [nucleotide binding]; other site 448385019736 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385019737 RNA binding site [nucleotide binding]; other site 448385019738 Domain of unknown function DUF59; Region: DUF59; pfam01883 448385019739 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 448385019740 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 448385019741 Walker A motif; other site 448385019742 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385019743 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385019744 catalytic residues [active] 448385019745 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385019746 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385019747 catalytic residues [active] 448385019748 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 448385019749 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 448385019750 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385019751 Di-iron ligands [ion binding]; other site 448385019752 CTP synthetase; Validated; Region: pyrG; PRK05380 448385019753 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 448385019754 Catalytic site [active] 448385019755 active site 448385019756 UTP binding site [chemical binding]; other site 448385019757 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 448385019758 active site 448385019759 putative oxyanion hole; other site 448385019760 catalytic triad [active] 448385019761 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385019762 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 448385019763 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 448385019764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385019765 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 448385019766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385019767 DNA binding residues [nucleotide binding] 448385019768 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 448385019769 23S rRNA binding site [nucleotide binding]; other site 448385019770 L21 binding site [polypeptide binding]; other site 448385019771 L13 binding site [polypeptide binding]; other site 448385019772 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 448385019773 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 448385019774 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385019775 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385019776 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 448385019777 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 448385019778 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 448385019779 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 448385019780 G1 box; other site 448385019781 GTP/Mg2+ binding site [chemical binding]; other site 448385019782 G2 box; other site 448385019783 Switch I region; other site 448385019784 G3 box; other site 448385019785 Switch II region; other site 448385019786 G4 box; other site 448385019787 G5 box; other site 448385019788 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 448385019789 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 448385019790 active site 448385019791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 448385019792 dimer interface [polypeptide binding]; other site 448385019793 substrate binding site [chemical binding]; other site 448385019794 catalytic residues [active] 448385019795 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 448385019796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385019797 Coenzyme A binding pocket [chemical binding]; other site 448385019798 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 448385019799 G1 box; other site 448385019800 GTP/Mg2+ binding site [chemical binding]; other site 448385019801 G2 box; other site 448385019802 G3 box; other site 448385019803 Switch II region; other site 448385019804 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 448385019805 G4 box; other site 448385019806 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 448385019807 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385019808 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 448385019809 active site 448385019810 metal binding site [ion binding]; metal-binding site 448385019811 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 448385019812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385019813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385019814 S-adenosylmethionine binding site [chemical binding]; other site 448385019815 Domain of unknown function (DUF929); Region: DUF929; pfam06053 448385019816 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 448385019817 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 448385019818 putative nucleotide binding site [chemical binding]; other site 448385019819 uridine monophosphate binding site [chemical binding]; other site 448385019820 homohexameric interface [polypeptide binding]; other site 448385019821 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 448385019822 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 448385019823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385019824 FeS/SAM binding site; other site 448385019825 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 448385019826 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019827 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019828 active site 448385019829 ATP binding site [chemical binding]; other site 448385019830 substrate binding site [chemical binding]; other site 448385019831 activation loop (A-loop); other site 448385019832 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385019833 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385019834 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385019835 RNA binding site [nucleotide binding]; other site 448385019836 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 448385019837 homodimer interface [polypeptide binding]; other site 448385019838 oligonucleotide binding site [chemical binding]; other site 448385019839 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 448385019840 PilZ domain; Region: PilZ; cl01260 448385019841 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 448385019842 Lumazine binding domain; Region: Lum_binding; pfam00677 448385019843 Lumazine binding domain; Region: Lum_binding; pfam00677 448385019844 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 448385019845 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 448385019846 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 448385019847 dimerization interface [polypeptide binding]; other site 448385019848 active site 448385019849 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 448385019850 homopentamer interface [polypeptide binding]; other site 448385019851 active site 448385019852 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 448385019853 putative RNA binding site [nucleotide binding]; other site 448385019854 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 448385019855 MutS domain III; Region: MutS_III; pfam05192 448385019856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385019857 Walker A/P-loop; other site 448385019858 ATP binding site [chemical binding]; other site 448385019859 Q-loop/lid; other site 448385019860 ABC transporter signature motif; other site 448385019861 Walker B; other site 448385019862 D-loop; other site 448385019863 H-loop/switch region; other site 448385019864 Smr domain; Region: Smr; pfam01713 448385019865 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385019866 phosphopeptide binding site; other site 448385019867 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385019868 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385019869 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 448385019870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019871 Walker A motif; other site 448385019872 ATP binding site [chemical binding]; other site 448385019873 Walker B motif; other site 448385019874 arginine finger; other site 448385019875 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385019876 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 448385019877 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 448385019878 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 448385019879 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 448385019880 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 448385019881 Catalytic site [active] 448385019882 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 448385019883 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 448385019884 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 448385019885 NAD(P) binding site [chemical binding]; other site 448385019886 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 448385019887 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 448385019888 substrate-cofactor binding pocket; other site 448385019889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385019890 catalytic residue [active] 448385019891 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 448385019892 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385019893 putative catalytic site [active] 448385019894 putative metal binding site [ion binding]; other site 448385019895 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385019896 putative catalytic site [active] 448385019897 putative phosphate binding site [ion binding]; other site 448385019898 putative phosphate binding site [ion binding]; other site 448385019899 putative metal binding site [ion binding]; other site 448385019900 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 448385019901 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 448385019902 putative active site [active] 448385019903 putative metal binding site [ion binding]; other site 448385019904 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 448385019905 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385019906 active site 448385019907 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385019908 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 448385019909 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 448385019910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385019911 Walker A motif; other site 448385019912 ATP binding site [chemical binding]; other site 448385019913 Walker B motif; other site 448385019914 arginine finger; other site 448385019915 Peptidase family M41; Region: Peptidase_M41; pfam01434 448385019916 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 448385019917 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 448385019918 Ligand Binding Site [chemical binding]; other site 448385019919 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 448385019920 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 448385019921 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385019922 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385019923 active site 448385019924 ATP binding site [chemical binding]; other site 448385019925 substrate binding site [chemical binding]; other site 448385019926 activation loop (A-loop); other site 448385019927 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 448385019928 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 448385019929 Ligand Binding Site [chemical binding]; other site 448385019930 Response regulator receiver domain; Region: Response_reg; pfam00072 448385019931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385019932 active site 448385019933 phosphorylation site [posttranslational modification] 448385019934 intermolecular recognition site; other site 448385019935 dimerization interface [polypeptide binding]; other site 448385019936 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385019937 Double zinc ribbon; Region: DZR; pfam12773 448385019938 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 448385019939 DNA methylase; Region: N6_N4_Mtase; pfam01555 448385019940 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 448385019941 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 448385019942 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385019943 catalytic loop [active] 448385019944 iron binding site [ion binding]; other site 448385019945 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 448385019946 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 448385019947 tetramer interface [polypeptide binding]; other site 448385019948 active site 448385019949 Mg2+/Mn2+ binding site [ion binding]; other site 448385019950 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 448385019951 active site 448385019952 metal-binding site 448385019953 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 448385019954 PYR/PP interface [polypeptide binding]; other site 448385019955 dimer interface [polypeptide binding]; other site 448385019956 TPP binding site [chemical binding]; other site 448385019957 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 448385019958 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 448385019959 TPP-binding site [chemical binding]; other site 448385019960 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 448385019961 active site 448385019962 metal-binding site 448385019963 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 448385019964 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385019965 protein binding site [polypeptide binding]; other site 448385019966 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 448385019967 S-adenosylmethionine synthetase; Validated; Region: PRK05250 448385019968 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 448385019969 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 448385019970 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 448385019971 B3/4 domain; Region: B3_4; pfam03483 448385019972 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 448385019973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 448385019974 Family description; Region: VCBS; pfam13517 448385019975 Family description; Region: VCBS; pfam13517 448385019976 Family description; Region: VCBS; pfam13517 448385019977 Family description; Region: VCBS; pfam13517 448385019978 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 448385019979 Chain length determinant protein; Region: Wzz; pfam02706 448385019980 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 448385019981 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 448385019982 putative glycosyl transferase; Provisional; Region: PRK10307 448385019983 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 448385019984 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 448385019985 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385019986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385019987 S-adenosylmethionine binding site [chemical binding]; other site 448385019988 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 448385019989 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 448385019990 Mg++ binding site [ion binding]; other site 448385019991 putative catalytic motif [active] 448385019992 substrate binding site [chemical binding]; other site 448385019993 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385019994 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385019995 S-adenosylmethionine binding site [chemical binding]; other site 448385019996 putative acyl transferase; Provisional; Region: PRK10191 448385019997 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 448385019998 trimer interface [polypeptide binding]; other site 448385019999 active site 448385020000 substrate binding site [chemical binding]; other site 448385020001 CoA binding site [chemical binding]; other site 448385020002 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385020003 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385020004 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 448385020005 DNA binding residues [nucleotide binding] 448385020006 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 448385020007 cysteine desulfurase; Provisional; Region: PRK14012 448385020008 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 448385020009 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385020010 catalytic residue [active] 448385020011 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 448385020012 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 448385020013 trimerization site [polypeptide binding]; other site 448385020014 active site 448385020015 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 448385020016 co-chaperone HscB; Provisional; Region: hscB; PRK03578 448385020017 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385020018 HSP70 interaction site [polypeptide binding]; other site 448385020019 chaperone protein HscA; Provisional; Region: hscA; PRK05183 448385020020 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 448385020021 nucleotide binding site [chemical binding]; other site 448385020022 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385020023 SBD interface [polypeptide binding]; other site 448385020024 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 448385020025 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 448385020026 catalytic loop [active] 448385020027 iron binding site [ion binding]; other site 448385020028 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 448385020029 GTP-binding protein YchF; Reviewed; Region: PRK09601 448385020030 YchF GTPase; Region: YchF; cd01900 448385020031 G1 box; other site 448385020032 GTP/Mg2+ binding site [chemical binding]; other site 448385020033 Switch I region; other site 448385020034 G2 box; other site 448385020035 Switch II region; other site 448385020036 G3 box; other site 448385020037 G4 box; other site 448385020038 G5 box; other site 448385020039 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 448385020040 Formyl transferase catalytic core domain found in a group of proteins with unknown functions; Region: FMT_core_like_3; cd08653 448385020041 putative active site [active] 448385020042 putative cosubstrate binding site; other site 448385020043 putative substrate binding site [chemical binding]; other site 448385020044 catalytic site [active] 448385020045 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 448385020046 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 448385020047 inhibitor-cofactor binding pocket; inhibition site 448385020048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385020049 catalytic residue [active] 448385020050 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 448385020051 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 448385020052 putative trimer interface [polypeptide binding]; other site 448385020053 putative active site [active] 448385020054 putative substrate binding site [chemical binding]; other site 448385020055 putative CoA binding site [chemical binding]; other site 448385020056 Preprotein translocase SecG subunit; Region: SecG; pfam03840 448385020057 triosephosphate isomerase; Provisional; Region: PRK14567 448385020058 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 448385020059 substrate binding site [chemical binding]; other site 448385020060 dimer interface [polypeptide binding]; other site 448385020061 catalytic triad [active] 448385020062 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 448385020063 Phosphoglycerate kinase; Region: PGK; pfam00162 448385020064 substrate binding site [chemical binding]; other site 448385020065 hinge regions; other site 448385020066 ADP binding site [chemical binding]; other site 448385020067 catalytic site [active] 448385020068 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 448385020069 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 448385020070 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 448385020071 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 448385020072 catalytic residues [active] 448385020073 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385020074 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 448385020075 Ligand binding site; other site 448385020076 Putative Catalytic site; other site 448385020077 DXD motif; other site 448385020078 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020079 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020080 active site 448385020081 ATP binding site [chemical binding]; other site 448385020082 substrate binding site [chemical binding]; other site 448385020083 activation loop (A-loop); other site 448385020084 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 448385020085 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 448385020086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385020087 putative active site [active] 448385020088 heme pocket [chemical binding]; other site 448385020089 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385020090 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 448385020091 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 448385020092 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 448385020093 phosphate binding site [ion binding]; other site 448385020094 putative substrate binding pocket [chemical binding]; other site 448385020095 dimer interface [polypeptide binding]; other site 448385020096 DNA methylase; Region: N6_N4_Mtase; cl17433 448385020097 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 448385020098 MAEBL; Provisional; Region: PTZ00121 448385020099 TPR repeat; Region: TPR_11; pfam13414 448385020100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020101 binding surface 448385020102 TPR motif; other site 448385020103 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020104 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020105 active site 448385020106 ATP binding site [chemical binding]; other site 448385020107 substrate binding site [chemical binding]; other site 448385020108 activation loop (A-loop); other site 448385020109 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 448385020110 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 448385020111 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385020112 Walker A/P-loop; other site 448385020113 ATP binding site [chemical binding]; other site 448385020114 Q-loop/lid; other site 448385020115 ABC transporter signature motif; other site 448385020116 Walker B; other site 448385020117 D-loop; other site 448385020118 H-loop/switch region; other site 448385020119 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385020120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385020121 Walker A motif; other site 448385020122 ATP binding site [chemical binding]; other site 448385020123 Walker B motif; other site 448385020124 arginine finger; other site 448385020125 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385020126 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385020127 dimer interface [polypeptide binding]; other site 448385020128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385020129 catalytic residue [active] 448385020130 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 448385020131 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 448385020132 Walker A/P-loop; other site 448385020133 ATP binding site [chemical binding]; other site 448385020134 Q-loop/lid; other site 448385020135 ABC transporter signature motif; other site 448385020136 Walker B; other site 448385020137 D-loop; other site 448385020138 H-loop/switch region; other site 448385020139 TOBE-like domain; Region: TOBE_3; pfam12857 448385020140 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385020141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385020142 NAD(P) binding site [chemical binding]; other site 448385020143 active site 448385020144 Uncharacterized conserved protein [Function unknown]; Region: COG2454 448385020145 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020146 substrate binding site [chemical binding]; other site 448385020147 activation loop (A-loop); other site 448385020148 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 448385020149 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 448385020150 Ligand binding site; other site 448385020151 Putative Catalytic site; other site 448385020152 DXD motif; other site 448385020153 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 448385020154 Predicted membrane protein [Function unknown]; Region: COG3463 448385020155 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 448385020156 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385020157 Ligand Binding Site [chemical binding]; other site 448385020158 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 448385020159 hypothetical protein; Validated; Region: PRK00110 448385020160 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 448385020161 Flavoprotein; Region: Flavoprotein; pfam02441 448385020162 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 448385020163 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 448385020164 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 448385020165 active site 448385020166 HIGH motif; other site 448385020167 dimer interface [polypeptide binding]; other site 448385020168 KMSKS motif; other site 448385020169 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 448385020170 VanW like protein; Region: VanW; pfam04294 448385020171 G5 domain; Region: G5; pfam07501 448385020172 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020173 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020174 active site 448385020175 ATP binding site [chemical binding]; other site 448385020176 substrate binding site [chemical binding]; other site 448385020177 activation loop (A-loop); other site 448385020178 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 448385020179 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 448385020180 GIY-YIG motif/motif A; other site 448385020181 active site 448385020182 catalytic site [active] 448385020183 putative DNA binding site [nucleotide binding]; other site 448385020184 metal binding site [ion binding]; metal-binding site 448385020185 UvrB/uvrC motif; Region: UVR; pfam02151 448385020186 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 448385020187 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 448385020188 DNA/RNA-binding repeats in PUR-alpha/beta/gamma and in hypothetical proteins from spirochetes and the Bacteroides-Cytophaga-Flexibacter bacteria; Region: PUR; smart00712 448385020189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 448385020190 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 448385020191 TPR repeat; Region: TPR_11; pfam13414 448385020192 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020193 TPR motif; other site 448385020194 binding surface 448385020195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020196 binding surface 448385020197 TPR motif; other site 448385020198 TPR repeat; Region: TPR_11; pfam13414 448385020199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 448385020200 binding surface 448385020201 TPR motif; other site 448385020202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 448385020203 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385020204 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 448385020205 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 448385020206 23S rRNA interface [nucleotide binding]; other site 448385020207 L3 interface [polypeptide binding]; other site 448385020208 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385020209 dimerization interface [polypeptide binding]; other site 448385020210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 448385020211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385020212 ATP binding site [chemical binding]; other site 448385020213 Mg2+ binding site [ion binding]; other site 448385020214 G-X-G motif; other site 448385020215 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 448385020216 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 448385020217 glutaminase active site [active] 448385020218 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 448385020219 dimer interface [polypeptide binding]; other site 448385020220 active site 448385020221 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 448385020222 dimer interface [polypeptide binding]; other site 448385020223 active site 448385020224 MFS_1 like family; Region: MFS_1_like; pfam12832 448385020225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385020226 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 448385020227 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 448385020228 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 448385020229 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 448385020230 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 448385020231 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 448385020232 active site 448385020233 catalytic residues [active] 448385020234 metal binding site [ion binding]; metal-binding site 448385020235 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 448385020236 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 448385020237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 448385020238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 448385020239 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 448385020240 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 448385020241 HIGH motif; other site 448385020242 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 448385020243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385020244 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385020245 active site 448385020246 KMSKS motif; other site 448385020247 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 448385020248 tRNA binding surface [nucleotide binding]; other site 448385020249 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385020250 active site 448385020251 substrate binding sites [chemical binding]; other site 448385020252 Protein of unknown function (DUF3897); Region: DUF3897; pfam13036 448385020253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 448385020254 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 448385020255 alpha-glucosidase; Provisional; Region: PRK10137 448385020256 quinolinate synthetase; Provisional; Region: PRK09375 448385020257 Protein of unknown function (DUF3634); Region: DUF3634; pfam12321 448385020258 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 448385020259 ABC1 family; Region: ABC1; cl17513 448385020260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020262 active site 448385020263 ATP binding site [chemical binding]; other site 448385020264 substrate binding site [chemical binding]; other site 448385020265 activation loop (A-loop); other site 448385020266 Beta-propeller repeat; Region: SBBP; pfam06739 448385020267 ribonuclease R; Region: RNase_R; TIGR02063 448385020268 RNB domain; Region: RNB; pfam00773 448385020269 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385020270 RNA binding site [nucleotide binding]; other site 448385020271 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385020272 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385020273 phosphopeptide binding site; other site 448385020274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020275 binding surface 448385020276 PEGA domain; Region: PEGA; pfam08308 448385020277 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020278 active site 448385020279 substrate binding site [chemical binding]; other site 448385020280 ATP binding site [chemical binding]; other site 448385020281 activation loop (A-loop); other site 448385020282 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020283 active site 448385020284 ATP binding site [chemical binding]; other site 448385020285 substrate binding site [chemical binding]; other site 448385020286 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020287 activation loop (A-loop); other site 448385020288 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 448385020289 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385020290 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 448385020291 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 448385020292 intersubunit interface [polypeptide binding]; other site 448385020293 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 448385020294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385020295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385020296 NAD(P) binding site [chemical binding]; other site 448385020297 active site 448385020298 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385020299 NAD-dependent deacetylase; Provisional; Region: PRK00481 448385020300 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 448385020301 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385020302 putative active site [active] 448385020303 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385020304 putative active site [active] 448385020305 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 448385020306 Predicted metalloprotease [General function prediction only]; Region: COG2321 448385020307 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 448385020308 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385020309 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020310 active site 448385020311 ATP binding site [chemical binding]; other site 448385020312 substrate binding site [chemical binding]; other site 448385020313 activation loop (A-loop); other site 448385020314 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020315 AAA ATPase domain; Region: AAA_16; pfam13191 448385020316 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385020317 SnoaL-like domain; Region: SnoaL_3; pfam13474 448385020318 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385020319 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385020320 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385020321 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385020322 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385020323 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385020324 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385020325 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385020326 RHS Repeat; Region: RHS_repeat; cl11982 448385020327 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385020328 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385020329 RHS Repeat; Region: RHS_repeat; pfam05593 448385020330 RHS Repeat; Region: RHS_repeat; cl11982 448385020331 RHS Repeat; Region: RHS_repeat; pfam05593 448385020332 RHS Repeat; Region: RHS_repeat; cl11982 448385020333 RHS protein; Region: RHS; pfam03527 448385020334 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385020335 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385020336 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385020337 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385020338 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 448385020339 TrkA-N domain; Region: TrkA_N; pfam02254 448385020340 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 448385020341 PAS fold; Region: PAS_4; pfam08448 448385020342 PAS fold; Region: PAS_4; pfam08448 448385020343 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385020344 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385020345 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 448385020346 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 448385020347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385020348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385020349 Uncharacterized conserved protein [Function unknown]; Region: COG0398 448385020350 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 448385020351 AAA domain; Region: AAA_22; pfam13401 448385020352 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 448385020353 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 448385020354 Hemerythrin-like domain; Region: Hr-like; cd12108 448385020355 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 448385020356 DTW domain; Region: DTW; cl01221 448385020357 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385020358 RNA polymerase Rpc34 subunit; Region: RNA_pol_Rpc34; cl02127 448385020359 2-phosphoglycolate phosphatase, prokaryotic; Region: PGP_bact; TIGR01449 448385020360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385020361 motif I; other site 448385020362 motif II; other site 448385020363 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385020364 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385020365 Penicillinase repressor; Region: Pencillinase_R; cl17580 448385020366 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 448385020367 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 448385020368 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 448385020369 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385020370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385020371 S-adenosylmethionine binding site [chemical binding]; other site 448385020372 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 448385020373 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385020374 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385020375 putative C-terminal domain interface [polypeptide binding]; other site 448385020376 putative GSH binding site (G-site) [chemical binding]; other site 448385020377 putative dimer interface [polypeptide binding]; other site 448385020378 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385020379 N-terminal domain interface [polypeptide binding]; other site 448385020380 DoxX-like family; Region: DoxX_2; pfam13564 448385020381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020382 TPR motif; other site 448385020383 TPR repeat; Region: TPR_11; pfam13414 448385020384 binding surface 448385020385 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385020386 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385020387 Serine hydrolase (FSH1); Region: FSH1; pfam03959 448385020388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385020389 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 448385020390 Predicted transcriptional regulators [Transcription]; Region: COG1733 448385020391 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 448385020392 short chain dehydrogenase; Provisional; Region: PRK06523 448385020393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385020394 NAD(P) binding site [chemical binding]; other site 448385020395 active site 448385020396 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 448385020397 MPN+ (JAMM) motif; other site 448385020398 Zinc-binding site [ion binding]; other site 448385020399 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 448385020400 MPN+ (JAMM) motif; other site 448385020401 Zinc-binding site [ion binding]; other site 448385020402 Protein of unknown function, DUF258; Region: DUF258; pfam03193 448385020403 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 448385020404 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 448385020405 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385020406 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 448385020407 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 448385020408 putative active site [active] 448385020409 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 448385020410 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 448385020411 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385020412 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 448385020413 hypothetical protein; Provisional; Region: PRK07538 448385020414 hypothetical protein; Provisional; Region: PRK07236 448385020415 Ubiquitin-like proteins; Region: UBQ; cl00155 448385020416 charged pocket; other site 448385020417 hydrophobic patch; other site 448385020418 VPS10 domain; Region: VPS10; smart00602 448385020419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385020420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385020421 active site 448385020422 catalytic tetrad [active] 448385020423 AAA domain; Region: AAA_33; pfam13671 448385020424 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 448385020425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385020426 active site 448385020427 motif I; other site 448385020428 motif II; other site 448385020429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385020430 PEGA domain; Region: PEGA; pfam08308 448385020431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020432 AAA domain; Region: AAA_23; pfam13476 448385020433 Walker A/P-loop; other site 448385020434 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020435 AAA domain; Region: AAA_21; pfam13304 448385020436 ABC transporter signature motif; other site 448385020437 Walker B; other site 448385020438 D-loop; other site 448385020439 H-loop/switch region; other site 448385020440 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 448385020441 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 448385020442 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 448385020443 peptidase domain interface [polypeptide binding]; other site 448385020444 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 448385020445 active site 448385020446 catalytic triad [active] 448385020447 calcium binding site [ion binding]; other site 448385020448 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385020449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385020450 ATP binding site [chemical binding]; other site 448385020451 putative Mg++ binding site [ion binding]; other site 448385020452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385020453 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 448385020454 nucleotide binding region [chemical binding]; other site 448385020455 ATP-binding site [chemical binding]; other site 448385020456 phage shock protein A; Region: phageshock_pspA; TIGR02977 448385020457 pyruvate phosphate dikinase; Provisional; Region: PRK09279 448385020458 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385020459 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385020460 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 448385020461 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385020462 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 448385020463 Predicted ATPase [General function prediction only]; Region: COG4637 448385020464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020465 Walker A/P-loop; other site 448385020466 ATP binding site [chemical binding]; other site 448385020467 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 448385020468 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 448385020469 substrate binding site [chemical binding]; other site 448385020470 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 448385020471 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 448385020472 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385020473 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385020474 ligand binding site [chemical binding]; other site 448385020475 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385020476 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385020477 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385020478 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385020479 BolA-like protein; Region: BolA; pfam01722 448385020480 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 448385020481 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 448385020482 dimer interface [polypeptide binding]; other site 448385020483 active site 448385020484 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 448385020485 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 448385020486 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 448385020487 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385020488 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 448385020489 substrate binding site [chemical binding]; other site 448385020490 oxyanion hole (OAH) forming residues; other site 448385020491 trimer interface [polypeptide binding]; other site 448385020492 Double zinc ribbon; Region: DZR; pfam12773 448385020493 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385020494 protein binding site [polypeptide binding]; other site 448385020495 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 448385020496 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 448385020497 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 448385020498 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 448385020499 Walker A/P-loop; other site 448385020500 ATP binding site [chemical binding]; other site 448385020501 Q-loop/lid; other site 448385020502 ABC transporter signature motif; other site 448385020503 Walker B; other site 448385020504 D-loop; other site 448385020505 H-loop/switch region; other site 448385020506 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 448385020507 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 448385020508 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 448385020509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385020510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385020511 DNA binding residues [nucleotide binding] 448385020512 Putative zinc-finger; Region: zf-HC2; pfam13490 448385020513 glutathione synthetase; Provisional; Region: PRK05246 448385020514 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 448385020515 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 448385020516 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 448385020517 catalytic center binding site [active] 448385020518 ATP binding site [chemical binding]; other site 448385020519 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 448385020520 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 448385020521 active site 448385020522 catalytic site [active] 448385020523 substrate binding site [chemical binding]; other site 448385020524 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385020525 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385020526 Response regulator receiver domain; Region: Response_reg; pfam00072 448385020527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385020528 active site 448385020529 phosphorylation site [posttranslational modification] 448385020530 intermolecular recognition site; other site 448385020531 dimerization interface [polypeptide binding]; other site 448385020532 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 448385020533 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385020534 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385020535 putative active site [active] 448385020536 putative metal binding site [ion binding]; other site 448385020537 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 448385020538 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 448385020539 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385020540 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385020541 active site 448385020542 catalytic tetrad [active] 448385020543 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 448385020544 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 448385020545 heme-binding residues [chemical binding]; other site 448385020546 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 448385020547 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 448385020548 molybdopterin cofactor binding site; other site 448385020549 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 448385020550 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 448385020551 4Fe-4S binding domain; Region: Fer4; cl02805 448385020552 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 448385020553 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 448385020554 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 448385020555 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 448385020556 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 448385020557 Cu(I) binding site [ion binding]; other site 448385020558 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 448385020559 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 448385020560 Cytochrome c; Region: Cytochrom_C; cl11414 448385020561 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 448385020562 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 448385020563 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 448385020564 Subunit I/III interface [polypeptide binding]; other site 448385020565 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 448385020566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385020567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385020568 dimer interface [polypeptide binding]; other site 448385020569 phosphorylation site [posttranslational modification] 448385020570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385020571 ATP binding site [chemical binding]; other site 448385020572 G-X-G motif; other site 448385020573 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 448385020574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385020575 active site 448385020576 phosphorylation site [posttranslational modification] 448385020577 intermolecular recognition site; other site 448385020578 dimerization interface [polypeptide binding]; other site 448385020579 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385020580 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 448385020581 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 448385020582 homodimer interface [polypeptide binding]; other site 448385020583 substrate-cofactor binding pocket; other site 448385020584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385020585 catalytic residue [active] 448385020586 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 448385020587 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 448385020588 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 448385020589 Part of AAA domain; Region: AAA_19; pfam13245 448385020590 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 448385020591 Family description; Region: UvrD_C_2; pfam13538 448385020592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020593 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020594 active site 448385020595 ATP binding site [chemical binding]; other site 448385020596 substrate binding site [chemical binding]; other site 448385020597 activation loop (A-loop); other site 448385020598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020600 active site 448385020601 ATP binding site [chemical binding]; other site 448385020602 substrate binding site [chemical binding]; other site 448385020603 activation loop (A-loop); other site 448385020604 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 448385020605 CAAX protease self-immunity; Region: Abi; pfam02517 448385020606 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 448385020607 TM2 domain; Region: TM2; pfam05154 448385020608 TM2 domain; Region: TM2; pfam05154 448385020609 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 448385020610 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 448385020611 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385020612 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 448385020613 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385020614 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 448385020615 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385020616 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 448385020617 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385020618 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 448385020619 G1 box; other site 448385020620 GTP/Mg2+ binding site [chemical binding]; other site 448385020621 Switch I region; other site 448385020622 G2 box; other site 448385020623 G3 box; other site 448385020624 Switch II region; other site 448385020625 G4 box; other site 448385020626 G5 box; other site 448385020627 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 448385020628 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385020629 mbt repeat; Region: MBT; cl17705 448385020630 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 448385020631 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 448385020632 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385020633 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385020634 phosphopeptide binding site; other site 448385020635 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385020636 GAF domain; Region: GAF_3; pfam13492 448385020637 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385020638 cyclase homology domain; Region: CHD; cd07302 448385020639 nucleotidyl binding site; other site 448385020640 metal binding site [ion binding]; metal-binding site 448385020641 dimer interface [polypeptide binding]; other site 448385020642 glycerol kinase; Provisional; Region: glpK; PRK00047 448385020643 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 448385020644 N- and C-terminal domain interface [polypeptide binding]; other site 448385020645 active site 448385020646 MgATP binding site [chemical binding]; other site 448385020647 catalytic site [active] 448385020648 metal binding site [ion binding]; metal-binding site 448385020649 glycerol binding site [chemical binding]; other site 448385020650 homotetramer interface [polypeptide binding]; other site 448385020651 homodimer interface [polypeptide binding]; other site 448385020652 FBP binding site [chemical binding]; other site 448385020653 protein IIAGlc interface [polypeptide binding]; other site 448385020654 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 448385020655 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385020656 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 448385020657 YbbR-like protein; Region: YbbR; pfam07949 448385020658 Uncharacterized conserved protein [Function unknown]; Region: COG1624 448385020659 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 448385020660 dihydropteroate synthase; Region: DHPS; TIGR01496 448385020661 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 448385020662 substrate binding pocket [chemical binding]; other site 448385020663 dimer interface [polypeptide binding]; other site 448385020664 inhibitor binding site; inhibition site 448385020665 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 448385020666 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 448385020667 Zn2+ binding site [ion binding]; other site 448385020668 Mg2+ binding site [ion binding]; other site 448385020669 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385020670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385020671 active site 448385020672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385020673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020674 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020675 active site 448385020676 ATP binding site [chemical binding]; other site 448385020677 substrate binding site [chemical binding]; other site 448385020678 activation loop (A-loop); other site 448385020679 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385020680 Domain of unknown function (DUF362); Region: DUF362; pfam04015 448385020681 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 448385020682 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 448385020683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 448385020684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 448385020685 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 448385020686 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 448385020687 active site 448385020688 dimerization interface [polypeptide binding]; other site 448385020689 Bacterial Na+/H+ antiporter B (NhaB); Region: NhaB; cl17323 448385020690 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 448385020691 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 448385020692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385020693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385020694 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 448385020695 Fe-S cluster binding site [ion binding]; other site 448385020696 active site 448385020697 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 448385020698 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 448385020699 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385020700 AMP-binding enzyme; Region: AMP-binding; pfam00501 448385020701 acyl-activating enzyme (AAE) consensus motif; other site 448385020702 AMP binding site [chemical binding]; other site 448385020703 active site 448385020704 CoA binding site [chemical binding]; other site 448385020705 Tubby C 2; Region: Tub_2; cl02043 448385020706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385020707 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385020708 active site 448385020709 metal binding site [ion binding]; metal-binding site 448385020710 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 448385020711 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 448385020712 mce related protein; Region: MCE; pfam02470 448385020713 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 448385020714 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 448385020715 cell shape determining protein, MreB/Mrl family; Region: mreB; TIGR00904 448385020716 nucleotide binding site [chemical binding]; other site 448385020717 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385020718 SBD interface [polypeptide binding]; other site 448385020719 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 448385020720 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 448385020721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 448385020722 dimer interface [polypeptide binding]; other site 448385020723 active site 448385020724 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 448385020725 catalytic site [active] 448385020726 putative active site [active] 448385020727 putative substrate binding site [chemical binding]; other site 448385020728 dimer interface [polypeptide binding]; other site 448385020729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385020730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385020731 non-specific DNA binding site [nucleotide binding]; other site 448385020732 salt bridge; other site 448385020733 sequence-specific DNA binding site [nucleotide binding]; other site 448385020734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020735 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 448385020736 Walker A/P-loop; other site 448385020737 ATP binding site [chemical binding]; other site 448385020738 Q-loop/lid; other site 448385020739 ABC transporter signature motif; other site 448385020740 Walker B; other site 448385020741 D-loop; other site 448385020742 H-loop/switch region; other site 448385020743 arginine-tRNA ligase; Region: PLN02286 448385020744 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 448385020745 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 448385020746 active site 448385020747 HIGH motif; other site 448385020748 KMSK motif region; other site 448385020749 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 448385020750 tRNA binding surface [nucleotide binding]; other site 448385020751 anticodon binding site; other site 448385020752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385020753 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020754 active site 448385020755 ATP binding site [chemical binding]; other site 448385020756 substrate binding site [chemical binding]; other site 448385020757 activation loop (A-loop); other site 448385020758 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 448385020759 beta-galactosidase; Region: BGL; TIGR03356 448385020760 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 448385020761 metal-binding site [ion binding] 448385020762 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385020763 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 448385020764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 448385020765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 448385020766 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 448385020767 Kazal-type serine protease inhibitor domain; Region: Kazal_1; pfam00050 448385020768 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385020769 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385020770 putative active site [active] 448385020771 putative metal binding site [ion binding]; other site 448385020772 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 448385020773 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 448385020774 active site 448385020775 substrate binding site [chemical binding]; other site 448385020776 FMN binding site [chemical binding]; other site 448385020777 putative catalytic residues [active] 448385020778 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 448385020779 Nuclease-related domain; Region: NERD; pfam08378 448385020780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020781 active site 448385020782 ATP binding site [chemical binding]; other site 448385020783 substrate binding site [chemical binding]; other site 448385020784 activation loop (A-loop); other site 448385020785 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020786 active site 448385020787 ATP binding site [chemical binding]; other site 448385020788 substrate binding site [chemical binding]; other site 448385020789 activation loop (A-loop); other site 448385020790 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 448385020791 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385020792 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 448385020793 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385020794 Family description; Region: VCBS; pfam13517 448385020795 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385020796 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385020797 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 448385020798 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385020799 DNA binding residues [nucleotide binding] 448385020800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020801 AAA domain; Region: AAA_23; pfam13476 448385020802 Walker A/P-loop; other site 448385020803 ATP binding site [chemical binding]; other site 448385020804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385020805 Q-loop/lid; other site 448385020806 ABC transporter signature motif; other site 448385020807 Walker B; other site 448385020808 D-loop; other site 448385020809 H-loop/switch region; other site 448385020810 TIGR02646 family protein; Region: TIGR02646 448385020811 PglZ domain; Region: PglZ; pfam08665 448385020812 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 448385020813 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385020814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385020815 ATP binding site [chemical binding]; other site 448385020816 putative Mg++ binding site [ion binding]; other site 448385020817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385020818 nucleotide binding region [chemical binding]; other site 448385020819 ATP-binding site [chemical binding]; other site 448385020820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020821 active site 448385020822 ATP binding site [chemical binding]; other site 448385020823 substrate binding site [chemical binding]; other site 448385020824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020825 activation loop (A-loop); other site 448385020826 AAA ATPase domain; Region: AAA_16; pfam13191 448385020827 Predicted ATPase [General function prediction only]; Region: COG3899 448385020828 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385020829 GAF domain; Region: GAF; cl17456 448385020830 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385020831 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385020832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385020833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385020834 dimer interface [polypeptide binding]; other site 448385020835 phosphorylation site [posttranslational modification] 448385020836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385020837 ATP binding site [chemical binding]; other site 448385020838 Mg2+ binding site [ion binding]; other site 448385020839 G-X-G motif; other site 448385020840 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385020841 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385020842 PA14 domain; Region: PA14; cl08459 448385020843 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385020844 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385020845 active site 448385020846 metal binding site [ion binding]; metal-binding site 448385020847 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 448385020848 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 448385020849 active site 448385020850 catalytic residues [active] 448385020851 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 448385020852 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 448385020853 enolase; Provisional; Region: eno; PRK00077 448385020854 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 448385020855 dimer interface [polypeptide binding]; other site 448385020856 metal binding site [ion binding]; metal-binding site 448385020857 substrate binding pocket [chemical binding]; other site 448385020858 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 448385020859 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 448385020860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020862 active site 448385020863 ATP binding site [chemical binding]; other site 448385020864 substrate binding site [chemical binding]; other site 448385020865 activation loop (A-loop); other site 448385020866 AAA ATPase domain; Region: AAA_16; pfam13191 448385020867 Predicted ATPase [General function prediction only]; Region: COG3899 448385020868 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385020869 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385020870 PAS domain S-box; Region: sensory_box; TIGR00229 448385020871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385020872 putative active site [active] 448385020873 heme pocket [chemical binding]; other site 448385020874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 448385020875 HWE histidine kinase; Region: HWE_HK; pfam07536 448385020876 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 448385020877 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 448385020878 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 448385020879 putative dimer interface [polypeptide binding]; other site 448385020880 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385020881 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 448385020882 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385020883 Cytochrome c; Region: Cytochrom_C; pfam00034 448385020884 hypothetical protein; Provisional; Region: PRK05409 448385020885 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 448385020886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385020887 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385020888 non-specific DNA binding site [nucleotide binding]; other site 448385020889 salt bridge; other site 448385020890 sequence-specific DNA binding site [nucleotide binding]; other site 448385020891 Cupin domain; Region: Cupin_2; cl17218 448385020892 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385020893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385020894 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 448385020895 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 448385020896 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385020897 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385020898 active site 448385020899 metal binding site [ion binding]; metal-binding site 448385020900 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 448385020901 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 448385020902 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385020903 ATP binding site [chemical binding]; other site 448385020904 putative Mg++ binding site [ion binding]; other site 448385020905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385020906 nucleotide binding region [chemical binding]; other site 448385020907 ATP-binding site [chemical binding]; other site 448385020908 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 448385020909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385020910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385020911 active site 448385020912 ATP binding site [chemical binding]; other site 448385020913 substrate binding site [chemical binding]; other site 448385020914 activation loop (A-loop); other site 448385020915 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 448385020916 putative FMN binding site [chemical binding]; other site 448385020917 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 448385020918 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385020919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 448385020920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385020921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385020922 active site 448385020923 catalytic tetrad [active] 448385020924 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 448385020925 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; pfam09699 448385020926 TPR repeat; Region: TPR_11; pfam13414 448385020927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385020928 binding surface 448385020929 TPR motif; other site 448385020930 TPR repeat; Region: TPR_11; pfam13414 448385020931 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 448385020932 Sulfatase; Region: Sulfatase; pfam00884 448385020933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385020934 dimerization interface [polypeptide binding]; other site 448385020935 putative DNA binding site [nucleotide binding]; other site 448385020936 putative Zn2+ binding site [ion binding]; other site 448385020937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385020938 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 448385020939 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 448385020940 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 448385020941 substrate binding pocket [chemical binding]; other site 448385020942 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 448385020943 B12 binding site [chemical binding]; other site 448385020944 cobalt ligand [ion binding]; other site 448385020945 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 448385020946 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385020947 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385020948 putative C-terminal domain interface [polypeptide binding]; other site 448385020949 putative GSH binding site (G-site) [chemical binding]; other site 448385020950 putative dimer interface [polypeptide binding]; other site 448385020951 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 448385020952 dimer interface [polypeptide binding]; other site 448385020953 N-terminal domain interface [polypeptide binding]; other site 448385020954 putative substrate binding pocket (H-site) [chemical binding]; other site 448385020955 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 448385020956 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385020957 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385020958 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385020959 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385020960 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385020961 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385020962 BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure; Region: KU; cd00109 448385020963 trypsin interaction site; other site 448385020964 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385020965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385020966 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385020967 HEAT repeats; Region: HEAT_2; pfam13646 448385020968 non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276 448385020969 RNA/DNA hybrid binding site [nucleotide binding]; other site 448385020970 active site 448385020971 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 448385020972 active site 448385020973 metal binding site [ion binding]; metal-binding site 448385020974 Cytochrome c; Region: Cytochrom_C; pfam00034 448385020975 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 448385020976 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 448385020977 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385020978 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385020979 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 448385020980 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385020981 Walker A/P-loop; other site 448385020982 ATP binding site [chemical binding]; other site 448385020983 Q-loop/lid; other site 448385020984 ABC transporter signature motif; other site 448385020985 Walker B; other site 448385020986 D-loop; other site 448385020987 H-loop/switch region; other site 448385020988 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385020989 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 448385020990 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385020991 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385020992 TM-ABC transporter signature motif; other site 448385020993 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385020994 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 448385020995 TM-ABC transporter signature motif; other site 448385020996 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 448385020997 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 448385020998 ligand binding site [chemical binding]; other site 448385020999 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 448385021000 Cytochrome c; Region: Cytochrom_C; pfam00034 448385021001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021003 dimer interface [polypeptide binding]; other site 448385021004 phosphorylation site [posttranslational modification] 448385021005 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 448385021006 ATP binding site [chemical binding]; other site 448385021007 Mg2+ binding site [ion binding]; other site 448385021008 G-X-G motif; other site 448385021009 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021011 active site 448385021012 phosphorylation site [posttranslational modification] 448385021013 intermolecular recognition site; other site 448385021014 dimerization interface [polypeptide binding]; other site 448385021015 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 448385021016 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385021017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385021018 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 448385021019 putative effector binding pocket; other site 448385021020 putative dimerization interface [polypeptide binding]; other site 448385021021 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385021022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385021023 NAD(P) binding site [chemical binding]; other site 448385021024 active site 448385021025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 448385021026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021027 S-adenosylmethionine binding site [chemical binding]; other site 448385021028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385021029 putative DNA binding site [nucleotide binding]; other site 448385021030 putative Zn2+ binding site [ion binding]; other site 448385021031 Beta-lactamase; Region: Beta-lactamase; pfam00144 448385021032 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 448385021033 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 448385021034 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385021035 dimerization interface [polypeptide binding]; other site 448385021036 ligand binding site [chemical binding]; other site 448385021037 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385021038 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021040 active site 448385021041 phosphorylation site [posttranslational modification] 448385021042 intermolecular recognition site; other site 448385021043 dimerization interface [polypeptide binding]; other site 448385021044 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 448385021045 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 448385021046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021047 dimer interface [polypeptide binding]; other site 448385021048 phosphorylation site [posttranslational modification] 448385021049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021050 ATP binding site [chemical binding]; other site 448385021051 Mg2+ binding site [ion binding]; other site 448385021052 G-X-G motif; other site 448385021053 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385021054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021055 active site 448385021056 phosphorylation site [posttranslational modification] 448385021057 intermolecular recognition site; other site 448385021058 dimerization interface [polypeptide binding]; other site 448385021059 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021061 active site 448385021062 phosphorylation site [posttranslational modification] 448385021063 intermolecular recognition site; other site 448385021064 dimerization interface [polypeptide binding]; other site 448385021065 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 448385021066 putative binding surface; other site 448385021067 active site 448385021068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 448385021069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385021070 dimer interface [polypeptide binding]; other site 448385021071 conserved gate region; other site 448385021072 putative PBP binding loops; other site 448385021073 ABC-ATPase subunit interface; other site 448385021074 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 448385021075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385021076 dimer interface [polypeptide binding]; other site 448385021077 conserved gate region; other site 448385021078 putative PBP binding loops; other site 448385021079 ABC-ATPase subunit interface; other site 448385021080 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 448385021081 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 448385021082 Walker A/P-loop; other site 448385021083 ATP binding site [chemical binding]; other site 448385021084 Q-loop/lid; other site 448385021085 ABC transporter signature motif; other site 448385021086 Walker B; other site 448385021087 D-loop; other site 448385021088 H-loop/switch region; other site 448385021089 TOBE domain; Region: TOBE; pfam03459 448385021090 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 448385021091 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 448385021092 active site 448385021093 catalytic site [active] 448385021094 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 448385021095 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385021096 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385021097 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385021098 structural tetrad; other site 448385021099 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385021100 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385021101 structural tetrad; other site 448385021102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021104 active site 448385021105 ATP binding site [chemical binding]; other site 448385021106 substrate binding site [chemical binding]; other site 448385021107 activation loop (A-loop); other site 448385021108 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 448385021109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385021110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 448385021111 putative substrate translocation pore; other site 448385021112 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 448385021113 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385021114 active site 448385021115 DNA binding site [nucleotide binding] 448385021116 Int/Topo IB signature motif; other site 448385021117 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 448385021118 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 448385021119 Sulfatase; Region: Sulfatase; pfam00884 448385021120 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385021121 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385021122 MarR family; Region: MarR_2; cl17246 448385021123 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 448385021124 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385021125 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385021126 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 448385021127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385021128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385021129 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385021130 substrate binding pocket [chemical binding]; other site 448385021131 dimerization interface [polypeptide binding]; other site 448385021132 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 448385021133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021134 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021135 dimerization interface [polypeptide binding]; other site 448385021136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021137 dimer interface [polypeptide binding]; other site 448385021138 phosphorylation site [posttranslational modification] 448385021139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021140 ATP binding site [chemical binding]; other site 448385021141 Mg2+ binding site [ion binding]; other site 448385021142 G-X-G motif; other site 448385021143 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385021144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021145 active site 448385021146 phosphorylation site [posttranslational modification] 448385021147 intermolecular recognition site; other site 448385021148 dimerization interface [polypeptide binding]; other site 448385021149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385021150 Walker A motif; other site 448385021151 ATP binding site [chemical binding]; other site 448385021152 Walker B motif; other site 448385021153 arginine finger; other site 448385021154 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385021155 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385021156 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385021157 ligand binding site [chemical binding]; other site 448385021158 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 448385021159 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 448385021160 metal ion-dependent adhesion site (MIDAS); other site 448385021161 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021163 active site 448385021164 phosphorylation site [posttranslational modification] 448385021165 intermolecular recognition site; other site 448385021166 dimerization interface [polypeptide binding]; other site 448385021167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385021168 PAS domain; Region: PAS_9; pfam13426 448385021169 putative active site [active] 448385021170 heme pocket [chemical binding]; other site 448385021171 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385021172 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385021173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021174 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021175 dimer interface [polypeptide binding]; other site 448385021176 phosphorylation site [posttranslational modification] 448385021177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021178 ATP binding site [chemical binding]; other site 448385021179 Mg2+ binding site [ion binding]; other site 448385021180 G-X-G motif; other site 448385021181 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 448385021182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021183 dimerization interface [polypeptide binding]; other site 448385021184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021185 dimerization interface [polypeptide binding]; other site 448385021186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021187 dimerization interface [polypeptide binding]; other site 448385021188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021189 dimerization interface [polypeptide binding]; other site 448385021190 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 448385021191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021192 dimerization interface [polypeptide binding]; other site 448385021193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021194 dimerization interface [polypeptide binding]; other site 448385021195 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021196 dimerization interface [polypeptide binding]; other site 448385021197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021198 dimerization interface [polypeptide binding]; other site 448385021199 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 448385021200 GAF domain; Region: GAF_2; pfam13185 448385021201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021203 dimer interface [polypeptide binding]; other site 448385021204 phosphorylation site [posttranslational modification] 448385021205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021206 ATP binding site [chemical binding]; other site 448385021207 Mg2+ binding site [ion binding]; other site 448385021208 G-X-G motif; other site 448385021209 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021211 active site 448385021212 phosphorylation site [posttranslational modification] 448385021213 intermolecular recognition site; other site 448385021214 dimerization interface [polypeptide binding]; other site 448385021215 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021217 active site 448385021218 phosphorylation site [posttranslational modification] 448385021219 intermolecular recognition site; other site 448385021220 dimerization interface [polypeptide binding]; other site 448385021221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021222 dimerization interface [polypeptide binding]; other site 448385021223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021225 dimer interface [polypeptide binding]; other site 448385021226 phosphorylation site [posttranslational modification] 448385021227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021228 ATP binding site [chemical binding]; other site 448385021229 Mg2+ binding site [ion binding]; other site 448385021230 G-X-G motif; other site 448385021231 Predicted transcriptional regulators [Transcription]; Region: COG1733 448385021232 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 448385021233 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 448385021234 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 448385021235 FMN binding site [chemical binding]; other site 448385021236 active site 448385021237 substrate binding site [chemical binding]; other site 448385021238 catalytic residue [active] 448385021239 HEAT repeats; Region: HEAT_2; pfam13646 448385021240 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021242 active site 448385021243 phosphorylation site [posttranslational modification] 448385021244 intermolecular recognition site; other site 448385021245 dimerization interface [polypeptide binding]; other site 448385021246 hypothetical protein; Region: PHA01623 448385021247 ParA-like protein; Provisional; Region: PHA02518 448385021248 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 448385021249 P-loop; other site 448385021250 Magnesium ion binding site [ion binding]; other site 448385021251 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 448385021252 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 448385021253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 448385021254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385021255 Coenzyme A binding pocket [chemical binding]; other site 448385021256 PAS domain; Region: PAS_9; pfam13426 448385021257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385021258 putative active site [active] 448385021259 heme pocket [chemical binding]; other site 448385021260 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385021261 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 448385021262 FAD binding domain; Region: FAD_binding_4; pfam01565 448385021263 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 448385021264 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385021265 active site 448385021266 substrate binding sites [chemical binding]; other site 448385021267 FG-GAP repeat; Region: FG-GAP; pfam01839 448385021268 Family description; Region: VCBS; pfam13517 448385021269 Family description; Region: VCBS; pfam13517 448385021270 Family description; Region: VCBS; pfam13517 448385021271 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385021272 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385021273 ZU5 domain; Region: ZU5; cl02517 448385021274 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385021275 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 448385021276 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385021277 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385021278 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 448385021279 Pretoxin HINT domain; Region: PT-HINT; pfam07591 448385021280 thioester formation/cholesterol transfer; other site 448385021281 protein-splicing catalytic site; other site 448385021282 SEC-C motif; Region: SEC-C; pfam02810 448385021283 Chorismate mutase type II; Region: CM_2; pfam01817 448385021284 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 448385021285 Prephenate dehydratase; Region: PDT; pfam00800 448385021286 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 448385021287 putative L-Phe binding site [chemical binding]; other site 448385021288 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385021289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385021290 DNA binding residues [nucleotide binding] 448385021291 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 448385021292 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385021293 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 448385021294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 448385021295 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385021296 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 448385021297 CotH protein; Region: CotH; pfam08757 448385021298 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385021299 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385021300 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385021301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021302 S-adenosylmethionine binding site [chemical binding]; other site 448385021303 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 448385021304 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 448385021305 Ligand binding site; other site 448385021306 Putative Catalytic site; other site 448385021307 DXD motif; other site 448385021308 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 448385021309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385021310 acyl-activating enzyme (AAE) consensus motif; other site 448385021311 active site 448385021312 AMP binding site [chemical binding]; other site 448385021313 CoA binding site [chemical binding]; other site 448385021314 Uncharacterized conserved protein [Function unknown]; Region: COG2006 448385021315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385021316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385021317 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385021318 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385021319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385021320 putative substrate translocation pore; other site 448385021321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385021322 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 448385021323 active site 448385021324 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 448385021325 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 448385021326 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385021327 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 448385021328 active site 448385021329 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385021330 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021331 active site 448385021332 ATP binding site [chemical binding]; other site 448385021333 substrate binding site [chemical binding]; other site 448385021334 activation loop (A-loop); other site 448385021335 AAA ATPase domain; Region: AAA_16; pfam13191 448385021336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385021337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385021338 non-specific DNA binding site [nucleotide binding]; other site 448385021339 salt bridge; other site 448385021340 sequence-specific DNA binding site [nucleotide binding]; other site 448385021341 Domain of unknown function (DUF4423); Region: DUF4423; pfam14394 448385021342 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 448385021343 four helix bundle protein; Region: TIGR02436 448385021344 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 448385021345 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385021346 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385021347 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385021348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021349 active site 448385021350 phosphorylation site [posttranslational modification] 448385021351 intermolecular recognition site; other site 448385021352 dimerization interface [polypeptide binding]; other site 448385021353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385021354 Walker A motif; other site 448385021355 ATP binding site [chemical binding]; other site 448385021356 Walker B motif; other site 448385021357 arginine finger; other site 448385021358 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 448385021359 CoenzymeA binding site [chemical binding]; other site 448385021360 subunit interaction site [polypeptide binding]; other site 448385021361 PHB binding site; other site 448385021362 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385021363 active site 2 [active] 448385021364 active site 1 [active] 448385021365 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 448385021366 HhH-GPD superfamily base excision DNA repair protein; Region: HhH-GPD; pfam00730 448385021367 helix-hairpin-helix signature motif; other site 448385021368 Uncharacterized conserved protein [Function unknown]; Region: COG3189 448385021369 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 448385021370 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385021371 Cytochrome P450; Region: p450; cl12078 448385021372 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385021373 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 448385021374 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 448385021375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385021376 Walker A/P-loop; other site 448385021377 ATP binding site [chemical binding]; other site 448385021378 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 448385021379 D5 N terminal like; Region: D5_N; cl07360 448385021380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021382 dimer interface [polypeptide binding]; other site 448385021383 phosphorylation site [posttranslational modification] 448385021384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021385 ATP binding site [chemical binding]; other site 448385021386 G-X-G motif; other site 448385021387 Protein of unknown function, DUF393; Region: DUF393; cl01136 448385021388 hypothetical protein; Provisional; Region: PRK06184 448385021389 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385021390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 448385021391 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385021392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385021393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385021394 RHS Repeat; Region: RHS_repeat; pfam05593 448385021395 RHS Repeat; Region: RHS_repeat; cl11982 448385021396 RHS Repeat; Region: RHS_repeat; pfam05593 448385021397 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385021398 RHS Repeat; Region: RHS_repeat; pfam05593 448385021399 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385021400 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385021401 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 448385021402 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 448385021403 active site 448385021404 HIGH motif; other site 448385021405 KMSKS motif; other site 448385021406 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 448385021407 anticodon binding site; other site 448385021408 tRNA binding surface [nucleotide binding]; other site 448385021409 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 448385021410 dimer interface [polypeptide binding]; other site 448385021411 putative tRNA-binding site [nucleotide binding]; other site 448385021412 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 448385021413 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 448385021414 dimerization interface [polypeptide binding]; other site 448385021415 DPS ferroxidase diiron center [ion binding]; other site 448385021416 ion pore; other site 448385021417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385021418 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 448385021419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385021420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385021421 DNA binding residues [nucleotide binding] 448385021422 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 448385021423 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 448385021424 active site 448385021425 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 448385021426 protein binding site [polypeptide binding]; other site 448385021427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385021428 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 448385021429 16S rRNA methyltransferase B; Provisional; Region: PRK14902 448385021430 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 448385021431 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 448385021432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021434 active site 448385021435 ATP binding site [chemical binding]; other site 448385021436 substrate binding site [chemical binding]; other site 448385021437 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385021438 substrate binding site [chemical binding]; other site 448385021439 activation loop (A-loop); other site 448385021440 activation loop (A-loop); other site 448385021441 PEGA domain; Region: PEGA; pfam08308 448385021442 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 448385021443 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385021444 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385021445 DNA binding residues [nucleotide binding] 448385021446 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385021447 active site 448385021448 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385021449 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 448385021450 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385021451 protein binding site [polypeptide binding]; other site 448385021452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385021453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385021454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385021455 DNA binding residues [nucleotide binding] 448385021456 FecR protein; Region: FecR; pfam04773 448385021457 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 448385021458 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385021459 cyclase homology domain; Region: CHD; cd07302 448385021460 dimer interface [polypeptide binding]; other site 448385021461 AAA ATPase domain; Region: AAA_16; pfam13191 448385021462 AAA ATPase domain; Region: AAA_16; pfam13191 448385021463 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 448385021464 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 448385021465 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 448385021466 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 448385021467 active site 448385021468 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 448385021469 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 448385021470 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 448385021471 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021473 active site 448385021474 ATP binding site [chemical binding]; other site 448385021475 substrate binding site [chemical binding]; other site 448385021476 activation loop (A-loop); other site 448385021477 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 448385021478 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 448385021479 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 448385021480 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385021481 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 448385021482 AAA domain; Region: AAA_30; pfam13604 448385021483 Family description; Region: UvrD_C_2; pfam13538 448385021484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385021485 binding surface 448385021486 TPR motif; other site 448385021487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385021488 binding surface 448385021489 TPR motif; other site 448385021490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385021491 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 448385021492 active site 448385021493 motif I; other site 448385021494 motif II; other site 448385021495 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385021496 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 448385021497 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 448385021498 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 448385021499 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 448385021500 Clp amino terminal domain; Region: Clp_N; pfam02861 448385021501 Clp amino terminal domain; Region: Clp_N; pfam02861 448385021502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385021503 Walker A motif; other site 448385021504 ATP binding site [chemical binding]; other site 448385021505 Walker B motif; other site 448385021506 arginine finger; other site 448385021507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385021508 Walker A motif; other site 448385021509 ATP binding site [chemical binding]; other site 448385021510 Walker B motif; other site 448385021511 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385021512 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 448385021513 GSH binding site [chemical binding]; other site 448385021514 catalytic residues [active] 448385021515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021517 active site 448385021518 ATP binding site [chemical binding]; other site 448385021519 substrate binding site [chemical binding]; other site 448385021520 activation loop (A-loop); other site 448385021521 TPR repeat; Region: TPR_11; pfam13414 448385021522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385021523 TPR motif; other site 448385021524 PEGA domain; Region: PEGA; pfam08308 448385021525 acetyl-CoA synthetase; Provisional; Region: PRK00174 448385021526 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 448385021527 active site 448385021528 CoA binding site [chemical binding]; other site 448385021529 acyl-activating enzyme (AAE) consensus motif; other site 448385021530 AMP binding site [chemical binding]; other site 448385021531 acetate binding site [chemical binding]; other site 448385021532 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021533 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021534 active site 448385021535 ATP binding site [chemical binding]; other site 448385021536 substrate binding site [chemical binding]; other site 448385021537 activation loop (A-loop); other site 448385021538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385021539 dimerization interface [polypeptide binding]; other site 448385021540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021541 dimer interface [polypeptide binding]; other site 448385021542 phosphorylation site [posttranslational modification] 448385021543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021544 ATP binding site [chemical binding]; other site 448385021545 G-X-G motif; other site 448385021546 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 448385021547 Cysteine-rich domain; Region: CCG; pfam02754 448385021548 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385021549 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385021550 GAF domain; Region: GAF; pfam01590 448385021551 GAF domain; Region: GAF_2; pfam13185 448385021552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021554 dimer interface [polypeptide binding]; other site 448385021555 phosphorylation site [posttranslational modification] 448385021556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021557 ATP binding site [chemical binding]; other site 448385021558 Mg2+ binding site [ion binding]; other site 448385021559 G-X-G motif; other site 448385021560 transcription termination factor Rho; Provisional; Region: rho; PRK09376 448385021561 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 448385021562 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 448385021563 RNA binding site [nucleotide binding]; other site 448385021564 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 448385021565 multimer interface [polypeptide binding]; other site 448385021566 Walker A motif; other site 448385021567 ATP binding site [chemical binding]; other site 448385021568 Walker B motif; other site 448385021569 Acylphosphatase; Region: Acylphosphatase; pfam00708 448385021570 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 448385021571 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 448385021572 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 448385021573 alphaNTD homodimer interface [polypeptide binding]; other site 448385021574 alphaNTD - beta interaction site [polypeptide binding]; other site 448385021575 alphaNTD - beta' interaction site [polypeptide binding]; other site 448385021576 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 448385021577 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 448385021578 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 448385021579 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385021580 RNA binding surface [nucleotide binding]; other site 448385021581 30S ribosomal protein S11; Validated; Region: PRK05309 448385021582 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 448385021583 30S ribosomal protein S13; Region: bact_S13; TIGR03631 448385021584 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 448385021585 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 448385021586 rRNA binding site [nucleotide binding]; other site 448385021587 predicted 30S ribosome binding site; other site 448385021588 adenylate kinase; Reviewed; Region: adk; PRK00279 448385021589 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 448385021590 AMP-binding site [chemical binding]; other site 448385021591 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 448385021592 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 448385021593 SecY translocase; Region: SecY; pfam00344 448385021594 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 448385021595 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 448385021596 23S rRNA binding site [nucleotide binding]; other site 448385021597 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 448385021598 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 448385021599 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 448385021600 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 448385021601 23S rRNA interface [nucleotide binding]; other site 448385021602 L21e interface [polypeptide binding]; other site 448385021603 5S rRNA interface [nucleotide binding]; other site 448385021604 L27 interface [polypeptide binding]; other site 448385021605 L5 interface [polypeptide binding]; other site 448385021606 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 448385021607 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 448385021608 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 448385021609 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 448385021610 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 448385021611 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 448385021612 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 448385021613 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 448385021614 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 448385021615 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 448385021616 RNA binding site [nucleotide binding]; other site 448385021617 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 448385021618 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 448385021619 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 448385021620 L23 interface [polypeptide binding]; other site 448385021621 signal recognition particle (SRP54) interaction site; other site 448385021622 trigger factor interaction site; other site 448385021623 23S rRNA interface [nucleotide binding]; other site 448385021624 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 448385021625 23S rRNA interface [nucleotide binding]; other site 448385021626 5S rRNA interface [nucleotide binding]; other site 448385021627 putative antibiotic binding site [chemical binding]; other site 448385021628 L25 interface [polypeptide binding]; other site 448385021629 L27 interface [polypeptide binding]; other site 448385021630 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 448385021631 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 448385021632 G-X-X-G motif; other site 448385021633 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 448385021634 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 448385021635 putative translocon binding site; other site 448385021636 protein-rRNA interface [nucleotide binding]; other site 448385021637 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385021638 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021639 S-adenosylmethionine binding site [chemical binding]; other site 448385021640 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 448385021641 PhoH-like protein; Region: PhoH; pfam02562 448385021642 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 448385021643 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385021644 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 448385021645 Surface antigen; Region: Bac_surface_Ag; pfam01103 448385021646 PilZ domain; Region: PilZ; cl01260 448385021647 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 448385021648 active site 448385021649 cosubstrate binding site; other site 448385021650 substrate binding site [chemical binding]; other site 448385021651 catalytic site [active] 448385021652 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 448385021653 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 448385021654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385021655 Walker A/P-loop; other site 448385021656 ATP binding site [chemical binding]; other site 448385021657 Q-loop/lid; other site 448385021658 ABC transporter signature motif; other site 448385021659 Walker B; other site 448385021660 D-loop; other site 448385021661 H-loop/switch region; other site 448385021662 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 448385021663 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 448385021664 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385021665 ribonuclease PH; Reviewed; Region: rph; PRK00173 448385021666 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 448385021667 oligomer interface [polypeptide binding]; other site 448385021668 RNA binding site [nucleotide binding]; other site 448385021669 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 448385021670 active site 448385021671 dimerization interface [polypeptide binding]; other site 448385021672 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 448385021673 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 448385021674 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 448385021675 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 448385021676 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385021677 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385021678 phosphopeptide binding site; other site 448385021679 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 448385021680 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 448385021681 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 448385021682 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 448385021683 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 448385021684 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 448385021685 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 448385021686 active site 448385021687 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 448385021688 protein binding site [polypeptide binding]; other site 448385021689 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 448385021690 putative substrate binding region [chemical binding]; other site 448385021691 Right handed beta helix region; Region: Beta_helix; pfam13229 448385021692 Right handed beta helix region; Region: Beta_helix; pfam13229 448385021693 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385021694 M28 Zn-Peptidases; Region: M28_like_1; cd05640 448385021695 Peptidase family M28; Region: Peptidase_M28; pfam04389 448385021696 metal binding site [ion binding]; metal-binding site 448385021697 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 448385021698 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 448385021699 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 448385021700 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 448385021701 putative acyl-acceptor binding pocket; other site 448385021702 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 448385021703 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 448385021704 active site 448385021705 methionine sulfoxide reductase B; Provisional; Region: PRK00222 448385021706 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 448385021707 methionine sulfoxide reductase A; Provisional; Region: PRK14054 448385021708 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 448385021709 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385021710 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385021711 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 448385021712 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 448385021713 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 448385021714 TPP-binding site [chemical binding]; other site 448385021715 tetramer interface [polypeptide binding]; other site 448385021716 heterodimer interface [polypeptide binding]; other site 448385021717 phosphorylation loop region [posttranslational modification] 448385021718 HEAT repeats; Region: HEAT_2; pfam13646 448385021719 4Fe-4S binding domain; Region: Fer4; cl02805 448385021720 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 448385021721 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021722 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021723 active site 448385021724 ATP binding site [chemical binding]; other site 448385021725 substrate binding site [chemical binding]; other site 448385021726 activation loop (A-loop); other site 448385021727 urocanate hydratase; Provisional; Region: PRK05414 448385021728 N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme; Region: TFIIS_I; cl00146 448385021729 endonuclease IV; Provisional; Region: PRK01060 448385021730 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 448385021731 AP (apurinic/apyrimidinic) site pocket; other site 448385021732 DNA interaction; other site 448385021733 Metal-binding active site; metal-binding site 448385021734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385021735 NAD(P) binding site [chemical binding]; other site 448385021736 active site 448385021737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385021738 active site 448385021739 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 448385021740 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 448385021741 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 448385021742 acyl-activating enzyme (AAE) consensus motif; other site 448385021743 putative AMP binding site [chemical binding]; other site 448385021744 putative active site [active] 448385021745 putative CoA binding site [chemical binding]; other site 448385021746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 448385021747 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 448385021748 putative acyl-acceptor binding pocket; other site 448385021749 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 448385021750 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 448385021751 putative NADP binding site [chemical binding]; other site 448385021752 putative substrate binding site [chemical binding]; other site 448385021753 active site 448385021754 FOG: CBS domain [General function prediction only]; Region: COG0517 448385021755 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 448385021756 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 448385021757 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 448385021758 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385021759 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385021760 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021761 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021762 active site 448385021763 ATP binding site [chemical binding]; other site 448385021764 substrate binding site [chemical binding]; other site 448385021765 activation loop (A-loop); other site 448385021766 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385021767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021768 S-adenosylmethionine binding site [chemical binding]; other site 448385021769 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 448385021770 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 448385021771 Ligand binding site; other site 448385021772 Putative Catalytic site; other site 448385021773 DXD motif; other site 448385021774 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 448385021775 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 448385021776 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 448385021777 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 448385021778 4Fe-4S binding domain; Region: Fer4; cl02805 448385021779 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 448385021780 dihydrodipicolinate synthase; Region: dapA; TIGR00674 448385021781 dimer interface [polypeptide binding]; other site 448385021782 active site 448385021783 catalytic residue [active] 448385021784 dihydrodipicolinate reductase; Provisional; Region: PRK00048 448385021785 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 448385021786 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 448385021787 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 448385021788 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 448385021789 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385021790 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385021791 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385021792 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385021793 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385021794 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 448385021795 heat shock protein HtpX; Provisional; Region: PRK03982 448385021796 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 448385021797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 448385021799 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 448385021800 Peptidase family M50; Region: Peptidase_M50; pfam02163 448385021801 active site 448385021802 putative substrate binding region [chemical binding]; other site 448385021803 FOG: CBS domain [General function prediction only]; Region: COG0517 448385021804 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 448385021805 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 448385021806 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 448385021807 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385021808 active site 448385021809 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 448385021810 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 448385021811 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 448385021812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021813 active site 448385021814 phosphorylation site [posttranslational modification] 448385021815 intermolecular recognition site; other site 448385021816 dimerization interface [polypeptide binding]; other site 448385021817 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385021818 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385021819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021820 dimer interface [polypeptide binding]; other site 448385021821 phosphorylation site [posttranslational modification] 448385021822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021823 ATP binding site [chemical binding]; other site 448385021824 Mg2+ binding site [ion binding]; other site 448385021825 G-X-G motif; other site 448385021826 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 448385021827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021828 S-adenosylmethionine binding site [chemical binding]; other site 448385021829 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 448385021830 active site 448385021831 substrate binding site [chemical binding]; other site 448385021832 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 448385021833 metal binding site [ion binding]; metal-binding site 448385021834 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 448385021835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385021836 S-adenosylmethionine binding site [chemical binding]; other site 448385021837 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 448385021838 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 448385021839 dimerization interface 3.5A [polypeptide binding]; other site 448385021840 active site 448385021841 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 448385021842 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 448385021843 HD domain; Region: HD_4; pfam13328 448385021844 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 448385021845 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 448385021846 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385021847 ligand binding site [chemical binding]; other site 448385021848 conserved repeat domain; Region: B_ant_repeat; TIGR01451 448385021849 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 448385021850 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 448385021851 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 448385021852 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 448385021853 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385021854 Response regulator receiver domain; Region: Response_reg; pfam00072 448385021855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021856 active site 448385021857 phosphorylation site [posttranslational modification] 448385021858 intermolecular recognition site; other site 448385021859 dimerization interface [polypeptide binding]; other site 448385021860 Methyltransferase domain; Region: Methyltransf_26; pfam13659 448385021861 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 448385021862 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 448385021863 Thioredoxin; Region: Thioredoxin_4; cl17273 448385021864 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 448385021865 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385021866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385021867 LysR substrate binding domain; Region: LysR_substrate; pfam03466 448385021868 dimerization interface [polypeptide binding]; other site 448385021869 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 448385021870 phosphodiesterase YaeI; Provisional; Region: PRK11340 448385021871 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 448385021872 putative active site [active] 448385021873 putative metal binding site [ion binding]; other site 448385021874 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 448385021875 nucleotide binding site [chemical binding]; other site 448385021876 putative NEF/HSP70 interaction site [polypeptide binding]; other site 448385021877 SBD interface [polypeptide binding]; other site 448385021878 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385021879 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385021880 active site 448385021881 ATP binding site [chemical binding]; other site 448385021882 substrate binding site [chemical binding]; other site 448385021883 activation loop (A-loop); other site 448385021884 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 448385021885 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385021886 active site 448385021887 HIGH motif; other site 448385021888 nucleotide binding site [chemical binding]; other site 448385021889 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385021890 active site 448385021891 KMSKS motif; other site 448385021892 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 448385021893 anticodon binding site; other site 448385021894 tRNA binding surface [nucleotide binding]; other site 448385021895 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 448385021896 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 448385021897 metal-binding site [ion binding] 448385021898 FeoA domain; Region: FeoA; pfam04023 448385021899 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 448385021900 G1 box; other site 448385021901 GTP/Mg2+ binding site [chemical binding]; other site 448385021902 G2 box; other site 448385021903 Switch I region; other site 448385021904 G3 box; other site 448385021905 Switch II region; other site 448385021906 G4 box; other site 448385021907 G5 box; other site 448385021908 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 448385021909 Nucleoside recognition; Region: Gate; pfam07670 448385021910 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 448385021911 Nucleoside recognition; Region: Gate; pfam07670 448385021912 GAF domain; Region: GAF; cl17456 448385021913 PAS domain; Region: PAS_9; pfam13426 448385021914 PAS domain S-box; Region: sensory_box; TIGR00229 448385021915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385021916 putative active site [active] 448385021917 heme pocket [chemical binding]; other site 448385021918 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 448385021919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021920 dimer interface [polypeptide binding]; other site 448385021921 phosphorylation site [posttranslational modification] 448385021922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021923 ATP binding site [chemical binding]; other site 448385021924 Mg2+ binding site [ion binding]; other site 448385021925 G-X-G motif; other site 448385021926 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 448385021927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385021928 putative substrate translocation pore; other site 448385021929 Cation efflux family; Region: Cation_efflux; pfam01545 448385021930 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 448385021931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385021932 NAD(P) binding site [chemical binding]; other site 448385021933 active site 448385021934 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 448385021935 dimerization interface [polypeptide binding]; other site 448385021936 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 448385021937 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 448385021938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385021939 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385021940 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 448385021941 Domain of unknown function (DUF305); Region: DUF305; pfam03713 448385021942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385021943 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385021944 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385021945 Multicopper oxidase; Region: Cu-oxidase; pfam00394 448385021946 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385021947 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 448385021948 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 448385021949 Multicopper oxidase; Region: Cu-oxidase; pfam00394 448385021950 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385021951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385021952 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 448385021953 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 448385021954 YHS domain; Region: YHS; pfam04945 448385021955 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 448385021956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 448385021957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385021958 motif II; other site 448385021959 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385021960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021961 active site 448385021962 phosphorylation site [posttranslational modification] 448385021963 intermolecular recognition site; other site 448385021964 dimerization interface [polypeptide binding]; other site 448385021965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385021966 Walker A motif; other site 448385021967 ATP binding site [chemical binding]; other site 448385021968 Walker B motif; other site 448385021969 arginine finger; other site 448385021970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385021971 dimer interface [polypeptide binding]; other site 448385021972 phosphorylation site [posttranslational modification] 448385021973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385021974 ATP binding site [chemical binding]; other site 448385021975 Mg2+ binding site [ion binding]; other site 448385021976 G-X-G motif; other site 448385021977 Outer membrane efflux protein; Region: OEP; pfam02321 448385021978 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385021979 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 448385021980 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 448385021981 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 448385021982 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 448385021983 putative catalytic site [active] 448385021984 putative phosphate binding site [ion binding]; other site 448385021985 active site 448385021986 metal binding site A [ion binding]; metal-binding site 448385021987 DNA binding site [nucleotide binding] 448385021988 putative AP binding site [nucleotide binding]; other site 448385021989 putative metal binding site B [ion binding]; other site 448385021990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 448385021991 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385021992 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385021993 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385021994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 448385021995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385021996 active site 448385021997 phosphorylation site [posttranslational modification] 448385021998 intermolecular recognition site; other site 448385021999 dimerization interface [polypeptide binding]; other site 448385022000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 448385022001 DNA binding residues [nucleotide binding] 448385022002 dimerization interface [polypeptide binding]; other site 448385022003 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022005 active site 448385022006 phosphorylation site [posttranslational modification] 448385022007 intermolecular recognition site; other site 448385022008 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 448385022009 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 448385022010 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 448385022011 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 448385022012 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385022013 Ligand Binding Site [chemical binding]; other site 448385022014 AAA domain; Region: AAA_32; pfam13654 448385022015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 448385022016 Walker A motif; other site 448385022017 ATP binding site [chemical binding]; other site 448385022018 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 448385022019 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022021 active site 448385022022 phosphorylation site [posttranslational modification] 448385022023 intermolecular recognition site; other site 448385022024 PAS domain S-box; Region: sensory_box; TIGR00229 448385022025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385022026 putative active site [active] 448385022027 heme pocket [chemical binding]; other site 448385022028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385022029 GAF domain; Region: GAF; pfam01590 448385022030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385022031 dimer interface [polypeptide binding]; other site 448385022032 phosphorylation site [posttranslational modification] 448385022033 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 448385022034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385022035 ATP binding site [chemical binding]; other site 448385022036 Mg2+ binding site [ion binding]; other site 448385022037 G-X-G motif; other site 448385022038 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 448385022039 hypothetical protein; Provisional; Region: PRK05858 448385022040 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 448385022041 PYR/PP interface [polypeptide binding]; other site 448385022042 dimer interface [polypeptide binding]; other site 448385022043 TPP binding site [chemical binding]; other site 448385022044 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 448385022045 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 448385022046 TPP-binding site; other site 448385022047 dimer interface [polypeptide binding]; other site 448385022048 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385022049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385022050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385022051 catalytic residue [active] 448385022052 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385022053 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385022054 metal ion-dependent adhesion site (MIDAS); other site 448385022055 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 448385022056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385022057 Ligand Binding Site [chemical binding]; other site 448385022058 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 448385022059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385022060 putative active site [active] 448385022061 heme pocket [chemical binding]; other site 448385022062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385022063 dimer interface [polypeptide binding]; other site 448385022064 phosphorylation site [posttranslational modification] 448385022065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385022066 ATP binding site [chemical binding]; other site 448385022067 Mg2+ binding site [ion binding]; other site 448385022068 G-X-G motif; other site 448385022069 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022071 active site 448385022072 phosphorylation site [posttranslational modification] 448385022073 intermolecular recognition site; other site 448385022074 dimerization interface [polypeptide binding]; other site 448385022075 seryl-tRNA synthetase; Provisional; Region: PRK05431 448385022076 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 448385022077 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 448385022078 dimer interface [polypeptide binding]; other site 448385022079 active site 448385022080 motif 1; other site 448385022081 motif 2; other site 448385022082 motif 3; other site 448385022083 aconitate hydratase; Validated; Region: PRK09277 448385022084 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 448385022085 substrate binding site [chemical binding]; other site 448385022086 ligand binding site [chemical binding]; other site 448385022087 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 448385022088 substrate binding site [chemical binding]; other site 448385022089 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 448385022090 Hemerythrin-like domain; Region: Hr-like; cd12108 448385022091 Fe binding site [ion binding]; other site 448385022092 Sulfatase; Region: Sulfatase; cl17466 448385022093 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385022094 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385022095 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385022096 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 448385022097 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022098 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385022099 Haemagluttinin repeat; Region: Fil_haemagg; pfam05594 448385022100 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022101 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022103 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022104 active site 448385022105 phosphorylation site [posttranslational modification] 448385022106 intermolecular recognition site; other site 448385022107 dimerization interface [polypeptide binding]; other site 448385022108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022109 active site 448385022110 phosphorylation site [posttranslational modification] 448385022111 intermolecular recognition site; other site 448385022112 dimerization interface [polypeptide binding]; other site 448385022113 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 448385022114 tartrate dehydrogenase; Region: TTC; TIGR02089 448385022115 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 448385022116 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 448385022117 hexamer interface [polypeptide binding]; other site 448385022118 ligand binding site [chemical binding]; other site 448385022119 putative active site [active] 448385022120 NAD(P) binding site [chemical binding]; other site 448385022121 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385022122 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385022123 I-site; other site 448385022124 active site 448385022125 metal binding site [ion binding]; metal-binding site 448385022126 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 448385022127 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 448385022128 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 448385022129 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 448385022130 Cell division protein ZapA; Region: ZapA; pfam05164 448385022131 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 448385022132 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 448385022133 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385022134 catalytic residue [active] 448385022135 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 448385022136 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385022137 Walker A/P-loop; other site 448385022138 ATP binding site [chemical binding]; other site 448385022139 ABC transporter; Region: ABC_tran; pfam00005 448385022140 Q-loop/lid; other site 448385022141 ABC transporter signature motif; other site 448385022142 Walker B; other site 448385022143 D-loop; other site 448385022144 H-loop/switch region; other site 448385022145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385022146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385022147 active site 448385022148 ATP binding site [chemical binding]; other site 448385022149 substrate binding site [chemical binding]; other site 448385022150 activation loop (A-loop); other site 448385022151 DNA polymerase III subunit beta; Validated; Region: PRK05643 448385022152 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 448385022153 putative DNA binding surface [nucleotide binding]; other site 448385022154 dimer interface [polypeptide binding]; other site 448385022155 beta-clamp/clamp loader binding surface; other site 448385022156 beta-clamp/translesion DNA polymerase binding surface; other site 448385022157 recombination protein F; Reviewed; Region: recF; PRK00064 448385022158 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022159 Walker A/P-loop; other site 448385022160 ATP binding site [chemical binding]; other site 448385022161 Q-loop/lid; other site 448385022162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022163 ABC transporter signature motif; other site 448385022164 Walker B; other site 448385022165 D-loop; other site 448385022166 H-loop/switch region; other site 448385022167 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 448385022168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385022169 ATP binding site [chemical binding]; other site 448385022170 Mg2+ binding site [ion binding]; other site 448385022171 G-X-G motif; other site 448385022172 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 448385022173 anchoring element; other site 448385022174 dimer interface [polypeptide binding]; other site 448385022175 ATP binding site [chemical binding]; other site 448385022176 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 448385022177 active site 448385022178 putative metal-binding site [ion binding]; other site 448385022179 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 448385022180 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 448385022181 Clp amino terminal domain; Region: Clp_N; pfam02861 448385022182 Clp amino terminal domain; Region: Clp_N; pfam02861 448385022183 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022184 Walker A motif; other site 448385022185 ATP binding site [chemical binding]; other site 448385022186 Walker B motif; other site 448385022187 arginine finger; other site 448385022188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022189 Walker A motif; other site 448385022190 ATP binding site [chemical binding]; other site 448385022191 Walker B motif; other site 448385022192 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 448385022193 competence damage-inducible protein A; Provisional; Region: PRK00549 448385022194 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 448385022195 putative MPT binding site; other site 448385022196 Competence-damaged protein; Region: CinA; pfam02464 448385022197 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385022198 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 448385022199 Cytochrome C biogenesis protein; Region: CcmH; cl01179 448385022200 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 448385022201 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 448385022202 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 448385022203 active site 448385022204 catalytic residues [active] 448385022205 metal binding site [ion binding]; metal-binding site 448385022206 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385022207 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385022208 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385022209 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 448385022210 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385022211 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385022212 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 448385022213 protein binding site [polypeptide binding]; other site 448385022214 Phage tail tube protein; Region: Tail_tube; pfam10618 448385022215 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 448385022216 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385022217 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 448385022218 active site 448385022219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385022220 active site 448385022221 Tetratricopeptide repeat; Region: TPR_16; pfam13432 448385022222 recombination factor protein RarA; Reviewed; Region: PRK13342 448385022223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022224 Walker A motif; other site 448385022225 ATP binding site [chemical binding]; other site 448385022226 Walker B motif; other site 448385022227 arginine finger; other site 448385022228 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 448385022229 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385022230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385022231 catalytic residues [active] 448385022232 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 448385022233 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 448385022234 catalytic residue [active] 448385022235 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385022236 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385022237 ligand binding site [chemical binding]; other site 448385022238 flexible hinge region; other site 448385022239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385022240 Coenzyme A binding pocket [chemical binding]; other site 448385022241 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 448385022242 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 448385022243 substrate binding site [chemical binding]; other site 448385022244 hexamer interface [polypeptide binding]; other site 448385022245 metal binding site [ion binding]; metal-binding site 448385022246 DEAD-like helicases superfamily; Region: DEXDc; smart00487 448385022247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385022248 ATP binding site [chemical binding]; other site 448385022249 putative Mg++ binding site [ion binding]; other site 448385022250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385022251 nucleotide binding region [chemical binding]; other site 448385022252 ATP-binding site [chemical binding]; other site 448385022253 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 448385022254 AAA domain; Region: AAA_22; pfam13401 448385022255 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 448385022256 nucleotide binding site/active site [active] 448385022257 HIT family signature motif; other site 448385022258 catalytic residue [active] 448385022259 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 448385022260 PLD-like domain; Region: PLDc_2; pfam13091 448385022261 putative homodimer interface [polypeptide binding]; other site 448385022262 putative active site [active] 448385022263 catalytic site [active] 448385022264 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 448385022265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385022266 ATP binding site [chemical binding]; other site 448385022267 putative Mg++ binding site [ion binding]; other site 448385022268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385022269 nucleotide binding region [chemical binding]; other site 448385022270 ATP-binding site [chemical binding]; other site 448385022271 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385022272 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385022273 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385022274 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385022275 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385022276 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 448385022277 Sel1-like repeats; Region: SEL1; smart00671 448385022278 PAAR motif; Region: PAAR_motif; cl15808 448385022279 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 448385022280 Mrr N-terminal domain; Region: Mrr_N; pfam14338 448385022281 Mrr N-terminal domain; Region: Mrr_N; pfam14338 448385022282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022283 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385022284 Walker A motif; other site 448385022285 ATP binding site [chemical binding]; other site 448385022286 Walker B motif; other site 448385022287 arginine finger; other site 448385022288 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 448385022289 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385022290 ATP binding site [chemical binding]; other site 448385022291 putative Mg++ binding site [ion binding]; other site 448385022292 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385022293 nucleotide binding region [chemical binding]; other site 448385022294 ATP-binding site [chemical binding]; other site 448385022295 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 448385022296 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 448385022297 active site 448385022298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022299 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385022300 Walker A motif; other site 448385022301 ATP binding site [chemical binding]; other site 448385022302 Walker B motif; other site 448385022303 arginine finger; other site 448385022304 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385022305 PLD-like domain; Region: PLDc_2; pfam13091 448385022306 putative active site [active] 448385022307 catalytic site [active] 448385022308 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385022309 PLD-like domain; Region: PLDc_2; pfam13091 448385022310 putative active site [active] 448385022311 catalytic site [active] 448385022312 AAA domain; Region: AAA_11; pfam13086 448385022313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 448385022314 ATP binding site [chemical binding]; other site 448385022315 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 448385022316 AAA domain; Region: AAA_12; pfam13087 448385022317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385022318 Coenzyme A binding pocket [chemical binding]; other site 448385022319 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385022320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385022321 NAD(P) binding site [chemical binding]; other site 448385022322 active site 448385022323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385022324 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 448385022325 active site 448385022326 catalytic residues [active] 448385022327 BtpA family; Region: BtpA; cl00440 448385022328 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 448385022329 dimer interface [polypeptide binding]; other site 448385022330 active site 448385022331 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 448385022332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385022333 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 448385022334 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022335 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 448385022336 acyl-activating enzyme (AAE) consensus motif; other site 448385022337 AMP binding site [chemical binding]; other site 448385022338 FkbH-like domain; Region: FkbH; TIGR01686 448385022339 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 448385022340 Acid Phosphatase; Region: Acid_PPase; cl17256 448385022341 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 448385022342 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385022343 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385022344 catalytic residue [active] 448385022345 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385022346 Cytochrome P450; Region: p450; cl12078 448385022347 Methyltransferase domain; Region: Methyltransf_23; pfam13489 448385022348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 448385022349 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 448385022350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385022351 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 448385022352 acyl-activating enzyme (AAE) consensus motif; other site 448385022353 AMP binding site [chemical binding]; other site 448385022354 active site 448385022355 acyl-activating enzyme (AAE) consensus motif; other site 448385022356 CoA binding site [chemical binding]; other site 448385022357 acyl carrier protein; Provisional; Region: PRK07081 448385022358 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 448385022359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385022360 active site 448385022361 HIGH motif; other site 448385022362 nucleotide binding site [chemical binding]; other site 448385022363 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 448385022364 active site 448385022365 KMSKS motif; other site 448385022366 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 448385022367 anticodon binding site; other site 448385022368 tRNA binding surface [nucleotide binding]; other site 448385022369 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385022370 active site 448385022371 iron coordination sites [ion binding]; other site 448385022372 substrate binding pocket [chemical binding]; other site 448385022373 Cupin domain; Region: Cupin_2; pfam07883 448385022374 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 448385022375 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385022376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385022377 homodimer interface [polypeptide binding]; other site 448385022378 catalytic residue [active] 448385022379 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 448385022380 active site 448385022381 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 448385022382 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 448385022383 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385022384 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 448385022385 Peptidase family M28; Region: Peptidase_M28; pfam04389 448385022386 metal binding site [ion binding]; metal-binding site 448385022387 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385022388 Strictosidine synthase; Region: Str_synth; pfam03088 448385022389 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385022390 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385022391 TM-ABC transporter signature motif; other site 448385022392 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385022393 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 448385022394 TM-ABC transporter signature motif; other site 448385022395 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 448385022396 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 448385022397 Walker A/P-loop; other site 448385022398 ATP binding site [chemical binding]; other site 448385022399 Q-loop/lid; other site 448385022400 ABC transporter signature motif; other site 448385022401 Walker B; other site 448385022402 D-loop; other site 448385022403 H-loop/switch region; other site 448385022404 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 448385022405 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 448385022406 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 448385022407 putative ligand binding site [chemical binding]; other site 448385022408 putative dehydratase; Provisional; Region: PRK08211 448385022409 Dehydratase family; Region: ILVD_EDD; cl00340 448385022410 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 448385022411 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 448385022412 dimer interface [polypeptide binding]; other site 448385022413 NADP binding site [chemical binding]; other site 448385022414 catalytic residues [active] 448385022415 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 448385022416 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 448385022417 active site 448385022418 catalytic residues [active] 448385022419 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 448385022420 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 448385022421 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 448385022422 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 448385022423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385022424 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385022425 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 448385022426 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385022427 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 448385022428 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 448385022429 SdiA-regulated; Region: SdiA-regulated; cd09971 448385022430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385022431 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385022432 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385022433 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 448385022434 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385022435 inhibitor-cofactor binding pocket; inhibition site 448385022436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385022437 catalytic residue [active] 448385022438 Condensation domain; Region: Condensation; pfam00668 448385022439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022440 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 448385022441 acyl-activating enzyme (AAE) consensus motif; other site 448385022442 AMP binding site [chemical binding]; other site 448385022443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022444 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 448385022445 Condensation domain; Region: Condensation; pfam00668 448385022446 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022447 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022448 acyl-activating enzyme (AAE) consensus motif; other site 448385022449 AMP binding site [chemical binding]; other site 448385022450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022451 Condensation domain; Region: Condensation; pfam00668 448385022452 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022453 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022454 acyl-activating enzyme (AAE) consensus motif; other site 448385022455 AMP binding site [chemical binding]; other site 448385022456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022457 Condensation domain; Region: Condensation; pfam00668 448385022458 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022459 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385022460 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385022461 Condensation domain; Region: Condensation; pfam00668 448385022462 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022463 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385022464 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022465 acyl-activating enzyme (AAE) consensus motif; other site 448385022466 AMP binding site [chemical binding]; other site 448385022467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022468 Condensation domain; Region: Condensation; pfam00668 448385022469 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022470 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 448385022471 Condensation domain; Region: Condensation; pfam00668 448385022472 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022473 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022474 acyl-activating enzyme (AAE) consensus motif; other site 448385022475 AMP binding site [chemical binding]; other site 448385022476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022477 Condensation domain; Region: Condensation; pfam00668 448385022478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022480 Condensation domain; Region: Condensation; pfam00668 448385022481 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022482 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385022483 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022484 acyl-activating enzyme (AAE) consensus motif; other site 448385022485 AMP binding site [chemical binding]; other site 448385022486 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022487 Condensation domain; Region: Condensation; pfam00668 448385022488 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 448385022489 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 448385022490 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 448385022491 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 448385022492 active site 448385022493 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 448385022494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 448385022495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022496 Walker A/P-loop; other site 448385022497 ATP binding site [chemical binding]; other site 448385022498 ABC transporter signature motif; other site 448385022499 Walker B; other site 448385022500 D-loop; other site 448385022501 H-loop/switch region; other site 448385022502 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 448385022503 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 448385022504 active site 448385022505 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 448385022506 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 448385022507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385022508 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 448385022509 NAD(P) binding site [chemical binding]; other site 448385022510 active site 448385022511 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022512 acyl-CoA synthetase; Validated; Region: PRK05850 448385022513 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 448385022514 acyl-activating enzyme (AAE) consensus motif; other site 448385022515 active site 448385022516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022517 Condensation domain; Region: Condensation; pfam00668 448385022518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 448385022519 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 448385022520 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 448385022521 acyl-activating enzyme (AAE) consensus motif; other site 448385022522 AMP binding site [chemical binding]; other site 448385022523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 448385022524 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 448385022525 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385022526 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 448385022527 N-terminal plug; other site 448385022528 ligand-binding site [chemical binding]; other site 448385022529 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 448385022530 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 448385022531 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 448385022532 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022534 active site 448385022535 phosphorylation site [posttranslational modification] 448385022536 intermolecular recognition site; other site 448385022537 dimerization interface [polypeptide binding]; other site 448385022538 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 448385022539 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 448385022540 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 448385022541 dimer interface [polypeptide binding]; other site 448385022542 anticodon binding site; other site 448385022543 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 448385022544 homodimer interface [polypeptide binding]; other site 448385022545 motif 1; other site 448385022546 active site 448385022547 motif 2; other site 448385022548 GAD domain; Region: GAD; pfam02938 448385022549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 448385022550 active site 448385022551 motif 3; other site 448385022552 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 448385022553 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 448385022554 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 448385022555 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 448385022556 Protein of unknown function DUF58; Region: DUF58; pfam01882 448385022557 MoxR-like ATPases [General function prediction only]; Region: COG0714 448385022558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022559 Walker A motif; other site 448385022560 ATP binding site [chemical binding]; other site 448385022561 Walker B motif; other site 448385022562 arginine finger; other site 448385022563 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 448385022564 CAAX protease self-immunity; Region: Abi; pfam02517 448385022565 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 448385022566 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 448385022567 dimer interface [polypeptide binding]; other site 448385022568 ADP-ribose binding site [chemical binding]; other site 448385022569 active site 448385022570 nudix motif; other site 448385022571 metal binding site [ion binding]; metal-binding site 448385022572 NADH kinase; Region: PLN02929 448385022573 ATP-NAD kinase; Region: NAD_kinase; pfam01513 448385022574 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 448385022575 IHF dimer interface [polypeptide binding]; other site 448385022576 IHF - DNA interface [nucleotide binding]; other site 448385022577 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 448385022578 ABC1 family; Region: ABC1; cl17513 448385022579 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 448385022580 dimer interface [polypeptide binding]; other site 448385022581 Citrate synthase; Region: Citrate_synt; pfam00285 448385022582 active site 448385022583 citrylCoA binding site [chemical binding]; other site 448385022584 NADH binding [chemical binding]; other site 448385022585 cationic pore residues; other site 448385022586 oxalacetate/citrate binding site [chemical binding]; other site 448385022587 coenzyme A binding site [chemical binding]; other site 448385022588 catalytic triad [active] 448385022589 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385022590 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385022591 active site 448385022592 ATP binding site [chemical binding]; other site 448385022593 substrate binding site [chemical binding]; other site 448385022594 activation loop (A-loop); other site 448385022595 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 448385022596 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 448385022597 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385022598 Ligand Binding Site [chemical binding]; other site 448385022599 adenylosuccinate lyase; Provisional; Region: PRK07492 448385022600 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 448385022601 tetramer interface [polypeptide binding]; other site 448385022602 active site 448385022603 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 448385022604 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 448385022605 Predicted ATPase [General function prediction only]; Region: COG4637 448385022606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022607 Walker A/P-loop; other site 448385022608 ATP binding site [chemical binding]; other site 448385022609 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 448385022610 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 448385022611 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 448385022612 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 448385022613 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385022614 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 448385022615 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 448385022616 Active Sites [active] 448385022617 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 448385022618 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 448385022619 DTAP/Switch II; other site 448385022620 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 448385022621 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 448385022622 Prostaglandin dehydrogenases; Region: PGDH; cd05288 448385022623 NAD(P) binding site [chemical binding]; other site 448385022624 substrate binding site [chemical binding]; other site 448385022625 dimer interface [polypeptide binding]; other site 448385022626 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 448385022627 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 448385022628 Permease; Region: Permease; pfam02405 448385022629 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 448385022630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022631 Walker A/P-loop; other site 448385022632 ATP binding site [chemical binding]; other site 448385022633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385022634 ABC transporter signature motif; other site 448385022635 Walker B; other site 448385022636 D-loop; other site 448385022637 H-loop/switch region; other site 448385022638 TIGR02646 family protein; Region: TIGR02646 448385022639 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 448385022640 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385022641 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 448385022642 putative Iron-sulfur protein interface [polypeptide binding]; other site 448385022643 proximal heme binding site [chemical binding]; other site 448385022644 distal heme binding site [chemical binding]; other site 448385022645 putative dimer interface [polypeptide binding]; other site 448385022646 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 448385022647 L-aspartate oxidase; Provisional; Region: PRK06175 448385022648 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 448385022649 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 448385022650 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 448385022651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 448385022652 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 448385022653 TM-ABC transporter signature motif; other site 448385022654 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 448385022655 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 448385022656 putative ligand binding site [chemical binding]; other site 448385022657 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 448385022658 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 448385022659 RNA binding surface [nucleotide binding]; other site 448385022660 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 448385022661 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 448385022662 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 448385022663 intersubunit interface [polypeptide binding]; other site 448385022664 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385022665 active site 448385022666 substrate binding sites [chemical binding]; other site 448385022667 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 448385022668 Competence protein; Region: Competence; pfam03772 448385022669 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 448385022670 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 448385022671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385022672 FeS/SAM binding site; other site 448385022673 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 448385022674 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385022675 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385022676 catalytic residues [active] 448385022677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385022678 putative DNA binding site [nucleotide binding]; other site 448385022679 putative Zn2+ binding site [ion binding]; other site 448385022680 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 448385022681 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385022682 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385022683 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022684 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022685 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022686 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385022687 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385022688 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022689 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385022690 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022691 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022692 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 448385022693 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385022694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022695 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385022696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022697 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022698 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022699 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022700 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022701 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022702 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385022703 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385022704 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 448385022705 Catalytic dyad [active] 448385022706 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385022707 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022708 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022709 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385022710 FHA domain; Region: FHA; pfam00498 448385022711 phosphopeptide binding site; other site 448385022712 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385022713 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385022714 phosphopeptide binding site; other site 448385022715 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 448385022716 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385022717 active site 448385022718 glutamate 5-kinase; Region: proB; TIGR01027 448385022719 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 448385022720 nucleotide binding site [chemical binding]; other site 448385022721 homotetrameric interface [polypeptide binding]; other site 448385022722 putative phosphate binding site [ion binding]; other site 448385022723 putative allosteric binding site; other site 448385022724 PUA domain; Region: PUA; pfam01472 448385022725 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 448385022726 oligomer interface [polypeptide binding]; other site 448385022727 tandem repeat interface [polypeptide binding]; other site 448385022728 active site residues [active] 448385022729 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 448385022730 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 448385022731 tandem repeat interface [polypeptide binding]; other site 448385022732 oligomer interface [polypeptide binding]; other site 448385022733 active site residues [active] 448385022734 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 448385022735 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385022736 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385022737 Kelch domain; Region: Kelch; smart00612 448385022738 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385022739 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385022740 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 448385022741 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385022742 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385022743 active site 448385022744 catalytic tetrad [active] 448385022745 Cellulose binding domain; Region: CBM_2; cl17741 448385022746 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 448385022747 catalytic residues [active] 448385022748 dimer interface [polypeptide binding]; other site 448385022749 Isochorismatase family; Region: Isochorismatase; pfam00857 448385022750 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 448385022751 catalytic triad [active] 448385022752 dimer interface [polypeptide binding]; other site 448385022753 conserved cis-peptide bond; other site 448385022754 Pirin-related protein [General function prediction only]; Region: COG1741 448385022755 Pirin; Region: Pirin; pfam02678 448385022756 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 448385022757 LysR family transcriptional regulator; Provisional; Region: PRK14997 448385022758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385022759 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385022760 putative effector binding pocket; other site 448385022761 dimerization interface [polypeptide binding]; other site 448385022762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385022763 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385022764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385022765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 448385022766 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385022767 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385022768 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385022769 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385022770 conserved hypothetical protein; Region: TIGR02270 448385022771 conserved hypothetical protein; Region: TIGR02270 448385022772 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022773 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385022774 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 448385022775 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385022776 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385022777 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385022778 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 448385022779 Probable Catalytic site; other site 448385022780 metal-binding site 448385022781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385022782 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 448385022783 active site 448385022784 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 448385022785 active site 448385022786 Right handed beta helix region; Region: Beta_helix; pfam13229 448385022787 Uncharacterized conserved protein [Function unknown]; Region: COG3791 448385022788 von Willebrand factor; Region: vWF_A; pfam12450 448385022789 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385022790 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385022791 metal ion-dependent adhesion site (MIDAS); other site 448385022792 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 448385022793 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385022794 active site 448385022795 metal binding site [ion binding]; metal-binding site 448385022796 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 448385022797 catalytic motif [active] 448385022798 Zn binding site [ion binding]; other site 448385022799 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 448385022800 CotH protein; Region: CotH; pfam08757 448385022801 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 448385022802 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 448385022803 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 448385022804 YaeQ protein; Region: YaeQ; cl01913 448385022805 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 448385022806 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385022807 SnoaL-like domain; Region: SnoaL_3; pfam13474 448385022808 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 448385022809 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385022810 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385022811 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385022812 active site 448385022813 substrate binding sites [chemical binding]; other site 448385022814 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 448385022815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022816 NACHT domain; Region: NACHT; pfam05729 448385022817 Walker A motif; other site 448385022818 ATP binding site [chemical binding]; other site 448385022819 Walker B motif; other site 448385022820 arginine finger; other site 448385022821 WD domain, G-beta repeat; Region: WD40; pfam00400 448385022822 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385022823 WD domain, G-beta repeat; Region: WD40; pfam00400 448385022824 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385022825 structural tetrad; other site 448385022826 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 448385022827 structural tetrad; other site 448385022828 FOG: WD40 repeat [General function prediction only]; Region: COG2319 448385022829 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 448385022830 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 448385022831 substrate binding site [chemical binding]; other site 448385022832 trimer interface [polypeptide binding]; other site 448385022833 hexamer (dimer of trimers) interface [polypeptide binding]; other site 448385022834 Mn binding site [ion binding]; other site 448385022835 Transcriptional regulators [Transcription]; Region: PurR; COG1609 448385022836 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 448385022837 DNA binding site [nucleotide binding] 448385022838 domain linker motif; other site 448385022839 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385022840 ligand binding site [chemical binding]; other site 448385022841 dimerization interface [polypeptide binding]; other site 448385022842 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385022843 GAF domain; Region: GAF; pfam01590 448385022844 GAF domain; Region: GAF_3; pfam13492 448385022845 GAF domain; Region: GAF_2; pfam13185 448385022846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385022847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385022848 metal binding site [ion binding]; metal-binding site 448385022849 active site 448385022850 I-site; other site 448385022851 Family description; Region: VCBS; pfam13517 448385022852 CAAX protease self-immunity; Region: Abi; pfam02517 448385022853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385022854 dimerization interface [polypeptide binding]; other site 448385022855 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385022856 dimer interface [polypeptide binding]; other site 448385022857 phosphorylation site [posttranslational modification] 448385022858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385022859 ATP binding site [chemical binding]; other site 448385022860 G-X-G motif; other site 448385022861 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385022862 putative active site [active] 448385022863 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 448385022864 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 448385022865 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 448385022866 NodB motif; other site 448385022867 active site 448385022868 catalytic site [active] 448385022869 metal binding site [ion binding]; metal-binding site 448385022870 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 448385022871 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 448385022872 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385022873 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385022874 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385022875 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385022876 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385022877 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385022878 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385022879 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385022880 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385022881 PEGA domain; Region: PEGA; pfam08308 448385022882 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 448385022883 substrate binding site [chemical binding]; other site 448385022884 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 448385022885 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 448385022886 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385022887 FIST N domain; Region: FIST; pfam08495 448385022888 Uncharacterized conserved protein [Function unknown]; Region: COG3287 448385022889 FIST C domain; Region: FIST_C; pfam10442 448385022890 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 448385022891 anti sigma factor interaction site; other site 448385022892 regulatory phosphorylation site [posttranslational modification]; other site 448385022893 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 448385022894 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385022895 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385022896 active site 448385022897 ATP binding site [chemical binding]; other site 448385022898 substrate binding site [chemical binding]; other site 448385022899 activation loop (A-loop); other site 448385022900 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 448385022901 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 448385022902 protein binding site [polypeptide binding]; other site 448385022903 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385022904 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385022905 active site 448385022906 ATP binding site [chemical binding]; other site 448385022907 substrate binding site [chemical binding]; other site 448385022908 activation loop (A-loop); other site 448385022909 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 448385022910 E-class dimer interface [polypeptide binding]; other site 448385022911 P-class dimer interface [polypeptide binding]; other site 448385022912 active site 448385022913 Cu2+ binding site [ion binding]; other site 448385022914 Zn2+ binding site [ion binding]; other site 448385022915 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022917 active site 448385022918 phosphorylation site [posttranslational modification] 448385022919 intermolecular recognition site; other site 448385022920 dimerization interface [polypeptide binding]; other site 448385022921 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385022922 cyclase homology domain; Region: CHD; cd07302 448385022923 nucleotidyl binding site; other site 448385022924 metal binding site [ion binding]; metal-binding site 448385022925 dimer interface [polypeptide binding]; other site 448385022926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385022927 dimer interface [polypeptide binding]; other site 448385022928 phosphorylation site [posttranslational modification] 448385022929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385022930 ATP binding site [chemical binding]; other site 448385022931 Mg2+ binding site [ion binding]; other site 448385022932 G-X-G motif; other site 448385022933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022934 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022935 active site 448385022936 phosphorylation site [posttranslational modification] 448385022937 intermolecular recognition site; other site 448385022938 dimerization interface [polypeptide binding]; other site 448385022939 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 448385022940 HSP70 interaction site [polypeptide binding]; other site 448385022941 SnoaL-like domain; Region: SnoaL_2; pfam12680 448385022942 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 448385022943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022944 Walker A motif; other site 448385022945 ATP binding site [chemical binding]; other site 448385022946 Walker B motif; other site 448385022947 arginine finger; other site 448385022948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385022949 Walker A motif; other site 448385022950 ATP binding site [chemical binding]; other site 448385022951 Walker B motif; other site 448385022952 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 448385022953 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 448385022954 active site 448385022955 Beta propeller domain; Region: Beta_propel; pfam09826 448385022956 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385022957 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 448385022958 reactive center loop; other site 448385022959 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385022960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385022961 LysR substrate binding domain; Region: LysR_substrate; pfam03466 448385022962 dimerization interface [polypeptide binding]; other site 448385022963 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 448385022964 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385022965 Response regulator receiver domain; Region: Response_reg; pfam00072 448385022966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385022967 active site 448385022968 phosphorylation site [posttranslational modification] 448385022969 intermolecular recognition site; other site 448385022970 dimerization interface [polypeptide binding]; other site 448385022971 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385022972 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 448385022973 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385022974 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 448385022975 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 448385022976 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385022977 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385022978 active site 448385022979 ATP binding site [chemical binding]; other site 448385022980 substrate binding site [chemical binding]; other site 448385022981 activation loop (A-loop); other site 448385022982 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 448385022983 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 448385022984 dimer interface [polypeptide binding]; other site 448385022985 active site 448385022986 transketolase; Reviewed; Region: PRK05899 448385022987 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 448385022988 TPP-binding site [chemical binding]; other site 448385022989 dimer interface [polypeptide binding]; other site 448385022990 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 448385022991 PYR/PP interface [polypeptide binding]; other site 448385022992 dimer interface [polypeptide binding]; other site 448385022993 TPP binding site [chemical binding]; other site 448385022994 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 448385022995 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 448385022996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385022997 active site 448385022998 metal binding site [ion binding]; metal-binding site 448385022999 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385023000 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023001 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023002 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023004 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385023005 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 448385023006 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023007 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023008 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023009 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023010 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023011 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023012 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023013 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385023014 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 448385023015 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023016 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023017 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023018 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023019 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023021 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 448385023022 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023023 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023024 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 448385023025 HEPN domain; Region: HEPN; cl00824 448385023026 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385023027 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385023028 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385023029 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 448385023030 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385023031 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385023032 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385023033 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385023034 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 448385023035 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 448385023036 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 448385023037 active site 448385023038 catalytic residues [active] 448385023039 metal binding site [ion binding]; metal-binding site 448385023040 Helix-turn-helix domain; Region: HTH_36; pfam13730 448385023041 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385023042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023043 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385023044 DNA binding residues [nucleotide binding] 448385023045 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385023046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385023048 DNA binding residues [nucleotide binding] 448385023049 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023050 PEGA domain; Region: PEGA; pfam08308 448385023051 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 448385023052 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 448385023053 [4Fe-4S] binding site [ion binding]; other site 448385023054 molybdopterin cofactor binding site; other site 448385023055 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 448385023056 molybdopterin cofactor binding site; other site 448385023057 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 448385023058 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 448385023059 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 448385023060 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 448385023061 nitrite reductase subunit NirD; Provisional; Region: PRK14989 448385023062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385023063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 448385023064 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385023065 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385023066 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 448385023067 PAS fold; Region: PAS_4; pfam08448 448385023068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385023069 putative active site [active] 448385023070 heme pocket [chemical binding]; other site 448385023071 GAF domain; Region: GAF; cl17456 448385023072 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385023073 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385023074 GAF domain; Region: GAF_2; pfam13185 448385023075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385023076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385023077 dimer interface [polypeptide binding]; other site 448385023078 phosphorylation site [posttranslational modification] 448385023079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023080 ATP binding site [chemical binding]; other site 448385023081 Mg2+ binding site [ion binding]; other site 448385023082 G-X-G motif; other site 448385023083 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023085 active site 448385023086 phosphorylation site [posttranslational modification] 448385023087 intermolecular recognition site; other site 448385023088 dimerization interface [polypeptide binding]; other site 448385023089 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 448385023090 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385023091 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 448385023092 Protein of unknown function, DUF488; Region: DUF488; pfam04343 448385023093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023094 ATP binding site [chemical binding]; other site 448385023095 Mg2+ binding site [ion binding]; other site 448385023096 G-X-G motif; other site 448385023097 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 448385023098 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 448385023099 PAS fold; Region: PAS_4; pfam08448 448385023100 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385023101 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 448385023102 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385023103 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385023104 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 448385023105 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 448385023106 Phosphotransferase enzyme family; Region: APH; pfam01636 448385023107 CBD_II domain; Region: CBD_II; smart00637 448385023108 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 448385023109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023110 Walker A/P-loop; other site 448385023111 ATP binding site [chemical binding]; other site 448385023112 Q-loop/lid; other site 448385023113 ABC transporter signature motif; other site 448385023114 Walker B; other site 448385023115 D-loop; other site 448385023116 H-loop/switch region; other site 448385023117 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 448385023118 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 448385023119 active site 448385023120 substrate binding site [chemical binding]; other site 448385023121 cosubstrate binding site; other site 448385023122 catalytic site [active] 448385023123 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023124 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023125 active site 448385023126 ATP binding site [chemical binding]; other site 448385023127 substrate binding site [chemical binding]; other site 448385023128 activation loop (A-loop); other site 448385023129 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 448385023130 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 448385023131 dimerization interface [polypeptide binding]; other site 448385023132 putative ATP binding site [chemical binding]; other site 448385023133 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 448385023134 active site 448385023135 8-oxo-dGMP binding site [chemical binding]; other site 448385023136 nudix motif; other site 448385023137 metal binding site [ion binding]; metal-binding site 448385023138 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 448385023139 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 448385023140 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385023141 Putative zinc-finger; Region: zf-HC2; pfam13490 448385023142 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 448385023143 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385023144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023145 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 448385023146 sugar binding site [chemical binding]; other site 448385023147 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 448385023148 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 448385023149 signal recognition particle protein; Provisional; Region: PRK10867 448385023150 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 448385023151 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 448385023152 P loop; other site 448385023153 GTP binding site [chemical binding]; other site 448385023154 Signal peptide binding domain; Region: SRP_SPB; pfam02978 448385023155 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 448385023156 putative ligand binding site [chemical binding]; other site 448385023157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023158 AAA domain; Region: AAA_23; pfam13476 448385023159 Walker A/P-loop; other site 448385023160 ATP binding site [chemical binding]; other site 448385023161 Uncharacterized conserved protein [Function unknown]; Region: COG4938 448385023162 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 448385023163 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 448385023164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023165 Walker A/P-loop; other site 448385023166 ATP binding site [chemical binding]; other site 448385023167 Q-loop/lid; other site 448385023168 ABC transporter signature motif; other site 448385023169 Walker B; other site 448385023170 D-loop; other site 448385023171 H-loop/switch region; other site 448385023172 ABC transporter; Region: ABC_tran_2; pfam12848 448385023173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385023174 Peptidase S46; Region: Peptidase_S46; pfam10459 448385023175 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 448385023176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385023177 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 448385023178 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 448385023179 short chain dehydrogenase; Provisional; Region: PRK06172 448385023180 classical (c) SDRs; Region: SDR_c; cd05233 448385023181 NAD(P) binding site [chemical binding]; other site 448385023182 active site 448385023183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385023184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385023185 Cytochrome P450; Region: p450; cl12078 448385023186 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385023187 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 448385023188 substrate binding pocket [chemical binding]; other site 448385023189 substrate-Mg2+ binding site; other site 448385023190 aspartate-rich region 1; other site 448385023191 aspartate-rich region 2; other site 448385023192 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023193 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023194 active site 448385023195 ATP binding site [chemical binding]; other site 448385023196 substrate binding site [chemical binding]; other site 448385023197 activation loop (A-loop); other site 448385023198 AAA ATPase domain; Region: AAA_16; pfam13191 448385023199 Predicted ATPase [General function prediction only]; Region: COG3899 448385023200 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385023201 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385023202 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385023203 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 448385023204 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 448385023205 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023206 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023207 active site 448385023208 ATP binding site [chemical binding]; other site 448385023209 substrate binding site [chemical binding]; other site 448385023210 activation loop (A-loop); other site 448385023211 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023212 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023213 active site 448385023214 phosphorylation site [posttranslational modification] 448385023215 intermolecular recognition site; other site 448385023216 dimerization interface [polypeptide binding]; other site 448385023217 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 448385023218 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385023219 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 448385023220 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 448385023221 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 448385023222 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 448385023223 Family description; Region: VCBS; pfam13517 448385023224 Family description; Region: VCBS; pfam13517 448385023225 Family description; Region: VCBS; pfam13517 448385023226 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 448385023227 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 448385023228 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385023229 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385023230 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 448385023231 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 448385023232 NAD(P) binding site [chemical binding]; other site 448385023233 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 448385023234 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385023235 Walker A/P-loop; other site 448385023236 ATP binding site [chemical binding]; other site 448385023237 Q-loop/lid; other site 448385023238 ABC transporter signature motif; other site 448385023239 Walker B; other site 448385023240 D-loop; other site 448385023241 H-loop/switch region; other site 448385023242 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 448385023243 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 448385023244 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 448385023245 Walker A/P-loop; other site 448385023246 ATP binding site [chemical binding]; other site 448385023247 Q-loop/lid; other site 448385023248 ABC transporter signature motif; other site 448385023249 Walker B; other site 448385023250 D-loop; other site 448385023251 H-loop/switch region; other site 448385023252 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 448385023253 Tudor-like domain present in plant sequences; Region: Agenet; smart00743 448385023254 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 448385023255 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 448385023256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385023257 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 448385023258 putative effector binding pocket; other site 448385023259 putative dimerization interface [polypeptide binding]; other site 448385023260 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385023261 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385023262 active site 448385023263 catalytic tetrad [active] 448385023264 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 448385023265 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 448385023266 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385023267 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 448385023268 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 448385023269 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 448385023270 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 448385023271 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385023272 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 448385023273 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 448385023274 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 448385023275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385023276 Ligand Binding Site [chemical binding]; other site 448385023277 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 448385023278 Ligand Binding Site [chemical binding]; other site 448385023279 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 448385023280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385023281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385023282 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 448385023283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385023284 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 448385023285 dimerization interface [polypeptide binding]; other site 448385023286 substrate binding pocket [chemical binding]; other site 448385023287 Protein of unknown function (DUF998); Region: DUF998; pfam06197 448385023288 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 448385023289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385023290 putative NAD(P) binding site [chemical binding]; other site 448385023291 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 448385023292 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 448385023293 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 448385023294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385023295 hypothetical protein; Provisional; Region: PRK09040 448385023296 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 448385023297 ligand binding site [chemical binding]; other site 448385023298 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 448385023299 Protein phosphatase 2C; Region: PP2C; pfam00481 448385023300 active site 448385023301 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 448385023302 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385023303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 448385023304 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 448385023305 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 448385023306 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385023307 acyl-activating enzyme (AAE) consensus motif; other site 448385023308 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 448385023309 Stringent starvation protein B; Region: SspB; cl01120 448385023310 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 448385023311 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 448385023312 TM-ABC transporter signature motif; other site 448385023313 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 448385023314 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 448385023315 Walker A/P-loop; other site 448385023316 ATP binding site [chemical binding]; other site 448385023317 Q-loop/lid; other site 448385023318 ABC transporter signature motif; other site 448385023319 Walker B; other site 448385023320 D-loop; other site 448385023321 H-loop/switch region; other site 448385023322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 448385023323 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 448385023324 Walker A/P-loop; other site 448385023325 ATP binding site [chemical binding]; other site 448385023326 Q-loop/lid; other site 448385023327 ABC transporter signature motif; other site 448385023328 Walker B; other site 448385023329 D-loop; other site 448385023330 H-loop/switch region; other site 448385023331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023332 active site 448385023333 phosphorylation site [posttranslational modification] 448385023334 intermolecular recognition site; other site 448385023335 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 448385023336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 448385023337 DXD motif; other site 448385023338 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 448385023339 IHF dimer interface [polypeptide binding]; other site 448385023340 IHF - DNA interface [nucleotide binding]; other site 448385023341 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 448385023342 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385023343 DNA binding residues [nucleotide binding] 448385023344 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 448385023345 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 448385023346 dimer interface [polypeptide binding]; other site 448385023347 ssDNA binding site [nucleotide binding]; other site 448385023348 tetramer (dimer of dimers) interface [polypeptide binding]; other site 448385023349 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 448385023350 MgtE intracellular N domain; Region: MgtE_N; smart00924 448385023351 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 448385023352 Divalent cation transporter; Region: MgtE; pfam01769 448385023353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 448385023354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023355 active site 448385023356 phosphorylation site [posttranslational modification] 448385023357 intermolecular recognition site; other site 448385023358 dimerization interface [polypeptide binding]; other site 448385023359 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 448385023360 DNA binding site [nucleotide binding] 448385023361 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385023362 HEAT repeats; Region: HEAT_2; pfam13646 448385023363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385023364 S-adenosylmethionine binding site [chemical binding]; other site 448385023365 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385023366 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 448385023367 active site 448385023368 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385023369 GAF domain; Region: GAF; pfam01590 448385023370 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 448385023371 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 448385023372 NAD(P) binding site [chemical binding]; other site 448385023373 catalytic residues [active] 448385023374 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 448385023375 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 448385023376 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385023377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385023378 catalytic residue [active] 448385023379 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385023380 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385023381 phosphopeptide binding site; other site 448385023382 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 448385023383 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 448385023384 metal binding site [ion binding]; metal-binding site 448385023385 active site 448385023386 I-site; other site 448385023387 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 448385023388 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 448385023389 putative active site [active] 448385023390 putative dimer interface [polypeptide binding]; other site 448385023391 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 448385023392 substrate binding site [chemical binding]; other site 448385023393 active site 448385023394 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 448385023395 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 448385023396 metal binding site [ion binding]; metal-binding site 448385023397 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 448385023398 ApbE family; Region: ApbE; pfam02424 448385023399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 448385023400 enoyl-CoA hydratase; Provisional; Region: PRK07657 448385023401 substrate binding site [chemical binding]; other site 448385023402 oxyanion hole (OAH) forming residues; other site 448385023403 trimer interface [polypeptide binding]; other site 448385023404 Peptidase family M1; Region: Peptidase_M1; pfam01433 448385023405 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 448385023406 Zn binding site [ion binding]; other site 448385023407 HEAT repeats; Region: HEAT_2; pfam13646 448385023408 HEAT repeats; Region: HEAT_2; pfam13646 448385023409 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 448385023410 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 448385023411 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 448385023412 FAD binding site [chemical binding]; other site 448385023413 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385023414 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385023415 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385023416 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385023417 FG-GAP repeat; Region: FG-GAP_2; pfam14312 448385023418 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385023419 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385023420 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385023421 catalytic residue [active] 448385023422 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 448385023423 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 448385023424 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 448385023425 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385023426 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385023427 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 448385023428 Right handed beta helix region; Region: Beta_helix; pfam13229 448385023429 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 448385023430 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385023431 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385023432 Walker A/P-loop; other site 448385023433 ATP binding site [chemical binding]; other site 448385023434 Q-loop/lid; other site 448385023435 ABC transporter signature motif; other site 448385023436 Walker B; other site 448385023437 D-loop; other site 448385023438 H-loop/switch region; other site 448385023439 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385023440 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385023441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385023442 dimer interface [polypeptide binding]; other site 448385023443 phosphorylation site [posttranslational modification] 448385023444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023445 ATP binding site [chemical binding]; other site 448385023446 Mg2+ binding site [ion binding]; other site 448385023447 G-X-G motif; other site 448385023448 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 448385023449 Kelch domain; Region: Kelch; smart00612 448385023450 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385023451 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 448385023452 GAF domain; Region: GAF; pfam01590 448385023453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385023454 Walker A motif; other site 448385023455 ATP binding site [chemical binding]; other site 448385023456 Walker B motif; other site 448385023457 arginine finger; other site 448385023458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385023459 Kelch motif; Region: Kelch_1; pfam01344 448385023460 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385023461 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385023462 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385023463 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385023464 Galactose oxidase, central domain; Region: Kelch_3; cl02701 448385023465 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385023466 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 448385023467 structural tetrad; other site 448385023468 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385023469 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 448385023470 Kelch domain; Region: Kelch; smart00612 448385023471 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023472 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023473 active site 448385023474 ATP binding site [chemical binding]; other site 448385023475 substrate binding site [chemical binding]; other site 448385023476 activation loop (A-loop); other site 448385023477 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385023478 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385023480 TPR motif; other site 448385023481 binding surface 448385023482 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385023485 binding surface 448385023486 TPR motif; other site 448385023487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385023490 binding surface 448385023491 TPR motif; other site 448385023492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023494 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023495 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023496 active site 448385023497 ATP binding site [chemical binding]; other site 448385023498 substrate binding site [chemical binding]; other site 448385023499 activation loop (A-loop); other site 448385023500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385023501 TPR motif; other site 448385023502 binding surface 448385023503 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 448385023504 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 448385023505 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385023506 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 448385023507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 448385023508 Walker A/P-loop; other site 448385023509 ATP binding site [chemical binding]; other site 448385023510 Q-loop/lid; other site 448385023511 AAA domain; Region: AAA_21; pfam13304 448385023512 ABC transporter signature motif; other site 448385023513 Walker B; other site 448385023514 D-loop; other site 448385023515 H-loop/switch region; other site 448385023516 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 448385023517 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 448385023518 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 448385023519 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 448385023520 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 448385023521 DNA binding residues [nucleotide binding] 448385023522 putative dimer interface [polypeptide binding]; other site 448385023523 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 448385023524 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 448385023525 hypothetical protein; Provisional; Region: PRK07236 448385023526 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 448385023527 active site 448385023528 FMN binding site [chemical binding]; other site 448385023529 substrate binding site [chemical binding]; other site 448385023530 homotetramer interface [polypeptide binding]; other site 448385023531 catalytic residue [active] 448385023532 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385023533 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385023534 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385023535 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385023536 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385023537 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385023538 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 448385023539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385023540 NAD(P) binding site [chemical binding]; other site 448385023541 active site 448385023542 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 448385023543 proline aminopeptidase P II; Provisional; Region: PRK10879 448385023544 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 448385023545 active site 448385023546 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 448385023547 active site 448385023548 catalytic triad [active] 448385023549 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385023550 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385023551 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385023552 protein binding site [polypeptide binding]; other site 448385023553 DNA polymerase I; Provisional; Region: PRK05755 448385023554 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 448385023555 active site 448385023556 metal binding site 1 [ion binding]; metal-binding site 448385023557 putative 5' ssDNA interaction site; other site 448385023558 metal binding site 3; metal-binding site 448385023559 metal binding site 2 [ion binding]; metal-binding site 448385023560 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 448385023561 putative DNA binding site [nucleotide binding]; other site 448385023562 putative metal binding site [ion binding]; other site 448385023563 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 448385023564 active site 448385023565 substrate binding site [chemical binding]; other site 448385023566 catalytic site [active] 448385023567 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 448385023568 active site 448385023569 DNA binding site [nucleotide binding] 448385023570 catalytic site [active] 448385023571 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 448385023572 DNA polymerase I; Provisional; Region: PRK05755 448385023573 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 448385023574 active site 448385023575 substrate binding site [chemical binding]; other site 448385023576 catalytic site [active] 448385023577 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 448385023578 DNA binding site [nucleotide binding] 448385023579 active site 448385023580 catalytic site [active] 448385023581 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 448385023582 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 448385023583 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 448385023584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385023586 DNA binding residues [nucleotide binding] 448385023587 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 448385023588 C-terminal peptidase (prc); Region: prc; TIGR00225 448385023589 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 448385023590 protein binding site [polypeptide binding]; other site 448385023591 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 448385023592 Catalytic dyad [active] 448385023593 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 448385023594 hydroxyglutarate oxidase; Provisional; Region: PRK11728 448385023595 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 448385023596 hypothetical protein; Provisional; Region: PRK07208 448385023597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 448385023598 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 448385023599 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 448385023600 substrate binding site [chemical binding]; other site 448385023601 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 448385023602 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 448385023603 substrate binding site [chemical binding]; other site 448385023604 ligand binding site [chemical binding]; other site 448385023605 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 448385023606 TAP-like protein; Region: Abhydrolase_4; pfam08386 448385023607 Tir chaperone protein (CesT) family; Region: CesT; cl08444 448385023608 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 448385023609 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 448385023610 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 448385023611 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 448385023612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023614 active site 448385023615 ATP binding site [chemical binding]; other site 448385023616 substrate binding site [chemical binding]; other site 448385023617 activation loop (A-loop); other site 448385023618 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 448385023619 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385023620 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 448385023621 acyl-activating enzyme (AAE) consensus motif; other site 448385023622 putative AMP binding site [chemical binding]; other site 448385023623 putative active site [active] 448385023624 putative CoA binding site [chemical binding]; other site 448385023625 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 448385023626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385023627 motif II; other site 448385023628 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 448385023629 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 448385023630 tandem repeat interface [polypeptide binding]; other site 448385023631 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 448385023632 oligomer interface [polypeptide binding]; other site 448385023633 active site residues [active] 448385023634 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 448385023635 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 448385023636 tandem repeat interface [polypeptide binding]; other site 448385023637 oligomer interface [polypeptide binding]; other site 448385023638 active site residues [active] 448385023639 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385023640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385023641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023642 ATP binding site [chemical binding]; other site 448385023643 Mg2+ binding site [ion binding]; other site 448385023644 G-X-G motif; other site 448385023645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 448385023646 active site 448385023647 phosphorylation site [posttranslational modification] 448385023648 intermolecular recognition site; other site 448385023649 dimerization interface [polypeptide binding]; other site 448385023650 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 448385023651 HlyD family secretion protein; Region: HlyD_3; pfam13437 448385023652 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 448385023653 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 448385023654 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023656 active site 448385023657 phosphorylation site [posttranslational modification] 448385023658 intermolecular recognition site; other site 448385023659 dimerization interface [polypeptide binding]; other site 448385023660 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385023661 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385023662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385023663 dimer interface [polypeptide binding]; other site 448385023664 phosphorylation site [posttranslational modification] 448385023665 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 448385023666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023667 ATP binding site [chemical binding]; other site 448385023668 Mg2+ binding site [ion binding]; other site 448385023669 G-X-G motif; other site 448385023670 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385023671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023672 active site 448385023673 phosphorylation site [posttranslational modification] 448385023674 intermolecular recognition site; other site 448385023675 dimerization interface [polypeptide binding]; other site 448385023676 PAS fold; Region: PAS_4; pfam08448 448385023677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385023678 putative active site [active] 448385023679 heme pocket [chemical binding]; other site 448385023680 PAS fold; Region: PAS_4; pfam08448 448385023681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385023682 putative active site [active] 448385023683 heme pocket [chemical binding]; other site 448385023684 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 448385023685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385023686 dimer interface [polypeptide binding]; other site 448385023687 phosphorylation site [posttranslational modification] 448385023688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023689 ATP binding site [chemical binding]; other site 448385023690 Mg2+ binding site [ion binding]; other site 448385023691 G-X-G motif; other site 448385023692 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 448385023693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023694 active site 448385023695 phosphorylation site [posttranslational modification] 448385023696 intermolecular recognition site; other site 448385023697 dimerization interface [polypeptide binding]; other site 448385023698 Domain of unknown function (DUF334); Region: DUF334; pfam03904 448385023699 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 448385023700 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385023701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023702 active site 448385023703 phosphorylation site [posttranslational modification] 448385023704 intermolecular recognition site; other site 448385023705 dimerization interface [polypeptide binding]; other site 448385023706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385023707 Walker A motif; other site 448385023708 ATP binding site [chemical binding]; other site 448385023709 Walker B motif; other site 448385023710 arginine finger; other site 448385023711 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385023712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023713 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023714 active site 448385023715 phosphorylation site [posttranslational modification] 448385023716 intermolecular recognition site; other site 448385023717 dimerization interface [polypeptide binding]; other site 448385023718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385023719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385023720 non-specific DNA binding site [nucleotide binding]; other site 448385023721 salt bridge; other site 448385023722 sequence-specific DNA binding site [nucleotide binding]; other site 448385023723 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 448385023724 Domain of unknown function (DUF955); Region: DUF955; pfam06114 448385023725 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 448385023726 malate synthase A; Region: malate_syn_A; TIGR01344 448385023727 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 448385023728 active site 448385023729 isocitrate lyase; Provisional; Region: PRK15063 448385023730 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 448385023731 tetramer interface [polypeptide binding]; other site 448385023732 active site 448385023733 Mg2+/Mn2+ binding site [ion binding]; other site 448385023734 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 448385023735 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023736 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023737 active site 448385023738 ATP binding site [chemical binding]; other site 448385023739 substrate binding site [chemical binding]; other site 448385023740 activation loop (A-loop); other site 448385023741 AAA ATPase domain; Region: AAA_16; pfam13191 448385023742 Predicted ATPase [General function prediction only]; Region: COG3899 448385023743 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023746 active site 448385023747 ATP binding site [chemical binding]; other site 448385023748 substrate binding site [chemical binding]; other site 448385023749 activation loop (A-loop); other site 448385023750 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385023751 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385023752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385023753 binding surface 448385023754 TPR motif; other site 448385023755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023757 active site 448385023758 ATP binding site [chemical binding]; other site 448385023759 substrate binding site [chemical binding]; other site 448385023760 activation loop (A-loop); other site 448385023761 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 448385023762 dinuclear metal binding motif [ion binding]; other site 448385023763 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385023764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385023766 DNA binding residues [nucleotide binding] 448385023767 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 448385023768 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 448385023769 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 448385023770 ATP-grasp domain; Region: ATP-grasp_4; cl17255 448385023771 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 448385023772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023773 active site 448385023774 ATP binding site [chemical binding]; other site 448385023775 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385023776 AAA ATPase domain; Region: AAA_16; pfam13191 448385023777 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385023778 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385023779 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385023780 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385023781 phosphopeptide binding site; other site 448385023782 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385023783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385023784 Walker A motif; other site 448385023785 ATP binding site [chemical binding]; other site 448385023786 Walker B motif; other site 448385023787 arginine finger; other site 448385023788 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385023789 SIR2-like domain; Region: SIR2_2; pfam13289 448385023790 TIR domain; Region: TIR_2; pfam13676 448385023791 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385023792 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 448385023793 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 448385023794 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 448385023795 high affinity sulphate transporter 1; Region: sulP; TIGR00815 448385023796 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 448385023797 Sulfate transporter family; Region: Sulfate_transp; pfam00916 448385023798 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 448385023799 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 448385023800 TfuA-like protein; Region: TfuA; pfam07812 448385023801 Uncharacterized conserved protein [Function unknown]; Region: COG1944 448385023802 YcaO-like family; Region: YcaO; pfam02624 448385023803 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 448385023804 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 448385023805 PYR/PP interface [polypeptide binding]; other site 448385023806 dimer interface [polypeptide binding]; other site 448385023807 TPP binding site [chemical binding]; other site 448385023808 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 448385023809 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 448385023810 TPP-binding site [chemical binding]; other site 448385023811 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 448385023812 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 448385023813 active site 448385023814 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 448385023815 NB-ARC domain; Region: NB-ARC; pfam00931 448385023816 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 448385023817 PEGA domain; Region: PEGA; pfam08308 448385023818 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 448385023819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385023821 DNA binding residues [nucleotide binding] 448385023822 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 448385023823 DNA binding site [nucleotide binding] 448385023824 active site 448385023825 Int/Topo IB signature motif; other site 448385023826 catalytic residues [active] 448385023827 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 448385023828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023830 Walker A/P-loop; other site 448385023831 Walker A/P-loop; other site 448385023832 ATP binding site [chemical binding]; other site 448385023833 ATP binding site [chemical binding]; other site 448385023834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385023835 ABC transporter signature motif; other site 448385023836 Walker B; other site 448385023837 D-loop; other site 448385023838 H-loop/switch region; other site 448385023839 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 448385023840 putative active site [active] 448385023841 putative metal-binding site [ion binding]; other site 448385023842 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 448385023843 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 448385023844 Catalytic site [active] 448385023845 transposase/IS protein; Provisional; Region: PRK09183 448385023846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385023847 Walker A motif; other site 448385023848 ATP binding site [chemical binding]; other site 448385023849 Walker B motif; other site 448385023850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 448385023851 DNA binding residues [nucleotide binding] 448385023852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 448385023853 Integrase core domain; Region: rve; pfam00665 448385023854 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 448385023855 transmembrane helices; other site 448385023856 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385023857 hypothetical protein; Provisional; Region: PRK08609 448385023858 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 448385023859 active site 448385023860 primer binding site [nucleotide binding]; other site 448385023861 NTP binding site [chemical binding]; other site 448385023862 metal binding triad [ion binding]; metal-binding site 448385023863 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 448385023864 active site 448385023865 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 448385023866 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 448385023867 dimer interface [polypeptide binding]; other site 448385023868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385023869 catalytic residue [active] 448385023870 FOG: CBS domain [General function prediction only]; Region: COG0517 448385023871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 448385023872 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 448385023873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385023874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385023875 active site 448385023876 ATP binding site [chemical binding]; other site 448385023877 substrate binding site [chemical binding]; other site 448385023878 activation loop (A-loop); other site 448385023879 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 448385023880 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 448385023881 PAS fold; Region: PAS_4; pfam08448 448385023882 PAS fold; Region: PAS_4; pfam08448 448385023883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385023884 putative active site [active] 448385023885 heme pocket [chemical binding]; other site 448385023886 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385023887 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 448385023888 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 448385023889 linker region; other site 448385023890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 448385023891 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385023892 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385023893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385023894 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385023895 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 448385023896 dimer interface [polypeptide binding]; other site 448385023897 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 448385023898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023899 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023900 active site 448385023901 phosphorylation site [posttranslational modification] 448385023902 intermolecular recognition site; other site 448385023903 dimerization interface [polypeptide binding]; other site 448385023904 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385023905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023906 ATP binding site [chemical binding]; other site 448385023907 Mg2+ binding site [ion binding]; other site 448385023908 G-X-G motif; other site 448385023909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385023910 dimerization interface [polypeptide binding]; other site 448385023911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385023912 dimer interface [polypeptide binding]; other site 448385023913 phosphorylation site [posttranslational modification] 448385023914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385023915 ATP binding site [chemical binding]; other site 448385023916 Mg2+ binding site [ion binding]; other site 448385023917 G-X-G motif; other site 448385023918 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023920 active site 448385023921 phosphorylation site [posttranslational modification] 448385023922 intermolecular recognition site; other site 448385023923 dimerization interface [polypeptide binding]; other site 448385023924 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023926 active site 448385023927 phosphorylation site [posttranslational modification] 448385023928 intermolecular recognition site; other site 448385023929 dimerization interface [polypeptide binding]; other site 448385023930 Response regulator receiver domain; Region: Response_reg; pfam00072 448385023931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385023932 active site 448385023933 phosphorylation site [posttranslational modification] 448385023934 intermolecular recognition site; other site 448385023935 dimerization interface [polypeptide binding]; other site 448385023936 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385023937 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 448385023938 active site 448385023939 methionine aminotransferase; Validated; Region: PRK09082 448385023940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385023941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385023942 homodimer interface [polypeptide binding]; other site 448385023943 catalytic residue [active] 448385023944 Nicotianamine synthase protein; Region: NAS; cl17658 448385023945 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 448385023946 active site 448385023947 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 448385023948 dimer interface [polypeptide binding]; other site 448385023949 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 448385023950 Ligand Binding Site [chemical binding]; other site 448385023951 Molecular Tunnel; other site 448385023952 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 448385023953 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 448385023954 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 448385023955 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 448385023956 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385023957 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 448385023958 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 448385023959 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 448385023960 Walker A/P-loop; other site 448385023961 ATP binding site [chemical binding]; other site 448385023962 Q-loop/lid; other site 448385023963 ABC transporter signature motif; other site 448385023964 Walker B; other site 448385023965 D-loop; other site 448385023966 H-loop/switch region; other site 448385023967 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 448385023968 classical (c) SDRs; Region: SDR_c; cd05233 448385023969 NAD(P) binding site [chemical binding]; other site 448385023970 active site 448385023971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385023972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385023973 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 448385023974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385023975 NAD(P) binding site [chemical binding]; other site 448385023976 active site 448385023977 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 448385023978 His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981 448385023979 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385023980 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 448385023981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 448385023982 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385023983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 448385023984 dimerization interface [polypeptide binding]; other site 448385023985 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385023986 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385023987 active site 448385023988 metal binding site [ion binding]; metal-binding site 448385023989 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 448385023990 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 448385023991 Ca2+ binding site [ion binding]; other site 448385023992 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 448385023993 FAD binding pocket [chemical binding]; other site 448385023994 conserved FAD binding motif [chemical binding]; other site 448385023995 phosphate binding motif [ion binding]; other site 448385023996 beta-alpha-beta structure motif; other site 448385023997 NAD binding pocket [chemical binding]; other site 448385023998 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 448385023999 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 448385024000 CoA binding domain; Region: CoA_binding_2; pfam13380 448385024001 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 448385024002 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 448385024003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385024004 PAS fold; Region: PAS_3; pfam08447 448385024005 putative active site [active] 448385024006 heme pocket [chemical binding]; other site 448385024007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 448385024008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385024009 dimer interface [polypeptide binding]; other site 448385024010 phosphorylation site [posttranslational modification] 448385024011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385024012 ATP binding site [chemical binding]; other site 448385024013 Mg2+ binding site [ion binding]; other site 448385024014 G-X-G motif; other site 448385024015 Response regulator receiver domain; Region: Response_reg; pfam00072 448385024016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385024017 active site 448385024018 phosphorylation site [posttranslational modification] 448385024019 intermolecular recognition site; other site 448385024020 dimerization interface [polypeptide binding]; other site 448385024021 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 448385024022 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 448385024023 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 448385024024 conserved cys residue [active] 448385024025 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 448385024026 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 448385024027 conserved cys residue [active] 448385024028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385024029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385024030 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 448385024031 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 448385024032 Walker A/P-loop; other site 448385024033 ATP binding site [chemical binding]; other site 448385024034 Q-loop/lid; other site 448385024035 ABC transporter signature motif; other site 448385024036 Walker B; other site 448385024037 D-loop; other site 448385024038 H-loop/switch region; other site 448385024039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 448385024040 FtsX-like permease family; Region: FtsX; pfam02687 448385024041 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 448385024042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385024043 ATP binding site [chemical binding]; other site 448385024044 Mg2+ binding site [ion binding]; other site 448385024045 G-X-G motif; other site 448385024046 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385024047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385024048 active site 448385024049 phosphorylation site [posttranslational modification] 448385024050 intermolecular recognition site; other site 448385024051 dimerization interface [polypeptide binding]; other site 448385024052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024053 Walker A motif; other site 448385024054 ATP binding site [chemical binding]; other site 448385024055 Walker B motif; other site 448385024056 arginine finger; other site 448385024057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024058 Predicted flavoprotein [General function prediction only]; Region: COG0431 448385024059 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 448385024060 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 448385024061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385024062 S-adenosylmethionine binding site [chemical binding]; other site 448385024063 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 448385024064 active site 448385024065 catalytic site [active] 448385024066 substrate binding site [chemical binding]; other site 448385024067 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385024068 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 448385024069 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 448385024070 putative hydrophobic ligand binding site [chemical binding]; other site 448385024071 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385024072 dimerization interface [polypeptide binding]; other site 448385024073 putative DNA binding site [nucleotide binding]; other site 448385024074 putative Zn2+ binding site [ion binding]; other site 448385024075 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 448385024076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385024077 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385024078 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 448385024079 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385024080 putative C-terminal domain interface [polypeptide binding]; other site 448385024081 putative GSH binding site (G-site) [chemical binding]; other site 448385024082 putative dimer interface [polypeptide binding]; other site 448385024083 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 448385024084 N-terminal domain interface [polypeptide binding]; other site 448385024085 dimer interface [polypeptide binding]; other site 448385024086 substrate binding pocket (H-site) [chemical binding]; other site 448385024087 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385024088 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385024089 active site 448385024090 catalytic tetrad [active] 448385024091 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385024092 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385024093 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385024094 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 448385024095 putative NAD(P) binding site [chemical binding]; other site 448385024096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385024097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385024098 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 448385024099 dimerization interface [polypeptide binding]; other site 448385024100 substrate binding pocket [chemical binding]; other site 448385024101 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 448385024102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385024103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385024104 homodimer interface [polypeptide binding]; other site 448385024105 catalytic residue [active] 448385024106 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 448385024107 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 448385024108 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 448385024109 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 448385024110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385024111 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385024112 putative active site [active] 448385024113 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 448385024114 Peptidase family M23; Region: Peptidase_M23; pfam01551 448385024115 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 448385024116 MgtC family; Region: MgtC; pfam02308 448385024117 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 448385024118 active site 448385024119 catalytic triad [active] 448385024120 oxyanion hole [active] 448385024121 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385024122 SIR2-like domain; Region: SIR2_2; pfam13289 448385024123 HEAT repeats; Region: HEAT_2; pfam13646 448385024124 HEAT repeats; Region: HEAT_2; pfam13646 448385024125 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385024126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385024127 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 448385024128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385024129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385024130 DNA binding residues [nucleotide binding] 448385024131 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 448385024132 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 448385024133 Predicted transcriptional regulator [Transcription]; Region: COG2378 448385024134 HTH domain; Region: HTH_11; pfam08279 448385024135 WYL domain; Region: WYL; pfam13280 448385024136 GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It...; Region: GST_N_Metaxin_like; cd03080 448385024137 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 448385024138 putative C-terminal domain interface [polypeptide binding]; other site 448385024139 putative GSH binding site [chemical binding]; other site 448385024140 putative dimer interface [polypeptide binding]; other site 448385024141 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 448385024142 putative N-terminal domain interface [polypeptide binding]; other site 448385024143 Beta propeller domain; Region: Beta_propel; pfam09826 448385024144 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 448385024145 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385024146 putative active site [active] 448385024147 Mannan-binding protein; Region: MVL; pfam12151 448385024148 Mannan-binding protein; Region: MVL; pfam12151 448385024149 Mannan-binding protein; Region: MVL; pfam12151 448385024150 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024151 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024152 phosphopeptide binding site; other site 448385024153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024154 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385024155 Walker A motif; other site 448385024156 ATP binding site [chemical binding]; other site 448385024157 Walker B motif; other site 448385024158 arginine finger; other site 448385024159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024160 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024161 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024162 active site 448385024163 ATP binding site [chemical binding]; other site 448385024164 substrate binding site [chemical binding]; other site 448385024165 activation loop (A-loop); other site 448385024166 Response regulator receiver domain; Region: Response_reg; pfam00072 448385024167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385024168 active site 448385024169 phosphorylation site [posttranslational modification] 448385024170 intermolecular recognition site; other site 448385024171 dimerization interface [polypeptide binding]; other site 448385024172 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385024173 cyclase homology domain; Region: CHD; cd07302 448385024174 nucleotidyl binding site; other site 448385024175 metal binding site [ion binding]; metal-binding site 448385024176 dimer interface [polypeptide binding]; other site 448385024177 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 448385024178 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024180 active site 448385024181 ATP binding site [chemical binding]; other site 448385024182 substrate binding site [chemical binding]; other site 448385024183 activation loop (A-loop); other site 448385024184 AAA ATPase domain; Region: AAA_16; pfam13191 448385024185 Predicted ATPase [General function prediction only]; Region: COG3899 448385024186 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385024187 GAF domain; Region: GAF; pfam01590 448385024188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385024189 dimer interface [polypeptide binding]; other site 448385024190 phosphorylation site [posttranslational modification] 448385024191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385024192 ATP binding site [chemical binding]; other site 448385024193 Mg2+ binding site [ion binding]; other site 448385024194 G-X-G motif; other site 448385024195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385024196 binding surface 448385024197 TPR motif; other site 448385024198 TPR repeat; Region: TPR_11; pfam13414 448385024199 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 448385024200 hypothetical protein; Provisional; Region: PRK08317 448385024201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385024202 S-adenosylmethionine binding site [chemical binding]; other site 448385024203 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 448385024204 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 448385024205 GDP-binding site [chemical binding]; other site 448385024206 ACT binding site; other site 448385024207 IMP binding site; other site 448385024208 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 448385024209 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 448385024210 motif 1; other site 448385024211 dimer interface [polypeptide binding]; other site 448385024212 motif 2; other site 448385024213 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 448385024214 active site 448385024215 motif 3; other site 448385024216 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 448385024217 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385024218 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385024219 phosphoglycolate phosphatase; Provisional; Region: PRK13222 448385024220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 448385024221 motif II; other site 448385024222 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 448385024223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 448385024224 non-specific DNA binding site [nucleotide binding]; other site 448385024225 salt bridge; other site 448385024226 sequence-specific DNA binding site [nucleotide binding]; other site 448385024227 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385024228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385024229 DNA binding residues [nucleotide binding] 448385024230 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 448385024231 substrate binding site [chemical binding]; other site 448385024232 active site 448385024233 Bacterial Ig-like domain; Region: Big_5; pfam13205 448385024234 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 448385024235 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 448385024236 Uncharacterized conserved protein [Function unknown]; Region: COG3391 448385024237 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385024238 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 448385024239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385024240 PAS domain; Region: PAS_9; pfam13426 448385024241 putative active site [active] 448385024242 heme pocket [chemical binding]; other site 448385024243 PAS fold; Region: PAS_4; pfam08448 448385024244 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 448385024245 putative active site [active] 448385024246 heme pocket [chemical binding]; other site 448385024247 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024248 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 448385024249 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 448385024250 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385024251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385024252 catalytic residue [active] 448385024253 Cytochrome P450; Region: p450; cl12078 448385024254 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 448385024255 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 448385024256 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 448385024257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385024258 homodimer interface [polypeptide binding]; other site 448385024259 catalytic residue [active] 448385024260 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024261 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024262 active site 448385024263 ATP binding site [chemical binding]; other site 448385024264 substrate binding site [chemical binding]; other site 448385024265 activation loop (A-loop); other site 448385024266 Predicted ATPase [General function prediction only]; Region: COG3899 448385024267 AAA ATPase domain; Region: AAA_16; pfam13191 448385024268 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 448385024269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 448385024270 active site 448385024271 AMP binding site [chemical binding]; other site 448385024272 acyl-activating enzyme (AAE) consensus motif; other site 448385024273 CoA binding site [chemical binding]; other site 448385024274 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 448385024275 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 448385024276 putative ADP-binding pocket [chemical binding]; other site 448385024277 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385024278 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385024279 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385024280 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385024281 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 448385024282 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385024283 active site 448385024284 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 448385024285 Phosphotransferase enzyme family; Region: APH; pfam01636 448385024286 putative active site [active] 448385024287 putative substrate binding site [chemical binding]; other site 448385024288 ATP binding site [chemical binding]; other site 448385024289 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 448385024290 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 448385024291 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 448385024292 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 448385024293 H-NS histone family; Region: Histone_HNS; pfam00816 448385024294 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 448385024295 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385024296 dimerization interface [polypeptide binding]; other site 448385024297 ligand binding site [chemical binding]; other site 448385024298 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024299 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 448385024300 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 448385024301 dimerization interface [polypeptide binding]; other site 448385024302 ligand binding site [chemical binding]; other site 448385024303 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024304 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 448385024305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 448385024306 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 448385024307 NAD(P) binding site [chemical binding]; other site 448385024308 active site 448385024309 B12-binding domain/radical SAM domain protein, rhizo-twelve system; Region: B12_rSAM_oligo; TIGR04295 448385024310 B12 binding domain; Region: B12-binding; pfam02310 448385024311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 448385024312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385024313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 448385024314 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 448385024315 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 448385024316 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 448385024317 NAD binding site [chemical binding]; other site 448385024318 putative substrate binding site 2 [chemical binding]; other site 448385024319 putative substrate binding site 1 [chemical binding]; other site 448385024320 active site 448385024321 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 448385024322 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 448385024323 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 448385024324 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 448385024325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 448385024326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 448385024327 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 448385024328 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 448385024329 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 448385024330 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 448385024331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 448385024332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 448385024333 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 448385024334 putative effector binding pocket; other site 448385024335 dimerization interface [polypeptide binding]; other site 448385024336 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 448385024337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 448385024338 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 448385024339 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 448385024340 dimer interface [polypeptide binding]; other site 448385024341 Mn binding site [ion binding]; other site 448385024342 K binding site [ion binding]; other site 448385024343 Cellulose binding domain; Region: CBM_2; pfam00553 448385024344 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; cl17606 448385024345 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 448385024346 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 448385024347 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385024348 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 448385024349 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 448385024350 active site 448385024351 non-prolyl cis peptide bond; other site 448385024352 hypothetical protein; Provisional; Region: PRK07236 448385024353 hypothetical protein; Provisional; Region: PRK07588 448385024354 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 448385024355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 448385024356 nucleotide binding region [chemical binding]; other site 448385024357 ATP-binding site [chemical binding]; other site 448385024358 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 448385024359 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 448385024360 NADP binding site [chemical binding]; other site 448385024361 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 448385024362 homodimer interface [polypeptide binding]; other site 448385024363 active site 448385024364 TDP-binding site; other site 448385024365 acceptor substrate-binding pocket; other site 448385024366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 448385024367 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 448385024368 PGAP1-like protein; Region: PGAP1; pfam07819 448385024369 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 448385024370 ATP binding site [chemical binding]; other site 448385024371 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 448385024372 putative dimer interface [polypeptide binding]; other site 448385024373 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 448385024374 ligand binding site [chemical binding]; other site 448385024375 Zn binding site [ion binding]; other site 448385024376 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 448385024377 PAS fold; Region: PAS_4; pfam08448 448385024378 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024379 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 448385024380 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 448385024381 active site 448385024382 catalytic triad [active] 448385024383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 448385024384 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 448385024385 active site 448385024386 catalytic tetrad [active] 448385024387 MarR family; Region: MarR_2; cl17246 448385024388 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 448385024389 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 448385024390 EamA-like transporter family; Region: EamA; pfam00892 448385024391 EamA-like transporter family; Region: EamA; pfam00892 448385024392 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 448385024393 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 448385024394 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 448385024395 active site 448385024396 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024397 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024398 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024399 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024400 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 448385024401 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024402 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024403 PA14 domain; Region: PA14; cl08459 448385024404 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385024405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 448385024406 dimerization interface [polypeptide binding]; other site 448385024407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385024408 dimer interface [polypeptide binding]; other site 448385024409 phosphorylation site [posttranslational modification] 448385024410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385024411 ATP binding site [chemical binding]; other site 448385024412 Mg2+ binding site [ion binding]; other site 448385024413 G-X-G motif; other site 448385024414 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 448385024415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 448385024416 dimer interface [polypeptide binding]; other site 448385024417 putative CheW interface [polypeptide binding]; other site 448385024418 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024419 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024420 phosphopeptide binding site; other site 448385024421 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024422 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024423 phosphopeptide binding site; other site 448385024424 ARD/ARD' family; Region: ARD; pfam03079 448385024425 Cupin domain; Region: Cupin_2; pfam07883 448385024426 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 448385024427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385024428 S-adenosylmethionine binding site [chemical binding]; other site 448385024429 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 448385024430 FAD binding site [chemical binding]; other site 448385024431 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 448385024432 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 448385024433 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 448385024434 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 448385024435 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 448385024436 dimerization interface [polypeptide binding]; other site 448385024437 putative ATP binding site [chemical binding]; other site 448385024438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 448385024439 Coenzyme A binding pocket [chemical binding]; other site 448385024440 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 448385024441 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 448385024442 FeS/SAM binding site; other site 448385024443 Predicted amidohydrolase [General function prediction only]; Region: COG0388 448385024444 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 448385024445 putative active site [active] 448385024446 catalytic triad [active] 448385024447 putative dimer interface [polypeptide binding]; other site 448385024448 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 448385024449 ribonuclease R; Region: RNase_R; TIGR02063 448385024450 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 448385024451 RNB domain; Region: RNB; pfam00773 448385024452 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 448385024453 RNA binding site [nucleotide binding]; other site 448385024454 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cl01729 448385024455 putative active site [active] 448385024456 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385024457 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 448385024458 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 448385024459 active site 448385024460 purine riboside binding site [chemical binding]; other site 448385024461 Predicted amidohydrolase [General function prediction only]; Region: COG0388 448385024462 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 448385024463 multimer interface [polypeptide binding]; other site 448385024464 active site 448385024465 catalytic triad [active] 448385024466 protein interface 1 [polypeptide binding]; other site 448385024467 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 448385024468 Ligand Binding Site [chemical binding]; other site 448385024469 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385024470 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385024471 ligand binding site [chemical binding]; other site 448385024472 flexible hinge region; other site 448385024473 Protein of unknown function (DUF721); Region: DUF721; pfam05258 448385024474 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024475 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024476 phosphopeptide binding site; other site 448385024477 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024478 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024479 phosphopeptide binding site; other site 448385024480 SCP-2 sterol transfer family; Region: SCP2; pfam02036 448385024481 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 448385024482 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 448385024483 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 448385024484 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 448385024485 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 448385024486 catalytic motif [active] 448385024487 Zn binding site [ion binding]; other site 448385024488 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024489 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024490 phosphopeptide binding site; other site 448385024491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024492 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385024493 Walker A motif; other site 448385024494 ATP binding site [chemical binding]; other site 448385024495 Walker B motif; other site 448385024496 arginine finger; other site 448385024497 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024498 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024499 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 448385024500 active site 448385024501 ATP binding site [chemical binding]; other site 448385024502 substrate binding site [chemical binding]; other site 448385024503 activation loop (A-loop); other site 448385024504 cyclase homology domain; Region: CHD; cd07302 448385024505 AAA ATPase domain; Region: AAA_16; pfam13191 448385024506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385024507 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385024508 TPR motif; other site 448385024509 binding surface 448385024510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 448385024511 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 448385024512 active site 2 [active] 448385024513 active site 1 [active] 448385024514 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 448385024515 active site 448385024516 catalytic residues [active] 448385024517 metal binding site [ion binding]; metal-binding site 448385024518 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 448385024519 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 448385024520 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 448385024521 nucleotide binding site [chemical binding]; other site 448385024522 NEF interaction site [polypeptide binding]; other site 448385024523 SBD interface [polypeptide binding]; other site 448385024524 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 448385024525 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 448385024526 peptide chain release factor 1; Validated; Region: prfA; PRK00591 448385024527 This domain is found in peptide chain release factors; Region: PCRF; smart00937 448385024528 RF-1 domain; Region: RF-1; pfam00472 448385024529 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 448385024530 nucleotide binding site/active site [active] 448385024531 HIT family signature motif; other site 448385024532 catalytic residue [active] 448385024533 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385024534 FAD binding domain; Region: FAD_binding_4; pfam01565 448385024535 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 448385024536 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385024537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385024538 S-adenosylmethionine binding site [chemical binding]; other site 448385024539 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 448385024540 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 448385024541 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385024542 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385024543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024544 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 448385024545 Walker A motif; other site 448385024546 ATP binding site [chemical binding]; other site 448385024547 Walker B motif; other site 448385024548 arginine finger; other site 448385024549 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024550 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 448385024551 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 448385024552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 448385024553 Thioredoxin; Region: Thioredoxin_4; pfam13462 448385024554 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385024555 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 448385024556 Thioredoxin; Region: Thioredoxin_4; cl17273 448385024557 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 448385024558 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 448385024559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 448385024560 active site 448385024561 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 448385024562 dimer interface [polypeptide binding]; other site 448385024563 substrate binding site [chemical binding]; other site 448385024564 metal binding sites [ion binding]; metal-binding site 448385024565 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 448385024566 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 448385024567 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 448385024568 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 448385024569 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 448385024570 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385024571 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 448385024572 Methyltransferase domain; Region: Methyltransf_31; pfam13847 448385024573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 448385024574 S-adenosylmethionine binding site [chemical binding]; other site 448385024575 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 448385024576 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 448385024577 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 448385024578 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 448385024579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385024580 ATP binding site [chemical binding]; other site 448385024581 Mg2+ binding site [ion binding]; other site 448385024582 G-X-G motif; other site 448385024583 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 448385024584 ATP binding site [chemical binding]; other site 448385024585 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 448385024586 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 448385024587 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 448385024588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385024589 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 448385024590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 448385024591 DNA binding residues [nucleotide binding] 448385024592 Predicted methyltransferases [General function prediction only]; Region: COG0313 448385024593 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 448385024594 putative SAM binding site [chemical binding]; other site 448385024595 putative homodimer interface [polypeptide binding]; other site 448385024596 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 448385024597 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 448385024598 Substrate binding site; other site 448385024599 Cupin domain; Region: Cupin_2; cl17218 448385024600 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 448385024601 NADH dehydrogenase subunit B; Provisional; Region: PRK14818 448385024602 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 448385024603 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 448385024604 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 448385024605 NADH dehydrogenase subunit D; Validated; Region: PRK06075 448385024606 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 448385024607 Interdomain contacts; other site 448385024608 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 448385024609 Right handed beta helix region; Region: Beta_helix; pfam13229 448385024610 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 448385024611 YcaO-like family; Region: YcaO; pfam02624 448385024612 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 448385024613 FMN binding site [chemical binding]; other site 448385024614 dimer interface [polypeptide binding]; other site 448385024615 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 448385024616 putative FMN binding site [chemical binding]; other site 448385024617 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 448385024618 SpaB C-terminal domain; Region: SpaB_C; cl14828 448385024619 Uncharacterized conserved protein [Function unknown]; Region: COG1944 448385024620 YcaO-like family; Region: YcaO; pfam02624 448385024621 TfuA-like protein; Region: TfuA; pfam07812 448385024622 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 448385024623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385024624 Walker A/P-loop; other site 448385024625 ATP binding site [chemical binding]; other site 448385024626 Q-loop/lid; other site 448385024627 ABC transporter signature motif; other site 448385024628 Walker B; other site 448385024629 D-loop; other site 448385024630 H-loop/switch region; other site 448385024631 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 448385024632 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 448385024633 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 448385024634 putative hydrophobic ligand binding site [chemical binding]; other site 448385024635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 448385024636 dimerization interface [polypeptide binding]; other site 448385024637 putative DNA binding site [nucleotide binding]; other site 448385024638 putative Zn2+ binding site [ion binding]; other site 448385024639 Helix-turn-helix domain; Region: HTH_18; pfam12833 448385024640 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385024641 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 448385024642 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 448385024643 catalytic residues [active] 448385024644 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 448385024645 HEAT repeats; Region: HEAT_2; pfam13646 448385024646 HEAT repeats; Region: HEAT_2; pfam13646 448385024647 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 448385024648 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 448385024649 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 448385024650 Peptidase family M28; Region: Peptidase_M28; pfam04389 448385024651 metal binding site [ion binding]; metal-binding site 448385024652 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385024653 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385024654 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 448385024655 RibD C-terminal domain; Region: RibD_C; cl17279 448385024656 Transposase; Region: HTH_Tnp_1; cl17663 448385024657 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 448385024658 DNA-binding interface [nucleotide binding]; DNA binding site 448385024659 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 448385024660 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 448385024661 Zn binding site [ion binding]; other site 448385024662 GON domain; Region: GON; pfam08685 448385024663 Family description; Region: VCBS; pfam13517 448385024664 Family description; Region: VCBS; pfam13517 448385024665 Family description; Region: VCBS; pfam13517 448385024666 Family description; Region: VCBS; pfam13517 448385024667 Family description; Region: VCBS; pfam13517 448385024668 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 448385024669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385024670 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 448385024671 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 448385024672 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 448385024673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 448385024674 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 448385024675 glutathione s-transferase; Provisional; Region: PTZ00057 448385024676 GSH binding site (G-site) [chemical binding]; other site 448385024677 C-terminal domain interface [polypeptide binding]; other site 448385024678 dimer interface [polypeptide binding]; other site 448385024679 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 448385024680 N-terminal domain interface [polypeptide binding]; other site 448385024681 dimer interface [polypeptide binding]; other site 448385024682 substrate binding pocket (H-site) [chemical binding]; other site 448385024683 PA14 domain; Region: PA14; cl08459 448385024684 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 448385024685 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 448385024686 glutamate dehydrogenase; Provisional; Region: PRK09414 448385024687 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 448385024688 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 448385024689 NAD(P) binding site [chemical binding]; other site 448385024690 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 448385024691 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 448385024692 fumarate hydratase; Reviewed; Region: fumC; PRK00485 448385024693 Class II fumarases; Region: Fumarase_classII; cd01362 448385024694 active site 448385024695 tetramer interface [polypeptide binding]; other site 448385024696 malate dehydrogenase; Provisional; Region: PRK13529 448385024697 Malic enzyme, N-terminal domain; Region: malic; pfam00390 448385024698 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 448385024699 NAD(P) binding site [chemical binding]; other site 448385024700 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 448385024701 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 448385024702 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 448385024703 [4Fe-4S] binding site [ion binding]; other site 448385024704 molybdopterin cofactor binding site; other site 448385024705 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 448385024706 molybdopterin cofactor binding site; other site 448385024707 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 448385024708 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 448385024709 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 448385024710 ligand binding site [chemical binding]; other site 448385024711 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 448385024712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385024713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385024714 RHS Repeat; Region: RHS_repeat; cl11982 448385024715 RHS Repeat; Region: RHS_repeat; pfam05593 448385024716 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 448385024717 RHS Repeat; Region: RHS_repeat; cl11982 448385024718 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 448385024719 RHS Repeat; Region: RHS_repeat; cl11982 448385024720 RHS Repeat; Region: RHS_repeat; pfam05593 448385024721 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 448385024722 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 448385024723 Fatty acid desaturase; Region: FA_desaturase; pfam00487 448385024724 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 448385024725 putative di-iron ligands [ion binding]; other site 448385024726 putative di-iron ligands [ion binding]; other site 448385024727 fumarate hydratase; Reviewed; Region: fumC; PRK00485 448385024728 Class II fumarases; Region: Fumarase_classII; cd01362 448385024729 active site 448385024730 tetramer interface [polypeptide binding]; other site 448385024731 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 448385024732 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 448385024733 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 448385024734 active site 448385024735 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024736 active site 448385024737 ATP binding site [chemical binding]; other site 448385024738 substrate binding site [chemical binding]; other site 448385024739 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024740 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385024741 substrate binding site [chemical binding]; other site 448385024742 activation loop (A-loop); other site 448385024743 activation loop (A-loop); other site 448385024744 AAA ATPase domain; Region: AAA_16; pfam13191 448385024745 Predicted ATPase [General function prediction only]; Region: COG3899 448385024746 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385024747 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 448385024748 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024749 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 448385024750 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385024751 AAA domain; Region: AAA_21; pfam13304 448385024752 Walker A/P-loop; other site 448385024753 ATP binding site [chemical binding]; other site 448385024754 putative oxidoreductase; Provisional; Region: PRK11579 448385024755 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 448385024756 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 448385024757 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 448385024758 CoA binding domain; Region: CoA_binding; smart00881 448385024759 CoA-ligase; Region: Ligase_CoA; pfam00549 448385024760 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 448385024761 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 448385024762 CoA-ligase; Region: Ligase_CoA; pfam00549 448385024763 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 448385024764 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 448385024765 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 448385024766 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 448385024767 hinge; other site 448385024768 active site 448385024769 Protein of unknown function (DUF2452); Region: DUF2452; pfam10504 448385024770 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 448385024771 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 448385024772 NAD(P) binding site [chemical binding]; other site 448385024773 Protein kinase domain; Region: Pkinase; pfam00069 448385024774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024775 active site 448385024776 ATP binding site [chemical binding]; other site 448385024777 substrate binding site [chemical binding]; other site 448385024778 activation loop (A-loop); other site 448385024779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024780 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024781 active site 448385024782 ATP binding site [chemical binding]; other site 448385024783 substrate binding site [chemical binding]; other site 448385024784 activation loop (A-loop); other site 448385024785 PEGA domain; Region: PEGA; pfam08308 448385024786 cyclase homology domain; Region: CHD; cd07302 448385024787 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 448385024788 nucleotidyl binding site; other site 448385024789 metal binding site [ion binding]; metal-binding site 448385024790 dimer interface [polypeptide binding]; other site 448385024791 cyclase homology domain; Region: CHD; cd07302 448385024792 dimer interface [polypeptide binding]; other site 448385024793 nucleotidyl binding site; other site 448385024794 metal binding site [ion binding]; metal-binding site 448385024795 AAA ATPase domain; Region: AAA_16; pfam13191 448385024796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385024797 binding surface 448385024798 TPR motif; other site 448385024799 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 448385024800 Sulfate transporter family; Region: Sulfate_transp; pfam00916 448385024801 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 448385024802 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 448385024803 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 448385024804 ligand binding site [chemical binding]; other site 448385024805 flexible hinge region; other site 448385024806 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 448385024807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 448385024808 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 448385024809 agmatinase; Region: agmatinase; TIGR01230 448385024810 oligomer interface [polypeptide binding]; other site 448385024811 putative active site [active] 448385024812 Mn binding site [ion binding]; other site 448385024813 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 448385024814 Predicted amidohydrolase [General function prediction only]; Region: COG0388 448385024815 active site 448385024816 catalytic triad [active] 448385024817 dimer interface [polypeptide binding]; other site 448385024818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 448385024819 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 448385024820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 448385024821 TPR repeat; Region: TPR_11; pfam13414 448385024822 binding surface 448385024823 TPR motif; other site 448385024824 PEGA domain; Region: PEGA; pfam08308 448385024825 PEGA domain; Region: PEGA; pfam08308 448385024826 PEGA domain; Region: PEGA; pfam08308 448385024827 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 448385024828 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 448385024829 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385024830 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 448385024831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385024832 dimer interface [polypeptide binding]; other site 448385024833 conserved gate region; other site 448385024834 putative PBP binding loops; other site 448385024835 ABC-ATPase subunit interface; other site 448385024836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385024837 dimer interface [polypeptide binding]; other site 448385024838 conserved gate region; other site 448385024839 putative PBP binding loops; other site 448385024840 ABC-ATPase subunit interface; other site 448385024841 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 448385024842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385024843 Walker A/P-loop; other site 448385024844 ATP binding site [chemical binding]; other site 448385024845 Q-loop/lid; other site 448385024846 ABC transporter signature motif; other site 448385024847 Walker B; other site 448385024848 D-loop; other site 448385024849 H-loop/switch region; other site 448385024850 TOBE domain; Region: TOBE_2; pfam08402 448385024851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024852 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385024853 active site 448385024854 ATP binding site [chemical binding]; other site 448385024855 substrate binding site [chemical binding]; other site 448385024856 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385024857 substrate binding site [chemical binding]; other site 448385024858 activation loop (A-loop); other site 448385024859 activation loop (A-loop); other site 448385024860 AAA ATPase domain; Region: AAA_16; pfam13191 448385024861 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 448385024862 MG2 domain; Region: A2M_N; pfam01835 448385024863 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 448385024864 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385024865 catalytic residue [active] 448385024866 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 448385024867 Family description; Region: VCBS; pfam13517 448385024868 Family description; Region: VCBS; pfam13517 448385024869 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 448385024870 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385024871 inhibitor-cofactor binding pocket; inhibition site 448385024872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385024873 catalytic residue [active] 448385024874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024876 active site 448385024877 ATP binding site [chemical binding]; other site 448385024878 substrate binding site [chemical binding]; other site 448385024879 activation loop (A-loop); other site 448385024880 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 448385024881 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 448385024882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 448385024883 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl11892 448385024884 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cl11893 448385024885 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 448385024886 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 448385024887 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 448385024888 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 448385024889 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 448385024890 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 448385024891 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 448385024892 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 448385024893 NAD(P) binding site [chemical binding]; other site 448385024894 catalytic residues [active] 448385024895 4-aminobutyrate aminotransferase, eukaryotic type; Region: GABAtrns_euk; TIGR00699 448385024896 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 448385024897 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 448385024898 catalytic residue [active] 448385024899 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 448385024900 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 448385024901 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 448385024902 putative molybdopterin cofactor binding site [chemical binding]; other site 448385024903 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 448385024904 putative molybdopterin cofactor binding site; other site 448385024905 4-aminobutyrate aminotransferase, eukaryotic type; Region: GABAtrns_euk; TIGR00699 448385024906 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 448385024907 inhibitor-cofactor binding pocket; inhibition site 448385024908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385024909 catalytic residue [active] 448385024910 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 448385024911 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 448385024912 putative active site [active] 448385024913 Zn binding site [ion binding]; other site 448385024914 Pathogenicity factor; Region: AvrE; pfam11725 448385024915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024917 active site 448385024918 ATP binding site [chemical binding]; other site 448385024919 substrate binding site [chemical binding]; other site 448385024920 activation loop (A-loop); other site 448385024921 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385024922 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385024923 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385024924 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 448385024925 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 448385024926 phosphopeptide binding site; other site 448385024927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024928 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 448385024929 Walker A motif; other site 448385024930 ATP binding site [chemical binding]; other site 448385024931 Walker B motif; other site 448385024932 arginine finger; other site 448385024933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024934 GAF domain; Region: GAF; pfam01590 448385024935 GAF domain; Region: GAF_2; pfam13185 448385024936 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 448385024937 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 448385024938 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385024939 Double zinc ribbon; Region: DZR; pfam12773 448385024940 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385024941 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385024942 active site 448385024943 ATP binding site [chemical binding]; other site 448385024944 substrate binding site [chemical binding]; other site 448385024945 activation loop (A-loop); other site 448385024946 threonine synthase; Region: PLN02569 448385024947 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 448385024948 homodimer interface [polypeptide binding]; other site 448385024949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 448385024950 catalytic residue [active] 448385024951 Response regulator receiver domain; Region: Response_reg; pfam00072 448385024952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385024953 active site 448385024954 phosphorylation site [posttranslational modification] 448385024955 intermolecular recognition site; other site 448385024956 dimerization interface [polypeptide binding]; other site 448385024957 PAS fold; Region: PAS_4; pfam08448 448385024958 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 448385024959 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 448385024960 Competence protein A; Region: Competence_A; pfam11104 448385024961 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 448385024962 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 448385024963 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 448385024964 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 448385024965 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 448385024966 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 448385024967 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 448385024968 type II secretion system protein F; Region: GspF; TIGR02120 448385024969 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 448385024970 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 448385024971 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 448385024972 type II secretion system protein E; Region: type_II_gspE; TIGR02533 448385024973 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 448385024974 Walker A motif; other site 448385024975 ATP binding site [chemical binding]; other site 448385024976 Walker B motif; other site 448385024977 type II secretion system protein D; Region: type_II_gspD; TIGR02517 448385024978 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 448385024979 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 448385024980 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 448385024981 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 448385024982 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 448385024983 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 448385024984 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 448385024985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 448385024986 active site 448385024987 phosphorylation site [posttranslational modification] 448385024988 intermolecular recognition site; other site 448385024989 dimerization interface [polypeptide binding]; other site 448385024990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 448385024991 Walker A motif; other site 448385024992 ATP binding site [chemical binding]; other site 448385024993 Walker B motif; other site 448385024994 arginine finger; other site 448385024995 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 448385024996 Isochorismatase family; Region: Isochorismatase; pfam00857 448385024997 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 448385024998 catalytic triad [active] 448385024999 dimer interface [polypeptide binding]; other site 448385025000 conserved cis-peptide bond; other site 448385025001 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 448385025002 dimer interface [polypeptide binding]; other site 448385025003 [2Fe-2S] cluster binding site [ion binding]; other site 448385025004 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 448385025005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 448385025006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 448385025007 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 448385025008 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 448385025009 active site 448385025010 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 448385025011 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 448385025012 heat shock protein 90; Provisional; Region: PRK05218 448385025013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385025014 ATP binding site [chemical binding]; other site 448385025015 Mg2+ binding site [ion binding]; other site 448385025016 G-X-G motif; other site 448385025017 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 448385025018 Tetratricopeptide repeat; Region: TPR_6; pfam13174 448385025019 elongation factor P; Validated; Region: PRK00529 448385025020 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 448385025021 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 448385025022 RNA binding site [nucleotide binding]; other site 448385025023 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 448385025024 RNA binding site [nucleotide binding]; other site 448385025025 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 448385025026 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 448385025027 Chromate transporter; Region: Chromate_transp; pfam02417 448385025028 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 448385025029 ligand binding site; other site 448385025030 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 448385025031 isovaleryl-CoA dehydrogenase; Provisional; Region: PTZ00461 448385025032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 448385025033 active site 448385025034 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 448385025035 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 448385025036 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385025037 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385025038 CcmE; Region: CcmE; cl00994 448385025039 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 448385025040 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 448385025041 putative active site [active] 448385025042 catalytic site [active] 448385025043 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 448385025044 putative catalytic site [active] 448385025045 putative metal binding site [ion binding]; other site 448385025046 putative phosphate binding site [ion binding]; other site 448385025047 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 448385025048 NADH(P)-binding; Region: NAD_binding_10; pfam13460 448385025049 NAD binding site [chemical binding]; other site 448385025050 substrate binding site [chemical binding]; other site 448385025051 putative active site [active] 448385025052 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385025053 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385025054 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 448385025055 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385025056 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385025057 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385025058 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385025059 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 448385025060 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 448385025061 Flagellin N-methylase; Region: FliB; cl00497 448385025062 Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527 448385025063 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 448385025064 nucleotide binding site [chemical binding]; other site 448385025065 substrate binding site [chemical binding]; other site 448385025066 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912 448385025067 dimer interface [polypeptide binding]; other site 448385025068 allosteric regulatory binding pocket; other site 448385025069 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 448385025070 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 448385025071 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 448385025072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 448385025073 Walker A/P-loop; other site 448385025074 ATP binding site [chemical binding]; other site 448385025075 Q-loop/lid; other site 448385025076 ABC transporter signature motif; other site 448385025077 Walker B; other site 448385025078 D-loop; other site 448385025079 H-loop/switch region; other site 448385025080 TOBE domain; Region: TOBE_2; pfam08402 448385025081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 448385025082 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 448385025083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385025084 dimer interface [polypeptide binding]; other site 448385025085 conserved gate region; other site 448385025086 putative PBP binding loops; other site 448385025087 ABC-ATPase subunit interface; other site 448385025088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 448385025089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385025090 dimer interface [polypeptide binding]; other site 448385025091 conserved gate region; other site 448385025092 putative PBP binding loops; other site 448385025093 ABC-ATPase subunit interface; other site 448385025094 PEGA domain; Region: PEGA; pfam08308 448385025095 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385025096 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 448385025097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 448385025098 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 448385025099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 448385025100 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 448385025101 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 448385025102 putative active site [active] 448385025103 putative NTP binding site [chemical binding]; other site 448385025104 putative nucleic acid binding site [nucleotide binding]; other site 448385025105 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 448385025106 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 448385025107 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 448385025108 Mechanosensitive ion channel; Region: MS_channel; pfam00924 448385025109 Uncharacterized conserved protein [Function unknown]; Region: COG1262 448385025110 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 448385025111 PAS fold; Region: PAS_4; pfam08448 448385025112 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 448385025113 putative active site [active] 448385025114 heme pocket [chemical binding]; other site 448385025115 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 448385025116 GAF domain; Region: GAF; pfam01590 448385025117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 448385025118 dimer interface [polypeptide binding]; other site 448385025119 phosphorylation site [posttranslational modification] 448385025120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 448385025121 ATP binding site [chemical binding]; other site 448385025122 Mg2+ binding site [ion binding]; other site 448385025123 G-X-G motif; other site 448385025124 putative lipid kinase; Reviewed; Region: PRK13057 448385025125 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 448385025126 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 448385025127 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 448385025128 active site 448385025129 metal binding site [ion binding]; metal-binding site 448385025130 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 448385025131 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 448385025132 active site 448385025133 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 448385025134 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 448385025135 N- and C-terminal domain interface [polypeptide binding]; other site 448385025136 D-xylulose kinase; Region: XylB; TIGR01312 448385025137 active site 448385025138 MgATP binding site [chemical binding]; other site 448385025139 catalytic site [active] 448385025140 metal binding site [ion binding]; metal-binding site 448385025141 xylulose binding site [chemical binding]; other site 448385025142 homodimer interface [polypeptide binding]; other site 448385025143 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 448385025144 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 448385025145 putative NAD(P) binding site [chemical binding]; other site 448385025146 catalytic Zn binding site [ion binding]; other site 448385025147 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 448385025148 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 448385025149 classical (c) SDRs; Region: SDR_c; cd05233 448385025150 NAD(P) binding site [chemical binding]; other site 448385025151 active site 448385025152 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 448385025153 active site 448385025154 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 448385025155 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 448385025156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385025157 dimer interface [polypeptide binding]; other site 448385025158 conserved gate region; other site 448385025159 putative PBP binding loops; other site 448385025160 ABC-ATPase subunit interface; other site 448385025161 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 448385025162 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 448385025163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 448385025164 dimer interface [polypeptide binding]; other site 448385025165 conserved gate region; other site 448385025166 putative PBP binding loops; other site 448385025167 ABC-ATPase subunit interface; other site 448385025168 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 448385025169 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 448385025170 Walker A/P-loop; other site 448385025171 ATP binding site [chemical binding]; other site 448385025172 Q-loop/lid; other site 448385025173 ABC transporter signature motif; other site 448385025174 Walker B; other site 448385025175 D-loop; other site 448385025176 H-loop/switch region; other site 448385025177 TOBE domain; Region: TOBE_2; pfam08402 448385025178 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 448385025179 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385025180 putative active site [active] 448385025181 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 448385025182 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 448385025183 dimer interface [polypeptide binding]; other site 448385025184 putative functional site; other site 448385025185 putative MPT binding site; other site 448385025186 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 448385025187 Domain of unknown function (DUF303); Region: DUF303; pfam03629 448385025188 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 448385025189 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 448385025190 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 448385025191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 448385025192 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 448385025193 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 448385025194 metal ion-dependent adhesion site (MIDAS); other site 448385025195 Integrase core domain; Region: rve; pfam00665 448385025196 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 448385025197 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 448385025198 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 448385025199 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 448385025200 putative NAD(P) binding site [chemical binding]; other site 448385025201 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 448385025202 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 448385025203 putative active site [active] 448385025204 putative metal binding site [ion binding]; other site 448385025205 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 448385025206 FAD binding domain; Region: FAD_binding_4; pfam01565 448385025207 Transcriptional regulators [Transcription]; Region: MarR; COG1846 448385025208 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 448385025209 Protein of unknown function (DUF664); Region: DUF664; pfam04978 448385025210 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 448385025211 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 448385025212 GTP binding site; other site 448385025213 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 448385025214 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 448385025215 Double zinc ribbon; Region: DZR; pfam12773 448385025216 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 448385025217 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385025218 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385025219 active site 448385025220 ATP binding site [chemical binding]; other site 448385025221 substrate binding site [chemical binding]; other site 448385025222 activation loop (A-loop); other site 448385025223 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385025224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385025225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 448385025226 active site 448385025227 ATP binding site [chemical binding]; other site 448385025228 substrate binding site [chemical binding]; other site 448385025229 activation loop (A-loop); other site 448385025230 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 448385025231 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 448385025232 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 448385025233 conserved hypothetical protein; Region: TIGR02270 448385025234 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 448385025235 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 448385025236 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 448385025237 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 448385025238 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 448385025239 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 448385025240 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 448385025241 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 448385025242 Protein of unknown function (DUF796); Region: DUF796; pfam05638 448385025243 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 448385025244 Protein of unknown function (DUF877); Region: DUF877; pfam05943 448385025245 Protein of unknown function (DUF770); Region: DUF770; pfam05591 448385025246 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 448385025247 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 448385025248 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 448385025249 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 448385025250 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 448385025251 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 448385025252 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 448385025253 Disintegrin; Region: Disintegrin; cl10507 448385025254 Disintegrin; Region: Disintegrin; cl10507 448385025255 Disintegrin; Region: Disintegrin; cl10507 448385025256 Disintegrin; Region: Disintegrin; cl10507 448385025257 Disintegrin; Region: Disintegrin; cl10507 448385025258 Disintegrin; Region: Disintegrin; cl10507 448385025259 Disintegrin; Region: Disintegrin; cl10507 448385025260 Disintegrin; Region: Disintegrin; cl10507 448385025261 Disintegrin; Region: Disintegrin; cl10507 448385025262 Disintegrin; Region: Disintegrin; cl10507 448385025263 Disintegrin; Region: Disintegrin; cl10507 448385025264 Disintegrin; Region: Disintegrin; cl10507 448385025265 Disintegrin; Region: Disintegrin; cl10507 448385025266 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 448385025267 putative active site [active] 448385025268 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 448385025269 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 448385025270 active site 448385025271 ATP binding site [chemical binding]; other site 448385025272 substrate binding site [chemical binding]; other site 448385025273 activation loop (A-loop); other site 448385025274 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 448385025275 tetratricopeptide repeat protein; Provisional; Region: PRK11788 448385025276 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 448385025277 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 448385025278 DNA methylase; Region: N6_N4_Mtase; pfam01555 448385025279 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 448385025280 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 448385025281 core domain interface [polypeptide binding]; other site 448385025282 delta subunit interface [polypeptide binding]; other site 448385025283 epsilon subunit interface [polypeptide binding]; other site 448385025284 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 448385025285 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385025286 Walker A motif; other site 448385025287 ATP binding site [chemical binding]; other site 448385025288 Walker B motif; other site 448385025289 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 448385025290 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 448385025291 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 448385025292 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 448385025293 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 448385025294 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 448385025295 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 448385025296 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 448385025297 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 448385025298 active site 448385025299 dinuclear metal binding site [ion binding]; other site 448385025300 dimerization interface [polypeptide binding]; other site 448385025301 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479