-- dump date   	20140620_071618
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
743722000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
743722000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
743722000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722000004	Walker A motif; other site
743722000005	ATP binding site [chemical binding]; other site
743722000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
743722000007	Walker B motif; other site
743722000008	arginine finger; other site
743722000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
743722000010	DnaA box-binding interface [nucleotide binding]; other site
743722000011	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
743722000012	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
743722000013	putative dimer interface [polypeptide binding]; other site
743722000014	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743722000015	active site
743722000016	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
743722000017	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
743722000018	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
743722000019	NAD binding site [chemical binding]; other site
743722000020	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
743722000021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722000022	S-adenosylmethionine binding site [chemical binding]; other site
743722000023	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
743722000024	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
743722000025	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
743722000026	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
743722000027	putative phosphate acyltransferase; Provisional; Region: PRK05331
743722000028	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
743722000029	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743722000030	dimer interface [polypeptide binding]; other site
743722000031	active site
743722000032	CoA binding pocket [chemical binding]; other site
743722000033	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
743722000034	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
743722000035	carboxyltransferase (CT) interaction site; other site
743722000036	biotinylation site [posttranslational modification]; other site
743722000037	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
743722000038	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743722000039	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
743722000040	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
743722000041	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
743722000042	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
743722000043	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722000044	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
743722000045	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
743722000046	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722000047	metal binding site [ion binding]; metal-binding site
743722000048	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
743722000049	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
743722000050	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
743722000051	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
743722000052	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
743722000053	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743722000054	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743722000055	active site
743722000056	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
743722000057	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
743722000058	dimer interface [polypeptide binding]; other site
743722000059	active site
743722000060	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
743722000061	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
743722000062	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
743722000063	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743722000064	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
743722000065	substrate binding site [chemical binding]; other site
743722000066	oxyanion hole (OAH) forming residues; other site
743722000067	trimer interface [polypeptide binding]; other site
743722000068	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722000069	MarR family; Region: MarR_2; pfam12802
743722000070	Cupin-like domain; Region: Cupin_8; pfam13621
743722000071	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
743722000072	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
743722000073	acyl-activating enzyme (AAE) consensus motif; other site
743722000074	putative AMP binding site [chemical binding]; other site
743722000075	putative active site [active]
743722000076	putative CoA binding site [chemical binding]; other site
743722000077	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
743722000078	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
743722000079	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
743722000080	protein binding site [polypeptide binding]; other site
743722000081	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722000082	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722000083	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722000084	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722000085	Protein export membrane protein; Region: SecD_SecF; cl14618
743722000086	Outer membrane efflux protein; Region: OEP; pfam02321
743722000087	Outer membrane efflux protein; Region: OEP; pfam02321
743722000088	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
743722000089	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
743722000090	catalytic residues [active]
743722000091	dimer interface [polypeptide binding]; other site
743722000092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743722000093	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743722000094	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
743722000095	phosphodiesterase; Provisional; Region: PRK12704
743722000096	Protein of unknown function DUF72; Region: DUF72; pfam01904
743722000097	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
743722000098	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722000099	metal binding site [ion binding]; metal-binding site
743722000100	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
743722000101	Recombination protein O N terminal; Region: RecO_N; pfam11967
743722000102	Recombination protein O C terminal; Region: RecO_C; pfam02565
743722000103	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
743722000104	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
743722000105	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722000106	active site
743722000107	HIGH motif; other site
743722000108	nucleotide binding site [chemical binding]; other site
743722000109	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722000110	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722000111	active site
743722000112	KMSKS motif; other site
743722000113	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
743722000114	tRNA binding surface [nucleotide binding]; other site
743722000115	anticodon binding site; other site
743722000116	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
743722000117	lipoprotein signal peptidase; Provisional; Region: PRK14788
743722000118	lipoprotein signal peptidase; Provisional; Region: PRK14787
743722000119	Uncharacterized conserved protein [Function unknown]; Region: COG2968
743722000120	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
743722000121	aconitate hydratase; Validated; Region: PRK09277
743722000122	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
743722000123	substrate binding site [chemical binding]; other site
743722000124	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
743722000125	ligand binding site [chemical binding]; other site
743722000126	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
743722000127	substrate binding site [chemical binding]; other site
743722000128	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
743722000129	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
743722000130	nucleotide binding pocket [chemical binding]; other site
743722000131	K-X-D-G motif; other site
743722000132	catalytic site [active]
743722000133	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
743722000134	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
743722000135	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
743722000136	Dimer interface [polypeptide binding]; other site
743722000137	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
743722000138	dihydrodipicolinate synthase; Region: dapA; TIGR00674
743722000139	dimer interface [polypeptide binding]; other site
743722000140	active site
743722000141	catalytic residue [active]
743722000142	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
743722000143	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743722000144	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722000145	catalytic residue [active]
743722000146	cell division protein FtsZ; Validated; Region: PRK09330
743722000147	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
743722000148	nucleotide binding site [chemical binding]; other site
743722000149	SulA interaction site; other site
743722000150	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
743722000151	Cell division protein FtsA; Region: FtsA; smart00842
743722000152	Cell division protein FtsA; Region: FtsA; pfam14450
743722000153	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
743722000154	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
743722000155	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743722000156	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722000157	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743722000158	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
743722000159	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
743722000160	active site
743722000161	homodimer interface [polypeptide binding]; other site
743722000162	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
743722000163	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
743722000164	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722000165	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743722000166	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
743722000167	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
743722000168	Mg++ binding site [ion binding]; other site
743722000169	putative catalytic motif [active]
743722000170	putative substrate binding site [chemical binding]; other site
743722000171	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
743722000172	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743722000173	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722000174	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743722000175	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
743722000176	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
743722000177	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
743722000178	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
743722000179	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
743722000180	MraW methylase family; Region: Methyltransf_5; cl17771
743722000181	cell division protein MraZ; Reviewed; Region: PRK00326
743722000182	MraZ protein; Region: MraZ; pfam02381
743722000183	MraZ protein; Region: MraZ; pfam02381
743722000184	BON domain; Region: BON; pfam04972
743722000185	Phosphoglycerate kinase; Region: PGK; pfam00162
743722000186	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
743722000187	substrate binding site [chemical binding]; other site
743722000188	hinge regions; other site
743722000189	ADP binding site [chemical binding]; other site
743722000190	catalytic site [active]
743722000191	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
743722000192	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
743722000193	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
743722000194	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722000195	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
743722000196	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722000197	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000198	short chain dehydrogenase; Provisional; Region: PRK12744
743722000199	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
743722000200	NADP binding site [chemical binding]; other site
743722000201	homodimer interface [polypeptide binding]; other site
743722000202	active site
743722000203	substrate binding site [chemical binding]; other site
743722000204	adenylate kinase; Reviewed; Region: adk; PRK00279
743722000205	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
743722000206	AMP-binding site [chemical binding]; other site
743722000207	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
743722000208	GTPase CgtA; Reviewed; Region: obgE; PRK12299
743722000209	GTP1/OBG; Region: GTP1_OBG; pfam01018
743722000210	Obg GTPase; Region: Obg; cd01898
743722000211	G1 box; other site
743722000212	GTP/Mg2+ binding site [chemical binding]; other site
743722000213	Switch I region; other site
743722000214	G2 box; other site
743722000215	G3 box; other site
743722000216	Switch II region; other site
743722000217	G4 box; other site
743722000218	G5 box; other site
743722000219	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
743722000220	dimer interface [polypeptide binding]; other site
743722000221	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722000222	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
743722000223	catalytic motif [active]
743722000224	Catalytic residue [active]
743722000225	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
743722000226	inhibitor binding site; inhibition site
743722000227	catalytic motif [active]
743722000228	Catalytic residue [active]
743722000229	Active site flap [active]
743722000230	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
743722000231	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722000232	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
743722000233	Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978
743722000234	AAA domain; Region: AAA_21; pfam13304
743722000235	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722000236	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722000237	catalytic residues [active]
743722000238	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000239	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000240	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000241	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722000242	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722000243	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722000244	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722000245	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722000246	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722000247	DNA binding residues [nucleotide binding]
743722000248	FecR protein; Region: FecR; pfam04773
743722000249	Helix-turn-helix domain; Region: HTH_17; pfam12728
743722000250	Domain of unknown function (DUF305); Region: DUF305; cl17794
743722000251	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722000252	metal-binding site [ion binding]
743722000253	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743722000254	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722000255	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722000256	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722000257	putative catalytic site [active]
743722000258	putative metal binding site [ion binding]; other site
743722000259	putative phosphate binding site [ion binding]; other site
743722000260	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722000261	SusD family; Region: SusD; pfam07980
743722000262	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000263	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000264	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000265	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
743722000266	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722000267	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
743722000268	dimerization interface [polypeptide binding]; other site
743722000269	putative active cleft [active]
743722000270	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
743722000271	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722000272	putative substrate translocation pore; other site
743722000273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722000274	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
743722000275	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743722000276	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722000277	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743722000278	nucleotide binding site [chemical binding]; other site
743722000279	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722000280	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
743722000281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743722000282	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743722000283	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
743722000284	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
743722000285	catalytic residues [active]
743722000286	catalytic nucleophile [active]
743722000287	Recombinase; Region: Recombinase; pfam07508
743722000288	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
743722000289	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
743722000290	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
743722000291	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
743722000292	Carboxylesterase family; Region: COesterase; pfam00135
743722000293	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743722000294	substrate binding pocket [chemical binding]; other site
743722000295	catalytic triad [active]
743722000296	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722000297	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743722000298	NAD(P) binding site [chemical binding]; other site
743722000299	active site
743722000300	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722000301	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
743722000302	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722000303	catalytic site [active]
743722000304	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722000305	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722000306	active site
743722000307	catalytic tetrad [active]
743722000308	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722000309	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722000310	active site
743722000311	catalytic tetrad [active]
743722000312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722000313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000314	Histidine kinase; Region: His_kinase; pfam06580
743722000315	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722000316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722000317	active site
743722000318	phosphorylation site [posttranslational modification]
743722000319	intermolecular recognition site; other site
743722000320	dimerization interface [polypeptide binding]; other site
743722000321	LytTr DNA-binding domain; Region: LytTR; smart00850
743722000322	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722000323	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000324	SnoaL-like domain; Region: SnoaL_3; pfam13474
743722000325	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
743722000326	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
743722000327	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722000328	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722000329	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
743722000330	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722000331	catalytic loop [active]
743722000332	iron binding site [ion binding]; other site
743722000333	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
743722000334	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
743722000335	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
743722000336	XdhC Rossmann domain; Region: XdhC_C; pfam13478
743722000337	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
743722000338	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722000339	FeS/SAM binding site; other site
743722000340	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
743722000341	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
743722000342	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722000343	N-terminal plug; other site
743722000344	ligand-binding site [chemical binding]; other site
743722000345	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743722000346	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
743722000347	MoaE homodimer interface [polypeptide binding]; other site
743722000348	MoaD interaction [polypeptide binding]; other site
743722000349	active site residues [active]
743722000350	Predicted membrane protein [Function unknown]; Region: COG2311
743722000351	Protein of unknown function (DUF418); Region: DUF418; cl12135
743722000352	Protein of unknown function (DUF418); Region: DUF418; pfam04235
743722000353	FecR protein; Region: FecR; pfam04773
743722000354	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722000355	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722000356	DNA binding residues [nucleotide binding]
743722000357	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722000358	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000359	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000360	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000361	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722000362	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722000363	catalytic residues [active]
743722000364	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
743722000365	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000366	non-specific DNA binding site [nucleotide binding]; other site
743722000367	salt bridge; other site
743722000368	sequence-specific DNA binding site [nucleotide binding]; other site
743722000369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000370	non-specific DNA binding site [nucleotide binding]; other site
743722000371	salt bridge; other site
743722000372	sequence-specific DNA binding site [nucleotide binding]; other site
743722000373	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743722000374	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000375	non-specific DNA binding site [nucleotide binding]; other site
743722000376	salt bridge; other site
743722000377	sequence-specific DNA binding site [nucleotide binding]; other site
743722000378	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
743722000379	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
743722000380	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722000381	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
743722000382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
743722000383	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
743722000384	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
743722000385	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
743722000386	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
743722000387	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722000388	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
743722000389	hypothetical protein; Provisional; Region: PRK07758
743722000390	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722000391	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743722000392	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722000393	phosphodiesterase YaeI; Provisional; Region: PRK11340
743722000394	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
743722000395	putative active site [active]
743722000396	putative metal binding site [ion binding]; other site
743722000397	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722000398	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722000399	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
743722000400	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
743722000401	putative Cl- selectivity filter; other site
743722000402	putative pore gating glutamate residue; other site
743722000403	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
743722000404	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
743722000405	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722000406	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722000407	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
743722000408	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722000409	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722000410	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722000411	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722000412	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000413	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
743722000414	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722000415	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722000416	ligand binding site [chemical binding]; other site
743722000417	flexible hinge region; other site
743722000418	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
743722000419	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
743722000420	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
743722000421	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
743722000422	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743722000423	NAD binding site [chemical binding]; other site
743722000424	substrate binding site [chemical binding]; other site
743722000425	putative active site [active]
743722000426	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
743722000427	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
743722000428	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
743722000429	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722000430	SusD family; Region: SusD; pfam07980
743722000431	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000432	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722000433	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722000434	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722000435	FecR protein; Region: FecR; pfam04773
743722000436	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722000437	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722000438	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722000439	DNA binding residues [nucleotide binding]
743722000440	putative transporter; Provisional; Region: PRK10484
743722000441	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
743722000442	Na binding site [ion binding]; other site
743722000443	substrate binding site [chemical binding]; other site
743722000444	Family of unknown function (DUF706); Region: DUF706; pfam05153
743722000445	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722000446	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722000447	DNA binding site [nucleotide binding]
743722000448	domain linker motif; other site
743722000449	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722000450	dimerization interface [polypeptide binding]; other site
743722000451	ligand binding site [chemical binding]; other site
743722000452	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
743722000453	Predicted flavoprotein [General function prediction only]; Region: COG0431
743722000454	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722000455	Carboxylesterase family; Region: COesterase; pfam00135
743722000456	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743722000457	substrate binding pocket [chemical binding]; other site
743722000458	catalytic triad [active]
743722000459	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722000460	PAS fold; Region: PAS_3; pfam08447
743722000461	putative active site [active]
743722000462	heme pocket [chemical binding]; other site
743722000463	PAS fold; Region: PAS_4; pfam08448
743722000464	PAS domain S-box; Region: sensory_box; TIGR00229
743722000465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722000466	putative active site [active]
743722000467	heme pocket [chemical binding]; other site
743722000468	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722000469	dimer interface [polypeptide binding]; other site
743722000470	phosphorylation site [posttranslational modification]
743722000471	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722000472	ATP binding site [chemical binding]; other site
743722000473	Mg2+ binding site [ion binding]; other site
743722000474	G-X-G motif; other site
743722000475	Response regulator receiver domain; Region: Response_reg; pfam00072
743722000476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722000477	active site
743722000478	phosphorylation site [posttranslational modification]
743722000479	intermolecular recognition site; other site
743722000480	dimerization interface [polypeptide binding]; other site
743722000481	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
743722000482	putative binding surface; other site
743722000483	active site
743722000484	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
743722000485	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
743722000486	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722000487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722000488	putative substrate translocation pore; other site
743722000489	metal-dependent hydrolase; Provisional; Region: PRK13291
743722000490	DinB superfamily; Region: DinB_2; pfam12867
743722000491	Uncharacterized conserved protein [Function unknown]; Region: COG0432
743722000492	Right handed beta helix region; Region: Beta_helix; pfam13229
743722000493	Right handed beta helix region; Region: Beta_helix; pfam13229
743722000494	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
743722000495	heme-binding residues [chemical binding]; other site
743722000496	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
743722000497	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722000498	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722000499	DinB superfamily; Region: DinB_2; pfam12867
743722000500	Protein of unknown function (DUF664); Region: DUF664; pfam04978
743722000501	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
743722000502	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
743722000503	conserved cys residue [active]
743722000504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722000505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000506	Variant SH3 domain; Region: SH3_2; pfam07653
743722000507	peptide ligand binding site [polypeptide binding]; other site
743722000508	Src Homology 3 domain superfamily; Region: SH3; cl17036
743722000509	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743722000510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000511	non-specific DNA binding site [nucleotide binding]; other site
743722000512	salt bridge; other site
743722000513	sequence-specific DNA binding site [nucleotide binding]; other site
743722000514	Cupin domain; Region: Cupin_2; pfam07883
743722000515	Protein of unknown function (DUF808); Region: DUF808; cl01002
743722000516	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722000517	dimerization interface [polypeptide binding]; other site
743722000518	putative DNA binding site [nucleotide binding]; other site
743722000519	putative Zn2+ binding site [ion binding]; other site
743722000520	MerT mercuric transport protein; Region: MerT; cl03578
743722000521	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722000522	metal-binding site [ion binding]
743722000523	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000524	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722000525	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722000526	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
743722000527	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
743722000528	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722000529	Outer membrane efflux protein; Region: OEP; pfam02321
743722000530	Outer membrane efflux protein; Region: OEP; pfam02321
743722000531	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
743722000532	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722000533	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
743722000534	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722000535	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
743722000536	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
743722000537	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722000538	active site
743722000539	metal binding site [ion binding]; metal-binding site
743722000540	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
743722000541	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722000542	active site
743722000543	metal binding site [ion binding]; metal-binding site
743722000544	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
743722000545	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
743722000546	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
743722000547	arsenical-resistance protein; Region: acr3; TIGR00832
743722000548	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743722000549	Low molecular weight phosphatase family; Region: LMWPc; cd00115
743722000550	active site
743722000551	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
743722000552	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722000553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722000554	Coenzyme A binding pocket [chemical binding]; other site
743722000555	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722000556	dimerization interface [polypeptide binding]; other site
743722000557	putative DNA binding site [nucleotide binding]; other site
743722000558	putative Zn2+ binding site [ion binding]; other site
743722000559	Domain of unknown function (DUF932); Region: DUF932; cl12129
743722000560	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
743722000561	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
743722000562	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
743722000563	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
743722000564	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
743722000565	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
743722000566	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
743722000567	AAA ATPase domain; Region: AAA_16; pfam13191
743722000568	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
743722000569	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
743722000570	RteC protein; Region: RteC; pfam09357
743722000571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000572	non-specific DNA binding site [nucleotide binding]; other site
743722000573	salt bridge; other site
743722000574	sequence-specific DNA binding site [nucleotide binding]; other site
743722000575	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722000576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722000577	active site
743722000578	phosphorylation site [posttranslational modification]
743722000579	intermolecular recognition site; other site
743722000580	dimerization interface [polypeptide binding]; other site
743722000581	LytTr DNA-binding domain; Region: LytTR; pfam04397
743722000582	Histidine kinase; Region: His_kinase; pfam06580
743722000583	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
743722000584	putative acyl-acceptor binding pocket; other site
743722000585	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
743722000586	Walker A motif; other site
743722000587	ATP binding site [chemical binding]; other site
743722000588	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
743722000589	AAA domain; Region: AAA_12; pfam13087
743722000590	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
743722000591	PLD-like domain; Region: PLDc_2; pfam13091
743722000592	putative active site [active]
743722000593	catalytic site [active]
743722000594	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000595	non-specific DNA binding site [nucleotide binding]; other site
743722000596	salt bridge; other site
743722000597	sequence-specific DNA binding site [nucleotide binding]; other site
743722000598	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000599	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000600	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000601	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722000602	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722000603	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722000604	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722000605	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722000606	catalytic residues [active]
743722000607	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
743722000608	Methylamine utilisation protein MauE; Region: MauE; pfam07291
743722000609	YWFCY protein; Region: YWFCY; pfam14293
743722000610	AAA-like domain; Region: AAA_10; pfam12846
743722000611	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
743722000612	Walker B motif; other site
743722000613	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
743722000614	Predicted membrane protein [Function unknown]; Region: COG2311
743722000615	Protein of unknown function (DUF418); Region: DUF418; cl12135
743722000616	Protein of unknown function (DUF418); Region: DUF418; pfam04235
743722000617	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
743722000618	dimerization interface [polypeptide binding]; other site
743722000619	Domain of unknown function (DUF305); Region: DUF305; pfam03713
743722000620	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
743722000621	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722000622	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000623	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
743722000624	metal-binding site [ion binding]
743722000625	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722000626	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743722000627	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722000628	metal-binding site [ion binding]
743722000629	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722000630	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722000631	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
743722000632	Multicopper oxidase; Region: Cu-oxidase; pfam00394
743722000633	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
743722000634	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
743722000635	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722000636	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722000637	motif II; other site
743722000638	Haem-binding domain; Region: Haem_bd; pfam14376
743722000639	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722000640	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722000641	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722000642	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722000643	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722000644	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722000645	Outer membrane efflux protein; Region: OEP; pfam02321
743722000646	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722000647	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722000648	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
743722000649	Heavy-metal-associated domain; Region: HMA; pfam00403
743722000650	metal-binding site [ion binding]
743722000651	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
743722000652	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
743722000653	catalytic residues [active]
743722000654	catalytic nucleophile [active]
743722000655	Recombinase; Region: Recombinase; pfam07508
743722000656	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722000657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722000658	hypothetical protein; Provisional; Region: PRK07236
743722000659	hypothetical protein; Provisional; Region: PRK07588
743722000660	AAA ATPase domain; Region: AAA_15; pfam13175
743722000661	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722000662	Walker A/P-loop; other site
743722000663	ATP binding site [chemical binding]; other site
743722000664	Q-loop/lid; other site
743722000665	Pirin-related protein [General function prediction only]; Region: COG1741
743722000666	Pirin; Region: Pirin; pfam02678
743722000667	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
743722000668	DoxX-like family; Region: DoxX_2; pfam13564
743722000669	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722000670	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722000671	putative transporter; Provisional; Region: PRK11660
743722000672	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
743722000673	Sulfate transporter family; Region: Sulfate_transp; pfam00916
743722000674	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
743722000675	AIPR protein; Region: AIPR; pfam10592
743722000676	integron integrase; Region: integrase_gron; TIGR02249
743722000677	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743722000678	active site
743722000679	DNA binding site [nucleotide binding]
743722000680	Int/Topo IB signature motif; other site
743722000681	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
743722000682	Helix-turn-helix domain; Region: HTH_17; pfam12728
743722000683	Fic family protein [Function unknown]; Region: COG3177
743722000684	Fic/DOC family; Region: Fic; pfam02661
743722000685	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743722000686	non-specific DNA interactions [nucleotide binding]; other site
743722000687	DNA binding site [nucleotide binding]
743722000688	sequence specific DNA binding site [nucleotide binding]; other site
743722000689	putative cAMP binding site [chemical binding]; other site
743722000690	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
743722000691	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
743722000692	Int/Topo IB signature motif; other site
743722000693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743722000694	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743722000695	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
743722000696	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
743722000697	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
743722000698	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
743722000699	active site
743722000700	catalytic site [active]
743722000701	4-alpha-glucanotransferase; Provisional; Region: PRK14508
743722000702	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
743722000703	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
743722000704	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
743722000705	catalytic site [active]
743722000706	active site
743722000707	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
743722000708	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
743722000709	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
743722000710	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
743722000711	active site
743722000712	catalytic site [active]
743722000713	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
743722000714	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
743722000715	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
743722000716	oligomerization interface [polypeptide binding]; other site
743722000717	active site
743722000718	metal binding site [ion binding]; metal-binding site
743722000719	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
743722000720	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
743722000721	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
743722000722	FeoA domain; Region: FeoA; pfam04023
743722000723	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
743722000724	SmpB-tmRNA interface; other site
743722000725	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
743722000726	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722000727	S-adenosylmethionine binding site [chemical binding]; other site
743722000728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722000729	primosomal protein N' Region: priA; TIGR00595
743722000730	ATP binding site [chemical binding]; other site
743722000731	putative Mg++ binding site [ion binding]; other site
743722000732	FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764
743722000733	Zn binding sites [ion binding]; other site
743722000734	phosphatidylinositol 3-phosphate binding site [chemical binding]; other site
743722000735	helicase superfamily c-terminal domain; Region: HELICc; smart00490
743722000736	ATP-binding site [chemical binding]; other site
743722000737	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
743722000738	PQQ-like domain; Region: PQQ_2; pfam13360
743722000739	Glycoprotease family; Region: Peptidase_M22; pfam00814
743722000740	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
743722000741	Haemolytic domain; Region: Haemolytic; pfam01809
743722000742	ribonuclease P; Reviewed; Region: rnpA; PRK01903
743722000743	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
743722000744	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
743722000745	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
743722000746	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
743722000747	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
743722000748	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
743722000749	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
743722000750	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
743722000751	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
743722000752	putative active site; other site
743722000753	catalytic triad [active]
743722000754	putative dimer interface [polypeptide binding]; other site
743722000755	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
743722000756	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
743722000757	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
743722000758	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
743722000759	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
743722000760	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
743722000761	catalytic site [active]
743722000762	subunit interface [polypeptide binding]; other site
743722000763	enolase; Provisional; Region: eno; PRK00077
743722000764	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
743722000765	dimer interface [polypeptide binding]; other site
743722000766	metal binding site [ion binding]; metal-binding site
743722000767	substrate binding pocket [chemical binding]; other site
743722000768	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
743722000769	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
743722000770	NAD(P) binding site [chemical binding]; other site
743722000771	homotetramer interface [polypeptide binding]; other site
743722000772	homodimer interface [polypeptide binding]; other site
743722000773	active site
743722000774	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
743722000775	ribonucleoside--diphosphate reductase large subunit; Region: PLN02437
743722000776	ATP cone domain; Region: ATP-cone; pfam03477
743722000777	Class I ribonucleotide reductase; Region: RNR_I; cd01679
743722000778	active site
743722000779	dimer interface [polypeptide binding]; other site
743722000780	catalytic residues [active]
743722000781	effector binding site; other site
743722000782	R2 peptide binding site; other site
743722000783	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
743722000784	dimer interface [polypeptide binding]; other site
743722000785	putative radical transfer pathway; other site
743722000786	diiron center [ion binding]; other site
743722000787	tyrosyl radical; other site
743722000788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722000789	Walker A/P-loop; other site
743722000790	ATP binding site [chemical binding]; other site
743722000791	Q-loop/lid; other site
743722000792	ABC transporter signature motif; other site
743722000793	Walker B; other site
743722000794	D-loop; other site
743722000795	H-loop/switch region; other site
743722000796	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722000797	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722000798	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722000799	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
743722000800	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
743722000801	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
743722000802	active site
743722000803	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
743722000804	purine nucleoside phosphorylase; Provisional; Region: PRK08202
743722000805	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
743722000806	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
743722000807	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
743722000808	Glutamate binding site [chemical binding]; other site
743722000809	NAD binding site [chemical binding]; other site
743722000810	catalytic residues [active]
743722000811	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722000812	Coenzyme A binding pocket [chemical binding]; other site
743722000813	Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; Region: SRPBCC_Aha1; cd08892
743722000814	putative hydrophobic ligand binding site [chemical binding]; other site
743722000815	putative Hsp90 binding residues [polypeptide binding]; other site
743722000816	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743722000817	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743722000818	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
743722000819	intracellular protease, PfpI family; Region: PfpI; TIGR01382
743722000820	proposed catalytic triad [active]
743722000821	conserved cys residue [active]
743722000822	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
743722000823	putative hydrophobic ligand binding site [chemical binding]; other site
743722000824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
743722000825	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
743722000826	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
743722000827	DinB family; Region: DinB; cl17821
743722000828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722000829	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722000830	putative substrate translocation pore; other site
743722000831	GTPase Era; Reviewed; Region: era; PRK00089
743722000832	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
743722000833	G1 box; other site
743722000834	GTP/Mg2+ binding site [chemical binding]; other site
743722000835	Switch I region; other site
743722000836	G2 box; other site
743722000837	Switch II region; other site
743722000838	G3 box; other site
743722000839	G4 box; other site
743722000840	G5 box; other site
743722000841	KH domain; Region: KH_2; pfam07650
743722000842	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
743722000843	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
743722000844	Transposase; Region: DDE_Tnp_ISL3; pfam01610
743722000845	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
743722000846	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
743722000847	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722000848	Ligand Binding Site [chemical binding]; other site
743722000849	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722000850	Ligand Binding Site [chemical binding]; other site
743722000851	Protein of unknown function (DUF402); Region: DUF402; cl00979
743722000852	GTP-binding protein Der; Reviewed; Region: PRK00093
743722000853	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
743722000854	G1 box; other site
743722000855	GTP/Mg2+ binding site [chemical binding]; other site
743722000856	Switch I region; other site
743722000857	G2 box; other site
743722000858	Switch II region; other site
743722000859	G3 box; other site
743722000860	G4 box; other site
743722000861	G5 box; other site
743722000862	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
743722000863	G1 box; other site
743722000864	GTP/Mg2+ binding site [chemical binding]; other site
743722000865	Switch I region; other site
743722000866	G2 box; other site
743722000867	G3 box; other site
743722000868	Switch II region; other site
743722000869	G4 box; other site
743722000870	G5 box; other site
743722000871	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722000872	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722000873	DNA binding site [nucleotide binding]
743722000874	domain linker motif; other site
743722000875	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722000876	dimerization interface [polypeptide binding]; other site
743722000877	ligand binding site [chemical binding]; other site
743722000878	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
743722000879	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
743722000880	active site
743722000881	trimer interface [polypeptide binding]; other site
743722000882	allosteric site; other site
743722000883	active site lid [active]
743722000884	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743722000885	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722000886	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722000887	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722000888	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722000889	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722000890	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000891	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000892	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722000893	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722000894	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722000895	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
743722000896	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
743722000897	protein binding site [polypeptide binding]; other site
743722000898	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
743722000899	Catalytic dyad [active]
743722000900	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
743722000901	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
743722000902	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
743722000903	substrate binding pocket [chemical binding]; other site
743722000904	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
743722000905	B12 binding site [chemical binding]; other site
743722000906	cobalt ligand [ion binding]; other site
743722000907	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
743722000908	four helix bundle protein; Region: TIGR02436
743722000909	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
743722000910	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
743722000911	FAD binding site [chemical binding]; other site
743722000912	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
743722000913	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000914	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000915	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000916	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
743722000917	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722000918	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722000919	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722000920	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722000921	active site residue [active]
743722000922	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722000923	catalytic residues [active]
743722000924	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
743722000925	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722000926	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722000927	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722000928	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722000929	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722000930	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722000931	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722000932	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722000933	Sulfatase; Region: Sulfatase; pfam00884
743722000934	Sulfatase; Region: Sulfatase; cl17466
743722000935	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722000936	active site residue [active]
743722000937	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722000938	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722000939	catalytic residues [active]
743722000940	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
743722000941	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
743722000942	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
743722000943	gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530
743722000944	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722000945	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
743722000946	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
743722000947	Walker A/P-loop; other site
743722000948	ATP binding site [chemical binding]; other site
743722000949	Q-loop/lid; other site
743722000950	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
743722000951	ABC transporter signature motif; other site
743722000952	Walker B; other site
743722000953	D-loop; other site
743722000954	H-loop/switch region; other site
743722000955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722000956	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
743722000957	NAD(P) binding site [chemical binding]; other site
743722000958	active site
743722000959	AAA domain; Region: AAA_14; pfam13173
743722000960	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722000961	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743722000962	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722000963	non-specific DNA binding site [nucleotide binding]; other site
743722000964	salt bridge; other site
743722000965	sequence-specific DNA binding site [nucleotide binding]; other site
743722000966	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
743722000967	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
743722000968	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
743722000969	Clp amino terminal domain; Region: Clp_N; pfam02861
743722000970	Clp amino terminal domain; Region: Clp_N; pfam02861
743722000971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722000972	Walker A motif; other site
743722000973	ATP binding site [chemical binding]; other site
743722000974	Walker B motif; other site
743722000975	arginine finger; other site
743722000976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722000977	Walker A motif; other site
743722000978	ATP binding site [chemical binding]; other site
743722000979	Walker B motif; other site
743722000980	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
743722000981	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
743722000982	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722000983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722000984	Walker A/P-loop; other site
743722000985	ATP binding site [chemical binding]; other site
743722000986	Q-loop/lid; other site
743722000987	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722000988	ABC transporter signature motif; other site
743722000989	ABC transporter; Region: ABC_tran_2; pfam12848
743722000990	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722000991	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
743722000992	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743722000993	Protein of unknown function (DUF458); Region: DUF458; cl00861
743722000994	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722000995	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722000996	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722000997	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722000998	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722000999	catalytic residues [active]
743722001000	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
743722001001	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722001002	Walker A/P-loop; other site
743722001003	ATP binding site [chemical binding]; other site
743722001004	Q-loop/lid; other site
743722001005	ABC transporter signature motif; other site
743722001006	Walker B; other site
743722001007	D-loop; other site
743722001008	H-loop/switch region; other site
743722001009	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722001010	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722001011	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722001012	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722001013	DNA binding residues [nucleotide binding]
743722001014	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
743722001015	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722001016	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722001017	E3 interaction surface; other site
743722001018	lipoyl attachment site [posttranslational modification]; other site
743722001019	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722001020	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722001021	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
743722001022	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
743722001023	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
743722001024	Catalytic site [active]
743722001025	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
743722001026	dihydrodipicolinate reductase; Provisional; Region: PRK00048
743722001027	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
743722001028	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
743722001029	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
743722001030	ParB-like nuclease domain; Region: ParB; smart00470
743722001031	KorB domain; Region: KorB; pfam08535
743722001032	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
743722001033	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743722001034	P-loop; other site
743722001035	Magnesium ion binding site [ion binding]; other site
743722001036	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743722001037	Magnesium ion binding site [ion binding]; other site
743722001038	Predicted flavoprotein [General function prediction only]; Region: COG0431
743722001039	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722001040	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722001041	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
743722001042	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722001043	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001044	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001045	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001046	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001047	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001048	SusD family; Region: SusD; pfam07980
743722001049	polyol permease family; Region: 2A0118; TIGR00897
743722001050	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722001051	putative substrate translocation pore; other site
743722001052	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
743722001053	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171
743722001054	putative ligand binding site [chemical binding]; other site
743722001055	putative NAD binding site [chemical binding]; other site
743722001056	catalytic site [active]
743722001057	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
743722001058	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722001059	nucleotide binding site [chemical binding]; other site
743722001060	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
743722001061	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722001062	nucleotide binding site [chemical binding]; other site
743722001063	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743722001064	catalytic core [active]
743722001065	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743722001066	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
743722001067	putative active site [active]
743722001068	catalytic site [active]
743722001069	putative metal binding site [ion binding]; other site
743722001070	oligomer interface [polypeptide binding]; other site
743722001071	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722001072	DNA-binding site [nucleotide binding]; DNA binding site
743722001073	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
743722001074	putative ligand binding site [chemical binding]; other site
743722001075	putative dimerization interface [polypeptide binding]; other site
743722001076	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722001077	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
743722001078	oligomeric interface; other site
743722001079	putative active site [active]
743722001080	homodimer interface [polypeptide binding]; other site
743722001081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722001082	non-specific DNA binding site [nucleotide binding]; other site
743722001083	salt bridge; other site
743722001084	sequence-specific DNA binding site [nucleotide binding]; other site
743722001085	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
743722001086	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722001087	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
743722001088	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722001089	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722001090	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743722001091	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
743722001092	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
743722001093	active site
743722001094	metal binding site [ion binding]; metal-binding site
743722001095	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
743722001096	UbiA prenyltransferase family; Region: UbiA; pfam01040
743722001097	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
743722001098	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722001099	active site
743722001100	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722001101	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001102	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001103	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722001104	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743722001105	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
743722001106	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
743722001107	active site
743722001108	catalytic residues [active]
743722001109	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
743722001110	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
743722001111	Cytochrome c; Region: Cytochrom_C; pfam00034
743722001112	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001113	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001114	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722001115	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001116	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001117	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001118	FecR protein; Region: FecR; pfam04773
743722001119	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722001120	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722001121	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722001122	DNA binding residues [nucleotide binding]
743722001123	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
743722001124	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722001125	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722001126	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001127	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001128	Domain of unknown function (DUF718); Region: DUF718; pfam05336
743722001129	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722001130	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
743722001131	active site
743722001132	catalytic triad [active]
743722001133	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
743722001134	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_1; cd11747
743722001135	homodimer interface [polypeptide binding]; other site
743722001136	Protein of unknown function, DUF608; Region: DUF608; pfam04685
743722001137	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
743722001138	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722001139	Pectate lyase; Region: Pec_lyase_C; cl01593
743722001140	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
743722001141	active site
743722001142	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001143	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001144	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001145	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001146	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001147	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001148	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722001149	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722001150	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722001151	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001152	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001153	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001154	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001155	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001156	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001157	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001158	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001159	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001160	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001161	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001162	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722001163	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722001164	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722001165	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722001166	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722001167	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722001168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722001169	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722001170	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722001171	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722001172	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722001173	DNA binding residues [nucleotide binding]
743722001174	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
743722001175	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
743722001176	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722001177	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722001178	FecR protein; Region: FecR; pfam04773
743722001179	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001180	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001181	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722001182	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722001183	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001184	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001185	SusD family; Region: SusD; pfam07980
743722001186	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
743722001187	active site
743722001188	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722001189	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
743722001190	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722001191	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001192	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001193	SusD family; Region: SusD; pfam07980
743722001194	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001195	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001196	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001197	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001198	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722001199	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001200	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001201	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001202	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001203	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722001204	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001205	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722001206	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722001207	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722001208	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722001209	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722001210	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
743722001211	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722001212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722001213	active site
743722001214	phosphorylation site [posttranslational modification]
743722001215	intermolecular recognition site; other site
743722001216	dimerization interface [polypeptide binding]; other site
743722001217	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722001218	DNA binding site [nucleotide binding]
743722001219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722001220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
743722001221	dimer interface [polypeptide binding]; other site
743722001222	phosphorylation site [posttranslational modification]
743722001223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722001224	ATP binding site [chemical binding]; other site
743722001225	Mg2+ binding site [ion binding]; other site
743722001226	G-X-G motif; other site
743722001227	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722001228	nucleotide binding site [chemical binding]; other site
743722001229	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
743722001230	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
743722001231	short chain dehydrogenase; Validated; Region: PRK08324
743722001232	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
743722001233	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722001234	NAD(P) binding site [chemical binding]; other site
743722001235	active site
743722001236	rhamnose-proton symporter; Provisional; Region: PRK13499
743722001237	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
743722001238	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722001239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722001240	Coenzyme A binding pocket [chemical binding]; other site
743722001241	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722001242	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722001243	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722001244	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722001245	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722001246	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722001247	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001248	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722001249	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001250	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
743722001251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722001252	ATP binding site [chemical binding]; other site
743722001253	putative Mg++ binding site [ion binding]; other site
743722001254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722001255	nucleotide binding region [chemical binding]; other site
743722001256	ATP-binding site [chemical binding]; other site
743722001257	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
743722001258	putative NAD(P) binding site [chemical binding]; other site
743722001259	homodimer interface [polypeptide binding]; other site
743722001260	Uncharacterized conserved protein [Function unknown]; Region: COG2353
743722001261	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
743722001262	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
743722001263	catalytic nucleophile [active]
743722001264	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743722001265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722001266	putative DNA binding site [nucleotide binding]; other site
743722001267	putative Zn2+ binding site [ion binding]; other site
743722001268	AsnC family; Region: AsnC_trans_reg; pfam01037
743722001269	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
743722001270	EamA-like transporter family; Region: EamA; pfam00892
743722001271	EamA-like transporter family; Region: EamA; pfam00892
743722001272	DinB family; Region: DinB; cl17821
743722001273	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722001274	Zn2+ binding site [ion binding]; other site
743722001275	Mg2+ binding site [ion binding]; other site
743722001276	polyphosphate kinase; Provisional; Region: PRK05443
743722001277	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
743722001278	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
743722001279	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
743722001280	domain interface [polypeptide binding]; other site
743722001281	active site
743722001282	catalytic site [active]
743722001283	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
743722001284	domain interface [polypeptide binding]; other site
743722001285	active site
743722001286	catalytic site [active]
743722001287	SdiA-regulated; Region: SdiA-regulated; cd09971
743722001288	putative active site [active]
743722001289	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722001290	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722001291	active site
743722001292	metal binding site [ion binding]; metal-binding site
743722001293	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722001294	GAF domain; Region: GAF_2; pfam13185
743722001295	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
743722001296	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
743722001297	active site
743722001298	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722001299	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722001300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722001301	Walker A/P-loop; other site
743722001302	ATP binding site [chemical binding]; other site
743722001303	Q-loop/lid; other site
743722001304	ABC transporter signature motif; other site
743722001305	Walker B; other site
743722001306	D-loop; other site
743722001307	H-loop/switch region; other site
743722001308	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743722001309	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722001310	DNA-binding site [nucleotide binding]; DNA binding site
743722001311	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722001312	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722001313	homodimer interface [polypeptide binding]; other site
743722001314	catalytic residue [active]
743722001315	Uncharacterized conserved protein [Function unknown]; Region: COG2128
743722001316	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
743722001317	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
743722001318	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722001319	putative catalytic residue [active]
743722001320	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722001321	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722001322	catalytic residues [active]
743722001323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722001324	Coenzyme A binding pocket [chemical binding]; other site
743722001325	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743722001326	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722001327	Coenzyme A binding pocket [chemical binding]; other site
743722001328	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
743722001329	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
743722001330	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722001331	active site
743722001332	HIGH motif; other site
743722001333	nucleotide binding site [chemical binding]; other site
743722001334	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
743722001335	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722001336	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722001337	active site
743722001338	KMSKS motif; other site
743722001339	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
743722001340	tRNA binding surface [nucleotide binding]; other site
743722001341	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
743722001342	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
743722001343	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
743722001344	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
743722001345	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
743722001346	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
743722001347	RNA binding site [nucleotide binding]; other site
743722001348	active site
743722001349	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
743722001350	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
743722001351	active site
743722001352	Riboflavin kinase; Region: Flavokinase; pfam01687
743722001353	Uncharacterized conserved protein [Function unknown]; Region: COG2353
743722001354	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
743722001355	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
743722001356	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743722001357	homodimer interface [polypeptide binding]; other site
743722001358	substrate-cofactor binding pocket; other site
743722001359	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722001360	catalytic residue [active]
743722001361	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
743722001362	active site
743722001363	SAM binding site [chemical binding]; other site
743722001364	homodimer interface [polypeptide binding]; other site
743722001365	Predicted transcriptional regulator [Transcription]; Region: COG1959
743722001366	Transcriptional regulator; Region: Rrf2; pfam02082
743722001367	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
743722001368	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743722001369	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743722001370	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
743722001371	RNA polymerase sigma factor; Provisional; Region: PRK12513
743722001372	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722001373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722001374	DNA binding residues [nucleotide binding]
743722001375	Uncharacterized conserved protein [Function unknown]; Region: COG4850
743722001376	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
743722001377	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
743722001378	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
743722001379	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001380	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001381	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
743722001382	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
743722001383	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
743722001384	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
743722001385	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
743722001386	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
743722001387	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
743722001388	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
743722001389	dimerization interface [polypeptide binding]; other site
743722001390	active site
743722001391	Family of unknown function (DUF490); Region: DUF490; pfam04357
743722001392	UGMP family protein; Validated; Region: PRK09604
743722001393	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
743722001394	recombinase A; Provisional; Region: recA; PRK09354
743722001395	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
743722001396	hexamer interface [polypeptide binding]; other site
743722001397	Walker A motif; other site
743722001398	ATP binding site [chemical binding]; other site
743722001399	Walker B motif; other site
743722001400	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
743722001401	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743722001402	minor groove reading motif; other site
743722001403	helix-hairpin-helix signature motif; other site
743722001404	substrate binding pocket [chemical binding]; other site
743722001405	active site
743722001406	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
743722001407	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
743722001408	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
743722001409	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
743722001410	active site
743722001411	catalytic triad [active]
743722001412	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
743722001413	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
743722001414	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
743722001415	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722001416	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722001417	DNA binding site [nucleotide binding]
743722001418	domain linker motif; other site
743722001419	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722001420	dimerization interface [polypeptide binding]; other site
743722001421	ligand binding site [chemical binding]; other site
743722001422	Glucuronate isomerase; Region: UxaC; pfam02614
743722001423	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
743722001424	mannonate dehydratase; Provisional; Region: PRK03906
743722001425	mannonate dehydratase; Region: uxuA; TIGR00695
743722001426	D-mannonate oxidoreductase; Provisional; Region: PRK08277
743722001427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722001428	NAD(P) binding site [chemical binding]; other site
743722001429	active site
743722001430	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743722001431	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
743722001432	substrate binding site [chemical binding]; other site
743722001433	ATP binding site [chemical binding]; other site
743722001434	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
743722001435	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
743722001436	active site
743722001437	intersubunit interface [polypeptide binding]; other site
743722001438	catalytic residue [active]
743722001439	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001440	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001441	BNR repeat-like domain; Region: BNR_2; pfam13088
743722001442	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001443	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001444	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001445	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001446	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001447	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722001448	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722001449	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
743722001450	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
743722001451	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
743722001452	putative active site [active]
743722001453	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722001454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722001455	Walker A/P-loop; other site
743722001456	ATP binding site [chemical binding]; other site
743722001457	Q-loop/lid; other site
743722001458	ABC transporter signature motif; other site
743722001459	Walker B; other site
743722001460	D-loop; other site
743722001461	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
743722001462	putative substrate binding site [chemical binding]; other site
743722001463	active site
743722001464	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722001465	active site
743722001466	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
743722001467	putative substrate binding site [chemical binding]; other site
743722001468	active site
743722001469	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
743722001470	active site
743722001471	catalytic residues [active]
743722001472	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722001473	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722001474	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722001475	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
743722001476	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722001477	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
743722001478	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722001479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722001480	Protein of unknown function (DUF3823); Region: DUF3823; pfam12866
743722001481	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001482	SusD family; Region: SusD; pfam07980
743722001483	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001484	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001485	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001486	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722001487	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
743722001488	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722001489	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722001490	DNA binding site [nucleotide binding]
743722001491	domain linker motif; other site
743722001492	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722001493	dimerization interface [polypeptide binding]; other site
743722001494	ligand binding site [chemical binding]; other site
743722001495	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743722001496	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
743722001497	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
743722001498	Protein of unknown function, DUF608; Region: DUF608; pfam04685
743722001499	ribulokinase; Provisional; Region: PRK04123
743722001500	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
743722001501	N- and C-terminal domain interface [polypeptide binding]; other site
743722001502	active site
743722001503	MgATP binding site [chemical binding]; other site
743722001504	catalytic site [active]
743722001505	metal binding site [ion binding]; metal-binding site
743722001506	carbohydrate binding site [chemical binding]; other site
743722001507	homodimer interface [polypeptide binding]; other site
743722001508	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722001509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722001510	putative substrate translocation pore; other site
743722001511	L-fucose isomerase; Provisional; Region: fucI; PRK10991
743722001512	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
743722001513	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743722001514	trimer interface [polypeptide binding]; other site
743722001515	substrate binding site [chemical binding]; other site
743722001516	Mn binding site [ion binding]; other site
743722001517	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
743722001518	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
743722001519	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001520	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001521	SusD family; Region: SusD; pfam07980
743722001522	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001523	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001524	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001525	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722001526	short chain dehydrogenase; Provisional; Region: PRK08628
743722001527	classical (c) SDRs; Region: SDR_c; cd05233
743722001528	NAD(P) binding site [chemical binding]; other site
743722001529	active site
743722001530	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
743722001531	Amidohydrolase; Region: Amidohydro_2; pfam04909
743722001532	active site
743722001533	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
743722001534	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
743722001535	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
743722001536	classical (c) SDRs; Region: SDR_c; cd05233
743722001537	NAD(P) binding site [chemical binding]; other site
743722001538	active site
743722001539	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
743722001540	galactarate dehydratase; Region: galactar-dH20; TIGR03248
743722001541	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
743722001542	Domain of unknown function (DUF718); Region: DUF718; pfam05336
743722001543	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722001544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722001545	putative substrate translocation pore; other site
743722001546	Cupin domain; Region: Cupin_2; cl17218
743722001547	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722001548	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722001549	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722001550	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001551	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001552	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001553	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001554	Trehalose utilisation; Region: ThuA; pfam06283
743722001555	conserved cys residue [active]
743722001556	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722001557	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722001558	DNA binding site [nucleotide binding]
743722001559	domain linker motif; other site
743722001560	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722001561	dimerization interface [polypeptide binding]; other site
743722001562	ligand binding site [chemical binding]; other site
743722001563	Methane oxygenase PmoA; Region: PmoA; pfam14100
743722001564	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001565	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722001566	SusD family; Region: SusD; pfam07980
743722001567	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001568	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001569	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722001570	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001571	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722001572	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001573	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001574	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722001575	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722001576	SusD family; Region: SusD; pfam07980
743722001577	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
743722001578	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722001579	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722001580	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722001581	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001582	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001583	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722001584	MG2 domain; Region: A2M_N; pfam01835
743722001585	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722001586	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722001587	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001588	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
743722001589	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722001590	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722001591	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722001592	DNA binding residues [nucleotide binding]
743722001593	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001594	von Willebrand factor; Region: vWF_A; pfam12450
743722001595	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
743722001596	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
743722001597	metal ion-dependent adhesion site (MIDAS); other site
743722001598	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
743722001599	Predicted esterase [General function prediction only]; Region: COG0400
743722001600	putative hydrolase; Provisional; Region: PRK11460
743722001601	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
743722001602	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722001603	Zn binding site [ion binding]; other site
743722001604	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
743722001605	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722001606	Zn binding site [ion binding]; other site
743722001607	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
743722001608	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
743722001609	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
743722001610	active site
743722001611	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722001612	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001613	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722001614	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722001615	histidine decarboxylase; Provisional; Region: PRK02769
743722001616	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722001617	catalytic residue [active]
743722001618	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743722001619	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722001620	putative DNA binding site [nucleotide binding]; other site
743722001621	putative Zn2+ binding site [ion binding]; other site
743722001622	AsnC family; Region: AsnC_trans_reg; pfam01037
743722001623	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722001624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722001625	active site
743722001626	phosphorylation site [posttranslational modification]
743722001627	intermolecular recognition site; other site
743722001628	dimerization interface [polypeptide binding]; other site
743722001629	LytTr DNA-binding domain; Region: LytTR; smart00850
743722001630	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722001631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722001632	binding surface
743722001633	TPR motif; other site
743722001634	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722001635	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722001636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722001637	binding surface
743722001638	TPR motif; other site
743722001639	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722001640	Histidine kinase; Region: His_kinase; pfam06580
743722001641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722001642	Mg2+ binding site [ion binding]; other site
743722001643	G-X-G motif; other site
743722001644	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
743722001645	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
743722001646	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
743722001647	active site
743722001648	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
743722001649	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
743722001650	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
743722001651	active site
743722001652	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
743722001653	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722001654	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
743722001655	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722001656	sugar binding site [chemical binding]; other site
743722001657	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
743722001658	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
743722001659	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
743722001660	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
743722001661	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743722001662	Cysteine-rich domain; Region: CCG; pfam02754
743722001663	Cysteine-rich domain; Region: CCG; pfam02754
743722001664	Phosphoesterase family; Region: Phosphoesterase; pfam04185
743722001665	LMP repeated region; Region: LMP; pfam04778
743722001666	Phosphoesterase family; Region: Phosphoesterase; pfam04185
743722001667	Domain of unknown function (DUF756); Region: DUF756; pfam05506
743722001668	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
743722001669	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
743722001670	NAD(P) binding site [chemical binding]; other site
743722001671	catalytic residues [active]
743722001672	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
743722001673	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
743722001674	catalytic triad [active]
743722001675	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
743722001676	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
743722001677	putative active site [active]
743722001678	metal binding site [ion binding]; metal-binding site
743722001679	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
743722001680	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
743722001681	ethanolamine permease; Region: 2A0305; TIGR00908
743722001682	Predicted membrane protein (DUF2101); Region: DUF2101; cl01648
743722001683	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
743722001684	hypothetical protein; Reviewed; Region: PRK12497
743722001685	DNA primase, catalytic core; Region: dnaG; TIGR01391
743722001686	CHC2 zinc finger; Region: zf-CHC2; pfam01807
743722001687	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
743722001688	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
743722001689	active site
743722001690	metal binding site [ion binding]; metal-binding site
743722001691	interdomain interaction site; other site
743722001692	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743722001693	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743722001694	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
743722001695	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
743722001696	metal binding site [ion binding]; metal-binding site
743722001697	dimer interface [polypeptide binding]; other site
743722001698	Sporulation related domain; Region: SPOR; pfam05036
743722001699	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
743722001700	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
743722001701	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722001702	nucleotide binding region [chemical binding]; other site
743722001703	ATP-binding site [chemical binding]; other site
743722001704	SEC-C motif; Region: SEC-C; pfam02810
743722001705	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
743722001706	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
743722001707	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
743722001708	active site
743722001709	dimer interface [polypeptide binding]; other site
743722001710	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
743722001711	dimer interface [polypeptide binding]; other site
743722001712	active site
743722001713	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722001714	peptide chain release factor 2; Validated; Region: prfB; PRK00578
743722001715	This domain is found in peptide chain release factors; Region: PCRF; smart00937
743722001716	RF-1 domain; Region: RF-1; pfam00472
743722001717	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
743722001718	trimer interface [polypeptide binding]; other site
743722001719	active site
743722001720	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
743722001721	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
743722001722	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001723	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722001724	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722001725	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722001726	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722001727	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722001728	Peptidase family S41; Region: Peptidase_S41; pfam03572
743722001729	Active site serine [active]
743722001730	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
743722001731	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
743722001732	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722001733	FeS/SAM binding site; other site
743722001734	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
743722001735	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722001736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722001737	active site
743722001738	phosphorylation site [posttranslational modification]
743722001739	intermolecular recognition site; other site
743722001740	dimerization interface [polypeptide binding]; other site
743722001741	LytTr DNA-binding domain; Region: LytTR; smart00850
743722001742	Histidine kinase; Region: His_kinase; pfam06580
743722001743	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
743722001744	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
743722001745	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
743722001746	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
743722001747	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
743722001748	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
743722001749	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
743722001750	putative active site [active]
743722001751	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722001752	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722001753	Walker A/P-loop; other site
743722001754	ATP binding site [chemical binding]; other site
743722001755	Q-loop/lid; other site
743722001756	ABC transporter signature motif; other site
743722001757	Walker B; other site
743722001758	D-loop; other site
743722001759	H-loop/switch region; other site
743722001760	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
743722001761	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
743722001762	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
743722001763	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
743722001764	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
743722001765	RDD family; Region: RDD; pfam06271
743722001766	Integral membrane protein DUF95; Region: DUF95; pfam01944
743722001767	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
743722001768	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
743722001769	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
743722001770	MoxR-like ATPases [General function prediction only]; Region: COG0714
743722001771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722001772	Walker A motif; other site
743722001773	ATP binding site [chemical binding]; other site
743722001774	Walker B motif; other site
743722001775	arginine finger; other site
743722001776	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
743722001777	Protein of unknown function DUF58; Region: DUF58; pfam01882
743722001778	GH3 auxin-responsive promoter; Region: GH3; pfam03321
743722001779	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
743722001780	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
743722001781	Walker A/P-loop; other site
743722001782	ATP binding site [chemical binding]; other site
743722001783	Q-loop/lid; other site
743722001784	ABC transporter signature motif; other site
743722001785	Walker B; other site
743722001786	D-loop; other site
743722001787	H-loop/switch region; other site
743722001788	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
743722001789	DHH family; Region: DHH; pfam01368
743722001790	DHHA1 domain; Region: DHHA1; pfam02272
743722001791	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722001792	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722001793	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722001794	active site
743722001795	phosphorylation site [posttranslational modification]
743722001796	intermolecular recognition site; other site
743722001797	dimerization interface [polypeptide binding]; other site
743722001798	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722001799	DNA binding residues [nucleotide binding]
743722001800	dimerization interface [polypeptide binding]; other site
743722001801	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722001802	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722001803	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722001804	ATP binding site [chemical binding]; other site
743722001805	Mg2+ binding site [ion binding]; other site
743722001806	G-X-G motif; other site
743722001807	excinuclease ABC subunit B; Provisional; Region: PRK05298
743722001808	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722001809	ATP binding site [chemical binding]; other site
743722001810	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722001811	nucleotide binding region [chemical binding]; other site
743722001812	ATP-binding site [chemical binding]; other site
743722001813	Ultra-violet resistance protein B; Region: UvrB; pfam12344
743722001814	UvrB/uvrC motif; Region: UVR; pfam02151
743722001815	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722001816	active site
743722001817	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
743722001818	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722001819	motif II; other site
743722001820	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722001821	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743722001822	nucleotide binding site [chemical binding]; other site
743722001823	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722001824	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
743722001825	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
743722001826	NADP binding site [chemical binding]; other site
743722001827	homodimer interface [polypeptide binding]; other site
743722001828	active site
743722001829	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
743722001830	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
743722001831	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722001832	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722001833	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722001834	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722001835	DNA binding site [nucleotide binding]
743722001836	domain linker motif; other site
743722001837	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722001838	dimerization interface [polypeptide binding]; other site
743722001839	ligand binding site [chemical binding]; other site
743722001840	CoA binding domain; Region: CoA_binding_2; pfam13380
743722001841	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
743722001842	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
743722001843	LemA family; Region: LemA; pfam04011
743722001844	Repair protein; Region: Repair_PSII; pfam04536
743722001845	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
743722001846	Repair protein; Region: Repair_PSII; pfam04536
743722001847	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
743722001848	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722001849	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
743722001850	putative active site [active]
743722001851	putative metal binding site [ion binding]; other site
743722001852	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722001853	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722001854	NAD(P) binding site [chemical binding]; other site
743722001855	active site
743722001856	phosphoserine phosphatase SerB; Region: serB; TIGR00338
743722001857	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743722001858	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
743722001859	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
743722001860	L-serine binding site [chemical binding]; other site
743722001861	ACT domain interface; other site
743722001862	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
743722001863	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722001864	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722001865	catalytic residues [active]
743722001866	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
743722001867	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
743722001868	homodimer interface [polypeptide binding]; other site
743722001869	substrate-cofactor binding pocket; other site
743722001870	catalytic residue [active]
743722001871	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
743722001872	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
743722001873	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
743722001874	FeS/SAM binding site; other site
743722001875	TRAM domain; Region: TRAM; cl01282
743722001876	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
743722001877	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722001878	Walker A motif; other site
743722001879	ATP binding site [chemical binding]; other site
743722001880	Walker B motif; other site
743722001881	arginine finger; other site
743722001882	Lipopolysaccharide-assembly; Region: LptE; pfam04390
743722001883	Preprotein translocase SecG subunit; Region: SecG; pfam03840
743722001884	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
743722001885	oligomerisation interface [polypeptide binding]; other site
743722001886	mobile loop; other site
743722001887	roof hairpin; other site
743722001888	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
743722001889	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
743722001890	ring oligomerisation interface [polypeptide binding]; other site
743722001891	ATP/Mg binding site [chemical binding]; other site
743722001892	stacking interactions; other site
743722001893	hinge regions; other site
743722001894	YtxH-like protein; Region: YtxH; cl02079
743722001895	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743722001896	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743722001897	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
743722001898	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743722001899	substrate binding site [chemical binding]; other site
743722001900	oxyanion hole (OAH) forming residues; other site
743722001901	trimer interface [polypeptide binding]; other site
743722001902	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
743722001903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
743722001904	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
743722001905	GldH lipoprotein; Region: GldH_lipo; pfam14109
743722001906	PSP1 C-terminal conserved region; Region: PSP1; cl00770
743722001907	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
743722001908	DNA polymerase III subunit delta'; Validated; Region: PRK08485
743722001909	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
743722001910	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
743722001911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722001912	S-adenosylmethionine binding site [chemical binding]; other site
743722001913	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
743722001914	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743722001915	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
743722001916	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743722001917	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722001918	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
743722001919	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
743722001920	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
743722001921	amidase catalytic site [active]
743722001922	Zn binding residues [ion binding]; other site
743722001923	substrate binding site [chemical binding]; other site
743722001924	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
743722001925	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722001926	active site
743722001927	HIGH motif; other site
743722001928	nucleotide binding site [chemical binding]; other site
743722001929	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
743722001930	KMSKS motif; other site
743722001931	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
743722001932	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722001933	DNA-binding site [nucleotide binding]; DNA binding site
743722001934	RNA-binding motif; other site
743722001935	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
743722001936	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743722001937	ATP binding site [chemical binding]; other site
743722001938	Mg++ binding site [ion binding]; other site
743722001939	motif III; other site
743722001940	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722001941	nucleotide binding region [chemical binding]; other site
743722001942	ATP-binding site [chemical binding]; other site
743722001943	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
743722001944	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
743722001945	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722001946	active site
743722001947	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722001948	Amidohydrolase; Region: Amidohydro_4; pfam13147
743722001949	active site
743722001950	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
743722001951	Amidohydrolase; Region: Amidohydro_4; pfam13147
743722001952	active site
743722001953	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
743722001954	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722001955	putative metal binding site [ion binding]; other site
743722001956	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
743722001957	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
743722001958	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
743722001959	dimerization interface [polypeptide binding]; other site
743722001960	DPS ferroxidase diiron center [ion binding]; other site
743722001961	ion pore; other site
743722001962	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
743722001963	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743722001964	chaperone protein DnaJ; Provisional; Region: PRK14299
743722001965	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
743722001966	HSP70 interaction site [polypeptide binding]; other site
743722001967	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
743722001968	substrate binding site [polypeptide binding]; other site
743722001969	dimer interface [polypeptide binding]; other site
743722001970	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
743722001971	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
743722001972	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743722001973	Walker A/P-loop; other site
743722001974	ATP binding site [chemical binding]; other site
743722001975	Q-loop/lid; other site
743722001976	ABC transporter signature motif; other site
743722001977	Walker B; other site
743722001978	D-loop; other site
743722001979	H-loop/switch region; other site
743722001980	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743722001981	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
743722001982	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
743722001983	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
743722001984	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722001985	active site
743722001986	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
743722001987	putative substrate binding site [chemical binding]; other site
743722001988	active site
743722001989	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722001990	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722001991	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722001992	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
743722001993	active site
743722001994	catalytic residues [active]
743722001995	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743722001996	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
743722001997	putative catalytic site [active]
743722001998	putative metal binding site [ion binding]; other site
743722001999	putative phosphate binding site [ion binding]; other site
743722002000	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002001	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002002	SusD family; Region: SusD; pfam07980
743722002003	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002004	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722002005	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002006	FecR protein; Region: FecR; pfam04773
743722002007	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722002008	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002009	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002011	DNA binding residues [nucleotide binding]
743722002012	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002013	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002014	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002015	DNA binding residues [nucleotide binding]
743722002016	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722002017	FecR protein; Region: FecR; pfam04773
743722002018	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002019	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002020	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722002021	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002022	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002023	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002024	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
743722002025	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722002026	putative active site [active]
743722002027	putative metal binding site [ion binding]; other site
743722002028	Family description; Region: VCBS; pfam13517
743722002029	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
743722002030	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743722002031	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722002032	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722002033	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
743722002034	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
743722002035	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722002036	dimer interface [polypeptide binding]; other site
743722002037	conserved gate region; other site
743722002038	putative PBP binding loops; other site
743722002039	ABC-ATPase subunit interface; other site
743722002040	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
743722002041	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
743722002042	Walker A/P-loop; other site
743722002043	ATP binding site [chemical binding]; other site
743722002044	Q-loop/lid; other site
743722002045	ABC transporter signature motif; other site
743722002046	Walker B; other site
743722002047	D-loop; other site
743722002048	H-loop/switch region; other site
743722002049	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
743722002050	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
743722002051	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
743722002052	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
743722002053	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722002054	putative catalytic residues [active]
743722002055	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722002056	catalytic residues [active]
743722002057	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002058	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002059	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
743722002060	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
743722002061	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743722002062	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
743722002063	active site
743722002064	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002065	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002066	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
743722002067	AAA domain; Region: AAA_14; pfam13173
743722002068	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722002069	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002070	FtsX-like permease family; Region: FtsX; pfam02687
743722002071	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
743722002072	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
743722002073	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002074	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
743722002075	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
743722002076	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722002077	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722002078	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722002079	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722002080	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
743722002081	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
743722002082	PA/protease or protease-like domain interface [polypeptide binding]; other site
743722002083	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
743722002084	metal binding site [ion binding]; metal-binding site
743722002085	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743722002086	homotrimer interaction site [polypeptide binding]; other site
743722002087	putative active site [active]
743722002088	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722002089	Sulfatase; Region: Sulfatase; pfam00884
743722002090	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
743722002091	active site
743722002092	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722002093	putative catalytic site [active]
743722002094	putative metal binding site [ion binding]; other site
743722002095	putative phosphate binding site [ion binding]; other site
743722002096	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
743722002097	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002098	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002099	SusD family; Region: SusD; pfam07980
743722002100	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722002101	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002102	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002103	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002104	FecR protein; Region: FecR; pfam04773
743722002105	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002106	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002107	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002108	DNA binding residues [nucleotide binding]
743722002109	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002110	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722002111	FtsX-like permease family; Region: FtsX; pfam02687
743722002112	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722002113	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002114	FtsX-like permease family; Region: FtsX; pfam02687
743722002115	AAA domain; Region: AAA_14; pfam13173
743722002116	AAA domain; Region: AAA_22; pfam13401
743722002117	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722002118	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002119	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002120	AAA domain; Region: AAA_22; pfam13401
743722002121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722002122	Walker A motif; other site
743722002123	ATP binding site [chemical binding]; other site
743722002124	Walker B motif; other site
743722002125	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722002126	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722002127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722002128	Walker A motif; other site
743722002129	ATP binding site [chemical binding]; other site
743722002130	Walker B motif; other site
743722002131	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722002132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722002133	Integrase core domain; Region: rve; pfam00665
743722002134	Histidine kinase; Region: His_kinase; pfam06580
743722002135	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722002136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002137	active site
743722002138	phosphorylation site [posttranslational modification]
743722002139	intermolecular recognition site; other site
743722002140	dimerization interface [polypeptide binding]; other site
743722002141	LytTr DNA-binding domain; Region: LytTR; smart00850
743722002142	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722002143	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
743722002144	DNA-binding interface [nucleotide binding]; DNA binding site
743722002145	Integrase core domain; Region: rve; pfam00665
743722002146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722002147	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722002148	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722002149	Walker A motif; other site
743722002150	ATP binding site [chemical binding]; other site
743722002151	Walker B motif; other site
743722002152	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722002153	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722002154	catalytic residues [active]
743722002155	RibD C-terminal domain; Region: RibD_C; cl17279
743722002156	MarR family; Region: MarR_2; pfam12802
743722002157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722002158	S-adenosylmethionine binding site [chemical binding]; other site
743722002159	nucleosidase; Provisional; Region: PRK05634
743722002160	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
743722002161	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722002162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002163	active site
743722002164	phosphorylation site [posttranslational modification]
743722002165	intermolecular recognition site; other site
743722002166	dimerization interface [polypeptide binding]; other site
743722002167	LytTr DNA-binding domain; Region: LytTR; smart00850
743722002168	Histidine kinase; Region: His_kinase; pfam06580
743722002169	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
743722002170	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722002171	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002172	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002173	phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259
743722002174	NmrA-like family; Region: NmrA; pfam05368
743722002175	NAD(P) binding site [chemical binding]; other site
743722002176	active site lysine
743722002177	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722002178	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
743722002179	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722002180	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002181	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002182	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722002183	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
743722002184	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722002185	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722002186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722002187	Protein of unknown function (DUF2711); Region: DUF2711; pfam10924
743722002188	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722002189	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722002190	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722002191	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722002192	Low affinity iron permease; Region: Iron_permease; pfam04120
743722002193	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722002194	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722002195	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743722002196	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722002197	AAA domain; Region: AAA_18; pfam13238
743722002198	AAA domain; Region: AAA_17; pfam13207
743722002199	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
743722002200	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
743722002201	cofactor binding site; other site
743722002202	DNA binding site [nucleotide binding]
743722002203	substrate interaction site [chemical binding]; other site
743722002204	Pirin-related protein [General function prediction only]; Region: COG1741
743722002205	Pirin; Region: Pirin; pfam02678
743722002206	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
743722002207	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
743722002208	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
743722002209	potential catalytic triad [active]
743722002210	conserved cys residue [active]
743722002211	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722002212	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722002213	ligand binding site [chemical binding]; other site
743722002214	RibD C-terminal domain; Region: RibD_C; cl17279
743722002215	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722002216	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722002217	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722002218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722002219	Walker A/P-loop; other site
743722002220	ATP binding site [chemical binding]; other site
743722002221	Q-loop/lid; other site
743722002222	ABC transporter signature motif; other site
743722002223	Walker B; other site
743722002224	D-loop; other site
743722002225	H-loop/switch region; other site
743722002226	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002227	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002228	short chain dehydrogenase; Provisional; Region: PRK08263
743722002229	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722002230	NADP binding site [chemical binding]; other site
743722002231	active site
743722002232	steroid binding site; other site
743722002233	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743722002234	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
743722002235	Chorismate mutase type II; Region: CM_2; smart00830
743722002236	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722002237	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722002238	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002240	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
743722002241	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722002242	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722002243	S-adenosylmethionine binding site [chemical binding]; other site
743722002244	Methyltransferase domain; Region: Methyltransf_23; pfam13489
743722002245	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722002246	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743722002247	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002248	short chain dehydrogenase; Provisional; Region: PRK06180
743722002249	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722002250	NADP binding site [chemical binding]; other site
743722002251	active site
743722002252	steroid binding site; other site
743722002253	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743722002254	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
743722002255	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722002256	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722002257	Right handed beta helix region; Region: Beta_helix; pfam13229
743722002258	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722002259	Domain of unknown function (DUF1793); Region: DUF1793; pfam08760
743722002260	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722002261	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722002262	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722002263	N-terminal plug; other site
743722002264	ligand-binding site [chemical binding]; other site
743722002265	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
743722002266	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722002267	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002268	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002269	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002270	SusD family; Region: SusD; pfam07980
743722002271	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002272	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002273	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002274	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722002275	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002276	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722002277	active site
743722002278	MFS/sugar transport protein; Region: MFS_2; pfam13347
743722002279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722002280	putative substrate translocation pore; other site
743722002281	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
743722002282	putative active cleft [active]
743722002283	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
743722002284	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
743722002285	putative hydrophobic ligand binding site [chemical binding]; other site
743722002286	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722002287	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722002288	ligand binding site [chemical binding]; other site
743722002289	flexible hinge region; other site
743722002290	short chain dehydrogenase; Provisional; Region: PRK06500
743722002291	classical (c) SDRs; Region: SDR_c; cd05233
743722002292	NAD(P) binding site [chemical binding]; other site
743722002293	active site
743722002294	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002295	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002296	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002297	DNA binding residues [nucleotide binding]
743722002298	FecR protein; Region: FecR; pfam04773
743722002299	Secretin and TonB N terminus short domain; Region: STN; smart00965
743722002300	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002301	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002302	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002303	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722002304	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002305	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002306	SusD family; Region: SusD; pfam07980
743722002307	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722002308	Sulfatase; Region: Sulfatase; pfam00884
743722002309	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722002310	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002312	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722002313	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722002314	active site
743722002315	catalytic tetrad [active]
743722002316	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743722002317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722002318	Coenzyme A binding pocket [chemical binding]; other site
743722002319	DinB family; Region: DinB; cl17821
743722002320	DinB superfamily; Region: DinB_2; pfam12867
743722002321	Nitronate monooxygenase; Region: NMO; pfam03060
743722002322	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
743722002323	FMN binding site [chemical binding]; other site
743722002324	substrate binding site [chemical binding]; other site
743722002325	putative catalytic residue [active]
743722002326	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
743722002327	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722002328	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722002329	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722002330	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
743722002331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722002332	putative substrate translocation pore; other site
743722002333	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
743722002334	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
743722002335	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002337	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722002338	Sulfatase; Region: Sulfatase; pfam00884
743722002339	NIPSNAP; Region: NIPSNAP; pfam07978
743722002340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722002341	dimerization interface [polypeptide binding]; other site
743722002342	putative DNA binding site [nucleotide binding]; other site
743722002343	putative Zn2+ binding site [ion binding]; other site
743722002344	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
743722002345	hydrophobic ligand binding site; other site
743722002346	DoxX-like family; Region: DoxX_2; pfam13564
743722002347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
743722002348	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
743722002349	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743722002350	Protein of unknown function (DUF4256); Region: DUF4256; pfam14066
743722002351	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
743722002352	additional DNA contacts [nucleotide binding]; other site
743722002353	mismatch recognition site; other site
743722002354	active site
743722002355	zinc binding site [ion binding]; other site
743722002356	DNA intercalation site [nucleotide binding]; other site
743722002357	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
743722002358	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722002359	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002360	FtsX-like permease family; Region: FtsX; pfam02687
743722002361	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002362	FtsX-like permease family; Region: FtsX; pfam02687
743722002363	Histidine kinase; Region: His_kinase; pfam06580
743722002364	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722002365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002366	active site
743722002367	phosphorylation site [posttranslational modification]
743722002368	intermolecular recognition site; other site
743722002369	dimerization interface [polypeptide binding]; other site
743722002370	LytTr DNA-binding domain; Region: LytTR; pfam04397
743722002371	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577
743722002372	putative active site [active]
743722002373	catalytic site [active]
743722002374	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
743722002375	dimer interface [polypeptide binding]; other site
743722002376	Alkaline phosphatase homologues; Region: alkPPc; smart00098
743722002377	active site
743722002378	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722002379	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002380	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002381	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002382	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002383	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002384	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722002385	FecR protein; Region: FecR; pfam04773
743722002386	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002387	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002388	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722002389	DNA binding residues [nucleotide binding]
743722002390	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722002391	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722002392	dimerization interface [polypeptide binding]; other site
743722002393	putative DNA binding site [nucleotide binding]; other site
743722002394	putative Zn2+ binding site [ion binding]; other site
743722002395	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
743722002396	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722002397	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743722002398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722002399	Walker A/P-loop; other site
743722002400	ATP binding site [chemical binding]; other site
743722002401	ABC transporter signature motif; other site
743722002402	Walker B; other site
743722002403	D-loop; other site
743722002404	H-loop/switch region; other site
743722002405	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722002406	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
743722002407	active site
743722002408	catalytic residues [active]
743722002409	Two component regulator propeller; Region: Reg_prop; pfam07494
743722002410	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
743722002411	Na binding site [ion binding]; other site
743722002412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
743722002413	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
743722002414	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
743722002415	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743722002416	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743722002417	inhibitor site; inhibition site
743722002418	active site
743722002419	dimer interface [polypeptide binding]; other site
743722002420	catalytic residue [active]
743722002421	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
743722002422	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
743722002423	active site
743722002424	NAD binding site [chemical binding]; other site
743722002425	metal binding site [ion binding]; metal-binding site
743722002426	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722002427	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722002428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002429	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
743722002430	putative amphipathic alpha helix; other site
743722002431	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
743722002432	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722002433	hydroxyglutarate oxidase; Provisional; Region: PRK11728
743722002434	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
743722002435	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
743722002436	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
743722002437	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
743722002438	dimer interface [polypeptide binding]; other site
743722002439	NADP binding site [chemical binding]; other site
743722002440	catalytic residues [active]
743722002441	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743722002442	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743722002443	inhibitor site; inhibition site
743722002444	active site
743722002445	dimer interface [polypeptide binding]; other site
743722002446	catalytic residue [active]
743722002447	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002448	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722002449	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722002450	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
743722002451	proline aminopeptidase P II; Provisional; Region: PRK10879
743722002452	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
743722002453	active site
743722002454	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
743722002455	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722002456	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722002457	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
743722002458	Zn binding site [ion binding]; other site
743722002459	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
743722002460	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722002461	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002462	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002463	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002464	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002465	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722002466	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002467	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002468	DNA binding residues [nucleotide binding]
743722002469	FecR protein; Region: FecR; pfam04773
743722002470	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722002471	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002472	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002473	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002474	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002475	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002476	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
743722002477	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722002478	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722002479	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
743722002480	structural tetrad; other site
743722002481	carboxyl-terminal processing protease; Provisional; Region: PLN00049
743722002482	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722002483	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
743722002484	protein binding site [polypeptide binding]; other site
743722002485	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
743722002486	Domain interface; other site
743722002487	Peptide binding site; other site
743722002488	Active site tetrad [active]
743722002489	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002490	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002491	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002492	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002493	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002494	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002495	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722002496	active site
743722002497	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722002498	sugar binding site [chemical binding]; other site
743722002499	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743722002500	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002501	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002502	SusD family; Region: SusD; pfam07980
743722002503	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002504	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002505	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002506	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722002507	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722002508	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722002509	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722002510	N-terminal plug; other site
743722002511	ligand-binding site [chemical binding]; other site
743722002512	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
743722002513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722002514	putative substrate translocation pore; other site
743722002515	POT family; Region: PTR2; cl17359
743722002516	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002517	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002518	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002519	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002520	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002521	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722002522	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722002523	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
743722002524	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722002525	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722002526	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
743722002527	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
743722002528	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722002529	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743722002530	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722002531	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
743722002532	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
743722002533	active site
743722002534	catalytic residues [active]
743722002535	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722002536	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
743722002537	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
743722002538	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
743722002539	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
743722002540	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
743722002541	nudix motif; other site
743722002542	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
743722002543	ribulokinase; Provisional; Region: PRK04123
743722002544	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
743722002545	N- and C-terminal domain interface [polypeptide binding]; other site
743722002546	active site
743722002547	MgATP binding site [chemical binding]; other site
743722002548	catalytic site [active]
743722002549	metal binding site [ion binding]; metal-binding site
743722002550	carbohydrate binding site [chemical binding]; other site
743722002551	homodimer interface [polypeptide binding]; other site
743722002552	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
743722002553	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
743722002554	intersubunit interface [polypeptide binding]; other site
743722002555	active site
743722002556	Zn2+ binding site [ion binding]; other site
743722002557	L-arabinose isomerase; Provisional; Region: PRK02929
743722002558	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
743722002559	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
743722002560	trimer interface [polypeptide binding]; other site
743722002561	putative substrate binding site [chemical binding]; other site
743722002562	putative metal binding site [ion binding]; other site
743722002563	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
743722002564	putative transporter; Provisional; Region: PRK10484
743722002565	Na binding site [ion binding]; other site
743722002566	substrate binding site [chemical binding]; other site
743722002567	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
743722002568	argininosuccinate synthase; Provisional; Region: PRK13820
743722002569	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743722002570	Ligand Binding Site [chemical binding]; other site
743722002571	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
743722002572	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
743722002573	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
743722002574	four helix bundle protein; Region: TIGR02436
743722002575	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
743722002576	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743722002577	inhibitor-cofactor binding pocket; inhibition site
743722002578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722002579	catalytic residue [active]
743722002580	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
743722002581	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
743722002582	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
743722002583	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
743722002584	nucleotide binding site [chemical binding]; other site
743722002585	N-acetyl-L-glutamate binding site [chemical binding]; other site
743722002586	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
743722002587	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
743722002588	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
743722002589	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
743722002590	metal binding site [ion binding]; metal-binding site
743722002591	dimer interface [polypeptide binding]; other site
743722002592	argininosuccinate lyase; Provisional; Region: PRK00855
743722002593	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
743722002594	active sites [active]
743722002595	tetramer interface [polypeptide binding]; other site
743722002596	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
743722002597	putative nucleotide binding site [chemical binding]; other site
743722002598	uridine monophosphate binding site [chemical binding]; other site
743722002599	homohexameric interface [polypeptide binding]; other site
743722002600	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743722002601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722002602	S-adenosylmethionine binding site [chemical binding]; other site
743722002603	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
743722002604	HemN C-terminal domain; Region: HemN_C; pfam06969
743722002605	short chain dehydrogenase; Provisional; Region: PRK06181
743722002606	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722002607	NAD(P) binding site [chemical binding]; other site
743722002608	active site
743722002609	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
743722002610	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
743722002611	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722002612	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
743722002613	NAD binding site [chemical binding]; other site
743722002614	putative substrate binding site 2 [chemical binding]; other site
743722002615	putative substrate binding site 1 [chemical binding]; other site
743722002616	active site
743722002617	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
743722002618	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
743722002619	NAD binding site [chemical binding]; other site
743722002620	homodimer interface [polypeptide binding]; other site
743722002621	active site
743722002622	substrate binding site [chemical binding]; other site
743722002623	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
743722002624	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
743722002625	NAD binding site [chemical binding]; other site
743722002626	substrate binding site [chemical binding]; other site
743722002627	homodimer interface [polypeptide binding]; other site
743722002628	active site
743722002629	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
743722002630	four helix bundle protein; Region: TIGR02436
743722002631	Rhomboid family; Region: Rhomboid; cl11446
743722002632	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722002633	Radical SAM superfamily; Region: Radical_SAM; pfam04055
743722002634	FeS/SAM binding site; other site
743722002635	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
743722002636	FtsH Extracellular; Region: FtsH_ext; pfam06480
743722002637	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
743722002638	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722002639	Walker A motif; other site
743722002640	ATP binding site [chemical binding]; other site
743722002641	Walker B motif; other site
743722002642	arginine finger; other site
743722002643	Peptidase family M41; Region: Peptidase_M41; pfam01434
743722002644	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
743722002645	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
743722002646	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
743722002647	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
743722002648	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
743722002649	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
743722002650	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
743722002651	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722002652	6-phosphofructokinase; Provisional; Region: PRK03202
743722002653	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
743722002654	active site
743722002655	ADP/pyrophosphate binding site [chemical binding]; other site
743722002656	dimerization interface [polypeptide binding]; other site
743722002657	allosteric effector site; other site
743722002658	fructose-1,6-bisphosphate binding site; other site
743722002659	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743722002660	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722002661	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
743722002662	putative dimerization interface [polypeptide binding]; other site
743722002663	methionine sulfoxide reductase A; Provisional; Region: PRK14054
743722002664	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
743722002665	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743722002666	NAD(P) binding site [chemical binding]; other site
743722002667	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
743722002668	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
743722002669	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
743722002670	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
743722002671	nucleoside/Zn binding site; other site
743722002672	dimer interface [polypeptide binding]; other site
743722002673	catalytic motif [active]
743722002674	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
743722002675	dimer interface [polypeptide binding]; other site
743722002676	putative tRNA-binding site [nucleotide binding]; other site
743722002677	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722002678	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722002679	FtsX-like permease family; Region: FtsX; pfam02687
743722002680	phosphodiesterase YaeI; Provisional; Region: PRK11340
743722002681	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
743722002682	putative active site [active]
743722002683	putative metal binding site [ion binding]; other site
743722002684	ferrochelatase; Reviewed; Region: hemH; PRK00035
743722002685	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
743722002686	C-terminal domain interface [polypeptide binding]; other site
743722002687	active site
743722002688	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
743722002689	active site
743722002690	N-terminal domain interface [polypeptide binding]; other site
743722002691	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
743722002692	LytB protein; Region: LYTB; cl00507
743722002693	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
743722002694	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722002695	putative catalytic site [active]
743722002696	putative metal binding site [ion binding]; other site
743722002697	putative phosphate binding site [ion binding]; other site
743722002698	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
743722002699	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
743722002700	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
743722002701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722002702	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722002703	NAD(P) binding site [chemical binding]; other site
743722002704	active site
743722002705	hypothetical protein; Provisional; Region: PRK12378
743722002706	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
743722002707	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
743722002708	active site
743722002709	dimer interface [polypeptide binding]; other site
743722002710	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
743722002711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722002712	ATP binding site [chemical binding]; other site
743722002713	putative Mg++ binding site [ion binding]; other site
743722002714	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722002715	nucleotide binding region [chemical binding]; other site
743722002716	ATP-binding site [chemical binding]; other site
743722002717	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
743722002718	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
743722002719	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
743722002720	active site
743722002721	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290
743722002722	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722002723	S-adenosylmethionine binding site [chemical binding]; other site
743722002724	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722002725	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538
743722002726	PA/protease or protease-like domain interface [polypeptide binding]; other site
743722002727	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
743722002728	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722002729	metal binding site [ion binding]; metal-binding site
743722002730	PUA domain; Region: PUA; cl00607
743722002731	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
743722002732	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
743722002733	putative RNA binding site [nucleotide binding]; other site
743722002734	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722002735	S-adenosylmethionine binding site [chemical binding]; other site
743722002736	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722002737	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722002738	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722002739	DNA binding residues [nucleotide binding]
743722002740	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
743722002741	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
743722002742	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
743722002743	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
743722002744	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
743722002745	Histidine kinase; Region: His_kinase; pfam06580
743722002746	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722002747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002748	active site
743722002749	phosphorylation site [posttranslational modification]
743722002750	intermolecular recognition site; other site
743722002751	dimerization interface [polypeptide binding]; other site
743722002752	LytTr DNA-binding domain; Region: LytTR; smart00850
743722002753	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002754	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002755	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002756	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002757	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002758	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002759	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722002760	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002761	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002762	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002763	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722002764	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722002765	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722002766	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722002767	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002768	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002769	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002771	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722002772	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722002773	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722002774	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722002775	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722002776	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722002777	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722002778	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
743722002779	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
743722002780	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
743722002781	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
743722002782	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722002783	ATP-dependent DNA ligase; Validated; Region: PRK09247
743722002784	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
743722002785	active site
743722002786	DNA binding site [nucleotide binding]
743722002787	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
743722002788	DNA binding site [nucleotide binding]
743722002789	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
743722002790	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722002791	ATP binding site [chemical binding]; other site
743722002792	putative Mg++ binding site [ion binding]; other site
743722002793	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722002794	nucleotide binding region [chemical binding]; other site
743722002795	ATP-binding site [chemical binding]; other site
743722002796	DEAD/H associated; Region: DEAD_assoc; pfam08494
743722002797	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
743722002798	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722002799	putative active site [active]
743722002800	putative metal binding site [ion binding]; other site
743722002801	Response regulator receiver domain; Region: Response_reg; pfam00072
743722002802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002803	active site
743722002804	phosphorylation site [posttranslational modification]
743722002805	intermolecular recognition site; other site
743722002806	dimerization interface [polypeptide binding]; other site
743722002807	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722002808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722002809	dimer interface [polypeptide binding]; other site
743722002810	phosphorylation site [posttranslational modification]
743722002811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722002812	ATP binding site [chemical binding]; other site
743722002813	Mg2+ binding site [ion binding]; other site
743722002814	G-X-G motif; other site
743722002815	Nitrate and nitrite sensing; Region: NIT; pfam08376
743722002816	GAF domain; Region: GAF_2; pfam13185
743722002817	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722002818	dimer interface [polypeptide binding]; other site
743722002819	phosphorylation site [posttranslational modification]
743722002820	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722002821	ATP binding site [chemical binding]; other site
743722002822	Mg2+ binding site [ion binding]; other site
743722002823	G-X-G motif; other site
743722002824	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
743722002825	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002826	active site
743722002827	phosphorylation site [posttranslational modification]
743722002828	intermolecular recognition site; other site
743722002829	dimerization interface [polypeptide binding]; other site
743722002830	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
743722002831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002832	active site
743722002833	phosphorylation site [posttranslational modification]
743722002834	intermolecular recognition site; other site
743722002835	Response regulator receiver domain; Region: Response_reg; pfam00072
743722002836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002837	active site
743722002838	phosphorylation site [posttranslational modification]
743722002839	intermolecular recognition site; other site
743722002840	dimerization interface [polypeptide binding]; other site
743722002841	Response regulator receiver domain; Region: Response_reg; pfam00072
743722002842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722002843	active site
743722002844	phosphorylation site [posttranslational modification]
743722002845	intermolecular recognition site; other site
743722002846	dimerization interface [polypeptide binding]; other site
743722002847	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
743722002848	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
743722002849	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
743722002850	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
743722002851	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
743722002852	substrate binding pocket [chemical binding]; other site
743722002853	chain length determination region; other site
743722002854	substrate-Mg2+ binding site; other site
743722002855	catalytic residues [active]
743722002856	aspartate-rich region 1; other site
743722002857	active site lid residues [active]
743722002858	aspartate-rich region 2; other site
743722002859	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
743722002860	AAA domain; Region: AAA_28; pfam13521
743722002861	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
743722002862	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
743722002863	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743722002864	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
743722002865	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722002866	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
743722002867	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
743722002868	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
743722002869	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
743722002870	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722002871	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722002872	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722002873	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722002874	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722002875	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722002876	DNA repair protein RadA; Provisional; Region: PRK11823
743722002877	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
743722002878	Walker A motif/ATP binding site; other site
743722002879	ATP binding site [chemical binding]; other site
743722002880	Walker B motif; other site
743722002881	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
743722002882	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
743722002883	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
743722002884	homodimer interface [polypeptide binding]; other site
743722002885	oligonucleotide binding site [chemical binding]; other site
743722002886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722002887	TPR motif; other site
743722002888	TPR repeat; Region: TPR_11; pfam13414
743722002889	binding surface
743722002890	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
743722002891	IHF dimer interface [polypeptide binding]; other site
743722002892	IHF - DNA interface [nucleotide binding]; other site
743722002893	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
743722002894	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743722002895	minor groove reading motif; other site
743722002896	helix-hairpin-helix signature motif; other site
743722002897	substrate binding pocket [chemical binding]; other site
743722002898	active site
743722002899	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
743722002900	DNA binding and oxoG recognition site [nucleotide binding]
743722002901	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
743722002902	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
743722002903	dimer interface [polypeptide binding]; other site
743722002904	ssDNA binding site [nucleotide binding]; other site
743722002905	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743722002906	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
743722002907	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
743722002908	dimer interface [polypeptide binding]; other site
743722002909	anticodon binding site; other site
743722002910	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
743722002911	homodimer interface [polypeptide binding]; other site
743722002912	motif 1; other site
743722002913	active site
743722002914	motif 2; other site
743722002915	GAD domain; Region: GAD; pfam02938
743722002916	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
743722002917	motif 3; other site
743722002918	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
743722002919	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
743722002920	TPP-binding site; other site
743722002921	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743722002922	PYR/PP interface [polypeptide binding]; other site
743722002923	dimer interface [polypeptide binding]; other site
743722002924	TPP binding site [chemical binding]; other site
743722002925	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722002926	ScpA/B protein; Region: ScpA_ScpB; cl00598
743722002927	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
743722002928	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
743722002929	dimer interface [polypeptide binding]; other site
743722002930	active site
743722002931	glycine-pyridoxal phosphate binding site [chemical binding]; other site
743722002932	folate binding site [chemical binding]; other site
743722002933	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
743722002934	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722002935	active site
743722002936	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
743722002937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722002938	FeS/SAM binding site; other site
743722002939	chlorohydrolase; Provisional; Region: PRK08418
743722002940	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722002941	active site
743722002942	Acylphosphatase; Region: Acylphosphatase; pfam00708
743722002943	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722002944	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722002945	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722002946	binding surface
743722002947	TPR motif; other site
743722002948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722002949	binding surface
743722002950	TPR motif; other site
743722002951	TPR repeat; Region: TPR_11; pfam13414
743722002952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722002953	TPR motif; other site
743722002954	binding surface
743722002955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722002956	binding surface
743722002957	TPR repeat; Region: TPR_11; pfam13414
743722002958	TPR motif; other site
743722002959	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
743722002960	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
743722002961	Peptidase family M23; Region: Peptidase_M23; pfam01551
743722002962	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
743722002963	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
743722002964	N-acetyl-D-glucosamine binding site [chemical binding]; other site
743722002965	catalytic residue [active]
743722002966	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743722002967	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743722002968	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
743722002969	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
743722002970	NlpC/P60 family; Region: NLPC_P60; pfam00877
743722002971	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
743722002972	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
743722002973	tetramer interface [polypeptide binding]; other site
743722002974	TPP-binding site [chemical binding]; other site
743722002975	heterodimer interface [polypeptide binding]; other site
743722002976	phosphorylation loop region [posttranslational modification]
743722002977	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722002978	E3 interaction surface; other site
743722002979	lipoyl attachment site [posttranslational modification]; other site
743722002980	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
743722002981	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722002982	E3 interaction surface; other site
743722002983	lipoyl attachment site [posttranslational modification]; other site
743722002984	e3 binding domain; Region: E3_binding; pfam02817
743722002985	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743722002986	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
743722002987	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743722002988	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722002989	M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021
743722002990	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722002991	metal binding site [ion binding]; metal-binding site
743722002992	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722002993	active site residue [active]
743722002994	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
743722002995	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722002996	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722002997	ligand binding site [chemical binding]; other site
743722002998	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743722002999	homotrimer interaction site [polypeptide binding]; other site
743722003000	putative active site [active]
743722003001	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
743722003002	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
743722003003	generic binding surface II; other site
743722003004	ssDNA binding site; other site
743722003005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722003006	ATP binding site [chemical binding]; other site
743722003007	putative Mg++ binding site [ion binding]; other site
743722003008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722003009	nucleotide binding region [chemical binding]; other site
743722003010	ATP-binding site [chemical binding]; other site
743722003011	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
743722003012	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
743722003013	HflX GTPase family; Region: HflX; cd01878
743722003014	G1 box; other site
743722003015	GTP/Mg2+ binding site [chemical binding]; other site
743722003016	Switch I region; other site
743722003017	G2 box; other site
743722003018	G3 box; other site
743722003019	Switch II region; other site
743722003020	G4 box; other site
743722003021	G5 box; other site
743722003022	Ribosome-binding factor A; Region: RBFA; pfam02033
743722003023	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
743722003024	Predicted membrane protein [Function unknown]; Region: COG2860
743722003025	UPF0126 domain; Region: UPF0126; pfam03458
743722003026	UPF0126 domain; Region: UPF0126; pfam03458
743722003027	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
743722003028	active site
743722003029	catalytic residues [active]
743722003030	metal binding site [ion binding]; metal-binding site
743722003031	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722003032	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722003033	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722003034	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722003035	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
743722003036	RNA/DNA hybrid binding site [nucleotide binding]; other site
743722003037	active site
743722003038	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
743722003039	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
743722003040	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
743722003041	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
743722003042	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
743722003043	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743722003044	Low molecular weight phosphatase family; Region: LMWPc; cd00115
743722003045	active site
743722003046	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
743722003047	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003048	ATP binding site [chemical binding]; other site
743722003049	Mg2+ binding site [ion binding]; other site
743722003050	G-X-G motif; other site
743722003051	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
743722003052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722003053	active site
743722003054	phosphorylation site [posttranslational modification]
743722003055	intermolecular recognition site; other site
743722003056	dimerization interface [polypeptide binding]; other site
743722003057	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722003058	Walker A motif; other site
743722003059	ATP binding site [chemical binding]; other site
743722003060	Walker B motif; other site
743722003061	arginine finger; other site
743722003062	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
743722003063	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722003064	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722003065	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722003066	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
743722003067	four helix bundle protein; Region: TIGR02436
743722003068	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743722003069	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722003070	Walker A/P-loop; other site
743722003071	ATP binding site [chemical binding]; other site
743722003072	Q-loop/lid; other site
743722003073	ABC transporter signature motif; other site
743722003074	Walker B; other site
743722003075	D-loop; other site
743722003076	H-loop/switch region; other site
743722003077	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003078	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722003079	FtsX-like permease family; Region: FtsX; pfam02687
743722003080	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003081	FtsX-like permease family; Region: FtsX; pfam02687
743722003082	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003083	FtsX-like permease family; Region: FtsX; pfam02687
743722003084	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003085	FtsX-like permease family; Region: FtsX; pfam02687
743722003086	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003087	FtsX-like permease family; Region: FtsX; pfam02687
743722003088	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003089	FtsX-like permease family; Region: FtsX; pfam02687
743722003090	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003091	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003092	FtsX-like permease family; Region: FtsX; pfam02687
743722003093	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003094	FtsX-like permease family; Region: FtsX; pfam02687
743722003095	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
743722003096	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
743722003097	catalytic core [active]
743722003098	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
743722003099	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
743722003100	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
743722003101	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
743722003102	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003103	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722003104	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722003105	N-terminal plug; other site
743722003106	ligand-binding site [chemical binding]; other site
743722003107	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
743722003108	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
743722003109	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
743722003110	metal ion-dependent adhesion site (MIDAS); other site
743722003111	putative oxidoreductase; Provisional; Region: PRK11579
743722003112	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722003113	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722003114	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
743722003115	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722003116	catalytic loop [active]
743722003117	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
743722003118	iron binding site [ion binding]; other site
743722003119	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
743722003120	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722003121	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
743722003122	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
743722003123	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722003124	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722003125	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
743722003126	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
743722003127	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
743722003128	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722003129	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722003130	putative substrate translocation pore; other site
743722003131	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
743722003132	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743722003133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722003134	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
743722003135	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722003136	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722003137	non-specific DNA binding site [nucleotide binding]; other site
743722003138	salt bridge; other site
743722003139	sequence-specific DNA binding site [nucleotide binding]; other site
743722003140	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003141	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722003142	FtsX-like permease family; Region: FtsX; pfam02687
743722003143	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003144	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722003145	FtsX-like permease family; Region: FtsX; pfam02687
743722003146	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003147	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003148	FtsX-like permease family; Region: FtsX; pfam02687
743722003149	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003150	FtsX-like permease family; Region: FtsX; pfam02687
743722003151	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003152	FtsX-like permease family; Region: FtsX; pfam02687
743722003153	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
743722003154	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003155	FtsX-like permease family; Region: FtsX; pfam02687
743722003156	Acyltransferase family; Region: Acyl_transf_3; pfam01757
743722003157	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
743722003158	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722003159	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722003160	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722003161	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722003162	Predicted integral membrane protein [Function unknown]; Region: COG5616
743722003163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003164	binding surface
743722003165	TPR motif; other site
743722003166	TPR repeat; Region: TPR_11; pfam13414
743722003167	TPR repeat; Region: TPR_11; pfam13414
743722003168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003169	binding surface
743722003170	TPR motif; other site
743722003171	DNA topoisomerase I; Provisional; Region: PRK14973
743722003172	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
743722003173	putative active site [active]
743722003174	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
743722003175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722003176	Coenzyme A binding pocket [chemical binding]; other site
743722003177	Uncharacterized conserved protein [Function unknown]; Region: COG2361
743722003178	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
743722003179	active site
743722003180	NTP binding site [chemical binding]; other site
743722003181	metal binding triad [ion binding]; metal-binding site
743722003182	antibiotic binding site [chemical binding]; other site
743722003183	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003184	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003185	FtsX-like permease family; Region: FtsX; pfam02687
743722003186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003187	FtsX-like permease family; Region: FtsX; pfam02687
743722003188	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003189	FtsX-like permease family; Region: FtsX; pfam02687
743722003190	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003191	FtsX-like permease family; Region: FtsX; pfam02687
743722003192	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
743722003193	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722003194	ATP binding site [chemical binding]; other site
743722003195	putative Mg++ binding site [ion binding]; other site
743722003196	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722003197	nucleotide binding region [chemical binding]; other site
743722003198	ATP-binding site [chemical binding]; other site
743722003199	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003200	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003201	FtsX-like permease family; Region: FtsX; pfam02687
743722003202	FtsX-like permease family; Region: FtsX; pfam02687
743722003203	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003204	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
743722003205	HEPN domain; Region: HEPN; cl00824
743722003206	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
743722003207	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
743722003208	PhnA protein; Region: PhnA; pfam03831
743722003209	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743722003210	Interdomain contacts; other site
743722003211	Cytokine receptor motif; other site
743722003212	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003213	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003214	FtsX-like permease family; Region: FtsX; pfam02687
743722003215	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003216	FtsX-like permease family; Region: FtsX; pfam02687
743722003217	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139
743722003218	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
743722003219	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743722003220	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
743722003221	putative NAD(P) binding site [chemical binding]; other site
743722003222	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003223	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003224	FtsX-like permease family; Region: FtsX; pfam02687
743722003225	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003226	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003227	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722003228	FtsX-like permease family; Region: FtsX; pfam02687
743722003229	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722003230	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003231	FtsX-like permease family; Region: FtsX; pfam02687
743722003232	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003233	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722003234	FtsX-like permease family; Region: FtsX; pfam02687
743722003235	FtsX-like permease family; Region: FtsX; pfam02687
743722003236	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003237	FtsX-like permease family; Region: FtsX; pfam02687
743722003238	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003239	FtsX-like permease family; Region: FtsX; pfam02687
743722003240	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743722003241	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722003242	Walker A/P-loop; other site
743722003243	ATP binding site [chemical binding]; other site
743722003244	Q-loop/lid; other site
743722003245	ABC transporter signature motif; other site
743722003246	Walker B; other site
743722003247	D-loop; other site
743722003248	H-loop/switch region; other site
743722003249	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
743722003250	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
743722003251	Outer membrane efflux protein; Region: OEP; pfam02321
743722003252	Outer membrane efflux protein; Region: OEP; pfam02321
743722003253	Uncharacterized conserved protein [Function unknown]; Region: COG1624
743722003254	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
743722003255	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
743722003256	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
743722003257	Penicillinase repressor; Region: Pencillinase_R; pfam03965
743722003258	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
743722003259	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
743722003260	homotetramer interface [polypeptide binding]; other site
743722003261	ligand binding site [chemical binding]; other site
743722003262	catalytic site [active]
743722003263	NAD binding site [chemical binding]; other site
743722003264	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cl00482
743722003265	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
743722003266	active site
743722003267	hydrophilic channel; other site
743722003268	dimerization interface [polypeptide binding]; other site
743722003269	catalytic residues [active]
743722003270	active site lid [active]
743722003271	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
743722003272	active site
743722003273	multimer interface [polypeptide binding]; other site
743722003274	DHH family; Region: DHH; pfam01368
743722003275	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722003276	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
743722003277	active site
743722003278	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
743722003279	active site
743722003280	homodimer interface [polypeptide binding]; other site
743722003281	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
743722003282	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722003283	Protein of unknown function (DUF2891); Region: DUF2891; pfam11199
743722003284	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003285	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722003286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722003287	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
743722003288	TRAM domain; Region: TRAM; cl01282
743722003289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722003290	S-adenosylmethionine binding site [chemical binding]; other site
743722003291	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
743722003292	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
743722003293	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
743722003294	trehalase; Provisional; Region: treF; PRK13270
743722003295	Trehalase; Region: Trehalase; cl17346
743722003296	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
743722003297	Fatty acid desaturase; Region: FA_desaturase; pfam00487
743722003298	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
743722003299	putative di-iron ligands [ion binding]; other site
743722003300	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722003301	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
743722003302	active site
743722003303	catalytic residues [active]
743722003304	metal binding site [ion binding]; metal-binding site
743722003305	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
743722003306	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
743722003307	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
743722003308	putative acyl-acceptor binding pocket; other site
743722003309	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
743722003310	acyl-CoA synthetase; Validated; Region: PRK09192
743722003311	acyl-activating enzyme (AAE) consensus motif; other site
743722003312	AMP binding site [chemical binding]; other site
743722003313	active site
743722003314	CoA binding site [chemical binding]; other site
743722003315	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
743722003316	Cytochrome P450; Region: p450; pfam00067
743722003317	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
743722003318	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
743722003319	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722003320	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003321	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722003322	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722003323	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722003324	Uncharacterized conserved protein [Function unknown]; Region: COG3391
743722003325	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722003326	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722003327	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722003328	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
743722003329	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
743722003330	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722003331	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722003332	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
743722003333	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
743722003334	Peptidase family M23; Region: Peptidase_M23; pfam01551
743722003335	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
743722003336	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743722003337	NAD binding site [chemical binding]; other site
743722003338	substrate binding site [chemical binding]; other site
743722003339	putative active site [active]
743722003340	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722003341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722003342	DinB superfamily; Region: DinB_2; pfam12867
743722003343	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
743722003344	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722003345	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722003346	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722003347	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003348	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722003349	FecR protein; Region: FecR; pfam04773
743722003350	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722003351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722003352	DNA binding residues [nucleotide binding]
743722003353	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
743722003354	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
743722003355	FAD binding pocket [chemical binding]; other site
743722003356	FAD binding motif [chemical binding]; other site
743722003357	phosphate binding motif [ion binding]; other site
743722003358	NAD binding pocket [chemical binding]; other site
743722003359	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
743722003360	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722003361	Coenzyme A binding pocket [chemical binding]; other site
743722003362	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
743722003363	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722003364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722003365	Predicted amidohydrolase [General function prediction only]; Region: COG0388
743722003366	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_7; cd07585
743722003367	putative active site [active]
743722003368	catalytic triad [active]
743722003369	putative dimer interface [polypeptide binding]; other site
743722003370	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
743722003371	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
743722003372	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
743722003373	RmuC family; Region: RmuC; pfam02646
743722003374	thiamine-monophosphate kinase; Region: thiL; TIGR01379
743722003375	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
743722003376	ATP binding site [chemical binding]; other site
743722003377	dimerization interface [polypeptide binding]; other site
743722003378	quinolinate synthetase; Provisional; Region: PRK09375
743722003379	L-aspartate oxidase; Provisional; Region: PRK06175
743722003380	L-aspartate oxidase; Provisional; Region: PRK09077
743722003381	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
743722003382	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
743722003383	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
743722003384	trimer interface [polypeptide binding]; other site
743722003385	putative metal binding site [ion binding]; other site
743722003386	Bacterial Ig-like domain; Region: Big_5; pfam13205
743722003387	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
743722003388	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722003389	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
743722003390	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
743722003391	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743722003392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722003393	Walker A/P-loop; other site
743722003394	ATP binding site [chemical binding]; other site
743722003395	Q-loop/lid; other site
743722003396	ABC transporter signature motif; other site
743722003397	Walker B; other site
743722003398	D-loop; other site
743722003399	H-loop/switch region; other site
743722003400	ABC transporter; Region: ABC_tran_2; pfam12848
743722003401	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722003402	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
743722003403	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
743722003404	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
743722003405	FMN binding site [chemical binding]; other site
743722003406	active site
743722003407	catalytic residues [active]
743722003408	substrate binding site [chemical binding]; other site
743722003409	CAAX protease self-immunity; Region: Abi; pfam02517
743722003410	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
743722003411	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
743722003412	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
743722003413	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
743722003414	dimer interface [polypeptide binding]; other site
743722003415	motif 1; other site
743722003416	active site
743722003417	motif 2; other site
743722003418	motif 3; other site
743722003419	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
743722003420	anticodon binding site; other site
743722003421	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
743722003422	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
743722003423	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
743722003424	putative DNA binding site [nucleotide binding]; other site
743722003425	putative Zn2+ binding site [ion binding]; other site
743722003426	AsnC family; Region: AsnC_trans_reg; pfam01037
743722003427	pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212
743722003428	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
743722003429	alpha subunit interface [polypeptide binding]; other site
743722003430	TPP binding site [chemical binding]; other site
743722003431	heterodimer interface [polypeptide binding]; other site
743722003432	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722003433	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
743722003434	Part of AAA domain; Region: AAA_19; pfam13245
743722003435	putative recombination protein RecB; Provisional; Region: PRK13909
743722003436	Family description; Region: UvrD_C_2; pfam13538
743722003437	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
743722003438	TM2 domain; Region: TM2; pfam05154
743722003439	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
743722003440	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743722003441	Interdomain contacts; other site
743722003442	Cytokine receptor motif; other site
743722003443	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
743722003444	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722003445	HAMP domain; Region: HAMP; pfam00672
743722003446	dimerization interface [polypeptide binding]; other site
743722003447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722003448	dimer interface [polypeptide binding]; other site
743722003449	phosphorylation site [posttranslational modification]
743722003450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003451	ATP binding site [chemical binding]; other site
743722003452	Mg2+ binding site [ion binding]; other site
743722003453	G-X-G motif; other site
743722003454	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
743722003455	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
743722003456	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
743722003457	homodecamer interface [polypeptide binding]; other site
743722003458	GTP cyclohydrolase I; Provisional; Region: PLN03044
743722003459	active site
743722003460	putative catalytic site residues [active]
743722003461	zinc binding site [ion binding]; other site
743722003462	GTP-CH-I/GFRP interaction surface; other site
743722003463	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
743722003464	active site
743722003465	nucleosidase; Provisional; Region: PRK05634
743722003466	futalosine nucleosidase; Region: fut_nucase; TIGR03664
743722003467	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
743722003468	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
743722003469	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
743722003470	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
743722003471	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
743722003472	active site
743722003473	homotetramer interface [polypeptide binding]; other site
743722003474	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
743722003475	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
743722003476	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
743722003477	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
743722003478	RimM N-terminal domain; Region: RimM; pfam01782
743722003479	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
743722003480	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
743722003481	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
743722003482	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722003483	Zn2+ binding site [ion binding]; other site
743722003484	Mg2+ binding site [ion binding]; other site
743722003485	Cupin domain; Region: Cupin_2; cl17218
743722003486	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
743722003487	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
743722003488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
743722003489	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
743722003490	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722003491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722003492	dimer interface [polypeptide binding]; other site
743722003493	phosphorylation site [posttranslational modification]
743722003494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003495	ATP binding site [chemical binding]; other site
743722003496	Mg2+ binding site [ion binding]; other site
743722003497	G-X-G motif; other site
743722003498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722003499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722003500	active site
743722003501	phosphorylation site [posttranslational modification]
743722003502	intermolecular recognition site; other site
743722003503	dimerization interface [polypeptide binding]; other site
743722003504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722003505	DNA binding site [nucleotide binding]
743722003506	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
743722003507	aldehyde dehydrogenase family 7 member; Region: PLN02315
743722003508	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
743722003509	tetrameric interface [polypeptide binding]; other site
743722003510	NAD binding site [chemical binding]; other site
743722003511	catalytic residues [active]
743722003512	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003513	TPR repeat; Region: TPR_11; pfam13414
743722003514	binding surface
743722003515	TPR motif; other site
743722003516	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003517	binding surface
743722003518	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722003519	TPR motif; other site
743722003520	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003521	binding surface
743722003522	TPR repeat; Region: TPR_11; pfam13414
743722003523	TPR motif; other site
743722003524	TPR repeat; Region: TPR_11; pfam13414
743722003525	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722003526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003527	binding surface
743722003528	TPR motif; other site
743722003529	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003530	binding surface
743722003531	TPR motif; other site
743722003532	TPR repeat; Region: TPR_11; pfam13414
743722003533	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
743722003534	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
743722003535	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
743722003536	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
743722003537	shikimate binding site; other site
743722003538	NAD(P) binding site [chemical binding]; other site
743722003539	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
743722003540	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
743722003541	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
743722003542	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722003543	FtsX-like permease family; Region: FtsX; pfam02687
743722003544	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
743722003545	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
743722003546	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722003547	ATP binding site [chemical binding]; other site
743722003548	putative Mg++ binding site [ion binding]; other site
743722003549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722003550	nucleotide binding region [chemical binding]; other site
743722003551	ATP-binding site [chemical binding]; other site
743722003552	TRCF domain; Region: TRCF; pfam03461
743722003553	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
743722003554	Predicted flavoprotein [General function prediction only]; Region: COG0431
743722003555	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722003556	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
743722003557	Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; Region: SLC5sbd_vSGLT; cd10325
743722003558	Na binding site [ion binding]; other site
743722003559	substrate binding site [chemical binding]; other site
743722003560	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
743722003561	active site
743722003562	catalytic residues [active]
743722003563	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
743722003564	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
743722003565	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
743722003566	Predicted transcriptional regulators [Transcription]; Region: COG1695
743722003567	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
743722003568	PspC domain; Region: PspC; pfam04024
743722003569	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
743722003570	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743722003571	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722003572	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
743722003573	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
743722003574	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
743722003575	domain interfaces; other site
743722003576	active site
743722003577	acyl carrier protein; Provisional; Region: acpP; PRK00982
743722003578	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
743722003579	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
743722003580	dimer interface [polypeptide binding]; other site
743722003581	active site
743722003582	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
743722003583	dimerization interface [polypeptide binding]; other site
743722003584	active site
743722003585	metal binding site [ion binding]; metal-binding site
743722003586	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
743722003587	recombination factor protein RarA; Reviewed; Region: PRK13342
743722003588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722003589	Walker A motif; other site
743722003590	ATP binding site [chemical binding]; other site
743722003591	Walker B motif; other site
743722003592	arginine finger; other site
743722003593	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
743722003594	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722003595	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722003596	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722003597	binding surface
743722003598	TPR motif; other site
743722003599	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722003600	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722003601	carboxy-terminal protease; Provisional; Region: PRK11186
743722003602	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
743722003603	protein binding site [polypeptide binding]; other site
743722003604	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
743722003605	Catalytic dyad [active]
743722003606	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
743722003607	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
743722003608	FMN binding site [chemical binding]; other site
743722003609	dimer interface [polypeptide binding]; other site
743722003610	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
743722003611	NifU-like domain; Region: NifU; cl00484
743722003612	antiporter inner membrane protein; Provisional; Region: PRK11670
743722003613	Domain of unknown function DUF59; Region: DUF59; pfam01883
743722003614	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
743722003615	Transglycosylase; Region: Transgly; pfam00912
743722003616	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722003617	active site
743722003618	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
743722003619	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722003620	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722003621	dimer interface [polypeptide binding]; other site
743722003622	phosphorylation site [posttranslational modification]
743722003623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003624	ATP binding site [chemical binding]; other site
743722003625	Mg2+ binding site [ion binding]; other site
743722003626	G-X-G motif; other site
743722003627	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
743722003628	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
743722003629	Gram-negative bacterial tonB protein; Region: TonB; cl10048
743722003630	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722003631	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722003632	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722003633	DNA binding residues [nucleotide binding]
743722003634	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
743722003635	Uncharacterized conserved protein [Function unknown]; Region: COG0327
743722003636	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
743722003637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
743722003638	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
743722003639	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
743722003640	Putative zinc ribbon domain; Region: DUF164; pfam02591
743722003641	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
743722003642	peptidase T; Region: peptidase-T; TIGR01882
743722003643	metal binding site [ion binding]; metal-binding site
743722003644	dimer interface [polypeptide binding]; other site
743722003645	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
743722003646	putative active site [active]
743722003647	dimerization interface [polypeptide binding]; other site
743722003648	putative tRNAtyr binding site [nucleotide binding]; other site
743722003649	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
743722003650	homodimer interface [polypeptide binding]; other site
743722003651	metal binding site [ion binding]; metal-binding site
743722003652	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
743722003653	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
743722003654	ATP binding site [chemical binding]; other site
743722003655	substrate interface [chemical binding]; other site
743722003656	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722003657	active site residue [active]
743722003658	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
743722003659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722003660	FeS/SAM binding site; other site
743722003661	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
743722003662	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
743722003663	ThiS interaction site; other site
743722003664	putative active site [active]
743722003665	tetramer interface [polypeptide binding]; other site
743722003666	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
743722003667	active site
743722003668	thiamine phosphate binding site [chemical binding]; other site
743722003669	pyrophosphate binding site [ion binding]; other site
743722003670	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
743722003671	thiamine phosphate binding site [chemical binding]; other site
743722003672	active site
743722003673	pyrophosphate binding site [ion binding]; other site
743722003674	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
743722003675	ThiC-associated domain; Region: ThiC-associated; pfam13667
743722003676	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
743722003677	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
743722003678	thiS-thiF/thiG interaction site; other site
743722003679	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
743722003680	SnoaL-like domain; Region: SnoaL_3; pfam13474
743722003681	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
743722003682	putative active site [active]
743722003683	putative catalytic site [active]
743722003684	putative DNA binding site [nucleotide binding]; other site
743722003685	putative phosphate binding site [ion binding]; other site
743722003686	metal binding site A [ion binding]; metal-binding site
743722003687	putative AP binding site [nucleotide binding]; other site
743722003688	putative metal binding site B [ion binding]; other site
743722003689	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
743722003690	active site
743722003691	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
743722003692	heme-binding site [chemical binding]; other site
743722003693	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722003694	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
743722003695	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722003696	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
743722003697	protein binding site [polypeptide binding]; other site
743722003698	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
743722003699	Catalytic dyad [active]
743722003700	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722003701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722003702	active site
743722003703	phosphorylation site [posttranslational modification]
743722003704	intermolecular recognition site; other site
743722003705	dimerization interface [polypeptide binding]; other site
743722003706	LytTr DNA-binding domain; Region: LytTR; smart00850
743722003707	Histidine kinase; Region: His_kinase; pfam06580
743722003708	Penicillinase repressor; Region: Pencillinase_R; pfam03965
743722003709	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
743722003710	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
743722003711	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
743722003712	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
743722003713	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
743722003714	L-aspartate oxidase; Provisional; Region: PRK06175
743722003715	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
743722003716	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
743722003717	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
743722003718	putative Iron-sulfur protein interface [polypeptide binding]; other site
743722003719	proximal heme binding site [chemical binding]; other site
743722003720	distal heme binding site [chemical binding]; other site
743722003721	putative dimer interface [polypeptide binding]; other site
743722003722	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
743722003723	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743722003724	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
743722003725	protein binding site [polypeptide binding]; other site
743722003726	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
743722003727	protein binding site [polypeptide binding]; other site
743722003728	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
743722003729	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
743722003730	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
743722003731	SurA N-terminal domain; Region: SurA_N_3; cl07813
743722003732	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
743722003733	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
743722003734	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
743722003735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200
743722003736	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
743722003737	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722003738	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
743722003739	putative active site [active]
743722003740	putative metal binding site [ion binding]; other site
743722003741	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
743722003742	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722003743	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722003744	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
743722003745	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
743722003746	active site residue [active]
743722003747	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743722003748	Interdomain contacts; other site
743722003749	Cytokine receptor motif; other site
743722003750	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722003751	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
743722003752	DNA binding residues [nucleotide binding]
743722003753	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722003754	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003755	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722003756	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722003757	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722003758	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
743722003759	Putative glucoamylase; Region: Glycoamylase; pfam10091
743722003760	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722003761	active site
743722003762	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722003763	sugar binding site [chemical binding]; other site
743722003764	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
743722003765	Interdomain contacts; other site
743722003766	Cytokine receptor motif; other site
743722003767	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
743722003768	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
743722003769	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
743722003770	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
743722003771	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
743722003772	Predicted membrane protein [Function unknown]; Region: COG2259
743722003773	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
743722003774	dimer interface [polypeptide binding]; other site
743722003775	catalytic triad [active]
743722003776	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
743722003777	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
743722003778	active site
743722003779	HIGH motif; other site
743722003780	KMSKS motif; other site
743722003781	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
743722003782	tRNA binding surface [nucleotide binding]; other site
743722003783	anticodon binding site; other site
743722003784	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
743722003785	dimer interface [polypeptide binding]; other site
743722003786	putative tRNA-binding site [nucleotide binding]; other site
743722003787	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
743722003788	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
743722003789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722003790	catalytic residue [active]
743722003791	homoserine kinase; Provisional; Region: PRK01212
743722003792	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
743722003793	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
743722003794	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
743722003795	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
743722003796	putative catalytic residues [active]
743722003797	nucleotide binding site [chemical binding]; other site
743722003798	aspartate binding site [chemical binding]; other site
743722003799	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
743722003800	dimer interface [polypeptide binding]; other site
743722003801	putative threonine allosteric regulatory site; other site
743722003802	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
743722003803	putative threonine allosteric regulatory site; other site
743722003804	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
743722003805	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
743722003806	ribosome recycling factor; Reviewed; Region: frr; PRK00083
743722003807	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
743722003808	hinge region; other site
743722003809	GTPase RsgA; Reviewed; Region: PRK00098
743722003810	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
743722003811	RNA binding site [nucleotide binding]; other site
743722003812	homodimer interface [polypeptide binding]; other site
743722003813	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
743722003814	GTPase/Zn-binding domain interface [polypeptide binding]; other site
743722003815	GTP/Mg2+ binding site [chemical binding]; other site
743722003816	G4 box; other site
743722003817	G5 box; other site
743722003818	G1 box; other site
743722003819	Switch I region; other site
743722003820	G2 box; other site
743722003821	G3 box; other site
743722003822	Switch II region; other site
743722003823	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
743722003824	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
743722003825	HIGH motif; other site
743722003826	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
743722003827	active site
743722003828	KMSKS motif; other site
743722003829	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722003830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
743722003831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003832	ATP binding site [chemical binding]; other site
743722003833	Mg2+ binding site [ion binding]; other site
743722003834	G-X-G motif; other site
743722003835	DinB superfamily; Region: DinB_2; pfam12867
743722003836	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
743722003837	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722003838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722003839	putative substrate translocation pore; other site
743722003840	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
743722003841	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
743722003842	signal recognition particle protein; Provisional; Region: PRK10867
743722003843	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
743722003844	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
743722003845	P loop; other site
743722003846	GTP binding site [chemical binding]; other site
743722003847	Signal peptide binding domain; Region: SRP_SPB; pfam02978
743722003848	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
743722003849	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
743722003850	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722003851	Walker A motif; other site
743722003852	ATP binding site [chemical binding]; other site
743722003853	Walker B motif; other site
743722003854	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
743722003855	elongation factor Ts; Provisional; Region: tsf; PRK09377
743722003856	UBA/TS-N domain; Region: UBA; pfam00627
743722003857	Elongation factor TS; Region: EF_TS; pfam00889
743722003858	Elongation factor TS; Region: EF_TS; pfam00889
743722003859	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
743722003860	rRNA interaction site [nucleotide binding]; other site
743722003861	S8 interaction site; other site
743722003862	putative laminin-1 binding site; other site
743722003863	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
743722003864	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
743722003865	23S rRNA interface [nucleotide binding]; other site
743722003866	L3 interface [polypeptide binding]; other site
743722003867	multidrug efflux protein; Reviewed; Region: PRK01766
743722003868	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
743722003869	cation binding site [ion binding]; other site
743722003870	peptide chain release factor 1; Validated; Region: prfA; PRK00591
743722003871	This domain is found in peptide chain release factors; Region: PCRF; smart00937
743722003872	RF-1 domain; Region: RF-1; pfam00472
743722003873	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722003874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722003875	putative substrate translocation pore; other site
743722003876	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722003877	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
743722003878	putative active site [active]
743722003879	putative metal binding site [ion binding]; other site
743722003880	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722003881	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722003882	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722003883	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
743722003884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722003885	TraB family; Region: TraB; pfam01963
743722003886	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
743722003887	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
743722003888	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
743722003889	generic binding surface II; other site
743722003890	generic binding surface I; other site
743722003891	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722003892	DinB superfamily; Region: DinB_2; pfam12867
743722003893	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
743722003894	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
743722003895	substrate-cofactor binding pocket; other site
743722003896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722003897	catalytic residue [active]
743722003898	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
743722003899	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
743722003900	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
743722003901	dimer interface [polypeptide binding]; other site
743722003902	motif 1; other site
743722003903	active site
743722003904	motif 2; other site
743722003905	motif 3; other site
743722003906	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
743722003907	iron-sulfur cluster [ion binding]; other site
743722003908	[2Fe-2S] cluster binding site [ion binding]; other site
743722003909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722003910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722003911	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
743722003912	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
743722003913	Na binding site [ion binding]; other site
743722003914	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
743722003915	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743722003916	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
743722003917	active site
743722003918	dimerization interface [polypeptide binding]; other site
743722003919	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
743722003920	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
743722003921	active site
743722003922	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722003923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722003924	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722003925	SurA N-terminal domain; Region: SurA_N_3; cl07813
743722003926	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
743722003927	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
743722003928	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
743722003929	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
743722003930	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722003931	active site
743722003932	HIGH motif; other site
743722003933	nucleotide binding site [chemical binding]; other site
743722003934	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
743722003935	KMSKS motif; other site
743722003936	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
743722003937	tRNA binding surface [nucleotide binding]; other site
743722003938	anticodon binding site; other site
743722003939	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
743722003940	putative catalytic site [active]
743722003941	putative metal binding site [ion binding]; other site
743722003942	putative phosphate binding site [ion binding]; other site
743722003943	Rhomboid family; Region: Rhomboid; cl11446
743722003944	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
743722003945	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
743722003946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722003947	ATP binding site [chemical binding]; other site
743722003948	Mg2+ binding site [ion binding]; other site
743722003949	G-X-G motif; other site
743722003950	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
743722003951	ATP binding site [chemical binding]; other site
743722003952	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
743722003953	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
743722003954	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
743722003955	tetramer interface [polypeptide binding]; other site
743722003956	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722003957	catalytic residue [active]
743722003958	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722003959	catalytic residues [active]
743722003960	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
743722003961	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
743722003962	dimer interface [polypeptide binding]; other site
743722003963	decamer (pentamer of dimers) interface [polypeptide binding]; other site
743722003964	catalytic triad [active]
743722003965	peroxidatic and resolving cysteines [active]
743722003966	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
743722003967	GIY-YIG motif/motif A; other site
743722003968	putative active site [active]
743722003969	putative metal binding site [ion binding]; other site
743722003970	short chain dehydrogenase; Provisional; Region: PRK08263
743722003971	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722003972	NADP binding site [chemical binding]; other site
743722003973	active site
743722003974	steroid binding site; other site
743722003975	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722003976	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722003977	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722003978	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
743722003979	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722003980	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
743722003981	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
743722003982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722003983	S-adenosylmethionine binding site [chemical binding]; other site
743722003984	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743722003985	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722003986	DNA-binding site [nucleotide binding]; DNA binding site
743722003987	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722003988	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722003989	homodimer interface [polypeptide binding]; other site
743722003990	catalytic residue [active]
743722003991	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722003992	Coenzyme A binding pocket [chemical binding]; other site
743722003993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722003994	Coenzyme A binding pocket [chemical binding]; other site
743722003995	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722003996	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
743722003997	DinB superfamily; Region: DinB_2; pfam12867
743722003998	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
743722003999	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743722004000	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
743722004001	DNA binding site [nucleotide binding]
743722004002	active site
743722004003	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
743722004004	putative SAM binding site [chemical binding]; other site
743722004005	homodimer interface [polypeptide binding]; other site
743722004006	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
743722004007	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
743722004008	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
743722004009	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
743722004010	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743722004011	substrate binding site [chemical binding]; other site
743722004012	oxyanion hole (OAH) forming residues; other site
743722004013	trimer interface [polypeptide binding]; other site
743722004014	short chain dehydrogenase; Provisional; Region: PRK07677
743722004015	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
743722004016	NAD(P) binding site [chemical binding]; other site
743722004017	substrate binding site [chemical binding]; other site
743722004018	homotetramer interface [polypeptide binding]; other site
743722004019	active site
743722004020	homodimer interface [polypeptide binding]; other site
743722004021	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
743722004022	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
743722004023	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722004024	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722004025	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722004026	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
743722004027	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
743722004028	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
743722004029	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
743722004030	Glutamine amidotransferase class-I; Region: GATase; pfam00117
743722004031	glutamine binding [chemical binding]; other site
743722004032	catalytic triad [active]
743722004033	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
743722004034	active site
743722004035	ribulose/triose binding site [chemical binding]; other site
743722004036	phosphate binding site [ion binding]; other site
743722004037	substrate (anthranilate) binding pocket [chemical binding]; other site
743722004038	product (indole) binding pocket [chemical binding]; other site
743722004039	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
743722004040	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
743722004041	active site
743722004042	trimer interface [polypeptide binding]; other site
743722004043	allosteric site; other site
743722004044	active site lid [active]
743722004045	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743722004046	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
743722004047	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
743722004048	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
743722004049	active site
743722004050	(T/H)XGH motif; other site
743722004051	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
743722004052	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
743722004053	catalytic site [active]
743722004054	G-X2-G-X-G-K; other site
743722004055	hypothetical protein; Provisional; Region: PRK11820
743722004056	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
743722004057	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
743722004058	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722004059	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722004060	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722004061	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722004062	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722004063	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722004064	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722004065	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722004066	ligand binding site [chemical binding]; other site
743722004067	DNA polymerase I; Provisional; Region: PRK05755
743722004068	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
743722004069	active site
743722004070	metal binding site 1 [ion binding]; metal-binding site
743722004071	putative 5' ssDNA interaction site; other site
743722004072	metal binding site 3; metal-binding site
743722004073	metal binding site 2 [ion binding]; metal-binding site
743722004074	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
743722004075	putative DNA binding site [nucleotide binding]; other site
743722004076	putative metal binding site [ion binding]; other site
743722004077	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
743722004078	active site
743722004079	catalytic site [active]
743722004080	substrate binding site [chemical binding]; other site
743722004081	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
743722004082	active site
743722004083	DNA binding site [nucleotide binding]
743722004084	catalytic site [active]
743722004085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
743722004086	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743722004087	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
743722004088	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
743722004089	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743722004090	Beta-lactamase; Region: Beta-lactamase; pfam00144
743722004091	fumarate hydratase; Reviewed; Region: fumC; PRK00485
743722004092	Class II fumarases; Region: Fumarase_classII; cd01362
743722004093	active site
743722004094	tetramer interface [polypeptide binding]; other site
743722004095	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722004096	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722004097	S-adenosylmethionine binding site [chemical binding]; other site
743722004098	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
743722004099	putative active site [active]
743722004100	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
743722004101	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743722004102	Interdomain contacts; other site
743722004103	Cytokine receptor motif; other site
743722004104	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
743722004105	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
743722004106	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
743722004107	tetramer interface [polypeptide binding]; other site
743722004108	heme binding pocket [chemical binding]; other site
743722004109	NADPH binding site [chemical binding]; other site
743722004110	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
743722004111	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722004112	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
743722004113	dimerization interface [polypeptide binding]; other site
743722004114	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
743722004115	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
743722004116	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
743722004117	hexamer interface [polypeptide binding]; other site
743722004118	ligand binding site [chemical binding]; other site
743722004119	putative active site [active]
743722004120	NAD(P) binding site [chemical binding]; other site
743722004121	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
743722004122	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
743722004123	Response regulator receiver domain; Region: Response_reg; pfam00072
743722004124	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722004125	active site
743722004126	phosphorylation site [posttranslational modification]
743722004127	intermolecular recognition site; other site
743722004128	dimerization interface [polypeptide binding]; other site
743722004129	PglZ domain; Region: PglZ; pfam08665
743722004130	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
743722004131	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722004132	Zn2+ binding site [ion binding]; other site
743722004133	Mg2+ binding site [ion binding]; other site
743722004134	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
743722004135	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
743722004136	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
743722004137	trimer interface [polypeptide binding]; other site
743722004138	active site
743722004139	UDP-GlcNAc binding site [chemical binding]; other site
743722004140	lipid binding site [chemical binding]; lipid-binding site
743722004141	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
743722004142	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
743722004143	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
743722004144	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
743722004145	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
743722004146	active site
743722004147	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
743722004148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722004149	Walker A/P-loop; other site
743722004150	ATP binding site [chemical binding]; other site
743722004151	Q-loop/lid; other site
743722004152	ABC transporter signature motif; other site
743722004153	Walker B; other site
743722004154	D-loop; other site
743722004155	H-loop/switch region; other site
743722004156	elongation factor P; Validated; Region: PRK00529
743722004157	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
743722004158	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
743722004159	RNA binding site [nucleotide binding]; other site
743722004160	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
743722004161	RNA binding site [nucleotide binding]; other site
743722004162	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
743722004163	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
743722004164	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
743722004165	active site
743722004166	Zn binding site [ion binding]; other site
743722004167	deoxyhypusine synthase; Region: dhys; TIGR00321
743722004168	Deoxyhypusine synthase; Region: DS; cl00826
743722004169	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
743722004170	Cytochrome c; Region: Cytochrom_C; pfam00034
743722004171	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
743722004172	heme-binding residues [chemical binding]; other site
743722004173	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
743722004174	molybdopterin cofactor binding site; other site
743722004175	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
743722004176	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
743722004177	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
743722004178	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
743722004179	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
743722004180	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
743722004181	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
743722004182	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
743722004183	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
743722004184	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
743722004185	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
743722004186	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
743722004187	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
743722004188	protoheme IX farnesyltransferase; Region: cyoE_ctaB; TIGR01473
743722004189	UbiA prenyltransferase family; Region: UbiA; pfam01040
743722004190	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
743722004191	Subunit I/III interface [polypeptide binding]; other site
743722004192	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
743722004193	Subunit I/III interface [polypeptide binding]; other site
743722004194	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
743722004195	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
743722004196	Protein of unknown function (DUF420); Region: DUF420; pfam04238
743722004197	Protein of unknown function (DUF983); Region: DUF983; cl02211
743722004198	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722004199	ligand binding site [chemical binding]; other site
743722004200	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
743722004201	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
743722004202	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743722004203	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722004204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722004205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722004206	dimer interface [polypeptide binding]; other site
743722004207	phosphorylation site [posttranslational modification]
743722004208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722004209	ATP binding site [chemical binding]; other site
743722004210	Mg2+ binding site [ion binding]; other site
743722004211	G-X-G motif; other site
743722004212	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722004213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722004214	active site
743722004215	phosphorylation site [posttranslational modification]
743722004216	intermolecular recognition site; other site
743722004217	dimerization interface [polypeptide binding]; other site
743722004218	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722004219	DNA binding site [nucleotide binding]
743722004220	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
743722004221	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
743722004222	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
743722004223	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
743722004224	nucleotide binding site/active site [active]
743722004225	HIT family signature motif; other site
743722004226	catalytic residue [active]
743722004227	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
743722004228	active site
743722004229	putative DNA-binding cleft [nucleotide binding]; other site
743722004230	dimer interface [polypeptide binding]; other site
743722004231	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
743722004232	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722004233	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192
743722004234	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743722004235	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
743722004236	putative acyl-acceptor binding pocket; other site
743722004237	S-adenosylmethionine synthetase; Validated; Region: PRK05250
743722004238	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
743722004239	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
743722004240	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
743722004241	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
743722004242	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
743722004243	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
743722004244	putative rRNA binding site [nucleotide binding]; other site
743722004245	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
743722004246	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
743722004247	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
743722004248	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
743722004249	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
743722004250	PBP superfamily domain; Region: PBP_like_2; pfam12849
743722004251	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722004252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722004253	TPR motif; other site
743722004254	binding surface
743722004255	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722004256	TPR motif; other site
743722004257	binding surface
743722004258	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
743722004259	NADH dehydrogenase subunit B; Provisional; Region: PRK14820
743722004260	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
743722004261	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
743722004262	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
743722004263	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
743722004264	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
743722004265	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
743722004266	putative dimer interface [polypeptide binding]; other site
743722004267	[2Fe-2S] cluster binding site [ion binding]; other site
743722004268	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
743722004269	SLBB domain; Region: SLBB; pfam10531
743722004270	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
743722004271	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722004272	catalytic loop [active]
743722004273	iron binding site [ion binding]; other site
743722004274	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
743722004275	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
743722004276	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
743722004277	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
743722004278	4Fe-4S binding domain; Region: Fer4; pfam00037
743722004279	4Fe-4S binding domain; Region: Fer4; pfam00037
743722004280	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
743722004281	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
743722004282	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
743722004283	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
743722004284	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
743722004285	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722004286	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
743722004287	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722004288	proton-translocating NADH-quinone oxidoreductase, chain N; Region: NDH_I_N; TIGR01770
743722004289	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722004290	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743722004291	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
743722004292	inorganic pyrophosphatase; Provisional; Region: PRK02230
743722004293	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
743722004294	dimer interface [polypeptide binding]; other site
743722004295	substrate binding site [chemical binding]; other site
743722004296	metal binding sites [ion binding]; metal-binding site
743722004297	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
743722004298	Domain of unknown function DUF21; Region: DUF21; pfam01595
743722004299	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743722004300	Transporter associated domain; Region: CorC_HlyC; smart01091
743722004301	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
743722004302	RNA methyltransferase, RsmE family; Region: TIGR00046
743722004303	prephenate dehydrogenase; Validated; Region: PRK08507
743722004304	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
743722004305	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
743722004306	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722004307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722004308	homodimer interface [polypeptide binding]; other site
743722004309	catalytic residue [active]
743722004310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722004311	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722004312	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
743722004313	Walker A/P-loop; other site
743722004314	ATP binding site [chemical binding]; other site
743722004315	Q-loop/lid; other site
743722004316	ABC transporter signature motif; other site
743722004317	Walker B; other site
743722004318	D-loop; other site
743722004319	H-loop/switch region; other site
743722004320	translation initiation factor IF-2; Region: IF-2; TIGR00487
743722004321	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
743722004322	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
743722004323	G1 box; other site
743722004324	putative GEF interaction site [polypeptide binding]; other site
743722004325	GTP/Mg2+ binding site [chemical binding]; other site
743722004326	Switch I region; other site
743722004327	G2 box; other site
743722004328	G3 box; other site
743722004329	Switch II region; other site
743722004330	G4 box; other site
743722004331	G5 box; other site
743722004332	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
743722004333	Translation-initiation factor 2; Region: IF-2; pfam11987
743722004334	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
743722004335	transcription termination factor NusA; Region: NusA; TIGR01953
743722004336	NusA N-terminal domain; Region: NusA_N; pfam08529
743722004337	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
743722004338	RNA binding site [nucleotide binding]; other site
743722004339	homodimer interface [polypeptide binding]; other site
743722004340	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
743722004341	G-X-X-G motif; other site
743722004342	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
743722004343	G-X-X-G motif; other site
743722004344	ribosome maturation protein RimP; Reviewed; Region: PRK00092
743722004345	Sm and related proteins; Region: Sm_like; cl00259
743722004346	heptamer interface [polypeptide binding]; other site
743722004347	Sm1 motif; other site
743722004348	hexamer interface [polypeptide binding]; other site
743722004349	RNA binding site [nucleotide binding]; other site
743722004350	Sm2 motif; other site
743722004351	Membrane protein of unknown function; Region: DUF360; pfam04020
743722004352	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
743722004353	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
743722004354	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
743722004355	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743722004356	Beta-lactamase; Region: Beta-lactamase; cl17358
743722004357	OstA-like protein; Region: OstA_2; pfam13100
743722004358	Peptidase S46; Region: Peptidase_S46; pfam10459
743722004359	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743722004360	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
743722004361	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
743722004362	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722004363	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722004364	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722004365	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
743722004366	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
743722004367	Ligand Binding Site [chemical binding]; other site
743722004368	TilS substrate C-terminal domain; Region: TilS_C; smart00977
743722004369	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
743722004370	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
743722004371	metal-binding site
743722004372	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004373	active site
743722004374	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722004375	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004376	active site
743722004377	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004378	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722004379	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722004380	Methyltransferase domain; Region: Methyltransf_24; pfam13578
743722004381	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
743722004382	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
743722004383	G1 box; other site
743722004384	putative GEF interaction site [polypeptide binding]; other site
743722004385	GTP/Mg2+ binding site [chemical binding]; other site
743722004386	Switch I region; other site
743722004387	G2 box; other site
743722004388	G3 box; other site
743722004389	Switch II region; other site
743722004390	G4 box; other site
743722004391	G5 box; other site
743722004392	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
743722004393	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
743722004394	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
743722004395	homotrimer interaction site [polypeptide binding]; other site
743722004396	zinc binding site [ion binding]; other site
743722004397	CDP-binding sites; other site
743722004398	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
743722004399	gliding motility-associated lipoprotein GldJ; Region: GldJ_short; TIGR03530
743722004400	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
743722004401	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
743722004402	pantoate--beta-alanine ligase; Region: panC; TIGR00018
743722004403	Pantoate-beta-alanine ligase; Region: PanC; cd00560
743722004404	active site
743722004405	ATP-binding site [chemical binding]; other site
743722004406	pantoate-binding site; other site
743722004407	HXXH motif; other site
743722004408	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
743722004409	tetramerization interface [polypeptide binding]; other site
743722004410	active site
743722004411	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722004412	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722004413	active site
743722004414	phosphorylation site [posttranslational modification]
743722004415	intermolecular recognition site; other site
743722004416	dimerization interface [polypeptide binding]; other site
743722004417	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722004418	DNA binding site [nucleotide binding]
743722004419	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722004420	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743722004421	dimerization interface [polypeptide binding]; other site
743722004422	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722004423	dimer interface [polypeptide binding]; other site
743722004424	phosphorylation site [posttranslational modification]
743722004425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722004426	ATP binding site [chemical binding]; other site
743722004427	Mg2+ binding site [ion binding]; other site
743722004428	G-X-G motif; other site
743722004429	PIF1-like helicase; Region: PIF1; pfam05970
743722004430	AAA domain; Region: AAA_30; pfam13604
743722004431	Family description; Region: UvrD_C_2; pfam13538
743722004432	Peptidase family M1; Region: Peptidase_M1; pfam01433
743722004433	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
743722004434	Zn binding site [ion binding]; other site
743722004435	HEAT repeats; Region: HEAT_2; pfam13646
743722004436	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722004437	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722004438	catalytic residues [active]
743722004439	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743722004440	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
743722004441	FAD binding site [chemical binding]; other site
743722004442	homotetramer interface [polypeptide binding]; other site
743722004443	substrate binding pocket [chemical binding]; other site
743722004444	catalytic base [active]
743722004445	Cupin domain; Region: Cupin_2; cl17218
743722004446	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
743722004447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722004448	ATP binding site [chemical binding]; other site
743722004449	Mg2+ binding site [ion binding]; other site
743722004450	G-X-G motif; other site
743722004451	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
743722004452	anchoring element; other site
743722004453	dimer interface [polypeptide binding]; other site
743722004454	ATP binding site [chemical binding]; other site
743722004455	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
743722004456	active site
743722004457	putative metal-binding site [ion binding]; other site
743722004458	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
743722004459	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
743722004460	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
743722004461	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
743722004462	putative active site [active]
743722004463	putative substrate binding site [chemical binding]; other site
743722004464	putative cosubstrate binding site; other site
743722004465	catalytic site [active]
743722004466	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722004467	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722004468	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722004469	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722004470	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722004471	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722004472	SusD family; Region: SusD; pfam07980
743722004473	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
743722004474	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722004475	active site
743722004476	catalytic tetrad [active]
743722004477	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722004478	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
743722004479	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
743722004480	PA/protease or protease-like domain interface [polypeptide binding]; other site
743722004481	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
743722004482	metal binding site [ion binding]; metal-binding site
743722004483	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722004484	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722004485	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722004486	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722004487	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722004488	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722004489	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
743722004490	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
743722004491	CAP-like domain; other site
743722004492	active site
743722004493	primary dimer interface [polypeptide binding]; other site
743722004494	methionine sulfoxide reductase A; Provisional; Region: PRK14054
743722004495	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
743722004496	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722004497	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722004498	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722004499	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722004500	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722004501	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722004502	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722004503	SusD family; Region: SusD; pfam07980
743722004504	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722004505	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722004506	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722004507	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722004508	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722004509	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722004510	FecR protein; Region: FecR; pfam04773
743722004511	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722004512	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722004513	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722004514	DNA binding residues [nucleotide binding]
743722004515	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
743722004516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722004517	S-adenosylmethionine binding site [chemical binding]; other site
743722004518	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
743722004519	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722004520	Walker A/P-loop; other site
743722004521	ATP binding site [chemical binding]; other site
743722004522	Q-loop/lid; other site
743722004523	ABC transporter signature motif; other site
743722004524	Walker B; other site
743722004525	D-loop; other site
743722004526	H-loop/switch region; other site
743722004527	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
743722004528	Permease; Region: Permease; pfam02405
743722004529	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
743722004530	classical (c) SDRs; Region: SDR_c; cd05233
743722004531	NAD(P) binding site [chemical binding]; other site
743722004532	active site
743722004533	PspC domain; Region: PspC; pfam04024
743722004534	RDD family; Region: RDD; pfam06271
743722004535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722004536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722004537	Outer membrane efflux protein; Region: OEP; pfam02321
743722004538	Outer membrane efflux protein; Region: OEP; pfam02321
743722004539	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
743722004540	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722004541	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722004542	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
743722004543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722004544	putative substrate translocation pore; other site
743722004545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722004546	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722004547	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722004548	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722004549	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722004550	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722004551	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
743722004552	DNA photolyase; Region: DNA_photolyase; pfam00875
743722004553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722004554	TIGR01777 family protein; Region: yfcH
743722004555	NAD(P) binding site [chemical binding]; other site
743722004556	active site
743722004557	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
743722004558	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722004559	NAD(P) binding site [chemical binding]; other site
743722004560	active site
743722004561	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
743722004562	DNA photolyase; Region: DNA_photolyase; pfam00875
743722004563	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
743722004564	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
743722004565	TPP-binding site [chemical binding]; other site
743722004566	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
743722004567	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722004568	E3 interaction surface; other site
743722004569	lipoyl attachment site [posttranslational modification]; other site
743722004570	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
743722004571	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722004572	E3 interaction surface; other site
743722004573	lipoyl attachment site [posttranslational modification]; other site
743722004574	e3 binding domain; Region: E3_binding; pfam02817
743722004575	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743722004576	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
743722004577	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
743722004578	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
743722004579	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
743722004580	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722004581	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
743722004582	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
743722004583	Sulfatase; Region: Sulfatase; pfam00884
743722004584	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722004585	Sulfatase; Region: Sulfatase; pfam00884
743722004586	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
743722004587	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722004588	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743722004589	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722004590	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722004591	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722004592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722004593	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722004594	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722004595	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
743722004596	FAD binding domain; Region: FAD_binding_4; pfam01565
743722004597	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
743722004598	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
743722004599	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722004600	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722004601	DNA binding residues [nucleotide binding]
743722004602	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
743722004603	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743722004604	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743722004605	substrate binding site [chemical binding]; other site
743722004606	ATP binding site [chemical binding]; other site
743722004607	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
743722004608	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722004609	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722004610	glycyl-tRNA synthetase; Provisional; Region: PRK04173
743722004611	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
743722004612	motif 1; other site
743722004613	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
743722004614	active site
743722004615	motif 2; other site
743722004616	motif 3; other site
743722004617	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
743722004618	anticodon binding site; other site
743722004619	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743722004620	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
743722004621	putative active site [active]
743722004622	catalytic site [active]
743722004623	putative metal binding site [ion binding]; other site
743722004624	oligomer interface [polypeptide binding]; other site
743722004625	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
743722004626	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722004627	Walker A/P-loop; other site
743722004628	ATP binding site [chemical binding]; other site
743722004629	Q-loop/lid; other site
743722004630	ABC transporter signature motif; other site
743722004631	Walker B; other site
743722004632	D-loop; other site
743722004633	H-loop/switch region; other site
743722004634	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
743722004635	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
743722004636	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
743722004637	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
743722004638	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
743722004639	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
743722004640	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722004641	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722004642	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722004643	DNA polymerase III subunit beta; Validated; Region: PRK05643
743722004644	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
743722004645	putative DNA binding surface [nucleotide binding]; other site
743722004646	dimer interface [polypeptide binding]; other site
743722004647	beta-clamp/clamp loader binding surface; other site
743722004648	beta-clamp/translesion DNA polymerase binding surface; other site
743722004649	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
743722004650	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743722004651	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
743722004652	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
743722004653	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
743722004654	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
743722004655	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
743722004656	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
743722004657	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
743722004658	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
743722004659	putative translocon binding site; other site
743722004660	protein-rRNA interface [nucleotide binding]; other site
743722004661	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
743722004662	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
743722004663	G-X-X-G motif; other site
743722004664	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
743722004665	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
743722004666	23S rRNA interface [nucleotide binding]; other site
743722004667	5S rRNA interface [nucleotide binding]; other site
743722004668	putative antibiotic binding site [chemical binding]; other site
743722004669	L25 interface [polypeptide binding]; other site
743722004670	L27 interface [polypeptide binding]; other site
743722004671	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
743722004672	putative translocon interaction site; other site
743722004673	23S rRNA interface [nucleotide binding]; other site
743722004674	signal recognition particle (SRP54) interaction site; other site
743722004675	L23 interface [polypeptide binding]; other site
743722004676	trigger factor interaction site; other site
743722004677	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
743722004678	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
743722004679	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
743722004680	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
743722004681	RNA binding site [nucleotide binding]; other site
743722004682	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
743722004683	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
743722004684	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
743722004685	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
743722004686	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
743722004687	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
743722004688	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
743722004689	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
743722004690	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
743722004691	23S rRNA interface [nucleotide binding]; other site
743722004692	L21e interface [polypeptide binding]; other site
743722004693	5S rRNA interface [nucleotide binding]; other site
743722004694	L27 interface [polypeptide binding]; other site
743722004695	L5 interface [polypeptide binding]; other site
743722004696	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
743722004697	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
743722004698	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
743722004699	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
743722004700	23S rRNA binding site [nucleotide binding]; other site
743722004701	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
743722004702	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
743722004703	SecY translocase; Region: SecY; pfam00344
743722004704	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
743722004705	active site
743722004706	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
743722004707	rRNA binding site [nucleotide binding]; other site
743722004708	predicted 30S ribosome binding site; other site
743722004709	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
743722004710	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
743722004711	30S ribosomal protein S13; Region: bact_S13; TIGR03631
743722004712	30S ribosomal protein S11; Validated; Region: PRK05309
743722004713	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
743722004714	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
743722004715	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743722004716	RNA binding surface [nucleotide binding]; other site
743722004717	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
743722004718	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
743722004719	alphaNTD homodimer interface [polypeptide binding]; other site
743722004720	alphaNTD - beta interaction site [polypeptide binding]; other site
743722004721	alphaNTD - beta' interaction site [polypeptide binding]; other site
743722004722	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
743722004723	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
743722004724	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743722004725	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722004726	S-adenosylmethionine binding site [chemical binding]; other site
743722004727	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
743722004728	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
743722004729	nucleotide binding site [chemical binding]; other site
743722004730	NEF interaction site [polypeptide binding]; other site
743722004731	SBD interface [polypeptide binding]; other site
743722004732	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
743722004733	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722004734	motif II; other site
743722004735	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
743722004736	active site
743722004737	FAD binding domain; Region: FAD_binding_4; pfam01565
743722004738	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
743722004739	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743722004740	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722004741	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004742	active site
743722004743	Domain of unknown function DUF87; Region: DUF87; pfam01935
743722004744	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
743722004745	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
743722004746	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722004747	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
743722004748	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
743722004749	substrate binding site; other site
743722004750	tetramer interface; other site
743722004751	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
743722004752	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
743722004753	NADP-binding site; other site
743722004754	homotetramer interface [polypeptide binding]; other site
743722004755	substrate binding site [chemical binding]; other site
743722004756	homodimer interface [polypeptide binding]; other site
743722004757	active site
743722004758	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
743722004759	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722004760	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722004761	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722004762	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
743722004763	Cupin domain; Region: Cupin_2; cl17218
743722004764	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722004765	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722004766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722004767	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722004768	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
743722004769	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722004770	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722004771	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722004772	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722004773	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
743722004774	Flavoprotein; Region: Flavoprotein; pfam02441
743722004775	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
743722004776	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
743722004777	DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105
743722004778	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
743722004779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722004780	Coenzyme A binding pocket [chemical binding]; other site
743722004781	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
743722004782	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722004783	Phosphoesterase family; Region: Phosphoesterase; pfam04185
743722004784	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
743722004785	Phosphoesterase family; Region: Phosphoesterase; pfam04185
743722004786	Domain of unknown function (DUF756); Region: DUF756; pfam05506
743722004787	Domain of unknown function (DUF756); Region: DUF756; pfam05506
743722004788	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722004789	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722004790	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722004791	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722004792	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722004793	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722004794	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722004795	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722004796	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722004797	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722004798	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722004799	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722004800	FecR protein; Region: FecR; pfam04773
743722004801	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722004802	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722004803	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722004804	DNA binding residues [nucleotide binding]
743722004805	colanic acid exporter; Provisional; Region: PRK10459
743722004806	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
743722004807	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
743722004808	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
743722004809	Mg++ binding site [ion binding]; other site
743722004810	putative catalytic motif [active]
743722004811	substrate binding site [chemical binding]; other site
743722004812	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722004813	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
743722004814	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
743722004815	active site
743722004816	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004817	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722004818	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722004819	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722004820	active site
743722004821	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722004822	active site
743722004823	putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677
743722004824	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
743722004825	trimer interface [polypeptide binding]; other site
743722004826	active site
743722004827	substrate binding site [chemical binding]; other site
743722004828	CoA binding site [chemical binding]; other site
743722004829	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722004830	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004831	active site
743722004832	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004833	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
743722004834	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
743722004835	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
743722004836	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
743722004837	SLBB domain; Region: SLBB; pfam10531
743722004838	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
743722004839	SLBB domain; Region: SLBB; pfam10531
743722004840	SLBB domain; Region: SLBB; pfam10531
743722004841	SLBB domain; Region: SLBB; pfam10531
743722004842	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
743722004843	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
743722004844	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
743722004845	Bacterial sugar transferase; Region: Bac_transf; pfam02397
743722004846	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722004847	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722004848	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722004849	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722004850	active site
743722004851	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004852	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722004853	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722004854	active site
743722004855	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722004856	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004857	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743722004858	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
743722004859	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
743722004860	trimer interface [polypeptide binding]; other site
743722004861	active site
743722004862	substrate binding site [chemical binding]; other site
743722004863	CoA binding site [chemical binding]; other site
743722004864	Glycosyltransferase WbsX; Region: Glyco_tran_WbsX; pfam14307
743722004865	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004866	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
743722004867	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
743722004868	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
743722004869	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
743722004870	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
743722004871	Chain length determinant protein; Region: Wzz; cl15801
743722004872	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
743722004873	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
743722004874	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
743722004875	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743722004876	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
743722004877	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
743722004878	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
743722004879	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
743722004880	NAD(P) binding site [chemical binding]; other site
743722004881	homodimer interface [polypeptide binding]; other site
743722004882	substrate binding site [chemical binding]; other site
743722004883	active site
743722004884	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
743722004885	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
743722004886	inhibitor-cofactor binding pocket; inhibition site
743722004887	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722004888	catalytic residue [active]
743722004889	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
743722004890	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
743722004891	putative trimer interface [polypeptide binding]; other site
743722004892	putative CoA binding site [chemical binding]; other site
743722004893	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
743722004894	NeuB family; Region: NeuB; pfam03102
743722004895	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
743722004896	NeuB binding interface [polypeptide binding]; other site
743722004897	putative substrate binding site [chemical binding]; other site
743722004898	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
743722004899	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
743722004900	active site
743722004901	homodimer interface [polypeptide binding]; other site
743722004902	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
743722004903	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
743722004904	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
743722004905	Substrate binding site; other site
743722004906	metal-binding site
743722004907	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
743722004908	ligand binding site; other site
743722004909	tetramer interface; other site
743722004910	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722004911	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722004912	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
743722004913	putative trimer interface [polypeptide binding]; other site
743722004914	putative CoA binding site [chemical binding]; other site
743722004915	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
743722004916	trimer interface [polypeptide binding]; other site
743722004917	active site
743722004918	substrate binding site [chemical binding]; other site
743722004919	CoA binding site [chemical binding]; other site
743722004920	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
743722004921	Acyltransferase family; Region: Acyl_transf_3; pfam01757
743722004922	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722004923	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722004924	active site
743722004925	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722004926	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004927	Right handed beta helix region; Region: Beta_helix; pfam13229
743722004928	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722004929	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004930	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
743722004931	active site
743722004932	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
743722004933	homodimer interface [polypeptide binding]; other site
743722004934	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722004935	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
743722004936	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722004937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722004938	NAD(P) binding site [chemical binding]; other site
743722004939	active site
743722004940	Uncharacterized conserved protein [Function unknown]; Region: COG1434
743722004941	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
743722004942	putative active site [active]
743722004943	The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854
743722004944	Mg++ binding site [ion binding]; other site
743722004945	putative catalytic motif [active]
743722004946	putative substrate binding site [chemical binding]; other site
743722004947	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
743722004948	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
743722004949	NAD(P) binding site [chemical binding]; other site
743722004950	homodimer interface [polypeptide binding]; other site
743722004951	substrate binding site [chemical binding]; other site
743722004952	active site
743722004953	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
743722004954	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
743722004955	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
743722004956	oligomeric interface; other site
743722004957	putative active site [active]
743722004958	homodimer interface [polypeptide binding]; other site
743722004959	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722004960	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722004961	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
743722004962	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
743722004963	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722004964	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722004965	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722004966	catalytic residues [active]
743722004967	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
743722004968	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722004969	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722004970	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722004971	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722004972	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722004973	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722004974	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722004975	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
743722004976	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722004977	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722004978	active site
743722004979	phosphorylation site [posttranslational modification]
743722004980	intermolecular recognition site; other site
743722004981	dimerization interface [polypeptide binding]; other site
743722004982	LytTr DNA-binding domain; Region: LytTR; pfam04397
743722004983	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
743722004984	Histidine kinase; Region: His_kinase; pfam06580
743722004985	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722004986	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722004987	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722004988	Helix-turn-helix domain; Region: HTH_17; pfam12728
743722004989	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
743722004990	GIY-YIG motif/motif A; other site
743722004991	putative active site [active]
743722004992	putative metal binding site [ion binding]; other site
743722004993	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722004994	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722004995	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722004996	DNA binding residues [nucleotide binding]
743722004997	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722004998	FecR protein; Region: FecR; pfam04773
743722004999	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722005000	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005001	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005002	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005003	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005004	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005005	SusD family; Region: SusD; pfam07980
743722005006	PIN domain; Region: PIN_3; cl17397
743722005007	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
743722005008	Protein of unknown function (DUF433); Region: DUF433; pfam04255
743722005009	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722005010	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005011	DNA binding residues [nucleotide binding]
743722005012	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722005013	FecR protein; Region: FecR; pfam04773
743722005014	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005015	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005016	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005017	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005018	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005019	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005020	Two component regulator propeller; Region: Reg_prop; pfam07494
743722005021	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722005022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005024	dimer interface [polypeptide binding]; other site
743722005025	phosphorylation site [posttranslational modification]
743722005026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005027	ATP binding site [chemical binding]; other site
743722005028	Mg2+ binding site [ion binding]; other site
743722005029	G-X-G motif; other site
743722005030	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722005031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005032	active site
743722005033	phosphorylation site [posttranslational modification]
743722005034	intermolecular recognition site; other site
743722005035	dimerization interface [polypeptide binding]; other site
743722005036	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722005037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722005038	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005039	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005040	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005041	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005042	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005043	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005044	SusD family; Region: SusD; pfam07980
743722005045	Predicted periplasmic protein [Function unknown]; Region: COG3698
743722005046	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
743722005047	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005048	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005049	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722005050	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005051	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005052	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005053	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005054	FecR protein; Region: FecR; pfam04773
743722005055	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
743722005056	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722005057	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005059	DNA binding residues [nucleotide binding]
743722005060	Predicted transcriptional regulator [Transcription]; Region: COG2378
743722005061	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
743722005062	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
743722005063	putative active site [active]
743722005064	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722005065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722005066	Walker A/P-loop; other site
743722005067	ATP binding site [chemical binding]; other site
743722005068	Q-loop/lid; other site
743722005069	ABC transporter signature motif; other site
743722005070	Walker B; other site
743722005071	D-loop; other site
743722005072	H-loop/switch region; other site
743722005073	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
743722005074	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
743722005075	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722005076	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005077	SusD family; Region: SusD; pfam07980
743722005078	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005079	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005080	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005081	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005082	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722005083	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
743722005084	BNR repeat-like domain; Region: BNR_2; pfam13088
743722005085	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722005086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005087	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005088	DNA binding residues [nucleotide binding]
743722005089	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005090	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005091	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722005092	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005093	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722005094	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005095	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005096	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; pfam10142
743722005097	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743722005098	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
743722005099	putative active site [active]
743722005100	catalytic site [active]
743722005101	putative metal binding site [ion binding]; other site
743722005102	oligomer interface [polypeptide binding]; other site
743722005103	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743722005104	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
743722005105	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722005106	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722005107	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
743722005108	putative dimerization interface [polypeptide binding]; other site
743722005109	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
743722005110	putative ligand binding site [chemical binding]; other site
743722005111	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722005112	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722005113	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722005114	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743722005115	nucleotide binding site [chemical binding]; other site
743722005116	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
743722005117	Carbon starvation protein CstA; Region: CstA; pfam02554
743722005118	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
743722005119	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
743722005120	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
743722005121	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
743722005122	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743722005123	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722005124	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743722005125	dimerization interface [polypeptide binding]; other site
743722005126	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743722005127	homodimer interface [polypeptide binding]; other site
743722005128	cystathionine beta-lyase; Provisional; Region: PRK07671
743722005129	substrate-cofactor binding pocket; other site
743722005130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722005131	catalytic residue [active]
743722005132	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
743722005133	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722005134	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722005135	active site
743722005136	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722005137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005139	DNA binding residues [nucleotide binding]
743722005140	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722005141	FecR protein; Region: FecR; pfam04773
743722005142	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005143	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005144	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005145	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005146	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005147	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005148	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005149	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
743722005150	Interdomain contacts; other site
743722005151	Cytokine receptor motif; other site
743722005152	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722005153	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722005154	active site
743722005155	metal binding site [ion binding]; metal-binding site
743722005156	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722005157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005158	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005159	DNA binding residues [nucleotide binding]
743722005160	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722005161	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722005162	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722005163	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722005164	putative deaminase; Validated; Region: PRK06846
743722005165	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
743722005166	active site
743722005167	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722005168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722005169	FecR protein; Region: FecR; pfam04773
743722005170	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005171	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005172	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005173	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005174	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005175	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722005176	active site
743722005177	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005178	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005179	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005180	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005181	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722005182	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005183	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
743722005184	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722005185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005186	active site
743722005187	phosphorylation site [posttranslational modification]
743722005188	intermolecular recognition site; other site
743722005189	dimerization interface [polypeptide binding]; other site
743722005190	LytTr DNA-binding domain; Region: LytTR; smart00850
743722005191	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
743722005192	Histidine kinase; Region: HisKA_2; pfam07568
743722005193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005194	ATP binding site [chemical binding]; other site
743722005195	Mg2+ binding site [ion binding]; other site
743722005196	G-X-G motif; other site
743722005197	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
743722005198	Bacterial sugar transferase; Region: Bac_transf; pfam02397
743722005199	Cupin domain; Region: Cupin_2; cl17218
743722005200	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
743722005201	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
743722005202	NADP-binding site; other site
743722005203	homotetramer interface [polypeptide binding]; other site
743722005204	substrate binding site [chemical binding]; other site
743722005205	homodimer interface [polypeptide binding]; other site
743722005206	active site
743722005207	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
743722005208	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722005209	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
743722005210	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
743722005211	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722005212	active site
743722005213	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
743722005214	trimer interface [polypeptide binding]; other site
743722005215	active site
743722005216	substrate binding site [chemical binding]; other site
743722005217	CoA binding site [chemical binding]; other site
743722005218	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005219	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722005220	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
743722005221	Core-2/I-Branching enzyme; Region: Branch; pfam02485
743722005222	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722005223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005224	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005225	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
743722005226	putative ADP-binding pocket [chemical binding]; other site
743722005227	colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008
743722005228	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
743722005229	putative trimer interface [polypeptide binding]; other site
743722005230	putative active site [active]
743722005231	putative substrate binding site [chemical binding]; other site
743722005232	putative CoA binding site [chemical binding]; other site
743722005233	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722005234	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
743722005235	putative metal binding site; other site
743722005236	putative glycosyl transferase; Provisional; Region: PRK10307
743722005237	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
743722005238	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
743722005239	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
743722005240	SLBB domain; Region: SLBB; pfam10531
743722005241	Chain length determinant protein; Region: Wzz; cl15801
743722005242	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
743722005243	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
743722005244	AAA domain; Region: AAA_31; pfam13614
743722005245	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743722005246	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
743722005247	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
743722005248	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
743722005249	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743722005250	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
743722005251	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743722005252	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722005253	motif II; other site
743722005254	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722005255	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005257	DNA binding residues [nucleotide binding]
743722005258	FecR protein; Region: FecR; pfam04773
743722005259	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005260	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005261	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005262	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005263	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005264	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005265	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
743722005266	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
743722005267	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
743722005268	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005269	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005270	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005271	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722005272	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005273	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
743722005274	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722005275	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722005276	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722005277	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722005278	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005279	SusD family; Region: SusD; pfam07980
743722005280	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005281	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005282	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722005283	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722005284	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722005285	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722005286	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005287	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005288	dimer interface [polypeptide binding]; other site
743722005289	phosphorylation site [posttranslational modification]
743722005290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005291	ATP binding site [chemical binding]; other site
743722005292	Mg2+ binding site [ion binding]; other site
743722005293	G-X-G motif; other site
743722005294	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005296	active site
743722005297	phosphorylation site [posttranslational modification]
743722005298	intermolecular recognition site; other site
743722005299	dimerization interface [polypeptide binding]; other site
743722005300	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722005301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722005302	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
743722005303	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
743722005304	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722005305	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722005306	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
743722005307	active site
743722005308	catalytic residues [active]
743722005309	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722005310	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722005311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722005312	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
743722005313	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
743722005314	active site
743722005315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
743722005316	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722005317	DNA-binding site [nucleotide binding]; DNA binding site
743722005318	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
743722005319	putative dimerization interface [polypeptide binding]; other site
743722005320	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722005321	putative ligand binding site [chemical binding]; other site
743722005322	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005323	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005324	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005325	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722005326	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722005327	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722005328	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
743722005329	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
743722005330	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722005331	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
743722005332	active site
743722005333	catalytic triad [active]
743722005334	oxyanion hole [active]
743722005335	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
743722005336	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
743722005337	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
743722005338	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722005339	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
743722005340	Na binding site [ion binding]; other site
743722005341	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
743722005342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722005343	ATP binding site [chemical binding]; other site
743722005344	putative Mg++ binding site [ion binding]; other site
743722005345	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722005346	nucleotide binding region [chemical binding]; other site
743722005347	ATP-binding site [chemical binding]; other site
743722005348	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
743722005349	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
743722005350	Predicted membrane protein [Function unknown]; Region: COG2311
743722005351	Protein of unknown function (DUF418); Region: DUF418; cl12135
743722005352	Protein of unknown function (DUF418); Region: DUF418; pfam04235
743722005353	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
743722005354	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722005355	active site
743722005356	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
743722005357	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
743722005358	Substrate binding site; other site
743722005359	VanZ like family; Region: VanZ; cl01971
743722005360	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
743722005361	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
743722005362	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
743722005363	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
743722005364	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722005365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005366	active site
743722005367	phosphorylation site [posttranslational modification]
743722005368	intermolecular recognition site; other site
743722005369	dimerization interface [polypeptide binding]; other site
743722005370	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722005371	DNA binding residues [nucleotide binding]
743722005372	dimerization interface [polypeptide binding]; other site
743722005373	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722005374	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722005375	gliding motility associated protien GldN; Region: GldN; TIGR03523
743722005376	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
743722005377	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
743722005378	GldM N-terminal domain; Region: GldM_N; pfam12081
743722005379	GldM C-terminal domain; Region: GldM_C; pfam12080
743722005380	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
743722005381	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
743722005382	NADP binding site [chemical binding]; other site
743722005383	active site
743722005384	putative substrate binding site [chemical binding]; other site
743722005385	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743722005386	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
743722005387	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
743722005388	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
743722005389	FMN binding site [chemical binding]; other site
743722005390	dimer interface [polypeptide binding]; other site
743722005391	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
743722005392	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
743722005393	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
743722005394	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722005395	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722005396	active site
743722005397	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
743722005398	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
743722005399	active site
743722005400	substrate binding site [chemical binding]; other site
743722005401	metal binding site [ion binding]; metal-binding site
743722005402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722005403	non-specific DNA binding site [nucleotide binding]; other site
743722005404	salt bridge; other site
743722005405	sequence-specific DNA binding site [nucleotide binding]; other site
743722005406	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
743722005407	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743722005408	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722005409	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722005410	active site
743722005411	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
743722005412	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
743722005413	inhibitor-cofactor binding pocket; inhibition site
743722005414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722005415	catalytic residue [active]
743722005416	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
743722005417	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
743722005418	SLBB domain; Region: SLBB; pfam10531
743722005419	Chain length determinant protein; Region: Wzz; cl15801
743722005420	cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841
743722005421	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
743722005422	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743722005423	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
743722005424	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005425	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743722005426	putative acyl transferase; Provisional; Region: PRK10191
743722005427	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
743722005428	trimer interface [polypeptide binding]; other site
743722005429	active site
743722005430	substrate binding site [chemical binding]; other site
743722005431	CoA binding site [chemical binding]; other site
743722005432	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005433	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
743722005434	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
743722005435	Exo-beta-1,3-glucanase [Carbohydrate transport and metabolism]; Region: COG5309
743722005436	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
743722005437	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005438	putative ADP-binding pocket [chemical binding]; other site
743722005439	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
743722005440	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
743722005441	Bacterial sugar transferase; Region: Bac_transf; pfam02397
743722005442	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722005443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005444	active site
743722005445	phosphorylation site [posttranslational modification]
743722005446	intermolecular recognition site; other site
743722005447	dimerization interface [polypeptide binding]; other site
743722005448	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722005449	DNA binding residues [nucleotide binding]
743722005450	dimerization interface [polypeptide binding]; other site
743722005451	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005453	active site
743722005454	phosphorylation site [posttranslational modification]
743722005455	intermolecular recognition site; other site
743722005456	dimerization interface [polypeptide binding]; other site
743722005457	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005459	dimer interface [polypeptide binding]; other site
743722005460	phosphorylation site [posttranslational modification]
743722005461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005462	ATP binding site [chemical binding]; other site
743722005463	G-X-G motif; other site
743722005464	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
743722005465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005466	active site
743722005467	phosphorylation site [posttranslational modification]
743722005468	intermolecular recognition site; other site
743722005469	dimerization interface [polypeptide binding]; other site
743722005470	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
743722005471	ATP binding site [chemical binding]; other site
743722005472	substrate interface [chemical binding]; other site
743722005473	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
743722005474	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
743722005475	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005476	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005477	dimer interface [polypeptide binding]; other site
743722005478	phosphorylation site [posttranslational modification]
743722005479	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005480	ATP binding site [chemical binding]; other site
743722005481	Mg2+ binding site [ion binding]; other site
743722005482	G-X-G motif; other site
743722005483	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005484	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005485	active site
743722005486	phosphorylation site [posttranslational modification]
743722005487	intermolecular recognition site; other site
743722005488	dimerization interface [polypeptide binding]; other site
743722005489	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722005490	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722005491	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722005492	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722005493	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722005494	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722005495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005496	active site
743722005497	phosphorylation site [posttranslational modification]
743722005498	intermolecular recognition site; other site
743722005499	dimerization interface [polypeptide binding]; other site
743722005500	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722005501	DNA binding site [nucleotide binding]
743722005502	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005504	dimer interface [polypeptide binding]; other site
743722005505	phosphorylation site [posttranslational modification]
743722005506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005507	ATP binding site [chemical binding]; other site
743722005508	Mg2+ binding site [ion binding]; other site
743722005509	G-X-G motif; other site
743722005510	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722005511	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005512	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722005513	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722005514	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722005515	SusD family; Region: SusD; pfam07980
743722005516	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722005517	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
743722005518	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722005519	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722005520	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722005521	Peptidase of plants and bacteria; Region: BSP; pfam04450
743722005522	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722005523	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722005524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005526	ATP binding site [chemical binding]; other site
743722005527	Mg2+ binding site [ion binding]; other site
743722005528	G-X-G motif; other site
743722005529	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005531	active site
743722005532	phosphorylation site [posttranslational modification]
743722005533	intermolecular recognition site; other site
743722005534	dimerization interface [polypeptide binding]; other site
743722005535	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
743722005536	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
743722005537	glutaminase active site [active]
743722005538	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
743722005539	dimer interface [polypeptide binding]; other site
743722005540	active site
743722005541	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
743722005542	dimer interface [polypeptide binding]; other site
743722005543	active site
743722005544	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
743722005545	Bacterial sugar transferase; Region: Bac_transf; pfam02397
743722005546	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722005547	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
743722005548	active site
743722005549	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722005550	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
743722005551	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743722005552	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005553	O-Antigen ligase; Region: Wzy_C; pfam04932
743722005554	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005555	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
743722005556	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005557	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722005558	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722005559	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
743722005560	active site
743722005561	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
743722005562	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
743722005563	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
743722005564	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005565	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005566	dimer interface [polypeptide binding]; other site
743722005567	phosphorylation site [posttranslational modification]
743722005568	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005569	ATP binding site [chemical binding]; other site
743722005570	Mg2+ binding site [ion binding]; other site
743722005571	G-X-G motif; other site
743722005572	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
743722005573	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743722005574	dimer interface [polypeptide binding]; other site
743722005575	active site
743722005576	CoA binding pocket [chemical binding]; other site
743722005577	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
743722005578	Uncharacterized subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u3; cd12832
743722005579	oligomer interface [polypeptide binding]; other site
743722005580	metal binding site [ion binding]; metal-binding site
743722005581	putative Cl binding site [ion binding]; other site
743722005582	basic sphincter; other site
743722005583	hydrophobic gate; other site
743722005584	periplasmic entrance; other site
743722005585	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722005586	putative catalytic site [active]
743722005587	putative metal binding site [ion binding]; other site
743722005588	putative phosphate binding site [ion binding]; other site
743722005589	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
743722005590	putative substrate binding site [chemical binding]; other site
743722005591	active site
743722005592	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
743722005593	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
743722005594	NADP binding site [chemical binding]; other site
743722005595	active site
743722005596	putative substrate binding site [chemical binding]; other site
743722005597	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
743722005598	dimer interface [polypeptide binding]; other site
743722005599	ADP-ribose binding site [chemical binding]; other site
743722005600	active site
743722005601	nudix motif; other site
743722005602	metal binding site [ion binding]; metal-binding site
743722005603	glycine dehydrogenase; Provisional; Region: PRK05367
743722005604	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
743722005605	tetramer interface [polypeptide binding]; other site
743722005606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722005607	catalytic residue [active]
743722005608	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
743722005609	tetramer interface [polypeptide binding]; other site
743722005610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722005611	catalytic residue [active]
743722005612	MG2 domain; Region: A2M_N; pfam01835
743722005613	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
743722005614	Malic enzyme, N-terminal domain; Region: malic; pfam00390
743722005615	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
743722005616	putative NAD(P) binding site [chemical binding]; other site
743722005617	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
743722005618	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
743722005619	RuvA N terminal domain; Region: RuvA_N; pfam01330
743722005620	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
743722005621	Domain of unknown function DUF11; Region: DUF11; cl17728
743722005622	conserved repeat domain; Region: B_ant_repeat; TIGR01451
743722005623	conserved repeat domain; Region: B_ant_repeat; TIGR01451
743722005624	Domain of unknown function DUF11; Region: DUF11; cl17728
743722005625	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005626	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005627	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005628	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005629	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005630	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005631	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005632	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005633	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
743722005634	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
743722005635	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
743722005636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722005637	binding surface
743722005638	TPR motif; other site
743722005639	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
743722005640	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
743722005641	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722005642	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722005643	ligand binding site [chemical binding]; other site
743722005644	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722005645	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005646	active site
743722005647	phosphorylation site [posttranslational modification]
743722005648	intermolecular recognition site; other site
743722005649	dimerization interface [polypeptide binding]; other site
743722005650	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722005651	DNA binding residues [nucleotide binding]
743722005652	dimerization interface [polypeptide binding]; other site
743722005653	YtxH-like protein; Region: YtxH; cl02079
743722005654	CheB methylesterase; Region: CheB_methylest; pfam01339
743722005655	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005656	Histidine kinase; Region: His_kinase; pfam06580
743722005657	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005658	ATP binding site [chemical binding]; other site
743722005659	Mg2+ binding site [ion binding]; other site
743722005660	G-X-G motif; other site
743722005661	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
743722005662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005663	active site
743722005664	phosphorylation site [posttranslational modification]
743722005665	intermolecular recognition site; other site
743722005666	dimerization interface [polypeptide binding]; other site
743722005667	LytTr DNA-binding domain; Region: LytTR; smart00850
743722005668	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
743722005669	GAF domain; Region: GAF; pfam01590
743722005670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722005671	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
743722005672	putative active site [active]
743722005673	heme pocket [chemical binding]; other site
743722005674	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005675	dimer interface [polypeptide binding]; other site
743722005676	phosphorylation site [posttranslational modification]
743722005677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005678	ATP binding site [chemical binding]; other site
743722005679	Mg2+ binding site [ion binding]; other site
743722005680	G-X-G motif; other site
743722005681	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
743722005682	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
743722005683	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
743722005684	IHF dimer interface [polypeptide binding]; other site
743722005685	IHF - DNA interface [nucleotide binding]; other site
743722005686	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722005687	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722005688	ligand binding site [chemical binding]; other site
743722005689	flexible hinge region; other site
743722005690	Domain of unknown function (DUF4406); Region: DUF4406; pfam14359
743722005691	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
743722005692	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
743722005693	dimer interface [polypeptide binding]; other site
743722005694	ADP-ribose binding site [chemical binding]; other site
743722005695	active site
743722005696	nudix motif; other site
743722005697	metal binding site [ion binding]; metal-binding site
743722005698	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722005699	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
743722005700	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005702	active site
743722005703	phosphorylation site [posttranslational modification]
743722005704	intermolecular recognition site; other site
743722005705	dimerization interface [polypeptide binding]; other site
743722005706	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
743722005707	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722005708	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
743722005709	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722005710	N-terminal plug; other site
743722005711	ligand-binding site [chemical binding]; other site
743722005712	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
743722005713	Uncharacterized conserved protein (DUF2149); Region: DUF2149; pfam09919
743722005714	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
743722005715	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
743722005716	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
743722005717	Domain of unknown function (DUF389); Region: DUF389; pfam04087
743722005718	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722005719	active site
743722005720	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005721	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
743722005722	putative ADP-binding pocket [chemical binding]; other site
743722005723	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722005724	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
743722005725	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
743722005726	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
743722005727	dimer interface [polypeptide binding]; other site
743722005728	active site
743722005729	CoA binding pocket [chemical binding]; other site
743722005730	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722005731	DNA-binding site [nucleotide binding]; DNA binding site
743722005732	RNA-binding motif; other site
743722005733	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722005734	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722005735	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
743722005736	active site clefts [active]
743722005737	zinc binding site [ion binding]; other site
743722005738	dimer interface [polypeptide binding]; other site
743722005739	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722005740	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722005741	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722005742	DNA binding residues [nucleotide binding]
743722005743	AAA domain; Region: AAA_18; pfam13238
743722005744	AAA domain; Region: AAA_17; cl17253
743722005745	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743722005746	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
743722005747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722005748	Coenzyme A binding pocket [chemical binding]; other site
743722005749	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722005750	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743722005751	Right handed beta helix region; Region: Beta_helix; pfam13229
743722005752	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743722005753	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743722005754	CsbD-like; Region: CsbD; pfam05532
743722005755	Domain of unknown function (DUF2383); Region: DUF2383; cl17556
743722005756	short chain dehydrogenase; Provisional; Region: PRK06701
743722005757	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
743722005758	NAD binding site [chemical binding]; other site
743722005759	metal binding site [ion binding]; metal-binding site
743722005760	active site
743722005761	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722005762	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722005763	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722005764	putative catalytic site [active]
743722005765	putative metal binding site [ion binding]; other site
743722005766	putative phosphate binding site [ion binding]; other site
743722005767	Family description; Region: VCBS; pfam13517
743722005768	Family description; Region: VCBS; pfam13517
743722005769	Family description; Region: VCBS; pfam13517
743722005770	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722005771	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005772	active site
743722005773	phosphorylation site [posttranslational modification]
743722005774	intermolecular recognition site; other site
743722005775	dimerization interface [polypeptide binding]; other site
743722005776	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
743722005777	DNA binding residues [nucleotide binding]
743722005778	dimerization interface [polypeptide binding]; other site
743722005779	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
743722005780	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
743722005781	DsrE/DsrF-like family; Region: DrsE; cl00672
743722005782	Cytochrome c [Energy production and conversion]; Region: COG3258
743722005783	Cytochrome c; Region: Cytochrom_C; pfam00034
743722005784	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
743722005785	Isochorismatase family; Region: Isochorismatase; pfam00857
743722005786	catalytic triad [active]
743722005787	metal binding site [ion binding]; metal-binding site
743722005788	conserved cis-peptide bond; other site
743722005789	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
743722005790	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
743722005791	MOSC domain; Region: MOSC; pfam03473
743722005792	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
743722005793	CheB methylesterase; Region: CheB_methylest; pfam01339
743722005794	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
743722005795	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
743722005796	PAS domain; Region: PAS_10; pfam13596
743722005797	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722005798	PAS fold; Region: PAS_3; pfam08447
743722005799	putative active site [active]
743722005800	heme pocket [chemical binding]; other site
743722005801	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005802	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005803	dimer interface [polypeptide binding]; other site
743722005804	phosphorylation site [posttranslational modification]
743722005805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005806	ATP binding site [chemical binding]; other site
743722005807	Mg2+ binding site [ion binding]; other site
743722005808	G-X-G motif; other site
743722005809	PAS fold; Region: PAS_2; pfam08446
743722005810	GAF domain; Region: GAF; pfam01590
743722005811	Phytochrome region; Region: PHY; pfam00360
743722005812	CsbD-like; Region: CsbD; pfam05532
743722005813	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
743722005814	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
743722005815	dimer interface [polypeptide binding]; other site
743722005816	active site
743722005817	catalytic residue [active]
743722005818	metal binding site [ion binding]; metal-binding site
743722005819	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
743722005820	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
743722005821	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
743722005822	Sodium Bile acid symporter family; Region: SBF; cl17470
743722005823	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
743722005824	substrate binding site [chemical binding]; other site
743722005825	active site
743722005826	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
743722005827	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722005828	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005830	active site
743722005831	phosphorylation site [posttranslational modification]
743722005832	intermolecular recognition site; other site
743722005833	dimerization interface [polypeptide binding]; other site
743722005834	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
743722005835	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
743722005836	DNA binding residues [nucleotide binding]
743722005837	dimerization interface [polypeptide binding]; other site
743722005838	Predicted membrane protein [Function unknown]; Region: COG2323
743722005839	Predicted membrane protein [Function unknown]; Region: COG2323
743722005840	Predicted membrane protein [Function unknown]; Region: COG2323
743722005841	Response regulator receiver domain; Region: Response_reg; pfam00072
743722005842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722005843	active site
743722005844	phosphorylation site [posttranslational modification]
743722005845	intermolecular recognition site; other site
743722005846	dimerization interface [polypeptide binding]; other site
743722005847	short chain dehydrogenase; Provisional; Region: PRK12828
743722005848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722005849	NAD(P) binding site [chemical binding]; other site
743722005850	active site
743722005851	glycogen branching enzyme; Provisional; Region: PRK12313
743722005852	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
743722005853	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
743722005854	active site
743722005855	catalytic site [active]
743722005856	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
743722005857	trehalose synthase; Region: treS_nterm; TIGR02456
743722005858	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
743722005859	active site
743722005860	catalytic site [active]
743722005861	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
743722005862	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
743722005863	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
743722005864	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
743722005865	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
743722005866	active site
743722005867	homodimer interface [polypeptide binding]; other site
743722005868	catalytic site [active]
743722005869	acceptor binding site [chemical binding]; other site
743722005870	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
743722005871	putative dimer interface [polypeptide binding]; other site
743722005872	catalytic triad [active]
743722005873	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
743722005874	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722005875	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
743722005876	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
743722005877	dimanganese center [ion binding]; other site
743722005878	PAS domain; Region: PAS_9; pfam13426
743722005879	PAS domain S-box; Region: sensory_box; TIGR00229
743722005880	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722005881	putative active site [active]
743722005882	heme pocket [chemical binding]; other site
743722005883	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
743722005884	GAF domain; Region: GAF; pfam01590
743722005885	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722005886	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722005887	dimer interface [polypeptide binding]; other site
743722005888	phosphorylation site [posttranslational modification]
743722005889	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722005890	ATP binding site [chemical binding]; other site
743722005891	Mg2+ binding site [ion binding]; other site
743722005892	G-X-G motif; other site
743722005893	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
743722005894	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
743722005895	TPP-binding site [chemical binding]; other site
743722005896	dimer interface [polypeptide binding]; other site
743722005897	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743722005898	PYR/PP interface [polypeptide binding]; other site
743722005899	dimer interface [polypeptide binding]; other site
743722005900	TPP binding site [chemical binding]; other site
743722005901	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722005902	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
743722005903	putative active site [active]
743722005904	transaldolase; Provisional; Region: PRK03903
743722005905	catalytic residue [active]
743722005906	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
743722005907	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722005908	motif II; other site
743722005909	cell surface protein SprA; Region: surface_SprA; TIGR04189
743722005910	Motility related/secretion protein; Region: SprA_N; pfam14349
743722005911	Motility related/secretion protein; Region: SprA_N; pfam14349
743722005912	Motility related/secretion protein; Region: SprA_N; pfam14349
743722005913	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
743722005914	lipoyl attachment site [posttranslational modification]; other site
743722005915	VanZ like family; Region: VanZ; cl01971
743722005916	FeoA domain; Region: FeoA; pfam04023
743722005917	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
743722005918	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
743722005919	G1 box; other site
743722005920	GTP/Mg2+ binding site [chemical binding]; other site
743722005921	Switch I region; other site
743722005922	G2 box; other site
743722005923	G3 box; other site
743722005924	Switch II region; other site
743722005925	G4 box; other site
743722005926	G5 box; other site
743722005927	Nucleoside recognition; Region: Gate; pfam07670
743722005928	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
743722005929	Nucleoside recognition; Region: Gate; pfam07670
743722005930	SprT-like family; Region: SprT-like; pfam10263
743722005931	Protein of unknown function, DUF480; Region: DUF480; pfam04337
743722005932	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
743722005933	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
743722005934	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
743722005935	pyruvate dehydrogenase; Provisional; Region: PRK06546
743722005936	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
743722005937	PYR/PP interface [polypeptide binding]; other site
743722005938	tetramer interface [polypeptide binding]; other site
743722005939	dimer interface [polypeptide binding]; other site
743722005940	TPP binding site [chemical binding]; other site
743722005941	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
743722005942	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
743722005943	TPP-binding site [chemical binding]; other site
743722005944	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
743722005945	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
743722005946	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
743722005947	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
743722005948	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
743722005949	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
743722005950	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
743722005951	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722005952	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
743722005953	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722005954	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
743722005955	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722005956	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
743722005957	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
743722005958	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
743722005959	active site
743722005960	LysE type translocator; Region: LysE; pfam01810
743722005961	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
743722005962	catalytic motif [active]
743722005963	Zn binding site [ion binding]; other site
743722005964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722005965	S-adenosylmethionine binding site [chemical binding]; other site
743722005966	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
743722005967	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
743722005968	Ferritin-like domain; Region: Ferritin; pfam00210
743722005969	ferroxidase diiron center [ion binding]; other site
743722005970	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722005971	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722005972	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722005973	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722005974	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
743722005975	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722005976	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
743722005977	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
743722005978	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
743722005979	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
743722005980	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
743722005981	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722005982	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722005983	binding surface
743722005984	TPR motif; other site
743722005985	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
743722005986	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
743722005987	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
743722005988	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
743722005989	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
743722005990	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
743722005991	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
743722005992	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722005993	active site
743722005994	Protein of unknown function (DUF983); Region: DUF983; cl02211
743722005995	Predicted metalloprotease [General function prediction only]; Region: COG2321
743722005996	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
743722005997	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
743722005998	aconitate hydratase, mitochondrial; Region: aconitase_mito; TIGR01340
743722005999	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Mitochondrial; cd01584
743722006000	substrate binding site [chemical binding]; other site
743722006001	ligand binding site [chemical binding]; other site
743722006002	Mitochondrial aconitase A swivel domain. Aconitase (also known as aconitate hydratase and citrate hydro-lyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes...; Region: AcnA_Mitochon_Swivel; cd01578
743722006003	substrate binding site [chemical binding]; other site
743722006004	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
743722006005	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
743722006006	GMP synthase; Reviewed; Region: guaA; PRK00074
743722006007	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
743722006008	AMP/PPi binding site [chemical binding]; other site
743722006009	candidate oxyanion hole; other site
743722006010	catalytic triad [active]
743722006011	potential glutamine specificity residues [chemical binding]; other site
743722006012	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
743722006013	ATP Binding subdomain [chemical binding]; other site
743722006014	Ligand Binding sites [chemical binding]; other site
743722006015	Dimerization subdomain; other site
743722006016	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
743722006017	ligand binding site [chemical binding]; other site
743722006018	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
743722006019	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
743722006020	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
743722006021	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
743722006022	amino acid transporter; Region: 2A0306; TIGR00909
743722006023	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
743722006024	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
743722006025	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
743722006026	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
743722006027	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
743722006028	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
743722006029	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
743722006030	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722006031	active site
743722006032	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743722006033	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743722006034	active site
743722006035	malate:quinone oxidoreductase; Validated; Region: PRK05257
743722006036	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
743722006037	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722006038	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743722006039	nucleotide binding site [chemical binding]; other site
743722006040	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
743722006041	dimer interface [polypeptide binding]; other site
743722006042	phosphorylation site [posttranslational modification]
743722006043	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722006044	ATP binding site [chemical binding]; other site
743722006045	Mg2+ binding site [ion binding]; other site
743722006046	G-X-G motif; other site
743722006047	Response regulator receiver domain; Region: Response_reg; pfam00072
743722006048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722006049	active site
743722006050	phosphorylation site [posttranslational modification]
743722006051	intermolecular recognition site; other site
743722006052	dimerization interface [polypeptide binding]; other site
743722006053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722006054	Response regulator receiver domain; Region: Response_reg; pfam00072
743722006055	active site
743722006056	phosphorylation site [posttranslational modification]
743722006057	intermolecular recognition site; other site
743722006058	dimerization interface [polypeptide binding]; other site
743722006059	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
743722006060	cyclase homology domain; Region: CHD; cd07302
743722006061	nucleotidyl binding site; other site
743722006062	metal binding site [ion binding]; metal-binding site
743722006063	dimer interface [polypeptide binding]; other site
743722006064	Uncharacterized conserved protein [Function unknown]; Region: COG1284
743722006065	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
743722006066	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
743722006067	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722006068	Zn2+ binding site [ion binding]; other site
743722006069	Mg2+ binding site [ion binding]; other site
743722006070	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722006071	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722006072	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722006073	DNA binding residues [nucleotide binding]
743722006074	FecR protein; Region: FecR; pfam04773
743722006075	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722006076	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006077	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006078	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722006079	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006080	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006081	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
743722006082	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722006083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722006084	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722006085	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
743722006086	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
743722006087	proline dehydrogenase; Region: PLN02681
743722006088	S4 domain; Region: S4_2; pfam13275
743722006089	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
743722006090	active site
743722006091	dimer interface [polypeptide binding]; other site
743722006092	metal binding site [ion binding]; metal-binding site
743722006093	Trehalose utilisation; Region: ThuA; pfam06283
743722006094	threonine dehydratase; Validated; Region: PRK08639
743722006095	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
743722006096	tetramer interface [polypeptide binding]; other site
743722006097	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722006098	catalytic residue [active]
743722006099	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
743722006100	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
743722006101	tartrate dehydrogenase; Region: TTC; TIGR02089
743722006102	2-isopropylmalate synthase; Validated; Region: PRK00915
743722006103	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
743722006104	active site
743722006105	catalytic residues [active]
743722006106	metal binding site [ion binding]; metal-binding site
743722006107	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
743722006108	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
743722006109	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
743722006110	substrate binding site [chemical binding]; other site
743722006111	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
743722006112	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
743722006113	substrate binding site [chemical binding]; other site
743722006114	ligand binding site [chemical binding]; other site
743722006115	2-isopropylmalate synthase; Validated; Region: PRK00915
743722006116	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
743722006117	active site
743722006118	catalytic residues [active]
743722006119	metal binding site [ion binding]; metal-binding site
743722006120	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
743722006121	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722006122	ABC transporter signature motif; other site
743722006123	Walker B; other site
743722006124	D-loop; other site
743722006125	H-loop/switch region; other site
743722006126	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
743722006127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722006128	Walker A/P-loop; other site
743722006129	ATP binding site [chemical binding]; other site
743722006130	Q-loop/lid; other site
743722006131	ABC transporter signature motif; other site
743722006132	Walker B; other site
743722006133	D-loop; other site
743722006134	H-loop/switch region; other site
743722006135	ketol-acid reductoisomerase; Validated; Region: PRK05225
743722006136	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
743722006137	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
743722006138	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
743722006139	DinB superfamily; Region: DinB_2; pfam12867
743722006140	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
743722006141	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
743722006142	putative valine binding site [chemical binding]; other site
743722006143	dimer interface [polypeptide binding]; other site
743722006144	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
743722006145	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
743722006146	four helix bundle protein; Region: TIGR02436
743722006147	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
743722006148	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
743722006149	PYR/PP interface [polypeptide binding]; other site
743722006150	dimer interface [polypeptide binding]; other site
743722006151	TPP binding site [chemical binding]; other site
743722006152	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
743722006153	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
743722006154	TPP-binding site [chemical binding]; other site
743722006155	dimer interface [polypeptide binding]; other site
743722006156	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
743722006157	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
743722006158	gamma subunit interface [polypeptide binding]; other site
743722006159	epsilon subunit interface [polypeptide binding]; other site
743722006160	LBP interface [polypeptide binding]; other site
743722006161	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
743722006162	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
743722006163	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
743722006164	alpha subunit interaction interface [polypeptide binding]; other site
743722006165	Walker A motif; other site
743722006166	ATP binding site [chemical binding]; other site
743722006167	Walker B motif; other site
743722006168	inhibitor binding site; inhibition site
743722006169	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
743722006170	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
743722006171	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
743722006172	NADP binding site [chemical binding]; other site
743722006173	active site
743722006174	putative substrate binding site [chemical binding]; other site
743722006175	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
743722006176	Transglycosylase; Region: Transgly; cl17702
743722006177	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
743722006178	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
743722006179	active site
743722006180	hypothetical protein; Provisional; Region: PRK13665
743722006181	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
743722006182	Na binding site [ion binding]; other site
743722006183	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743722006184	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743722006185	inhibitor site; inhibition site
743722006186	active site
743722006187	dimer interface [polypeptide binding]; other site
743722006188	catalytic residue [active]
743722006189	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722006190	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
743722006191	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006192	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006193	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722006194	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722006195	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
743722006196	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
743722006197	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
743722006198	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006199	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006200	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006201	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722006202	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006203	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006204	SusD family; Region: SusD; pfam07980
743722006205	Pectate lyase; Region: Pec_lyase_C; cl01593
743722006206	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
743722006207	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
743722006208	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
743722006209	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722006210	active site
743722006211	BNR repeat-like domain; Region: BNR_2; pfam13088
743722006212	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006213	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722006214	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722006215	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
743722006216	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
743722006217	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722006218	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
743722006219	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
743722006220	BNR repeat-like domain; Region: BNR_2; pfam13088
743722006221	Asp-box motif; other site
743722006222	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
743722006223	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743722006224	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
743722006225	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722006226	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006227	DNA-binding protein, histone-like, putative; Region: HU_rel; TIGR01201
743722006228	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
743722006229	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722006230	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722006231	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722006232	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006233	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
743722006234	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722006235	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722006236	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
743722006237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722006238	DNA-binding site [nucleotide binding]; DNA binding site
743722006239	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
743722006240	putative dimerization interface [polypeptide binding]; other site
743722006241	putative ligand binding site [chemical binding]; other site
743722006242	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722006243	Right handed beta helix region; Region: Beta_helix; pfam13229
743722006244	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006245	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006246	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722006248	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006249	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006250	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722006251	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722006252	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
743722006253	putative transporter; Provisional; Region: PRK10484
743722006254	Na binding site [ion binding]; other site
743722006255	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722006256	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722006257	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722006258	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722006259	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
743722006260	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006261	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722006262	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722006263	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
743722006264	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
743722006265	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
743722006266	CoA-transferase family III; Region: CoA_transf_3; pfam02515
743722006267	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
743722006268	CoA-transferase family III; Region: CoA_transf_3; pfam02515
743722006269	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
743722006270	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
743722006271	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722006272	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722006273	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
743722006274	active site 2 [active]
743722006275	active site 1 [active]
743722006276	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722006277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722006278	putative substrate translocation pore; other site
743722006279	sugar binding site [chemical binding]; other site
743722006280	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722006281	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722006282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722006283	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722006284	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722006285	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
743722006286	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
743722006287	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
743722006288	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
743722006289	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
743722006290	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
743722006291	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722006292	Walker A motif; other site
743722006293	ATP binding site [chemical binding]; other site
743722006294	Walker B motif; other site
743722006295	arginine finger; other site
743722006296	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
743722006297	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
743722006298	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
743722006299	Protein of unknown function (DUF904); Region: DUF904; pfam06005
743722006300	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
743722006301	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006302	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006303	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006304	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722006305	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722006306	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006307	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006308	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
743722006309	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
743722006310	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722006311	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722006312	ligand binding site [chemical binding]; other site
743722006313	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743722006314	Cysteine-rich domain; Region: CCG; pfam02754
743722006315	Cysteine-rich domain; Region: CCG; pfam02754
743722006316	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
743722006317	4Fe-4S binding domain; Region: Fer4; cl02805
743722006318	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
743722006319	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722006320	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743722006321	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722006322	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
743722006323	nudix motif; other site
743722006324	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
743722006325	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
743722006326	classical (c) SDRs; Region: SDR_c; cd05233
743722006327	NAD(P) binding site [chemical binding]; other site
743722006328	active site
743722006329	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722006330	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722006331	manganese transport protein MntH; Reviewed; Region: PRK00701
743722006332	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
743722006333	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722006334	Ligand Binding Site [chemical binding]; other site
743722006335	NlpE N-terminal domain; Region: NlpE; pfam04170
743722006336	Domain of unknown function (DUF3472); Region: DUF3472; pfam11958
743722006337	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006338	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006339	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006340	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006341	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006342	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006343	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722006344	thymidine kinase; Provisional; Region: PRK04296
743722006345	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
743722006346	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
743722006347	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
743722006348	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
743722006349	rod shape-determining protein MreC; Provisional; Region: PRK13922
743722006350	rod shape-determining protein MreC; Region: MreC; pfam04085
743722006351	rod shape-determining protein MreB; Provisional; Region: PRK13927
743722006352	MreB and similar proteins; Region: MreB_like; cd10225
743722006353	nucleotide binding site [chemical binding]; other site
743722006354	Mg binding site [ion binding]; other site
743722006355	putative protofilament interaction site [polypeptide binding]; other site
743722006356	RodZ interaction site [polypeptide binding]; other site
743722006357	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
743722006358	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
743722006359	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
743722006360	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
743722006361	purine monophosphate binding site [chemical binding]; other site
743722006362	dimer interface [polypeptide binding]; other site
743722006363	putative catalytic residues [active]
743722006364	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
743722006365	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
743722006366	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
743722006367	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
743722006368	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
743722006369	active site
743722006370	substrate binding site [chemical binding]; other site
743722006371	cosubstrate binding site; other site
743722006372	catalytic site [active]
743722006373	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743722006374	Beta-lactamase; Region: Beta-lactamase; cl17358
743722006375	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
743722006376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722006377	active site
743722006378	phosphorylation site [posttranslational modification]
743722006379	intermolecular recognition site; other site
743722006380	dimerization interface [polypeptide binding]; other site
743722006381	LytTr DNA-binding domain; Region: LytTR; smart00850
743722006382	Histidine kinase; Region: His_kinase; pfam06580
743722006383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722006384	ATP binding site [chemical binding]; other site
743722006385	Mg2+ binding site [ion binding]; other site
743722006386	G-X-G motif; other site
743722006387	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
743722006388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
743722006389	Putative glucoamylase; Region: Glycoamylase; pfam10091
743722006390	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
743722006391	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
743722006392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722006393	putative substrate translocation pore; other site
743722006394	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
743722006395	Helix-turn-helix domain; Region: HTH_19; pfam12844
743722006396	non-specific DNA binding site [nucleotide binding]; other site
743722006397	salt bridge; other site
743722006398	sequence-specific DNA binding site [nucleotide binding]; other site
743722006399	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
743722006400	Catalytic site [active]
743722006401	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743722006402	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
743722006403	active site
743722006404	DNA binding site [nucleotide binding]
743722006405	Int/Topo IB signature motif; other site
743722006406	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
743722006407	30S subunit binding site; other site
743722006408	elongation factor Tu; Reviewed; Region: PRK12735
743722006409	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
743722006410	G1 box; other site
743722006411	GEF interaction site [polypeptide binding]; other site
743722006412	GTP/Mg2+ binding site [chemical binding]; other site
743722006413	Switch I region; other site
743722006414	G2 box; other site
743722006415	G3 box; other site
743722006416	Switch II region; other site
743722006417	G4 box; other site
743722006418	G5 box; other site
743722006419	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
743722006420	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
743722006421	Antibiotic Binding Site [chemical binding]; other site
743722006422	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
743722006423	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
743722006424	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
743722006425	putative homodimer interface [polypeptide binding]; other site
743722006426	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
743722006427	heterodimer interface [polypeptide binding]; other site
743722006428	homodimer interface [polypeptide binding]; other site
743722006429	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
743722006430	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
743722006431	23S rRNA interface [nucleotide binding]; other site
743722006432	L7/L12 interface [polypeptide binding]; other site
743722006433	putative thiostrepton binding site; other site
743722006434	L25 interface [polypeptide binding]; other site
743722006435	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
743722006436	mRNA/rRNA interface [nucleotide binding]; other site
743722006437	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
743722006438	23S rRNA interface [nucleotide binding]; other site
743722006439	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
743722006440	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
743722006441	core dimer interface [polypeptide binding]; other site
743722006442	peripheral dimer interface [polypeptide binding]; other site
743722006443	L10 interface [polypeptide binding]; other site
743722006444	L11 interface [polypeptide binding]; other site
743722006445	putative EF-Tu interaction site [polypeptide binding]; other site
743722006446	putative EF-G interaction site [polypeptide binding]; other site
743722006447	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
743722006448	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
743722006449	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
743722006450	RPB11 interaction site [polypeptide binding]; other site
743722006451	RPB12 interaction site [polypeptide binding]; other site
743722006452	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
743722006453	RPB3 interaction site [polypeptide binding]; other site
743722006454	RPB1 interaction site [polypeptide binding]; other site
743722006455	RPB11 interaction site [polypeptide binding]; other site
743722006456	RPB10 interaction site [polypeptide binding]; other site
743722006457	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
743722006458	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
743722006459	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
743722006460	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
743722006461	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
743722006462	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
743722006463	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
743722006464	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
743722006465	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
743722006466	DNA binding site [nucleotide binding]
743722006467	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
743722006468	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
743722006469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722006470	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
743722006471	NAD(P) binding site [chemical binding]; other site
743722006472	active site
743722006473	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
743722006474	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
743722006475	dimer interface [polypeptide binding]; other site
743722006476	putative anticodon binding site; other site
743722006477	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
743722006478	motif 1; other site
743722006479	active site
743722006480	motif 2; other site
743722006481	motif 3; other site
743722006482	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
743722006483	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722006484	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722006485	DNA binding residues [nucleotide binding]
743722006486	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
743722006487	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722006488	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722006489	ligand binding site [chemical binding]; other site
743722006490	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
743722006491	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
743722006492	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
743722006493	dimerization interface 3.5A [polypeptide binding]; other site
743722006494	active site
743722006495	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722006496	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722006497	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
743722006498	Walker A/P-loop; other site
743722006499	ATP binding site [chemical binding]; other site
743722006500	Q-loop/lid; other site
743722006501	ABC transporter signature motif; other site
743722006502	Walker B; other site
743722006503	D-loop; other site
743722006504	H-loop/switch region; other site
743722006505	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
743722006506	CoA binding domain; Region: CoA_binding; smart00881
743722006507	CoA-ligase; Region: Ligase_CoA; pfam00549
743722006508	methionine sulfoxide reductase B; Provisional; Region: PRK05508
743722006509	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
743722006510	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722006511	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722006512	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
743722006513	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
743722006514	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
743722006515	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
743722006516	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
743722006517	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
743722006518	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
743722006519	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
743722006520	active site
743722006521	NTP binding site [chemical binding]; other site
743722006522	metal binding triad [ion binding]; metal-binding site
743722006523	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
743722006524	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722006525	Zn2+ binding site [ion binding]; other site
743722006526	Mg2+ binding site [ion binding]; other site
743722006527	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
743722006528	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
743722006529	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722006530	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
743722006531	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
743722006532	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
743722006533	trimer interface [polypeptide binding]; other site
743722006534	active site
743722006535	substrate binding site [chemical binding]; other site
743722006536	CoA binding site [chemical binding]; other site
743722006537	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
743722006538	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722006539	putative active site [active]
743722006540	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
743722006541	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
743722006542	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
743722006543	active site
743722006544	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743722006545	RNA binding surface [nucleotide binding]; other site
743722006546	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
743722006547	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
743722006548	Substrate binding site; other site
743722006549	metal-binding site
743722006550	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
743722006551	Substrate binding site; other site
743722006552	metal-binding site
743722006553	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722006554	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722006555	active site
743722006556	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743722006557	intersubunit interface [polypeptide binding]; other site
743722006558	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
743722006559	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
743722006560	Probable Catalytic site; other site
743722006561	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722006562	metal-binding site
743722006563	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
743722006564	Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712
743722006565	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722006566	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
743722006567	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722006568	Family description; Region: VCBS; pfam13517
743722006569	Family description; Region: VCBS; pfam13517
743722006570	Family description; Region: VCBS; pfam13517
743722006571	Family description; Region: VCBS; pfam13517
743722006572	Family description; Region: VCBS; pfam13517
743722006573	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722006574	ligand binding site [chemical binding]; other site
743722006575	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722006576	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722006577	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006578	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006579	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006580	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722006581	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006582	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006583	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006584	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006585	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
743722006586	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006587	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006588	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006589	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006590	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006591	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006592	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006593	Short C-terminal domain; Region: SHOCT; pfam09851
743722006594	Protein of unknown function, DUF481; Region: DUF481; cl01213
743722006595	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
743722006596	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743722006597	NAD binding site [chemical binding]; other site
743722006598	active site
743722006599	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722006600	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722006601	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
743722006602	PAP2 superfamily C-terminal; Region: PAP2_C; pfam14360
743722006603	META domain; Region: META; pfam03724
743722006604	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
743722006605	periplasmic chaperone; Provisional; Region: PRK10780
743722006606	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
743722006607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722006608	ATP binding site [chemical binding]; other site
743722006609	Mg2+ binding site [ion binding]; other site
743722006610	G-X-G motif; other site
743722006611	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
743722006612	anchoring element; other site
743722006613	dimer interface [polypeptide binding]; other site
743722006614	ATP binding site [chemical binding]; other site
743722006615	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
743722006616	active site
743722006617	putative metal-binding site [ion binding]; other site
743722006618	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
743722006619	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
743722006620	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
743722006621	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722006622	active site
743722006623	HIGH motif; other site
743722006624	nucleotide binding site [chemical binding]; other site
743722006625	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
743722006626	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
743722006627	active site
743722006628	KMSKS motif; other site
743722006629	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
743722006630	tRNA binding surface [nucleotide binding]; other site
743722006631	anticodon binding site; other site
743722006632	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
743722006633	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
743722006634	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
743722006635	DNA polymerase III, delta subunit; Region: holA; TIGR01128
743722006636	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722006637	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722006638	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
743722006639	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722006640	Walker A/P-loop; other site
743722006641	ATP binding site [chemical binding]; other site
743722006642	Q-loop/lid; other site
743722006643	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722006644	ABC transporter signature motif; other site
743722006645	Walker B; other site
743722006646	D-loop; other site
743722006647	ABC transporter; Region: ABC_tran_2; pfam12848
743722006648	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722006649	Predicted amidohydrolase [General function prediction only]; Region: COG0388
743722006650	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
743722006651	putative active site [active]
743722006652	catalytic triad [active]
743722006653	putative dimer interface [polypeptide binding]; other site
743722006654	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
743722006655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722006656	Walker A motif; other site
743722006657	ATP binding site [chemical binding]; other site
743722006658	Walker B motif; other site
743722006659	arginine finger; other site
743722006660	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
743722006661	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
743722006662	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722006663	Ligand binding site; other site
743722006664	Putative Catalytic site; other site
743722006665	DXD motif; other site
743722006666	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
743722006667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722006668	putative substrate translocation pore; other site
743722006669	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
743722006670	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722006671	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722006672	acetyl-CoA C-acetyltransferase; Region: PLN02644
743722006673	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
743722006674	dimer interface [polypeptide binding]; other site
743722006675	active site
743722006676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
743722006677	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
743722006678	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
743722006679	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
743722006680	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
743722006681	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722006682	Zn2+ binding site [ion binding]; other site
743722006683	Mg2+ binding site [ion binding]; other site
743722006684	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722006685	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722006686	NAD(P) binding site [chemical binding]; other site
743722006687	active site
743722006688	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722006689	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743722006690	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
743722006691	Inner membrane protein CreD; Region: CreD; pfam06123
743722006692	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
743722006693	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
743722006694	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722006695	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722006696	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722006697	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722006698	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722006699	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
743722006700	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722006701	Coenzyme A binding pocket [chemical binding]; other site
743722006702	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
743722006703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722006704	NAD(P) binding site [chemical binding]; other site
743722006705	active site
743722006706	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722006707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722006708	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722006709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722006710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722006711	DNA binding residues [nucleotide binding]
743722006712	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722006713	FecR protein; Region: FecR; pfam04773
743722006714	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006715	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006716	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722006717	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722006718	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722006719	SusD family; Region: SusD; pfam07980
743722006720	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722006721	active site
743722006722	metal binding site [ion binding]; metal-binding site
743722006723	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722006724	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722006725	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722006726	FecR protein; Region: FecR; pfam04773
743722006727	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722006728	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006729	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722006730	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722006731	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722006732	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722006733	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722006734	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
743722006735	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722006736	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722006737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722006738	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743722006739	Endonuclease I; Region: Endonuclease_1; cl01003
743722006740	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
743722006741	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
743722006742	heme-binding site [chemical binding]; other site
743722006743	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
743722006744	FAD binding pocket [chemical binding]; other site
743722006745	FAD binding motif [chemical binding]; other site
743722006746	phosphate binding motif [ion binding]; other site
743722006747	beta-alpha-beta structure motif; other site
743722006748	NAD binding pocket [chemical binding]; other site
743722006749	Heme binding  pocket [chemical binding]; other site
743722006750	Predicted transcriptional regulator [Transcription]; Region: COG1959
743722006751	Transcriptional regulator; Region: Rrf2; pfam02082
743722006752	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
743722006753	active site
743722006754	catalytic triad [active]
743722006755	oxyanion hole [active]
743722006756	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
743722006757	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
743722006758	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
743722006759	Predicted permeases [General function prediction only]; Region: COG0795
743722006760	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
743722006761	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
743722006762	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
743722006763	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722006764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722006765	active site
743722006766	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
743722006767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722006768	S-adenosylmethionine binding site [chemical binding]; other site
743722006769	DNA protecting protein DprA; Region: dprA; TIGR00732
743722006770	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
743722006771	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
743722006772	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
743722006773	Beta-Casp domain; Region: Beta-Casp; smart01027
743722006774	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
743722006775	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
743722006776	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722006777	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
743722006778	Walker A/P-loop; other site
743722006779	ATP binding site [chemical binding]; other site
743722006780	Q-loop/lid; other site
743722006781	ABC transporter signature motif; other site
743722006782	Walker B; other site
743722006783	D-loop; other site
743722006784	H-loop/switch region; other site
743722006785	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
743722006786	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
743722006787	PhoH-like protein; Region: PhoH; pfam02562
743722006788	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
743722006789	ATP binding site [chemical binding]; other site
743722006790	active site
743722006791	substrate binding site [chemical binding]; other site
743722006792	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
743722006793	anti sigma factor interaction site; other site
743722006794	regulatory phosphorylation site [posttranslational modification]; other site
743722006795	ribonuclease Z; Region: RNase_Z; TIGR02651
743722006796	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
743722006797	mce related protein; Region: MCE; pfam02470
743722006798	Proteins of 100 residues with WXG; Region: WXG100; cl02005
743722006799	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
743722006800	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
743722006801	active site
743722006802	metal binding site [ion binding]; metal-binding site
743722006803	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
743722006804	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
743722006805	active site
743722006806	metal binding site [ion binding]; metal-binding site
743722006807	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
743722006808	competence damage-inducible protein A; Provisional; Region: PRK00549
743722006809	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
743722006810	putative MPT binding site; other site
743722006811	Competence-damaged protein; Region: CinA; pfam02464
743722006812	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
743722006813	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722006814	E3 interaction surface; other site
743722006815	lipoyl attachment site [posttranslational modification]; other site
743722006816	e3 binding domain; Region: E3_binding; pfam02817
743722006817	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
743722006818	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
743722006819	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
743722006820	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
743722006821	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
743722006822	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
743722006823	RNA binding site [nucleotide binding]; other site
743722006824	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
743722006825	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
743722006826	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
743722006827	PspC domain; Region: PspC; cl00864
743722006828	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
743722006829	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006830	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722006831	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722006832	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006833	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
743722006834	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722006835	N-terminal plug; other site
743722006836	ligand-binding site [chemical binding]; other site
743722006837	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722006838	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
743722006839	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722006840	N-terminal plug; other site
743722006841	ligand-binding site [chemical binding]; other site
743722006842	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
743722006843	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
743722006844	active site
743722006845	Int/Topo IB signature motif; other site
743722006846	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
743722006847	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
743722006848	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
743722006849	NAD(P) binding site [chemical binding]; other site
743722006850	active site
743722006851	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
743722006852	Sel1-like repeats; Region: SEL1; smart00671
743722006853	Sel1-like repeats; Region: SEL1; smart00671
743722006854	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722006855	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722006856	active site
743722006857	metal binding site [ion binding]; metal-binding site
743722006858	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
743722006859	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722006860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722006861	active site
743722006862	phosphorylation site [posttranslational modification]
743722006863	intermolecular recognition site; other site
743722006864	dimerization interface [polypeptide binding]; other site
743722006865	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722006866	DNA binding site [nucleotide binding]
743722006867	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722006868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722006869	dimer interface [polypeptide binding]; other site
743722006870	phosphorylation site [posttranslational modification]
743722006871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722006872	ATP binding site [chemical binding]; other site
743722006873	Mg2+ binding site [ion binding]; other site
743722006874	G-X-G motif; other site
743722006875	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
743722006876	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
743722006877	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
743722006878	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
743722006879	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
743722006880	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
743722006881	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
743722006882	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
743722006883	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722006884	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722006885	dimer interface [polypeptide binding]; other site
743722006886	conserved gate region; other site
743722006887	putative PBP binding loops; other site
743722006888	ABC-ATPase subunit interface; other site
743722006889	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
743722006890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722006891	Walker A/P-loop; other site
743722006892	ATP binding site [chemical binding]; other site
743722006893	Q-loop/lid; other site
743722006894	ABC transporter signature motif; other site
743722006895	Walker B; other site
743722006896	D-loop; other site
743722006897	H-loop/switch region; other site
743722006898	mercuric reductase; Validated; Region: PRK06370
743722006899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722006900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722006901	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
743722006902	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
743722006903	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
743722006904	active site
743722006905	FMN binding site [chemical binding]; other site
743722006906	substrate binding site [chemical binding]; other site
743722006907	homotetramer interface [polypeptide binding]; other site
743722006908	catalytic residue [active]
743722006909	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722006910	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722006911	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722006912	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722006913	N-terminal plug; other site
743722006914	ligand-binding site [chemical binding]; other site
743722006915	Pectate lyase; Region: Pec_lyase_C; cl01593
743722006916	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
743722006917	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
743722006918	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
743722006919	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743722006920	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
743722006921	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
743722006922	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
743722006923	active site
743722006924	DNA binding site [nucleotide binding]
743722006925	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
743722006926	DNA binding site [nucleotide binding]
743722006927	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
743722006928	nucleotide binding site [chemical binding]; other site
743722006929	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722006930	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743722006931	putative hydrophobic ligand binding site [chemical binding]; other site
743722006932	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743722006933	putative hydrophobic ligand binding site [chemical binding]; other site
743722006934	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
743722006935	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
743722006936	conserved cys residue [active]
743722006937	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722006938	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722006939	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
743722006940	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
743722006941	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
743722006942	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
743722006943	[2Fe-2S] cluster binding site [ion binding]; other site
743722006944	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
743722006945	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
743722006946	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
743722006947	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
743722006948	MerC mercury resistance protein; Region: MerC; pfam03203
743722006949	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722006950	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
743722006951	Walker A/P-loop; other site
743722006952	ATP binding site [chemical binding]; other site
743722006953	Q-loop/lid; other site
743722006954	ABC transporter signature motif; other site
743722006955	Walker B; other site
743722006956	D-loop; other site
743722006957	H-loop/switch region; other site
743722006958	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722006959	FtsX-like permease family; Region: FtsX; pfam02687
743722006960	Protein of unknown function (DUF3299); Region: DUF3299; cl01387
743722006961	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722006962	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
743722006963	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
743722006964	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
743722006965	dimer interface [polypeptide binding]; other site
743722006966	active site
743722006967	heme binding site [chemical binding]; other site
743722006968	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
743722006969	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743722006970	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722006971	putative Zn2+ binding site [ion binding]; other site
743722006972	putative DNA binding site [nucleotide binding]; other site
743722006973	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743722006974	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722006975	Coenzyme A binding pocket [chemical binding]; other site
743722006976	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
743722006977	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722006978	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722006979	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722006980	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722006981	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
743722006982	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
743722006983	RNAase interaction site [polypeptide binding]; other site
743722006984	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
743722006985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722006986	active site
743722006987	motif I; other site
743722006988	motif II; other site
743722006989	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
743722006990	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
743722006991	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
743722006992	active site
743722006993	homotetramer interface [polypeptide binding]; other site
743722006994	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
743722006995	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
743722006996	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
743722006997	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
743722006998	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722006999	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722007000	FtsX-like permease family; Region: FtsX; pfam02687
743722007001	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722007002	FtsX-like permease family; Region: FtsX; pfam02687
743722007003	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722007004	Coenzyme A binding pocket [chemical binding]; other site
743722007005	Pirin-related protein [General function prediction only]; Region: COG1741
743722007006	Pirin; Region: Pirin; pfam02678
743722007007	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
743722007008	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722007009	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722007010	ligand binding site [chemical binding]; other site
743722007011	flexible hinge region; other site
743722007012	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
743722007013	Predicted flavoprotein [General function prediction only]; Region: COG0431
743722007014	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722007015	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722007016	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
743722007017	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722007018	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
743722007019	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
743722007020	hexamer (dimer of trimers) interface [polypeptide binding]; other site
743722007021	substrate binding site [chemical binding]; other site
743722007022	trimer interface [polypeptide binding]; other site
743722007023	Mn binding site [ion binding]; other site
743722007024	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
743722007025	transketolase; Reviewed; Region: PRK05899
743722007026	TPP-binding site [chemical binding]; other site
743722007027	dimer interface [polypeptide binding]; other site
743722007028	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
743722007029	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743722007030	PYR/PP interface [polypeptide binding]; other site
743722007031	dimer interface [polypeptide binding]; other site
743722007032	TPP binding site [chemical binding]; other site
743722007033	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722007034	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
743722007035	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
743722007036	ligand binding site [chemical binding]; other site
743722007037	dimerization interface [polypeptide binding]; other site
743722007038	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
743722007039	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
743722007040	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
743722007041	Walker A/P-loop; other site
743722007042	ATP binding site [chemical binding]; other site
743722007043	Q-loop/lid; other site
743722007044	ABC transporter signature motif; other site
743722007045	Walker B; other site
743722007046	D-loop; other site
743722007047	H-loop/switch region; other site
743722007048	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
743722007049	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743722007050	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
743722007051	TM-ABC transporter signature motif; other site
743722007052	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
743722007053	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722007054	nucleotide binding site [chemical binding]; other site
743722007055	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
743722007056	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722007057	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722007058	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722007059	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722007060	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
743722007061	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007062	putative substrate translocation pore; other site
743722007063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722007064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722007065	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007066	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007067	SusD family; Region: SusD; pfam07980
743722007068	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007069	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007070	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007071	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007072	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
743722007073	Short C-terminal domain; Region: SHOCT; pfam09851
743722007074	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722007075	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
743722007076	Sodium Bile acid symporter family; Region: SBF; pfam01758
743722007077	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
743722007078	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
743722007079	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
743722007080	active site pocket [active]
743722007081	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
743722007082	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
743722007083	dimer interface [polypeptide binding]; other site
743722007084	NADP binding site [chemical binding]; other site
743722007085	catalytic residues [active]
743722007086	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
743722007087	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007088	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007089	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007090	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722007091	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007092	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722007093	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722007095	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722007096	dimer interface [polypeptide binding]; other site
743722007097	phosphorylation site [posttranslational modification]
743722007098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722007099	ATP binding site [chemical binding]; other site
743722007100	Mg2+ binding site [ion binding]; other site
743722007101	G-X-G motif; other site
743722007102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722007103	Response regulator receiver domain; Region: Response_reg; pfam00072
743722007104	active site
743722007105	phosphorylation site [posttranslational modification]
743722007106	intermolecular recognition site; other site
743722007107	dimerization interface [polypeptide binding]; other site
743722007108	Transcriptional regulator; Region: Rrf2; cl17282
743722007109	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722007110	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
743722007111	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
743722007112	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743722007113	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743722007114	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743722007115	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
743722007116	inhibitor binding site; inhibition site
743722007117	active site
743722007118	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
743722007119	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
743722007120	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
743722007121	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007122	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007123	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007124	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007125	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007126	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007127	SusD family; Region: SusD; pfam07980
743722007128	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
743722007129	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743722007130	active site
743722007131	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
743722007132	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743722007133	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
743722007134	inhibitor binding site; inhibition site
743722007135	active site
743722007136	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
743722007137	Putative esterase; Region: Esterase; pfam00756
743722007138	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722007139	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007140	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007141	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722007142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722007143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722007144	dimer interface [polypeptide binding]; other site
743722007145	phosphorylation site [posttranslational modification]
743722007146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722007147	ATP binding site [chemical binding]; other site
743722007148	Mg2+ binding site [ion binding]; other site
743722007149	G-X-G motif; other site
743722007150	Response regulator receiver domain; Region: Response_reg; pfam00072
743722007151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722007152	active site
743722007153	phosphorylation site [posttranslational modification]
743722007154	intermolecular recognition site; other site
743722007155	dimerization interface [polypeptide binding]; other site
743722007156	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722007157	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007158	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
743722007159	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722007160	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722007161	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722007162	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
743722007163	substrate binding site [chemical binding]; other site
743722007164	active site
743722007165	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007166	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007167	SusD family; Region: SusD; pfam07980
743722007168	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007169	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007170	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007171	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007172	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
743722007173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722007174	S-adenosylmethionine binding site [chemical binding]; other site
743722007175	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
743722007176	trimer interface [polypeptide binding]; other site
743722007177	putative Zn binding site [ion binding]; other site
743722007178	Uncharacterized conserved protein [Function unknown]; Region: COG1359
743722007179	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
743722007180	Outer membrane efflux protein; Region: OEP; pfam02321
743722007181	Outer membrane efflux protein; Region: OEP; pfam02321
743722007182	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
743722007183	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722007184	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722007185	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722007186	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722007187	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722007188	catalytic residues [active]
743722007189	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
743722007190	PA_GCPII_like: Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to...; Region: PA_GCPII_like; cd02121
743722007191	apical/protease domain interface [polypeptide binding]; other site
743722007192	substrate binding [chemical binding]; other site
743722007193	dimer interface [polypeptide binding]; other site
743722007194	M28 Zn-peptidase prostate-specific membrane antigen; Region: M28_PSMA_like; cd08022
743722007195	dimer interface [polypeptide binding]; other site
743722007196	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722007197	active site
743722007198	metal binding site [ion binding]; metal-binding site
743722007199	Transferrin receptor-like dimerisation domain; Region: TFR_dimer; pfam04253
743722007200	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722007201	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007202	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
743722007203	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007204	putative substrate translocation pore; other site
743722007205	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743722007206	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
743722007207	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722007208	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722007209	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722007210	N-terminal plug; other site
743722007211	ligand-binding site [chemical binding]; other site
743722007212	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007213	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007214	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722007215	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722007216	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722007217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007218	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
743722007219	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722007220	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007221	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722007222	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722007223	N-terminal plug; other site
743722007224	ligand-binding site [chemical binding]; other site
743722007225	nucleoside transporter; Region: 2A0110; TIGR00889
743722007226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007227	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
743722007228	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
743722007229	GTP binding site; other site
743722007230	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
743722007231	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722007232	active site
743722007233	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
743722007234	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
743722007235	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
743722007236	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722007237	motif II; other site
743722007238	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
743722007239	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
743722007240	gating phenylalanine in ion channel; other site
743722007241	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
743722007242	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
743722007243	[4Fe-4S] binding site [ion binding]; other site
743722007244	molybdopterin cofactor binding site; other site
743722007245	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
743722007246	molybdopterin cofactor binding site; other site
743722007247	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
743722007248	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
743722007249	iron-sulfur cluster [ion binding]; other site
743722007250	[2Fe-2S] cluster binding site [ion binding]; other site
743722007251	Predicted acetyltransferase [General function prediction only]; Region: COG2388
743722007252	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
743722007253	Glyco_18 domain; Region: Glyco_18; smart00636
743722007254	active site
743722007255	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
743722007256	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
743722007257	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
743722007258	Sulfate transporter family; Region: Sulfate_transp; pfam00916
743722007259	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
743722007260	short chain dehydrogenase; Provisional; Region: PRK08339
743722007261	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
743722007262	putative NAD(P) binding site [chemical binding]; other site
743722007263	putative active site [active]
743722007264	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722007265	Ligand Binding Site [chemical binding]; other site
743722007266	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
743722007267	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
743722007268	putative active site [active]
743722007269	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
743722007270	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
743722007271	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
743722007272	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
743722007273	hypothetical protein; Provisional; Region: PRK06753
743722007274	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722007275	hypothetical protein; Provisional; Region: PRK07236
743722007276	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743722007277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722007278	S-adenosylmethionine binding site [chemical binding]; other site
743722007279	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
743722007280	active site
743722007281	8-oxo-dGMP binding site [chemical binding]; other site
743722007282	nudix motif; other site
743722007283	metal binding site [ion binding]; metal-binding site
743722007284	Predicted membrane protein [Function unknown]; Region: COG1470
743722007285	NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633
743722007286	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743722007287	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743722007288	Walker A/P-loop; other site
743722007289	ATP binding site [chemical binding]; other site
743722007290	Q-loop/lid; other site
743722007291	ABC transporter signature motif; other site
743722007292	Walker B; other site
743722007293	D-loop; other site
743722007294	H-loop/switch region; other site
743722007295	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
743722007296	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
743722007297	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
743722007298	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
743722007299	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
743722007300	active site
743722007301	DNA binding site [nucleotide binding]
743722007302	DNA helicase, putative; Region: TIGR00376
743722007303	AAA domain; Region: AAA_12; pfam13087
743722007304	Patatin-like phospholipase; Region: Patatin; pfam01734
743722007305	active site
743722007306	nucleophile elbow; other site
743722007307	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
743722007308	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
743722007309	Mg2+ binding site [ion binding]; other site
743722007310	G-X-G motif; other site
743722007311	EcsC protein family; Region: EcsC; pfam12787
743722007312	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722007313	Ligand Binding Site [chemical binding]; other site
743722007314	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722007315	Ligand Binding Site [chemical binding]; other site
743722007316	DinB family; Region: DinB; cl17821
743722007317	DinB superfamily; Region: DinB_2; pfam12867
743722007318	Predicted transcriptional regulator [Transcription]; Region: COG2378
743722007319	HTH domain; Region: HTH_11; pfam08279
743722007320	WYL domain; Region: WYL; pfam13280
743722007321	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722007322	S-adenosylmethionine binding site [chemical binding]; other site
743722007323	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722007324	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722007325	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
743722007326	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743722007327	Methane oxygenase PmoA; Region: PmoA; pfam14100
743722007328	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722007329	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722007330	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722007331	Transcriptional regulators [Transcription]; Region: FadR; COG2186
743722007332	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722007333	DNA-binding site [nucleotide binding]; DNA binding site
743722007334	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
743722007335	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
743722007336	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722007337	putative DNA binding site [nucleotide binding]; other site
743722007338	putative Zn2+ binding site [ion binding]; other site
743722007339	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
743722007340	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722007341	Coenzyme A binding pocket [chemical binding]; other site
743722007342	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007343	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007344	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007345	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007346	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
743722007347	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007348	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007349	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007350	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007351	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; cl15276
743722007352	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743722007353	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
743722007354	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722007355	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
743722007356	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722007357	MG2 domain; Region: A2M_N; pfam01835
743722007358	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722007359	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722007360	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
743722007361	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743722007362	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722007363	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722007364	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722007365	active site
743722007366	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722007367	catalytic tetrad [active]
743722007368	Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999
743722007369	active site
743722007370	Mn binding site [ion binding]; other site
743722007371	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743722007372	active site
743722007373	Zn binding site [ion binding]; other site
743722007374	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722007375	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722007376	DNA binding residues [nucleotide binding]
743722007377	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
743722007378	Trp docking motif [polypeptide binding]; other site
743722007379	PQQ-like domain; Region: PQQ_2; pfam13360
743722007380	putative active site [active]
743722007381	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
743722007382	Cytochrome c; Region: Cytochrom_C; pfam00034
743722007383	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
743722007384	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007385	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007386	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007387	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007388	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722007389	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007390	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
743722007391	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
743722007392	active site pocket [active]
743722007393	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722007394	FecR protein; Region: FecR; pfam04773
743722007395	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
743722007396	D-galactonate transporter; Region: 2A0114; TIGR00893
743722007397	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007398	putative substrate translocation pore; other site
743722007399	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722007400	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
743722007401	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722007402	N-terminal plug; other site
743722007403	ligand-binding site [chemical binding]; other site
743722007404	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
743722007405	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
743722007406	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722007407	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722007408	active site
743722007409	catalytic tetrad [active]
743722007410	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722007411	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722007412	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722007413	DNA binding residues [nucleotide binding]
743722007414	FecR protein; Region: FecR; pfam04773
743722007415	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722007416	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722007417	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007418	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007419	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007420	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007421	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007422	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722007423	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
743722007424	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007425	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722007426	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
743722007427	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743722007428	DNA binding site [nucleotide binding]
743722007429	active site
743722007430	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722007431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007432	putative substrate translocation pore; other site
743722007433	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007434	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743722007435	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722007436	putative DNA binding site [nucleotide binding]; other site
743722007437	putative Zn2+ binding site [ion binding]; other site
743722007438	AsnC family; Region: AsnC_trans_reg; pfam01037
743722007439	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
743722007440	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
743722007441	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
743722007442	putative hydrophobic ligand binding site [chemical binding]; other site
743722007443	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
743722007444	putative hydrophobic ligand binding site [chemical binding]; other site
743722007445	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722007446	dimerization interface [polypeptide binding]; other site
743722007447	putative DNA binding site [nucleotide binding]; other site
743722007448	putative Zn2+ binding site [ion binding]; other site
743722007449	DinB superfamily; Region: DinB_2; pfam12867
743722007450	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743722007451	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
743722007452	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722007453	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722007454	active site
743722007455	metal binding site [ion binding]; metal-binding site
743722007456	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
743722007457	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
743722007458	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722007459	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722007460	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722007461	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722007462	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722007463	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722007464	Outer membrane efflux protein; Region: OEP; pfam02321
743722007465	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722007466	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722007467	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722007468	Predicted acyl esterases [General function prediction only]; Region: COG2936
743722007469	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722007470	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
743722007471	HSP90 family protein; Provisional; Region: PRK14083
743722007472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
743722007473	ATP binding site [chemical binding]; other site
743722007474	Mg2+ binding site [ion binding]; other site
743722007475	G-X-G motif; other site
743722007476	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
743722007477	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
743722007478	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
743722007479	Sel1 repeat; Region: Sel1; pfam08238
743722007480	Sel1-like repeats; Region: SEL1; smart00671
743722007481	Sel1-like repeats; Region: SEL1; smart00671
743722007482	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722007483	Clp protease; Region: CLP_protease; pfam00574
743722007484	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743722007485	oligomer interface [polypeptide binding]; other site
743722007486	active site residues [active]
743722007487	Methyltransferase domain; Region: Methyltransf_23; pfam13489
743722007488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722007489	S-adenosylmethionine binding site [chemical binding]; other site
743722007490	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743722007491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722007492	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
743722007493	dimerization interface [polypeptide binding]; other site
743722007494	substrate binding pocket [chemical binding]; other site
743722007495	Uncharacterized conserved protein [Function unknown]; Region: COG3538
743722007496	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
743722007497	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
743722007498	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743722007499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722007500	Coenzyme A binding pocket [chemical binding]; other site
743722007501	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722007502	Predicted membrane protein [Function unknown]; Region: COG2246
743722007503	GtrA-like protein; Region: GtrA; pfam04138
743722007504	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
743722007505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722007506	Coenzyme A binding pocket [chemical binding]; other site
743722007507	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942
743722007508	aromatic arch; other site
743722007509	DCoH dimer interaction site [polypeptide binding]; other site
743722007510	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
743722007511	DCoH tetramer interaction site [polypeptide binding]; other site
743722007512	substrate binding site [chemical binding]; other site
743722007513	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722007514	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
743722007515	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722007516	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722007517	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722007518	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722007519	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722007520	WHG domain; Region: WHG; pfam13305
743722007521	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743722007522	NlpC/P60 family; Region: NLPC_P60; pfam00877
743722007523	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743722007524	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743722007525	substrate binding site [chemical binding]; other site
743722007526	ATP binding site [chemical binding]; other site
743722007527	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722007528	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722007529	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722007530	DNA binding residues [nucleotide binding]
743722007531	FecR protein; Region: FecR; pfam04773
743722007532	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722007533	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007534	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007535	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007536	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007537	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007538	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
743722007539	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743722007540	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743722007541	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722007542	DNA binding site [nucleotide binding]
743722007543	domain linker motif; other site
743722007544	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
743722007545	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
743722007546	ligand binding site [chemical binding]; other site
743722007547	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722007548	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722007549	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
743722007550	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722007551	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007552	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007553	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007554	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722007555	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007556	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007557	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007558	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722007559	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722007560	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722007561	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007562	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
743722007563	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
743722007564	active site
743722007565	dimer interface [polypeptide binding]; other site
743722007566	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722007567	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722007568	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722007569	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722007570	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722007571	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722007572	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743722007573	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
743722007574	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
743722007575	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
743722007576	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
743722007577	active site
743722007578	catalytic triad [active]
743722007579	oxyanion hole [active]
743722007580	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722007581	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722007582	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
743722007583	metal binding site [ion binding]; metal-binding site
743722007584	substrate binding pocket [chemical binding]; other site
743722007585	Class I aldolases; Region: Aldolase_Class_I; cl17187
743722007586	catalytic residue [active]
743722007587	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722007588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722007589	NAD(P) binding site [chemical binding]; other site
743722007590	active site
743722007591	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
743722007592	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
743722007593	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007594	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007595	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007596	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007597	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007598	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
743722007599	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
743722007600	putative dimer interface [polypeptide binding]; other site
743722007601	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
743722007602	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
743722007603	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722007604	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
743722007605	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007606	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007607	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007608	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
743722007609	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007610	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
743722007611	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722007612	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722007613	beta-D-glucuronidase; Provisional; Region: PRK10150
743722007614	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722007615	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722007616	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
743722007617	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
743722007618	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
743722007619	Alginate lyase; Region: Alginate_lyase; pfam05426
743722007620	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
743722007621	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722007622	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722007623	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722007624	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007625	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007626	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007627	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007628	Two component regulator propeller; Region: Reg_prop; pfam07494
743722007629	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722007630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722007631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722007632	dimer interface [polypeptide binding]; other site
743722007633	phosphorylation site [posttranslational modification]
743722007634	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722007635	ATP binding site [chemical binding]; other site
743722007636	Mg2+ binding site [ion binding]; other site
743722007637	G-X-G motif; other site
743722007638	Response regulator receiver domain; Region: Response_reg; pfam00072
743722007639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722007640	active site
743722007641	phosphorylation site [posttranslational modification]
743722007642	intermolecular recognition site; other site
743722007643	dimerization interface [polypeptide binding]; other site
743722007644	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722007645	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007646	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722007647	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722007648	active site
743722007649	catalytic tetrad [active]
743722007650	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722007651	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722007652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722007653	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722007654	active site
743722007655	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
743722007656	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821
743722007657	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
743722007658	dimer interface [polypeptide binding]; other site
743722007659	active site
743722007660	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743722007661	substrate binding site [chemical binding]; other site
743722007662	catalytic residue [active]
743722007663	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
743722007664	homotrimer interaction site [polypeptide binding]; other site
743722007665	putative active site [active]
743722007666	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743722007667	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722007668	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722007669	DNA binding site [nucleotide binding]
743722007670	domain linker motif; other site
743722007671	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722007672	ligand binding site [chemical binding]; other site
743722007673	dimerization interface [polypeptide binding]; other site
743722007674	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
743722007675	active site
743722007676	catalytic triad [active]
743722007677	Pectinesterase; Region: Pectinesterase; pfam01095
743722007678	putative pectinesterase; Region: PLN02432; cl01911
743722007679	Pectic acid lyase; Region: Pec_lyase; pfam09492
743722007680	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743722007681	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
743722007682	active site
743722007683	Pectinesterase; Region: Pectinesterase; pfam01095
743722007684	putative pectinesterase; Region: PLN02432; cl01911
743722007685	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007686	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007687	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007688	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007689	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007690	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007691	SusD family; Region: SusD; pfam07980
743722007692	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007693	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007694	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007695	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007696	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007697	SusD family; Region: SusD; pfam07980
743722007698	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
743722007699	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
743722007700	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722007701	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
743722007702	altronate oxidoreductase; Provisional; Region: PRK03643
743722007703	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
743722007704	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
743722007705	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
743722007706	galactarate dehydratase; Region: galactar-dH20; TIGR03248
743722007707	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
743722007708	Glucuronate isomerase; Region: UxaC; pfam02614
743722007709	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
743722007710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007711	putative substrate translocation pore; other site
743722007712	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722007713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722007714	putative substrate translocation pore; other site
743722007715	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722007716	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722007717	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722007718	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
743722007719	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
743722007720	dimer interface [polypeptide binding]; other site
743722007721	active site
743722007722	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
743722007723	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
743722007724	putative ligand binding site [chemical binding]; other site
743722007725	putative NAD binding site [chemical binding]; other site
743722007726	catalytic site [active]
743722007727	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
743722007728	putative active site [active]
743722007729	putative metal binding site [ion binding]; other site
743722007730	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722007731	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743722007732	active site
743722007733	catalytic triad [active]
743722007734	oxyanion hole [active]
743722007735	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
743722007736	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
743722007737	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
743722007738	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
743722007739	active site
743722007740	catalytic site [active]
743722007741	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007742	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007743	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007744	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007745	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007746	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722007747	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722007748	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722007749	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
743722007750	amphipathic channel; other site
743722007751	Asn-Pro-Ala signature motifs; other site
743722007752	glycerol kinase; Provisional; Region: glpK; PRK00047
743722007753	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
743722007754	N- and C-terminal domain interface [polypeptide binding]; other site
743722007755	active site
743722007756	MgATP binding site [chemical binding]; other site
743722007757	catalytic site [active]
743722007758	metal binding site [ion binding]; metal-binding site
743722007759	glycerol binding site [chemical binding]; other site
743722007760	homotetramer interface [polypeptide binding]; other site
743722007761	homodimer interface [polypeptide binding]; other site
743722007762	FBP binding site [chemical binding]; other site
743722007763	protein IIAGlc interface [polypeptide binding]; other site
743722007764	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
743722007765	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722007766	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
743722007767	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722007768	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722007769	catalytic residues [active]
743722007770	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
743722007771	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632
743722007772	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
743722007773	Class I ribonucleotide reductase; Region: RNR_I; cd01679
743722007774	active site
743722007775	dimer interface [polypeptide binding]; other site
743722007776	catalytic residues [active]
743722007777	effector binding site; other site
743722007778	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
743722007779	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
743722007780	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
743722007781	dimer interface [polypeptide binding]; other site
743722007782	putative radical transfer pathway; other site
743722007783	diiron center [ion binding]; other site
743722007784	tyrosyl radical; other site
743722007785	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
743722007786	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
743722007787	GH3 auxin-responsive promoter; Region: GH3; pfam03321
743722007788	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
743722007789	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
743722007790	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
743722007791	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
743722007792	RIP metalloprotease RseP; Region: TIGR00054
743722007793	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
743722007794	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
743722007795	protein binding site [polypeptide binding]; other site
743722007796	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
743722007797	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
743722007798	putative substrate binding region [chemical binding]; other site
743722007799	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722007800	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
743722007801	CheB methylesterase; Region: CheB_methylest; pfam01339
743722007802	trigger factor; Region: tig; TIGR00115
743722007803	Clp protease; Region: CLP_protease; pfam00574
743722007804	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
743722007805	oligomer interface [polypeptide binding]; other site
743722007806	active site residues [active]
743722007807	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
743722007808	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
743722007809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722007810	Walker A motif; other site
743722007811	ATP binding site [chemical binding]; other site
743722007812	Walker B motif; other site
743722007813	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
743722007814	AMP nucleosidase; Provisional; Region: PRK07115
743722007815	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
743722007816	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
743722007817	dimer interface [polypeptide binding]; other site
743722007818	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722007819	catalytic residue [active]
743722007820	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
743722007821	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
743722007822	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
743722007823	hinge; other site
743722007824	active site
743722007825	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
743722007826	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
743722007827	Part of AAA domain; Region: AAA_19; pfam13245
743722007828	Family description; Region: UvrD_C_2; pfam13538
743722007829	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722007830	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
743722007831	nudix motif; other site
743722007832	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
743722007833	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
743722007834	Competence protein; Region: Competence; pfam03772
743722007835	helicase 45; Provisional; Region: PTZ00424
743722007836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722007837	ATP binding site [chemical binding]; other site
743722007838	putative Mg++ binding site [ion binding]; other site
743722007839	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722007840	nucleotide binding region [chemical binding]; other site
743722007841	ATP-binding site [chemical binding]; other site
743722007842	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722007843	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722007844	DNA binding residues [nucleotide binding]
743722007845	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722007846	FecR protein; Region: FecR; pfam04773
743722007847	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007848	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007849	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007850	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007851	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007852	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722007853	SusD family; Region: SusD; pfam07980
743722007854	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
743722007855	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743722007856	Cysteine-rich domain; Region: CCG; pfam02754
743722007857	Cysteine-rich domain; Region: CCG; pfam02754
743722007858	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722007859	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722007860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722007861	DNA binding residues [nucleotide binding]
743722007862	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722007863	FecR protein; Region: FecR; pfam04773
743722007864	Secretin and TonB N terminus short domain; Region: STN; smart00965
743722007865	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007866	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007867	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007868	SusD family; Region: SusD; pfam07980
743722007869	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007870	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007871	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007872	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007873	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722007874	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007875	SusD family; Region: SusD; pfam07980
743722007876	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722007877	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
743722007878	Metal-binding active site; metal-binding site
743722007879	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722007880	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722007881	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
743722007882	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722007883	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722007884	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722007885	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722007886	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722007887	DNA binding residues [nucleotide binding]
743722007888	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722007889	FecR protein; Region: FecR; pfam04773
743722007890	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722007891	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722007892	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722007893	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722007894	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722007895	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722007896	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722007897	dihydroorotase; Provisional; Region: PRK09237
743722007898	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722007899	active site
743722007900	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743722007901	homotrimer interaction site [polypeptide binding]; other site
743722007902	putative active site [active]
743722007903	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
743722007904	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
743722007905	Sodium Bile acid symporter family; Region: SBF; cl17470
743722007906	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
743722007907	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722007908	catalytic residue [active]
743722007909	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
743722007910	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
743722007911	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
743722007912	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
743722007913	active site
743722007914	dimer interface [polypeptide binding]; other site
743722007915	motif 1; other site
743722007916	motif 2; other site
743722007917	motif 3; other site
743722007918	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
743722007919	anticodon binding site; other site
743722007920	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
743722007921	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
743722007922	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
743722007923	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
743722007924	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
743722007925	23S rRNA binding site [nucleotide binding]; other site
743722007926	L21 binding site [polypeptide binding]; other site
743722007927	L13 binding site [polypeptide binding]; other site
743722007928	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
743722007929	active site
743722007930	catalytic residues [active]
743722007931	metal binding site [ion binding]; metal-binding site
743722007932	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
743722007933	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722007934	catalytic loop [active]
743722007935	iron binding site [ion binding]; other site
743722007936	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
743722007937	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722007938	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722007939	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722007940	MarR family; Region: MarR_2; pfam12802
743722007941	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
743722007942	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
743722007943	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
743722007944	Protein export membrane protein; Region: SecD_SecF; pfam02355
743722007945	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743722007946	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
743722007947	folate binding site [chemical binding]; other site
743722007948	NADP+ binding site [chemical binding]; other site
743722007949	thymidylate synthase; Reviewed; Region: thyA; PRK01827
743722007950	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
743722007951	dimerization interface [polypeptide binding]; other site
743722007952	active site
743722007953	Immunoglobulin domain; Region: Ig_2; pfam13895
743722007954	Domain of unknown function DUF11; Region: DUF11; pfam01345
743722007955	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
743722007956	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
743722007957	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
743722007958	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722007959	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
743722007960	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
743722007961	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
743722007962	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
743722007963	NAD(P) binding site [chemical binding]; other site
743722007964	Found in ATP-dependent protease La (LON); Region: LON; smart00464
743722007965	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
743722007966	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722007967	Walker A motif; other site
743722007968	ATP binding site [chemical binding]; other site
743722007969	Walker B motif; other site
743722007970	arginine finger; other site
743722007971	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
743722007972	TPR repeat; Region: TPR_11; pfam13414
743722007973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722007974	TPR motif; other site
743722007975	binding surface
743722007976	TPR repeat; Region: TPR_11; pfam13414
743722007977	phosphoglyceromutase; Provisional; Region: PRK05434
743722007978	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
743722007979	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
743722007980	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
743722007981	dimerization interface [polypeptide binding]; other site
743722007982	active site
743722007983	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
743722007984	Peptidase family M48; Region: Peptidase_M48; pfam01435
743722007985	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
743722007986	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
743722007987	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
743722007988	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
743722007989	GDP-binding site [chemical binding]; other site
743722007990	ACT binding site; other site
743722007991	IMP binding site; other site
743722007992	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
743722007993	metal binding site 2 [ion binding]; metal-binding site
743722007994	putative DNA binding helix; other site
743722007995	metal binding site 1 [ion binding]; metal-binding site
743722007996	dimer interface [polypeptide binding]; other site
743722007997	structural Zn2+ binding site [ion binding]; other site
743722007998	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
743722007999	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722008000	Zn2+ binding site [ion binding]; other site
743722008001	Mg2+ binding site [ion binding]; other site
743722008002	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
743722008003	synthetase active site [active]
743722008004	NTP binding site [chemical binding]; other site
743722008005	metal binding site [ion binding]; metal-binding site
743722008006	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
743722008007	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
743722008008	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
743722008009	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
743722008010	catalytic residues [active]
743722008011	dimer interface [polypeptide binding]; other site
743722008012	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
743722008013	acyl-coenzyme A oxidase; Region: PLN02526
743722008014	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743722008015	active site
743722008016	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
743722008017	NAD(P) binding site [chemical binding]; other site
743722008018	4Fe-4S binding domain; Region: Fer4; pfam00037
743722008019	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722008020	Ligand Binding Site [chemical binding]; other site
743722008021	Bacterial SH3 domain; Region: SH3_3; cl17532
743722008022	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743722008023	NlpC/P60 family; Region: NLPC_P60; pfam00877
743722008024	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
743722008025	dimer interface [polypeptide binding]; other site
743722008026	active site
743722008027	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743722008028	catalytic residues [active]
743722008029	substrate binding site [chemical binding]; other site
743722008030	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
743722008031	Amidinotransferase; Region: Amidinotransf; pfam02274
743722008032	Amidinotransferase; Region: Amidinotransf; cl12043
743722008033	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
743722008034	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
743722008035	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
743722008036	active site
743722008037	HIGH motif; other site
743722008038	nucleotide binding site [chemical binding]; other site
743722008039	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
743722008040	KMSK motif region; other site
743722008041	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
743722008042	tRNA binding surface [nucleotide binding]; other site
743722008043	anticodon binding site; other site
743722008044	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
743722008045	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722008046	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
743722008047	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509
743722008048	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
743722008049	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
743722008050	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
743722008051	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
743722008052	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
743722008053	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
743722008054	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743722008055	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722008056	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
743722008057	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
743722008058	active site
743722008059	substrate-binding site [chemical binding]; other site
743722008060	metal-binding site [ion binding]
743722008061	ATP binding site [chemical binding]; other site
743722008062	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743722008063	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722008064	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
743722008065	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
743722008066	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
743722008067	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722008068	catalytic residue [active]
743722008069	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
743722008070	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
743722008071	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
743722008072	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
743722008073	Cl- selectivity filter; other site
743722008074	Cl- binding residues [ion binding]; other site
743722008075	pore gating glutamate residue; other site
743722008076	dimer interface [polypeptide binding]; other site
743722008077	FOG: CBS domain [General function prediction only]; Region: COG0517
743722008078	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
743722008079	Late embryogenesis abundant protein; Region: LEA_2; pfam03168
743722008080	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722008081	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722008082	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722008083	MarR family; Region: MarR_2; pfam12802
743722008084	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
743722008085	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
743722008086	substrate-cofactor binding pocket; other site
743722008087	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722008088	catalytic residue [active]
743722008089	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008090	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
743722008091	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
743722008092	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
743722008093	Predicted membrane protein [Function unknown]; Region: COG2246
743722008094	GtrA-like protein; Region: GtrA; pfam04138
743722008095	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722008096	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722008097	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
743722008098	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
743722008099	GAF domain; Region: GAF_2; pfam13185
743722008100	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
743722008101	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
743722008102	putative active site [active]
743722008103	Zn binding site [ion binding]; other site
743722008104	Putative esterase; Region: Esterase; pfam00756
743722008105	S-formylglutathione hydrolase; Region: PLN02442
743722008106	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
743722008107	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
743722008108	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
743722008109	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
743722008110	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
743722008111	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
743722008112	putative trimer interface [polypeptide binding]; other site
743722008113	putative CoA binding site [chemical binding]; other site
743722008114	triosephosphate isomerase; Provisional; Region: PRK14567
743722008115	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
743722008116	substrate binding site [chemical binding]; other site
743722008117	dimer interface [polypeptide binding]; other site
743722008118	catalytic triad [active]
743722008119	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
743722008120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722008121	S-adenosylmethionine binding site [chemical binding]; other site
743722008122	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
743722008123	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743722008124	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722008125	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
743722008126	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743722008127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722008128	non-specific DNA binding site [nucleotide binding]; other site
743722008129	salt bridge; other site
743722008130	sequence-specific DNA binding site [nucleotide binding]; other site
743722008131	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
743722008132	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
743722008133	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722008134	FeS/SAM binding site; other site
743722008135	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
743722008136	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
743722008137	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
743722008138	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722008139	FeS/SAM binding site; other site
743722008140	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743722008141	NlpC/P60 family; Region: NLPC_P60; pfam00877
743722008142	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
743722008143	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743722008144	active site
743722008145	catalytic site [active]
743722008146	substrate binding site [chemical binding]; other site
743722008147	replicative DNA helicase; Region: DnaB; TIGR00665
743722008148	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
743722008149	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
743722008150	Walker A motif; other site
743722008151	ATP binding site [chemical binding]; other site
743722008152	Walker B motif; other site
743722008153	DNA binding loops [nucleotide binding]
743722008154	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
743722008155	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
743722008156	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743722008157	nucleoside transporter; Region: 2A0110; TIGR00889
743722008158	Bifunctional nuclease; Region: DNase-RNase; pfam02577
743722008159	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
743722008160	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
743722008161	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
743722008162	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
743722008163	Ligand binding site [chemical binding]; other site
743722008164	Electron transfer flavoprotein domain; Region: ETF; pfam01012
743722008165	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722008166	TPR motif; other site
743722008167	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722008168	binding surface
743722008169	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
743722008170	MutS domain I; Region: MutS_I; pfam01624
743722008171	MutS domain II; Region: MutS_II; pfam05188
743722008172	MutS domain III; Region: MutS_III; pfam05192
743722008173	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
743722008174	Walker A/P-loop; other site
743722008175	ATP binding site [chemical binding]; other site
743722008176	Q-loop/lid; other site
743722008177	ABC transporter signature motif; other site
743722008178	Walker B; other site
743722008179	D-loop; other site
743722008180	H-loop/switch region; other site
743722008181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722008182	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
743722008183	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
743722008184	active site
743722008185	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
743722008186	active site
743722008187	catalytic triad [active]
743722008188	oxyanion hole [active]
743722008189	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
743722008190	Permease; Region: Permease; pfam02405
743722008191	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
743722008192	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
743722008193	Walker A/P-loop; other site
743722008194	ATP binding site [chemical binding]; other site
743722008195	Q-loop/lid; other site
743722008196	ABC transporter signature motif; other site
743722008197	Walker B; other site
743722008198	D-loop; other site
743722008199	H-loop/switch region; other site
743722008200	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
743722008201	mce related protein; Region: MCE; pfam02470
743722008202	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
743722008203	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743722008204	active site
743722008205	YceG-like family; Region: YceG; pfam02618
743722008206	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
743722008207	dimerization interface [polypeptide binding]; other site
743722008208	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743722008209	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743722008210	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
743722008211	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
743722008212	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
743722008213	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722008214	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743722008215	active site
743722008216	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
743722008217	16S/18S rRNA binding site [nucleotide binding]; other site
743722008218	S13e-L30e interaction site [polypeptide binding]; other site
743722008219	25S rRNA binding site [nucleotide binding]; other site
743722008220	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
743722008221	active site
743722008222	catalytic triad [active]
743722008223	oxyanion hole [active]
743722008224	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722008225	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722008226	dimerization interface [polypeptide binding]; other site
743722008227	putative DNA binding site [nucleotide binding]; other site
743722008228	putative Zn2+ binding site [ion binding]; other site
743722008229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722008230	putative substrate translocation pore; other site
743722008231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722008232	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
743722008233	catalytic motif [active]
743722008234	Catalytic residue [active]
743722008235	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722008236	Coenzyme A binding pocket [chemical binding]; other site
743722008237	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
743722008238	catalytic motif [active]
743722008239	Catalytic residue [active]
743722008240	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722008241	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
743722008242	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
743722008243	RNase E interface [polypeptide binding]; other site
743722008244	trimer interface [polypeptide binding]; other site
743722008245	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
743722008246	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
743722008247	RNase E interface [polypeptide binding]; other site
743722008248	trimer interface [polypeptide binding]; other site
743722008249	active site
743722008250	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
743722008251	RNA binding site [nucleotide binding]; other site
743722008252	domain interface; other site
743722008253	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
743722008254	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
743722008255	substrate binding site [chemical binding]; other site
743722008256	hexamer interface [polypeptide binding]; other site
743722008257	metal binding site [ion binding]; metal-binding site
743722008258	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
743722008259	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722008260	catalytic residue [active]
743722008261	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
743722008262	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
743722008263	putative ligand binding site [chemical binding]; other site
743722008264	NAD binding site [chemical binding]; other site
743722008265	dimerization interface [polypeptide binding]; other site
743722008266	catalytic site [active]
743722008267	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
743722008268	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
743722008269	substrate binding pocket [chemical binding]; other site
743722008270	chain length determination region; other site
743722008271	substrate-Mg2+ binding site; other site
743722008272	catalytic residues [active]
743722008273	aspartate-rich region 1; other site
743722008274	active site lid residues [active]
743722008275	aspartate-rich region 2; other site
743722008276	ribonuclease R; Region: RNase_R; TIGR02063
743722008277	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
743722008278	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743722008279	RNB domain; Region: RNB; pfam00773
743722008280	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
743722008281	RNA binding site [nucleotide binding]; other site
743722008282	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
743722008283	metal binding site 2 [ion binding]; metal-binding site
743722008284	putative DNA binding helix; other site
743722008285	metal binding site 1 [ion binding]; metal-binding site
743722008286	dimer interface [polypeptide binding]; other site
743722008287	structural Zn2+ binding site [ion binding]; other site
743722008288	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
743722008289	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
743722008290	recombination protein RecR; Reviewed; Region: recR; PRK00076
743722008291	RecR protein; Region: RecR; pfam02132
743722008292	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
743722008293	putative active site [active]
743722008294	putative metal-binding site [ion binding]; other site
743722008295	tetramer interface [polypeptide binding]; other site
743722008296	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
743722008297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722008298	NAD(P) binding site [chemical binding]; other site
743722008299	active site
743722008300	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
743722008301	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
743722008302	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
743722008303	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
743722008304	active site
743722008305	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
743722008306	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
743722008307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722008308	catalytic residue [active]
743722008309	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
743722008310	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
743722008311	substrate binding site [chemical binding]; other site
743722008312	active site
743722008313	catalytic residues [active]
743722008314	heterodimer interface [polypeptide binding]; other site
743722008315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722008316	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722008317	putative substrate translocation pore; other site
743722008318	hypothetical protein; Provisional; Region: PRK08201
743722008319	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
743722008320	metal binding site [ion binding]; metal-binding site
743722008321	putative dimer interface [polypeptide binding]; other site
743722008322	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
743722008323	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
743722008324	motif 1; other site
743722008325	active site
743722008326	motif 2; other site
743722008327	motif 3; other site
743722008328	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
743722008329	DHHA1 domain; Region: DHHA1; pfam02272
743722008330	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
743722008331	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722008332	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722008333	catalytic residues [active]
743722008334	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722008335	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008336	active site
743722008337	phosphorylation site [posttranslational modification]
743722008338	intermolecular recognition site; other site
743722008339	dimerization interface [polypeptide binding]; other site
743722008340	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722008341	DNA binding site [nucleotide binding]
743722008342	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
743722008343	GAF domain; Region: GAF; pfam01590
743722008344	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722008345	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722008346	dimer interface [polypeptide binding]; other site
743722008347	phosphorylation site [posttranslational modification]
743722008348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722008349	ATP binding site [chemical binding]; other site
743722008350	Mg2+ binding site [ion binding]; other site
743722008351	G-X-G motif; other site
743722008352	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
743722008353	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
743722008354	active site
743722008355	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
743722008356	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
743722008357	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
743722008358	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
743722008359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722008360	non-specific DNA binding site [nucleotide binding]; other site
743722008361	salt bridge; other site
743722008362	sequence-specific DNA binding site [nucleotide binding]; other site
743722008363	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
743722008364	Catalytic site [active]
743722008365	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
743722008366	GIY-YIG motif/motif A; other site
743722008367	putative active site [active]
743722008368	putative metal binding site [ion binding]; other site
743722008369	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
743722008370	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722008371	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722008372	Transglycosylase; Region: Transgly; pfam00912
743722008373	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
743722008374	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
743722008375	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722008376	motif II; other site
743722008377	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
743722008378	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
743722008379	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
743722008380	Walker A/P-loop; other site
743722008381	ATP binding site [chemical binding]; other site
743722008382	Q-loop/lid; other site
743722008383	ABC transporter signature motif; other site
743722008384	Walker B; other site
743722008385	D-loop; other site
743722008386	H-loop/switch region; other site
743722008387	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
743722008388	chaperone protein DnaJ; Provisional; Region: PRK14289
743722008389	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
743722008390	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
743722008391	substrate binding site [polypeptide binding]; other site
743722008392	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
743722008393	Zn binding sites [ion binding]; other site
743722008394	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
743722008395	dimer interface [polypeptide binding]; other site
743722008396	heat shock protein GrpE; Provisional; Region: PRK14140
743722008397	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
743722008398	dimer interface [polypeptide binding]; other site
743722008399	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
743722008400	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
743722008401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722008402	Walker A/P-loop; other site
743722008403	ATP binding site [chemical binding]; other site
743722008404	Q-loop/lid; other site
743722008405	ABC transporter signature motif; other site
743722008406	Walker B; other site
743722008407	D-loop; other site
743722008408	H-loop/switch region; other site
743722008409	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
743722008410	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743722008411	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
743722008412	putative dimer interface [polypeptide binding]; other site
743722008413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722008414	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722008415	DinB family; Region: DinB; cl17821
743722008416	DinB superfamily; Region: DinB_2; pfam12867
743722008417	DoxX; Region: DoxX; pfam07681
743722008418	GTP-binding protein YchF; Reviewed; Region: PRK09601
743722008419	YchF GTPase; Region: YchF; cd01900
743722008420	G1 box; other site
743722008421	GTP/Mg2+ binding site [chemical binding]; other site
743722008422	Switch I region; other site
743722008423	G2 box; other site
743722008424	Switch II region; other site
743722008425	G3 box; other site
743722008426	G4 box; other site
743722008427	G5 box; other site
743722008428	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
743722008429	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
743722008430	putative DNA binding site [nucleotide binding]; other site
743722008431	putative Zn2+ binding site [ion binding]; other site
743722008432	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722008433	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
743722008434	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722008435	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008436	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722008437	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722008438	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722008439	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722008440	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
743722008441	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
743722008442	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
743722008443	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
743722008444	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
743722008445	RNA binding site [nucleotide binding]; other site
743722008446	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
743722008447	RNA binding site [nucleotide binding]; other site
743722008448	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
743722008449	RNA binding site [nucleotide binding]; other site
743722008450	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743722008451	RNA binding site [nucleotide binding]; other site
743722008452	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743722008453	RNA binding site [nucleotide binding]; other site
743722008454	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
743722008455	RNA binding site [nucleotide binding]; other site
743722008456	cytidylate kinase; Provisional; Region: cmk; PRK00023
743722008457	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
743722008458	CMP-binding site; other site
743722008459	The sites determining sugar specificity; other site
743722008460	hypothetical protein; Provisional; Region: PRK09256
743722008461	CcmE; Region: CcmE; cl00994
743722008462	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
743722008463	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
743722008464	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
743722008465	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722008466	motif II; other site
743722008467	Maf-like protein; Region: Maf; pfam02545
743722008468	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
743722008469	active site
743722008470	dimer interface [polypeptide binding]; other site
743722008471	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
743722008472	active site
743722008473	metal binding site [ion binding]; metal-binding site
743722008474	homotetramer interface [polypeptide binding]; other site
743722008475	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
743722008476	AMP binding site [chemical binding]; other site
743722008477	metal binding site [ion binding]; metal-binding site
743722008478	active site
743722008479	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743722008480	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
743722008481	DNA binding residues [nucleotide binding]
743722008482	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
743722008483	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
743722008484	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743722008485	Ligand Binding Site [chemical binding]; other site
743722008486	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
743722008487	isocitrate dehydrogenase; Validated; Region: PRK07362
743722008488	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
743722008489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008490	active site
743722008491	phosphorylation site [posttranslational modification]
743722008492	intermolecular recognition site; other site
743722008493	dimerization interface [polypeptide binding]; other site
743722008494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722008495	Walker A motif; other site
743722008496	ATP binding site [chemical binding]; other site
743722008497	Walker B motif; other site
743722008498	arginine finger; other site
743722008499	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
743722008500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722008501	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722008502	dimer interface [polypeptide binding]; other site
743722008503	phosphorylation site [posttranslational modification]
743722008504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722008505	ATP binding site [chemical binding]; other site
743722008506	Mg2+ binding site [ion binding]; other site
743722008507	G-X-G motif; other site
743722008508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008509	Response regulator receiver domain; Region: Response_reg; pfam00072
743722008510	active site
743722008511	phosphorylation site [posttranslational modification]
743722008512	intermolecular recognition site; other site
743722008513	dimerization interface [polypeptide binding]; other site
743722008514	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
743722008515	putative binding surface; other site
743722008516	active site
743722008517	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
743722008518	Clp amino terminal domain; Region: Clp_N; pfam02861
743722008519	Clp amino terminal domain; Region: Clp_N; pfam02861
743722008520	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722008521	Walker A motif; other site
743722008522	ATP binding site [chemical binding]; other site
743722008523	Walker B motif; other site
743722008524	arginine finger; other site
743722008525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722008526	Walker A motif; other site
743722008527	ATP binding site [chemical binding]; other site
743722008528	Walker B motif; other site
743722008529	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
743722008530	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
743722008531	hydrophobic ligand binding site; other site
743722008532	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722008533	active site
743722008534	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
743722008535	active site
743722008536	Ap6A binding site [chemical binding]; other site
743722008537	nudix motif; other site
743722008538	metal binding site [ion binding]; metal-binding site
743722008539	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
743722008540	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
743722008541	active site
743722008542	(T/H)XGH motif; other site
743722008543	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
743722008544	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722008545	S-adenosylmethionine binding site [chemical binding]; other site
743722008546	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
743722008547	AAA domain; Region: AAA_30; pfam13604
743722008548	Family description; Region: UvrD_C_2; pfam13538
743722008549	glutamate racemase; Provisional; Region: PRK00865
743722008550	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
743722008551	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
743722008552	active site
743722008553	FMN binding site [chemical binding]; other site
743722008554	substrate binding site [chemical binding]; other site
743722008555	3Fe-4S cluster binding site [ion binding]; other site
743722008556	Dehydroquinase class II; Region: DHquinase_II; pfam01220
743722008557	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
743722008558	trimer interface [polypeptide binding]; other site
743722008559	active site
743722008560	dimer interface [polypeptide binding]; other site
743722008561	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722008562	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
743722008563	Probable Catalytic site; other site
743722008564	metal-binding site
743722008565	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
743722008566	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
743722008567	putative acyl-acceptor binding pocket; other site
743722008568	WbqC-like protein family; Region: WbqC; pfam08889
743722008569	integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667
743722008570	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
743722008571	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
743722008572	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
743722008573	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
743722008574	putative oxidoreductase; Provisional; Region: PRK11579
743722008575	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722008576	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722008577	polyphosphate kinase; Provisional; Region: PRK05443
743722008578	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
743722008579	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
743722008580	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
743722008581	domain interface [polypeptide binding]; other site
743722008582	active site
743722008583	catalytic site [active]
743722008584	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
743722008585	domain interface [polypeptide binding]; other site
743722008586	active site
743722008587	catalytic site [active]
743722008588	exopolyphosphatase; Region: exo_poly_only; TIGR03706
743722008589	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
743722008590	aspartate kinase III; Validated; Region: PRK09084
743722008591	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
743722008592	nucleotide binding site [chemical binding]; other site
743722008593	substrate binding site [chemical binding]; other site
743722008594	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
743722008595	dimer interface [polypeptide binding]; other site
743722008596	allosteric regulatory binding pocket; other site
743722008597	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
743722008598	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
743722008599	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
743722008600	active site
743722008601	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743722008602	substrate binding site [chemical binding]; other site
743722008603	catalytic residues [active]
743722008604	dimer interface [polypeptide binding]; other site
743722008605	DNA topoisomerase I; Validated; Region: PRK06599
743722008606	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
743722008607	active site
743722008608	interdomain interaction site; other site
743722008609	putative metal-binding site [ion binding]; other site
743722008610	nucleotide binding site [chemical binding]; other site
743722008611	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
743722008612	domain I; other site
743722008613	DNA binding groove [nucleotide binding]
743722008614	phosphate binding site [ion binding]; other site
743722008615	domain II; other site
743722008616	domain III; other site
743722008617	nucleotide binding site [chemical binding]; other site
743722008618	catalytic site [active]
743722008619	domain IV; other site
743722008620	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743722008621	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
743722008622	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
743722008623	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
743722008624	Ligand Binding Site [chemical binding]; other site
743722008625	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743722008626	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722008627	NAD(P) binding site [chemical binding]; other site
743722008628	active site
743722008629	AIR carboxylase; Region: AIRC; pfam00731
743722008630	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
743722008631	ATP-grasp domain; Region: ATP-grasp; pfam02222
743722008632	NADH dehydrogenase subunit B; Validated; Region: PRK06411
743722008633	NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; Region: NuoA; COG0838
743722008634	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
743722008635	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722008636	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
743722008637	active site
743722008638	intersubunit interactions; other site
743722008639	catalytic residue [active]
743722008640	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
743722008641	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
743722008642	active site
743722008643	dimer interface [polypeptide binding]; other site
743722008644	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
743722008645	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
743722008646	active site
743722008647	FMN binding site [chemical binding]; other site
743722008648	substrate binding site [chemical binding]; other site
743722008649	3Fe-4S cluster binding site [ion binding]; other site
743722008650	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
743722008651	domain interface; other site
743722008652	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
743722008653	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743722008654	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
743722008655	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
743722008656	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
743722008657	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
743722008658	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722008659	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
743722008660	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743722008661	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743722008662	HEPN domain; Region: HEPN; cl00824
743722008663	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
743722008664	active site
743722008665	SAM binding site [chemical binding]; other site
743722008666	homodimer interface [polypeptide binding]; other site
743722008667	siroheme synthase, N-terminal domain; Region: cysG_Nterm; TIGR01470
743722008668	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
743722008669	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743722008670	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
743722008671	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
743722008672	Active Sites [active]
743722008673	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
743722008674	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
743722008675	Active Sites [active]
743722008676	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
743722008677	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
743722008678	CysD dimerization site [polypeptide binding]; other site
743722008679	G1 box; other site
743722008680	putative GEF interaction site [polypeptide binding]; other site
743722008681	GTP/Mg2+ binding site [chemical binding]; other site
743722008682	Switch I region; other site
743722008683	G2 box; other site
743722008684	G3 box; other site
743722008685	Switch II region; other site
743722008686	G4 box; other site
743722008687	G5 box; other site
743722008688	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
743722008689	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
743722008690	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722008691	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
743722008692	active site
743722008693	DNA polymerase IV; Validated; Region: PRK02406
743722008694	DNA binding site [nucleotide binding]
743722008695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008696	Response regulator receiver domain; Region: Response_reg; pfam00072
743722008697	active site
743722008698	phosphorylation site [posttranslational modification]
743722008699	intermolecular recognition site; other site
743722008700	dimerization interface [polypeptide binding]; other site
743722008701	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
743722008702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008703	Response regulator receiver domain; Region: Response_reg; pfam00072
743722008704	active site
743722008705	phosphorylation site [posttranslational modification]
743722008706	intermolecular recognition site; other site
743722008707	dimerization interface [polypeptide binding]; other site
743722008708	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722008709	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722008710	catalytic residues [active]
743722008711	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
743722008712	GTPase RsgA; Reviewed; Region: PRK01889
743722008713	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743722008714	RNA binding site [nucleotide binding]; other site
743722008715	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
743722008716	GTPase/Zn-binding domain interface [polypeptide binding]; other site
743722008717	GTP/Mg2+ binding site [chemical binding]; other site
743722008718	G4 box; other site
743722008719	G5 box; other site
743722008720	G1 box; other site
743722008721	Switch I region; other site
743722008722	G2 box; other site
743722008723	G3 box; other site
743722008724	Switch II region; other site
743722008725	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722008726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008727	active site
743722008728	phosphorylation site [posttranslational modification]
743722008729	intermolecular recognition site; other site
743722008730	dimerization interface [polypeptide binding]; other site
743722008731	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722008732	DNA binding residues [nucleotide binding]
743722008733	dimerization interface [polypeptide binding]; other site
743722008734	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722008735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722008736	active site
743722008737	phosphorylation site [posttranslational modification]
743722008738	intermolecular recognition site; other site
743722008739	dimerization interface [polypeptide binding]; other site
743722008740	LytTr DNA-binding domain; Region: LytTR; smart00850
743722008741	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008742	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722008743	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722008744	ligand binding site [chemical binding]; other site
743722008745	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722008746	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722008747	binding surface
743722008748	TPR motif; other site
743722008749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722008750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722008751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722008752	ATP binding site [chemical binding]; other site
743722008753	Mg2+ binding site [ion binding]; other site
743722008754	G-X-G motif; other site
743722008755	aspartate aminotransferase; Provisional; Region: PRK07568
743722008756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722008757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722008758	homodimer interface [polypeptide binding]; other site
743722008759	catalytic residue [active]
743722008760	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
743722008761	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
743722008762	tetramer interface [polypeptide binding]; other site
743722008763	TPP-binding site [chemical binding]; other site
743722008764	heterodimer interface [polypeptide binding]; other site
743722008765	phosphorylation loop region [posttranslational modification]
743722008766	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
743722008767	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
743722008768	PYR/PP interface [polypeptide binding]; other site
743722008769	dimer interface [polypeptide binding]; other site
743722008770	TPP binding site [chemical binding]; other site
743722008771	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722008772	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
743722008773	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
743722008774	Tetramer interface [polypeptide binding]; other site
743722008775	active site
743722008776	FMN-binding site [chemical binding]; other site
743722008777	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
743722008778	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
743722008779	hinge; other site
743722008780	active site
743722008781	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
743722008782	Chorismate mutase type II; Region: CM_2; smart00830
743722008783	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
743722008784	Prephenate dehydratase; Region: PDT; pfam00800
743722008785	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
743722008786	putative L-Phe binding site [chemical binding]; other site
743722008787	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
743722008788	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
743722008789	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
743722008790	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
743722008791	putative active site [active]
743722008792	putative NTP binding site [chemical binding]; other site
743722008793	putative nucleic acid binding site [nucleotide binding]; other site
743722008794	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
743722008795	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
743722008796	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722008797	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
743722008798	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
743722008799	Cupin domain; Region: Cupin_2; pfam07883
743722008800	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722008801	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722008802	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722008803	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722008804	ligand binding site [chemical binding]; other site
743722008805	flexible hinge region; other site
743722008806	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743722008807	putative switch regulator; other site
743722008808	non-specific DNA interactions [nucleotide binding]; other site
743722008809	DNA binding site [nucleotide binding]
743722008810	sequence specific DNA binding site [nucleotide binding]; other site
743722008811	putative cAMP binding site [chemical binding]; other site
743722008812	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
743722008813	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
743722008814	Cl- selectivity filter; other site
743722008815	Cl- binding residues [ion binding]; other site
743722008816	pore gating glutamate residue; other site
743722008817	dimer interface [polypeptide binding]; other site
743722008818	FOG: CBS domain [General function prediction only]; Region: COG0517
743722008819	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
743722008820	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
743722008821	N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119
743722008822	DNA binding site [nucleotide binding]
743722008823	catalytic residue [active]
743722008824	H2TH interface [polypeptide binding]; other site
743722008825	putative catalytic residues [active]
743722008826	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
743722008827	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
743722008828	nucleoside/Zn binding site; other site
743722008829	dimer interface [polypeptide binding]; other site
743722008830	catalytic motif [active]
743722008831	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
743722008832	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
743722008833	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
743722008834	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722008835	putative ADP-binding pocket [chemical binding]; other site
743722008836	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
743722008837	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
743722008838	putative dimer interface [polypeptide binding]; other site
743722008839	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
743722008840	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
743722008841	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722008842	Uncharacterized conserved protein [Function unknown]; Region: COG4544
743722008843	DNA Polymerase Y-family; Region: PolY_like; cd03468
743722008844	active site
743722008845	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
743722008846	DNA binding site [nucleotide binding]
743722008847	Dodecin; Region: Dodecin; pfam07311
743722008848	BCCT family transporter; Region: BCCT; pfam02028
743722008849	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722008850	Ligand Binding Site [chemical binding]; other site
743722008851	Protein of unknown function (DUF819); Region: DUF819; cl02317
743722008852	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
743722008853	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
743722008854	active site
743722008855	heat shock protein 90; Provisional; Region: PRK05218
743722008856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722008857	ATP binding site [chemical binding]; other site
743722008858	Mg2+ binding site [ion binding]; other site
743722008859	G-X-G motif; other site
743722008860	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
743722008861	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
743722008862	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
743722008863	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
743722008864	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
743722008865	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
743722008866	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722008867	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
743722008868	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722008869	DNA binding residues [nucleotide binding]
743722008870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
743722008871	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
743722008872	Na binding site [ion binding]; other site
743722008873	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
743722008874	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
743722008875	putative active site [active]
743722008876	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
743722008877	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722008878	active site
743722008879	metal binding site [ion binding]; metal-binding site
743722008880	PQQ-like domain; Region: PQQ_2; pfam13360
743722008881	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
743722008882	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
743722008883	Trp docking motif [polypeptide binding]; other site
743722008884	active site
743722008885	PQQ-like domain; Region: PQQ_2; pfam13360
743722008886	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
743722008887	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722008888	SusD family; Region: SusD; pfam07980
743722008889	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722008890	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008891	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722008892	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722008893	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722008894	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722008895	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722008896	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722008897	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008898	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722008899	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722008900	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722008901	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722008902	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722008903	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722008904	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722008905	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722008906	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722008907	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
743722008908	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722008909	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
743722008910	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722008911	Active site serine [active]
743722008912	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722008913	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722008914	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722008915	M28 Zn-Peptidases; Region: M28_like_2; cd05662
743722008916	Peptidase family M28; Region: Peptidase_M28; pfam04389
743722008917	metal binding site [ion binding]; metal-binding site
743722008918	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
743722008919	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
743722008920	Walker A/P-loop; other site
743722008921	ATP binding site [chemical binding]; other site
743722008922	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
743722008923	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
743722008924	ABC transporter signature motif; other site
743722008925	Walker B; other site
743722008926	D-loop; other site
743722008927	H-loop/switch region; other site
743722008928	C-N hydrolase family amidase; Provisional; Region: PRK10438
743722008929	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
743722008930	putative active site [active]
743722008931	catalytic triad [active]
743722008932	dimer interface [polypeptide binding]; other site
743722008933	multimer interface [polypeptide binding]; other site
743722008934	methionine aminotransferase; Validated; Region: PRK09082
743722008935	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722008936	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722008937	homodimer interface [polypeptide binding]; other site
743722008938	catalytic residue [active]
743722008939	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
743722008940	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
743722008941	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
743722008942	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
743722008943	TM-ABC transporter signature motif; other site
743722008944	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
743722008945	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722008946	Walker A/P-loop; other site
743722008947	ATP binding site [chemical binding]; other site
743722008948	Q-loop/lid; other site
743722008949	ABC transporter signature motif; other site
743722008950	Walker B; other site
743722008951	D-loop; other site
743722008952	H-loop/switch region; other site
743722008953	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743722008954	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722008955	Walker A/P-loop; other site
743722008956	ATP binding site [chemical binding]; other site
743722008957	Q-loop/lid; other site
743722008958	ABC transporter signature motif; other site
743722008959	Walker B; other site
743722008960	D-loop; other site
743722008961	H-loop/switch region; other site
743722008962	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722008963	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722008964	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722008965	DNA binding site [nucleotide binding]
743722008966	domain linker motif; other site
743722008967	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722008968	dimerization interface [polypeptide binding]; other site
743722008969	ligand binding site [chemical binding]; other site
743722008970	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
743722008971	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
743722008972	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722008973	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722008974	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
743722008975	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722008976	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722008977	ligand binding site [chemical binding]; other site
743722008978	flexible hinge region; other site
743722008979	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722008980	binding surface
743722008981	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722008982	TPR motif; other site
743722008983	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
743722008984	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722008985	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722008986	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722008987	ligand binding site [chemical binding]; other site
743722008988	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
743722008989	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722008990	FeS/SAM binding site; other site
743722008991	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722008992	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722008993	Phosphotransferase enzyme family; Region: APH; pfam01636
743722008994	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
743722008995	substrate binding site [chemical binding]; other site
743722008996	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
743722008997	putative ligand binding site [chemical binding]; other site
743722008998	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
743722008999	RNA/DNA hybrid binding site [nucleotide binding]; other site
743722009000	active site
743722009001	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722009002	MarR family; Region: MarR; pfam01047
743722009003	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
743722009004	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722009005	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722009006	DNA binding residues [nucleotide binding]
743722009007	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
743722009008	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
743722009009	formimidoylglutamase; Provisional; Region: PRK13775
743722009010	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
743722009011	putative active site [active]
743722009012	putative metal binding site [ion binding]; other site
743722009013	imidazolonepropionase; Validated; Region: PRK09356
743722009014	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722009015	active site
743722009016	urocanate hydratase; Provisional; Region: PRK05414
743722009017	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
743722009018	active sites [active]
743722009019	tetramer interface [polypeptide binding]; other site
743722009020	MarR family; Region: MarR_2; pfam12802
743722009021	Transcriptional regulators [Transcription]; Region: MarR; COG1846
743722009022	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
743722009023	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
743722009024	asparagine synthetase B; Provisional; Region: asnB; PRK09431
743722009025	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
743722009026	active site
743722009027	dimer interface [polypeptide binding]; other site
743722009028	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
743722009029	Ligand Binding Site [chemical binding]; other site
743722009030	Molecular Tunnel; other site
743722009031	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
743722009032	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
743722009033	acyl-activating enzyme (AAE) consensus motif; other site
743722009034	putative AMP binding site [chemical binding]; other site
743722009035	putative active site [active]
743722009036	putative CoA binding site [chemical binding]; other site
743722009037	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
743722009038	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722009039	nucleophilic elbow; other site
743722009040	catalytic triad; other site
743722009041	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743722009042	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722009043	DNA-binding site [nucleotide binding]; DNA binding site
743722009044	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722009045	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722009046	homodimer interface [polypeptide binding]; other site
743722009047	catalytic residue [active]
743722009048	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
743722009049	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
743722009050	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722009051	catalytic residue [active]
743722009052	AAA domain; Region: AAA_26; pfam13500
743722009053	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
743722009054	biotin synthase; Region: bioB; TIGR00433
743722009055	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722009056	FeS/SAM binding site; other site
743722009057	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
743722009058	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743722009059	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
743722009060	inhibitor-cofactor binding pocket; inhibition site
743722009061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722009062	catalytic residue [active]
743722009063	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722009064	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722009065	EcsC protein family; Region: EcsC; pfam12787
743722009066	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
743722009067	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
743722009068	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
743722009069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722009070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722009071	FemAB family; Region: FemAB; pfam02388
743722009072	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
743722009073	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
743722009074	S1 domain; Region: S1_2; pfam13509
743722009075	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
743722009076	Rdx family; Region: Rdx; cl01407
743722009077	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
743722009078	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743722009079	active site
743722009080	oxyanion hole [active]
743722009081	catalytic triad [active]
743722009082	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
743722009083	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743722009084	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743722009085	active site
743722009086	oxyanion hole [active]
743722009087	catalytic triad [active]
743722009088	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
743722009089	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
743722009090	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722009091	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722009092	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
743722009093	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
743722009094	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
743722009095	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
743722009096	putative dimer interface [polypeptide binding]; other site
743722009097	putative anticodon binding site; other site
743722009098	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
743722009099	homodimer interface [polypeptide binding]; other site
743722009100	motif 1; other site
743722009101	motif 2; other site
743722009102	active site
743722009103	motif 3; other site
743722009104	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
743722009105	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
743722009106	CoA-ligase; Region: Ligase_CoA; pfam00549
743722009107	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722009108	Zn2+ binding site [ion binding]; other site
743722009109	Mg2+ binding site [ion binding]; other site
743722009110	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
743722009111	NADH dehydrogenase subunit D; Validated; Region: PRK06075
743722009112	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
743722009113	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
743722009114	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
743722009115	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
743722009116	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
743722009117	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
743722009118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009119	active site
743722009120	phosphorylation site [posttranslational modification]
743722009121	intermolecular recognition site; other site
743722009122	dimerization interface [polypeptide binding]; other site
743722009123	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722009124	Walker A motif; other site
743722009125	ATP binding site [chemical binding]; other site
743722009126	Walker B motif; other site
743722009127	arginine finger; other site
743722009128	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
743722009129	Cytochrome c; Region: Cytochrom_C; pfam00034
743722009130	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
743722009131	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
743722009132	Cu(I) binding site [ion binding]; other site
743722009133	Divergent AAA domain; Region: AAA_4; pfam04326
743722009134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722009135	putative substrate translocation pore; other site
743722009136	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722009137	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722009138	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
743722009139	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722009140	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722009141	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743722009142	dimerization interface [polypeptide binding]; other site
743722009143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722009144	dimer interface [polypeptide binding]; other site
743722009145	phosphorylation site [posttranslational modification]
743722009146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722009147	ATP binding site [chemical binding]; other site
743722009148	Mg2+ binding site [ion binding]; other site
743722009149	G-X-G motif; other site
743722009150	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722009151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009152	active site
743722009153	phosphorylation site [posttranslational modification]
743722009154	intermolecular recognition site; other site
743722009155	dimerization interface [polypeptide binding]; other site
743722009156	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722009157	DNA binding site [nucleotide binding]
743722009158	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
743722009159	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
743722009160	DNA gyrase subunit A; Validated; Region: PRK05560
743722009161	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
743722009162	CAP-like domain; other site
743722009163	active site
743722009164	primary dimer interface [polypeptide binding]; other site
743722009165	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743722009166	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743722009167	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743722009168	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
743722009169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722009170	binding surface
743722009171	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722009172	TPR motif; other site
743722009173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722009174	TPR motif; other site
743722009175	binding surface
743722009176	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722009177	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722009178	binding surface
743722009179	TPR motif; other site
743722009180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722009181	binding surface
743722009182	TPR motif; other site
743722009183	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
743722009184	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
743722009185	putative active site [active]
743722009186	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
743722009187	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
743722009188	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722009189	ATP binding site [chemical binding]; other site
743722009190	putative Mg++ binding site [ion binding]; other site
743722009191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722009192	nucleotide binding region [chemical binding]; other site
743722009193	ATP-binding site [chemical binding]; other site
743722009194	RQC domain; Region: RQC; pfam09382
743722009195	HRDC domain; Region: HRDC; pfam00570
743722009196	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
743722009197	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
743722009198	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
743722009199	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
743722009200	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
743722009201	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
743722009202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
743722009203	Uncharacterized conserved protein [Function unknown]; Region: COG2308
743722009204	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
743722009205	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722009206	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
743722009207	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722009208	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743722009209	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743722009210	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722009211	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722009212	active site
743722009213	catalytic tetrad [active]
743722009214	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
743722009215	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743722009216	catalytic core [active]
743722009217	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
743722009218	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722009219	FeS/SAM binding site; other site
743722009220	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722009221	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743722009222	Coenzyme A binding pocket [chemical binding]; other site
743722009223	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
743722009224	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743722009225	homodimer interface [polypeptide binding]; other site
743722009226	substrate-cofactor binding pocket; other site
743722009227	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722009228	catalytic residue [active]
743722009229	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
743722009230	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
743722009231	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
743722009232	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
743722009233	HI0933-like protein; Region: HI0933_like; pfam03486
743722009234	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722009235	putative oxidoreductase; Provisional; Region: PRK11579
743722009236	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722009237	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722009238	Uncharacterized conserved protein [Function unknown]; Region: COG3391
743722009239	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
743722009240	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
743722009241	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
743722009242	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
743722009243	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
743722009244	active site
743722009245	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
743722009246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722009247	S-adenosylmethionine binding site [chemical binding]; other site
743722009248	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
743722009249	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
743722009250	catalytic motif [active]
743722009251	Zn binding site [ion binding]; other site
743722009252	RibD C-terminal domain; Region: RibD_C; cl17279
743722009253	Uncharacterized conserved protein [Function unknown]; Region: COG1739
743722009254	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
743722009255	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
743722009256	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
743722009257	Predicted transcriptional regulator [Transcription]; Region: COG2378
743722009258	HTH domain; Region: HTH_11; pfam08279
743722009259	WYL domain; Region: WYL; pfam13280
743722009260	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722009261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
743722009262	Uncharacterized conserved protein [Function unknown]; Region: COG2353
743722009263	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722009264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722009265	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722009266	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722009267	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722009268	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722009269	N-terminal plug; other site
743722009270	ligand-binding site [chemical binding]; other site
743722009271	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722009272	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
743722009273	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722009274	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722009275	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722009276	FecR protein; Region: FecR; pfam04773
743722009277	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722009278	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722009279	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722009280	DNA binding residues [nucleotide binding]
743722009281	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722009282	Ligand Binding Site [chemical binding]; other site
743722009283	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
743722009284	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
743722009285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722009286	S-adenosylmethionine binding site [chemical binding]; other site
743722009287	FOG: WD40 repeat [General function prediction only]; Region: COG2319
743722009288	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
743722009289	structural tetrad; other site
743722009290	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722009291	Histidine kinase; Region: His_kinase; pfam06580
743722009292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009293	Response regulator receiver domain; Region: Response_reg; pfam00072
743722009294	active site
743722009295	phosphorylation site [posttranslational modification]
743722009296	intermolecular recognition site; other site
743722009297	dimerization interface [polypeptide binding]; other site
743722009298	LytTr DNA-binding domain; Region: LytTR; smart00850
743722009299	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
743722009300	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722009301	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
743722009302	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722009303	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722009304	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722009305	FtsX-like permease family; Region: FtsX; pfam02687
743722009306	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743722009307	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722009308	Walker A/P-loop; other site
743722009309	ATP binding site [chemical binding]; other site
743722009310	Q-loop/lid; other site
743722009311	ABC transporter signature motif; other site
743722009312	Walker B; other site
743722009313	D-loop; other site
743722009314	H-loop/switch region; other site
743722009315	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722009316	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722009317	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722009318	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722009319	Histidine kinase; Region: His_kinase; pfam06580
743722009320	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722009321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009322	active site
743722009323	phosphorylation site [posttranslational modification]
743722009324	intermolecular recognition site; other site
743722009325	dimerization interface [polypeptide binding]; other site
743722009326	LytTr DNA-binding domain; Region: LytTR; smart00850
743722009327	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722009328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009329	active site
743722009330	phosphorylation site [posttranslational modification]
743722009331	intermolecular recognition site; other site
743722009332	dimerization interface [polypeptide binding]; other site
743722009333	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722009334	DNA binding site [nucleotide binding]
743722009335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722009336	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722009337	dimer interface [polypeptide binding]; other site
743722009338	phosphorylation site [posttranslational modification]
743722009339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722009340	ATP binding site [chemical binding]; other site
743722009341	Mg2+ binding site [ion binding]; other site
743722009342	G-X-G motif; other site
743722009343	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
743722009344	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
743722009345	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
743722009346	Galactose oxidase, central domain; Region: Kelch_3; cl02701
743722009347	Galactose oxidase, central domain; Region: Kelch_3; cl02701
743722009348	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722009349	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722009350	active site
743722009351	catalytic tetrad [active]
743722009352	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
743722009353	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
743722009354	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
743722009355	putative DNA binding site [nucleotide binding]; other site
743722009356	putative homodimer interface [polypeptide binding]; other site
743722009357	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
743722009358	glutamate dehydrogenase; Provisional; Region: PRK09414
743722009359	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
743722009360	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
743722009361	NAD(P) binding site [chemical binding]; other site
743722009362	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
743722009363	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
743722009364	active site
743722009365	DNA binding site [nucleotide binding]
743722009366	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
743722009367	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
743722009368	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
743722009369	active site
743722009370	PHP Thumb interface [polypeptide binding]; other site
743722009371	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743722009372	active site
743722009373	substrate binding site [chemical binding]; other site
743722009374	catalytic site [active]
743722009375	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
743722009376	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
743722009377	GIY-YIG motif/motif A; other site
743722009378	active site
743722009379	catalytic site [active]
743722009380	putative DNA binding site [nucleotide binding]; other site
743722009381	metal binding site [ion binding]; metal-binding site
743722009382	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722009383	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722009384	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722009385	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722009386	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
743722009387	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722009388	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743722009389	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
743722009390	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
743722009391	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722009392	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722009393	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
743722009394	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722009395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722009396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
743722009397	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
743722009398	active site
743722009399	nucleophile elbow; other site
743722009400	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
743722009401	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
743722009402	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
743722009403	pantothenate kinase; Provisional; Region: PRK05439
743722009404	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
743722009405	ATP-binding site [chemical binding]; other site
743722009406	CoA-binding site [chemical binding]; other site
743722009407	Mg2+-binding site [ion binding]; other site
743722009408	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
743722009409	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743722009410	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
743722009411	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722009412	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743722009413	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722009414	metal-binding site [ion binding]
743722009415	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722009416	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722009417	Phosphotransferase enzyme family; Region: APH; pfam01636
743722009418	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
743722009419	active site
743722009420	substrate binding site [chemical binding]; other site
743722009421	ATP binding site [chemical binding]; other site
743722009422	GTP-binding protein LepA; Provisional; Region: PRK05433
743722009423	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
743722009424	G1 box; other site
743722009425	putative GEF interaction site [polypeptide binding]; other site
743722009426	GTP/Mg2+ binding site [chemical binding]; other site
743722009427	Switch I region; other site
743722009428	G2 box; other site
743722009429	G3 box; other site
743722009430	Switch II region; other site
743722009431	G4 box; other site
743722009432	G5 box; other site
743722009433	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
743722009434	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
743722009435	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
743722009436	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
743722009437	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
743722009438	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
743722009439	homodimer interface [polypeptide binding]; other site
743722009440	NADP binding site [chemical binding]; other site
743722009441	substrate binding site [chemical binding]; other site
743722009442	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743722009443	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
743722009444	ApbE family; Region: ApbE; pfam02424
743722009445	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722009446	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722009447	Uncharacterized conserved protein [Function unknown]; Region: COG1262
743722009448	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722009449	Protein of unknown function, DUF488; Region: DUF488; cl01246
743722009450	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
743722009451	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
743722009452	active site
743722009453	DNA binding site [nucleotide binding]
743722009454	Int/Topo IB signature motif; other site
743722009455	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
743722009456	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
743722009457	CHAP domain; Region: CHAP; cl17642
743722009458	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
743722009459	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
743722009460	active site
743722009461	hypothetical protein; Provisional; Region: PRK11281
743722009462	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
743722009463	oligomer interface [polypeptide binding]; other site
743722009464	active site residues [active]
743722009465	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
743722009466	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
743722009467	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
743722009468	cofactor binding site; other site
743722009469	DNA binding site [nucleotide binding]
743722009470	substrate interaction site [chemical binding]; other site
743722009471	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
743722009472	VirE N-terminal domain; Region: VirE_N; pfam08800
743722009473	HD domain; Region: HD_3; cl17350
743722009474	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722009475	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722009476	DNA binding residues [nucleotide binding]
743722009477	dimerization interface [polypeptide binding]; other site
743722009478	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
743722009479	Alginate lyase; Region: Alginate_lyase; pfam05426
743722009480	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
743722009481	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
743722009482	active site
743722009483	HIGH motif; other site
743722009484	dimer interface [polypeptide binding]; other site
743722009485	KMSKS motif; other site
743722009486	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
743722009487	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
743722009488	Substrate-binding site [chemical binding]; other site
743722009489	Substrate specificity [chemical binding]; other site
743722009490	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
743722009491	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
743722009492	Ligand binding site; other site
743722009493	oligomer interface; other site
743722009494	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
743722009495	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
743722009496	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
743722009497	Walker A/P-loop; other site
743722009498	ATP binding site [chemical binding]; other site
743722009499	Q-loop/lid; other site
743722009500	ABC transporter signature motif; other site
743722009501	Walker B; other site
743722009502	D-loop; other site
743722009503	H-loop/switch region; other site
743722009504	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
743722009505	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
743722009506	putative acyl-acceptor binding pocket; other site
743722009507	helicase 45; Provisional; Region: PTZ00424
743722009508	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743722009509	ATP binding site [chemical binding]; other site
743722009510	Mg++ binding site [ion binding]; other site
743722009511	motif III; other site
743722009512	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722009513	nucleotide binding region [chemical binding]; other site
743722009514	ATP-binding site [chemical binding]; other site
743722009515	CTP synthetase; Validated; Region: pyrG; PRK05380
743722009516	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
743722009517	Catalytic site [active]
743722009518	active site
743722009519	UTP binding site [chemical binding]; other site
743722009520	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
743722009521	active site
743722009522	putative oxyanion hole; other site
743722009523	catalytic triad [active]
743722009524	membrane protein insertase; Provisional; Region: PRK01318
743722009525	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
743722009526	PAS domain S-box; Region: sensory_box; TIGR00229
743722009527	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722009528	putative active site [active]
743722009529	heme pocket [chemical binding]; other site
743722009530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722009531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722009532	dimer interface [polypeptide binding]; other site
743722009533	phosphorylation site [posttranslational modification]
743722009534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722009535	ATP binding site [chemical binding]; other site
743722009536	G-X-G motif; other site
743722009537	Response regulator receiver domain; Region: Response_reg; pfam00072
743722009538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009539	active site
743722009540	phosphorylation site [posttranslational modification]
743722009541	intermolecular recognition site; other site
743722009542	dimerization interface [polypeptide binding]; other site
743722009543	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722009544	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722009545	ligand binding site [chemical binding]; other site
743722009546	flexible hinge region; other site
743722009547	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743722009548	putative switch regulator; other site
743722009549	non-specific DNA interactions [nucleotide binding]; other site
743722009550	DNA binding site [nucleotide binding]
743722009551	sequence specific DNA binding site [nucleotide binding]; other site
743722009552	putative cAMP binding site [chemical binding]; other site
743722009553	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
743722009554	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
743722009555	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722009556	FeS/SAM binding site; other site
743722009557	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
743722009558	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743722009559	Heavy-metal-associated domain; Region: HMA; pfam00403
743722009560	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722009561	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722009562	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
743722009563	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
743722009564	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
743722009565	Low-spin heme binding site [chemical binding]; other site
743722009566	Putative water exit pathway; other site
743722009567	Binuclear center (active site) [active]
743722009568	Putative proton exit pathway; other site
743722009569	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
743722009570	Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506
743722009571	Cytochrome c; Region: Cytochrom_C; pfam00034
743722009572	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
743722009573	4Fe-4S binding domain; Region: Fer4_5; pfam12801
743722009574	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
743722009575	FixH; Region: FixH; pfam05751
743722009576	Family description; Region: DsbD_2; pfam13386
743722009577	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
743722009578	iron-sulfur cluster [ion binding]; other site
743722009579	[2Fe-2S] cluster binding site [ion binding]; other site
743722009580	TfoX N-terminal domain; Region: TfoX_N; pfam04993
743722009581	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
743722009582	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
743722009583	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
743722009584	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
743722009585	quinone interaction residues [chemical binding]; other site
743722009586	active site
743722009587	catalytic residues [active]
743722009588	FMN binding site [chemical binding]; other site
743722009589	substrate binding site [chemical binding]; other site
743722009590	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
743722009591	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722009592	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722009593	ABC transporter; Region: ABC_tran_2; pfam12848
743722009594	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
743722009595	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
743722009596	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
743722009597	EVE domain; Region: EVE; pfam01878
743722009598	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
743722009599	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722009600	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
743722009601	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
743722009602	catalytic residues [active]
743722009603	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
743722009604	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
743722009605	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
743722009606	active site
743722009607	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
743722009608	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
743722009609	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
743722009610	active site
743722009611	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
743722009612	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
743722009613	homodimer interface [polypeptide binding]; other site
743722009614	metal binding site [ion binding]; metal-binding site
743722009615	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
743722009616	homodimer interface [polypeptide binding]; other site
743722009617	active site
743722009618	putative chemical substrate binding site [chemical binding]; other site
743722009619	metal binding site [ion binding]; metal-binding site
743722009620	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
743722009621	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722009622	FtsX-like permease family; Region: FtsX; pfam02687
743722009623	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
743722009624	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
743722009625	putative active site [active]
743722009626	substrate binding site [chemical binding]; other site
743722009627	putative cosubstrate binding site; other site
743722009628	catalytic site [active]
743722009629	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
743722009630	substrate binding site [chemical binding]; other site
743722009631	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
743722009632	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
743722009633	homodimer interface [polypeptide binding]; other site
743722009634	substrate-cofactor binding pocket; other site
743722009635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722009636	catalytic residue [active]
743722009637	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
743722009638	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
743722009639	RNA binding surface [nucleotide binding]; other site
743722009640	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
743722009641	active site
743722009642	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722009643	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009644	active site
743722009645	phosphorylation site [posttranslational modification]
743722009646	intermolecular recognition site; other site
743722009647	dimerization interface [polypeptide binding]; other site
743722009648	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722009649	DNA binding residues [nucleotide binding]
743722009650	dimerization interface [polypeptide binding]; other site
743722009651	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
743722009652	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
743722009653	NAD(P) binding site [chemical binding]; other site
743722009654	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
743722009655	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
743722009656	catalytic residues [active]
743722009657	catalytic nucleophile [active]
743722009658	Recombinase; Region: Recombinase; pfam07508
743722009659	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
743722009660	Antirestriction protein (ArdA); Region: ArdA; pfam07275
743722009661	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722009662	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722009663	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722009664	TIR domain; Region: TIR_2; pfam13676
743722009665	Caspase domain; Region: Peptidase_C14; pfam00656
743722009666	Response regulator receiver domain; Region: Response_reg; pfam00072
743722009667	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722009668	active site
743722009669	dimerization interface [polypeptide binding]; other site
743722009670	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
743722009671	Conjugative transposon protein TraO; Region: TraO; pfam10626
743722009672	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
743722009673	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
743722009674	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
743722009675	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
743722009676	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
743722009677	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
743722009678	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
743722009679	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
743722009680	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
743722009681	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
743722009682	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722009683	Walker A/P-loop; other site
743722009684	ATP binding site [chemical binding]; other site
743722009685	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
743722009686	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
743722009687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722009688	non-specific DNA binding site [nucleotide binding]; other site
743722009689	salt bridge; other site
743722009690	sequence-specific DNA binding site [nucleotide binding]; other site
743722009691	AAA domain; Region: AAA_23; pfam13476
743722009692	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722009693	Walker A/P-loop; other site
743722009694	ATP binding site [chemical binding]; other site
743722009695	Q-loop/lid; other site
743722009696	AAA domain; Region: AAA_21; pfam13304
743722009697	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722009698	ABC transporter signature motif; other site
743722009699	Walker B; other site
743722009700	D-loop; other site
743722009701	H-loop/switch region; other site
743722009702	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
743722009703	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
743722009704	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
743722009705	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
743722009706	P-loop; other site
743722009707	Magnesium ion binding site [ion binding]; other site
743722009708	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
743722009709	YWFCY protein; Region: YWFCY; pfam14293
743722009710	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
743722009711	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
743722009712	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722009713	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722009714	ligand binding site [chemical binding]; other site
743722009715	flexible hinge region; other site
743722009716	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
743722009717	non-specific DNA interactions [nucleotide binding]; other site
743722009718	DNA binding site [nucleotide binding]
743722009719	sequence specific DNA binding site [nucleotide binding]; other site
743722009720	putative cAMP binding site [chemical binding]; other site
743722009721	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743722009722	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
743722009723	Rhodanese-like domain; Region: Rhodanese; pfam00581
743722009724	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722009725	active site residue [active]
743722009726	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722009727	active site residue [active]
743722009728	Methyltransferase domain; Region: Methyltransf_11; pfam08241
743722009729	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722009730	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722009731	catalytic residues [active]
743722009732	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
743722009733	Predicted transporter component [General function prediction only]; Region: COG2391
743722009734	Sulphur transport; Region: Sulf_transp; pfam04143
743722009735	Predicted transporter component [General function prediction only]; Region: COG2391
743722009736	Sulphur transport; Region: Sulf_transp; pfam04143
743722009737	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
743722009738	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
743722009739	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722009740	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722009741	active site residue [active]
743722009742	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722009743	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722009744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722009745	Isochorismatase family; Region: Isochorismatase; pfam00857
743722009746	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
743722009747	catalytic triad [active]
743722009748	conserved cis-peptide bond; other site
743722009749	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722009750	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722009751	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722009752	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722009753	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722009754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722009755	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722009756	catalytic residues [active]
743722009757	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
743722009758	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
743722009759	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
743722009760	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
743722009761	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722009762	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722009763	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722009764	catalytic residues [active]
743722009765	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722009766	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722009767	catalytic residues [active]
743722009768	RteC protein; Region: RteC; pfam09357
743722009769	DNA topoisomerase III; Provisional; Region: PRK07726
743722009770	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
743722009771	active site
743722009772	putative interdomain interaction site [polypeptide binding]; other site
743722009773	putative metal-binding site [ion binding]; other site
743722009774	putative nucleotide binding site [chemical binding]; other site
743722009775	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
743722009776	domain I; other site
743722009777	DNA binding groove [nucleotide binding]
743722009778	phosphate binding site [ion binding]; other site
743722009779	domain II; other site
743722009780	domain III; other site
743722009781	nucleotide binding site [chemical binding]; other site
743722009782	catalytic site [active]
743722009783	domain IV; other site
743722009784	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
743722009785	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
743722009786	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
743722009787	RteC protein; Region: RteC; pfam09357
743722009788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722009789	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
743722009790	Walker A motif; other site
743722009791	ATP binding site [chemical binding]; other site
743722009792	Walker B motif; other site
743722009793	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
743722009794	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
743722009795	active site
743722009796	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722009797	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
743722009798	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
743722009799	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722009800	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
743722009801	protein binding site [polypeptide binding]; other site
743722009802	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
743722009803	Domain interface; other site
743722009804	Peptide binding site; other site
743722009805	Active site tetrad [active]
743722009806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722009807	S-adenosylmethionine binding site [chemical binding]; other site
743722009808	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
743722009809	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
743722009810	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722009811	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722009812	adenylosuccinate lyase; Provisional; Region: PRK09285
743722009813	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
743722009814	tetramer interface [polypeptide binding]; other site
743722009815	active site
743722009816	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
743722009817	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
743722009818	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
743722009819	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
743722009820	active site
743722009821	dimerization interface [polypeptide binding]; other site
743722009822	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
743722009823	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
743722009824	dimer interface [polypeptide binding]; other site
743722009825	Citrate synthase; Region: Citrate_synt; pfam00285
743722009826	active site
743722009827	citrylCoA binding site [chemical binding]; other site
743722009828	NADH binding [chemical binding]; other site
743722009829	cationic pore residues; other site
743722009830	oxalacetate/citrate binding site [chemical binding]; other site
743722009831	coenzyme A binding site [chemical binding]; other site
743722009832	catalytic triad [active]
743722009833	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
743722009834	Penicillinase repressor; Region: Pencillinase_R; pfam03965
743722009835	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
743722009836	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722009837	GLPGLI family protein; Region: GLPGLI; TIGR01200
743722009838	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722009839	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
743722009840	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
743722009841	substrate binding site [chemical binding]; other site
743722009842	oxyanion hole (OAH) forming residues; other site
743722009843	trimer interface [polypeptide binding]; other site
743722009844	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722009845	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722009846	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722009847	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722009848	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722009849	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722009850	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
743722009851	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
743722009852	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
743722009853	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
743722009854	active site
743722009855	metal binding site [ion binding]; metal-binding site
743722009856	nudix motif; other site
743722009857	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
743722009858	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722009859	S-adenosylmethionine binding site [chemical binding]; other site
743722009860	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
743722009861	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722009862	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722009863	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722009864	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
743722009865	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722009866	nucleoside transporter; Region: 2A0110; TIGR00889
743722009867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722009868	putative substrate translocation pore; other site
743722009869	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
743722009870	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743722009871	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
743722009872	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
743722009873	active site
743722009874	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
743722009875	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
743722009876	G1 box; other site
743722009877	putative GEF interaction site [polypeptide binding]; other site
743722009878	GTP/Mg2+ binding site [chemical binding]; other site
743722009879	Switch I region; other site
743722009880	G2 box; other site
743722009881	G3 box; other site
743722009882	Switch II region; other site
743722009883	G4 box; other site
743722009884	G5 box; other site
743722009885	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
743722009886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
743722009887	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
743722009888	Uncharacterized conserved protein [Function unknown]; Region: COG3391
743722009889	TonB-dependent vitamin B12 receptor; Region: TonB-B12; TIGR01779
743722009890	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722009891	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
743722009892	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
743722009893	putative catalytic cysteine [active]
743722009894	gamma-glutamyl kinase; Provisional; Region: PRK05429
743722009895	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
743722009896	nucleotide binding site [chemical binding]; other site
743722009897	homotetrameric interface [polypeptide binding]; other site
743722009898	putative phosphate binding site [ion binding]; other site
743722009899	putative allosteric binding site; other site
743722009900	PUA domain; Region: PUA; pfam01472
743722009901	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
743722009902	Ligand Binding Site [chemical binding]; other site
743722009903	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722009904	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722009905	Peptidase family M23; Region: Peptidase_M23; pfam01551
743722009906	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722009907	active site
743722009908	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
743722009909	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
743722009910	putative ATP binding site [chemical binding]; other site
743722009911	putative substrate interface [chemical binding]; other site
743722009912	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
743722009913	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
743722009914	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
743722009915	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722009916	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
743722009917	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722009918	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722009919	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722009920	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722009921	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722009922	EamA-like transporter family; Region: EamA; pfam00892
743722009923	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
743722009924	EamA-like transporter family; Region: EamA; pfam00892
743722009925	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
743722009926	Domain of unknown function (DUF1508); Region: DUF1508; pfam07411
743722009927	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
743722009928	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
743722009929	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
743722009930	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743722009931	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743722009932	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
743722009933	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
743722009934	active site
743722009935	putative interdomain interaction site [polypeptide binding]; other site
743722009936	putative metal-binding site [ion binding]; other site
743722009937	putative nucleotide binding site [chemical binding]; other site
743722009938	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
743722009939	domain I; other site
743722009940	DNA binding groove [nucleotide binding]
743722009941	phosphate binding site [ion binding]; other site
743722009942	domain II; other site
743722009943	domain III; other site
743722009944	nucleotide binding site [chemical binding]; other site
743722009945	catalytic site [active]
743722009946	domain IV; other site
743722009947	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
743722009948	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
743722009949	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
743722009950	tetrameric interface [polypeptide binding]; other site
743722009951	activator binding site; other site
743722009952	NADP binding site [chemical binding]; other site
743722009953	substrate binding site [chemical binding]; other site
743722009954	catalytic residues [active]
743722009955	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722009956	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722009957	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722009958	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
743722009959	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
743722009960	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
743722009961	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
743722009962	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
743722009963	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722009964	catalytic residue [active]
743722009965	L-lysine aminotransferase; Provisional; Region: PRK08297
743722009966	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743722009967	inhibitor-cofactor binding pocket; inhibition site
743722009968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722009969	catalytic residue [active]
743722009970	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
743722009971	Domain of unknown function DUF21; Region: DUF21; pfam01595
743722009972	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
743722009973	Transporter associated domain; Region: CorC_HlyC; smart01091
743722009974	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
743722009975	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
743722009976	conserved cys residue [active]
743722009977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722009978	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722009979	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722009980	Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369
743722009981	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
743722009982	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
743722009983	nudix motif; other site
743722009984	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
743722009985	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
743722009986	active site
743722009987	DNA binding site [nucleotide binding]
743722009988	Int/Topo IB signature motif; other site
743722009989	catalytic residues [active]
743722009990	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743722009991	phosphate binding site [ion binding]; other site
743722009992	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
743722009993	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
743722009994	phosphate binding site [ion binding]; other site
743722009995	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
743722009996	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
743722009997	active site
743722009998	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
743722009999	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
743722010000	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
743722010001	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
743722010002	putative NADP binding site [chemical binding]; other site
743722010003	active site
743722010004	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
743722010005	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
743722010006	active site
743722010007	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
743722010008	Acyl transferase domain; Region: Acyl_transf_1; cl08282
743722010009	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
743722010010	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
743722010011	Phosphopantetheine attachment site; Region: PP-binding; cl09936
743722010012	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
743722010013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722010014	S-adenosylmethionine binding site [chemical binding]; other site
743722010015	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722010016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010017	putative substrate translocation pore; other site
743722010018	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010019	sphingolipid delta-4 desaturase; Region: PLN02579
743722010020	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
743722010021	putative di-iron ligands [ion binding]; other site
743722010022	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
743722010023	heme binding pocket [chemical binding]; other site
743722010024	heme ligand [chemical binding]; other site
743722010025	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722010026	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722010027	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722010028	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722010029	Active site serine [active]
743722010030	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
743722010031	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105
743722010032	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010033	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
743722010034	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722010035	N-terminal plug; other site
743722010036	ligand-binding site [chemical binding]; other site
743722010037	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
743722010038	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
743722010039	intersubunit interface [polypeptide binding]; other site
743722010040	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
743722010041	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
743722010042	ABC-ATPase subunit  interface; other site
743722010043	dimer interface [polypeptide binding]; other site
743722010044	putative PBP binding regions; other site
743722010045	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
743722010046	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
743722010047	Walker A/P-loop; other site
743722010048	ATP binding site [chemical binding]; other site
743722010049	Q-loop/lid; other site
743722010050	ABC transporter signature motif; other site
743722010051	Walker B; other site
743722010052	D-loop; other site
743722010053	H-loop/switch region; other site
743722010054	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722010055	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722010056	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743722010057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722010058	S-adenosylmethionine binding site [chemical binding]; other site
743722010059	Amino acid permease; Region: AA_permease_2; pfam13520
743722010060	Condensation domain; Region: Condensation; pfam00668
743722010061	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
743722010062	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
743722010063	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
743722010064	active site
743722010065	TDP-binding site; other site
743722010066	acceptor substrate-binding pocket; other site
743722010067	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
743722010068	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
743722010069	active site
743722010070	TDP-binding site; other site
743722010071	acceptor substrate-binding pocket; other site
743722010072	homodimer interface [polypeptide binding]; other site
743722010073	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743722010074	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722010075	hypothetical protein; Provisional; Region: PRK11770
743722010076	Domain of unknown function (DUF307); Region: DUF307; pfam03733
743722010077	Domain of unknown function (DUF307); Region: DUF307; pfam03733
743722010078	Domain of unknown function (DUF4202); Region: DUF4202; pfam13875
743722010079	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
743722010080	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010081	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722010082	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722010083	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
743722010084	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
743722010085	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722010086	Histidine kinase; Region: HisKA_3; pfam07730
743722010087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722010088	ATP binding site [chemical binding]; other site
743722010089	Mg2+ binding site [ion binding]; other site
743722010090	G-X-G motif; other site
743722010091	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722010092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010093	short chain dehydrogenase; Provisional; Region: PRK06139
743722010094	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
743722010095	putative NAD(P) binding site [chemical binding]; other site
743722010096	active site
743722010097	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
743722010098	dimerization interface [polypeptide binding]; other site
743722010099	metal binding site [ion binding]; metal-binding site
743722010100	Protein of unknown function (DUF1264); Region: DUF1264; pfam06884
743722010101	Competence-damaged protein; Region: CinA; pfam02464
743722010102	Domain of unknown function DUF20; Region: UPF0118; pfam01594
743722010103	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
743722010104	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
743722010105	MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242
743722010106	trimer interface [polypeptide binding]; other site
743722010107	dimer interface [polypeptide binding]; other site
743722010108	putative active site [active]
743722010109	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
743722010110	MPT binding site; other site
743722010111	trimer interface [polypeptide binding]; other site
743722010112	hypothetical protein; Validated; Region: PRK07411
743722010113	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
743722010114	ATP binding site [chemical binding]; other site
743722010115	substrate interface [chemical binding]; other site
743722010116	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722010117	active site residue [active]
743722010118	Ubiquitin-like proteins; Region: UBQ; cl00155
743722010119	charged pocket; other site
743722010120	hydrophobic patch; other site
743722010121	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743722010122	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
743722010123	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
743722010124	dimer interface [polypeptide binding]; other site
743722010125	putative functional site; other site
743722010126	putative MPT binding site; other site
743722010127	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
743722010128	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722010129	FeS/SAM binding site; other site
743722010130	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
743722010131	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
743722010132	Ligand binding site; other site
743722010133	metal-binding site
743722010134	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
743722010135	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
743722010136	XdhC Rossmann domain; Region: XdhC_C; pfam13478
743722010137	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
743722010138	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
743722010139	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722010140	catalytic residue [active]
743722010141	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
743722010142	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722010143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010144	active site
743722010145	phosphorylation site [posttranslational modification]
743722010146	intermolecular recognition site; other site
743722010147	dimerization interface [polypeptide binding]; other site
743722010148	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722010149	DNA binding residues [nucleotide binding]
743722010150	dimerization interface [polypeptide binding]; other site
743722010151	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
743722010152	PAS domain; Region: PAS_9; pfam13426
743722010153	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722010154	Histidine kinase; Region: HisKA_3; pfam07730
743722010155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722010156	ATP binding site [chemical binding]; other site
743722010157	Mg2+ binding site [ion binding]; other site
743722010158	G-X-G motif; other site
743722010159	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
743722010160	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
743722010161	nitrite reductase subunit NirD; Provisional; Region: PRK14989
743722010162	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722010163	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
743722010164	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
743722010165	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743722010166	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
743722010167	homodimer interface [polypeptide binding]; other site
743722010168	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
743722010169	active site
743722010170	SAM binding site [chemical binding]; other site
743722010171	homodimer interface [polypeptide binding]; other site
743722010172	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
743722010173	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
743722010174	dimer interface [polypeptide binding]; other site
743722010175	putative functional site; other site
743722010176	putative MPT binding site; other site
743722010177	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
743722010178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010179	putative substrate translocation pore; other site
743722010180	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
743722010181	[4Fe-4S] binding site [ion binding]; other site
743722010182	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
743722010183	molybdopterin cofactor binding site; other site
743722010184	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
743722010185	molybdopterin cofactor binding site; other site
743722010186	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
743722010187	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
743722010188	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
743722010189	Rubredoxin; Region: Rubredoxin; pfam00301
743722010190	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
743722010191	iron binding site [ion binding]; other site
743722010192	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722010193	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722010194	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722010195	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722010196	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722010197	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722010198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010199	Walker A/P-loop; other site
743722010200	ATP binding site [chemical binding]; other site
743722010201	Q-loop/lid; other site
743722010202	ABC transporter signature motif; other site
743722010203	Walker B; other site
743722010204	D-loop; other site
743722010205	H-loop/switch region; other site
743722010206	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722010207	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722010208	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010209	Walker A/P-loop; other site
743722010210	ATP binding site [chemical binding]; other site
743722010211	Q-loop/lid; other site
743722010212	ABC transporter signature motif; other site
743722010213	Walker B; other site
743722010214	D-loop; other site
743722010215	H-loop/switch region; other site
743722010216	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
743722010217	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
743722010218	major facilitator superfamily transporter; Provisional; Region: PRK05122
743722010219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010220	putative substrate translocation pore; other site
743722010221	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
743722010222	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743722010223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010224	Walker A/P-loop; other site
743722010225	ATP binding site [chemical binding]; other site
743722010226	Q-loop/lid; other site
743722010227	ABC transporter signature motif; other site
743722010228	Walker B; other site
743722010229	D-loop; other site
743722010230	H-loop/switch region; other site
743722010231	hypothetical protein; Region: PHA00476
743722010232	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
743722010233	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
743722010234	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722010235	Active site serine [active]
743722010236	Putative carbohydrate binding domain; Region: CHB_HEX; cl03918
743722010237	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
743722010238	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
743722010239	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
743722010240	active site
743722010241	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
743722010242	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
743722010243	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
743722010244	MgtC family; Region: MgtC; pfam02308
743722010245	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
743722010246	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
743722010247	aromatic amino acid transporter; Provisional; Region: PRK10238
743722010248	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
743722010249	substrate binding site [chemical binding]; other site
743722010250	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
743722010251	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722010252	putative active site [active]
743722010253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722010254	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722010255	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722010256	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743722010257	classical (c) SDRs; Region: SDR_c; cd05233
743722010258	NAD(P) binding site [chemical binding]; other site
743722010259	active site
743722010260	Response regulator receiver domain; Region: Response_reg; pfam00072
743722010261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010262	active site
743722010263	phosphorylation site [posttranslational modification]
743722010264	intermolecular recognition site; other site
743722010265	dimerization interface [polypeptide binding]; other site
743722010266	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
743722010267	Chloramphenicol acetyltransferase; Region: CAT; cl02008
743722010268	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
743722010269	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
743722010270	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722010271	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
743722010272	EamA-like transporter family; Region: EamA; pfam00892
743722010273	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
743722010274	EamA-like transporter family; Region: EamA; pfam00892
743722010275	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722010276	putative active site [active]
743722010277	heme pocket [chemical binding]; other site
743722010278	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
743722010279	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
743722010280	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
743722010281	catalytic site [active]
743722010282	active site
743722010283	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
743722010284	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
743722010285	dimerization interface [polypeptide binding]; other site
743722010286	metal binding site [ion binding]; metal-binding site
743722010287	transferase, transferring glycosyl groups; Region: PLN02939
743722010288	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
743722010289	FRG domain; Region: FRG; pfam08867
743722010290	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
743722010291	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743722010292	NAD binding site [chemical binding]; other site
743722010293	catalytic Zn binding site [ion binding]; other site
743722010294	structural Zn binding site [ion binding]; other site
743722010295	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
743722010296	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
743722010297	putative hydrophobic ligand binding site [chemical binding]; other site
743722010298	Protein of unknown function DUF72; Region: DUF72; pfam01904
743722010299	trehalose synthase; Region: treS_nterm; TIGR02456
743722010300	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
743722010301	active site
743722010302	catalytic site [active]
743722010303	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331
743722010304	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
743722010305	active site
743722010306	catalytic site [active]
743722010307	short chain dehydrogenase; Provisional; Region: PRK06701
743722010308	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
743722010309	NAD binding site [chemical binding]; other site
743722010310	metal binding site [ion binding]; metal-binding site
743722010311	active site
743722010312	KTSC domain; Region: KTSC; pfam13619
743722010313	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722010314	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722010315	active site
743722010316	metal binding site [ion binding]; metal-binding site
743722010317	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722010318	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010319	active site
743722010320	phosphorylation site [posttranslational modification]
743722010321	intermolecular recognition site; other site
743722010322	dimerization interface [polypeptide binding]; other site
743722010323	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722010324	DNA binding residues [nucleotide binding]
743722010325	dimerization interface [polypeptide binding]; other site
743722010326	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722010327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010328	active site
743722010329	phosphorylation site [posttranslational modification]
743722010330	intermolecular recognition site; other site
743722010331	dimerization interface [polypeptide binding]; other site
743722010332	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722010333	DNA binding residues [nucleotide binding]
743722010334	dimerization interface [polypeptide binding]; other site
743722010335	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722010336	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
743722010337	Coenzyme A binding pocket [chemical binding]; other site
743722010338	phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172
743722010339	probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885
743722010340	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
743722010341	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
743722010342	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
743722010343	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
743722010344	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
743722010345	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
743722010346	active site
743722010347	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
743722010348	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722010349	putative active site [active]
743722010350	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
743722010351	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722010352	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722010353	putative active site [active]
743722010354	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
743722010355	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
743722010356	substrate binding site [chemical binding]; other site
743722010357	ATP binding site [chemical binding]; other site
743722010358	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
743722010359	active site
743722010360	nucleotide binding site [chemical binding]; other site
743722010361	HIGH motif; other site
743722010362	KMSKS motif; other site
743722010363	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
743722010364	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722010365	active site
743722010366	motif I; other site
743722010367	motif II; other site
743722010368	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
743722010369	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
743722010370	putative ADP-binding pocket [chemical binding]; other site
743722010371	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
743722010372	dimer interface [polypeptide binding]; other site
743722010373	active site
743722010374	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
743722010375	Low affinity iron permease; Region: Iron_permease; pfam04120
743722010376	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
743722010377	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722010378	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722010379	DNA binding residues [nucleotide binding]
743722010380	dimerization interface [polypeptide binding]; other site
743722010381	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
743722010382	Part of AAA domain; Region: AAA_19; pfam13245
743722010383	Family description; Region: UvrD_C_2; pfam13538
743722010384	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722010385	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722010386	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722010387	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743722010388	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
743722010389	putative NAD(P) binding site [chemical binding]; other site
743722010390	catalytic Zn binding site [ion binding]; other site
743722010391	structural Zn binding site [ion binding]; other site
743722010392	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
743722010393	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
743722010394	ligand binding site [chemical binding]; other site
743722010395	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743722010396	non-specific DNA binding site [nucleotide binding]; other site
743722010397	salt bridge; other site
743722010398	sequence-specific DNA binding site [nucleotide binding]; other site
743722010399	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722010400	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722010401	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722010402	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
743722010403	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
743722010404	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
743722010405	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
743722010406	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722010407	active site
743722010408	motif I; other site
743722010409	motif II; other site
743722010410	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
743722010411	RNA binding site [nucleotide binding]; other site
743722010412	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
743722010413	FAD binding domain; Region: FAD_binding_4; pfam01565
743722010414	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
743722010415	transcriptional regulator NanR; Provisional; Region: PRK03837
743722010416	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722010417	DNA-binding site [nucleotide binding]; DNA binding site
743722010418	FCD domain; Region: FCD; pfam07729
743722010419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010420	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722010421	putative substrate translocation pore; other site
743722010422	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
743722010423	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
743722010424	two-component response regulator; Provisional; Region: PRK14084
743722010425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010426	active site
743722010427	phosphorylation site [posttranslational modification]
743722010428	intermolecular recognition site; other site
743722010429	dimerization interface [polypeptide binding]; other site
743722010430	LytTr DNA-binding domain; Region: LytTR; smart00850
743722010431	Histidine kinase; Region: His_kinase; pfam06580
743722010432	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
743722010433	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
743722010434	dimerization interface [polypeptide binding]; other site
743722010435	ATP binding site [chemical binding]; other site
743722010436	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
743722010437	dimerization interface [polypeptide binding]; other site
743722010438	ATP binding site [chemical binding]; other site
743722010439	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
743722010440	putative active site [active]
743722010441	catalytic triad [active]
743722010442	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722010443	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722010444	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722010445	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722010446	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722010447	dimer interface [polypeptide binding]; other site
743722010448	phosphorylation site [posttranslational modification]
743722010449	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722010450	ATP binding site [chemical binding]; other site
743722010451	Mg2+ binding site [ion binding]; other site
743722010452	G-X-G motif; other site
743722010453	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
743722010454	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010455	Walker A/P-loop; other site
743722010456	ATP binding site [chemical binding]; other site
743722010457	Q-loop/lid; other site
743722010458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010459	ABC transporter signature motif; other site
743722010460	Walker B; other site
743722010461	D-loop; other site
743722010462	H-loop/switch region; other site
743722010463	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
743722010464	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
743722010465	active site
743722010466	metal binding site [ion binding]; metal-binding site
743722010467	DNA binding site [nucleotide binding]
743722010468	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
743722010469	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
743722010470	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
743722010471	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
743722010472	glyoxylate reductase; Reviewed; Region: PRK13243
743722010473	dimerization interface [polypeptide binding]; other site
743722010474	ligand binding site [chemical binding]; other site
743722010475	NADP binding site [chemical binding]; other site
743722010476	catalytic site [active]
743722010477	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722010478	DNA-binding site [nucleotide binding]; DNA binding site
743722010479	RNA-binding motif; other site
743722010480	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
743722010481	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
743722010482	dimer interface [polypeptide binding]; other site
743722010483	decamer (pentamer of dimers) interface [polypeptide binding]; other site
743722010484	catalytic triad [active]
743722010485	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
743722010486	putative hydrolase; Provisional; Region: PRK02113
743722010487	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
743722010488	3C cysteine protease (picornain 3C); Region: Peptidase_C3; pfam00548
743722010489	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
743722010490	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
743722010491	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
743722010492	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
743722010493	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
743722010494	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
743722010495	Domain of unknown function (DUF4397); Region: DUF4397; pfam14344
743722010496	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
743722010497	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743722010498	ATP binding site [chemical binding]; other site
743722010499	Mg++ binding site [ion binding]; other site
743722010500	motif III; other site
743722010501	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722010502	nucleotide binding region [chemical binding]; other site
743722010503	ATP-binding site [chemical binding]; other site
743722010504	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
743722010505	RNA binding site [nucleotide binding]; other site
743722010506	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
743722010507	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
743722010508	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
743722010509	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
743722010510	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
743722010511	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722010512	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722010513	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722010514	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010515	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722010516	gliding motility-associated protein GldC; Region: GldC; TIGR03515
743722010517	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
743722010518	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
743722010519	ATP binding site [chemical binding]; other site
743722010520	Mg++ binding site [ion binding]; other site
743722010521	motif III; other site
743722010522	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
743722010523	nucleotide binding region [chemical binding]; other site
743722010524	ATP-binding site [chemical binding]; other site
743722010525	dihydroorotase; Reviewed; Region: PRK09236
743722010526	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722010527	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
743722010528	active site
743722010529	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
743722010530	dimer interface [polypeptide binding]; other site
743722010531	catalytic triad [active]
743722010532	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
743722010533	putative active site [active]
743722010534	Zn binding site [ion binding]; other site
743722010535	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
743722010536	NlpC/P60 family; Region: NLPC_P60; pfam00877
743722010537	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
743722010538	active site
743722010539	dimer interface [polypeptide binding]; other site
743722010540	catalytic nucleophile [active]
743722010541	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
743722010542	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
743722010543	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
743722010544	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
743722010545	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
743722010546	6-phosphofructokinase; Provisional; Region: PRK03202
743722010547	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
743722010548	active site
743722010549	ADP/pyrophosphate binding site [chemical binding]; other site
743722010550	dimerization interface [polypeptide binding]; other site
743722010551	allosteric effector site; other site
743722010552	fructose-1,6-bisphosphate binding site; other site
743722010553	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
743722010554	nudix motif; other site
743722010555	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
743722010556	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
743722010557	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
743722010558	Lumazine binding domain; Region: Lum_binding; pfam00677
743722010559	Lumazine binding domain; Region: Lum_binding; pfam00677
743722010560	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722010561	putative substrate translocation pore; other site
743722010562	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722010563	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722010564	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722010565	DNA binding site [nucleotide binding]
743722010566	domain linker motif; other site
743722010567	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722010568	dimerization interface [polypeptide binding]; other site
743722010569	ligand binding site [chemical binding]; other site
743722010570	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722010571	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722010572	SusD family; Region: SusD; pfam07980
743722010573	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010574	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722010575	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722010576	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722010577	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
743722010578	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
743722010579	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
743722010580	active site
743722010581	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
743722010582	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
743722010583	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
743722010584	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
743722010585	active site
743722010586	HIGH motif; other site
743722010587	dimer interface [polypeptide binding]; other site
743722010588	KMSKS motif; other site
743722010589	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
743722010590	RNA binding surface [nucleotide binding]; other site
743722010591	amino acid transporter; Region: 2A0306; TIGR00909
743722010592	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
743722010593	K+ potassium transporter; Region: K_trans; pfam02705
743722010594	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
743722010595	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
743722010596	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
743722010597	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
743722010598	Peptidase family M23; Region: Peptidase_M23; pfam01551
743722010599	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
743722010600	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
743722010601	catalytic triad [active]
743722010602	transketolase; Reviewed; Region: PRK05899
743722010603	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
743722010604	TPP-binding site [chemical binding]; other site
743722010605	dimer interface [polypeptide binding]; other site
743722010606	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
743722010607	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
743722010608	PYR/PP interface [polypeptide binding]; other site
743722010609	dimer interface [polypeptide binding]; other site
743722010610	TPP binding site [chemical binding]; other site
743722010611	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
743722010612	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
743722010613	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722010614	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722010615	DNA binding residues [nucleotide binding]
743722010616	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
743722010617	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743722010618	inhibitor-cofactor binding pocket; inhibition site
743722010619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722010620	catalytic residue [active]
743722010621	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722010622	catalytic residues [active]
743722010623	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
743722010624	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743722010625	active site
743722010626	catalytic site [active]
743722010627	substrate binding site [chemical binding]; other site
743722010628	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
743722010629	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
743722010630	active site
743722010631	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
743722010632	generic binding surface II; other site
743722010633	generic binding surface I; other site
743722010634	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722010635	Two component regulator propeller; Region: Reg_prop; pfam07494
743722010636	Two component regulator propeller; Region: Reg_prop; pfam07494
743722010637	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722010638	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722010639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722010640	dimer interface [polypeptide binding]; other site
743722010641	phosphorylation site [posttranslational modification]
743722010642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722010643	ATP binding site [chemical binding]; other site
743722010644	Mg2+ binding site [ion binding]; other site
743722010645	G-X-G motif; other site
743722010646	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
743722010647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010648	active site
743722010649	phosphorylation site [posttranslational modification]
743722010650	intermolecular recognition site; other site
743722010651	dimerization interface [polypeptide binding]; other site
743722010652	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722010653	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
743722010654	PA14 domain; Region: PA14; cl08459
743722010655	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
743722010656	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
743722010657	putative active site [active]
743722010658	putative catalytic site [active]
743722010659	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722010660	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010661	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722010662	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722010663	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722010664	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722010665	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722010666	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722010667	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722010668	Family of unknown function (DUF490); Region: DUF490; pfam04357
743722010669	Family of unknown function (DUF490); Region: DUF490; pfam04357
743722010670	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
743722010671	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722010672	malate dehydrogenase; Reviewed; Region: PRK06223
743722010673	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
743722010674	dimer interface [polypeptide binding]; other site
743722010675	NAD(P) binding site [chemical binding]; other site
743722010676	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743722010677	substrate binding site [chemical binding]; other site
743722010678	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
743722010679	catalytic motif [active]
743722010680	Catalytic residue [active]
743722010681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722010682	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
743722010683	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
743722010684	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
743722010685	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
743722010686	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
743722010687	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
743722010688	putative catalytic site [active]
743722010689	putative metal binding site [ion binding]; other site
743722010690	putative phosphate binding site [ion binding]; other site
743722010691	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010692	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
743722010693	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722010694	EamA-like transporter family; Region: EamA; pfam00892
743722010695	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
743722010696	EamA-like transporter family; Region: EamA; pfam00892
743722010697	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
743722010698	putative active site [active]
743722010699	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722010700	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722010701	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722010702	active site
743722010703	catalytic tetrad [active]
743722010704	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
743722010705	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
743722010706	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
743722010707	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
743722010708	beta-galactosidase; Region: BGL; TIGR03356
743722010709	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
743722010710	Protein of unknown function (DUF962); Region: DUF962; cl01879
743722010711	phosphodiesterase; Provisional; Region: PRK12704
743722010712	KH domain; Region: KH_1; pfam00013
743722010713	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
743722010714	Zn2+ binding site [ion binding]; other site
743722010715	Mg2+ binding site [ion binding]; other site
743722010716	Cell division protein ZapA; Region: ZapA; pfam05164
743722010717	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
743722010718	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
743722010719	putative tRNA-binding site [nucleotide binding]; other site
743722010720	B3/4 domain; Region: B3_4; pfam03483
743722010721	tRNA synthetase B5 domain; Region: B5; pfam03484
743722010722	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
743722010723	dimer interface [polypeptide binding]; other site
743722010724	motif 1; other site
743722010725	motif 3; other site
743722010726	motif 2; other site
743722010727	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
743722010728	hypothetical protein; Reviewed; Region: PRK00024
743722010729	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
743722010730	MPN+ (JAMM) motif; other site
743722010731	Zinc-binding site [ion binding]; other site
743722010732	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722010733	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
743722010734	Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981
743722010735	Zn binding site [ion binding]; other site
743722010736	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
743722010737	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722010738	N-terminal plug; other site
743722010739	ligand-binding site [chemical binding]; other site
743722010740	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
743722010741	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
743722010742	xylose isomerase; Provisional; Region: PRK05474
743722010743	xylose isomerase; Region: xylose_isom_A; TIGR02630
743722010744	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722010745	L-fuculokinase; Region: fuculo_kin_coli; TIGR02628
743722010746	nucleotide binding site [chemical binding]; other site
743722010747	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722010748	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722010749	DNA binding site [nucleotide binding]
743722010750	domain linker motif; other site
743722010751	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722010752	dimerization interface [polypeptide binding]; other site
743722010753	ligand binding site [chemical binding]; other site
743722010754	Outer membrane efflux protein; Region: OEP; pfam02321
743722010755	Outer membrane efflux protein; Region: OEP; pfam02321
743722010756	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722010757	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
743722010758	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722010759	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
743722010760	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
743722010761	MgtE intracellular N domain; Region: MgtE_N; pfam03448
743722010762	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
743722010763	Divalent cation transporter; Region: MgtE; pfam01769
743722010764	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
743722010765	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
743722010766	Sulfate transporter family; Region: Sulfate_transp; pfam00916
743722010767	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
743722010768	active site clefts [active]
743722010769	zinc binding site [ion binding]; other site
743722010770	dimer interface [polypeptide binding]; other site
743722010771	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
743722010772	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722010773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743722010774	dimerization interface [polypeptide binding]; other site
743722010775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722010776	dimer interface [polypeptide binding]; other site
743722010777	phosphorylation site [posttranslational modification]
743722010778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722010779	ATP binding site [chemical binding]; other site
743722010780	Mg2+ binding site [ion binding]; other site
743722010781	G-X-G motif; other site
743722010782	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722010783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010784	active site
743722010785	phosphorylation site [posttranslational modification]
743722010786	intermolecular recognition site; other site
743722010787	dimerization interface [polypeptide binding]; other site
743722010788	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722010789	DNA binding site [nucleotide binding]
743722010790	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
743722010791	elongation factor G; Reviewed; Region: PRK12739
743722010792	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
743722010793	G1 box; other site
743722010794	putative GEF interaction site [polypeptide binding]; other site
743722010795	GTP/Mg2+ binding site [chemical binding]; other site
743722010796	Switch I region; other site
743722010797	G2 box; other site
743722010798	G3 box; other site
743722010799	Switch II region; other site
743722010800	G4 box; other site
743722010801	G5 box; other site
743722010802	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
743722010803	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
743722010804	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
743722010805	30S ribosomal protein S7; Validated; Region: PRK05302
743722010806	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
743722010807	S17 interaction site [polypeptide binding]; other site
743722010808	S8 interaction site; other site
743722010809	16S rRNA interaction site [nucleotide binding]; other site
743722010810	streptomycin interaction site [chemical binding]; other site
743722010811	23S rRNA interaction site [nucleotide binding]; other site
743722010812	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
743722010813	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
743722010814	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722010815	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
743722010816	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
743722010817	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
743722010818	dimerization interface [polypeptide binding]; other site
743722010819	ATP binding site [chemical binding]; other site
743722010820	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
743722010821	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
743722010822	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
743722010823	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
743722010824	Cation efflux family; Region: Cation_efflux; pfam01545
743722010825	aspartate aminotransferase; Provisional; Region: PRK05764
743722010826	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722010827	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722010828	homodimer interface [polypeptide binding]; other site
743722010829	catalytic residue [active]
743722010830	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722010831	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722010832	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
743722010833	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722010834	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722010835	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722010836	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
743722010837	FtsX-like permease family; Region: FtsX; pfam02687
743722010838	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
743722010839	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
743722010840	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
743722010841	substrate binding site; other site
743722010842	dimer interface; other site
743722010843	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
743722010844	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
743722010845	active site
743722010846	intersubunit interface [polypeptide binding]; other site
743722010847	zinc binding site [ion binding]; other site
743722010848	Na+ binding site [ion binding]; other site
743722010849	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
743722010850	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
743722010851	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
743722010852	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
743722010853	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722010854	catalytic residue [active]
743722010855	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
743722010856	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
743722010857	active site
743722010858	substrate binding site [chemical binding]; other site
743722010859	metal binding site [ion binding]; metal-binding site
743722010860	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
743722010861	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
743722010862	active site
743722010863	ZIP Zinc transporter; Region: Zip; pfam02535
743722010864	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722010865	MarR family; Region: MarR_2; pfam12802
743722010866	MarR family; Region: MarR_2; cl17246
743722010867	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
743722010868	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722010869	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
743722010870	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
743722010871	CoA-binding site [chemical binding]; other site
743722010872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
743722010873	Preprotein translocase subunit; Region: YajC; pfam02699
743722010874	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
743722010875	transcription antitermination factor NusB; Region: nusB; TIGR01951
743722010876	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
743722010877	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
743722010878	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
743722010879	NAD binding site [chemical binding]; other site
743722010880	Phe binding site; other site
743722010881	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722010882	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722010883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722010884	Walker A/P-loop; other site
743722010885	ATP binding site [chemical binding]; other site
743722010886	Q-loop/lid; other site
743722010887	ABC transporter signature motif; other site
743722010888	Walker B; other site
743722010889	D-loop; other site
743722010890	H-loop/switch region; other site
743722010891	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
743722010892	ligand binding site [chemical binding]; other site
743722010893	active site
743722010894	UGI interface [polypeptide binding]; other site
743722010895	catalytic site [active]
743722010896	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
743722010897	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722010898	putative DNA binding site [nucleotide binding]; other site
743722010899	putative Zn2+ binding site [ion binding]; other site
743722010900	AsnC family; Region: AsnC_trans_reg; pfam01037
743722010901	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
743722010902	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
743722010903	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
743722010904	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
743722010905	catalytic residue [active]
743722010906	FeS assembly protein SufD; Region: sufD; TIGR01981
743722010907	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
743722010908	FeS assembly ATPase SufC; Region: sufC; TIGR01978
743722010909	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
743722010910	Walker A/P-loop; other site
743722010911	ATP binding site [chemical binding]; other site
743722010912	Q-loop/lid; other site
743722010913	ABC transporter signature motif; other site
743722010914	Walker B; other site
743722010915	D-loop; other site
743722010916	H-loop/switch region; other site
743722010917	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
743722010918	putative ABC transporter; Region: ycf24; CHL00085
743722010919	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
743722010920	active site
743722010921	dimer interface [polypeptide binding]; other site
743722010922	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
743722010923	transcription termination factor Rho; Provisional; Region: PRK12608
743722010924	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
743722010925	RNA binding site [nucleotide binding]; other site
743722010926	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
743722010927	multimer interface [polypeptide binding]; other site
743722010928	Walker A motif; other site
743722010929	ATP binding site [chemical binding]; other site
743722010930	Walker B motif; other site
743722010931	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
743722010932	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
743722010933	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
743722010934	catalytic center binding site [active]
743722010935	ATP binding site [chemical binding]; other site
743722010936	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
743722010937	tandem repeat interface [polypeptide binding]; other site
743722010938	oligomer interface [polypeptide binding]; other site
743722010939	active site residues [active]
743722010940	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
743722010941	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
743722010942	tandem repeat interface [polypeptide binding]; other site
743722010943	oligomer interface [polypeptide binding]; other site
743722010944	active site residues [active]
743722010945	hypothetical protein; Provisional; Region: PRK08609
743722010946	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
743722010947	metal binding triad [ion binding]; metal-binding site
743722010948	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
743722010949	active site
743722010950	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
743722010951	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
743722010952	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
743722010953	putative active site [active]
743722010954	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
743722010955	catalytic core [active]
743722010956	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
743722010957	active site
743722010958	catalytic residues [active]
743722010959	Mechanosensitive ion channel; Region: MS_channel; pfam00924
743722010960	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
743722010961	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
743722010962	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
743722010963	putative active site [active]
743722010964	catalytic site [active]
743722010965	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
743722010966	putative active site [active]
743722010967	catalytic site [active]
743722010968	GLPGLI family protein; Region: GLPGLI; TIGR01200
743722010969	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722010970	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722010971	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722010972	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
743722010973	Zn binding site [ion binding]; other site
743722010974	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
743722010975	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
743722010976	active site
743722010977	Zn binding site [ion binding]; other site
743722010978	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722010979	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722010980	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722010981	DNA binding residues [nucleotide binding]
743722010982	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
743722010983	Strictosidine synthase; Region: Str_synth; pfam03088
743722010984	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743722010985	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
743722010986	substrate binding pocket [chemical binding]; other site
743722010987	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722010988	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722010989	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722010990	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
743722010991	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
743722010992	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
743722010993	dimer interface [polypeptide binding]; other site
743722010994	Response regulator receiver domain; Region: Response_reg; pfam00072
743722010995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722010996	active site
743722010997	phosphorylation site [posttranslational modification]
743722010998	intermolecular recognition site; other site
743722010999	dimerization interface [polypeptide binding]; other site
743722011000	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722011001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011002	active site
743722011003	phosphorylation site [posttranslational modification]
743722011004	intermolecular recognition site; other site
743722011005	dimerization interface [polypeptide binding]; other site
743722011006	LytTr DNA-binding domain; Region: LytTR; smart00850
743722011007	Histidine kinase; Region: His_kinase; pfam06580
743722011008	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
743722011009	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
743722011010	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
743722011011	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
743722011012	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722011013	motif II; other site
743722011014	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
743722011015	Uncharacterized conserved protein [Function unknown]; Region: COG2898
743722011016	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
743722011017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722011018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011019	active site
743722011020	phosphorylation site [posttranslational modification]
743722011021	intermolecular recognition site; other site
743722011022	dimerization interface [polypeptide binding]; other site
743722011023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722011024	DNA binding site [nucleotide binding]
743722011025	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722011026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722011027	dimer interface [polypeptide binding]; other site
743722011028	phosphorylation site [posttranslational modification]
743722011029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011030	ATP binding site [chemical binding]; other site
743722011031	Mg2+ binding site [ion binding]; other site
743722011032	G-X-G motif; other site
743722011033	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722011034	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722011035	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722011036	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722011037	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722011038	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
743722011039	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
743722011040	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
743722011041	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
743722011042	active site
743722011043	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
743722011044	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
743722011045	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722011046	FeS/SAM binding site; other site
743722011047	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
743722011048	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
743722011049	Melibiase; Region: Melibiase; pfam02065
743722011050	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743722011051	RibD C-terminal domain; Region: RibD_C; cl17279
743722011052	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722011053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011054	active site
743722011055	phosphorylation site [posttranslational modification]
743722011056	intermolecular recognition site; other site
743722011057	dimerization interface [polypeptide binding]; other site
743722011058	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722011059	DNA binding site [nucleotide binding]
743722011060	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722011061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722011062	dimer interface [polypeptide binding]; other site
743722011063	phosphorylation site [posttranslational modification]
743722011064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011065	ATP binding site [chemical binding]; other site
743722011066	Mg2+ binding site [ion binding]; other site
743722011067	G-X-G motif; other site
743722011068	GLPGLI family protein; Region: GLPGLI; TIGR01200
743722011069	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011070	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011071	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
743722011072	putative active site [active]
743722011073	Zn binding site [ion binding]; other site
743722011074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743722011075	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722011076	LysR substrate binding domain; Region: LysR_substrate; pfam03466
743722011077	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
743722011078	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
743722011079	dimer interface [polypeptide binding]; other site
743722011080	active site
743722011081	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011082	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011083	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722011084	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
743722011085	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
743722011086	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
743722011087	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
743722011088	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
743722011089	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
743722011090	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
743722011091	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
743722011092	Walker A/P-loop; other site
743722011093	ATP binding site [chemical binding]; other site
743722011094	Q-loop/lid; other site
743722011095	ABC transporter signature motif; other site
743722011096	Walker B; other site
743722011097	D-loop; other site
743722011098	H-loop/switch region; other site
743722011099	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
743722011100	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
743722011101	Walker A/P-loop; other site
743722011102	ATP binding site [chemical binding]; other site
743722011103	Q-loop/lid; other site
743722011104	ABC transporter signature motif; other site
743722011105	Walker B; other site
743722011106	D-loop; other site
743722011107	H-loop/switch region; other site
743722011108	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
743722011109	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
743722011110	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722011111	Outer membrane efflux protein; Region: OEP; pfam02321
743722011112	Outer membrane efflux protein; Region: OEP; pfam02321
743722011113	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722011114	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722011115	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722011116	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722011117	Walker A motif; other site
743722011118	ATP binding site [chemical binding]; other site
743722011119	Walker B motif; other site
743722011120	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722011121	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722011122	Integrase core domain; Region: rve; pfam00665
743722011123	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
743722011124	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722011125	DNA-binding site [nucleotide binding]; DNA binding site
743722011126	RNA-binding motif; other site
743722011127	ATP cone domain; Region: ATP-cone; pfam03477
743722011128	Restriction endonuclease; Region: Mrr_cat; pfam04471
743722011129	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722011130	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
743722011131	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
743722011132	putative active site [active]
743722011133	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722011134	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011135	Walker A/P-loop; other site
743722011136	ATP binding site [chemical binding]; other site
743722011137	Q-loop/lid; other site
743722011138	ABC transporter signature motif; other site
743722011139	Walker B; other site
743722011140	D-loop; other site
743722011141	H-loop/switch region; other site
743722011142	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743722011143	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
743722011144	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
743722011145	active site
743722011146	nucleophile elbow; other site
743722011147	DinB superfamily; Region: DinB_2; pfam12867
743722011148	Predicted ATPase [General function prediction only]; Region: COG3911
743722011149	AAA domain; Region: AAA_28; pfam13521
743722011150	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
743722011151	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
743722011152	SnoaL-like domain; Region: SnoaL_3; pfam13474
743722011153	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
743722011154	Active_site [active]
743722011155	Protein of unknown function (DUF763); Region: DUF763; pfam05559
743722011156	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722011157	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
743722011158	dimer interface [polypeptide binding]; other site
743722011159	putative metal binding site [ion binding]; other site
743722011160	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
743722011161	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011162	putative substrate translocation pore; other site
743722011163	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
743722011164	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722011165	FeS/SAM binding site; other site
743722011166	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722011167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011168	NAD(P) binding site [chemical binding]; other site
743722011169	active site
743722011170	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
743722011171	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
743722011172	homodimer interface [polypeptide binding]; other site
743722011173	putative substrate binding pocket [chemical binding]; other site
743722011174	diiron center [ion binding]; other site
743722011175	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
743722011176	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
743722011177	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
743722011178	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722011179	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
743722011180	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722011181	active site
743722011182	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
743722011183	Domain of unknown function (DUF1704); Region: DUF1704; cl06858
743722011184	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
743722011185	glutathione synthetase; Provisional; Region: PRK12458
743722011186	ATP-grasp domain; Region: ATP-grasp_4; cl17255
743722011187	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
743722011188	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
743722011189	FAD binding pocket [chemical binding]; other site
743722011190	conserved FAD binding motif [chemical binding]; other site
743722011191	phosphate binding motif [ion binding]; other site
743722011192	beta-alpha-beta structure motif; other site
743722011193	NAD binding pocket [chemical binding]; other site
743722011194	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722011195	catalytic loop [active]
743722011196	iron binding site [ion binding]; other site
743722011197	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722011198	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722011199	binding surface
743722011200	TPR motif; other site
743722011201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722011202	binding surface
743722011203	TPR motif; other site
743722011204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722011205	Histidine kinase; Region: HisKA_3; pfam07730
743722011206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011207	ATP binding site [chemical binding]; other site
743722011208	Mg2+ binding site [ion binding]; other site
743722011209	G-X-G motif; other site
743722011210	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722011211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011212	active site
743722011213	phosphorylation site [posttranslational modification]
743722011214	intermolecular recognition site; other site
743722011215	dimerization interface [polypeptide binding]; other site
743722011216	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722011217	DNA binding residues [nucleotide binding]
743722011218	dimerization interface [polypeptide binding]; other site
743722011219	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
743722011220	Transglycosylase; Region: Transgly; pfam00912
743722011221	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
743722011222	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
743722011223	MG2 domain; Region: A2M_N; pfam01835
743722011224	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
743722011225	Alpha-2-macroglobulin family; Region: A2M; pfam00207
743722011226	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
743722011227	surface patch; other site
743722011228	thioester region; other site
743722011229	specificity defining residues; other site
743722011230	DoxX; Region: DoxX; pfam07681
743722011231	cysteine synthase B; Region: cysM; TIGR01138
743722011232	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
743722011233	dimer interface [polypeptide binding]; other site
743722011234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722011235	catalytic residue [active]
743722011236	serine O-acetyltransferase; Region: cysE; TIGR01172
743722011237	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
743722011238	trimer interface [polypeptide binding]; other site
743722011239	active site
743722011240	substrate binding site [chemical binding]; other site
743722011241	CoA binding site [chemical binding]; other site
743722011242	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
743722011243	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
743722011244	putative active site [active]
743722011245	putative FMN binding site [chemical binding]; other site
743722011246	putative substrate binding site [chemical binding]; other site
743722011247	putative catalytic residue [active]
743722011248	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722011249	dimerization interface [polypeptide binding]; other site
743722011250	putative DNA binding site [nucleotide binding]; other site
743722011251	putative Zn2+ binding site [ion binding]; other site
743722011252	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
743722011253	active site
743722011254	dinuclear metal binding site [ion binding]; other site
743722011255	dimerization interface [polypeptide binding]; other site
743722011256	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
743722011257	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
743722011258	trmE is a tRNA modification GTPase; Region: trmE; cd04164
743722011259	G1 box; other site
743722011260	GTP/Mg2+ binding site [chemical binding]; other site
743722011261	Switch I region; other site
743722011262	G2 box; other site
743722011263	Switch II region; other site
743722011264	G3 box; other site
743722011265	G4 box; other site
743722011266	G5 box; other site
743722011267	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
743722011268	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
743722011269	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743722011270	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722011271	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722011272	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722011273	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
743722011274	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
743722011275	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
743722011276	NodB motif; other site
743722011277	putative active site [active]
743722011278	putative catalytic site [active]
743722011279	putative Zn binding site [ion binding]; other site
743722011280	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
743722011281	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011282	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722011283	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722011284	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409
743722011285	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722011286	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
743722011287	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
743722011288	tetramer interface [polypeptide binding]; other site
743722011289	active site
743722011290	Mg2+/Mn2+ binding site [ion binding]; other site
743722011291	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
743722011292	methylcitrate synthase; Provisional; Region: PRK12351
743722011293	oxalacetate binding site [chemical binding]; other site
743722011294	citrylCoA binding site [chemical binding]; other site
743722011295	coenzyme A binding site [chemical binding]; other site
743722011296	catalytic triad [active]
743722011297	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
743722011298	2-methylcitrate dehydratase; Region: prpD; TIGR02330
743722011299	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722011300	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
743722011301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011302	putative substrate translocation pore; other site
743722011303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722011305	TPR motif; other site
743722011306	binding surface
743722011307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722011308	binding surface
743722011309	TPR motif; other site
743722011310	TPR repeat; Region: TPR_11; pfam13414
743722011311	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722011312	binding surface
743722011313	TPR motif; other site
743722011314	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722011315	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
743722011316	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011317	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011318	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
743722011319	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
743722011320	putative NAD(P) binding site [chemical binding]; other site
743722011321	dimer interface [polypeptide binding]; other site
743722011322	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722011323	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011325	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
743722011326	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
743722011327	substrate binding site [chemical binding]; other site
743722011328	active site
743722011329	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
743722011330	metal binding site [ion binding]; metal-binding site
743722011331	ligand binding site [chemical binding]; other site
743722011332	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
743722011333	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
743722011334	FMN binding site [chemical binding]; other site
743722011335	substrate binding site [chemical binding]; other site
743722011336	putative catalytic residue [active]
743722011337	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011338	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
743722011339	ligand binding site [chemical binding]; other site
743722011340	flexible hinge region; other site
743722011341	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011342	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011343	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722011344	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722011345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722011346	Walker A motif; other site
743722011347	ATP binding site [chemical binding]; other site
743722011348	Walker B motif; other site
743722011349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722011350	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
743722011351	DNA-binding interface [nucleotide binding]; DNA binding site
743722011352	Integrase core domain; Region: rve; pfam00665
743722011353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722011354	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
743722011355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
743722011356	Transposase; Region: HTH_Tnp_1; cl17663
743722011357	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722011358	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011359	Predicted membrane protein [Function unknown]; Region: COG2259
743722011360	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722011361	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
743722011362	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743722011363	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722011364	short chain dehydrogenase; Provisional; Region: PRK06914
743722011365	NADP binding site [chemical binding]; other site
743722011366	active site
743722011367	steroid binding site; other site
743722011368	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011370	short chain dehydrogenase; Provisional; Region: PRK06500
743722011371	classical (c) SDRs; Region: SDR_c; cd05233
743722011372	NAD(P) binding site [chemical binding]; other site
743722011373	active site
743722011374	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011375	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011376	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
743722011377	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
743722011378	NADP binding site [chemical binding]; other site
743722011379	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011380	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722011381	dimerization interface [polypeptide binding]; other site
743722011382	putative DNA binding site [nucleotide binding]; other site
743722011383	putative Zn2+ binding site [ion binding]; other site
743722011384	NIPSNAP; Region: NIPSNAP; pfam07978
743722011385	NIPSNAP; Region: NIPSNAP; pfam07978
743722011386	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011387	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011388	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
743722011389	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
743722011390	putative NAD(P) binding site [chemical binding]; other site
743722011391	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
743722011392	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011393	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011394	ligand binding site [chemical binding]; other site
743722011395	short chain dehydrogenase; Provisional; Region: PRK06914
743722011396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011397	NAD(P) binding site [chemical binding]; other site
743722011398	active site
743722011399	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
743722011400	hypothetical protein; Provisional; Region: PRK07588
743722011401	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722011402	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011404	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
743722011405	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722011406	Histidine kinase; Region: HisKA_3; pfam07730
743722011407	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011408	ATP binding site [chemical binding]; other site
743722011409	Mg2+ binding site [ion binding]; other site
743722011410	G-X-G motif; other site
743722011411	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722011412	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722011413	DNA binding residues [nucleotide binding]
743722011414	dimerization interface [polypeptide binding]; other site
743722011415	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
743722011416	FOG: CBS domain [General function prediction only]; Region: COG0517
743722011417	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722011418	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722011419	phosphorylation site [posttranslational modification]
743722011420	dimer interface [polypeptide binding]; other site
743722011421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011422	ATP binding site [chemical binding]; other site
743722011423	Mg2+ binding site [ion binding]; other site
743722011424	G-X-G motif; other site
743722011425	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
743722011426	active site
743722011427	catalytic triad [active]
743722011428	oxyanion hole [active]
743722011429	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
743722011430	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722011431	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011432	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011433	flexible hinge region; other site
743722011434	RibD C-terminal domain; Region: RibD_C; cl17279
743722011435	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743722011436	Sulfatase; Region: Sulfatase; cl17466
743722011437	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722011438	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011439	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011440	flexible hinge region; other site
743722011441	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
743722011442	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722011443	NAD(P) binding site [chemical binding]; other site
743722011444	active site
743722011445	Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120
743722011446	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722011447	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011448	active site
743722011449	phosphorylation site [posttranslational modification]
743722011450	intermolecular recognition site; other site
743722011451	dimerization interface [polypeptide binding]; other site
743722011452	LytTr DNA-binding domain; Region: LytTR; smart00850
743722011453	Histidine kinase; Region: His_kinase; pfam06580
743722011454	CAAX protease self-immunity; Region: Abi; pfam02517
743722011455	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
743722011456	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011457	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011458	ligand binding site [chemical binding]; other site
743722011459	flexible hinge region; other site
743722011460	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743722011461	homotrimer interaction site [polypeptide binding]; other site
743722011462	putative active site [active]
743722011463	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
743722011464	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722011465	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011466	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011467	ligand binding site [chemical binding]; other site
743722011468	flexible hinge region; other site
743722011469	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722011470	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722011472	DNA binding residues [nucleotide binding]
743722011473	FecR protein; Region: FecR; pfam04773
743722011474	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722011475	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011476	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011477	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011478	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722011479	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722011480	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722011481	SusD family; Region: SusD; pfam07980
743722011482	Predicted permeases [General function prediction only]; Region: RarD; COG2962
743722011483	EamA-like transporter family; Region: EamA; pfam00892
743722011484	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722011485	Sulfatase; Region: Sulfatase; pfam00884
743722011486	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722011487	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722011488	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
743722011489	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
743722011490	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722011491	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011492	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011493	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011494	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722011495	MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879
743722011496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011497	putative substrate translocation pore; other site
743722011498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011499	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
743722011500	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722011501	DNA-binding site [nucleotide binding]; DNA binding site
743722011502	UTRA domain; Region: UTRA; pfam07702
743722011503	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722011504	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722011505	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722011506	SusD family; Region: SusD; pfam07980
743722011507	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011508	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011509	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011510	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722011511	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722011512	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
743722011513	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
743722011514	metal-binding site [ion binding]
743722011515	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722011516	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722011517	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
743722011518	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
743722011519	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
743722011520	Soluble P-type ATPase [General function prediction only]; Region: COG4087
743722011521	K+-transporting ATPase, c chain; Region: KdpC; cl00944
743722011522	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
743722011523	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
743722011524	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
743722011525	Ligand Binding Site [chemical binding]; other site
743722011526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
743722011527	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
743722011528	dimerization interface [polypeptide binding]; other site
743722011529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722011530	dimer interface [polypeptide binding]; other site
743722011531	phosphorylation site [posttranslational modification]
743722011532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011533	ATP binding site [chemical binding]; other site
743722011534	Mg2+ binding site [ion binding]; other site
743722011535	G-X-G motif; other site
743722011536	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
743722011537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011538	NAD(P) binding site [chemical binding]; other site
743722011539	active site
743722011540	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011541	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011542	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011543	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722011544	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722011545	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722011546	SusD family; Region: SusD; pfam07980
743722011547	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722011548	DNA-binding site [nucleotide binding]; DNA binding site
743722011549	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722011550	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
743722011551	putative dimerization interface [polypeptide binding]; other site
743722011552	putative ligand binding site [chemical binding]; other site
743722011553	putative transporter; Provisional; Region: PRK10484
743722011554	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
743722011555	Na binding site [ion binding]; other site
743722011556	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011557	Protein of unknown function, DUF486; Region: DUF486; cl01236
743722011558	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
743722011559	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011560	active site
743722011561	phosphorylation site [posttranslational modification]
743722011562	intermolecular recognition site; other site
743722011563	dimerization interface [polypeptide binding]; other site
743722011564	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722011565	ATP binding site [chemical binding]; other site
743722011566	Walker B motif; other site
743722011567	arginine finger; other site
743722011568	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
743722011569	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
743722011570	cyclase homology domain; Region: CHD; cd07302
743722011571	nucleotidyl binding site; other site
743722011572	metal binding site [ion binding]; metal-binding site
743722011573	dimer interface [polypeptide binding]; other site
743722011574	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
743722011575	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
743722011576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011577	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
743722011578	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
743722011579	DNA binding site [nucleotide binding]
743722011580	active site
743722011581	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
743722011582	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
743722011583	ATP binding site [chemical binding]; other site
743722011584	putative Mg++ binding site [ion binding]; other site
743722011585	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
743722011586	AAA domain; Region: AAA_12; pfam13087
743722011587	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
743722011588	putative active site [active]
743722011589	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
743722011590	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
743722011591	active site
743722011592	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
743722011593	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
743722011594	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
743722011595	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
743722011596	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
743722011597	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
743722011598	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
743722011599	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
743722011600	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
743722011601	putative active site [active]
743722011602	Staphylococcal nuclease homologues; Region: SNc; smart00318
743722011603	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
743722011604	Catalytic site; other site
743722011605	Protein of unknown function (DUF419); Region: DUF419; pfam04237
743722011606	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
743722011607	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722011608	catalytic loop [active]
743722011609	iron binding site [ion binding]; other site
743722011610	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
743722011611	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
743722011612	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
743722011613	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722011614	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722011615	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
743722011616	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722011617	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722011618	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722011619	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
743722011620	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011621	putative substrate translocation pore; other site
743722011622	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722011623	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722011624	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722011625	Histidine kinase; Region: HisKA_3; pfam07730
743722011626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722011627	ATP binding site [chemical binding]; other site
743722011628	Mg2+ binding site [ion binding]; other site
743722011629	G-X-G motif; other site
743722011630	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722011631	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722011632	SusD family; Region: SusD; pfam07980
743722011633	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722011634	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011635	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011636	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722011637	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722011638	FecR protein; Region: FecR; pfam04773
743722011639	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722011640	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011641	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722011642	BNR repeat-like domain; Region: BNR_2; pfam13088
743722011643	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
743722011644	Asp-box motif; other site
743722011645	catalytic site [active]
743722011646	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
743722011647	MgtE intracellular N domain; Region: MgtE_N; pfam03448
743722011648	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
743722011649	Divalent cation transporter; Region: MgtE; pfam01769
743722011650	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
743722011651	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
743722011652	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
743722011653	Cytochrome c; Region: Cytochrom_C; pfam00034
743722011654	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
743722011655	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
743722011656	Cu(I) binding site [ion binding]; other site
743722011657	YtkA-like; Region: YtkA; pfam13115
743722011658	Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200
743722011659	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
743722011660	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722011661	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722011662	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
743722011663	active site
743722011664	catalytic triad [active]
743722011665	oxyanion hole [active]
743722011666	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
743722011667	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
743722011668	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
743722011669	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722011670	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722011671	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722011672	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011673	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011674	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722011675	FecR protein; Region: FecR; pfam04773
743722011676	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722011677	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011678	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722011679	DNA binding residues [nucleotide binding]
743722011680	Domain of unknown function (DUF202); Region: DUF202; pfam02656
743722011681	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
743722011682	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722011683	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722011684	FtsX-like permease family; Region: FtsX; pfam02687
743722011685	FtsX-like permease family; Region: FtsX; pfam02687
743722011686	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722011687	Sulfatase; Region: Sulfatase; pfam00884
743722011688	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722011689	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722011690	YCII-related domain; Region: YCII; pfam03795
743722011691	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
743722011692	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011693	Sulfatase; Region: Sulfatase; cl17466
743722011694	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722011695	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
743722011696	EamA-like transporter family; Region: EamA; pfam00892
743722011697	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
743722011698	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722011699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722011700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722011701	Carboxylesterase family; Region: COesterase; pfam00135
743722011702	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743722011703	substrate binding pocket [chemical binding]; other site
743722011704	catalytic triad [active]
743722011705	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743722011706	non-specific DNA binding site [nucleotide binding]; other site
743722011707	salt bridge; other site
743722011708	sequence-specific DNA binding site [nucleotide binding]; other site
743722011709	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
743722011710	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
743722011711	putative metal binding site [ion binding]; other site
743722011712	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
743722011713	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722011714	SusD family; Region: SusD; pfam07980
743722011715	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722011716	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011717	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011718	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011719	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722011720	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722011721	FecR protein; Region: FecR; pfam04773
743722011722	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722011723	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722011724	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011725	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722011726	DNA binding residues [nucleotide binding]
743722011727	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
743722011728	active site triad [active]
743722011729	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
743722011730	homotrimer interaction site [polypeptide binding]; other site
743722011731	putative active site [active]
743722011732	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011733	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011734	ligand binding site [chemical binding]; other site
743722011735	flexible hinge region; other site
743722011736	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011738	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722011739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011740	NAD(P) binding site [chemical binding]; other site
743722011741	active site
743722011742	H+ Antiporter protein; Region: 2A0121; TIGR00900
743722011743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722011744	putative substrate translocation pore; other site
743722011745	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011747	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
743722011748	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
743722011749	FAD binding pocket [chemical binding]; other site
743722011750	conserved FAD binding motif [chemical binding]; other site
743722011751	phosphate binding motif [ion binding]; other site
743722011752	beta-alpha-beta structure motif; other site
743722011753	NAD binding pocket [chemical binding]; other site
743722011754	Transcriptional regulator [Transcription]; Region: LysR; COG0583
743722011755	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
743722011756	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
743722011757	dimerization interface [polypeptide binding]; other site
743722011758	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722011759	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722011760	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722011761	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
743722011762	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011763	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
743722011764	NAD(P) binding site [chemical binding]; other site
743722011765	active site
743722011766	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722011767	MarR family; Region: MarR_2; pfam12802
743722011768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011769	Walker A/P-loop; other site
743722011770	ATP binding site [chemical binding]; other site
743722011771	Q-loop/lid; other site
743722011772	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743722011773	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011774	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
743722011775	Walker A/P-loop; other site
743722011776	ATP binding site [chemical binding]; other site
743722011777	Q-loop/lid; other site
743722011778	ABC transporter signature motif; other site
743722011779	Walker B; other site
743722011780	D-loop; other site
743722011781	H-loop/switch region; other site
743722011782	FtsX-like permease family; Region: FtsX; pfam02687
743722011783	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
743722011784	active site
743722011785	metal binding site [ion binding]; metal-binding site
743722011786	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722011787	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
743722011788	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722011789	FtsX-like permease family; Region: FtsX; pfam02687
743722011790	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722011791	FtsX-like permease family; Region: FtsX; pfam02687
743722011792	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722011793	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722011794	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
743722011795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011796	NAD(P) binding site [chemical binding]; other site
743722011797	active site
743722011798	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
743722011799	short chain dehydrogenase; Provisional; Region: PRK09291
743722011800	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011801	NAD(P) binding site [chemical binding]; other site
743722011802	active site
743722011803	Domain of unknown function (DUF336); Region: DUF336; pfam03928
743722011804	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011805	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011806	Nucleoside Triphosphate Pyrophosphohydrolase EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u6; cd11543
743722011807	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
743722011808	SnoaL-like domain; Region: SnoaL_4; pfam13577
743722011809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011810	Uncharacterized conserved protein [Function unknown]; Region: COG3268
743722011811	NAD(P) binding site [chemical binding]; other site
743722011812	active site
743722011813	short chain dehydrogenase; Provisional; Region: PRK06523
743722011814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011815	NAD(P) binding site [chemical binding]; other site
743722011816	active site
743722011817	short chain dehydrogenase; Provisional; Region: PRK06523
743722011818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722011819	NAD(P) binding site [chemical binding]; other site
743722011820	active site
743722011821	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
743722011822	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722011823	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722011824	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011825	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011826	short chain dehydrogenase; Provisional; Region: PRK06180
743722011827	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722011828	NADP binding site [chemical binding]; other site
743722011829	active site
743722011830	steroid binding site; other site
743722011831	Histidine kinase; Region: His_kinase; pfam06580
743722011832	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722011833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722011834	active site
743722011835	phosphorylation site [posttranslational modification]
743722011836	intermolecular recognition site; other site
743722011837	dimerization interface [polypeptide binding]; other site
743722011838	LytTr DNA-binding domain; Region: LytTR; pfam04397
743722011839	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722011840	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
743722011841	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
743722011842	putative acyl-acceptor binding pocket; other site
743722011843	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
743722011844	dimer interface [polypeptide binding]; other site
743722011845	FMN binding site [chemical binding]; other site
743722011846	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011847	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011848	short chain dehydrogenase; Provisional; Region: PRK06180
743722011849	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722011850	NADP binding site [chemical binding]; other site
743722011851	active site
743722011852	steroid binding site; other site
743722011853	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011854	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011855	ligand binding site [chemical binding]; other site
743722011856	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722011857	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722011858	FtsX-like permease family; Region: FtsX; pfam02687
743722011859	FtsX-like permease family; Region: FtsX; pfam02687
743722011860	short chain dehydrogenase; Provisional; Region: PRK06482
743722011861	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722011862	NADP binding site [chemical binding]; other site
743722011863	active site
743722011864	steroid binding site; other site
743722011865	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011866	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011867	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
743722011868	putative active site [active]
743722011869	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
743722011870	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
743722011871	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
743722011872	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722011873	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743722011874	protein-splicing catalytic site; other site
743722011875	thioester formation/cholesterol transfer; other site
743722011876	Pretoxin HINT domain; Region: PT-HINT; pfam07591
743722011877	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743722011878	protein-splicing catalytic site; other site
743722011879	thioester formation/cholesterol transfer; other site
743722011880	F-box associated region; Region: FBA; pfam04300
743722011881	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011882	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011883	short chain dehydrogenase; Provisional; Region: PRK06180
743722011884	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722011885	NADP binding site [chemical binding]; other site
743722011886	active site
743722011887	steroid binding site; other site
743722011888	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
743722011889	Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512
743722011890	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011891	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011892	ligand binding site [chemical binding]; other site
743722011893	flexible hinge region; other site
743722011894	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
743722011895	AAA domain; Region: AAA_14; pfam13173
743722011896	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722011897	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
743722011898	oligomeric interface; other site
743722011899	putative active site [active]
743722011900	homodimer interface [polypeptide binding]; other site
743722011901	MutS domain III; Region: MutS_III; pfam05192
743722011902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011903	Walker A/P-loop; other site
743722011904	ATP binding site [chemical binding]; other site
743722011905	Q-loop/lid; other site
743722011906	ABC transporter signature motif; other site
743722011907	Walker B; other site
743722011908	D-loop; other site
743722011909	H-loop/switch region; other site
743722011910	short chain dehydrogenase; Provisional; Region: PRK06172
743722011911	classical (c) SDRs; Region: SDR_c; cd05233
743722011912	NAD(P) binding site [chemical binding]; other site
743722011913	active site
743722011914	AAA domain; Region: AAA_14; pfam13173
743722011915	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
743722011916	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
743722011917	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722011918	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722011919	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722011920	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722011921	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722011922	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722011923	DNA binding residues [nucleotide binding]
743722011924	FecR protein; Region: FecR; pfam04773
743722011925	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722011926	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722011927	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722011928	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722011929	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722011930	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722011931	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722011932	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
743722011933	L-lactate permease; Region: Lactate_perm; cl00701
743722011934	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722011935	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722011936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722011937	Walker A motif; other site
743722011938	ATP binding site [chemical binding]; other site
743722011939	Walker B motif; other site
743722011940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722011941	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
743722011942	DNA-binding interface [nucleotide binding]; DNA binding site
743722011943	Integrase core domain; Region: rve; pfam00665
743722011944	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722011945	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722011946	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722011947	catalytic residues [active]
743722011948	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722011949	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011950	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011951	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
743722011952	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
743722011953	putative NAD(P) binding site [chemical binding]; other site
743722011954	homodimer interface [polypeptide binding]; other site
743722011955	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
743722011956	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
743722011957	NmrA-like family; Region: NmrA; pfam05368
743722011958	NADP binding site [chemical binding]; other site
743722011959	active site
743722011960	regulatory binding site [polypeptide binding]; other site
743722011961	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722011962	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722011963	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
743722011964	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722011965	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722011966	ligand binding site [chemical binding]; other site
743722011967	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722011968	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722011969	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011970	Walker A/P-loop; other site
743722011971	ATP binding site [chemical binding]; other site
743722011972	Q-loop/lid; other site
743722011973	ABC transporter signature motif; other site
743722011974	Walker B; other site
743722011975	D-loop; other site
743722011976	H-loop/switch region; other site
743722011977	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
743722011978	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
743722011979	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722011980	Walker A/P-loop; other site
743722011981	ATP binding site [chemical binding]; other site
743722011982	Q-loop/lid; other site
743722011983	ABC transporter signature motif; other site
743722011984	Walker B; other site
743722011985	D-loop; other site
743722011986	H-loop/switch region; other site
743722011987	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722011988	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011989	DinB family; Region: DinB; cl17821
743722011990	DinB superfamily; Region: DinB_2; pfam12867
743722011991	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011992	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722011993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722011994	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
743722011995	Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067
743722011996	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722011997	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
743722011998	active site
743722011999	metal binding site [ion binding]; metal-binding site
743722012000	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012001	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012002	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722012003	C factor cell-cell signaling protein; Provisional; Region: PRK09009
743722012004	NAD(P) binding site [chemical binding]; other site
743722012005	active site
743722012006	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722012007	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722012008	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722012009	NIPSNAP; Region: NIPSNAP; pfam07978
743722012010	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722012011	short chain dehydrogenase; Provisional; Region: PRK06523
743722012012	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722012013	NAD(P) binding site [chemical binding]; other site
743722012014	active site
743722012015	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012016	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722012017	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
743722012018	putative hydrophobic ligand binding site [chemical binding]; other site
743722012019	Predicted amidohydrolase [General function prediction only]; Region: COG0388
743722012020	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
743722012021	active site
743722012022	catalytic triad [active]
743722012023	dimer interface [polypeptide binding]; other site
743722012024	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
743722012025	active site
743722012026	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722012027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
743722012028	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
743722012029	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
743722012030	active site
743722012031	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
743722012032	sugar binding site [chemical binding]; other site
743722012033	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722012034	Sulfatase; Region: Sulfatase; pfam00884
743722012035	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
743722012036	dimerization interface [polypeptide binding]; other site
743722012037	substrate binding site [chemical binding]; other site
743722012038	active site
743722012039	calcium binding site [ion binding]; other site
743722012040	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012041	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012042	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012043	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012044	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722012045	SusD family; Region: SusD; pfam07980
743722012046	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
743722012047	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
743722012048	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
743722012049	Moco binding site; other site
743722012050	metal coordination site [ion binding]; other site
743722012051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012052	Response regulator receiver domain; Region: Response_reg; pfam00072
743722012053	active site
743722012054	phosphorylation site [posttranslational modification]
743722012055	intermolecular recognition site; other site
743722012056	dimerization interface [polypeptide binding]; other site
743722012057	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
743722012058	dimer interface [polypeptide binding]; other site
743722012059	ADP-ribose binding site [chemical binding]; other site
743722012060	active site
743722012061	nudix motif; other site
743722012062	metal binding site [ion binding]; metal-binding site
743722012063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722012064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722012065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012066	active site
743722012067	phosphorylation site [posttranslational modification]
743722012068	intermolecular recognition site; other site
743722012069	dimerization interface [polypeptide binding]; other site
743722012070	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
743722012071	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
743722012072	thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891
743722012073	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722012074	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012075	active site
743722012076	phosphorylation site [posttranslational modification]
743722012077	intermolecular recognition site; other site
743722012078	dimerization interface [polypeptide binding]; other site
743722012079	LytTr DNA-binding domain; Region: LytTR; smart00850
743722012080	Histidine kinase; Region: His_kinase; pfam06580
743722012081	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722012082	DNA-binding site [nucleotide binding]; DNA binding site
743722012083	RNA-binding motif; other site
743722012084	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
743722012085	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
743722012086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012087	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
743722012088	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722012089	DNA binding residues [nucleotide binding]
743722012090	Cold shock proteins [Transcription]; Region: CspC; COG1278
743722012091	RNA binding site [nucleotide binding]; other site
743722012092	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
743722012093	Fatty acid desaturase; Region: FA_desaturase; pfam00487
743722012094	Di-iron ligands [ion binding]; other site
743722012095	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
743722012096	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
743722012097	putative di-iron ligands [ion binding]; other site
743722012098	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
743722012099	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
743722012100	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
743722012101	Chloramphenicol acetyltransferase; Region: CAT; cl02008
743722012102	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012103	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012104	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
743722012105	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
743722012106	Histidine kinase; Region: His_kinase; pfam06580
743722012107	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722012108	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722012109	catalytic residues [active]
743722012110	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722012111	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012112	active site
743722012113	phosphorylation site [posttranslational modification]
743722012114	intermolecular recognition site; other site
743722012115	dimerization interface [polypeptide binding]; other site
743722012116	LytTr DNA-binding domain; Region: LytTR; smart00850
743722012117	DinB family; Region: DinB; cl17821
743722012118	DinB superfamily; Region: DinB_2; pfam12867
743722012119	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
743722012120	classical (c) SDRs; Region: SDR_c; cd05233
743722012121	NAD(P) binding site [chemical binding]; other site
743722012122	active site
743722012123	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
743722012124	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
743722012125	putative metal binding site [ion binding]; other site
743722012126	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
743722012127	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
743722012128	dimer interface [polypeptide binding]; other site
743722012129	substrate binding site [chemical binding]; other site
743722012130	ATP binding site [chemical binding]; other site
743722012131	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722012132	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722012133	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722012134	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
743722012135	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
743722012136	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722012137	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
743722012138	dimer interface [polypeptide binding]; other site
743722012139	Response regulator receiver domain; Region: Response_reg; pfam00072
743722012140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012141	active site
743722012142	phosphorylation site [posttranslational modification]
743722012143	intermolecular recognition site; other site
743722012144	dimerization interface [polypeptide binding]; other site
743722012145	PAS domain; Region: PAS_9; pfam13426
743722012146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722012147	Histidine kinase; Region: HisKA_3; pfam07730
743722012148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012149	ATP binding site [chemical binding]; other site
743722012150	Mg2+ binding site [ion binding]; other site
743722012151	G-X-G motif; other site
743722012152	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722012153	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722012154	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
743722012155	non-specific DNA binding site [nucleotide binding]; other site
743722012156	salt bridge; other site
743722012157	sequence-specific DNA binding site [nucleotide binding]; other site
743722012158	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
743722012159	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
743722012160	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
743722012161	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012162	YCII-related domain; Region: YCII; cl00999
743722012163	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
743722012164	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
743722012165	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
743722012166	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722012167	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012168	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012169	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
743722012170	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722012171	S-adenosylmethionine binding site [chemical binding]; other site
743722012172	FOG: CBS domain [General function prediction only]; Region: COG0517
743722012173	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
743722012174	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
743722012175	putative catalytic site [active]
743722012176	putative phosphate binding site [ion binding]; other site
743722012177	active site
743722012178	metal binding site A [ion binding]; metal-binding site
743722012179	DNA binding site [nucleotide binding]
743722012180	putative AP binding site [nucleotide binding]; other site
743722012181	putative metal binding site B [ion binding]; other site
743722012182	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
743722012183	dimer interface [polypeptide binding]; other site
743722012184	catalytic triad [active]
743722012185	peroxidatic and resolving cysteines [active]
743722012186	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722012187	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722012188	ligand binding site [chemical binding]; other site
743722012189	flexible hinge region; other site
743722012190	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012191	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012192	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722012193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012194	ATP binding site [chemical binding]; other site
743722012195	Mg2+ binding site [ion binding]; other site
743722012196	G-X-G motif; other site
743722012197	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
743722012198	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
743722012199	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
743722012200	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
743722012201	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
743722012202	Walker A/P-loop; other site
743722012203	ATP binding site [chemical binding]; other site
743722012204	Q-loop/lid; other site
743722012205	ABC transporter signature motif; other site
743722012206	Walker B; other site
743722012207	D-loop; other site
743722012208	H-loop/switch region; other site
743722012209	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
743722012210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722012211	dimer interface [polypeptide binding]; other site
743722012212	conserved gate region; other site
743722012213	putative PBP binding loops; other site
743722012214	ABC-ATPase subunit interface; other site
743722012215	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
743722012216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722012217	dimer interface [polypeptide binding]; other site
743722012218	conserved gate region; other site
743722012219	putative PBP binding loops; other site
743722012220	ABC-ATPase subunit interface; other site
743722012221	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
743722012222	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012223	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722012224	putative DNA binding site [nucleotide binding]; other site
743722012225	dimerization interface [polypeptide binding]; other site
743722012226	putative Zn2+ binding site [ion binding]; other site
743722012227	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
743722012228	non-specific DNA binding site [nucleotide binding]; other site
743722012229	salt bridge; other site
743722012230	sequence-specific DNA binding site [nucleotide binding]; other site
743722012231	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
743722012232	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
743722012233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722012234	dimer interface [polypeptide binding]; other site
743722012235	conserved gate region; other site
743722012236	ABC-ATPase subunit interface; other site
743722012237	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
743722012238	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
743722012239	Walker A/P-loop; other site
743722012240	ATP binding site [chemical binding]; other site
743722012241	Q-loop/lid; other site
743722012242	ABC transporter signature motif; other site
743722012243	Walker B; other site
743722012244	D-loop; other site
743722012245	H-loop/switch region; other site
743722012246	NIL domain; Region: NIL; pfam09383
743722012247	Beta-lactamase; Region: Beta-lactamase; pfam00144
743722012248	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
743722012249	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
743722012250	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
743722012251	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
743722012252	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722012253	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
743722012254	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722012255	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012256	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012257	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012258	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012259	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
743722012260	dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361
743722012261	DAK2 domain; Region: Dak2; pfam02734
743722012262	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
743722012263	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722012264	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
743722012265	Zn binding site [ion binding]; other site
743722012266	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743722012267	active site
743722012268	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
743722012269	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
743722012270	NADP binding site [chemical binding]; other site
743722012271	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722012272	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
743722012273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722012274	H+ Antiporter protein; Region: 2A0121; TIGR00900
743722012275	putative substrate translocation pore; other site
743722012276	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
743722012277	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
743722012278	N- and C-terminal domain interface [polypeptide binding]; other site
743722012279	active site
743722012280	catalytic site [active]
743722012281	metal binding site [ion binding]; metal-binding site
743722012282	carbohydrate binding site [chemical binding]; other site
743722012283	ATP binding site [chemical binding]; other site
743722012284	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722012285	Sulfatase; Region: Sulfatase; pfam00884
743722012286	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
743722012287	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
743722012288	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
743722012289	putative catalytic site [active]
743722012290	putative metal binding site [ion binding]; other site
743722012291	putative phosphate binding site [ion binding]; other site
743722012292	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722012293	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722012294	SnoaL-like domain; Region: SnoaL_3; pfam13474
743722012295	SnoaL-like domain; Region: SnoaL_2; pfam12680
743722012296	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
743722012297	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012298	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
743722012299	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
743722012300	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722012301	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722012302	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722012303	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
743722012304	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
743722012305	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722012306	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
743722012307	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
743722012308	oligomerisation interface [polypeptide binding]; other site
743722012309	mobile loop; other site
743722012310	roof hairpin; other site
743722012311	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
743722012312	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
743722012313	Integral membrane protein DUF92; Region: DUF92; pfam01940
743722012314	YceI-like domain; Region: YceI; pfam04264
743722012315	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
743722012316	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
743722012317	active site
743722012318	intersubunit interface [polypeptide binding]; other site
743722012319	catalytic residue [active]
743722012320	galactonate dehydratase; Provisional; Region: PRK14017
743722012321	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
743722012322	putative active site pocket [active]
743722012323	putative metal binding site [ion binding]; other site
743722012324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722012325	D-galactonate transporter; Region: 2A0114; TIGR00893
743722012326	putative substrate translocation pore; other site
743722012327	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
743722012328	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
743722012329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722012330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722012331	putative substrate translocation pore; other site
743722012332	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
743722012333	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
743722012334	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743722012335	Class I aldolases; Region: Aldolase_Class_I; cl17187
743722012336	catalytic residue [active]
743722012337	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
743722012338	catalytic site [active]
743722012339	BNR repeat-like domain; Region: BNR_2; pfam13088
743722012340	Asp-box motif; other site
743722012341	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
743722012342	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
743722012343	inhibitor site; inhibition site
743722012344	active site
743722012345	dimer interface [polypeptide binding]; other site
743722012346	catalytic residue [active]
743722012347	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
743722012348	catalytic site [active]
743722012349	BNR repeat-like domain; Region: BNR_2; pfam13088
743722012350	Asp-box motif; other site
743722012351	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743722012352	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722012353	DNA-binding site [nucleotide binding]; DNA binding site
743722012354	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722012355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722012356	homodimer interface [polypeptide binding]; other site
743722012357	catalytic residue [active]
743722012358	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
743722012359	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
743722012360	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
743722012361	short chain dehydrogenase; Provisional; Region: PRK06123
743722012362	classical (c) SDRs; Region: SDR_c; cd05233
743722012363	NAD(P) binding site [chemical binding]; other site
743722012364	active site
743722012365	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012366	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743722012367	putative hydrophobic ligand binding site [chemical binding]; other site
743722012368	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722012369	dimerization interface [polypeptide binding]; other site
743722012370	putative DNA binding site [nucleotide binding]; other site
743722012371	putative Zn2+ binding site [ion binding]; other site
743722012372	Helix-turn-helix domain; Region: HTH_17; pfam12728
743722012373	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
743722012374	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
743722012375	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
743722012376	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
743722012377	Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459
743722012378	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
743722012379	RteC protein; Region: RteC; pfam09357
743722012380	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
743722012381	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
743722012382	active site
743722012383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722012384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722012385	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
743722012386	metal binding site 2 [ion binding]; metal-binding site
743722012387	putative DNA binding helix; other site
743722012388	metal binding site 1 [ion binding]; metal-binding site
743722012389	dimer interface [polypeptide binding]; other site
743722012390	structural Zn2+ binding site [ion binding]; other site
743722012391	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
743722012392	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
743722012393	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
743722012394	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722012395	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012396	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012397	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722012398	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722012399	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012400	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722012401	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722012402	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722012403	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743722012404	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722012405	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012406	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722012407	Domain of unknown function (DUF932); Region: DUF932; pfam06067
743722012408	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
743722012409	dimer interface [polypeptide binding]; other site
743722012410	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
743722012411	ssDNA binding site [nucleotide binding]; other site
743722012412	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743722012413	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
743722012414	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
743722012415	catalytic residues [active]
743722012416	catalytic nucleophile [active]
743722012417	Recombinase; Region: Recombinase; pfam07508
743722012418	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
743722012419	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
743722012420	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
743722012421	catalytic residues [active]
743722012422	catalytic nucleophile [active]
743722012423	Recombinase; Region: Recombinase; pfam07508
743722012424	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
743722012425	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
743722012426	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722012427	Protein export membrane protein; Region: SecD_SecF; cl14618
743722012428	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722012429	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722012430	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722012431	Outer membrane efflux protein; Region: OEP; pfam02321
743722012432	Outer membrane efflux protein; Region: OEP; pfam02321
743722012433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722012434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722012435	WHG domain; Region: WHG; pfam13305
743722012436	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
743722012437	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
743722012438	active site
743722012439	Zn binding site [ion binding]; other site
743722012440	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
743722012441	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
743722012442	dimer interface [polypeptide binding]; other site
743722012443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722012444	catalytic residue [active]
743722012445	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
743722012446	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722012447	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722012448	Transposase [DNA replication, recombination, and repair]; Region: COG5433
743722012449	Histidine kinase; Region: His_kinase; pfam06580
743722012450	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722012451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012452	active site
743722012453	phosphorylation site [posttranslational modification]
743722012454	intermolecular recognition site; other site
743722012455	dimerization interface [polypeptide binding]; other site
743722012456	LytTr DNA-binding domain; Region: LytTR; smart00850
743722012457	Phytase; Region: Phytase; cl17685
743722012458	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722012459	TPR motif; other site
743722012460	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722012461	binding surface
743722012462	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722012463	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722012464	binding surface
743722012465	TPR motif; other site
743722012466	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722012467	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012468	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
743722012469	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012470	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012471	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722012472	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722012473	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
743722012474	active site residue [active]
743722012475	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
743722012476	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
743722012477	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
743722012478	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
743722012479	homodimer interface [polypeptide binding]; other site
743722012480	substrate-cofactor binding pocket; other site
743722012481	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722012482	catalytic residue [active]
743722012483	prolyl-tRNA synthetase; Provisional; Region: PRK08661
743722012484	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
743722012485	dimer interface [polypeptide binding]; other site
743722012486	motif 1; other site
743722012487	active site
743722012488	motif 2; other site
743722012489	motif 3; other site
743722012490	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
743722012491	anticodon binding site; other site
743722012492	zinc-binding site [ion binding]; other site
743722012493	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
743722012494	Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891
743722012495	putative hydrophobic ligand binding site [chemical binding]; other site
743722012496	CLM binding site; other site
743722012497	L1 loop; other site
743722012498	DNA binding site [nucleotide binding]
743722012499	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722012500	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
743722012501	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012502	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722012503	DNA binding residues [nucleotide binding]
743722012504	YceI-like domain; Region: YceI; pfam04264
743722012505	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
743722012506	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
743722012507	dimerization interface [polypeptide binding]; other site
743722012508	DPS ferroxidase diiron center [ion binding]; other site
743722012509	ion pore; other site
743722012510	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
743722012511	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
743722012512	dimer interface [polypeptide binding]; other site
743722012513	active site residues [active]
743722012514	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
743722012515	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743722012516	active site
743722012517	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
743722012518	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
743722012519	four helix bundle protein; Region: TIGR02436
743722012520	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
743722012521	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
743722012522	MutS domain III; Region: MutS_III; pfam05192
743722012523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722012524	Walker A/P-loop; other site
743722012525	ATP binding site [chemical binding]; other site
743722012526	Q-loop/lid; other site
743722012527	ABC transporter signature motif; other site
743722012528	Walker B; other site
743722012529	D-loop; other site
743722012530	H-loop/switch region; other site
743722012531	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
743722012532	Smr domain; Region: Smr; pfam01713
743722012533	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
743722012534	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
743722012535	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743722012536	catalytic residue [active]
743722012537	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
743722012538	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722012539	Coenzyme A binding pocket [chemical binding]; other site
743722012540	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
743722012541	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
743722012542	Pyrococcus aspartate kinase subunit, putative; Region: AspKin_pair; TIGR02078
743722012543	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
743722012544	nucleotide binding site [chemical binding]; other site
743722012545	substrate binding site [chemical binding]; other site
743722012546	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
743722012547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722012548	S-adenosylmethionine binding site [chemical binding]; other site
743722012549	Protein of unknown function (DUF502); Region: DUF502; pfam04367
743722012550	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
743722012551	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
743722012552	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
743722012553	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
743722012554	active site
743722012555	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
743722012556	dimer interface [polypeptide binding]; other site
743722012557	substrate binding site [chemical binding]; other site
743722012558	catalytic residues [active]
743722012559	RecX family; Region: RecX; pfam02631
743722012560	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722012561	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722012562	ligand binding site [chemical binding]; other site
743722012563	flexible hinge region; other site
743722012564	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
743722012565	Uncharacterized conserved protein [Function unknown]; Region: COG2128
743722012566	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
743722012567	DNA-binding site [nucleotide binding]; DNA binding site
743722012568	RNA-binding motif; other site
743722012569	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
743722012570	putative metal binding site [ion binding]; other site
743722012571	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
743722012572	Uncharacterized conserved protein [Function unknown]; Region: COG2128
743722012573	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
743722012574	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
743722012575	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722012576	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722012577	DNA binding residues [nucleotide binding]
743722012578	FecR protein; Region: FecR; pfam04773
743722012579	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722012580	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012581	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012582	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722012583	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722012584	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012585	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012586	SusD family; Region: SusD; pfam07980
743722012587	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
743722012588	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
743722012589	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722012590	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
743722012591	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
743722012592	NAD binding site [chemical binding]; other site
743722012593	catalytic Zn binding site [ion binding]; other site
743722012594	structural Zn binding site [ion binding]; other site
743722012595	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
743722012596	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722012597	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012598	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722012599	DNA binding residues [nucleotide binding]
743722012600	FecR protein; Region: FecR; pfam04773
743722012601	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722012602	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012603	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012604	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012605	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012606	SusD family; Region: SusD; pfam07980
743722012607	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722012608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722012609	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
743722012610	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
743722012611	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
743722012612	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
743722012613	DNA-binding site [nucleotide binding]; DNA binding site
743722012614	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722012615	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722012616	homodimer interface [polypeptide binding]; other site
743722012617	catalytic residue [active]
743722012618	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
743722012619	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
743722012620	acyl-activating enzyme (AAE) consensus motif; other site
743722012621	AMP binding site [chemical binding]; other site
743722012622	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
743722012623	thioester reductase domain; Region: Thioester-redct; TIGR01746
743722012624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722012625	NAD(P) binding site [chemical binding]; other site
743722012626	active site
743722012627	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
743722012628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012629	active site
743722012630	phosphorylation site [posttranslational modification]
743722012631	intermolecular recognition site; other site
743722012632	dimerization interface [polypeptide binding]; other site
743722012633	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
743722012634	Moco binding site; other site
743722012635	metal coordination site [ion binding]; other site
743722012636	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
743722012637	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012638	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012639	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012640	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012641	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722012642	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012643	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722012644	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722012645	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
743722012646	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
743722012647	Predicted deacylase [General function prediction only]; Region: COG3608
743722012648	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
743722012649	active site
743722012650	Zn binding site [ion binding]; other site
743722012651	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
743722012652	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
743722012653	GDP-binding site [chemical binding]; other site
743722012654	ACT binding site; other site
743722012655	IMP binding site; other site
743722012656	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722012657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722012658	ligand binding site [chemical binding]; other site
743722012659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012660	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722012661	active site
743722012662	phosphorylation site [posttranslational modification]
743722012663	intermolecular recognition site; other site
743722012664	dimerization interface [polypeptide binding]; other site
743722012665	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
743722012666	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
743722012667	active site
743722012668	metal binding site [ion binding]; metal-binding site
743722012669	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
743722012670	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
743722012671	Walker A/P-loop; other site
743722012672	ATP binding site [chemical binding]; other site
743722012673	Q-loop/lid; other site
743722012674	ABC transporter signature motif; other site
743722012675	Walker B; other site
743722012676	D-loop; other site
743722012677	H-loop/switch region; other site
743722012678	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
743722012679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722012680	dimer interface [polypeptide binding]; other site
743722012681	conserved gate region; other site
743722012682	putative PBP binding loops; other site
743722012683	ABC-ATPase subunit interface; other site
743722012684	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
743722012685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
743722012686	dimer interface [polypeptide binding]; other site
743722012687	conserved gate region; other site
743722012688	putative PBP binding loops; other site
743722012689	ABC-ATPase subunit interface; other site
743722012690	PBP superfamily domain; Region: PBP_like_2; cl17296
743722012691	Response regulator receiver domain; Region: Response_reg; pfam00072
743722012692	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012693	active site
743722012694	phosphorylation site [posttranslational modification]
743722012695	intermolecular recognition site; other site
743722012696	dimerization interface [polypeptide binding]; other site
743722012697	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
743722012698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722012699	heme pocket [chemical binding]; other site
743722012700	putative active site [active]
743722012701	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722012702	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722012703	putative active site [active]
743722012704	heme pocket [chemical binding]; other site
743722012705	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722012706	dimer interface [polypeptide binding]; other site
743722012707	phosphorylation site [posttranslational modification]
743722012708	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012709	ATP binding site [chemical binding]; other site
743722012710	Mg2+ binding site [ion binding]; other site
743722012711	G-X-G motif; other site
743722012712	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722012713	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
743722012714	DNA binding residues [nucleotide binding]
743722012715	dimerization interface [polypeptide binding]; other site
743722012716	amidase; Provisional; Region: PRK11910
743722012717	Histidine kinase; Region: His_kinase; pfam06580
743722012718	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
743722012719	ATP binding site [chemical binding]; other site
743722012720	Mg2+ binding site [ion binding]; other site
743722012721	G-X-G motif; other site
743722012722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012723	Response regulator receiver domain; Region: Response_reg; pfam00072
743722012724	active site
743722012725	phosphorylation site [posttranslational modification]
743722012726	intermolecular recognition site; other site
743722012727	dimerization interface [polypeptide binding]; other site
743722012728	LytTr DNA-binding domain; Region: LytTR; smart00850
743722012729	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722012730	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722012731	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012732	SusD family; Region: SusD; pfam07980
743722012733	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722012734	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012735	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012736	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012737	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722012738	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
743722012739	Sulfatase; Region: Sulfatase; cl17466
743722012740	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
743722012741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722012742	Coenzyme A binding pocket [chemical binding]; other site
743722012743	Predicted membrane protein [Function unknown]; Region: COG3059
743722012744	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012745	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012746	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
743722012747	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
743722012748	catalytic loop [active]
743722012749	iron binding site [ion binding]; other site
743722012750	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
743722012751	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
743722012752	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722012753	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
743722012754	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
743722012755	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722012756	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722012757	catalytic residues [active]
743722012758	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722012759	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722012760	catalytic residues [active]
743722012761	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012762	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012763	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012764	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012765	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012766	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012767	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722012768	Sulfatase; Region: Sulfatase; pfam00884
743722012769	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012770	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012771	short chain dehydrogenase; Provisional; Region: PRK06180
743722012772	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722012773	NADP binding site [chemical binding]; other site
743722012774	active site
743722012775	steroid binding site; other site
743722012776	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012778	maltose O-acetyltransferase; Provisional; Region: PRK10092
743722012779	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
743722012780	active site
743722012781	substrate binding site [chemical binding]; other site
743722012782	trimer interface [polypeptide binding]; other site
743722012783	CoA binding site [chemical binding]; other site
743722012784	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
743722012785	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
743722012786	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722012787	NAD(P) binding site [chemical binding]; other site
743722012788	active site
743722012789	GH3 auxin-responsive promoter; Region: GH3; pfam03321
743722012790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722012791	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722012792	active site
743722012793	catalytic tetrad [active]
743722012794	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722012795	FtsX-like permease family; Region: FtsX; pfam02687
743722012796	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722012797	FtsX-like permease family; Region: FtsX; pfam02687
743722012798	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743722012799	putative hydrophobic ligand binding site [chemical binding]; other site
743722012800	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
743722012801	metal-binding site [ion binding]
743722012802	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012803	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012804	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
743722012805	arsenical-resistance protein; Region: acr3; TIGR00832
743722012806	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
743722012807	Low molecular weight phosphatase family; Region: LMWPc; cd00115
743722012808	active site
743722012809	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722012810	dimerization interface [polypeptide binding]; other site
743722012811	putative DNA binding site [nucleotide binding]; other site
743722012812	putative Zn2+ binding site [ion binding]; other site
743722012813	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
743722012814	substrate binding pocket [chemical binding]; other site
743722012815	substrate-Mg2+ binding site; other site
743722012816	aspartate-rich region 1; other site
743722012817	aspartate-rich region 2; other site
743722012818	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
743722012819	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
743722012820	substrate binding [chemical binding]; other site
743722012821	active site
743722012822	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
743722012823	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
743722012824	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
743722012825	putative substrate binding site [chemical binding]; other site
743722012826	putative ATP binding site [chemical binding]; other site
743722012827	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
743722012828	catalytic residues [active]
743722012829	probable cinnamyl alcohol dehydrogenase; Region: PLN02586
743722012830	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
743722012831	putative NAD(P) binding site [chemical binding]; other site
743722012832	putative substrate binding site [chemical binding]; other site
743722012833	catalytic Zn binding site [ion binding]; other site
743722012834	structural Zn binding site [ion binding]; other site
743722012835	dimer interface [polypeptide binding]; other site
743722012836	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722012837	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012838	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012839	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722012840	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
743722012841	dimer interface [polypeptide binding]; other site
743722012842	FMN binding site [chemical binding]; other site
743722012843	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
743722012844	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722012845	putative NAD(P) binding site [chemical binding]; other site
743722012846	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012848	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
743722012849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722012850	putative substrate translocation pore; other site
743722012851	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
743722012852	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
743722012853	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
743722012854	active site
743722012855	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012856	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012857	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012858	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012859	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012860	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722012861	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722012862	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722012863	DNA binding site [nucleotide binding]
743722012864	domain linker motif; other site
743722012865	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722012866	ligand binding site [chemical binding]; other site
743722012867	dimerization interface [polypeptide binding]; other site
743722012868	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
743722012869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722012870	dimer interface [polypeptide binding]; other site
743722012871	phosphorylation site [posttranslational modification]
743722012872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012873	ATP binding site [chemical binding]; other site
743722012874	Mg2+ binding site [ion binding]; other site
743722012875	G-X-G motif; other site
743722012876	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
743722012877	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
743722012878	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722012879	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722012880	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722012881	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012882	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722012883	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722012884	FecR protein; Region: FecR; pfam04773
743722012885	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722012886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722012888	DNA binding residues [nucleotide binding]
743722012889	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
743722012890	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
743722012891	oligomeric interface; other site
743722012892	putative active site [active]
743722012893	homodimer interface [polypeptide binding]; other site
743722012894	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
743722012895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722012896	Coenzyme A binding pocket [chemical binding]; other site
743722012897	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722012898	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
743722012899	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722012900	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722012901	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722012902	Histidine kinase; Region: His_kinase; pfam06580
743722012903	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722012904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012905	active site
743722012906	phosphorylation site [posttranslational modification]
743722012907	intermolecular recognition site; other site
743722012908	dimerization interface [polypeptide binding]; other site
743722012909	LytTr DNA-binding domain; Region: LytTR; smart00850
743722012910	Fic family protein [Function unknown]; Region: COG3177
743722012911	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
743722012912	Fic/DOC family; Region: Fic; pfam02661
743722012913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722012914	TPR repeat; Region: TPR_11; pfam13414
743722012915	binding surface
743722012916	TPR motif; other site
743722012917	Histidine kinase; Region: HisKA_3; pfam07730
743722012918	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012919	ATP binding site [chemical binding]; other site
743722012920	Mg2+ binding site [ion binding]; other site
743722012921	G-X-G motif; other site
743722012922	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012923	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722012924	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722012925	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722012926	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012928	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
743722012929	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
743722012930	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
743722012931	CAAX protease self-immunity; Region: Abi; pfam02517
743722012932	Protein of unknown function (DUF3626); Region: DUF3626; pfam12294
743722012933	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
743722012934	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
743722012935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315
743722012936	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
743722012937	Putative cyclase; Region: Cyclase; pfam04199
743722012938	acyltransferase PapA5; Provisional; Region: PRK09294
743722012939	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722012940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722012941	active site
743722012942	phosphorylation site [posttranslational modification]
743722012943	intermolecular recognition site; other site
743722012944	dimerization interface [polypeptide binding]; other site
743722012945	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722012946	DNA binding residues [nucleotide binding]
743722012947	dimerization interface [polypeptide binding]; other site
743722012948	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722012949	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722012950	Histidine kinase; Region: HisKA_3; pfam07730
743722012951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722012952	ATP binding site [chemical binding]; other site
743722012953	Mg2+ binding site [ion binding]; other site
743722012954	G-X-G motif; other site
743722012955	Protein of unknown function DUF260; Region: DUF260; pfam03195
743722012956	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
743722012957	protein-splicing catalytic site; other site
743722012958	thioester formation/cholesterol transfer; other site
743722012959	Pretoxin HINT domain; Region: PT-HINT; pfam07591
743722012960	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
743722012961	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
743722012962	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
743722012963	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522; cl01406
743722012964	Protein of unknown function (DUF1305); Region: DUF1305; cl01404
743722012965	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
743722012966	Protein of unknown function (DUF877); Region: DUF877; pfam05943
743722012967	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
743722012968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722012969	Walker A motif; other site
743722012970	ATP binding site [chemical binding]; other site
743722012971	Walker B motif; other site
743722012972	arginine finger; other site
743722012973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722012974	Walker A motif; other site
743722012975	ATP binding site [chemical binding]; other site
743722012976	Walker B motif; other site
743722012977	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
743722012978	PKD domain; Region: PKD; pfam00801
743722012979	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012980	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012981	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722012982	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722012983	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
743722012984	Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell division and chromosome partitioning]; Region: NIP100; COG5244
743722012985	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
743722012986	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
743722012987	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722012988	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722012989	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
743722012990	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
743722012991	FMN binding site [chemical binding]; other site
743722012992	active site
743722012993	substrate binding site [chemical binding]; other site
743722012994	catalytic residue [active]
743722012995	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
743722012996	active site
743722012997	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722012998	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722012999	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722013000	DNA binding residues [nucleotide binding]
743722013001	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722013002	FecR protein; Region: FecR; pfam04773
743722013003	Secretin and TonB N terminus short domain; Region: STN; pfam07660
743722013004	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013005	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013006	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722013007	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722013008	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722013009	SusD family; Region: SusD; pfam07980
743722013010	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
743722013011	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
743722013012	NADP binding site [chemical binding]; other site
743722013013	putative substrate binding site [chemical binding]; other site
743722013014	active site
743722013015	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
743722013016	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
743722013017	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722013018	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722013019	Outer membrane efflux protein; Region: OEP; pfam02321
743722013020	Outer membrane efflux protein; Region: OEP; pfam02321
743722013021	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013022	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013023	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
743722013024	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
743722013025	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722013026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013027	short chain dehydrogenase; Provisional; Region: PRK06197
743722013028	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
743722013029	putative NAD(P) binding site [chemical binding]; other site
743722013030	active site
743722013031	YCII-related domain; Region: YCII; cl00999
743722013032	Uncharacterized conserved protein [Function unknown]; Region: COG2128
743722013033	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
743722013034	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
743722013035	active site 2 [active]
743722013036	active site 1 [active]
743722013037	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
743722013038	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
743722013039	putative Iron-sulfur protein interface [polypeptide binding]; other site
743722013040	proximal heme binding site [chemical binding]; other site
743722013041	distal heme binding site [chemical binding]; other site
743722013042	putative dimer interface [polypeptide binding]; other site
743722013043	YCII-related domain; Region: YCII; cl00999
743722013044	YCII-related domain; Region: YCII; cl00999
743722013045	Pirin; Region: Pirin; pfam02678
743722013046	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
743722013047	NADH(P)-binding; Region: NAD_binding_10; pfam13460
743722013048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722013049	NAD(P) binding site [chemical binding]; other site
743722013050	active site
743722013051	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
743722013052	nudix motif; other site
743722013053	GAF domain; Region: GAF_3; pfam13492
743722013054	GAF domain; Region: GAF_2; pfam13185
743722013055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013056	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
743722013057	Walker A motif; other site
743722013058	ATP binding site [chemical binding]; other site
743722013059	Walker B motif; other site
743722013060	arginine finger; other site
743722013061	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
743722013062	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722013063	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
743722013064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722013065	DNA binding residues [nucleotide binding]
743722013066	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
743722013067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013068	active site
743722013069	phosphorylation site [posttranslational modification]
743722013070	intermolecular recognition site; other site
743722013071	dimerization interface [polypeptide binding]; other site
743722013072	LytTr DNA-binding domain; Region: LytTR; smart00850
743722013073	Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604
743722013074	GAF domain; Region: GAF_3; pfam13492
743722013075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013076	Walker A motif; other site
743722013077	ATP binding site [chemical binding]; other site
743722013078	Walker B motif; other site
743722013079	arginine finger; other site
743722013080	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
743722013081	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
743722013082	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
743722013083	tetramer interface [polypeptide binding]; other site
743722013084	heme binding pocket [chemical binding]; other site
743722013085	NADPH binding site [chemical binding]; other site
743722013086	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
743722013087	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
743722013088	substrate binding pocket [chemical binding]; other site
743722013089	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
743722013090	GAF domain; Region: GAF; cl17456
743722013091	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013092	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
743722013093	Walker A motif; other site
743722013094	ATP binding site [chemical binding]; other site
743722013095	Walker B motif; other site
743722013096	arginine finger; other site
743722013097	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
743722013098	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722013099	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722013100	dimerization interface [polypeptide binding]; other site
743722013101	putative DNA binding site [nucleotide binding]; other site
743722013102	putative Zn2+ binding site [ion binding]; other site
743722013103	Haem-binding domain; Region: Haem_bd; pfam14376
743722013104	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013105	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013106	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722013107	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
743722013108	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
743722013109	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
743722013110	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
743722013111	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
743722013112	HlyD family secretion protein; Region: HlyD_3; pfam13437
743722013113	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722013114	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722013115	WHG domain; Region: WHG; pfam13305
743722013116	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
743722013117	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013118	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013119	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722013120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013121	active site
743722013122	phosphorylation site [posttranslational modification]
743722013123	intermolecular recognition site; other site
743722013124	dimerization interface [polypeptide binding]; other site
743722013125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
743722013126	DNA binding residues [nucleotide binding]
743722013127	dimerization interface [polypeptide binding]; other site
743722013128	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
743722013129	classical (c) SDRs; Region: SDR_c; cd05233
743722013130	NAD(P) binding site [chemical binding]; other site
743722013131	active site
743722013132	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
743722013133	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
743722013134	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
743722013135	DNA binding residues [nucleotide binding]
743722013136	LytTr DNA-binding domain; Region: LytTR; smart00850
743722013137	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
743722013138	putative acyl-acceptor binding pocket; other site
743722013139	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
743722013140	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
743722013141	ligand binding site [chemical binding]; other site
743722013142	flexible hinge region; other site
743722013143	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013144	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013145	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013146	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013147	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722013148	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722013149	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
743722013150	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
743722013151	catalytic residues [active]
743722013152	Protein of unknown function (DUF3738); Region: DUF3738; cl11887
743722013153	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
743722013154	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
743722013155	PLD-like domain; Region: PLDc_2; pfam13091
743722013156	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
743722013157	putative homodimer interface [polypeptide binding]; other site
743722013158	putative active site [active]
743722013159	catalytic site [active]
743722013160	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06591
743722013161	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
743722013162	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
743722013163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
743722013164	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
743722013165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
743722013166	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
743722013167	Cloacin immunity protein; Region: Cloacin_immun; pfam03513
743722013168	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890
743722013169	EVE domain; Region: EVE; cl00728
743722013170	Uncharacterized conserved protein [Function unknown]; Region: COG4933
743722013171	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722013172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013173	Walker A motif; other site
743722013174	ATP binding site [chemical binding]; other site
743722013175	Walker B motif; other site
743722013176	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
743722013177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722013178	Integrase core domain; Region: rve; pfam00665
743722013179	TIR domain; Region: TIR_2; pfam13676
743722013180	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
743722013181	Catalytic domain of Protein Kinases; Region: PKc; cd00180
743722013182	active site
743722013183	ATP binding site [chemical binding]; other site
743722013184	substrate binding site [chemical binding]; other site
743722013185	activation loop (A-loop); other site
743722013186	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
743722013187	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
743722013188	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
743722013189	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013190	Walker A motif; other site
743722013191	ATP binding site [chemical binding]; other site
743722013192	Walker B motif; other site
743722013193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722013194	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
743722013195	DNA-binding interface [nucleotide binding]; DNA binding site
743722013196	Integrase core domain; Region: rve; pfam00665
743722013197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
743722013198	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
743722013199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013200	active site
743722013201	phosphorylation site [posttranslational modification]
743722013202	intermolecular recognition site; other site
743722013203	dimerization interface [polypeptide binding]; other site
743722013204	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722013205	ATP binding site [chemical binding]; other site
743722013206	Mg2+ binding site [ion binding]; other site
743722013207	G-X-G motif; other site
743722013208	antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034
743722013209	antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032
743722013210	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
743722013211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722013212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722013213	Transglutaminase-like superfamily; Region: Transglut_core; cl17362
743722013214	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722013215	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722013216	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722013217	ORF6N domain; Region: ORF6N; pfam10543
743722013218	MG2 domain; Region: A2M_N; pfam01835
743722013219	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722013220	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
743722013221	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
743722013222	Domain interface; other site
743722013223	Active site tetrad [active]
743722013224	Peptide binding site; other site
743722013225	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
743722013226	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
743722013227	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
743722013228	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
743722013229	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
743722013230	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722013231	FtsX-like permease family; Region: FtsX; pfam02687
743722013232	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
743722013233	FtsX-like permease family; Region: FtsX; pfam02687
743722013234	Transposase; Region: DEDD_Tnp_IS110; pfam01548
743722013235	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
743722013236	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
743722013237	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
743722013238	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013239	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013240	short chain dehydrogenase; Provisional; Region: PRK08263
743722013241	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722013242	NADP binding site [chemical binding]; other site
743722013243	active site
743722013244	steroid binding site; other site
743722013245	short chain dehydrogenase; Provisional; Region: PRK08263
743722013246	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
743722013247	NADP binding site [chemical binding]; other site
743722013248	active site
743722013249	steroid binding site; other site
743722013250	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013251	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722013252	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722013253	TAP-like protein; Region: Abhydrolase_4; pfam08386
743722013254	oxidoreductase; Provisional; Region: PRK06196
743722013255	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
743722013256	putative NAD(P) binding site [chemical binding]; other site
743722013257	active site
743722013258	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013259	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013260	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
743722013261	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
743722013262	Coenzyme A binding pocket [chemical binding]; other site
743722013263	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
743722013264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722013265	Walker A/P-loop; other site
743722013266	ATP binding site [chemical binding]; other site
743722013267	Q-loop/lid; other site
743722013268	ABC transporter signature motif; other site
743722013269	Walker B; other site
743722013270	D-loop; other site
743722013271	H-loop/switch region; other site
743722013272	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
743722013273	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
743722013274	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722013275	NAD(P) binding site [chemical binding]; other site
743722013276	active site
743722013277	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013279	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
743722013280	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722013281	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722013282	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722013283	Major Facilitator Superfamily; Region: MFS_1; pfam07690
743722013284	putative substrate translocation pore; other site
743722013285	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013287	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
743722013288	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
743722013289	active site
743722013290	catalytic tetrad [active]
743722013291	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
743722013292	Predicted transcriptional regulators [Transcription]; Region: COG1733
743722013293	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
743722013294	Domain of unknown function (DUF303); Region: DUF303; pfam03629
743722013295	Helix-turn-helix domain; Region: HTH_18; pfam12833
743722013296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013297	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
743722013298	dimer interface [polypeptide binding]; other site
743722013299	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
743722013300	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722013301	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
743722013302	amidohydrolase; Region: amidohydrolases; TIGR01891
743722013303	putative metal binding site [ion binding]; other site
743722013304	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
743722013305	active site
743722013306	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013307	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013308	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013309	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013310	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722013311	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722013312	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
743722013313	FecR protein; Region: FecR; pfam04773
743722013314	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
743722013315	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
743722013316	DNA binding residues [nucleotide binding]
743722013317	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
743722013318	putative ADP-ribose binding site [chemical binding]; other site
743722013319	putative active site [active]
743722013320	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
743722013321	AAA domain; Region: AAA_33; pfam13671
743722013322	AAA domain; Region: AAA_17; pfam13207
743722013323	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
743722013324	dimerization interface [polypeptide binding]; other site
743722013325	putative DNA binding site [nucleotide binding]; other site
743722013326	putative Zn2+ binding site [ion binding]; other site
743722013327	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
743722013328	putative hydrophobic ligand binding site [chemical binding]; other site
743722013329	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
743722013330	putative dimer interface [polypeptide binding]; other site
743722013331	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722013332	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
743722013333	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
743722013334	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
743722013335	short chain dehydrogenase; Provisional; Region: PRK06523
743722013336	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
743722013337	NAD(P) binding site [chemical binding]; other site
743722013338	active site
743722013339	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
743722013340	hypothetical protein; Reviewed; Region: PRK09588
743722013341	WYL domain; Region: WYL; pfam13280
743722013342	AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052
743722013343	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
743722013344	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
743722013345	DinB superfamily; Region: DinB_2; pfam12867
743722013346	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722013347	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
743722013348	active site
743722013349	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
743722013350	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
743722013351	conserved cys residue [active]
743722013352	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013354	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
743722013355	putative hydrophobic ligand binding site [chemical binding]; other site
743722013356	DoxX-like family; Region: DoxX_2; pfam13564
743722013357	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
743722013358	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
743722013359	active site
743722013360	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
743722013361	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
743722013362	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
743722013363	Tetratricopeptide repeat; Region: TPR_16; pfam13432
743722013364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722013365	TPR motif; other site
743722013366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
743722013367	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
743722013368	Membrane transport protein; Region: Mem_trans; cl09117
743722013369	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722013370	Sulfatase; Region: Sulfatase; pfam00884
743722013371	Glycosyl hydrolase family 43; Region: GH43_7; cd08986
743722013372	active site
743722013373	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013374	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013375	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013376	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013377	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722013378	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
743722013379	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722013380	Sulfatase; Region: Sulfatase; pfam00884
743722013381	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
743722013382	Two component regulator propeller; Region: Reg_prop; pfam07494
743722013383	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
743722013384	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
743722013385	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722013386	dimer interface [polypeptide binding]; other site
743722013387	phosphorylation site [posttranslational modification]
743722013388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722013389	ATP binding site [chemical binding]; other site
743722013390	Mg2+ binding site [ion binding]; other site
743722013391	G-X-G motif; other site
743722013392	Response regulator receiver domain; Region: Response_reg; pfam00072
743722013393	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013394	active site
743722013395	phosphorylation site [posttranslational modification]
743722013396	intermolecular recognition site; other site
743722013397	dimerization interface [polypeptide binding]; other site
743722013398	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
743722013399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013400	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
743722013401	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
743722013402	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
743722013403	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722013404	N-terminal plug; other site
743722013405	ligand-binding site [chemical binding]; other site
743722013406	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
743722013407	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
743722013408	Methyltransferase domain; Region: Methyltransf_31; pfam13847
743722013409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722013410	S-adenosylmethionine binding site [chemical binding]; other site
743722013411	RibD C-terminal domain; Region: RibD_C; cl17279
743722013412	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
743722013413	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
743722013414	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
743722013415	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
743722013416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
743722013417	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
743722013418	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
743722013419	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
743722013420	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
743722013421	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
743722013422	hydroperoxidase II; Provisional; Region: katE; PRK11249
743722013423	Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155
743722013424	tetramer interface [polypeptide binding]; other site
743722013425	heme binding pocket [chemical binding]; other site
743722013426	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
743722013427	domain interactions; other site
743722013428	YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909
743722013429	dimerization interface [polypeptide binding]; other site
743722013430	metal binding site [ion binding]; metal-binding site
743722013431	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
743722013432	active site
743722013433	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
743722013434	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
743722013435	putative substrate binding site [chemical binding]; other site
743722013436	active site
743722013437	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
743722013438	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
743722013439	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
743722013440	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013441	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013442	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013443	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722013444	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722013445	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
743722013446	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
743722013447	conserved cys residue [active]
743722013448	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
743722013449	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
743722013450	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
743722013451	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
743722013452	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
743722013453	putative active site [active]
743722013454	putative catalytic site [active]
743722013455	DoxX-like family; Region: DoxX_2; pfam13564
743722013456	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
743722013457	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
743722013458	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
743722013459	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
743722013460	MoaE homodimer interface [polypeptide binding]; other site
743722013461	MoaD interaction [polypeptide binding]; other site
743722013462	active site residues [active]
743722013463	Chromate transporter; Region: Chromate_transp; pfam02417
743722013464	Chromate transporter; Region: Chromate_transp; pfam02417
743722013465	Acyltransferase family; Region: Acyl_transf_3; pfam01757
743722013466	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
743722013467	MarR family; Region: MarR_2; pfam12802
743722013468	DinB superfamily; Region: DinB_2; pfam12867
743722013469	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
743722013470	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
743722013471	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
743722013472	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013473	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722013474	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722013475	N-terminal plug; other site
743722013476	ligand-binding site [chemical binding]; other site
743722013477	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
743722013478	PIF1-like helicase; Region: PIF1; pfam05970
743722013479	Walker A motif; other site
743722013480	ATP binding site [chemical binding]; other site
743722013481	Walker B motif; other site
743722013482	Family description; Region: UvrD_C_2; pfam13538
743722013483	HRDC domain; Region: HRDC; pfam00570
743722013484	MutS domain III; Region: MutS_III; cl17822
743722013485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722013486	Walker A/P-loop; other site
743722013487	ATP binding site [chemical binding]; other site
743722013488	Q-loop/lid; other site
743722013489	ABC transporter signature motif; other site
743722013490	Walker B; other site
743722013491	D-loop; other site
743722013492	H-loop/switch region; other site
743722013493	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
743722013494	amphipathic channel; other site
743722013495	Asn-Pro-Ala signature motifs; other site
743722013496	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
743722013497	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
743722013498	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
743722013499	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
743722013500	endonuclease III; Region: ENDO3c; smart00478
743722013501	minor groove reading motif; other site
743722013502	helix-hairpin-helix signature motif; other site
743722013503	substrate binding pocket [chemical binding]; other site
743722013504	active site
743722013505	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
743722013506	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
743722013507	active site
743722013508	Glucokinase; Region: Glucokinase; pfam02685
743722013509	glucokinase, proteobacterial type; Region: glk; TIGR00749
743722013510	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
743722013511	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
743722013512	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
743722013513	Flavoprotein; Region: Flavoprotein; pfam02441
743722013514	Transcriptional regulators [Transcription]; Region: PurR; COG1609
743722013515	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
743722013516	DNA binding site [nucleotide binding]
743722013517	domain linker motif; other site
743722013518	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
743722013519	dimerization interface [polypeptide binding]; other site
743722013520	ligand binding site [chemical binding]; other site
743722013521	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013522	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013523	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722013524	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722013525	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013526	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013527	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013528	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013529	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
743722013530	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722013531	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013532	starch binding outer membrane protein SusD; Region: SusD; cl17845
743722013533	SusD family; Region: SusD; pfam07980
743722013534	fructuronate transporter; Provisional; Region: PRK10034; cl15264
743722013535	GntP family permease; Region: GntP_permease; pfam02447
743722013536	FOG: CBS domain [General function prediction only]; Region: COG0517
743722013537	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
743722013538	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
743722013539	metal binding triad; other site
743722013540	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
743722013541	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
743722013542	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
743722013543	active site
743722013544	catalytic site [active]
743722013545	substrate binding site [chemical binding]; other site
743722013546	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
743722013547	Response regulator receiver domain; Region: Response_reg; pfam00072
743722013548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013549	active site
743722013550	phosphorylation site [posttranslational modification]
743722013551	intermolecular recognition site; other site
743722013552	dimerization interface [polypeptide binding]; other site
743722013553	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
743722013554	PAS domain; Region: PAS_9; pfam13426
743722013555	putative active site [active]
743722013556	heme pocket [chemical binding]; other site
743722013557	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
743722013558	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
743722013559	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722013560	dimer interface [polypeptide binding]; other site
743722013561	phosphorylation site [posttranslational modification]
743722013562	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722013563	ATP binding site [chemical binding]; other site
743722013564	Mg2+ binding site [ion binding]; other site
743722013565	G-X-G motif; other site
743722013566	Response regulator receiver domain; Region: Response_reg; pfam00072
743722013567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013568	active site
743722013569	phosphorylation site [posttranslational modification]
743722013570	intermolecular recognition site; other site
743722013571	dimerization interface [polypeptide binding]; other site
743722013572	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
743722013573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
743722013574	active site
743722013575	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
743722013576	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
743722013577	Ligand binding site; other site
743722013578	Putative Catalytic site; other site
743722013579	DXD motif; other site
743722013580	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
743722013581	dihydroorotase; Validated; Region: pyrC; PRK09357
743722013582	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
743722013583	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
743722013584	active site
743722013585	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
743722013586	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
743722013587	ligand binding site; other site
743722013588	oligomer interface; other site
743722013589	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
743722013590	dimer interface [polypeptide binding]; other site
743722013591	N-terminal domain interface [polypeptide binding]; other site
743722013592	sulfate 1 binding site; other site
743722013593	glycogen synthase; Provisional; Region: glgA; PRK00654
743722013594	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
743722013595	ADP-binding pocket [chemical binding]; other site
743722013596	homodimer interface [polypeptide binding]; other site
743722013597	glycogen branching enzyme; Provisional; Region: PRK12313
743722013598	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
743722013599	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
743722013600	active site
743722013601	catalytic site [active]
743722013602	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
743722013603	putative alpha-glucosidase; Provisional; Region: PRK10658
743722013604	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
743722013605	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
743722013606	trimer interface [polypeptide binding]; other site
743722013607	active site
743722013608	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
743722013609	catalytic site [active]
743722013610	acyltransferase PapA5; Provisional; Region: PRK09294
743722013611	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
743722013612	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
743722013613	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
743722013614	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
743722013615	histidinol dehydrogenase; Region: hisD; TIGR00069
743722013616	NAD binding site [chemical binding]; other site
743722013617	dimerization interface [polypeptide binding]; other site
743722013618	product binding site; other site
743722013619	substrate binding site [chemical binding]; other site
743722013620	zinc binding site [ion binding]; other site
743722013621	catalytic residues [active]
743722013622	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
743722013623	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
743722013624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722013625	homodimer interface [polypeptide binding]; other site
743722013626	catalytic residue [active]
743722013627	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
743722013628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722013629	active site
743722013630	motif I; other site
743722013631	motif II; other site
743722013632	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
743722013633	putative active site pocket [active]
743722013634	4-fold oligomerization interface [polypeptide binding]; other site
743722013635	metal binding residues [ion binding]; metal-binding site
743722013636	3-fold/trimer interface [polypeptide binding]; other site
743722013637	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
743722013638	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
743722013639	putative active site [active]
743722013640	oxyanion strand; other site
743722013641	catalytic triad [active]
743722013642	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
743722013643	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
743722013644	catalytic residues [active]
743722013645	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
743722013646	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
743722013647	substrate binding site [chemical binding]; other site
743722013648	glutamase interaction surface [polypeptide binding]; other site
743722013649	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
743722013650	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
743722013651	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
743722013652	metal binding site [ion binding]; metal-binding site
743722013653	FOG: WD40 repeat [General function prediction only]; Region: COG2319
743722013654	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
743722013655	structural tetrad; other site
743722013656	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013657	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
743722013658	Zn binding site [ion binding]; other site
743722013659	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
743722013660	ArsC family; Region: ArsC; pfam03960
743722013661	putative catalytic residues [active]
743722013662	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
743722013663	putative active site [active]
743722013664	catalytic residue [active]
743722013665	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
743722013666	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
743722013667	5S rRNA interface [nucleotide binding]; other site
743722013668	CTC domain interface [polypeptide binding]; other site
743722013669	L16 interface [polypeptide binding]; other site
743722013670	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
743722013671	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
743722013672	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
743722013673	active site
743722013674	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
743722013675	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
743722013676	active site
743722013677	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
743722013678	short chain dehydrogenase; Provisional; Region: PRK12828
743722013679	classical (c) SDRs; Region: SDR_c; cd05233
743722013680	NAD(P) binding site [chemical binding]; other site
743722013681	active site
743722013682	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
743722013683	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
743722013684	dimer interface [polypeptide binding]; other site
743722013685	ssDNA binding site [nucleotide binding]; other site
743722013686	tetramer (dimer of dimers) interface [polypeptide binding]; other site
743722013687	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
743722013688	metal binding site [ion binding]; metal-binding site
743722013689	OsmC-like protein; Region: OsmC; cl00767
743722013690	Uncharacterized conserved protein, YhbC family [Function unknown]; Region: COG0782
743722013691	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
743722013692	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
743722013693	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
743722013694	N-terminal plug; other site
743722013695	ligand-binding site [chemical binding]; other site
743722013696	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
743722013697	Cna protein B-type domain; Region: Cna_B_2; pfam13715
743722013698	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
743722013699	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
743722013700	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
743722013701	starch binding outer membrane protein SusD; Region: SusD; cd08977
743722013702	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
743722013703	Sulfatase; Region: Sulfatase; pfam00884
743722013704	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
743722013705	catalytic site [active]
743722013706	BNR repeat-like domain; Region: BNR_2; pfam13088
743722013707	Asp-box motif; other site
743722013708	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
743722013709	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
743722013710	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
743722013711	CsbD-like; Region: CsbD; pfam05532
743722013712	acetyl-CoA synthetase; Provisional; Region: PRK00174
743722013713	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
743722013714	active site
743722013715	CoA binding site [chemical binding]; other site
743722013716	acyl-activating enzyme (AAE) consensus motif; other site
743722013717	AMP binding site [chemical binding]; other site
743722013718	acetate binding site [chemical binding]; other site
743722013719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722013720	putative substrate translocation pore; other site
743722013721	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
743722013722	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
743722013723	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
743722013724	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
743722013725	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
743722013726	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
743722013727	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
743722013728	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
743722013729	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722013730	FeS/SAM binding site; other site
743722013731	TRAM domain; Region: TRAM; cl01282
743722013732	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
743722013733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
743722013734	Protein of unknown function (DUF419); Region: DUF419; pfam04237
743722013735	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
743722013736	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
743722013737	Membrane protein of unknown function; Region: DUF360; pfam04020
743722013738	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
743722013739	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
743722013740	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
743722013741	substrate binding site [chemical binding]; other site
743722013742	active site
743722013743	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
743722013744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
743722013745	active site
743722013746	phosphorylation site [posttranslational modification]
743722013747	intermolecular recognition site; other site
743722013748	dimerization interface [polypeptide binding]; other site
743722013749	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
743722013750	DNA binding site [nucleotide binding]
743722013751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
743722013752	dimer interface [polypeptide binding]; other site
743722013753	phosphorylation site [posttranslational modification]
743722013754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
743722013755	ATP binding site [chemical binding]; other site
743722013756	Mg2+ binding site [ion binding]; other site
743722013757	G-X-G motif; other site
743722013758	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
743722013759	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
743722013760	inhibitor-cofactor binding pocket; inhibition site
743722013761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
743722013762	catalytic residue [active]
743722013763	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
743722013764	dimer interface [polypeptide binding]; other site
743722013765	active site
743722013766	Schiff base residues; other site
743722013767	Porphobilinogen deaminase [Coenzyme metabolism]; Region: HemC; COG0181
743722013768	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
743722013769	domain interfaces; other site
743722013770	active site
743722013771	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
743722013772	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
743722013773	active site
743722013774	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
743722013775	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
743722013776	tRNA; other site
743722013777	putative tRNA binding site [nucleotide binding]; other site
743722013778	putative NADP binding site [chemical binding]; other site
743722013779	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
743722013780	periplasmic chaperone; Provisional; Region: PRK10780
743722013781	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
743722013782	periplasmic chaperone; Provisional; Region: PRK10780
743722013783	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
743722013784	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
743722013785	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
743722013786	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
743722013787	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
743722013788	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
743722013789	Surface antigen; Region: Bac_surface_Ag; pfam01103
743722013790	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
743722013791	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
743722013792	catalytic residue [active]
743722013793	putative FPP diphosphate  binding site; other site
743722013794	putative FPP binding hydrophobic cleft; other site
743722013795	dimer interface [polypeptide binding]; other site
743722013796	putative IPP diphosphate binding site; other site
743722013797	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722013798	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
743722013799	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
743722013800	FOG: CBS domain [General function prediction only]; Region: COG0517
743722013801	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
743722013802	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
743722013803	Yqey-like protein; Region: YqeY; pfam09424
743722013804	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
743722013805	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
743722013806	putative NAD(P) binding site [chemical binding]; other site
743722013807	homodimer interface [polypeptide binding]; other site
743722013808	homotetramer interface [polypeptide binding]; other site
743722013809	active site
743722013810	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722013811	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
743722013812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
743722013813	S-adenosylmethionine binding site [chemical binding]; other site
743722013814	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
743722013815	G1 box; other site
743722013816	GTP/Mg2+ binding site [chemical binding]; other site
743722013817	Switch I region; other site
743722013818	G2 box; other site
743722013819	G3 box; other site
743722013820	Switch II region; other site
743722013821	G4 box; other site
743722013822	G5 box; other site
743722013823	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
743722013824	UbiA prenyltransferase family; Region: UbiA; pfam01040
743722013825	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
743722013826	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
743722013827	active site
743722013828	Zn binding site [ion binding]; other site
743722013829	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
743722013830	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
743722013831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
743722013832	motif II; other site
743722013833	Peptidase family M49; Region: Peptidase_M49; pfam03571
743722013834	seryl-tRNA synthetase; Provisional; Region: PRK05431
743722013835	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
743722013836	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
743722013837	dimer interface [polypeptide binding]; other site
743722013838	active site
743722013839	motif 1; other site
743722013840	motif 2; other site
743722013841	motif 3; other site
743722013842	Predicted methyltransferases [General function prediction only]; Region: COG0313
743722013843	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
743722013844	putative SAM binding site [chemical binding]; other site
743722013845	putative homodimer interface [polypeptide binding]; other site
743722013846	Short C-terminal domain; Region: SHOCT; pfam09851
743722013847	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
743722013848	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
743722013849	putative active site [active]
743722013850	catalytic triad [active]
743722013851	putative dimer interface [polypeptide binding]; other site
743722013852	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
743722013853	NAD synthetase; Provisional; Region: PRK13981
743722013854	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
743722013855	multimer interface [polypeptide binding]; other site
743722013856	active site
743722013857	catalytic triad [active]
743722013858	protein interface 1 [polypeptide binding]; other site
743722013859	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
743722013860	homodimer interface [polypeptide binding]; other site
743722013861	NAD binding pocket [chemical binding]; other site
743722013862	ATP binding pocket [chemical binding]; other site
743722013863	Mg binding site [ion binding]; other site
743722013864	active-site loop [active]
743722013865	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
743722013866	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
743722013867	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
743722013868	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
743722013869	core domain interface [polypeptide binding]; other site
743722013870	delta subunit interface [polypeptide binding]; other site
743722013871	epsilon subunit interface [polypeptide binding]; other site
743722013872	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
743722013873	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
743722013874	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
743722013875	beta subunit interaction interface [polypeptide binding]; other site
743722013876	Walker A motif; other site
743722013877	ATP binding site [chemical binding]; other site
743722013878	Walker B motif; other site
743722013879	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
743722013880	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
743722013881	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
743722013882	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
743722013883	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
743722013884	ATP synthase A chain; Region: ATP-synt_A; cl00413
743722013885	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
743722013886	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
743722013887	binding surface
743722013888	TPR motif; other site
743722013889	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
743722013890	binding surface
743722013891	TPR motif; other site
743722013892	Tetratricopeptide repeat; Region: TPR_12; pfam13424
743722013893	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
743722013894	Transglycosylase; Region: Transgly; pfam00912
743722013895	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
743722013896	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
743722013897	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
743722013898	GIY-YIG motif/motif A; other site
743722013899	active site
743722013900	catalytic site [active]
743722013901	putative DNA binding site [nucleotide binding]; other site
743722013902	metal binding site [ion binding]; metal-binding site
743722013903	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
743722013904	gliding motility associated protien GldN; Region: GldN; TIGR03523
743722013905	gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525
743722013906	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
743722013907	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
743722013908	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
743722013909	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
743722013910	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
743722013911	active site
743722013912	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
743722013913	succinic semialdehyde dehydrogenase; Region: PLN02278
743722013914	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
743722013915	tetramerization interface [polypeptide binding]; other site
743722013916	NAD(P) binding site [chemical binding]; other site
743722013917	catalytic residues [active]
743722013918	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
743722013919	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
743722013920	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
743722013921	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
743722013922	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
743722013923	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
743722013924	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
743722013925	oligomer interface [polypeptide binding]; other site
743722013926	active site
743722013927	metal binding site [ion binding]; metal-binding site
743722013928	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
743722013929	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
743722013930	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
743722013931	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
743722013932	dihydropteroate synthase; Region: DHPS; TIGR01496
743722013933	substrate binding pocket [chemical binding]; other site
743722013934	dimer interface [polypeptide binding]; other site
743722013935	inhibitor binding site; inhibition site
743722013936	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
743722013937	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
743722013938	shikimate kinase; Reviewed; Region: aroK; PRK00131
743722013939	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
743722013940	ADP binding site [chemical binding]; other site
743722013941	magnesium binding site [ion binding]; other site
743722013942	putative shikimate binding site; other site
743722013943	Protein of unknown function (DUF721); Region: DUF721; pfam05258
743722013944	recombination protein F; Reviewed; Region: recF; PRK00064
743722013945	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722013946	Walker A/P-loop; other site
743722013947	ATP binding site [chemical binding]; other site
743722013948	Q-loop/lid; other site
743722013949	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
743722013950	ABC transporter signature motif; other site
743722013951	Walker B; other site
743722013952	D-loop; other site
743722013953	H-loop/switch region; other site
743722013954	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
743722013955	homopentamer interface [polypeptide binding]; other site
743722013956	active site
743722013957	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
743722013958	OsmC-like protein; Region: OsmC; pfam02566
743722013959	lipoyl synthase; Provisional; Region: PRK05481
743722013960	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
743722013961	FeS/SAM binding site; other site
743722013962	hypothetical protein; Provisional; Region: PHA02695; cl17648
743722013963	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
743722013964	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
743722013965	putative substrate binding site [chemical binding]; other site
743722013966	putative ATP binding site [chemical binding]; other site
743722013967	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
743722013968	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
743722013969	THF binding site; other site
743722013970	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
743722013971	substrate binding site [chemical binding]; other site
743722013972	THF binding site; other site
743722013973	zinc-binding site [ion binding]; other site
743722013974	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
743722013975	TrkA-C domain; Region: TrkA_C; pfam02080
743722013976	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
743722013977	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
743722013978	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
743722013979	MgtC family; Region: MgtC; pfam02308
743722013980	Domain of unknown function DUF59; Region: DUF59; cl00941
743722013981	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
743722013982	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743722013983	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
743722013984	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
743722013985	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
743722013986	N-acetyl-D-glucosamine binding site [chemical binding]; other site
743722013987	catalytic residue [active]
743722013988	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
743722013989	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
743722013990	active site