-- dump date 20140620_071705 -- class Genbank::misc_feature -- table misc_feature_note -- id note 690566000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 690566000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 690566000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566000004 Walker A motif; other site 690566000005 ATP binding site [chemical binding]; other site 690566000006 Walker B motif; other site 690566000007 arginine finger; other site 690566000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 690566000009 DnaA box-binding interface [nucleotide binding]; other site 690566000010 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 690566000011 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 690566000012 active site 690566000013 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 690566000014 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 690566000015 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 690566000016 active site 690566000017 HIGH motif; other site 690566000018 dimer interface [polypeptide binding]; other site 690566000019 KMSKS motif; other site 690566000020 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 690566000021 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 690566000022 Preprotein translocase subunit SecB; Region: SecB; pfam02556 690566000023 SecA binding site; other site 690566000024 Preprotein binding site; other site 690566000025 Tim44-like domain; Region: Tim44; pfam04280 690566000026 MltA specific insert domain; Region: MltA; smart00925 690566000027 3D domain; Region: 3D; pfam06725 690566000028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 690566000029 Smr domain; Region: Smr; pfam01713 690566000030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566000031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566000032 metal binding site [ion binding]; metal-binding site 690566000033 active site 690566000034 I-site; other site 690566000035 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566000036 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 690566000037 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 690566000038 metal binding site [ion binding]; metal-binding site 690566000039 dimer interface [polypeptide binding]; other site 690566000040 Cupin domain; Region: Cupin_2; cl17218 690566000041 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 690566000042 dimer interface [polypeptide binding]; other site 690566000043 catalytic triad [active] 690566000044 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 690566000045 IHF dimer interface [polypeptide binding]; other site 690566000046 IHF - DNA interface [nucleotide binding]; other site 690566000047 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 690566000048 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 690566000049 DNA binding residues [nucleotide binding] 690566000050 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 690566000051 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 690566000052 catalytic core [active] 690566000053 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 690566000054 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 690566000055 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 690566000056 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 690566000057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566000058 active site 690566000059 nucleotide binding site [chemical binding]; other site 690566000060 HIGH motif; other site 690566000061 KMSKS motif; other site 690566000062 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 690566000063 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 690566000064 putative active site [active] 690566000065 putative PHP Thumb interface [polypeptide binding]; other site 690566000066 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 690566000067 generic binding surface II; other site 690566000068 generic binding surface I; other site 690566000069 DNA Polymerase Y-family; Region: PolY_like; cd03468 690566000070 active site 690566000071 DNA binding site [nucleotide binding] 690566000072 Uncharacterized conserved protein [Function unknown]; Region: COG4544 690566000073 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 690566000074 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 690566000075 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 690566000076 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 690566000077 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 690566000078 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 690566000079 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 690566000080 active site 690566000081 metal binding site [ion binding]; metal-binding site 690566000082 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 690566000083 Transglycosylase; Region: Transgly; pfam00912 690566000084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 690566000085 peptide chain release factor 2; Validated; Region: prfB; PRK00578 690566000086 This domain is found in peptide chain release factors; Region: PCRF; smart00937 690566000087 RF-1 domain; Region: RF-1; pfam00472 690566000088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566000089 S-adenosylmethionine binding site [chemical binding]; other site 690566000090 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 690566000091 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 690566000092 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 690566000093 G1 box; other site 690566000094 putative GEF interaction site [polypeptide binding]; other site 690566000095 GTP/Mg2+ binding site [chemical binding]; other site 690566000096 Switch I region; other site 690566000097 G2 box; other site 690566000098 G3 box; other site 690566000099 Switch II region; other site 690566000100 G4 box; other site 690566000101 G5 box; other site 690566000102 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 690566000103 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 690566000104 Protein of unknown function (DUF805); Region: DUF805; pfam05656 690566000105 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 690566000106 Nucleoside recognition; Region: Gate; pfam07670 690566000107 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 690566000108 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 690566000109 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 690566000110 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 690566000111 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 690566000112 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 690566000113 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566000114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566000115 metal binding site [ion binding]; metal-binding site 690566000116 active site 690566000117 I-site; other site 690566000118 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 690566000119 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 690566000120 active site 690566000121 HIGH motif; other site 690566000122 nucleotide binding site [chemical binding]; other site 690566000123 active site 690566000124 KMSKS motif; other site 690566000125 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 690566000126 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 690566000127 active site 690566000128 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566000129 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566000130 ligand binding site [chemical binding]; other site 690566000131 flexible hinge region; other site 690566000132 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 690566000133 putative switch regulator; other site 690566000134 non-specific DNA interactions [nucleotide binding]; other site 690566000135 DNA binding site [nucleotide binding] 690566000136 sequence specific DNA binding site [nucleotide binding]; other site 690566000137 putative cAMP binding site [chemical binding]; other site 690566000138 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 690566000139 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566000140 active site 690566000141 HIGH motif; other site 690566000142 nucleotide binding site [chemical binding]; other site 690566000143 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 690566000144 active site 690566000145 KMSKS motif; other site 690566000146 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 690566000147 tRNA binding surface [nucleotide binding]; other site 690566000148 anticodon binding site; other site 690566000149 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 690566000150 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 690566000151 Domain of unknown function DUF87; Region: DUF87; pfam01935 690566000152 AAA-like domain; Region: AAA_10; pfam12846 690566000153 Acyltransferase family; Region: Acyl_transf_3; pfam01757 690566000154 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 690566000155 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566000156 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 690566000157 putative binding surface; other site 690566000158 active site 690566000159 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 690566000160 CPxP motif; other site 690566000161 GTP-binding protein Der; Reviewed; Region: PRK00093 690566000162 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 690566000163 G1 box; other site 690566000164 GTP/Mg2+ binding site [chemical binding]; other site 690566000165 Switch I region; other site 690566000166 G2 box; other site 690566000167 Switch II region; other site 690566000168 G3 box; other site 690566000169 G4 box; other site 690566000170 G5 box; other site 690566000171 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 690566000172 G1 box; other site 690566000173 GTP/Mg2+ binding site [chemical binding]; other site 690566000174 Switch I region; other site 690566000175 G2 box; other site 690566000176 G3 box; other site 690566000177 Switch II region; other site 690566000178 G4 box; other site 690566000179 G5 box; other site 690566000180 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 690566000181 Trp docking motif [polypeptide binding]; other site 690566000182 active site 690566000183 PQQ-like domain; Region: PQQ_2; pfam13360 690566000184 PQQ-like domain; Region: PQQ_2; pfam13360 690566000185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 690566000186 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 690566000187 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 690566000188 oligomerization interface [polypeptide binding]; other site 690566000189 active site 690566000190 metal binding site [ion binding]; metal-binding site 690566000191 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566000192 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000193 N-terminal plug; other site 690566000194 ligand-binding site [chemical binding]; other site 690566000195 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 690566000196 Serine hydrolase; Region: Ser_hydrolase; pfam06821 690566000197 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566000198 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 690566000199 EamA-like transporter family; Region: EamA; cl17759 690566000200 Predicted methyltransferase [General function prediction only]; Region: COG4798 690566000201 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566000202 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 690566000203 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566000204 ATP binding site [chemical binding]; other site 690566000205 Walker A motif; other site 690566000206 hexamer interface [polypeptide binding]; other site 690566000207 Walker B motif; other site 690566000208 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 690566000209 gamma subunit interface [polypeptide binding]; other site 690566000210 epsilon subunit interface [polypeptide binding]; other site 690566000211 LBP interface [polypeptide binding]; other site 690566000212 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 690566000213 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 690566000214 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 690566000215 alpha subunit interaction interface [polypeptide binding]; other site 690566000216 Walker A motif; other site 690566000217 ATP binding site [chemical binding]; other site 690566000218 Walker B motif; other site 690566000219 inhibitor binding site; inhibition site 690566000220 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 690566000221 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 690566000222 core domain interface [polypeptide binding]; other site 690566000223 delta subunit interface [polypeptide binding]; other site 690566000224 epsilon subunit interface [polypeptide binding]; other site 690566000225 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 690566000226 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 690566000227 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 690566000228 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 690566000229 beta subunit interaction interface [polypeptide binding]; other site 690566000230 Walker A motif; other site 690566000231 ATP binding site [chemical binding]; other site 690566000232 Walker B motif; other site 690566000233 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 690566000234 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 690566000235 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 690566000236 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 690566000237 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 690566000238 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 690566000239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566000240 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 690566000241 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 690566000242 DNA binding site [nucleotide binding] 690566000243 active site 690566000244 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 690566000245 primosome assembly protein PriA; Validated; Region: PRK05580 690566000246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566000247 ATP binding site [chemical binding]; other site 690566000248 putative Mg++ binding site [ion binding]; other site 690566000249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 690566000250 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 690566000251 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 690566000252 active site 690566000253 intersubunit interactions; other site 690566000254 catalytic residue [active] 690566000255 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 690566000256 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 690566000257 Transcriptional regulators [Transcription]; Region: FadR; COG2186 690566000258 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566000259 DNA-binding site [nucleotide binding]; DNA binding site 690566000260 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 690566000261 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 690566000262 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 690566000263 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 690566000264 23S rRNA interface [nucleotide binding]; other site 690566000265 L3 interface [polypeptide binding]; other site 690566000266 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 690566000267 CcmB protein; Region: CcmB; cl17444 690566000268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566000269 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 690566000270 Walker A/P-loop; other site 690566000271 ATP binding site [chemical binding]; other site 690566000272 Q-loop/lid; other site 690566000273 ABC transporter signature motif; other site 690566000274 Walker B; other site 690566000275 D-loop; other site 690566000276 H-loop/switch region; other site 690566000277 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 690566000278 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 690566000279 aromatic arch; other site 690566000280 DCoH dimer interaction site [polypeptide binding]; other site 690566000281 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 690566000282 DCoH tetramer interaction site [polypeptide binding]; other site 690566000283 substrate binding site [chemical binding]; other site 690566000284 patatin-related protein; Region: TIGR03607 690566000285 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 690566000286 putative catalytic site [active] 690566000287 putative metal binding site [ion binding]; other site 690566000288 putative phosphate binding site [ion binding]; other site 690566000289 DNA repair protein RadA; Provisional; Region: PRK11823 690566000290 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566000291 Walker A motif; other site 690566000292 ATP binding site [chemical binding]; other site 690566000293 Walker B motif; other site 690566000294 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 690566000295 Colicin V production protein; Region: Colicin_V; pfam02674 690566000296 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 690566000297 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 690566000298 NAD(P) binding site [chemical binding]; other site 690566000299 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 690566000300 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566000301 dimer interface [polypeptide binding]; other site 690566000302 active site 690566000303 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 690566000304 putative active site [active] 690566000305 putative catalytic site [active] 690566000306 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 690566000307 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566000308 active site 690566000309 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 690566000310 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566000311 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566000312 active site 690566000313 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566000314 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 690566000315 FAD binding site [chemical binding]; other site 690566000316 substrate binding site [chemical binding]; other site 690566000317 catalytic base [active] 690566000318 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 690566000319 active site 690566000320 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 690566000321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566000322 acyl-activating enzyme (AAE) consensus motif; other site 690566000323 AMP binding site [chemical binding]; other site 690566000324 active site 690566000325 CoA binding site [chemical binding]; other site 690566000326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000327 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566000328 substrate binding site [chemical binding]; other site 690566000329 oxyanion hole (OAH) forming residues; other site 690566000330 trimer interface [polypeptide binding]; other site 690566000331 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566000332 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566000333 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566000334 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566000335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000336 NAD(P) binding site [chemical binding]; other site 690566000337 active site 690566000338 Sensors of blue-light using FAD; Region: BLUF; pfam04940 690566000339 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 690566000340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566000341 active site 690566000342 phosphorylation site [posttranslational modification] 690566000343 intermolecular recognition site; other site 690566000344 dimerization interface [polypeptide binding]; other site 690566000345 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566000346 DNA binding residues [nucleotide binding] 690566000347 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 690566000348 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 690566000349 active site 690566000350 catalytic site [active] 690566000351 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 690566000352 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566000353 Sulfatase; Region: Sulfatase; pfam00884 690566000354 Cytochrome c2 [Energy production and conversion]; Region: COG3474 690566000355 Predicted small integral membrane protein [Function unknown]; Region: COG5605 690566000356 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864 690566000357 Subunit I/III interface [polypeptide binding]; other site 690566000358 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 690566000359 Subunit I/III interface [polypeptide binding]; other site 690566000360 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 690566000361 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 690566000362 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 690566000363 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 690566000364 TadE-like protein; Region: TadE; pfam07811 690566000365 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 690566000366 TadE-like protein; Region: TadE; pfam07811 690566000367 rod shape-determining protein MreB; Provisional; Region: PRK13927 690566000368 MreB and similar proteins; Region: MreB_like; cd10225 690566000369 nucleotide binding site [chemical binding]; other site 690566000370 Mg binding site [ion binding]; other site 690566000371 putative protofilament interaction site [polypeptide binding]; other site 690566000372 RodZ interaction site [polypeptide binding]; other site 690566000373 fructose-1,6-bisphosphatase family protein; Region: PLN02628 690566000374 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 690566000375 AMP binding site [chemical binding]; other site 690566000376 metal binding site [ion binding]; metal-binding site 690566000377 active site 690566000378 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 690566000379 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566000380 bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716 690566000381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566000382 active site 690566000383 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 690566000384 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 690566000385 Low affinity iron permease; Region: Iron_permease; pfam04120 690566000386 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 690566000387 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 690566000388 CoA-ligase; Region: Ligase_CoA; pfam00549 690566000389 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 690566000390 Ligand binding site [chemical binding]; other site 690566000391 Electron transfer flavoprotein domain; Region: ETF; pfam01012 690566000392 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 690566000393 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 690566000394 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 690566000395 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 690566000396 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 690566000397 recA bacterial DNA recombination protein; Region: RecA; cl17211 690566000398 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 690566000399 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 690566000400 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 690566000401 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 690566000402 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 690566000403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566000404 active site 690566000405 phosphorylation site [posttranslational modification] 690566000406 intermolecular recognition site; other site 690566000407 dimerization interface [polypeptide binding]; other site 690566000408 LytTr DNA-binding domain; Region: LytTR; smart00850 690566000409 Histidine kinase; Region: His_kinase; pfam06580 690566000410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566000411 ATP binding site [chemical binding]; other site 690566000412 Mg2+ binding site [ion binding]; other site 690566000413 G-X-G motif; other site 690566000414 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 690566000415 Competence-damaged protein; Region: CinA; pfam02464 690566000416 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566000417 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566000418 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566000419 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000420 N-terminal plug; other site 690566000421 ligand-binding site [chemical binding]; other site 690566000422 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 690566000423 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 690566000424 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 690566000425 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 690566000426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 690566000427 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 690566000428 Walker A/P-loop; other site 690566000429 ATP binding site [chemical binding]; other site 690566000430 Q-loop/lid; other site 690566000431 ABC transporter signature motif; other site 690566000432 Walker B; other site 690566000433 D-loop; other site 690566000434 H-loop/switch region; other site 690566000435 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566000436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000437 N-terminal plug; other site 690566000438 ligand-binding site [chemical binding]; other site 690566000439 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 690566000440 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 690566000441 putative NAD(P) binding site [chemical binding]; other site 690566000442 catalytic Zn binding site [ion binding]; other site 690566000443 Cupin domain; Region: Cupin_2; cl17218 690566000444 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566000445 classical (c) SDRs; Region: SDR_c; cd05233 690566000446 NAD(P) binding site [chemical binding]; other site 690566000447 active site 690566000448 Ecdysteroid kinase; Region: EcKinase; cl17738 690566000449 Phosphotransferase enzyme family; Region: APH; pfam01636 690566000450 Protein of unknown function (DUF422); Region: DUF422; cl00991 690566000451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566000452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566000453 WHG domain; Region: WHG; pfam13305 690566000454 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 690566000455 Fatty acid desaturase; Region: FA_desaturase; pfam00487 690566000456 putative di-iron ligands [ion binding]; other site 690566000457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566000458 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 690566000459 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566000460 acyl-activating enzyme (AAE) consensus motif; other site 690566000461 acyl-activating enzyme (AAE) consensus motif; other site 690566000462 putative AMP binding site [chemical binding]; other site 690566000463 putative active site [active] 690566000464 putative CoA binding site [chemical binding]; other site 690566000465 CoA binding site [chemical binding]; other site 690566000466 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 690566000467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000468 NAD(P) binding site [chemical binding]; other site 690566000469 active site 690566000470 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 690566000471 NAD(P) binding site [chemical binding]; other site 690566000472 catalytic residues [active] 690566000473 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566000474 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000475 N-terminal plug; other site 690566000476 ligand-binding site [chemical binding]; other site 690566000477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566000478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566000479 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566000480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000481 substrate binding site [chemical binding]; other site 690566000482 oxyanion hole (OAH) forming residues; other site 690566000483 trimer interface [polypeptide binding]; other site 690566000484 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566000485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000486 substrate binding site [chemical binding]; other site 690566000487 oxyanion hole (OAH) forming residues; other site 690566000488 trimer interface [polypeptide binding]; other site 690566000489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 690566000491 NAD(P) binding site [chemical binding]; other site 690566000492 active site 690566000493 feruloyl-CoA synthase; Reviewed; Region: PRK08180 690566000494 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566000495 acyl-activating enzyme (AAE) consensus motif; other site 690566000496 AMP binding site [chemical binding]; other site 690566000497 active site 690566000498 CoA binding site [chemical binding]; other site 690566000499 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 690566000500 CoenzymeA binding site [chemical binding]; other site 690566000501 subunit interaction site [polypeptide binding]; other site 690566000502 PHB binding site; other site 690566000503 short chain dehydrogenase; Provisional; Region: PRK07576 690566000504 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 690566000505 NAD(P) binding site [chemical binding]; other site 690566000506 substrate binding site [chemical binding]; other site 690566000507 homotetramer interface [polypeptide binding]; other site 690566000508 active site 690566000509 homodimer interface [polypeptide binding]; other site 690566000510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566000511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566000512 active site 690566000513 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 690566000514 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566000515 FMN binding site [chemical binding]; other site 690566000516 substrate binding site [chemical binding]; other site 690566000517 putative catalytic residue [active] 690566000518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566000519 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566000520 active site 690566000521 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 690566000522 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566000523 dimer interface [polypeptide binding]; other site 690566000524 active site 690566000525 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566000526 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000527 substrate binding site [chemical binding]; other site 690566000528 oxyanion hole (OAH) forming residues; other site 690566000529 trimer interface [polypeptide binding]; other site 690566000530 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566000531 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566000532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000533 NAD(P) binding site [chemical binding]; other site 690566000534 active site 690566000535 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566000536 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000537 substrate binding site [chemical binding]; other site 690566000538 oxyanion hole (OAH) forming residues; other site 690566000539 trimer interface [polypeptide binding]; other site 690566000540 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566000541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000542 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566000543 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566000544 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 690566000545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566000546 PAS domain; Region: PAS_9; pfam13426 690566000547 putative active site [active] 690566000548 heme pocket [chemical binding]; other site 690566000549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 690566000550 dimer interface [polypeptide binding]; other site 690566000551 putative CheW interface [polypeptide binding]; other site 690566000552 S-adenosylmethionine synthetase; Validated; Region: PRK05250 690566000553 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 690566000554 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 690566000555 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 690566000556 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 690566000557 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 690566000558 putative active site [active] 690566000559 catalytic triad [active] 690566000560 putative dimer interface [polypeptide binding]; other site 690566000561 Predicted membrane protein [Function unknown]; Region: COG1238 690566000562 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 690566000563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 690566000564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 690566000565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 690566000566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566000567 Coenzyme A binding pocket [chemical binding]; other site 690566000568 Uncharacterized conserved protein [Function unknown]; Region: COG5323 690566000569 Terminase-like family; Region: Terminase_6; pfam03237 690566000570 Phage-related protein [Function unknown]; Region: COG4695; cl01923 690566000571 Phage portal protein; Region: Phage_portal; pfam04860 690566000572 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 690566000573 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 690566000574 Phage capsid family; Region: Phage_capsid; pfam05065 690566000575 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 690566000576 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 690566000577 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 690566000578 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 690566000579 Conserved hypothetical phage protein (DUF2376); Region: DUF2376; pfam09550 690566000580 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 690566000581 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 690566000582 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 690566000583 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 690566000584 Putative phage tail protein; Region: Phage-tail_3; pfam13550 690566000585 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 690566000586 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 690566000587 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 690566000588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566000589 ligand binding site [chemical binding]; other site 690566000590 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 690566000591 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 690566000592 E-class dimer interface [polypeptide binding]; other site 690566000593 P-class dimer interface [polypeptide binding]; other site 690566000594 active site 690566000595 Cu2+ binding site [ion binding]; other site 690566000596 Zn2+ binding site [ion binding]; other site 690566000597 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 690566000598 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 690566000599 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 690566000600 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 690566000601 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 690566000602 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566000603 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 690566000604 putative C-terminal domain interface [polypeptide binding]; other site 690566000605 putative GSH binding site (G-site) [chemical binding]; other site 690566000606 putative dimer interface [polypeptide binding]; other site 690566000607 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 690566000608 dimer interface [polypeptide binding]; other site 690566000609 N-terminal domain interface [polypeptide binding]; other site 690566000610 putative substrate binding pocket (H-site) [chemical binding]; other site 690566000611 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 690566000612 Clp amino terminal domain; Region: Clp_N; pfam02861 690566000613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566000614 Walker A motif; other site 690566000615 ATP binding site [chemical binding]; other site 690566000616 Walker B motif; other site 690566000617 arginine finger; other site 690566000618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566000619 Walker A motif; other site 690566000620 ATP binding site [chemical binding]; other site 690566000621 Walker B motif; other site 690566000622 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 690566000623 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 690566000624 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 690566000625 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 690566000626 NAD(P) binding site [chemical binding]; other site 690566000627 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566000628 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 690566000629 putative active site [active] 690566000630 putative metal binding site [ion binding]; other site 690566000631 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566000632 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 690566000633 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 690566000634 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 690566000635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566000636 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 690566000637 acyl-activating enzyme (AAE) consensus motif; other site 690566000638 putative AMP binding site [chemical binding]; other site 690566000639 putative active site [active] 690566000640 putative CoA binding site [chemical binding]; other site 690566000641 methionine sulfoxide reductase A; Provisional; Region: PRK14054 690566000642 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 690566000643 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 690566000644 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 690566000645 Protein of unknown function (DUF815); Region: DUF815; pfam05673 690566000646 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 690566000647 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 690566000648 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 690566000649 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 690566000650 NlpC/P60 family; Region: NLPC_P60; pfam00877 690566000651 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566000652 putative Zn2+ binding site [ion binding]; other site 690566000653 putative DNA binding site [nucleotide binding]; other site 690566000654 dimerization interface [polypeptide binding]; other site 690566000655 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 690566000656 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 690566000657 interface (dimer of trimers) [polypeptide binding]; other site 690566000658 Substrate-binding/catalytic site; other site 690566000659 Zn-binding sites [ion binding]; other site 690566000660 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 690566000661 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 690566000662 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 690566000663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566000664 FeS/SAM binding site; other site 690566000665 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 690566000666 seryl-tRNA synthetase; Provisional; Region: PRK05431 690566000667 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 690566000668 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 690566000669 dimer interface [polypeptide binding]; other site 690566000670 active site 690566000671 motif 1; other site 690566000672 motif 2; other site 690566000673 motif 3; other site 690566000674 Protein required for attachment to host cells; Region: Host_attach; pfam10116 690566000675 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 690566000676 PilZ domain; Region: PilZ; cl01260 690566000677 Protein of unknown function (DUF465); Region: DUF465; pfam04325 690566000678 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 690566000679 Protein of unknown function (DUF1465); Region: DUF1465; pfam07323 690566000680 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 690566000681 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566000682 Surface antigen; Region: Bac_surface_Ag; pfam01103 690566000683 Family of unknown function (DUF490); Region: DUF490; pfam04357 690566000684 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 690566000685 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 690566000686 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 690566000687 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 690566000688 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 690566000689 active site 690566000690 dimer interface [polypeptide binding]; other site 690566000691 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 690566000692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 690566000693 Pirin-related protein [General function prediction only]; Region: COG1741 690566000694 Pirin; Region: Pirin; pfam02678 690566000695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566000696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566000697 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 690566000698 putative effector binding pocket; other site 690566000699 dimerization interface [polypeptide binding]; other site 690566000700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566000701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566000702 active site 690566000703 phosphorylation site [posttranslational modification] 690566000704 intermolecular recognition site; other site 690566000705 dimerization interface [polypeptide binding]; other site 690566000706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566000707 DNA binding site [nucleotide binding] 690566000708 Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561 690566000709 active site 690566000710 catalytic triad [active] 690566000711 RNA polymerase sigma factor; Provisional; Region: PRK12547 690566000712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566000713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566000714 DNA binding residues [nucleotide binding] 690566000715 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 690566000716 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566000717 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000718 N-terminal plug; other site 690566000719 ligand-binding site [chemical binding]; other site 690566000720 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566000721 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 690566000722 active site 690566000723 metal binding site [ion binding]; metal-binding site 690566000724 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 690566000725 trimer interface [polypeptide binding]; other site 690566000726 active site 690566000727 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 690566000728 active site 690566000729 catalytic motif [active] 690566000730 Zn binding site [ion binding]; other site 690566000731 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 690566000732 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 690566000733 active site 690566000734 hypothetical protein; Provisional; Region: PRK02853 690566000735 replicative DNA helicase; Provisional; Region: PRK09165 690566000736 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 690566000737 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 690566000738 Walker A motif; other site 690566000739 ATP binding site [chemical binding]; other site 690566000740 Walker B motif; other site 690566000741 DNA binding loops [nucleotide binding] 690566000742 MAPEG family; Region: MAPEG; cl09190 690566000743 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 690566000744 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 690566000745 Active Sites [active] 690566000746 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 690566000747 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 690566000748 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 690566000749 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 690566000750 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 690566000751 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 690566000752 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 690566000753 active site 690566000754 SAM binding site [chemical binding]; other site 690566000755 homodimer interface [polypeptide binding]; other site 690566000756 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 690566000757 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 690566000758 NAD(P) binding site [chemical binding]; other site 690566000759 catalytic residues [active] 690566000760 hypothetical protein; Validated; Region: PRK00029 690566000761 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 690566000762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566000763 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 690566000764 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 690566000765 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566000766 FMN binding site [chemical binding]; other site 690566000767 substrate binding site [chemical binding]; other site 690566000768 putative catalytic residue [active] 690566000769 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 690566000770 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 690566000771 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 690566000772 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 690566000773 dihydroorotase; Validated; Region: PRK09060 690566000774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566000775 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 690566000776 active site 690566000777 Predicted permeases [General function prediction only]; Region: RarD; COG2962 690566000778 homoserine O-succinyltransferase; Provisional; Region: PRK05368 690566000779 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 690566000780 proposed active site lysine [active] 690566000781 conserved cys residue [active] 690566000782 CrcB-like protein; Region: CRCB; cl09114 690566000783 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 690566000784 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 690566000785 active site 690566000786 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 690566000787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566000788 motif II; other site 690566000789 ATP12 chaperone protein; Region: ATP12; cl02228 690566000790 L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645 690566000791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 690566000792 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 690566000793 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 690566000794 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 690566000795 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 690566000796 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 690566000797 putative active site [active] 690566000798 Zn binding site [ion binding]; other site 690566000799 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 690566000800 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 690566000801 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 690566000802 substrate binding site [chemical binding]; other site 690566000803 glutamase interaction surface [polypeptide binding]; other site 690566000804 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 690566000805 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 690566000806 catalytic residues [active] 690566000807 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 690566000808 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 690566000809 putative active site [active] 690566000810 oxyanion strand; other site 690566000811 catalytic triad [active] 690566000812 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 690566000813 putative active site pocket [active] 690566000814 4-fold oligomerization interface [polypeptide binding]; other site 690566000815 metal binding residues [ion binding]; metal-binding site 690566000816 3-fold/trimer interface [polypeptide binding]; other site 690566000817 Stringent starvation protein B; Region: SspB; pfam04386 690566000818 fumarate hydratase; Reviewed; Region: fumC; PRK00485 690566000819 Class II fumarases; Region: Fumarase_classII; cd01362 690566000820 active site 690566000821 tetramer interface [polypeptide binding]; other site 690566000822 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 690566000823 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 690566000824 catalytic site [active] 690566000825 G-X2-G-X-G-K; other site 690566000826 Uncharacterized conserved protein [Function unknown]; Region: COG1565 690566000827 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 690566000828 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 690566000829 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 690566000830 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 690566000831 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 690566000832 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 690566000833 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 690566000834 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 690566000835 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 690566000836 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 690566000837 enoyl-CoA hydratase; Provisional; Region: PRK09245 690566000838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566000839 substrate binding site [chemical binding]; other site 690566000840 oxyanion hole (OAH) forming residues; other site 690566000841 trimer interface [polypeptide binding]; other site 690566000842 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566000843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566000844 NAD(P) binding site [chemical binding]; other site 690566000845 active site 690566000846 acyl carrier protein; Provisional; Region: acpP; PRK00982 690566000847 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 690566000848 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 690566000849 dimer interface [polypeptide binding]; other site 690566000850 active site 690566000851 YceG-like family; Region: YceG; pfam02618 690566000852 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 690566000853 dimerization interface [polypeptide binding]; other site 690566000854 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 690566000855 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 690566000856 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566000857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566000858 heat shock protein 90; Provisional; Region: PRK05218 690566000859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566000860 ATP binding site [chemical binding]; other site 690566000861 Mg2+ binding site [ion binding]; other site 690566000862 G-X-G motif; other site 690566000863 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 690566000864 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 690566000865 Chromate transporter; Region: Chromate_transp; pfam02417 690566000866 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 690566000867 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 690566000868 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566000869 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566000870 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 690566000871 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 690566000872 active site 690566000873 dimer interface [polypeptide binding]; other site 690566000874 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566000875 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566000876 N-terminal plug; other site 690566000877 ligand-binding site [chemical binding]; other site 690566000878 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 690566000879 SapC; Region: SapC; pfam07277 690566000880 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 690566000881 FAD binding domain; Region: FAD_binding_4; pfam01565 690566000882 helicase 45; Provisional; Region: PTZ00424 690566000883 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 690566000884 ATP binding site [chemical binding]; other site 690566000885 Mg++ binding site [ion binding]; other site 690566000886 motif III; other site 690566000887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566000888 nucleotide binding region [chemical binding]; other site 690566000889 ATP-binding site [chemical binding]; other site 690566000890 hypothetical protein; Reviewed; Region: PRK00024 690566000891 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 690566000892 MPN+ (JAMM) motif; other site 690566000893 Zinc-binding site [ion binding]; other site 690566000894 Dicarboxylate transport; Region: DctA-YdbH; pfam11739 690566000895 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 690566000896 Protein of unknown function (DUF1318); Region: DUF1318; pfam07027 690566000897 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 690566000898 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 690566000899 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 690566000900 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 690566000901 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 690566000902 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 690566000903 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 690566000904 GIY-YIG motif/motif A; other site 690566000905 active site 690566000906 catalytic site [active] 690566000907 putative DNA binding site [nucleotide binding]; other site 690566000908 metal binding site [ion binding]; metal-binding site 690566000909 UvrB/uvrC motif; Region: UVR; pfam02151 690566000910 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 690566000911 Histidine kinase; Region: HisKA_3; pfam07730 690566000912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566000913 ATP binding site [chemical binding]; other site 690566000914 Mg2+ binding site [ion binding]; other site 690566000915 Flp/Fap pilin component; Region: Flp_Fap; cl01585 690566000916 Flp/Fap pilin component; Region: Flp_Fap; cl01585 690566000917 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 690566000918 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 690566000919 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 690566000920 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 690566000921 BON domain; Region: BON; pfam04972 690566000922 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 690566000923 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 690566000924 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 690566000925 TadE-like protein; Region: TadE; pfam07811 690566000926 AAA domain; Region: AAA_31; pfam13614 690566000927 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 690566000928 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 690566000929 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 690566000930 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566000931 ATP binding site [chemical binding]; other site 690566000932 Walker A motif; other site 690566000933 hexamer interface [polypeptide binding]; other site 690566000934 Walker B motif; other site 690566000935 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 690566000936 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566000937 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 690566000938 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566000939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566000940 TPR motif; other site 690566000941 binding surface 690566000942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566000943 binding surface 690566000944 TPR motif; other site 690566000945 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 690566000946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566000947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566000948 active site 690566000949 phosphorylation site [posttranslational modification] 690566000950 intermolecular recognition site; other site 690566000951 dimerization interface [polypeptide binding]; other site 690566000952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566000953 DNA binding residues [nucleotide binding] 690566000954 dimerization interface [polypeptide binding]; other site 690566000955 Histidine kinase; Region: HisKA_3; pfam07730 690566000956 Recombination protein O N terminal; Region: RecO_N; pfam11967 690566000957 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 690566000958 Recombination protein O C terminal; Region: RecO_C; pfam02565 690566000959 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 690566000960 tartrate dehydrogenase; Region: TTC; TIGR02089 690566000961 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 690566000962 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 690566000963 homodimer interface [polypeptide binding]; other site 690566000964 substrate-cofactor binding pocket; other site 690566000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566000966 catalytic residue [active] 690566000967 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 690566000968 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 690566000969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566000970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566000971 dimerization interface [polypeptide binding]; other site 690566000972 Tetratricopeptide repeat; Region: TPR_12; pfam13424 690566000973 Tetratricopeptide repeat; Region: TPR_10; cl17452 690566000974 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 690566000975 VCBS repeat; Region: VCBS_repeat; TIGR01965 690566000976 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 690566000977 VCBS repeat; Region: VCBS_repeat; TIGR01965 690566000978 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 690566000979 T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660 690566000980 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566000981 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 690566000982 ligand binding site [chemical binding]; other site 690566000983 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 690566000984 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 690566000985 putative active site [active] 690566000986 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 690566000987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 690566000988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566000989 Walker A/P-loop; other site 690566000990 ATP binding site [chemical binding]; other site 690566000991 Q-loop/lid; other site 690566000992 ABC transporter signature motif; other site 690566000993 Walker B; other site 690566000994 D-loop; other site 690566000995 H-loop/switch region; other site 690566000996 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 690566000997 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 690566000998 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 690566000999 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566001000 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566001001 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 690566001002 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 690566001003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566001004 ATP binding site [chemical binding]; other site 690566001005 Mg2+ binding site [ion binding]; other site 690566001006 G-X-G motif; other site 690566001007 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 690566001008 anchoring element; other site 690566001009 dimer interface [polypeptide binding]; other site 690566001010 ATP binding site [chemical binding]; other site 690566001011 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 690566001012 active site 690566001013 putative metal-binding site [ion binding]; other site 690566001014 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 690566001015 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566001016 MarR family; Region: MarR; pfam01047 690566001017 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 690566001018 GcrA cell cycle regulator; Region: GcrA; cl11564 690566001019 GcrA cell cycle regulator; Region: GcrA; cl11564 690566001020 ABC-2 type transporter; Region: ABC2_membrane; cl17235 690566001021 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 690566001022 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 690566001023 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 690566001024 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 690566001025 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 690566001026 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 690566001027 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 690566001028 active site 690566001029 homodimer interface [polypeptide binding]; other site 690566001030 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 690566001031 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 690566001032 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 690566001033 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566001034 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 690566001035 SLBB domain; Region: SLBB; pfam10531 690566001036 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 690566001037 Chain length determinant protein; Region: Wzz; pfam02706 690566001038 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 690566001039 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 690566001040 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 690566001041 putative active site [active] 690566001042 catalytic triad [active] 690566001043 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 690566001044 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566001045 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 690566001046 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 690566001047 ATP binding site [chemical binding]; other site 690566001048 active site 690566001049 substrate binding site [chemical binding]; other site 690566001050 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 690566001051 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 690566001052 active site 690566001053 homotetramer interface [polypeptide binding]; other site 690566001054 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 690566001055 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 690566001056 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 690566001057 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 690566001058 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 690566001059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566001060 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 690566001061 dimerization interface [polypeptide binding]; other site 690566001062 substrate binding pocket [chemical binding]; other site 690566001063 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 690566001064 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 690566001065 CAP-like domain; other site 690566001066 active site 690566001067 primary dimer interface [polypeptide binding]; other site 690566001068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566001069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566001070 metal binding site [ion binding]; metal-binding site 690566001071 active site 690566001072 I-site; other site 690566001073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566001074 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 690566001075 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 690566001076 active site 690566001077 NTP binding site [chemical binding]; other site 690566001078 metal binding triad [ion binding]; metal-binding site 690566001079 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 690566001080 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 690566001081 putative active site [active] 690566001082 putative CoA binding site [chemical binding]; other site 690566001083 nudix motif; other site 690566001084 metal binding site [ion binding]; metal-binding site 690566001085 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 690566001086 Dihydroneopterin aldolase; Region: FolB; pfam02152 690566001087 active site 690566001088 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 690566001089 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 690566001090 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 690566001091 EVE domain; Region: EVE; pfam01878 690566001092 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 690566001093 putative glycosyl transferase; Provisional; Region: PRK10073 690566001094 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 690566001095 active site 690566001096 recombination factor protein RarA; Reviewed; Region: PRK13342 690566001097 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001098 Walker A motif; other site 690566001099 ATP binding site [chemical binding]; other site 690566001100 Walker B motif; other site 690566001101 arginine finger; other site 690566001102 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 690566001103 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566001104 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 690566001105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 690566001106 MOSC domain; Region: MOSC; pfam03473 690566001107 3-alpha domain; Region: 3-alpha; pfam03475 690566001108 ribonuclease R; Region: RNase_R; TIGR02063 690566001109 RNB domain; Region: RNB; pfam00773 690566001110 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 690566001111 RNA binding site [nucleotide binding]; other site 690566001112 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 690566001113 cation binding site [ion binding]; other site 690566001114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 690566001115 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 690566001116 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 690566001117 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 690566001118 putative active site [active] 690566001119 putative substrate binding site [chemical binding]; other site 690566001120 putative cosubstrate binding site; other site 690566001121 catalytic site [active] 690566001122 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 690566001123 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 690566001124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566001125 binding surface 690566001126 TPR motif; other site 690566001127 Sporulation related domain; Region: SPOR; pfam05036 690566001128 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 690566001129 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566001130 P-loop; other site 690566001131 Magnesium ion binding site [ion binding]; other site 690566001132 Sporulation related domain; Region: SPOR; pfam05036 690566001133 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566001134 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566001135 N-terminal plug; other site 690566001136 ligand-binding site [chemical binding]; other site 690566001137 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 690566001138 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 690566001139 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 690566001140 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 690566001141 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 690566001142 Helix-turn-helix domain; Region: HTH_18; pfam12833 690566001143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566001144 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 690566001145 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566001146 NAD(P) binding site [chemical binding]; other site 690566001147 catalytic residues [active] 690566001148 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 690566001149 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 690566001150 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 690566001151 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566001152 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 690566001153 C-terminal domain interface [polypeptide binding]; other site 690566001154 GSH binding site (G-site) [chemical binding]; other site 690566001155 putative dimer interface [polypeptide binding]; other site 690566001156 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 690566001157 dimer interface [polypeptide binding]; other site 690566001158 N-terminal domain interface [polypeptide binding]; other site 690566001159 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 690566001160 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 690566001161 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 690566001162 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566001163 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 690566001164 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 690566001165 DNA binding residues [nucleotide binding] 690566001166 dimerization interface [polypeptide binding]; other site 690566001167 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566001168 Sulfatase; Region: Sulfatase; pfam00884 690566001169 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 690566001170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 690566001171 inhibitor-cofactor binding pocket; inhibition site 690566001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566001173 catalytic residue [active] 690566001174 succinic semialdehyde dehydrogenase; Region: PLN02278 690566001175 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 690566001176 tetramerization interface [polypeptide binding]; other site 690566001177 NAD(P) binding site [chemical binding]; other site 690566001178 catalytic residues [active] 690566001179 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 690566001180 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 690566001181 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 690566001182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566001183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566001184 active site 690566001185 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 690566001186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566001187 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566001188 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566001189 N-terminal plug; other site 690566001190 ligand-binding site [chemical binding]; other site 690566001191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566001192 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 690566001193 acyl-activating enzyme (AAE) consensus motif; other site 690566001194 AMP binding site [chemical binding]; other site 690566001195 active site 690566001196 CoA binding site [chemical binding]; other site 690566001197 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566001198 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 690566001199 NAD(P) binding site [chemical binding]; other site 690566001200 catalytic residues [active] 690566001201 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 690566001202 Amidinotransferase; Region: Amidinotransf; pfam02274 690566001203 allantoate amidohydrolase; Reviewed; Region: PRK12893 690566001204 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 690566001205 active site 690566001206 metal binding site [ion binding]; metal-binding site 690566001207 dimer interface [polypeptide binding]; other site 690566001208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566001209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566001210 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 690566001211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566001212 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566001213 dimerization interface [polypeptide binding]; other site 690566001214 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 690566001215 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566001216 NAD binding site [chemical binding]; other site 690566001217 catalytic residues [active] 690566001218 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 690566001219 O-Antigen ligase; Region: Wzy_C; pfam04932 690566001220 O-Antigen ligase; Region: Wzy_C; pfam04932 690566001221 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 690566001222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566001223 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 690566001224 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 690566001225 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 690566001226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566001227 active site 690566001228 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 690566001229 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 690566001230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566001231 active site 690566001232 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 690566001233 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 690566001234 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 690566001235 O-Antigen ligase; Region: Wzy_C; cl04850 690566001236 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 690566001237 Chain length determinant protein; Region: Wzz; cl15801 690566001238 Chain length determinant protein; Region: Wzz; cl15801 690566001239 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 690566001240 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 690566001241 Nucleotide binding site [chemical binding]; other site 690566001242 DTAP/Switch II; other site 690566001243 Switch I; other site 690566001244 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 690566001245 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566001246 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 690566001247 SLBB domain; Region: SLBB; pfam10531 690566001248 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 690566001249 putative ADP-binding pocket [chemical binding]; other site 690566001250 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566001251 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 690566001252 putative acyl transferase; Provisional; Region: PRK10191 690566001253 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 690566001254 trimer interface [polypeptide binding]; other site 690566001255 active site 690566001256 substrate binding site [chemical binding]; other site 690566001257 CoA binding site [chemical binding]; other site 690566001258 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 690566001259 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 690566001260 DXD motif; other site 690566001261 PilZ domain; Region: PilZ; pfam07238 690566001262 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 690566001263 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 690566001264 catalytic triad [active] 690566001265 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 690566001266 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566001267 putative C-terminal domain interface [polypeptide binding]; other site 690566001268 putative GSH binding site (G-site) [chemical binding]; other site 690566001269 putative dimer interface [polypeptide binding]; other site 690566001270 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 690566001271 putative N-terminal domain interface [polypeptide binding]; other site 690566001272 putative dimer interface [polypeptide binding]; other site 690566001273 putative substrate binding pocket (H-site) [chemical binding]; other site 690566001274 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 690566001275 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 690566001276 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 690566001277 Bacterial sugar transferase; Region: Bac_transf; pfam02397 690566001278 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 690566001279 active site 690566001280 tetramer interface; other site 690566001281 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 690566001282 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 690566001283 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 690566001284 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 690566001285 DNA-binding site [nucleotide binding]; DNA binding site 690566001286 RNA-binding motif; other site 690566001287 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 690566001288 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 690566001289 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 690566001290 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566001291 N-terminal plug; other site 690566001292 ligand-binding site [chemical binding]; other site 690566001293 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 690566001294 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 690566001295 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566001296 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566001297 N-terminal plug; other site 690566001298 ligand-binding site [chemical binding]; other site 690566001299 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 690566001300 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 690566001301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 690566001302 Transposase; Region: DEDD_Tnp_IS110; pfam01548 690566001303 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 690566001304 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 690566001305 ATP-NAD kinase; Region: NAD_kinase; pfam01513 690566001306 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 690566001307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566001308 FeS/SAM binding site; other site 690566001309 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 690566001310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566001311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566001312 metal binding site [ion binding]; metal-binding site 690566001313 active site 690566001314 I-site; other site 690566001315 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566001316 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 690566001317 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 690566001318 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 690566001319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566001320 ATP binding site [chemical binding]; other site 690566001321 putative Mg++ binding site [ion binding]; other site 690566001322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566001323 nucleotide binding region [chemical binding]; other site 690566001324 ATP-binding site [chemical binding]; other site 690566001325 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 690566001326 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 690566001327 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 690566001328 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 690566001329 ssDNA binding site; other site 690566001330 generic binding surface II; other site 690566001331 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566001332 ATP binding site [chemical binding]; other site 690566001333 putative Mg++ binding site [ion binding]; other site 690566001334 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566001335 nucleotide binding region [chemical binding]; other site 690566001336 ATP-binding site [chemical binding]; other site 690566001337 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 690566001338 Mechanosensitive ion channel; Region: MS_channel; pfam00924 690566001339 PilZ domain; Region: PilZ; pfam07238 690566001340 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 690566001341 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 690566001342 active site 690566001343 HIGH motif; other site 690566001344 dimer interface [polypeptide binding]; other site 690566001345 KMSKS motif; other site 690566001346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566001347 RNA binding surface [nucleotide binding]; other site 690566001348 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 690566001349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 690566001350 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 690566001351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 690566001352 dimer interface [polypeptide binding]; other site 690566001353 putative CheW interface [polypeptide binding]; other site 690566001354 Uncharacterized conserved protein [Function unknown]; Region: COG3791 690566001355 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 690566001356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001357 Walker A motif; other site 690566001358 ATP binding site [chemical binding]; other site 690566001359 Walker B motif; other site 690566001360 arginine finger; other site 690566001361 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 690566001362 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 690566001363 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 690566001364 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 690566001365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566001366 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 690566001367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566001368 DNA binding residues [nucleotide binding] 690566001369 DNA primase; Validated; Region: dnaG; PRK05667 690566001370 CHC2 zinc finger; Region: zf-CHC2; pfam01807 690566001371 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 690566001372 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 690566001373 active site 690566001374 metal binding site [ion binding]; metal-binding site 690566001375 interdomain interaction site; other site 690566001376 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 690566001377 putative active site [active] 690566001378 Yqey-like protein; Region: YqeY; pfam09424 690566001379 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 690566001380 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 690566001381 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 690566001382 catalytic site [active] 690566001383 subunit interface [polypeptide binding]; other site 690566001384 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 690566001385 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 690566001386 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 690566001387 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 690566001388 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 690566001389 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 690566001390 ATP-grasp domain; Region: ATP-grasp_4; cl17255 690566001391 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 690566001392 IMP binding site; other site 690566001393 dimer interface [polypeptide binding]; other site 690566001394 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 690566001395 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 690566001396 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 690566001397 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 690566001398 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 690566001399 enolase; Provisional; Region: eno; PRK00077 690566001400 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 690566001401 dimer interface [polypeptide binding]; other site 690566001402 metal binding site [ion binding]; metal-binding site 690566001403 substrate binding pocket [chemical binding]; other site 690566001404 Septum formation initiator; Region: DivIC; pfam04977 690566001405 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 690566001406 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566001407 tetramer interface [polypeptide binding]; other site 690566001408 TPP-binding site [chemical binding]; other site 690566001409 heterodimer interface [polypeptide binding]; other site 690566001410 phosphorylation loop region [posttranslational modification] 690566001411 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 690566001412 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566001413 E3 interaction surface; other site 690566001414 lipoyl attachment site [posttranslational modification]; other site 690566001415 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566001416 alpha subunit interface [polypeptide binding]; other site 690566001417 TPP binding site [chemical binding]; other site 690566001418 heterodimer interface [polypeptide binding]; other site 690566001419 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566001420 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 690566001421 TadE-like protein; Region: TadE; pfam07811 690566001422 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 690566001423 TadE-like protein; Region: TadE; pfam07811 690566001424 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 690566001425 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 690566001426 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 690566001427 EF-hand domain pair; Region: EF_hand_5; pfam13499 690566001428 Ca2+ binding site [ion binding]; other site 690566001429 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 690566001430 Glucose inhibited division protein A; Region: GIDA; pfam01134 690566001431 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 690566001432 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 690566001433 hypothetical protein; Provisional; Region: PRK09133 690566001434 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 690566001435 putative metal binding site [ion binding]; other site 690566001436 2-isopropylmalate synthase; Validated; Region: PRK03739 690566001437 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 690566001438 active site 690566001439 catalytic residues [active] 690566001440 metal binding site [ion binding]; metal-binding site 690566001441 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 690566001442 Uncharacterized conserved protein [Function unknown]; Region: COG2353 690566001443 ketol-acid reductoisomerase; Provisional; Region: PRK05479 690566001444 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 690566001445 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 690566001446 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 690566001447 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 690566001448 putative valine binding site [chemical binding]; other site 690566001449 dimer interface [polypeptide binding]; other site 690566001450 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 690566001451 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 690566001452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 690566001453 PYR/PP interface [polypeptide binding]; other site 690566001454 dimer interface [polypeptide binding]; other site 690566001455 TPP binding site [chemical binding]; other site 690566001456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 690566001457 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 690566001458 TPP-binding site [chemical binding]; other site 690566001459 dimer interface [polypeptide binding]; other site 690566001460 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 690566001461 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 690566001462 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 690566001463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566001464 motif II; other site 690566001465 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 690566001466 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 690566001467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566001468 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 690566001469 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 690566001470 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 690566001471 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 690566001472 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 690566001473 GatB domain; Region: GatB_Yqey; smart00845 690566001474 Peptidase family M48; Region: Peptidase_M48; cl12018 690566001475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 690566001476 TPR repeat; Region: TPR_11; pfam13414 690566001477 binding surface 690566001478 TPR motif; other site 690566001479 Autotransporter beta-domain; Region: Autotransporter; pfam03797 690566001480 Secretin and TonB N terminus short domain; Region: STN; smart00965 690566001481 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566001482 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566001483 FecR protein; Region: FecR; pfam04773 690566001484 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 690566001485 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 690566001486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566001487 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 690566001488 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 690566001489 Beta-lactamase; Region: Beta-lactamase; pfam00144 690566001490 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 690566001491 homodimer interface [polypeptide binding]; other site 690566001492 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 690566001493 active site pocket [active] 690566001494 glycogen branching enzyme; Provisional; Region: PRK05402 690566001495 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 690566001496 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 690566001497 active site 690566001498 catalytic site [active] 690566001499 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 690566001500 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 690566001501 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 690566001502 ligand binding site; other site 690566001503 oligomer interface; other site 690566001504 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 690566001505 dimer interface [polypeptide binding]; other site 690566001506 N-terminal domain interface [polypeptide binding]; other site 690566001507 sulfate 1 binding site; other site 690566001508 glycogen synthase; Provisional; Region: glgA; PRK00654 690566001509 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 690566001510 ADP-binding pocket [chemical binding]; other site 690566001511 homodimer interface [polypeptide binding]; other site 690566001512 glycogen debranching enzyme; Provisional; Region: PRK03705 690566001513 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 690566001514 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 690566001515 active site 690566001516 catalytic site [active] 690566001517 lipid-transfer protein; Provisional; Region: PRK07855 690566001518 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566001519 active site 690566001520 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 690566001521 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566001522 enoyl-CoA hydratase; Provisional; Region: PRK06688 690566001523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566001524 substrate binding site [chemical binding]; other site 690566001525 oxyanion hole (OAH) forming residues; other site 690566001526 trimer interface [polypeptide binding]; other site 690566001527 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 690566001528 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 690566001529 Trp docking motif [polypeptide binding]; other site 690566001530 active site 690566001531 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566001532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566001533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566001534 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566001535 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566001536 substrate binding site [chemical binding]; other site 690566001537 oxyanion hole (OAH) forming residues; other site 690566001538 trimer interface [polypeptide binding]; other site 690566001539 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 690566001540 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566001541 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566001542 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566001543 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566001544 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 690566001545 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566001546 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 690566001547 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 690566001548 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566001549 thiolase; Provisional; Region: PRK06158 690566001550 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566001551 active site 690566001552 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566001553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566001554 substrate binding site [chemical binding]; other site 690566001555 oxyanion hole (OAH) forming residues; other site 690566001556 trimer interface [polypeptide binding]; other site 690566001557 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566001558 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566001559 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566001560 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 690566001561 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 690566001562 Trp docking motif [polypeptide binding]; other site 690566001563 active site 690566001564 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566001565 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 690566001566 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566001567 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566001568 acyl-activating enzyme (AAE) consensus motif; other site 690566001569 acyl-activating enzyme (AAE) consensus motif; other site 690566001570 putative AMP binding site [chemical binding]; other site 690566001571 putative active site [active] 690566001572 putative CoA binding site [chemical binding]; other site 690566001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566001574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566001575 putative substrate translocation pore; other site 690566001576 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566001577 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566001578 active site 690566001579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566001580 classical (c) SDRs; Region: SDR_c; cd05233 690566001581 NAD(P) binding site [chemical binding]; other site 690566001582 active site 690566001583 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 690566001584 putative active site [active] 690566001585 putative substrate binding site [chemical binding]; other site 690566001586 ATP binding site [chemical binding]; other site 690566001587 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566001588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566001589 FO synthase; Reviewed; Region: fbiC; PRK09234 690566001590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566001591 FeS/SAM binding site; other site 690566001592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566001593 FeS/SAM binding site; other site 690566001594 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 690566001595 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 690566001596 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 690566001597 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566001598 dimer interface [polypeptide binding]; other site 690566001599 active site 690566001600 RES domain; Region: RES; pfam08808 690566001601 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 690566001602 catalytic center binding site [active] 690566001603 ATP binding site [chemical binding]; other site 690566001604 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 690566001605 Fe-S cluster binding site [ion binding]; other site 690566001606 DNA binding site [nucleotide binding] 690566001607 active site 690566001608 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 690566001609 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 690566001610 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 690566001611 putative active site; other site 690566001612 catalytic triad [active] 690566001613 putative dimer interface [polypeptide binding]; other site 690566001614 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 690566001615 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 690566001616 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 690566001617 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 690566001618 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 690566001619 PA/protease or protease-like domain interface [polypeptide binding]; other site 690566001620 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 690566001621 metal binding site [ion binding]; metal-binding site 690566001622 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 690566001623 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 690566001624 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566001625 RNA binding surface [nucleotide binding]; other site 690566001626 Chorismate mutase type II; Region: CM_2; smart00830 690566001627 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 690566001628 GIY-YIG motif/motif A; other site 690566001629 putative active site [active] 690566001630 putative metal binding site [ion binding]; other site 690566001631 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 690566001632 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 690566001633 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 690566001634 ATP cone domain; Region: ATP-cone; pfam03477 690566001635 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 690566001636 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 690566001637 dimer interface [polypeptide binding]; other site 690566001638 active site 690566001639 glycine-pyridoxal phosphate binding site [chemical binding]; other site 690566001640 folate binding site [chemical binding]; other site 690566001641 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 690566001642 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 690566001643 HPP family; Region: HPP; pfam04982 690566001644 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 690566001645 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 690566001646 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566001647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 690566001648 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 690566001649 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566001650 catalytic residue [active] 690566001651 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 690566001652 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 690566001653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566001654 catalytic residue [active] 690566001655 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 690566001656 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566001657 catalytic loop [active] 690566001658 iron binding site [ion binding]; other site 690566001659 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 690566001660 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 690566001661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001662 Walker A motif; other site 690566001663 ATP binding site [chemical binding]; other site 690566001664 Walker B motif; other site 690566001665 arginine finger; other site 690566001666 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 690566001667 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 690566001668 hypothetical protein; Validated; Region: PRK00153 690566001669 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 690566001670 Found in ATP-dependent protease La (LON); Region: LON; smart00464 690566001671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001672 Walker A motif; other site 690566001673 ATP binding site [chemical binding]; other site 690566001674 Walker B motif; other site 690566001675 arginine finger; other site 690566001676 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 690566001677 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 690566001678 IHF dimer interface [polypeptide binding]; other site 690566001679 IHF - DNA interface [nucleotide binding]; other site 690566001680 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 690566001681 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 690566001682 malic enzyme; Reviewed; Region: PRK12862 690566001683 Malic enzyme, N-terminal domain; Region: malic; pfam00390 690566001684 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 690566001685 putative NAD(P) binding site [chemical binding]; other site 690566001686 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 690566001687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566001688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566001689 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 690566001690 putative effector binding pocket; other site 690566001691 dimerization interface [polypeptide binding]; other site 690566001692 malate synthase G; Provisional; Region: PRK02999 690566001693 active site 690566001694 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 690566001695 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 690566001696 motif 1; other site 690566001697 active site 690566001698 motif 2; other site 690566001699 motif 3; other site 690566001700 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 690566001701 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 690566001702 glutaminase; Provisional; Region: PRK00971 690566001703 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 690566001704 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 690566001705 TrkA-N domain; Region: TrkA_N; pfam02254 690566001706 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 690566001707 IHF - DNA interface [nucleotide binding]; other site 690566001708 IHF dimer interface [polypeptide binding]; other site 690566001709 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 690566001710 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 690566001711 RNA binding site [nucleotide binding]; other site 690566001712 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 690566001713 RNA binding site [nucleotide binding]; other site 690566001714 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 690566001715 RNA binding site [nucleotide binding]; other site 690566001716 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 690566001717 RNA binding site [nucleotide binding]; other site 690566001718 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 690566001719 RNA binding site [nucleotide binding]; other site 690566001720 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 690566001721 RNA binding site [nucleotide binding]; other site 690566001722 cytidylate kinase; Provisional; Region: cmk; PRK00023 690566001723 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 690566001724 CMP-binding site; other site 690566001725 The sites determining sugar specificity; other site 690566001726 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 690566001727 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 690566001728 hinge; other site 690566001729 active site 690566001730 TIGR02300 family protein; Region: FYDLN_acid 690566001731 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 690566001732 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 690566001733 Family description; Region: UvrD_C_2; pfam13538 690566001734 Uncharacterized conserved protein [Function unknown]; Region: COG3791 690566001735 Transcriptional regulator; Region: Rrf2; cl17282 690566001736 Predicted transcriptional regulator [Transcription]; Region: COG1959 690566001737 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 690566001738 heme-binding site [chemical binding]; other site 690566001739 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 690566001740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 690566001741 S-adenosylmethionine binding site [chemical binding]; other site 690566001742 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 690566001743 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566001744 RNA binding surface [nucleotide binding]; other site 690566001745 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 690566001746 active site 690566001747 Response regulator receiver domain; Region: Response_reg; pfam00072 690566001748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566001749 active site 690566001750 phosphorylation site [posttranslational modification] 690566001751 intermolecular recognition site; other site 690566001752 dimerization interface [polypeptide binding]; other site 690566001753 muropeptide transporter; Reviewed; Region: ampG; PRK11902 690566001754 muropeptide transporter; Validated; Region: ampG; cl17669 690566001755 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 690566001756 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 690566001757 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 690566001758 substrate binding site [chemical binding]; other site 690566001759 active site 690566001760 catalytic residues [active] 690566001761 heterodimer interface [polypeptide binding]; other site 690566001762 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 690566001763 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 690566001764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566001765 catalytic residue [active] 690566001766 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 690566001767 active site 690566001768 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 690566001769 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 690566001770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 690566001771 putative acyl-acceptor binding pocket; other site 690566001772 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 690566001773 Repair protein; Region: Repair_PSII; pfam04536 690566001774 Protein of unknown function (DUF952); Region: DUF952; pfam06108 690566001775 DNA gyrase subunit A; Validated; Region: PRK05560 690566001776 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 690566001777 CAP-like domain; other site 690566001778 active site 690566001779 primary dimer interface [polypeptide binding]; other site 690566001780 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 690566001781 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 690566001782 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 690566001783 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 690566001784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 690566001785 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566001786 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566001787 putative DNA binding site [nucleotide binding]; other site 690566001788 putative Zn2+ binding site [ion binding]; other site 690566001789 AsnC family; Region: AsnC_trans_reg; pfam01037 690566001790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566001791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566001792 dimer interface [polypeptide binding]; other site 690566001793 phosphorylation site [posttranslational modification] 690566001794 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 690566001795 putative active site [active] 690566001796 putative catalytic site [active] 690566001797 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 690566001798 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566001799 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566001800 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566001801 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566001802 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 690566001803 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566001804 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 690566001805 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 690566001806 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 690566001807 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566001808 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566001809 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566001810 acyl-activating enzyme (AAE) consensus motif; other site 690566001811 putative AMP binding site [chemical binding]; other site 690566001812 putative active site [active] 690566001813 putative CoA binding site [chemical binding]; other site 690566001814 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 690566001815 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 690566001816 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 690566001817 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566001818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566001819 DNA-binding site [nucleotide binding]; DNA binding site 690566001820 FCD domain; Region: FCD; pfam07729 690566001821 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 690566001822 NMT1-like family; Region: NMT1_2; pfam13379 690566001823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 690566001824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 690566001825 dimer interface [polypeptide binding]; other site 690566001826 conserved gate region; other site 690566001827 putative PBP binding loops; other site 690566001828 ABC-ATPase subunit interface; other site 690566001829 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 690566001830 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 690566001831 Walker A/P-loop; other site 690566001832 ATP binding site [chemical binding]; other site 690566001833 Q-loop/lid; other site 690566001834 ABC transporter signature motif; other site 690566001835 Walker B; other site 690566001836 D-loop; other site 690566001837 H-loop/switch region; other site 690566001838 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 690566001839 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 690566001840 PA/protease or protease-like domain interface [polypeptide binding]; other site 690566001841 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 690566001842 Peptidase family M28; Region: Peptidase_M28; pfam04389 690566001843 metal binding site [ion binding]; metal-binding site 690566001844 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 690566001845 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 690566001846 Walker A/P-loop; other site 690566001847 ATP binding site [chemical binding]; other site 690566001848 Q-loop/lid; other site 690566001849 ABC transporter signature motif; other site 690566001850 Walker B; other site 690566001851 D-loop; other site 690566001852 H-loop/switch region; other site 690566001853 ABC transporter; Region: ABC_tran_2; pfam12848 690566001854 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566001855 Acylphosphatase; Region: Acylphosphatase; pfam00708 690566001856 Uncharacterized conserved protein [Function unknown]; Region: COG1432 690566001857 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 690566001858 putative metal binding site [ion binding]; other site 690566001859 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 690566001860 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 690566001861 active site clefts [active] 690566001862 zinc binding site [ion binding]; other site 690566001863 dimer interface [polypeptide binding]; other site 690566001864 lipoyl synthase; Provisional; Region: PRK05481 690566001865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566001866 FeS/SAM binding site; other site 690566001867 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 690566001868 putative coenzyme Q binding site [chemical binding]; other site 690566001869 Competence-damaged protein; Region: CinA; pfam02464 690566001870 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 690566001871 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 690566001872 substrate binding site; other site 690566001873 dimer interface; other site 690566001874 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 690566001875 homotrimer interaction site [polypeptide binding]; other site 690566001876 zinc binding site [ion binding]; other site 690566001877 CDP-binding sites; other site 690566001878 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 690566001879 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 690566001880 FMN binding site [chemical binding]; other site 690566001881 active site 690566001882 catalytic residues [active] 690566001883 substrate binding site [chemical binding]; other site 690566001884 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 690566001885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566001886 phosphorylation site [posttranslational modification] 690566001887 dimer interface [polypeptide binding]; other site 690566001888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566001889 ATP binding site [chemical binding]; other site 690566001890 Mg2+ binding site [ion binding]; other site 690566001891 G-X-G motif; other site 690566001892 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 690566001893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566001894 active site 690566001895 phosphorylation site [posttranslational modification] 690566001896 intermolecular recognition site; other site 690566001897 dimerization interface [polypeptide binding]; other site 690566001898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001899 Walker A motif; other site 690566001900 ATP binding site [chemical binding]; other site 690566001901 Walker B motif; other site 690566001902 arginine finger; other site 690566001903 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 690566001904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 690566001905 dimerization interface [polypeptide binding]; other site 690566001906 PAS domain; Region: PAS; smart00091 690566001907 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 690566001908 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566001909 dimer interface [polypeptide binding]; other site 690566001910 phosphorylation site [posttranslational modification] 690566001911 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566001912 ATP binding site [chemical binding]; other site 690566001913 Mg2+ binding site [ion binding]; other site 690566001914 G-X-G motif; other site 690566001915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566001916 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 690566001917 active site 690566001918 phosphorylation site [posttranslational modification] 690566001919 intermolecular recognition site; other site 690566001920 dimerization interface [polypeptide binding]; other site 690566001921 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566001922 Walker A motif; other site 690566001923 ATP binding site [chemical binding]; other site 690566001924 Walker B motif; other site 690566001925 arginine finger; other site 690566001926 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 690566001927 RNA-binding protein Hfq; Provisional; Region: PRK14091 690566001928 bacterial Hfq-like; Region: Hfq; cd01716 690566001929 hexamer interface [polypeptide binding]; other site 690566001930 Sm1 motif; other site 690566001931 RNA binding site [nucleotide binding]; other site 690566001932 Sm2 motif; other site 690566001933 bacterial Hfq-like; Region: Hfq; cd01716 690566001934 hexamer interface [polypeptide binding]; other site 690566001935 Sm1 motif; other site 690566001936 RNA binding site [nucleotide binding]; other site 690566001937 Sm2 motif; other site 690566001938 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 690566001939 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 690566001940 HflX GTPase family; Region: HflX; cd01878 690566001941 G1 box; other site 690566001942 GTP/Mg2+ binding site [chemical binding]; other site 690566001943 Switch I region; other site 690566001944 G2 box; other site 690566001945 G3 box; other site 690566001946 Switch II region; other site 690566001947 G4 box; other site 690566001948 G5 box; other site 690566001949 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 690566001950 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 690566001951 homodimer interface [polypeptide binding]; other site 690566001952 metal binding site [ion binding]; metal-binding site 690566001953 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 690566001954 homodimer interface [polypeptide binding]; other site 690566001955 active site 690566001956 putative chemical substrate binding site [chemical binding]; other site 690566001957 metal binding site [ion binding]; metal-binding site 690566001958 Helix-turn-helix domain; Region: HTH_28; pfam13518 690566001959 Winged helix-turn helix; Region: HTH_29; pfam13551 690566001960 Homeodomain-like domain; Region: HTH_32; pfam13565 690566001961 Integrase core domain; Region: rve; pfam00665 690566001962 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 690566001963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566001964 putative substrate translocation pore; other site 690566001965 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 690566001966 catalytic motif [active] 690566001967 Catalytic residue [active] 690566001968 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 690566001969 putative hydrolase; Provisional; Region: PRK02113 690566001970 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 690566001971 active site 690566001972 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 690566001973 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 690566001974 active site 690566001975 HIGH motif; other site 690566001976 KMSKS motif; other site 690566001977 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 690566001978 tRNA binding surface [nucleotide binding]; other site 690566001979 anticodon binding site; other site 690566001980 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 690566001981 DNA polymerase III subunit delta'; Validated; Region: PRK08485 690566001982 thymidylate kinase; Validated; Region: tmk; PRK00698 690566001983 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 690566001984 TMP-binding site; other site 690566001985 ATP-binding site [chemical binding]; other site 690566001986 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 690566001987 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 690566001988 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 690566001989 Transglycosylase SLT domain; Region: SLT_2; pfam13406 690566001990 murein hydrolase B; Provisional; Region: PRK10760; cl17906 690566001991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566001992 TPR repeat; Region: TPR_11; pfam13414 690566001993 binding surface 690566001994 TPR motif; other site 690566001995 Protein of unknown function (DUF983); Region: DUF983; cl02211 690566001996 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 690566001997 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 690566001998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 690566001999 nucleotide binding region [chemical binding]; other site 690566002000 SEC-C motif; Region: SEC-C; pfam02810 690566002001 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 690566002002 heterotetramer interface [polypeptide binding]; other site 690566002003 active site pocket [active] 690566002004 cleavage site 690566002005 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 690566002006 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 690566002007 active site 690566002008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 690566002009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 690566002010 catalytic residues [active] 690566002011 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 690566002012 Part of AAA domain; Region: AAA_19; pfam13245 690566002013 Family description; Region: UvrD_C_2; pfam13538 690566002014 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 690566002015 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 690566002016 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 690566002017 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 690566002018 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 690566002019 Substrate binding site; other site 690566002020 metal-binding site 690566002021 Phosphotransferase enzyme family; Region: APH; pfam01636 690566002022 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 690566002023 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 690566002024 PAS fold; Region: PAS_7; pfam12860 690566002025 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 690566002026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566002027 dimer interface [polypeptide binding]; other site 690566002028 phosphorylation site [posttranslational modification] 690566002029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566002030 ATP binding site [chemical binding]; other site 690566002031 Mg2+ binding site [ion binding]; other site 690566002032 G-X-G motif; other site 690566002033 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 690566002034 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 690566002035 homotetramer interface [polypeptide binding]; other site 690566002036 ligand binding site [chemical binding]; other site 690566002037 catalytic site [active] 690566002038 NAD binding site [chemical binding]; other site 690566002039 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 690566002040 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 690566002041 catalytic triad [active] 690566002042 dimer interface [polypeptide binding]; other site 690566002043 AMP nucleosidase; Provisional; Region: PRK08292 690566002044 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 690566002045 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 690566002046 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566002047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 690566002048 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 690566002049 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 690566002050 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 690566002051 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 690566002052 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566002053 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566002054 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 690566002055 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566002056 active site 690566002057 DNA binding site [nucleotide binding] 690566002058 Int/Topo IB signature motif; other site 690566002059 Helix-turn-helix domain; Region: HTH_17; cl17695 690566002060 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 690566002061 Entericidin EcnA/B family; Region: Entericidin; cl02322 690566002062 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 690566002063 active site 690566002064 HslU subunit interaction site [polypeptide binding]; other site 690566002065 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 690566002066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566002067 Walker A motif; other site 690566002068 ATP binding site [chemical binding]; other site 690566002069 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 690566002070 Walker B motif; other site 690566002071 arginine finger; other site 690566002072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 690566002073 prolyl-tRNA synthetase; Provisional; Region: PRK08661 690566002074 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 690566002075 dimer interface [polypeptide binding]; other site 690566002076 motif 1; other site 690566002077 active site 690566002078 motif 2; other site 690566002079 motif 3; other site 690566002080 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 690566002081 anticodon binding site; other site 690566002082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 690566002083 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 690566002084 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 690566002085 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 690566002086 putative acyltransferase; Provisional; Region: PRK05790 690566002087 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566002088 dimer interface [polypeptide binding]; other site 690566002089 active site 690566002090 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 690566002091 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 690566002092 active site 690566002093 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566002094 dimer interface [polypeptide binding]; other site 690566002095 substrate binding site [chemical binding]; other site 690566002096 catalytic residues [active] 690566002097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566002098 putative substrate translocation pore; other site 690566002099 CCC1-related family of proteins; Region: CCC1_like; cl00278 690566002100 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 690566002101 dimer interface [polypeptide binding]; other site 690566002102 putative tRNA-binding site [nucleotide binding]; other site 690566002103 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 690566002104 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 690566002105 ATP-grasp domain; Region: ATP-grasp_4; cl17255 690566002106 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 690566002107 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 690566002108 carboxyltransferase (CT) interaction site; other site 690566002109 biotinylation site [posttranslational modification]; other site 690566002110 biotin synthase; Region: bioB; TIGR00433 690566002111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566002112 FeS/SAM binding site; other site 690566002113 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 690566002114 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 690566002115 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 690566002116 active site 690566002117 substrate binding site [chemical binding]; other site 690566002118 coenzyme B12 binding site [chemical binding]; other site 690566002119 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 690566002120 B12 binding site [chemical binding]; other site 690566002121 cobalt ligand [ion binding]; other site 690566002122 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566002123 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 690566002124 dimer interface [polypeptide binding]; other site 690566002125 substrate binding site [chemical binding]; other site 690566002126 metal binding site [ion binding]; metal-binding site 690566002127 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 690566002128 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 690566002129 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 690566002130 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 690566002131 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566002132 non-specific DNA binding site [nucleotide binding]; other site 690566002133 salt bridge; other site 690566002134 sequence-specific DNA binding site [nucleotide binding]; other site 690566002135 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 690566002136 Domain of unknown function (DUF955); Region: DUF955; pfam06114 690566002137 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 690566002138 Biofilm formation and stress response factor; Region: BsmA; pfam10014 690566002139 glutathione reductase; Validated; Region: PRK06116 690566002140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566002141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566002142 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 690566002143 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 690566002144 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 690566002145 active site 690566002146 dimer interface [polypeptide binding]; other site 690566002147 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 690566002148 dimer interface [polypeptide binding]; other site 690566002149 active site 690566002150 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 690566002151 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 690566002152 Catalytic site [active] 690566002153 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 690566002154 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 690566002155 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 690566002156 dimerization interface [polypeptide binding]; other site 690566002157 active site 690566002158 metal binding site [ion binding]; metal-binding site 690566002159 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 690566002160 dsRNA binding site [nucleotide binding]; other site 690566002161 GTPase Era; Reviewed; Region: era; PRK00089 690566002162 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 690566002163 G1 box; other site 690566002164 GTP/Mg2+ binding site [chemical binding]; other site 690566002165 Switch I region; other site 690566002166 G2 box; other site 690566002167 Switch II region; other site 690566002168 G3 box; other site 690566002169 G4 box; other site 690566002170 G5 box; other site 690566002171 KH domain; Region: KH_2; pfam07650 690566002172 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 690566002173 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 690566002174 active site 690566002175 interdomain interaction site; other site 690566002176 putative metal-binding site [ion binding]; other site 690566002177 nucleotide binding site [chemical binding]; other site 690566002178 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 690566002179 domain I; other site 690566002180 DNA binding groove [nucleotide binding] 690566002181 phosphate binding site [ion binding]; other site 690566002182 domain II; other site 690566002183 domain III; other site 690566002184 nucleotide binding site [chemical binding]; other site 690566002185 catalytic site [active] 690566002186 domain IV; other site 690566002187 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 690566002188 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 690566002189 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 690566002190 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 690566002191 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 690566002192 DNA protecting protein DprA; Region: dprA; TIGR00732 690566002193 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 690566002194 glutamate racemase; Provisional; Region: PRK00865 690566002195 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 690566002196 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 690566002197 substrate-cofactor binding pocket; other site 690566002198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566002199 catalytic residue [active] 690566002200 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 690566002201 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 690566002202 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 690566002203 active site 690566002204 DNA binding site [nucleotide binding] 690566002205 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 690566002206 DNA binding site [nucleotide binding] 690566002207 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 690566002208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566002209 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 690566002210 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 690566002211 dimer interface [polypeptide binding]; other site 690566002212 active site 690566002213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566002214 catalytic residues [active] 690566002215 substrate binding site [chemical binding]; other site 690566002216 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 690566002217 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566002218 catalytic residue [active] 690566002219 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 690566002220 Uncharacterized conserved protein [Function unknown]; Region: COG0062 690566002221 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 690566002222 putative substrate binding site [chemical binding]; other site 690566002223 putative ATP binding site [chemical binding]; other site 690566002224 N-formylglutamate amidohydrolase; Region: FGase; cl01522 690566002225 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 690566002226 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 690566002227 binding surface 690566002228 TPR motif; other site 690566002229 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 690566002230 hydroxyglutarate oxidase; Provisional; Region: PRK11728 690566002231 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 690566002232 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 690566002233 active site 690566002234 Fe-S cluster binding site [ion binding]; other site 690566002235 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 690566002236 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566002237 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566002238 catalytic residue [active] 690566002239 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 690566002240 MPT binding site; other site 690566002241 trimer interface [polypeptide binding]; other site 690566002242 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 690566002243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566002244 FeS/SAM binding site; other site 690566002245 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 690566002246 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 690566002247 putative active site [active] 690566002248 putative PHP Thumb interface [polypeptide binding]; other site 690566002249 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 690566002250 generic binding surface II; other site 690566002251 generic binding surface I; other site 690566002252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 690566002253 dimerization interface [polypeptide binding]; other site 690566002254 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566002255 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566002256 metal binding site [ion binding]; metal-binding site 690566002257 active site 690566002258 I-site; other site 690566002259 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 690566002260 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 690566002261 Walker A/P-loop; other site 690566002262 ATP binding site [chemical binding]; other site 690566002263 Q-loop/lid; other site 690566002264 ABC transporter signature motif; other site 690566002265 Walker B; other site 690566002266 D-loop; other site 690566002267 H-loop/switch region; other site 690566002268 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 690566002269 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 690566002270 FtsX-like permease family; Region: FtsX; pfam02687 690566002271 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 690566002272 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 690566002273 putative dimer interface [polypeptide binding]; other site 690566002274 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 690566002275 potassium uptake protein; Region: kup; TIGR00794 690566002276 TPR repeat; Region: TPR_11; pfam13414 690566002277 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 690566002278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 690566002279 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 690566002280 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 690566002281 CcmE; Region: CcmE; pfam03100 690566002282 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 690566002283 amidophosphoribosyltransferase; Provisional; Region: PRK09123 690566002284 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 690566002285 active site 690566002286 tetramer interface [polypeptide binding]; other site 690566002287 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566002288 active site 690566002289 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 690566002290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566002291 NAD(P) binding site [chemical binding]; other site 690566002292 active site 690566002293 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 690566002294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566002295 S-adenosylmethionine binding site [chemical binding]; other site 690566002296 DNA photolyase; Region: DNA_photolyase; pfam00875 690566002297 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 690566002298 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 690566002299 putative active site [active] 690566002300 Ap4A binding site [chemical binding]; other site 690566002301 nudix motif; other site 690566002302 putative metal binding site [ion binding]; other site 690566002303 Protein of unknown function, DUF481; Region: DUF481; pfam04338 690566002304 hypothetical protein; Provisional; Region: PRK07338 690566002305 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 690566002306 metal binding site [ion binding]; metal-binding site 690566002307 dimer interface [polypeptide binding]; other site 690566002308 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 690566002309 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 690566002310 succinylarginine dihydrolase; Provisional; Region: PRK13281 690566002311 cobyric acid synthase; Provisional; Region: PRK00784 690566002312 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 690566002313 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 690566002314 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 690566002315 catalytic triad [active] 690566002316 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 690566002317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 690566002318 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566002319 Walker A/P-loop; other site 690566002320 ATP binding site [chemical binding]; other site 690566002321 Q-loop/lid; other site 690566002322 ABC transporter signature motif; other site 690566002323 Walker B; other site 690566002324 D-loop; other site 690566002325 H-loop/switch region; other site 690566002326 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 690566002327 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566002328 E3 interaction surface; other site 690566002329 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566002330 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 690566002331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566002332 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 690566002333 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 690566002334 Predicted membrane protein [Function unknown]; Region: COG4267 690566002335 N-terminal Putative NodB-like catalytic domain of hypothetical proteins containing C-terminal cadherin or MopE copper binding domains; Region: CE4_cadherin_MopE_like_N; cd10934 690566002336 NodB motif; other site 690566002337 putative active site [active] 690566002338 putative catalytic site [active] 690566002339 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566002340 Ca2+ binding site [ion binding]; other site 690566002341 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566002342 Ca2+ binding site [ion binding]; other site 690566002343 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566002344 Ca2+ binding site [ion binding]; other site 690566002345 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566002346 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 690566002347 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 690566002348 Uncharacterized conserved protein [Function unknown]; Region: COG3743 690566002349 pyruvate phosphate dikinase; Provisional; Region: PRK09279 690566002350 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 690566002351 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 690566002352 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 690566002353 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 690566002354 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 690566002355 dimer interface [polypeptide binding]; other site 690566002356 motif 1; other site 690566002357 active site 690566002358 motif 2; other site 690566002359 motif 3; other site 690566002360 TraB family; Region: TraB; pfam01963 690566002361 TraB family; Region: TraB; pfam01963 690566002362 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 690566002363 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 690566002364 5S rRNA interface [nucleotide binding]; other site 690566002365 CTC domain interface [polypeptide binding]; other site 690566002366 L16 interface [polypeptide binding]; other site 690566002367 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 690566002368 putative active site [active] 690566002369 catalytic residue [active] 690566002370 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 690566002371 GTP-binding protein YchF; Reviewed; Region: PRK09601 690566002372 YchF GTPase; Region: YchF; cd01900 690566002373 G1 box; other site 690566002374 GTP/Mg2+ binding site [chemical binding]; other site 690566002375 Switch I region; other site 690566002376 G2 box; other site 690566002377 Switch II region; other site 690566002378 G3 box; other site 690566002379 G4 box; other site 690566002380 G5 box; other site 690566002381 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 690566002382 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 690566002383 putative active site [active] 690566002384 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 690566002385 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 690566002386 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 690566002387 putative active site [active] 690566002388 putative catalytic site [active] 690566002389 Phage tail protein; Region: Sipho_tail; cl17486 690566002390 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 690566002391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566002392 ATP binding site [chemical binding]; other site 690566002393 Mg2+ binding site [ion binding]; other site 690566002394 G-X-G motif; other site 690566002395 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 690566002396 ATP binding site [chemical binding]; other site 690566002397 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 690566002398 rod shape-determining protein MreB; Provisional; Region: PRK13927 690566002399 MreB and similar proteins; Region: MreB_like; cd10225 690566002400 nucleotide binding site [chemical binding]; other site 690566002401 Mg binding site [ion binding]; other site 690566002402 putative protofilament interaction site [polypeptide binding]; other site 690566002403 RodZ interaction site [polypeptide binding]; other site 690566002404 rod shape-determining protein MreC; Provisional; Region: PRK13922 690566002405 rod shape-determining protein MreC; Region: MreC; pfam04085 690566002406 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 690566002407 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 690566002408 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 690566002409 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 690566002410 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 690566002411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566002412 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 690566002413 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 690566002414 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566002415 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566002416 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 690566002417 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 690566002418 Walker A/P-loop; other site 690566002419 ATP binding site [chemical binding]; other site 690566002420 Q-loop/lid; other site 690566002421 ABC transporter signature motif; other site 690566002422 Walker B; other site 690566002423 D-loop; other site 690566002424 H-loop/switch region; other site 690566002425 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 690566002426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 690566002427 Walker A/P-loop; other site 690566002428 ATP binding site [chemical binding]; other site 690566002429 Q-loop/lid; other site 690566002430 ABC transporter signature motif; other site 690566002431 Walker B; other site 690566002432 D-loop; other site 690566002433 H-loop/switch region; other site 690566002434 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 690566002435 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 690566002436 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 690566002437 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 690566002438 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566002439 MobA/MobL family; Region: MobA_MobL; pfam03389 690566002440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566002441 non-specific DNA binding site [nucleotide binding]; other site 690566002442 salt bridge; other site 690566002443 sequence-specific DNA binding site [nucleotide binding]; other site 690566002444 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 690566002445 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 690566002446 dimerization domain [polypeptide binding]; other site 690566002447 dimer interface [polypeptide binding]; other site 690566002448 catalytic residues [active] 690566002449 TraE protein; Region: TraE; cl05060 690566002450 TraK protein; Region: TraK; pfam06586 690566002451 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 690566002452 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 690566002453 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 690566002454 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 690566002455 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 690566002456 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 690566002457 TraU protein; Region: TraU; pfam06834 690566002458 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876 690566002459 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 690566002460 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 690566002461 conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771 690566002462 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 690566002463 F plasmid transfer operon protein; Region: TraF; pfam13728 690566002464 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 690566002465 catalytic residues [active] 690566002466 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 690566002467 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 690566002468 two-component response regulator; Provisional; Region: PRK09191 690566002469 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 690566002470 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 690566002471 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 690566002472 Autoinducer binding domain; Region: Autoind_bind; pfam03472 690566002473 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566002474 DNA binding residues [nucleotide binding] 690566002475 dimerization interface [polypeptide binding]; other site 690566002476 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 690566002477 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 690566002478 catalytic Zn binding site [ion binding]; other site 690566002479 structural Zn binding site [ion binding]; other site 690566002480 NAD(P) binding site [chemical binding]; other site 690566002481 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 690566002482 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 690566002483 Ligand Binding Site [chemical binding]; other site 690566002484 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 690566002485 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 690566002486 putative NAD(P) binding site [chemical binding]; other site 690566002487 putative substrate binding site [chemical binding]; other site 690566002488 catalytic Zn binding site [ion binding]; other site 690566002489 structural Zn binding site [ion binding]; other site 690566002490 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 690566002491 heme-binding site [chemical binding]; other site 690566002492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566002493 Response regulator receiver domain; Region: Response_reg; pfam00072 690566002494 active site 690566002495 phosphorylation site [posttranslational modification] 690566002496 intermolecular recognition site; other site 690566002497 dimerization interface [polypeptide binding]; other site 690566002498 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 690566002499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566002500 active site 690566002501 phosphorylation site [posttranslational modification] 690566002502 intermolecular recognition site; other site 690566002503 dimerization interface [polypeptide binding]; other site 690566002504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566002505 DNA binding residues [nucleotide binding] 690566002506 dimerization interface [polypeptide binding]; other site 690566002507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566002508 PAS domain; Region: PAS_9; pfam13426 690566002509 putative active site [active] 690566002510 heme pocket [chemical binding]; other site 690566002511 PAS domain S-box; Region: sensory_box; TIGR00229 690566002512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566002513 putative active site [active] 690566002514 heme pocket [chemical binding]; other site 690566002515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566002516 dimer interface [polypeptide binding]; other site 690566002517 phosphorylation site [posttranslational modification] 690566002518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566002519 ATP binding site [chemical binding]; other site 690566002520 Mg2+ binding site [ion binding]; other site 690566002521 G-X-G motif; other site 690566002522 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 690566002523 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 690566002524 putative dimer interface [polypeptide binding]; other site 690566002525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 690566002526 Predicted kinase [General function prediction only]; Region: COG0645 690566002527 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 690566002528 active site 690566002529 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 690566002530 active site 690566002531 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 690566002532 Putative glucoamylase; Region: Glycoamylase; pfam10091 690566002533 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 690566002534 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 690566002535 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 690566002536 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 690566002537 Ligand Binding Site [chemical binding]; other site 690566002538 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 690566002539 Ligand Binding Site [chemical binding]; other site 690566002540 phosphoenolpyruvate synthase; Validated; Region: PRK06464 690566002541 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 690566002542 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 690566002543 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 690566002544 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566002545 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566002546 Restriction endonuclease; Region: Mrr_cat; pfam04471 690566002547 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 690566002548 TrwC relaxase; Region: TrwC; pfam08751 690566002549 AAA domain; Region: AAA_30; pfam13604 690566002550 Family description; Region: UvrD_C_2; pfam13538 690566002551 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566002552 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 690566002553 Walker A motif; other site 690566002554 ATP binding site [chemical binding]; other site 690566002555 Walker B motif; other site 690566002556 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 690566002557 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 690566002558 Protein of unknown function (DUF736); Region: DUF736; pfam05284 690566002559 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 690566002560 oligomeric interface; other site 690566002561 putative active site [active] 690566002562 homodimer interface [polypeptide binding]; other site 690566002563 prevent-host-death family protein; Region: phd_fam; TIGR01552 690566002564 PIN domain; Region: PIN_3; cl17397 690566002565 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 690566002566 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 690566002567 Protein of unknown function (DUF1419); Region: DUF1419; pfam07215 690566002568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566002569 ATP binding site [chemical binding]; other site 690566002570 Mg2+ binding site [ion binding]; other site 690566002571 G-X-G motif; other site 690566002572 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 690566002573 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 690566002574 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 690566002575 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 690566002576 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 690566002577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566002578 S-adenosylmethionine binding site [chemical binding]; other site 690566002579 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 690566002580 DEAD-like helicases superfamily; Region: DEXDc; smart00487 690566002581 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 690566002582 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 690566002583 helicase superfamily c-terminal domain; Region: HELICc; smart00490 690566002584 nucleotide binding region [chemical binding]; other site 690566002585 ATP-binding site [chemical binding]; other site 690566002586 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 690566002587 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 690566002588 ATP binding site [chemical binding]; other site 690566002589 PRTRC system protein A; Region: PRTRC_A; TIGR03735 690566002590 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 690566002591 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 690566002592 Alpha-helical domain 2; Region: alpha-hel2; pfam14456 690566002593 Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020 690566002594 PRTRC system protein E; Region: PRTRC_E; TIGR03741 690566002595 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566002596 ParB-like nuclease domain; Region: ParB; smart00470 690566002597 Toprim domain; Region: Toprim_3; pfam13362 690566002598 active site 690566002599 metal binding site [ion binding]; metal-binding site 690566002600 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 690566002601 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 690566002602 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566002603 active site 690566002604 DNA binding site [nucleotide binding] 690566002605 Int/Topo IB signature motif; other site 690566002606 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566002607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566002608 putative DNA binding site [nucleotide binding]; other site 690566002609 putative Zn2+ binding site [ion binding]; other site 690566002610 AsnC family; Region: AsnC_trans_reg; pfam01037 690566002611 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 690566002612 Bacterial sugar transferase; Region: Bac_transf; pfam02397 690566002613 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 690566002614 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 690566002615 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566002616 SLBB domain; Region: SLBB; pfam10531 690566002617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566002618 AAA domain; Region: AAA_22; pfam13401 690566002619 Walker A motif; other site 690566002620 ATP binding site [chemical binding]; other site 690566002621 Walker B motif; other site 690566002622 arginine finger; other site 690566002623 chain length determinant protein EpsF; Region: EpsF; TIGR03017 690566002624 Chain length determinant protein; Region: Wzz; pfam02706 690566002625 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 690566002626 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 690566002627 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 690566002628 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 690566002629 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 690566002630 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 690566002631 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 690566002632 O-Antigen ligase; Region: Wzy_C; pfam04932 690566002633 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 690566002634 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566002635 active site 690566002636 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 690566002637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 690566002638 active site 690566002639 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 690566002640 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 690566002641 active site 690566002642 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566002643 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 690566002644 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 690566002645 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 690566002646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566002647 active site 690566002648 Calx-beta domain; Region: Calx-beta; cl02522 690566002649 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 690566002650 active site 690566002651 catalytic residues [active] 690566002652 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 690566002653 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 690566002654 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 690566002655 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 690566002656 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566002657 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566002658 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566002659 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566002660 D-galactonate transporter; Region: 2A0114; TIGR00893 690566002661 putative substrate translocation pore; other site 690566002662 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 690566002663 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566002664 NAD(P) binding site [chemical binding]; other site 690566002665 catalytic residues [active] 690566002666 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 690566002667 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 690566002668 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566002669 Cytochrome P450; Region: p450; cl12078 690566002670 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566002671 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566002672 active site 690566002673 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566002674 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566002675 active site 690566002676 Prostaglandin dehydrogenases; Region: PGDH; cd05288 690566002677 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 690566002678 NAD(P) binding site [chemical binding]; other site 690566002679 substrate binding site [chemical binding]; other site 690566002680 dimer interface [polypeptide binding]; other site 690566002681 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 690566002682 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566002683 Uncharacterized conserved protein [Function unknown]; Region: COG3777 690566002684 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 690566002685 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 690566002686 active site 2 [active] 690566002687 active site 1 [active] 690566002688 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566002689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566002690 active site 690566002691 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 690566002692 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566002693 dimer interface [polypeptide binding]; other site 690566002694 active site 690566002695 Cytochrome c2 [Energy production and conversion]; Region: COG3474 690566002696 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566002697 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566002698 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566002699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566002700 NAD(P) binding site [chemical binding]; other site 690566002701 active site 690566002702 enoyl-CoA hydratase; Provisional; Region: PRK08290 690566002703 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566002704 substrate binding site [chemical binding]; other site 690566002705 oxyanion hole (OAH) forming residues; other site 690566002706 trimer interface [polypeptide binding]; other site 690566002707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566002708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566002709 active site 690566002710 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 690566002711 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 690566002712 putative MPT binding site; other site 690566002713 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 690566002714 active site 690566002715 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 690566002716 Nitrogen regulatory protein P-II; Region: P-II; smart00938 690566002717 glutamine synthetase; Provisional; Region: glnA; PRK09469 690566002718 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 690566002719 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 690566002720 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566002721 FMN binding site [chemical binding]; other site 690566002722 substrate binding site [chemical binding]; other site 690566002723 putative catalytic residue [active] 690566002724 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 690566002725 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 690566002726 MPN+ (JAMM) motif; other site 690566002727 Zinc-binding site [ion binding]; other site 690566002728 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 690566002729 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566002730 RNA binding surface [nucleotide binding]; other site 690566002731 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 690566002732 active site 690566002733 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 690566002734 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 690566002735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566002736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566002737 DNA binding residues [nucleotide binding] 690566002738 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 690566002739 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 690566002740 Transglycosylase; Region: Transgly; cl17702 690566002741 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 690566002742 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 690566002743 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566002744 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 690566002745 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 690566002746 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566002747 Walker A motif; other site 690566002748 ATP binding site [chemical binding]; other site 690566002749 Walker B motif; other site 690566002750 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 690566002751 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 690566002752 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 690566002753 oligomer interface [polypeptide binding]; other site 690566002754 active site residues [active] 690566002755 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 690566002756 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 690566002757 Ligand binding site; other site 690566002758 Putative Catalytic site; other site 690566002759 DXD motif; other site 690566002760 trigger factor; Provisional; Region: tig; PRK01490 690566002761 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 690566002762 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 690566002763 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 690566002764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566002765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566002766 DNA binding residues [nucleotide binding] 690566002767 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 690566002768 FecR protein; Region: FecR; pfam04773 690566002769 NAD-dependent deacetylase; Provisional; Region: PRK00481 690566002770 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 690566002771 NAD+ binding site [chemical binding]; other site 690566002772 substrate binding site [chemical binding]; other site 690566002773 Zn binding site [ion binding]; other site 690566002774 dihydrodipicolinate reductase; Provisional; Region: PRK00048 690566002775 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 690566002776 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 690566002777 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 690566002778 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 690566002779 minor groove reading motif; other site 690566002780 helix-hairpin-helix signature motif; other site 690566002781 substrate binding pocket [chemical binding]; other site 690566002782 active site 690566002783 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 690566002784 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 690566002785 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 690566002786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 690566002787 Soluble P-type ATPase [General function prediction only]; Region: COG4087 690566002788 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 690566002789 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 690566002790 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 690566002791 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 690566002792 Ligand Binding Site [chemical binding]; other site 690566002793 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 690566002794 GAF domain; Region: GAF_3; pfam13492 690566002795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566002796 dimer interface [polypeptide binding]; other site 690566002797 phosphorylation site [posttranslational modification] 690566002798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566002799 ATP binding site [chemical binding]; other site 690566002800 Mg2+ binding site [ion binding]; other site 690566002801 G-X-G motif; other site 690566002802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566002803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566002804 active site 690566002805 phosphorylation site [posttranslational modification] 690566002806 intermolecular recognition site; other site 690566002807 dimerization interface [polypeptide binding]; other site 690566002808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566002809 DNA binding site [nucleotide binding] 690566002810 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 690566002811 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 690566002812 active site 690566002813 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566002814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566002815 DNA-binding site [nucleotide binding]; DNA binding site 690566002816 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 690566002817 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 690566002818 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 690566002819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566002820 NAD(P) binding site [chemical binding]; other site 690566002821 catalytic residues [active] 690566002822 choline dehydrogenase; Validated; Region: PRK02106 690566002823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566002824 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566002825 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566002826 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 690566002827 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566002828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566002829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566002830 putative substrate translocation pore; other site 690566002831 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566002832 active site 690566002833 metal binding site [ion binding]; metal-binding site 690566002834 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566002835 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566002836 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566002837 N-terminal plug; other site 690566002838 ligand-binding site [chemical binding]; other site 690566002839 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 690566002840 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 690566002841 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 690566002842 DNA binding site [nucleotide binding] 690566002843 active site 690566002844 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566002845 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 690566002846 Protein export membrane protein; Region: SecD_SecF; cl14618 690566002847 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566002848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566002849 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566002850 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 690566002851 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 690566002852 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 690566002853 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 690566002854 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 690566002855 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 690566002856 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 690566002857 ATP binding site [chemical binding]; other site 690566002858 Mg++ binding site [ion binding]; other site 690566002859 motif III; other site 690566002860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566002861 nucleotide binding region [chemical binding]; other site 690566002862 ATP-binding site [chemical binding]; other site 690566002863 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 690566002864 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 690566002865 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 690566002866 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 690566002867 Glycoprotease family; Region: Peptidase_M22; pfam00814 690566002868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566002869 Coenzyme A binding pocket [chemical binding]; other site 690566002870 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 690566002871 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 690566002872 metal binding site 2 [ion binding]; metal-binding site 690566002873 putative DNA binding helix; other site 690566002874 metal binding site 1 [ion binding]; metal-binding site 690566002875 dimer interface [polypeptide binding]; other site 690566002876 structural Zn2+ binding site [ion binding]; other site 690566002877 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 690566002878 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 690566002879 putative acyl-acceptor binding pocket; other site 690566002880 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 690566002881 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 690566002882 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566002883 FeS/SAM binding site; other site 690566002884 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 690566002885 PhoH-like protein; Region: PhoH; pfam02562 690566002886 metal-binding heat shock protein; Provisional; Region: PRK00016 690566002887 FOG: CBS domain [General function prediction only]; Region: COG0517 690566002888 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 690566002889 Transporter associated domain; Region: CorC_HlyC; smart01091 690566002890 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 690566002891 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 690566002892 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 690566002893 active site 690566002894 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 690566002895 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566002896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566002897 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 690566002898 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 690566002899 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566002900 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 690566002901 E3 interaction surface; other site 690566002902 lipoyl attachment site [posttranslational modification]; other site 690566002903 e3 binding domain; Region: E3_binding; pfam02817 690566002904 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566002905 ABC-2 type transporter; Region: ABC2_membrane; cl17235 690566002906 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 690566002907 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 690566002908 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 690566002909 Walker A/P-loop; other site 690566002910 ATP binding site [chemical binding]; other site 690566002911 Q-loop/lid; other site 690566002912 ABC transporter signature motif; other site 690566002913 Walker B; other site 690566002914 D-loop; other site 690566002915 H-loop/switch region; other site 690566002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566002917 S-adenosylmethionine binding site [chemical binding]; other site 690566002918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566002919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566002920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566002921 dimerization interface [polypeptide binding]; other site 690566002922 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566002923 Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162 690566002924 substrate binding pocket [chemical binding]; other site 690566002925 FAD binding site [chemical binding]; other site 690566002926 catalytic base [active] 690566002927 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 690566002928 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566002929 substrate binding site [chemical binding]; other site 690566002930 oxyanion hole (OAH) forming residues; other site 690566002931 trimer interface [polypeptide binding]; other site 690566002932 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 690566002933 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 690566002934 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 690566002935 enoyl-CoA hydratase; Provisional; Region: PRK05862 690566002936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566002937 substrate binding site [chemical binding]; other site 690566002938 oxyanion hole (OAH) forming residues; other site 690566002939 trimer interface [polypeptide binding]; other site 690566002940 short chain dehydrogenase; Provisional; Region: PRK09134 690566002941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566002942 NAD(P) binding site [chemical binding]; other site 690566002943 active site 690566002944 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 690566002945 GTP cyclohydrolase I; Provisional; Region: PLN03044 690566002946 active site 690566002947 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 690566002948 Ligand binding site; other site 690566002949 metal-binding site 690566002950 Transmembrane secretion effector; Region: MFS_3; pfam05977 690566002951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566002952 putative substrate translocation pore; other site 690566002953 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 690566002954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566002955 dimer interface [polypeptide binding]; other site 690566002956 active site 690566002957 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566002958 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566002959 substrate binding site [chemical binding]; other site 690566002960 oxyanion hole (OAH) forming residues; other site 690566002961 trimer interface [polypeptide binding]; other site 690566002962 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566002963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566002964 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566002965 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 690566002966 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 690566002967 NAD binding site [chemical binding]; other site 690566002968 homodimer interface [polypeptide binding]; other site 690566002969 active site 690566002970 substrate binding site [chemical binding]; other site 690566002971 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 690566002972 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 690566002973 putative active site [active] 690566002974 aspartate aminotransferase; Provisional; Region: PRK05764 690566002975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566002976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566002977 homodimer interface [polypeptide binding]; other site 690566002978 catalytic residue [active] 690566002979 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566002980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566002981 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 690566002982 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 690566002983 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 690566002984 phosphogluconate dehydratase; Validated; Region: PRK09054 690566002985 6-phosphogluconate dehydratase; Region: edd; TIGR01196 690566002986 Glucokinase; Region: Glucokinase; pfam02685 690566002987 glucokinase, proteobacterial type; Region: glk; TIGR00749 690566002988 Entner-Doudoroff aldolase; Region: eda; TIGR01182 690566002989 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 690566002990 active site 690566002991 intersubunit interface [polypeptide binding]; other site 690566002992 catalytic residue [active] 690566002993 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 690566002994 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 690566002995 trimer interface [polypeptide binding]; other site 690566002996 putative metal binding site [ion binding]; other site 690566002997 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 690566002998 dimer interface [polypeptide binding]; other site 690566002999 allosteric magnesium binding site [ion binding]; other site 690566003000 active site 690566003001 aspartate-rich active site metal binding site; other site 690566003002 Schiff base residues; other site 690566003003 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 690566003004 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 690566003005 PA/protease or protease-like domain interface [polypeptide binding]; other site 690566003006 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 690566003007 Peptidase family M28; Region: Peptidase_M28; pfam04389 690566003008 metal binding site [ion binding]; metal-binding site 690566003009 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 690566003010 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 690566003011 metabolite-proton symporter; Region: 2A0106; TIGR00883 690566003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566003013 putative substrate translocation pore; other site 690566003014 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 690566003015 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 690566003016 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 690566003017 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 690566003018 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 690566003019 D-pathway; other site 690566003020 Putative ubiquinol binding site [chemical binding]; other site 690566003021 Low-spin heme (heme b) binding site [chemical binding]; other site 690566003022 Putative water exit pathway; other site 690566003023 Binuclear center (heme o3/CuB) [ion binding]; other site 690566003024 K-pathway; other site 690566003025 Putative proton exit pathway; other site 690566003026 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 690566003027 Subunit I/III interface [polypeptide binding]; other site 690566003028 Subunit III/IV interface [polypeptide binding]; other site 690566003029 Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125 690566003030 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 690566003031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566003032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003033 ATP binding site [chemical binding]; other site 690566003034 Mg2+ binding site [ion binding]; other site 690566003035 G-X-G motif; other site 690566003036 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 690566003037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003038 active site 690566003039 phosphorylation site [posttranslational modification] 690566003040 intermolecular recognition site; other site 690566003041 dimerization interface [polypeptide binding]; other site 690566003042 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 690566003043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566003044 PAS domain; Region: PAS_9; pfam13426 690566003045 putative active site [active] 690566003046 heme pocket [chemical binding]; other site 690566003047 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566003048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566003049 dimer interface [polypeptide binding]; other site 690566003050 phosphorylation site [posttranslational modification] 690566003051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003052 ATP binding site [chemical binding]; other site 690566003053 Mg2+ binding site [ion binding]; other site 690566003054 G-X-G motif; other site 690566003055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566003056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003057 active site 690566003058 phosphorylation site [posttranslational modification] 690566003059 intermolecular recognition site; other site 690566003060 dimerization interface [polypeptide binding]; other site 690566003061 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566003062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 690566003063 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 690566003064 catalytic site [active] 690566003065 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 690566003066 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566003067 FMN binding site [chemical binding]; other site 690566003068 substrate binding site [chemical binding]; other site 690566003069 putative catalytic residue [active] 690566003070 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 690566003071 serine O-acetyltransferase; Region: cysE; TIGR01172 690566003072 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 690566003073 trimer interface [polypeptide binding]; other site 690566003074 active site 690566003075 substrate binding site [chemical binding]; other site 690566003076 CoA binding site [chemical binding]; other site 690566003077 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566003078 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566003079 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566003080 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 690566003081 dimerization interface [polypeptide binding]; other site 690566003082 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 690566003083 MoaE homodimer interface [polypeptide binding]; other site 690566003084 MoaD interaction [polypeptide binding]; other site 690566003085 active site residues [active] 690566003086 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 690566003087 MoaE interaction surface [polypeptide binding]; other site 690566003088 MoeB interaction surface [polypeptide binding]; other site 690566003089 thiocarboxylated glycine; other site 690566003090 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 690566003091 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 690566003092 Transglycosylase; Region: Transgly; pfam00912 690566003093 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 690566003094 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 690566003095 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 690566003096 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 690566003097 trimerization site [polypeptide binding]; other site 690566003098 active site 690566003099 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 690566003100 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 690566003101 TrkA-N domain; Region: TrkA_N; pfam02254 690566003102 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 690566003103 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 690566003104 metal binding site 2 [ion binding]; metal-binding site 690566003105 putative DNA binding helix; other site 690566003106 metal binding site 1 [ion binding]; metal-binding site 690566003107 dimer interface [polypeptide binding]; other site 690566003108 structural Zn2+ binding site [ion binding]; other site 690566003109 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 690566003110 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 690566003111 TPP-binding site; other site 690566003112 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 690566003113 PYR/PP interface [polypeptide binding]; other site 690566003114 dimer interface [polypeptide binding]; other site 690566003115 TPP binding site [chemical binding]; other site 690566003116 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566003117 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 690566003118 putative hydrophobic ligand binding site [chemical binding]; other site 690566003119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566003120 dimerization interface [polypeptide binding]; other site 690566003121 putative DNA binding site [nucleotide binding]; other site 690566003122 putative Zn2+ binding site [ion binding]; other site 690566003123 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 690566003124 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 690566003125 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 690566003126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566003127 active site 690566003128 HIGH motif; other site 690566003129 nucleotide binding site [chemical binding]; other site 690566003130 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 690566003131 active site 690566003132 KMSKS motif; other site 690566003133 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 690566003134 tRNA binding surface [nucleotide binding]; other site 690566003135 anticodon binding site; other site 690566003136 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 690566003137 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 690566003138 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 690566003139 active site 690566003140 Riboflavin kinase; Region: Flavokinase; smart00904 690566003141 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 690566003142 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 690566003143 folate binding site [chemical binding]; other site 690566003144 NADP+ binding site [chemical binding]; other site 690566003145 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 690566003146 ATP-grasp domain; Region: ATP-grasp; pfam02222 690566003147 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 690566003148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 690566003149 catalytic core [active] 690566003150 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 690566003151 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 690566003152 tandem repeat interface [polypeptide binding]; other site 690566003153 oligomer interface [polypeptide binding]; other site 690566003154 active site residues [active] 690566003155 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 690566003156 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 690566003157 tandem repeat interface [polypeptide binding]; other site 690566003158 oligomer interface [polypeptide binding]; other site 690566003159 active site residues [active] 690566003160 Predicted membrane protein [Function unknown]; Region: COG2860 690566003161 UPF0126 domain; Region: UPF0126; pfam03458 690566003162 UPF0126 domain; Region: UPF0126; pfam03458 690566003163 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 690566003164 catalytic residues [active] 690566003165 dimer interface [polypeptide binding]; other site 690566003166 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 690566003167 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 690566003168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566003169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566003170 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 690566003171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566003172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003173 active site 690566003174 phosphorylation site [posttranslational modification] 690566003175 intermolecular recognition site; other site 690566003176 dimerization interface [polypeptide binding]; other site 690566003177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566003178 DNA binding site [nucleotide binding] 690566003179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566003180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003181 ATP binding site [chemical binding]; other site 690566003182 Mg2+ binding site [ion binding]; other site 690566003183 G-X-G motif; other site 690566003184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 690566003185 aconitate hydratase; Validated; Region: PRK09277 690566003186 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 690566003187 substrate binding site [chemical binding]; other site 690566003188 ligand binding site [chemical binding]; other site 690566003189 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 690566003190 substrate binding site [chemical binding]; other site 690566003191 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 690566003192 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 690566003193 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 690566003194 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 690566003195 Multicopper oxidase; Region: Cu-oxidase; pfam00394 690566003196 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 690566003197 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 690566003198 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 690566003199 dimerization interface [polypeptide binding]; other site 690566003200 ligand binding site [chemical binding]; other site 690566003201 NADP binding site [chemical binding]; other site 690566003202 catalytic site [active] 690566003203 Bacterial SH3 domain; Region: SH3_4; pfam06347 690566003204 Bacterial SH3 domain; Region: SH3_4; pfam06347 690566003205 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 690566003206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566003207 putative substrate translocation pore; other site 690566003208 POT family; Region: PTR2; cl17359 690566003209 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 690566003210 putative FMN binding site [chemical binding]; other site 690566003211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566003212 DNA-binding site [nucleotide binding]; DNA binding site 690566003213 PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915 690566003214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003215 active site 690566003216 phosphorylation site [posttranslational modification] 690566003217 intermolecular recognition site; other site 690566003218 dimerization interface [polypeptide binding]; other site 690566003219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566003220 Walker A motif; other site 690566003221 ATP binding site [chemical binding]; other site 690566003222 Walker B motif; other site 690566003223 arginine finger; other site 690566003224 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 690566003225 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 690566003226 GAF domain; Region: GAF_3; pfam13492 690566003227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003228 ATP binding site [chemical binding]; other site 690566003229 Mg2+ binding site [ion binding]; other site 690566003230 G-X-G motif; other site 690566003231 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 690566003232 Bacterial sugar transferase; Region: Bac_transf; pfam02397 690566003233 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 690566003234 RNA polymerase sigma factor; Provisional; Region: PRK12547 690566003235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566003236 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 690566003237 DNA binding residues [nucleotide binding] 690566003238 two-component response regulator; Provisional; Region: PRK09191 690566003239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003240 active site 690566003241 phosphorylation site [posttranslational modification] 690566003242 intermolecular recognition site; other site 690566003243 dimerization interface [polypeptide binding]; other site 690566003244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 690566003245 Histidine kinase; Region: HisKA_2; pfam07568 690566003246 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 690566003247 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 690566003248 enoyl-CoA hydratase; Validated; Region: PRK08788 690566003249 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566003250 substrate binding site [chemical binding]; other site 690566003251 oxyanion hole (OAH) forming residues; other site 690566003252 trimer interface [polypeptide binding]; other site 690566003253 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566003254 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566003255 metal binding site [ion binding]; metal-binding site 690566003256 active site 690566003257 I-site; other site 690566003258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566003259 Predicted acetyltransferase [General function prediction only]; Region: COG3393 690566003260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566003261 Coenzyme A binding pocket [chemical binding]; other site 690566003262 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 690566003263 conserved hypothetical protein; Region: MG423; TIGR00649 690566003264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 690566003265 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 690566003266 pantothenate kinase; Reviewed; Region: PRK13318 690566003267 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 690566003268 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 690566003269 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 690566003270 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 690566003271 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 690566003272 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 690566003273 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 690566003274 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 690566003275 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 690566003276 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 690566003277 NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455 690566003278 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 690566003279 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 690566003280 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 690566003281 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 690566003282 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 690566003283 4Fe-4S binding domain; Region: Fer4; pfam00037 690566003284 4Fe-4S binding domain; Region: Fer4; pfam00037 690566003285 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 690566003286 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 690566003287 NADH dehydrogenase subunit G; Validated; Region: PRK09130 690566003288 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566003289 catalytic loop [active] 690566003290 iron binding site [ion binding]; other site 690566003291 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 690566003292 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 690566003293 molybdopterin cofactor binding site; other site 690566003294 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 690566003295 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 690566003296 SLBB domain; Region: SLBB; pfam10531 690566003297 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 690566003298 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 690566003299 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 690566003300 putative dimer interface [polypeptide binding]; other site 690566003301 [2Fe-2S] cluster binding site [ion binding]; other site 690566003302 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 690566003303 NADH dehydrogenase subunit D; Validated; Region: PRK06075 690566003304 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 690566003305 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 690566003306 NADH dehydrogenase subunit B; Validated; Region: PRK06411 690566003307 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 690566003308 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 690566003309 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 690566003310 active site 690566003311 dimerization interface [polypeptide binding]; other site 690566003312 elongation factor P; Validated; Region: PRK00529 690566003313 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 690566003314 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 690566003315 RNA binding site [nucleotide binding]; other site 690566003316 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 690566003317 RNA binding site [nucleotide binding]; other site 690566003318 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566003319 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566003320 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 690566003321 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 690566003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 690566003323 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 690566003324 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 690566003325 thiamine phosphate binding site [chemical binding]; other site 690566003326 active site 690566003327 pyrophosphate binding site [ion binding]; other site 690566003328 Protein of unknown function DUF72; Region: DUF72; pfam01904 690566003329 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 690566003330 catalytic residue [active] 690566003331 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 690566003332 Phosphoglycerate kinase; Region: PGK; pfam00162 690566003333 substrate binding site [chemical binding]; other site 690566003334 hinge regions; other site 690566003335 ADP binding site [chemical binding]; other site 690566003336 catalytic site [active] 690566003337 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 690566003338 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 690566003339 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 690566003340 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 690566003341 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 690566003342 TPP-binding site [chemical binding]; other site 690566003343 dimer interface [polypeptide binding]; other site 690566003344 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 690566003345 PYR/PP interface [polypeptide binding]; other site 690566003346 dimer interface [polypeptide binding]; other site 690566003347 TPP binding site [chemical binding]; other site 690566003348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566003349 Cell division protein ZapA; Region: ZapA; pfam05164 690566003350 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 690566003351 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 690566003352 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 690566003353 Domain of unknown function DUF20; Region: UPF0118; pfam01594 690566003354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 690566003355 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 690566003356 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566003357 E3 interaction surface; other site 690566003358 lipoyl attachment site [posttranslational modification]; other site 690566003359 e3 binding domain; Region: E3_binding; pfam02817 690566003360 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566003361 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 690566003362 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566003363 alpha subunit interface [polypeptide binding]; other site 690566003364 TPP binding site [chemical binding]; other site 690566003365 heterodimer interface [polypeptide binding]; other site 690566003366 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566003367 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 690566003368 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 690566003369 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566003370 tetramer interface [polypeptide binding]; other site 690566003371 TPP-binding site [chemical binding]; other site 690566003372 heterodimer interface [polypeptide binding]; other site 690566003373 phosphorylation loop region [posttranslational modification] 690566003374 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 690566003375 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 690566003376 dimerization interface [polypeptide binding]; other site 690566003377 active site 690566003378 adenylosuccinate lyase; Provisional; Region: PRK07492 690566003379 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 690566003380 tetramer interface [polypeptide binding]; other site 690566003381 active site 690566003382 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 690566003383 EF-hand domain pair; Region: EF_hand_5; pfam13499 690566003384 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 690566003385 Ca2+ binding site [ion binding]; other site 690566003386 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 690566003387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566003388 putative substrate translocation pore; other site 690566003389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566003390 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 690566003391 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 690566003392 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 690566003393 active site 690566003394 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 690566003395 hypothetical protein; Provisional; Region: PRK09256 690566003396 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 690566003397 GAF domain; Region: GAF_2; pfam13185 690566003398 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 690566003399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566003400 putative active site [active] 690566003401 PAS fold; Region: PAS_3; pfam08447 690566003402 heme pocket [chemical binding]; other site 690566003403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566003404 PAS fold; Region: PAS_3; pfam08447 690566003405 putative active site [active] 690566003406 heme pocket [chemical binding]; other site 690566003407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566003408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566003409 metal binding site [ion binding]; metal-binding site 690566003410 active site 690566003411 I-site; other site 690566003412 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566003413 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 690566003414 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 690566003415 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 690566003416 threonine dehydratase; Provisional; Region: PRK07334 690566003417 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 690566003418 tetramer interface [polypeptide binding]; other site 690566003419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566003420 catalytic residue [active] 690566003421 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 690566003422 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 690566003423 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 690566003424 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 690566003425 Amidohydrolase family; Region: Amidohydro_3; pfam07969 690566003426 active site 690566003427 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 690566003428 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566003429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 690566003430 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566003431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566003432 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 690566003433 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 690566003434 DXD motif; other site 690566003435 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 690566003436 Bacterial sugar transferase; Region: Bac_transf; pfam02397 690566003437 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 690566003438 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 690566003439 active site 690566003440 dimer interface [polypeptide binding]; other site 690566003441 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 690566003442 Ligand Binding Site [chemical binding]; other site 690566003443 Molecular Tunnel; other site 690566003444 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 690566003445 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 690566003446 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 690566003447 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 690566003448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 690566003449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 690566003450 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 690566003451 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941 690566003452 putative active site [active] 690566003453 putative catalytic site [active] 690566003454 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 690566003455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 690566003456 Walker A motif; other site 690566003457 ATP binding site [chemical binding]; other site 690566003458 Walker B motif; other site 690566003459 arginine finger; other site 690566003460 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 690566003461 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 690566003462 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 690566003463 Chain length determinant protein; Region: Wzz; pfam02706 690566003464 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566003465 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 690566003466 SLBB domain; Region: SLBB; pfam10531 690566003467 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 690566003468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 690566003469 dimer interface [polypeptide binding]; other site 690566003470 active site 690566003471 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566003472 catalytic residues [active] 690566003473 substrate binding site [chemical binding]; other site 690566003474 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 690566003475 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566003476 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566003477 acyl-activating enzyme (AAE) consensus motif; other site 690566003478 acyl-activating enzyme (AAE) consensus motif; other site 690566003479 AMP binding site [chemical binding]; other site 690566003480 active site 690566003481 CoA binding site [chemical binding]; other site 690566003482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 690566003483 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 690566003484 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 690566003485 nucleotide binding pocket [chemical binding]; other site 690566003486 K-X-D-G motif; other site 690566003487 catalytic site [active] 690566003488 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 690566003489 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 690566003490 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 690566003491 Dimer interface [polypeptide binding]; other site 690566003492 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 690566003493 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 690566003494 Walker A/P-loop; other site 690566003495 ATP binding site [chemical binding]; other site 690566003496 Q-loop/lid; other site 690566003497 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 690566003498 ABC transporter signature motif; other site 690566003499 Walker B; other site 690566003500 D-loop; other site 690566003501 H-loop/switch region; other site 690566003502 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 690566003503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 690566003504 binding surface 690566003505 TPR motif; other site 690566003506 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 690566003507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 690566003508 Histidine kinase; Region: HisKA_2; pfam07568 690566003509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003510 ATP binding site [chemical binding]; other site 690566003511 Mg2+ binding site [ion binding]; other site 690566003512 G-X-G motif; other site 690566003513 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 690566003514 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 690566003515 RNase E interface [polypeptide binding]; other site 690566003516 trimer interface [polypeptide binding]; other site 690566003517 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 690566003518 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 690566003519 RNase E interface [polypeptide binding]; other site 690566003520 trimer interface [polypeptide binding]; other site 690566003521 active site 690566003522 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 690566003523 putative nucleic acid binding region [nucleotide binding]; other site 690566003524 G-X-X-G motif; other site 690566003525 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 690566003526 RNA binding site [nucleotide binding]; other site 690566003527 domain interface; other site 690566003528 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 690566003529 16S/18S rRNA binding site [nucleotide binding]; other site 690566003530 S13e-L30e interaction site [polypeptide binding]; other site 690566003531 25S rRNA binding site [nucleotide binding]; other site 690566003532 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 690566003533 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 690566003534 RNA binding site [nucleotide binding]; other site 690566003535 active site 690566003536 thymidine kinase; Provisional; Region: PRK04296 690566003537 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 690566003538 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 690566003539 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 690566003540 translation initiation factor IF-2; Region: IF-2; TIGR00487 690566003541 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 690566003542 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 690566003543 G1 box; other site 690566003544 putative GEF interaction site [polypeptide binding]; other site 690566003545 GTP/Mg2+ binding site [chemical binding]; other site 690566003546 Switch I region; other site 690566003547 G2 box; other site 690566003548 G3 box; other site 690566003549 Switch II region; other site 690566003550 G4 box; other site 690566003551 G5 box; other site 690566003552 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 690566003553 Translation-initiation factor 2; Region: IF-2; pfam11987 690566003554 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 690566003555 hypothetical protein; Provisional; Region: PRK09190 690566003556 Protein of unknown function (DUF448); Region: DUF448; pfam04296 690566003557 putative RNA binding cleft [nucleotide binding]; other site 690566003558 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 690566003559 active site 1 [active] 690566003560 dimer interface [polypeptide binding]; other site 690566003561 hexamer interface [polypeptide binding]; other site 690566003562 active site 2 [active] 690566003563 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 690566003564 NusA N-terminal domain; Region: NusA_N; pfam08529 690566003565 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 690566003566 RNA binding site [nucleotide binding]; other site 690566003567 homodimer interface [polypeptide binding]; other site 690566003568 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 690566003569 G-X-X-G motif; other site 690566003570 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 690566003571 G-X-X-G motif; other site 690566003572 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 690566003573 hypothetical protein; Provisional; Region: PRK14636 690566003574 Sm and related proteins; Region: Sm_like; cl00259 690566003575 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 690566003576 putative oligomer interface [polypeptide binding]; other site 690566003577 putative RNA binding site [nucleotide binding]; other site 690566003578 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 690566003579 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 690566003580 CTP synthetase; Validated; Region: pyrG; PRK05380 690566003581 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 690566003582 Catalytic site [active] 690566003583 active site 690566003584 UTP binding site [chemical binding]; other site 690566003585 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 690566003586 active site 690566003587 putative oxyanion hole; other site 690566003588 catalytic triad [active] 690566003589 Preprotein translocase SecG subunit; Region: SecG; pfam03840 690566003590 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 690566003591 triosephosphate isomerase; Provisional; Region: PRK14565 690566003592 substrate binding site [chemical binding]; other site 690566003593 dimer interface [polypeptide binding]; other site 690566003594 catalytic triad [active] 690566003595 SurA N-terminal domain; Region: SurA_N_3; cl07813 690566003596 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 690566003597 anthranilate synthase component I; Provisional; Region: PRK13573 690566003598 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 690566003599 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 690566003600 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 690566003601 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566003602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566003603 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 690566003604 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 690566003605 active site 690566003606 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 690566003607 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 690566003608 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 690566003609 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 690566003610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 690566003611 Uncharacterized conserved protein [Function unknown]; Region: COG2308 690566003612 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 690566003613 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 690566003614 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 690566003615 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 690566003616 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 690566003617 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 690566003618 GspL periplasmic domain; Region: GspL_C; cl14909 690566003619 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 690566003620 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 690566003621 type II secretion system protein J; Region: gspJ; TIGR01711 690566003622 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 690566003623 type II secretion system protein I; Region: gspI; TIGR01707 690566003624 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 690566003625 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 690566003626 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 690566003627 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 690566003628 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 690566003629 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 690566003630 type II secretion system protein F; Region: GspF; TIGR02120 690566003631 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566003632 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566003633 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 690566003634 type II secretion system protein E; Region: type_II_gspE; TIGR02533 690566003635 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 690566003636 Walker A motif; other site 690566003637 ATP binding site [chemical binding]; other site 690566003638 Walker B motif; other site 690566003639 type II secretion system protein D; Region: type_II_gspD; TIGR02517 690566003640 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 690566003641 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 690566003642 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 690566003643 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 690566003644 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 690566003645 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 690566003646 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 690566003647 NRDE protein; Region: NRDE; cl01315 690566003648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566003649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003650 ATP binding site [chemical binding]; other site 690566003651 Mg2+ binding site [ion binding]; other site 690566003652 G-X-G motif; other site 690566003653 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 690566003654 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 690566003655 nudix motif; other site 690566003656 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 690566003657 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 690566003658 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 690566003659 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 690566003660 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 690566003661 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 690566003662 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 690566003663 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566003664 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566003666 putative substrate translocation pore; other site 690566003667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566003668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566003669 DNA binding site [nucleotide binding] 690566003670 domain linker motif; other site 690566003671 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 690566003672 putative ligand binding site [chemical binding]; other site 690566003673 putative dimerization interface [polypeptide binding]; other site 690566003674 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 690566003675 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566003676 ligand binding site [chemical binding]; other site 690566003677 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 690566003678 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566003679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566003680 putative DNA binding site [nucleotide binding]; other site 690566003681 putative Zn2+ binding site [ion binding]; other site 690566003682 AsnC family; Region: AsnC_trans_reg; pfam01037 690566003683 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 690566003684 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 690566003685 putative active site [active] 690566003686 putative catalytic site [active] 690566003687 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 690566003688 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 690566003689 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 690566003690 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 690566003691 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 690566003692 carboxyltransferase (CT) interaction site; other site 690566003693 biotinylation site [posttranslational modification]; other site 690566003694 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 690566003695 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 690566003696 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 690566003697 Protein of unknown function, DUF486; Region: DUF486; cl01236 690566003698 isovaleryl-CoA dehydrogenase; Region: PLN02519 690566003699 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 690566003700 substrate binding site [chemical binding]; other site 690566003701 FAD binding site [chemical binding]; other site 690566003702 catalytic base [active] 690566003703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566003704 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 690566003705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 690566003706 dimerization interface [polypeptide binding]; other site 690566003707 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 690566003708 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 690566003709 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 690566003710 active site 690566003711 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 690566003712 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 690566003713 active site 690566003714 (T/H)XGH motif; other site 690566003715 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 690566003716 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 690566003717 substrate binding pocket [chemical binding]; other site 690566003718 chain length determination region; other site 690566003719 substrate-Mg2+ binding site; other site 690566003720 catalytic residues [active] 690566003721 aspartate-rich region 1; other site 690566003722 active site lid residues [active] 690566003723 aspartate-rich region 2; other site 690566003724 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 690566003725 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 690566003726 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 690566003727 dimerization interface [polypeptide binding]; other site 690566003728 ATP binding site [chemical binding]; other site 690566003729 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 690566003730 dimerization interface [polypeptide binding]; other site 690566003731 ATP binding site [chemical binding]; other site 690566003732 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 690566003733 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 690566003734 ATP-grasp domain; Region: ATP-grasp; pfam02222 690566003735 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 690566003736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566003737 S-adenosylmethionine binding site [chemical binding]; other site 690566003738 Predicted membrane protein [Function unknown]; Region: COG2311 690566003739 Protein of unknown function (DUF418); Region: DUF418; cl12135 690566003740 Protein of unknown function (DUF418); Region: DUF418; pfam04235 690566003741 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 690566003742 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 690566003743 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 690566003744 heme binding site [chemical binding]; other site 690566003745 ferroxidase pore; other site 690566003746 ferroxidase diiron center [ion binding]; other site 690566003747 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 690566003748 active site 690566003749 8-oxo-dGMP binding site [chemical binding]; other site 690566003750 nudix motif; other site 690566003751 metal binding site [ion binding]; metal-binding site 690566003752 Flp/Fap pilin component; Region: Flp_Fap; cl01585 690566003753 Flp/Fap pilin component; Region: Flp_Fap; pfam04964 690566003754 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 690566003755 Peptidase family M48; Region: Peptidase_M48; cl12018 690566003756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 690566003757 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 690566003758 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 690566003759 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 690566003760 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566003761 active site 690566003762 DNA binding site [nucleotide binding] 690566003763 Int/Topo IB signature motif; other site 690566003764 shikimate kinase; Provisional; Region: PRK13946 690566003765 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 690566003766 ADP binding site [chemical binding]; other site 690566003767 magnesium binding site [ion binding]; other site 690566003768 putative shikimate binding site; other site 690566003769 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 690566003770 active site 690566003771 dimer interface [polypeptide binding]; other site 690566003772 metal binding site [ion binding]; metal-binding site 690566003773 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 690566003774 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 690566003775 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 690566003776 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 690566003777 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566003778 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566003779 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566003780 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566003781 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 690566003782 Surface antigen; Region: Bac_surface_Ag; pfam01103 690566003783 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 690566003784 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 690566003785 active site 690566003786 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 690566003787 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 690566003788 putative substrate binding region [chemical binding]; other site 690566003789 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 690566003790 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 690566003791 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 690566003792 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 690566003793 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 690566003794 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 690566003795 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 690566003796 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 690566003797 catalytic residue [active] 690566003798 putative FPP diphosphate binding site; other site 690566003799 putative FPP binding hydrophobic cleft; other site 690566003800 dimer interface [polypeptide binding]; other site 690566003801 putative IPP diphosphate binding site; other site 690566003802 ribosome recycling factor; Reviewed; Region: frr; PRK00083 690566003803 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 690566003804 hinge region; other site 690566003805 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 690566003806 putative nucleotide binding site [chemical binding]; other site 690566003807 uridine monophosphate binding site [chemical binding]; other site 690566003808 homohexameric interface [polypeptide binding]; other site 690566003809 elongation factor Ts; Provisional; Region: tsf; PRK09377 690566003810 UBA/TS-N domain; Region: UBA; pfam00627 690566003811 Elongation factor TS; Region: EF_TS; pfam00889 690566003812 Elongation factor TS; Region: EF_TS; pfam00889 690566003813 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 690566003814 rRNA interaction site [nucleotide binding]; other site 690566003815 S8 interaction site; other site 690566003816 putative laminin-1 binding site; other site 690566003817 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 690566003818 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 690566003819 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 690566003820 isocitrate dehydrogenase; Validated; Region: PRK08299 690566003821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566003822 Coenzyme A binding pocket [chemical binding]; other site 690566003823 Predicted amidohydrolase [General function prediction only]; Region: COG0388 690566003824 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 690566003825 putative active site [active] 690566003826 catalytic triad [active] 690566003827 putative dimer interface [polypeptide binding]; other site 690566003828 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 690566003829 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 690566003830 glutaminase active site [active] 690566003831 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 690566003832 dimer interface [polypeptide binding]; other site 690566003833 active site 690566003834 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 690566003835 dimer interface [polypeptide binding]; other site 690566003836 active site 690566003837 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 690566003838 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566003839 putative active site [active] 690566003840 putative metal binding site [ion binding]; other site 690566003841 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 690566003842 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 690566003843 Substrate binding site; other site 690566003844 Mg++ binding site; other site 690566003845 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 690566003846 active site 690566003847 substrate binding site [chemical binding]; other site 690566003848 CoA binding site [chemical binding]; other site 690566003849 phosphoglycolate phosphatase; Provisional; Region: PRK13222 690566003850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566003851 motif II; other site 690566003852 enoyl-CoA hydratase; Provisional; Region: PRK06127 690566003853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566003854 substrate binding site [chemical binding]; other site 690566003855 oxyanion hole (OAH) forming residues; other site 690566003856 trimer interface [polypeptide binding]; other site 690566003857 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566003858 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566003859 metal binding site [ion binding]; metal-binding site 690566003860 active site 690566003861 I-site; other site 690566003862 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 690566003863 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 690566003864 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566003865 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 690566003866 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 690566003867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566003868 E3 interaction surface; other site 690566003869 lipoyl attachment site [posttranslational modification]; other site 690566003870 e3 binding domain; Region: E3_binding; pfam02817 690566003871 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566003872 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 690566003873 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 690566003874 TPP-binding site [chemical binding]; other site 690566003875 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 690566003876 dimer interface [polypeptide binding]; other site 690566003877 PYR/PP interface [polypeptide binding]; other site 690566003878 TPP binding site [chemical binding]; other site 690566003879 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 690566003880 CoA binding domain; Region: CoA_binding; smart00881 690566003881 CoA-ligase; Region: Ligase_CoA; pfam00549 690566003882 malate dehydrogenase; Reviewed; Region: PRK06223 690566003883 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 690566003884 NAD(P) binding site [chemical binding]; other site 690566003885 dimer interface [polypeptide binding]; other site 690566003886 tetramer (dimer of dimers) interface [polypeptide binding]; other site 690566003887 substrate binding site [chemical binding]; other site 690566003888 Predicted ATPase [General function prediction only]; Region: COG1485 690566003889 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 690566003890 CoenzymeA binding site [chemical binding]; other site 690566003891 subunit interaction site [polypeptide binding]; other site 690566003892 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 690566003893 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 690566003894 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 690566003895 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 690566003896 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 690566003897 HIT family signature motif; other site 690566003898 catalytic residue [active] 690566003899 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 690566003900 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 690566003901 active site 690566003902 metal-binding site 690566003903 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 690566003904 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 690566003905 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 690566003906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 690566003907 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 690566003908 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 690566003909 Serine hydrolase; Region: Ser_hydrolase; cl17834 690566003910 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 690566003911 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 690566003912 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 690566003913 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 690566003914 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 690566003915 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 690566003916 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 690566003917 Type IV pili component [Cell motility and secretion]; Region: COG5461 690566003918 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 690566003919 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 690566003920 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 690566003921 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566003922 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 690566003923 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566003924 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 690566003925 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 690566003926 active site 690566003927 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 690566003928 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 690566003929 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 690566003930 Membrane fusogenic activity; Region: BMFP; pfam04380 690566003931 TspO/MBR family; Region: TspO_MBR; pfam03073 690566003932 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 690566003933 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566003934 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566003935 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 690566003936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566003937 RNA binding surface [nucleotide binding]; other site 690566003938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566003939 S-adenosylmethionine binding site [chemical binding]; other site 690566003940 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 690566003941 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 690566003942 DsbD alpha interface [polypeptide binding]; other site 690566003943 catalytic residues [active] 690566003944 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 690566003945 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 690566003946 Penicillinase repressor; Region: Pencillinase_R; cl17580 690566003947 serine O-acetyltransferase; Region: cysE; TIGR01172 690566003948 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 690566003949 trimer interface [polypeptide binding]; other site 690566003950 active site 690566003951 substrate binding site [chemical binding]; other site 690566003952 CoA binding site [chemical binding]; other site 690566003953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 690566003954 dimerization interface [polypeptide binding]; other site 690566003955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566003956 ATP binding site [chemical binding]; other site 690566003957 Mg2+ binding site [ion binding]; other site 690566003958 G-X-G motif; other site 690566003959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566003960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003961 active site 690566003962 phosphorylation site [posttranslational modification] 690566003963 intermolecular recognition site; other site 690566003964 dimerization interface [polypeptide binding]; other site 690566003965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566003966 DNA binding site [nucleotide binding] 690566003967 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 690566003968 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 690566003969 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 690566003970 Sulfate transporter family; Region: Sulfate_transp; pfam00916 690566003971 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 690566003972 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 690566003973 active site clefts [active] 690566003974 zinc binding site [ion binding]; other site 690566003975 dimer interface [polypeptide binding]; other site 690566003976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566003977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566003978 active site 690566003979 phosphorylation site [posttranslational modification] 690566003980 intermolecular recognition site; other site 690566003981 dimerization interface [polypeptide binding]; other site 690566003982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566003983 DNA binding site [nucleotide binding] 690566003984 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 690566003985 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566003986 putative ADP-binding pocket [chemical binding]; other site 690566003987 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 690566003988 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 690566003989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566003990 NAD(P) binding site [chemical binding]; other site 690566003991 active site 690566003992 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566003993 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566003994 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566003995 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 690566003996 putative active site [active] 690566003997 putative metal binding residues [ion binding]; other site 690566003998 signature motif; other site 690566003999 putative dimer interface [polypeptide binding]; other site 690566004000 putative phosphate binding site [ion binding]; other site 690566004001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 690566004002 EamA-like transporter family; Region: EamA; pfam00892 690566004003 chorismate mutase; Provisional; Region: PRK09239 690566004004 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 690566004005 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 690566004006 substrate binding pocket [chemical binding]; other site 690566004007 chain length determination region; other site 690566004008 substrate-Mg2+ binding site; other site 690566004009 catalytic residues [active] 690566004010 aspartate-rich region 1; other site 690566004011 active site lid residues [active] 690566004012 aspartate-rich region 2; other site 690566004013 hypothetical protein; Provisional; Region: PRK10621 690566004014 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566004015 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 690566004016 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566004017 ATP binding site [chemical binding]; other site 690566004018 putative Mg++ binding site [ion binding]; other site 690566004019 nucleotide binding region [chemical binding]; other site 690566004020 helicase superfamily c-terminal domain; Region: HELICc; smart00490 690566004021 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 690566004022 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 690566004023 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 690566004024 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 690566004025 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 690566004026 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 690566004027 substrate-cofactor binding pocket; other site 690566004028 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004029 catalytic residue [active] 690566004030 CHASE3 domain; Region: CHASE3; pfam05227 690566004031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566004032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566004033 ATP binding site [chemical binding]; other site 690566004034 Mg2+ binding site [ion binding]; other site 690566004035 G-X-G motif; other site 690566004036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566004037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004038 active site 690566004039 phosphorylation site [posttranslational modification] 690566004040 intermolecular recognition site; other site 690566004041 dimerization interface [polypeptide binding]; other site 690566004042 Protein of unknown function (DUF938); Region: DUF938; pfam06080 690566004043 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 690566004044 tetramer interface [polypeptide binding]; other site 690566004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004046 catalytic residue [active] 690566004047 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 690566004048 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 690566004049 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566004050 catalytic residue [active] 690566004051 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 690566004052 lipoyl attachment site [posttranslational modification]; other site 690566004053 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 690566004054 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 690566004055 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 690566004056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 690566004057 Zn2+ binding site [ion binding]; other site 690566004058 Mg2+ binding site [ion binding]; other site 690566004059 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 690566004060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566004061 binding surface 690566004062 TPR motif; other site 690566004063 Sporulation related domain; Region: SPOR; pfam05036 690566004064 cell division protein FtsZ; Validated; Region: PRK09330 690566004065 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 690566004066 nucleotide binding site [chemical binding]; other site 690566004067 SulA interaction site; other site 690566004068 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 690566004069 Cell division protein FtsA; Region: FtsA; smart00842 690566004070 Cell division protein FtsA; Region: FtsA; pfam14450 690566004071 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 690566004072 Cell division protein FtsQ; Region: FtsQ; pfam03799 690566004073 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 690566004074 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 690566004075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 690566004076 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 690566004077 FAD binding domain; Region: FAD_binding_4; pfam01565 690566004078 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 690566004079 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 690566004080 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 690566004081 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 690566004082 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 690566004083 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 690566004084 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 690566004085 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 690566004086 active site 690566004087 homodimer interface [polypeptide binding]; other site 690566004088 cell division protein FtsW; Region: ftsW; TIGR02614 690566004089 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 690566004090 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 690566004091 NAD(P) binding pocket [chemical binding]; other site 690566004092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 690566004093 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 690566004094 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 690566004095 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 690566004096 Mg++ binding site [ion binding]; other site 690566004097 putative catalytic motif [active] 690566004098 putative substrate binding site [chemical binding]; other site 690566004099 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 690566004100 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 690566004101 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 690566004102 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 690566004103 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 690566004104 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 690566004105 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 690566004106 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 690566004107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 690566004108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 690566004109 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 690566004110 MraW methylase family; Region: Methyltransf_5; cl17771 690566004111 cell division protein MraZ; Reviewed; Region: PRK00326 690566004112 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 690566004113 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 690566004114 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 690566004115 dimer interface [polypeptide binding]; other site 690566004116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004117 catalytic residue [active] 690566004118 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 690566004119 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 690566004120 Predicted small secreted protein [Function unknown]; Region: COG5510 690566004121 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 690566004122 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 690566004123 twin arginine translocase protein A; Provisional; Region: tatA; PRK00720 690566004124 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 690566004125 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 690566004126 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 690566004127 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 690566004128 Sporulation related domain; Region: SPOR; pfam05036 690566004129 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 690566004130 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 690566004131 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 690566004132 active site 690566004133 HIGH motif; other site 690566004134 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566004135 KMSK motif region; other site 690566004136 tRNA binding surface [nucleotide binding]; other site 690566004137 DALR anticodon binding domain; Region: DALR_1; smart00836 690566004138 anticodon binding site; other site 690566004139 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 690566004140 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 690566004141 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 690566004142 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 690566004143 putative active site [active] 690566004144 putative substrate binding site [chemical binding]; other site 690566004145 ATP binding site [chemical binding]; other site 690566004146 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 690566004147 RNA/DNA hybrid binding site [nucleotide binding]; other site 690566004148 active site 690566004149 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 690566004150 dihydropteroate synthase; Region: DHPS; TIGR01496 690566004151 substrate binding pocket [chemical binding]; other site 690566004152 dimer interface [polypeptide binding]; other site 690566004153 inhibitor binding site; inhibition site 690566004154 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 690566004155 DNA methylase; Region: N6_N4_Mtase; pfam01555 690566004156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566004157 dimerization interface [polypeptide binding]; other site 690566004158 putative DNA binding site [nucleotide binding]; other site 690566004159 putative Zn2+ binding site [ion binding]; other site 690566004160 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 690566004161 active site 690566004162 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566004163 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566004164 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566004165 nucleotide binding region [chemical binding]; other site 690566004166 ATP-binding site [chemical binding]; other site 690566004167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 690566004168 RNA binding surface [nucleotide binding]; other site 690566004169 Ferredoxin [Energy production and conversion]; Region: COG1146 690566004170 4Fe-4S binding domain; Region: Fer4; cl02805 690566004171 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 690566004172 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 690566004173 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 690566004174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566004175 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 690566004176 peroxiredoxin; Region: AhpC; TIGR03137 690566004177 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 690566004178 dimer interface [polypeptide binding]; other site 690566004179 decamer (pentamer of dimers) interface [polypeptide binding]; other site 690566004180 catalytic triad [active] 690566004181 peroxidatic and resolving cysteines [active] 690566004182 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 690566004183 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 690566004184 catalytic residue [active] 690566004185 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 690566004186 catalytic residues [active] 690566004187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566004188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566004189 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 690566004190 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 690566004191 RNA/DNA hybrid binding site [nucleotide binding]; other site 690566004192 active site 690566004193 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 690566004194 dimer interface [polypeptide binding]; other site 690566004195 substrate binding site [chemical binding]; other site 690566004196 ATP binding site [chemical binding]; other site 690566004197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 690566004198 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 690566004199 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 690566004200 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 690566004201 active site 690566004202 substrate binding site [chemical binding]; other site 690566004203 metal binding site [ion binding]; metal-binding site 690566004204 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 690566004205 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 690566004206 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 690566004207 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 690566004208 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 690566004209 active site 690566004210 ParB-like nuclease domain; Region: ParBc; pfam02195 690566004211 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 690566004212 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 690566004213 DNA methylase; Region: N6_N4_Mtase; pfam01555 690566004214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 690566004215 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 690566004216 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 690566004217 HTH-like domain; Region: HTH_21; pfam13276 690566004218 Integrase core domain; Region: rve; pfam00665 690566004219 Integrase core domain; Region: rve_3; pfam13683 690566004220 Transposase; Region: HTH_Tnp_1; cl17663 690566004221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 690566004222 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 690566004223 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566004224 Walker A motif; other site 690566004225 hexamer interface [polypeptide binding]; other site 690566004226 ATP binding site [chemical binding]; other site 690566004227 Walker B motif; other site 690566004228 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 690566004229 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 690566004230 VirB7 interaction site; other site 690566004231 VirB8 protein; Region: VirB8; pfam04335 690566004232 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 690566004233 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 690566004234 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 690566004235 Type IV secretory pathway, VirB3 components [Intracellular trafficking and secretion]; Region: VirB3; COG3702 690566004236 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 690566004237 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 690566004238 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 690566004239 RHS Repeat; Region: RHS_repeat; pfam05593 690566004240 RHS Repeat; Region: RHS_repeat; pfam05593 690566004241 RHS Repeat; Region: RHS_repeat; cl11982 690566004242 RHS Repeat; Region: RHS_repeat; pfam05593 690566004243 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 690566004244 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 690566004245 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 690566004246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566004247 NAD(P) binding site [chemical binding]; other site 690566004248 Protein of unknown function, DUF393; Region: DUF393; pfam04134 690566004249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566004250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 690566004251 non-specific DNA binding site [nucleotide binding]; other site 690566004252 salt bridge; other site 690566004253 sequence-specific DNA binding site [nucleotide binding]; other site 690566004254 Domain of unknown function (DUF955); Region: DUF955; cl01076 690566004255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566004256 ATP binding site [chemical binding]; other site 690566004257 putative Mg++ binding site [ion binding]; other site 690566004258 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 690566004259 Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659 690566004260 5' RNA guide strand anchoring site; other site 690566004261 active site 690566004262 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 690566004263 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 690566004264 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 690566004265 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 690566004266 catalytic residues [active] 690566004267 catalytic nucleophile [active] 690566004268 Presynaptic Site I dimer interface [polypeptide binding]; other site 690566004269 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 690566004270 Synaptic Flat tetramer interface [polypeptide binding]; other site 690566004271 Synaptic Site I dimer interface [polypeptide binding]; other site 690566004272 DNA binding site [nucleotide binding] 690566004273 Recombinase; Region: Recombinase; pfam07508 690566004274 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 690566004275 nitrilase; Region: PLN02798 690566004276 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 690566004277 putative active site [active] 690566004278 catalytic triad [active] 690566004279 dimer interface [polypeptide binding]; other site 690566004280 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 690566004281 GSH binding site [chemical binding]; other site 690566004282 catalytic residues [active] 690566004283 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 690566004284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566004285 active site 690566004286 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566004287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566004288 S-adenosylmethionine binding site [chemical binding]; other site 690566004289 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 690566004290 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 690566004291 Predicted permeases [General function prediction only]; Region: COG0795 690566004292 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 690566004293 Predicted permeases [General function prediction only]; Region: COG0795 690566004294 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 690566004295 Fatty acid desaturase; Region: FA_desaturase; pfam00487 690566004296 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 690566004297 putative di-iron ligands [ion binding]; other site 690566004298 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 690566004299 putative acetyltransferase; Provisional; Region: PRK03624 690566004300 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 690566004301 putative lipid kinase; Reviewed; Region: PRK13057 690566004302 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566004303 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 690566004304 putative active site [active] 690566004305 putative metal binding site [ion binding]; other site 690566004306 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 690566004307 putative catalytic site [active] 690566004308 putative phosphate binding site [ion binding]; other site 690566004309 active site 690566004310 metal binding site A [ion binding]; metal-binding site 690566004311 DNA binding site [nucleotide binding] 690566004312 putative AP binding site [nucleotide binding]; other site 690566004313 putative metal binding site B [ion binding]; other site 690566004314 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 690566004315 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566004316 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566004317 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 690566004318 dinuclear metal binding motif [ion binding]; other site 690566004319 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 690566004320 catalytic triad [active] 690566004321 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 690566004322 metal binding triad; other site 690566004323 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 690566004324 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 690566004325 metal binding triad; other site 690566004326 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 690566004327 Predicted metalloprotease [General function prediction only]; Region: COG2321 690566004328 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 690566004329 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 690566004330 nucleophile elbow; other site 690566004331 Patatin phospholipase; Region: DUF3734; pfam12536 690566004332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566004333 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 690566004334 NAD(P) binding site [chemical binding]; other site 690566004335 active site 690566004336 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 690566004337 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 690566004338 metal binding site [ion binding]; metal-binding site 690566004339 putative dimer interface [polypeptide binding]; other site 690566004340 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 690566004341 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 690566004342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566004343 dimer interface [polypeptide binding]; other site 690566004344 phosphorylation site [posttranslational modification] 690566004345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566004346 ATP binding site [chemical binding]; other site 690566004347 Mg2+ binding site [ion binding]; other site 690566004348 G-X-G motif; other site 690566004349 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 690566004350 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 690566004351 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 690566004352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 690566004353 dimer interface [polypeptide binding]; other site 690566004354 conserved gate region; other site 690566004355 putative PBP binding loops; other site 690566004356 ABC-ATPase subunit interface; other site 690566004357 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 690566004358 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 690566004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 690566004360 dimer interface [polypeptide binding]; other site 690566004361 conserved gate region; other site 690566004362 putative PBP binding loops; other site 690566004363 ABC-ATPase subunit interface; other site 690566004364 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 690566004365 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 690566004366 Walker A/P-loop; other site 690566004367 ATP binding site [chemical binding]; other site 690566004368 Q-loop/lid; other site 690566004369 ABC transporter signature motif; other site 690566004370 Walker B; other site 690566004371 D-loop; other site 690566004372 H-loop/switch region; other site 690566004373 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 690566004374 PhoU domain; Region: PhoU; pfam01895 690566004375 PhoU domain; Region: PhoU; pfam01895 690566004376 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 690566004377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004378 active site 690566004379 phosphorylation site [posttranslational modification] 690566004380 intermolecular recognition site; other site 690566004381 dimerization interface [polypeptide binding]; other site 690566004382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566004383 DNA binding site [nucleotide binding] 690566004384 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 690566004385 active site 690566004386 catalytic residues [active] 690566004387 metal binding site [ion binding]; metal-binding site 690566004388 recombination protein RecR; Reviewed; Region: recR; PRK00076 690566004389 RecR protein; Region: RecR; pfam02132 690566004390 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 690566004391 putative active site [active] 690566004392 putative metal-binding site [ion binding]; other site 690566004393 tetramer interface [polypeptide binding]; other site 690566004394 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 690566004395 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 690566004396 putative active site [active] 690566004397 substrate binding site [chemical binding]; other site 690566004398 putative cosubstrate binding site; other site 690566004399 catalytic site [active] 690566004400 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 690566004401 substrate binding site [chemical binding]; other site 690566004402 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 690566004403 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 690566004404 dimerization interface 3.5A [polypeptide binding]; other site 690566004405 active site 690566004406 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 690566004407 Cupin-like domain; Region: Cupin_8; pfam13621 690566004408 Uncharacterized conserved protein [Function unknown]; Region: COG2850 690566004409 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 690566004410 pseudouridine synthase; Region: TIGR00093 690566004411 active site 690566004412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 690566004413 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 690566004414 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 690566004415 NADP binding site [chemical binding]; other site 690566004416 dimer interface [polypeptide binding]; other site 690566004417 methionine sulfoxide reductase A; Provisional; Region: PRK13014 690566004418 aspartate aminotransferase; Provisional; Region: PRK05764 690566004419 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566004420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004421 homodimer interface [polypeptide binding]; other site 690566004422 catalytic residue [active] 690566004423 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 690566004424 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 690566004425 substrate-cofactor binding pocket; other site 690566004426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004427 catalytic residue [active] 690566004428 aminodeoxychorismate synthase; Provisional; Region: PRK07508 690566004429 chorismate binding enzyme; Region: Chorismate_bind; cl10555 690566004430 Protein of unknown function (DUF983); Region: DUF983; cl02211 690566004431 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 690566004432 active site 690566004433 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 690566004434 YceI-like domain; Region: YceI; pfam04264 690566004435 Domain of unknown function DUF20; Region: UPF0118; pfam01594 690566004436 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 690566004437 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 690566004438 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566004439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566004440 ABC transporter; Region: ABC_tran_2; pfam12848 690566004441 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 690566004442 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 690566004443 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 690566004444 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 690566004445 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 690566004446 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 690566004447 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 690566004448 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 690566004449 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 690566004450 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 690566004451 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 690566004452 minor groove reading motif; other site 690566004453 helix-hairpin-helix signature motif; other site 690566004454 substrate binding pocket [chemical binding]; other site 690566004455 active site 690566004456 Response regulator receiver domain; Region: Response_reg; pfam00072 690566004457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004458 active site 690566004459 phosphorylation site [posttranslational modification] 690566004460 intermolecular recognition site; other site 690566004461 dimerization interface [polypeptide binding]; other site 690566004462 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 690566004463 GAF domain; Region: GAF; pfam01590 690566004464 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566004465 PAS fold; Region: PAS_3; pfam08447 690566004466 putative active site [active] 690566004467 heme pocket [chemical binding]; other site 690566004468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 690566004469 HWE histidine kinase; Region: HWE_HK; smart00911 690566004470 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 690566004471 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 690566004472 hinge; other site 690566004473 active site 690566004474 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 690566004475 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566004476 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566004477 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 690566004478 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 690566004479 Methyltransferase domain; Region: Methyltransf_18; pfam12847 690566004480 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566004481 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566004482 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 690566004483 putative C-terminal domain interface [polypeptide binding]; other site 690566004484 putative GSH binding site (G-site) [chemical binding]; other site 690566004485 putative dimer interface [polypeptide binding]; other site 690566004486 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 690566004487 putative substrate binding pocket (H-site) [chemical binding]; other site 690566004488 putative N-terminal domain interface [polypeptide binding]; other site 690566004489 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 690566004490 active site 690566004491 multimer interface [polypeptide binding]; other site 690566004492 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 690566004493 multifunctional aminopeptidase A; Provisional; Region: PRK00913 690566004494 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 690566004495 interface (dimer of trimers) [polypeptide binding]; other site 690566004496 Substrate-binding/catalytic site; other site 690566004497 Zn-binding sites [ion binding]; other site 690566004498 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 690566004499 OstA-like protein; Region: OstA; cl00844 690566004500 Organic solvent tolerance protein; Region: OstA_C; pfam04453 690566004501 SurA N-terminal domain; Region: SurA_N; pfam09312 690566004502 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 690566004503 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 690566004504 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 690566004505 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 690566004506 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 690566004507 S-adenosylmethionine binding site [chemical binding]; other site 690566004508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566004509 binding surface 690566004510 Tetratricopeptide repeat; Region: TPR_16; pfam13432 690566004511 TPR motif; other site 690566004512 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 690566004513 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 690566004514 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 690566004515 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 690566004516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 690566004517 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 690566004518 active site 690566004519 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 690566004520 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 690566004521 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 690566004522 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 690566004523 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 690566004524 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 690566004525 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 690566004526 active site 690566004527 dimer interface [polypeptide binding]; other site 690566004528 motif 1; other site 690566004529 motif 2; other site 690566004530 motif 3; other site 690566004531 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 690566004532 anticodon binding site; other site 690566004533 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 690566004534 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 690566004535 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 690566004536 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 690566004537 ATP binding site [chemical binding]; other site 690566004538 substrate interface [chemical binding]; other site 690566004539 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 690566004540 trimer interface [polypeptide binding]; other site 690566004541 active site 690566004542 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 690566004543 Flavoprotein; Region: Flavoprotein; pfam02441 690566004544 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 690566004545 FtsH Extracellular; Region: FtsH_ext; pfam06480 690566004546 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 690566004547 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566004548 Walker A motif; other site 690566004549 ATP binding site [chemical binding]; other site 690566004550 Walker B motif; other site 690566004551 arginine finger; other site 690566004552 Peptidase family M41; Region: Peptidase_M41; pfam01434 690566004553 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 690566004554 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 690566004555 Ligand Binding Site [chemical binding]; other site 690566004556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 690566004557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566004558 non-specific DNA binding site [nucleotide binding]; other site 690566004559 salt bridge; other site 690566004560 sequence-specific DNA binding site [nucleotide binding]; other site 690566004561 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 690566004562 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 690566004563 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 690566004564 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 690566004565 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 690566004566 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 690566004567 putative aminotransferase; Provisional; Region: PRK09105 690566004568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566004569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004570 homodimer interface [polypeptide binding]; other site 690566004571 catalytic residue [active] 690566004572 putative aminotransferase; Provisional; Region: PRK09105 690566004573 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566004574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566004575 homodimer interface [polypeptide binding]; other site 690566004576 catalytic residue [active] 690566004577 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 690566004578 hydrophobic ligand binding site; other site 690566004579 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566004580 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 690566004581 dimer interface [polypeptide binding]; other site 690566004582 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566004583 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 690566004584 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 690566004585 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566004586 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 690566004587 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 690566004588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566004589 NAD(P) binding site [chemical binding]; other site 690566004590 active site 690566004591 Predicted transcriptional regulators [Transcription]; Region: COG1733 690566004592 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 690566004593 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 690566004594 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566004595 FMN binding site [chemical binding]; other site 690566004596 substrate binding site [chemical binding]; other site 690566004597 putative catalytic residue [active] 690566004598 aspartate kinase; Reviewed; Region: PRK06635 690566004599 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 690566004600 putative nucleotide binding site [chemical binding]; other site 690566004601 putative catalytic residues [active] 690566004602 putative Mg ion binding site [ion binding]; other site 690566004603 putative aspartate binding site [chemical binding]; other site 690566004604 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 690566004605 putative allosteric regulatory site; other site 690566004606 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 690566004607 putative allosteric regulatory residue; other site 690566004608 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 690566004609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566004610 S-adenosylmethionine binding site [chemical binding]; other site 690566004611 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 690566004612 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 690566004613 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 690566004614 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 690566004615 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 690566004616 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 690566004617 FAD binding pocket [chemical binding]; other site 690566004618 FAD binding motif [chemical binding]; other site 690566004619 phosphate binding motif [ion binding]; other site 690566004620 beta-alpha-beta structure motif; other site 690566004621 NAD binding pocket [chemical binding]; other site 690566004622 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 690566004623 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 690566004624 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 690566004625 active site 690566004626 substrate-binding site [chemical binding]; other site 690566004627 metal-binding site [ion binding] 690566004628 ATP binding site [chemical binding]; other site 690566004629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566004630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004631 active site 690566004632 phosphorylation site [posttranslational modification] 690566004633 intermolecular recognition site; other site 690566004634 dimerization interface [polypeptide binding]; other site 690566004635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566004636 DNA binding site [nucleotide binding] 690566004637 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 690566004638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566004639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566004640 dimer interface [polypeptide binding]; other site 690566004641 phosphorylation site [posttranslational modification] 690566004642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566004643 ATP binding site [chemical binding]; other site 690566004644 Mg2+ binding site [ion binding]; other site 690566004645 G-X-G motif; other site 690566004646 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 690566004647 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 690566004648 Hpr binding site; other site 690566004649 active site 690566004650 homohexamer subunit interaction site [polypeptide binding]; other site 690566004651 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 690566004652 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 690566004653 active pocket/dimerization site; other site 690566004654 active site 690566004655 phosphorylation site [posttranslational modification] 690566004656 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 690566004657 dimerization domain swap beta strand [polypeptide binding]; other site 690566004658 regulatory protein interface [polypeptide binding]; other site 690566004659 active site 690566004660 regulatory phosphorylation site [posttranslational modification]; other site 690566004661 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 690566004662 GAF domain; Region: GAF; pfam01590 690566004663 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566004664 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566004665 metal binding site [ion binding]; metal-binding site 690566004666 active site 690566004667 I-site; other site 690566004668 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 690566004669 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 690566004670 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 690566004671 metabolite-proton symporter; Region: 2A0106; TIGR00883 690566004672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 690566004673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 690566004674 Coenzyme A binding pocket [chemical binding]; other site 690566004675 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566004676 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566004677 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566004678 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 690566004679 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 690566004680 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 690566004681 RimM N-terminal domain; Region: RimM; pfam01782 690566004682 PRC-barrel domain; Region: PRC; pfam05239 690566004683 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 690566004684 signal recognition particle protein; Provisional; Region: PRK10867 690566004685 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 690566004686 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 690566004687 P loop; other site 690566004688 GTP binding site [chemical binding]; other site 690566004689 Signal peptide binding domain; Region: SRP_SPB; pfam02978 690566004690 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 690566004691 amino acid transporter; Region: 2A0306; TIGR00909 690566004692 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 690566004693 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 690566004694 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 690566004695 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 690566004696 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 690566004697 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 690566004698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566004699 FeS/SAM binding site; other site 690566004700 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 690566004701 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 690566004702 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 690566004703 P loop; other site 690566004704 GTP binding site [chemical binding]; other site 690566004705 Intracellular septation protein A; Region: IspA; pfam04279 690566004706 Predicted membrane protein [Function unknown]; Region: COG3748 690566004707 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 690566004708 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 690566004709 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 690566004710 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 690566004711 Protein of unknown function (DUF1636); Region: DUF1636; cl17843 690566004712 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 690566004713 HSP70 interaction site [polypeptide binding]; other site 690566004714 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 690566004715 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 690566004716 amidase catalytic site [active] 690566004717 Zn binding residues [ion binding]; other site 690566004718 substrate binding site [chemical binding]; other site 690566004719 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 690566004720 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 690566004721 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 690566004722 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 690566004723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004724 active site 690566004725 phosphorylation site [posttranslational modification] 690566004726 intermolecular recognition site; other site 690566004727 dimerization interface [polypeptide binding]; other site 690566004728 CheB methylesterase; Region: CheB_methylest; pfam01339 690566004729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004730 Response regulator receiver domain; Region: Response_reg; pfam00072 690566004731 active site 690566004732 phosphorylation site [posttranslational modification] 690566004733 intermolecular recognition site; other site 690566004734 dimerization interface [polypeptide binding]; other site 690566004735 CheW-like domain; Region: CheW; pfam01584 690566004736 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 690566004737 putative binding surface; other site 690566004738 active site 690566004739 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 690566004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566004741 ATP binding site [chemical binding]; other site 690566004742 Mg2+ binding site [ion binding]; other site 690566004743 G-X-G motif; other site 690566004744 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 690566004745 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 690566004746 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 690566004747 LemA family; Region: LemA; cl00742 690566004748 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 690566004749 Repair protein; Region: Repair_PSII; pfam04536 690566004750 Repair protein; Region: Repair_PSII; cl01535 690566004751 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 690566004752 ADP-ribose binding site [chemical binding]; other site 690566004753 dimer interface [polypeptide binding]; other site 690566004754 active site 690566004755 nudix motif; other site 690566004756 metal binding site [ion binding]; metal-binding site 690566004757 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 690566004758 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566004759 non-specific DNA binding site [nucleotide binding]; other site 690566004760 salt bridge; other site 690566004761 sequence-specific DNA binding site [nucleotide binding]; other site 690566004762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566004763 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 690566004764 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 690566004765 molybdopterin cofactor binding site; other site 690566004766 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 690566004767 Eukaryotic phosphomannomutase; Region: PMM; cl17107 690566004768 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 690566004769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 690566004770 putative PBP binding loops; other site 690566004771 ABC-ATPase subunit interface; other site 690566004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566004773 ATP binding site [chemical binding]; other site 690566004774 ABC transporter; Region: ABC_tran; pfam00005 690566004775 Q-loop/lid; other site 690566004776 ABC transporter signature motif; other site 690566004777 Walker B; other site 690566004778 D-loop; other site 690566004779 H-loop/switch region; other site 690566004780 Phosphotransferase enzyme family; Region: APH; pfam01636 690566004781 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 690566004782 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 690566004783 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 690566004784 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 690566004785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566004786 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 690566004787 HIT family signature motif; other site 690566004788 catalytic residue [active] 690566004789 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 690566004790 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 690566004791 thiS-thiF/thiG interaction site; other site 690566004792 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 690566004793 ThiS interaction site; other site 690566004794 putative active site [active] 690566004795 tetramer interface [polypeptide binding]; other site 690566004796 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 690566004797 Dehydroquinase class II; Region: DHquinase_II; pfam01220 690566004798 trimer interface [polypeptide binding]; other site 690566004799 active site 690566004800 dimer interface [polypeptide binding]; other site 690566004801 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 690566004802 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 690566004803 carboxyltransferase (CT) interaction site; other site 690566004804 biotinylation site [posttranslational modification]; other site 690566004805 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 690566004806 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 690566004807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 690566004808 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 690566004809 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 690566004810 ArsC family; Region: ArsC; pfam03960 690566004811 catalytic residues [active] 690566004812 DNA polymerase I; Provisional; Region: PRK05755 690566004813 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 690566004814 active site 690566004815 metal binding site 1 [ion binding]; metal-binding site 690566004816 putative 5' ssDNA interaction site; other site 690566004817 metal binding site 3; metal-binding site 690566004818 metal binding site 2 [ion binding]; metal-binding site 690566004819 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 690566004820 putative DNA binding site [nucleotide binding]; other site 690566004821 putative metal binding site [ion binding]; other site 690566004822 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 690566004823 active site 690566004824 catalytic site [active] 690566004825 substrate binding site [chemical binding]; other site 690566004826 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 690566004827 active site 690566004828 DNA binding site [nucleotide binding] 690566004829 catalytic site [active] 690566004830 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 690566004831 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 690566004832 Substrate binding site; other site 690566004833 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 690566004834 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 690566004835 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 690566004836 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 690566004837 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 690566004838 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566004839 active site 690566004840 HIGH motif; other site 690566004841 nucleotide binding site [chemical binding]; other site 690566004842 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566004843 active site 690566004844 KMSKS motif; other site 690566004845 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 690566004846 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 690566004847 AAA domain; Region: AAA_31; pfam13614 690566004848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566004849 P-loop; other site 690566004850 Magnesium ion binding site [ion binding]; other site 690566004851 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566004852 Magnesium ion binding site [ion binding]; other site 690566004853 acyl-CoA synthetase; Validated; Region: PRK09192 690566004854 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 690566004855 acyl-activating enzyme (AAE) consensus motif; other site 690566004856 active site 690566004857 RecX family; Region: RecX; pfam02631 690566004858 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 690566004859 NADH dehydrogenase; Validated; Region: PRK08183 690566004860 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 690566004861 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 690566004862 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 690566004863 L-aspartate oxidase; Provisional; Region: PRK06175 690566004864 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 690566004865 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 690566004866 putative SdhC subunit interface [polypeptide binding]; other site 690566004867 putative proximal heme binding site [chemical binding]; other site 690566004868 putative Iron-sulfur protein interface [polypeptide binding]; other site 690566004869 putative proximal quinone binding site; other site 690566004870 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 690566004871 Iron-sulfur protein interface; other site 690566004872 proximal quinone binding site [chemical binding]; other site 690566004873 SdhD (CybS) interface [polypeptide binding]; other site 690566004874 proximal heme binding site [chemical binding]; other site 690566004875 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 690566004876 dimer interface [polypeptide binding]; other site 690566004877 putative CheW interface [polypeptide binding]; other site 690566004878 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 690566004879 Methyltransferase domain; Region: Methyltransf_18; pfam12847 690566004880 Dienelactone hydrolase family; Region: DLH; pfam01738 690566004881 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566004882 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 690566004883 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 690566004884 dimerization interface [polypeptide binding]; other site 690566004885 active site 690566004886 quinolinate synthetase; Provisional; Region: PRK09375 690566004887 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 690566004888 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 690566004889 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 690566004890 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566004891 active site 690566004892 DNA binding site [nucleotide binding] 690566004893 Int/Topo IB signature motif; other site 690566004894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 690566004895 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 690566004896 glutathione synthetase; Provisional; Region: PRK05246 690566004897 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 690566004898 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 690566004899 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 690566004900 Predicted methyltransferases [General function prediction only]; Region: COG0313 690566004901 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 690566004902 putative SAM binding site [chemical binding]; other site 690566004903 putative homodimer interface [polypeptide binding]; other site 690566004904 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 690566004905 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 690566004906 putative ligand binding site [chemical binding]; other site 690566004907 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 690566004908 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 690566004909 Walker A/P-loop; other site 690566004910 ATP binding site [chemical binding]; other site 690566004911 Q-loop/lid; other site 690566004912 ABC transporter signature motif; other site 690566004913 Walker B; other site 690566004914 D-loop; other site 690566004915 H-loop/switch region; other site 690566004916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 690566004917 ABC-ATPase subunit interface; other site 690566004918 dimer interface [polypeptide binding]; other site 690566004919 putative PBP binding regions; other site 690566004920 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 690566004921 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 690566004922 intersubunit interface [polypeptide binding]; other site 690566004923 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 690566004924 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566004925 N-terminal plug; other site 690566004926 ligand-binding site [chemical binding]; other site 690566004927 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 690566004928 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 690566004929 GTP binding site; other site 690566004930 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 690566004931 active site 690566004932 SAM binding site [chemical binding]; other site 690566004933 homodimer interface [polypeptide binding]; other site 690566004934 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 690566004935 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 690566004936 [4Fe-4S] binding site [ion binding]; other site 690566004937 molybdopterin cofactor binding site; other site 690566004938 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 690566004939 molybdopterin cofactor binding site; other site 690566004940 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 690566004941 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 690566004942 [2Fe-2S] cluster binding site [ion binding]; other site 690566004943 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 690566004944 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566004945 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 690566004946 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 690566004947 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 690566004948 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 690566004949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566004950 putative substrate translocation pore; other site 690566004951 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 690566004952 NMT1-like family; Region: NMT1_2; pfam13379 690566004953 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 690566004954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 690566004955 active site 690566004956 phosphorylation site [posttranslational modification] 690566004957 intermolecular recognition site; other site 690566004958 ANTAR domain; Region: ANTAR; pfam03861 690566004959 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 690566004960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566004961 putative substrate translocation pore; other site 690566004962 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 690566004963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566004964 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566004965 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566004966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566004967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566004968 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 690566004969 Response regulator receiver domain; Region: Response_reg; pfam00072 690566004970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566004971 active site 690566004972 phosphorylation site [posttranslational modification] 690566004973 intermolecular recognition site; other site 690566004974 dimerization interface [polypeptide binding]; other site 690566004975 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 690566004976 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 690566004977 Cl binding site [ion binding]; other site 690566004978 oligomer interface [polypeptide binding]; other site 690566004979 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 690566004980 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 690566004981 diaminopimelate decarboxylase; Region: lysA; TIGR01048 690566004982 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 690566004983 active site 690566004984 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566004985 substrate binding site [chemical binding]; other site 690566004986 catalytic residues [active] 690566004987 dimer interface [polypeptide binding]; other site 690566004988 argininosuccinate lyase; Provisional; Region: PRK00855 690566004989 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 690566004990 active sites [active] 690566004991 tetramer interface [polypeptide binding]; other site 690566004992 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 690566004993 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 690566004994 catalytic residues [active] 690566004995 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566004996 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566004997 N-terminal plug; other site 690566004998 ligand-binding site [chemical binding]; other site 690566004999 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 690566005000 homotrimer interaction site [polypeptide binding]; other site 690566005001 putative active site [active] 690566005002 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 690566005003 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 690566005004 glutamine binding [chemical binding]; other site 690566005005 catalytic triad [active] 690566005006 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 690566005007 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 690566005008 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 690566005009 active site 690566005010 ribulose/triose binding site [chemical binding]; other site 690566005011 phosphate binding site [ion binding]; other site 690566005012 substrate (anthranilate) binding pocket [chemical binding]; other site 690566005013 product (indole) binding pocket [chemical binding]; other site 690566005014 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 690566005015 trimer interface [polypeptide binding]; other site 690566005016 dimer interface [polypeptide binding]; other site 690566005017 putative active site [active] 690566005018 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 690566005019 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 690566005020 dimer interface [polypeptide binding]; other site 690566005021 putative functional site; other site 690566005022 putative MPT binding site; other site 690566005023 LexA repressor; Validated; Region: PRK00215 690566005024 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 690566005025 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 690566005026 Catalytic site [active] 690566005027 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 690566005028 Competence protein; Region: Competence; pfam03772 690566005029 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 690566005030 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566005031 active site 690566005032 HIGH motif; other site 690566005033 nucleotide binding site [chemical binding]; other site 690566005034 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 690566005035 active site 690566005036 KMSKS motif; other site 690566005037 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 690566005038 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 690566005039 dimer interface [polypeptide binding]; other site 690566005040 active site 690566005041 citrylCoA binding site [chemical binding]; other site 690566005042 NADH binding [chemical binding]; other site 690566005043 cationic pore residues; other site 690566005044 oxalacetate/citrate binding site [chemical binding]; other site 690566005045 coenzyme A binding site [chemical binding]; other site 690566005046 catalytic triad [active] 690566005047 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 690566005048 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 690566005049 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 690566005050 active site 690566005051 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 690566005052 excinuclease ABC subunit B; Provisional; Region: PRK05298 690566005053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566005054 ATP binding site [chemical binding]; other site 690566005055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566005056 nucleotide binding region [chemical binding]; other site 690566005057 ATP-binding site [chemical binding]; other site 690566005058 Ultra-violet resistance protein B; Region: UvrB; pfam12344 690566005059 UvrB/uvrC motif; Region: UVR; pfam02151 690566005060 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 690566005061 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 690566005062 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 690566005063 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566005064 PAS domain; Region: PAS_9; pfam13426 690566005065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566005066 putative active site [active] 690566005067 heme pocket [chemical binding]; other site 690566005068 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566005069 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566005070 metal binding site [ion binding]; metal-binding site 690566005071 active site 690566005072 I-site; other site 690566005073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566005074 PilZ domain; Region: PilZ; pfam07238 690566005075 DNA polymerase III subunit beta; Validated; Region: PRK05643 690566005076 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 690566005077 putative DNA binding surface [nucleotide binding]; other site 690566005078 dimer interface [polypeptide binding]; other site 690566005079 beta-clamp/clamp loader binding surface; other site 690566005080 beta-clamp/translesion DNA polymerase binding surface; other site 690566005081 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 690566005082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566005083 FeS/SAM binding site; other site 690566005084 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 690566005085 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 690566005086 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 690566005087 Moco binding site; other site 690566005088 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 690566005089 metal coordination site [ion binding]; other site 690566005090 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 690566005091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566005092 S-adenosylmethionine binding site [chemical binding]; other site 690566005093 Predicted membrane protein [Function unknown]; Region: COG3766 690566005094 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 690566005095 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 690566005096 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 690566005097 Protein of unknown function (DUF3297); Region: DUF3297; pfam11730 690566005098 Surface antigen [General function prediction only]; Region: COG3942 690566005099 CHAP domain; Region: CHAP; cl17642 690566005100 CHAP domain; Region: CHAP; cl17642 690566005101 recombination protein F; Reviewed; Region: recF; PRK00064 690566005102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566005103 Walker A/P-loop; other site 690566005104 ATP binding site [chemical binding]; other site 690566005105 Q-loop/lid; other site 690566005106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566005107 ABC transporter signature motif; other site 690566005108 Walker B; other site 690566005109 D-loop; other site 690566005110 H-loop/switch region; other site 690566005111 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 690566005112 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 690566005113 catalytic triad [active] 690566005114 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 690566005115 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 690566005116 putative active site pocket [active] 690566005117 dimerization interface [polypeptide binding]; other site 690566005118 putative catalytic residue [active] 690566005119 PspC domain; Region: PspC; pfam04024 690566005120 Protein of unknown function DUF72; Region: DUF72; pfam01904 690566005121 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 690566005122 active site 690566005123 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 690566005124 DHH family; Region: DHH; pfam01368 690566005125 DHHA1 domain; Region: DHHA1; pfam02272 690566005126 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 690566005127 Surface antigen; Region: Bac_surface_Ag; pfam01103 690566005128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 690566005129 Family of unknown function (DUF490); Region: DUF490; pfam04357 690566005130 recombinase A; Provisional; Region: recA; PRK09354 690566005131 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 690566005132 hexamer interface [polypeptide binding]; other site 690566005133 Walker A motif; other site 690566005134 ATP binding site [chemical binding]; other site 690566005135 Walker B motif; other site 690566005136 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566005137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566005138 active site 690566005139 phosphorylation site [posttranslational modification] 690566005140 intermolecular recognition site; other site 690566005141 dimerization interface [polypeptide binding]; other site 690566005142 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 690566005143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566005144 dimer interface [polypeptide binding]; other site 690566005145 phosphorylation site [posttranslational modification] 690566005146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566005147 ATP binding site [chemical binding]; other site 690566005148 Mg2+ binding site [ion binding]; other site 690566005149 G-X-G motif; other site 690566005150 Response regulator receiver domain; Region: Response_reg; pfam00072 690566005151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566005152 active site 690566005153 phosphorylation site [posttranslational modification] 690566005154 intermolecular recognition site; other site 690566005155 dimerization interface [polypeptide binding]; other site 690566005156 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 690566005157 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 690566005158 SmpB-tmRNA interface; other site 690566005159 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 690566005160 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 690566005161 dimer interface [polypeptide binding]; other site 690566005162 active site 690566005163 catalytic residue [active] 690566005164 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 690566005165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566005166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566005167 catalytic residue [active] 690566005168 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 690566005169 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 690566005170 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 690566005171 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 690566005172 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 690566005173 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 690566005174 dimer interface [polypeptide binding]; other site 690566005175 anticodon binding site; other site 690566005176 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 690566005177 homodimer interface [polypeptide binding]; other site 690566005178 motif 1; other site 690566005179 active site 690566005180 motif 2; other site 690566005181 GAD domain; Region: GAD; pfam02938 690566005182 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 690566005183 active site 690566005184 motif 3; other site 690566005185 ribonuclease D; Region: rnd; TIGR01388 690566005186 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 690566005187 catalytic site [active] 690566005188 putative active site [active] 690566005189 putative substrate binding site [chemical binding]; other site 690566005190 HRDC domain; Region: HRDC; pfam00570 690566005191 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 690566005192 Domain of unknown function (DU1801); Region: DUF1801; cl17490 690566005193 Bacterial PH domain; Region: DUF304; pfam03703 690566005194 putative addiction module antidote; Region: doc_partner; TIGR02609 690566005195 Fic/DOC family; Region: Fic; cl00960 690566005196 GTP-binding protein LepA; Provisional; Region: PRK05433 690566005197 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 690566005198 G1 box; other site 690566005199 putative GEF interaction site [polypeptide binding]; other site 690566005200 GTP/Mg2+ binding site [chemical binding]; other site 690566005201 Switch I region; other site 690566005202 G2 box; other site 690566005203 G3 box; other site 690566005204 Switch II region; other site 690566005205 G4 box; other site 690566005206 G5 box; other site 690566005207 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 690566005208 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 690566005209 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 690566005210 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 690566005211 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 690566005212 hydrophobic ligand binding site; other site 690566005213 adenylate kinase; Reviewed; Region: adk; PRK00279 690566005214 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 690566005215 AMP-binding site [chemical binding]; other site 690566005216 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 690566005217 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 690566005218 SecY translocase; Region: SecY; pfam00344 690566005219 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 690566005220 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 690566005221 23S rRNA binding site [nucleotide binding]; other site 690566005222 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 690566005223 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 690566005224 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 690566005225 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 690566005226 5S rRNA interface [nucleotide binding]; other site 690566005227 23S rRNA interface [nucleotide binding]; other site 690566005228 L5 interface [polypeptide binding]; other site 690566005229 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 690566005230 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 690566005231 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 690566005232 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 690566005233 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 690566005234 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 690566005235 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 690566005236 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 690566005237 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 690566005238 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 690566005239 RNA binding site [nucleotide binding]; other site 690566005240 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 690566005241 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 690566005242 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 690566005243 23S rRNA interface [nucleotide binding]; other site 690566005244 putative translocon interaction site; other site 690566005245 signal recognition particle (SRP54) interaction site; other site 690566005246 L23 interface [polypeptide binding]; other site 690566005247 trigger factor interaction site; other site 690566005248 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 690566005249 23S rRNA interface [nucleotide binding]; other site 690566005250 5S rRNA interface [nucleotide binding]; other site 690566005251 putative antibiotic binding site [chemical binding]; other site 690566005252 L25 interface [polypeptide binding]; other site 690566005253 L27 interface [polypeptide binding]; other site 690566005254 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 690566005255 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 690566005256 G-X-X-G motif; other site 690566005257 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 690566005258 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 690566005259 putative translocon binding site; other site 690566005260 protein-rRNA interface [nucleotide binding]; other site 690566005261 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 690566005262 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 690566005263 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 690566005264 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 690566005265 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 690566005266 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 690566005267 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 690566005268 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 690566005269 elongation factor Tu; Reviewed; Region: PRK00049 690566005270 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 690566005271 G1 box; other site 690566005272 GEF interaction site [polypeptide binding]; other site 690566005273 GTP/Mg2+ binding site [chemical binding]; other site 690566005274 Switch I region; other site 690566005275 G2 box; other site 690566005276 G3 box; other site 690566005277 Switch II region; other site 690566005278 G4 box; other site 690566005279 G5 box; other site 690566005280 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 690566005281 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 690566005282 Antibiotic Binding Site [chemical binding]; other site 690566005283 elongation factor G; Reviewed; Region: PRK00007 690566005284 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 690566005285 G1 box; other site 690566005286 putative GEF interaction site [polypeptide binding]; other site 690566005287 GTP/Mg2+ binding site [chemical binding]; other site 690566005288 Switch I region; other site 690566005289 G2 box; other site 690566005290 G3 box; other site 690566005291 Switch II region; other site 690566005292 G4 box; other site 690566005293 G5 box; other site 690566005294 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 690566005295 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 690566005296 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 690566005297 30S ribosomal protein S7; Validated; Region: PRK05302 690566005298 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 690566005299 S17 interaction site [polypeptide binding]; other site 690566005300 S8 interaction site; other site 690566005301 16S rRNA interaction site [nucleotide binding]; other site 690566005302 streptomycin interaction site [chemical binding]; other site 690566005303 23S rRNA interaction site [nucleotide binding]; other site 690566005304 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 690566005305 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566005306 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566005307 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 690566005308 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 690566005309 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 690566005310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005311 Walker A motif; other site 690566005312 ATP binding site [chemical binding]; other site 690566005313 Walker B motif; other site 690566005314 arginine finger; other site 690566005315 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 690566005316 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 690566005317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566005318 S-adenosylmethionine binding site [chemical binding]; other site 690566005319 exopolyphosphatase; Region: exo_poly_only; TIGR03706 690566005320 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 690566005321 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182 690566005322 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 690566005323 Protein export membrane protein; Region: SecD_SecF; pfam02355 690566005324 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 690566005325 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 690566005326 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 690566005327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 690566005328 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 690566005329 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 690566005330 phosphate binding site [ion binding]; other site 690566005331 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 690566005332 Amidase; Region: Amidase; cl11426 690566005333 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566005334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566005335 N-terminal plug; other site 690566005336 ligand-binding site [chemical binding]; other site 690566005337 AMP-binding domain protein; Validated; Region: PRK08315 690566005338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566005339 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566005340 acyl-activating enzyme (AAE) consensus motif; other site 690566005341 putative AMP binding site [chemical binding]; other site 690566005342 putative active site [active] 690566005343 putative CoA binding site [chemical binding]; other site 690566005344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566005345 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 690566005346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566005347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566005348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566005349 dimerization interface [polypeptide binding]; other site 690566005350 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 690566005351 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 690566005352 homotrimer interaction site [polypeptide binding]; other site 690566005353 putative active site [active] 690566005354 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 690566005355 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566005356 NAD(P) binding site [chemical binding]; other site 690566005357 catalytic residues [active] 690566005358 acetylornithine deacetylase; Provisional; Region: PRK07522 690566005359 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 690566005360 metal binding site [ion binding]; metal-binding site 690566005361 putative dimer interface [polypeptide binding]; other site 690566005362 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 690566005363 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 690566005364 FMN binding site [chemical binding]; other site 690566005365 active site 690566005366 homodimer interface [polypeptide binding]; other site 690566005367 putative catalytic residue [active] 690566005368 4Fe-4S cluster binding site [ion binding]; other site 690566005369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566005370 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 690566005371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566005372 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566005373 putative substrate translocation pore; other site 690566005374 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566005375 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566005376 N-terminal plug; other site 690566005377 ligand-binding site [chemical binding]; other site 690566005378 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566005379 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566005380 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 690566005381 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 690566005382 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 690566005383 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 690566005384 MFS/sugar transport protein; Region: MFS_2; pfam13347 690566005385 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 690566005386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 690566005387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 690566005388 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 690566005389 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 690566005390 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 690566005391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566005392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566005393 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 690566005394 putative effector binding pocket; other site 690566005395 dimerization interface [polypeptide binding]; other site 690566005396 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 690566005397 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 690566005398 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 690566005399 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 690566005400 30S ribosomal protein S13; Region: bact_S13; TIGR03631 690566005401 30S ribosomal protein S11; Validated; Region: PRK05309 690566005402 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 690566005403 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 690566005404 alphaNTD homodimer interface [polypeptide binding]; other site 690566005405 alphaNTD - beta interaction site [polypeptide binding]; other site 690566005406 alphaNTD - beta' interaction site [polypeptide binding]; other site 690566005407 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 690566005408 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 690566005409 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 690566005410 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566005411 GMP synthase; Reviewed; Region: guaA; PRK00074 690566005412 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 690566005413 AMP/PPi binding site [chemical binding]; other site 690566005414 candidate oxyanion hole; other site 690566005415 catalytic triad [active] 690566005416 potential glutamine specificity residues [chemical binding]; other site 690566005417 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 690566005418 ATP Binding subdomain [chemical binding]; other site 690566005419 Ligand Binding sites [chemical binding]; other site 690566005420 Dimerization subdomain; other site 690566005421 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566005422 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566005423 classical (c) SDRs; Region: SDR_c; cd05233 690566005424 NAD(P) binding site [chemical binding]; other site 690566005425 active site 690566005426 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 690566005427 putative active site [active] 690566005428 putative substrate binding site [chemical binding]; other site 690566005429 ATP binding site [chemical binding]; other site 690566005430 Phosphotransferase enzyme family; Region: APH; pfam01636 690566005431 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 690566005432 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 690566005433 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 690566005434 hypothetical protein; Provisional; Region: PRK08912 690566005435 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566005436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566005437 homodimer interface [polypeptide binding]; other site 690566005438 catalytic residue [active] 690566005439 RDD family; Region: RDD; pfam06271 690566005440 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 690566005441 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 690566005442 Protein of unknown function DUF58; Region: DUF58; pfam01882 690566005443 MoxR-like ATPases [General function prediction only]; Region: COG0714 690566005444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005445 Walker A motif; other site 690566005446 ATP binding site [chemical binding]; other site 690566005447 Walker B motif; other site 690566005448 arginine finger; other site 690566005449 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 690566005450 Protein of unknown function (DUF975); Region: DUF975; cl10504 690566005451 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 690566005452 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 690566005453 active site 690566005454 dimer interface [polypeptide binding]; other site 690566005455 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 690566005456 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 690566005457 active site 690566005458 FMN binding site [chemical binding]; other site 690566005459 substrate binding site [chemical binding]; other site 690566005460 3Fe-4S cluster binding site [ion binding]; other site 690566005461 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 690566005462 domain interface; other site 690566005463 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 690566005464 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 690566005465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566005466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566005467 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 690566005468 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 690566005469 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 690566005470 putative NAD(P) binding site [chemical binding]; other site 690566005471 active site 690566005472 Predicted membrane protein [Function unknown]; Region: COG2119 690566005473 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 690566005474 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 690566005475 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 690566005476 diiron binding motif [ion binding]; other site 690566005477 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 690566005478 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 690566005479 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 690566005480 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 690566005481 protein binding site [polypeptide binding]; other site 690566005482 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 690566005483 Catalytic dyad [active] 690566005484 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 690566005485 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566005486 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 690566005487 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 690566005488 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 690566005489 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 690566005490 active site 690566005491 (T/H)XGH motif; other site 690566005492 RmuC family; Region: RmuC; pfam02646 690566005493 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 690566005494 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 690566005495 Walker A/P-loop; other site 690566005496 ATP binding site [chemical binding]; other site 690566005497 Q-loop/lid; other site 690566005498 ABC transporter signature motif; other site 690566005499 Walker B; other site 690566005500 D-loop; other site 690566005501 H-loop/switch region; other site 690566005502 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 690566005503 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 690566005504 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 690566005505 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 690566005506 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 690566005507 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 690566005508 homodimer interface [polypeptide binding]; other site 690566005509 substrate-cofactor binding pocket; other site 690566005510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566005511 catalytic residue [active] 690566005512 Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240 690566005513 MarR family; Region: MarR_2; cl17246 690566005514 HNH endonuclease; Region: HNH_2; pfam13391 690566005515 DGQHR domain; Region: DGQHR; TIGR03187 690566005516 DNA-sulfur modification-associated; Region: DndB; cl17621 690566005517 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 690566005518 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 690566005519 DGQHR domain; Region: DGQHR; TIGR03187 690566005520 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 690566005521 active site 690566005522 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 690566005523 Ligand Binding Site [chemical binding]; other site 690566005524 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 690566005525 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 690566005526 Part of AAA domain; Region: AAA_19; pfam13245 690566005527 Family description; Region: UvrD_C_2; pfam13538 690566005528 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 690566005529 putative active site [active] 690566005530 catalytic site [active] 690566005531 Zinc-finger domain; Region: zf-CHCC; pfam10276 690566005532 protease TldD; Provisional; Region: tldD; PRK10735 690566005533 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 690566005534 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 690566005535 Nitrogen regulatory protein P-II; Region: P-II; smart00938 690566005536 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 690566005537 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 690566005538 active site lid residues [active] 690566005539 substrate binding pocket [chemical binding]; other site 690566005540 catalytic residues [active] 690566005541 substrate-Mg2+ binding site; other site 690566005542 aspartate-rich region 1; other site 690566005543 aspartate-rich region 2; other site 690566005544 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 690566005545 phytoene desaturase; Region: crtI_fam; TIGR02734 690566005546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566005547 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 690566005548 lycopene cyclase; Region: lycopene_cycl; TIGR01789 690566005549 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 690566005550 putative metal binding site [ion binding]; other site 690566005551 putative homodimer interface [polypeptide binding]; other site 690566005552 putative homotetramer interface [polypeptide binding]; other site 690566005553 putative homodimer-homodimer interface [polypeptide binding]; other site 690566005554 putative allosteric switch controlling residues; other site 690566005555 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 690566005556 HI0933-like protein; Region: HI0933_like; pfam03486 690566005557 Putative phosphatase (DUF442); Region: DUF442; cl17385 690566005558 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 690566005559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566005560 ATP binding site [chemical binding]; other site 690566005561 putative Mg++ binding site [ion binding]; other site 690566005562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566005563 nucleotide binding region [chemical binding]; other site 690566005564 ATP-binding site [chemical binding]; other site 690566005565 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 690566005566 HRDC domain; Region: HRDC; pfam00570 690566005567 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 690566005568 Beta-lactamase; Region: Beta-lactamase; pfam00144 690566005569 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 690566005570 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 690566005571 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 690566005572 Tetramer interface [polypeptide binding]; other site 690566005573 active site 690566005574 FMN-binding site [chemical binding]; other site 690566005575 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 690566005576 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 690566005577 NAD binding site [chemical binding]; other site 690566005578 homotetramer interface [polypeptide binding]; other site 690566005579 homodimer interface [polypeptide binding]; other site 690566005580 substrate binding site [chemical binding]; other site 690566005581 active site 690566005582 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 690566005583 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 690566005584 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 690566005585 HSP70 interaction site [polypeptide binding]; other site 690566005586 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 690566005587 substrate binding site [polypeptide binding]; other site 690566005588 dimer interface [polypeptide binding]; other site 690566005589 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 690566005590 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 690566005591 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 690566005592 Transposase; Region: HTH_Tnp_1; cl17663 690566005593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 690566005594 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 690566005595 HTH-like domain; Region: HTH_21; pfam13276 690566005596 Integrase core domain; Region: rve; pfam00665 690566005597 Integrase core domain; Region: rve_3; pfam13683 690566005598 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 690566005599 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 690566005600 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 690566005601 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 690566005602 GDP-binding site [chemical binding]; other site 690566005603 ACT binding site; other site 690566005604 IMP binding site; other site 690566005605 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 690566005606 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 690566005607 motif 1; other site 690566005608 dimer interface [polypeptide binding]; other site 690566005609 active site 690566005610 motif 2; other site 690566005611 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 690566005612 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 690566005613 ligand binding site [chemical binding]; other site 690566005614 NAD binding site [chemical binding]; other site 690566005615 dimerization interface [polypeptide binding]; other site 690566005616 catalytic site [active] 690566005617 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 690566005618 putative L-serine binding site [chemical binding]; other site 690566005619 phosphoserine aminotransferase; Provisional; Region: PRK03080 690566005620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566005621 catalytic residue [active] 690566005622 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 690566005623 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 690566005624 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 690566005625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566005626 motif II; other site 690566005627 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 690566005628 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 690566005629 trimer interface [polypeptide binding]; other site 690566005630 active site 690566005631 substrate binding site [chemical binding]; other site 690566005632 CoA binding site [chemical binding]; other site 690566005633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 690566005634 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 690566005635 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 690566005636 Walker A/P-loop; other site 690566005637 ATP binding site [chemical binding]; other site 690566005638 Q-loop/lid; other site 690566005639 ABC transporter signature motif; other site 690566005640 Walker B; other site 690566005641 D-loop; other site 690566005642 H-loop/switch region; other site 690566005643 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 690566005644 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 690566005645 active site 690566005646 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 690566005647 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566005648 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 690566005649 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 690566005650 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 690566005651 active site 690566005652 Phasin protein; Region: Phasin_2; pfam09361 690566005653 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 690566005654 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 690566005655 aminotransferase; Validated; Region: PRK09148 690566005656 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566005657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566005658 homodimer interface [polypeptide binding]; other site 690566005659 catalytic residue [active] 690566005660 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 690566005661 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 690566005662 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566005663 catalytic loop [active] 690566005664 iron binding site [ion binding]; other site 690566005665 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 690566005666 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 690566005667 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 690566005668 putative active site [active] 690566005669 metal binding site [ion binding]; metal-binding site 690566005670 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 690566005671 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 690566005672 cofactor binding site; other site 690566005673 DNA binding site [nucleotide binding] 690566005674 substrate interaction site [chemical binding]; other site 690566005675 Catalytic GIY-YIG domain of type II restriction endonucleases R.Eco29kI, R.Cfr42I, and similar proteins; Region: GIY-YIG_RE_Eco29kI_like; cd10435 690566005676 GIY-YIG motif/motif A; other site 690566005677 active site 690566005678 DNA binding site [nucleotide binding] 690566005679 homodimer interface [polypeptide binding]; other site 690566005680 putative metal binding site [ion binding]; other site 690566005681 AAA domain; Region: AAA_13; pfam13166 690566005682 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 690566005683 polymerase nucleotide-binding site; other site 690566005684 DNA-binding residues [nucleotide binding]; DNA binding site 690566005685 nucleotide binding site [chemical binding]; other site 690566005686 primase nucleotide-binding site [nucleotide binding]; other site 690566005687 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 690566005688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 690566005689 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566005690 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 690566005691 active site 690566005692 DNA binding site [nucleotide binding] 690566005693 Int/Topo IB signature motif; other site 690566005694 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 690566005695 active site 690566005696 Zn binding site [ion binding]; other site 690566005697 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 690566005698 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566005699 N-terminal plug; other site 690566005700 ligand-binding site [chemical binding]; other site 690566005701 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 690566005702 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 690566005703 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 690566005704 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 690566005705 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 690566005706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566005707 catalytic loop [active] 690566005708 iron binding site [ion binding]; other site 690566005709 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 690566005710 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 690566005711 mismatch recognition site; other site 690566005712 additional DNA contacts [nucleotide binding]; other site 690566005713 active site 690566005714 zinc binding site [ion binding]; other site 690566005715 DNA intercalation site [nucleotide binding]; other site 690566005716 Uncharacterized conserved protein [Function unknown]; Region: COG1479 690566005717 Protein of unknown function DUF262; Region: DUF262; pfam03235 690566005718 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 690566005719 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 690566005720 cofactor binding site; other site 690566005721 DNA binding site [nucleotide binding] 690566005722 substrate interaction site [chemical binding]; other site 690566005723 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566005724 active site 690566005725 DNA binding site [nucleotide binding] 690566005726 Int/Topo IB signature motif; other site 690566005727 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 690566005728 ThiC-associated domain; Region: ThiC-associated; pfam13667 690566005729 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 690566005730 Cytochrome P450; Region: p450; cl12078 690566005731 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566005732 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 690566005733 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 690566005734 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 690566005735 putative catalytic cysteine [active] 690566005736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 690566005737 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 690566005738 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 690566005739 Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933 690566005740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005741 Walker A motif; other site 690566005742 ATP binding site [chemical binding]; other site 690566005743 Walker B motif; other site 690566005744 arginine finger; other site 690566005745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005746 Walker A motif; other site 690566005747 ATP binding site [chemical binding]; other site 690566005748 Walker B motif; other site 690566005749 arginine finger; other site 690566005750 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 690566005751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566005752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566005753 dimerization interface [polypeptide binding]; other site 690566005754 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566005755 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566005756 metal binding site [ion binding]; metal-binding site 690566005757 active site 690566005758 I-site; other site 690566005759 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566005760 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 690566005761 C-terminal domain interface [polypeptide binding]; other site 690566005762 GSH binding site (G-site) [chemical binding]; other site 690566005763 dimer interface [polypeptide binding]; other site 690566005764 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 690566005765 N-terminal domain interface [polypeptide binding]; other site 690566005766 dimer interface [polypeptide binding]; other site 690566005767 substrate binding pocket (H-site) [chemical binding]; other site 690566005768 acetyl-CoA synthetase; Provisional; Region: PRK00174 690566005769 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 690566005770 active site 690566005771 CoA binding site [chemical binding]; other site 690566005772 acyl-activating enzyme (AAE) consensus motif; other site 690566005773 AMP binding site [chemical binding]; other site 690566005774 acetate binding site [chemical binding]; other site 690566005775 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566005776 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 690566005777 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 690566005778 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 690566005779 homodimer interface [polypeptide binding]; other site 690566005780 substrate-cofactor binding pocket; other site 690566005781 catalytic residue [active] 690566005782 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 690566005783 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 690566005784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566005785 catalytic residue [active] 690566005786 EamA-like transporter family; Region: EamA; pfam00892 690566005787 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 690566005788 EamA-like transporter family; Region: EamA; pfam00892 690566005789 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566005790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566005791 NAD(P) binding site [chemical binding]; other site 690566005792 active site 690566005793 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 690566005794 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 690566005795 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 690566005796 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 690566005797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566005798 catalytic residue [active] 690566005799 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 690566005800 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 690566005801 FeS assembly ATPase SufC; Region: sufC; TIGR01978 690566005802 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 690566005803 Walker A/P-loop; other site 690566005804 ATP binding site [chemical binding]; other site 690566005805 Q-loop/lid; other site 690566005806 ABC transporter signature motif; other site 690566005807 Walker B; other site 690566005808 D-loop; other site 690566005809 H-loop/switch region; other site 690566005810 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 690566005811 putative ABC transporter; Region: ycf24; CHL00085 690566005812 Rrf2 family protein; Region: rrf2_super; TIGR00738 690566005813 Transcriptional regulator; Region: Rrf2; pfam02082 690566005814 Transcriptional regulator; Region: Rrf2; cl17282 690566005815 Helix-turn-helix domain; Region: HTH_18; pfam12833 690566005816 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 690566005817 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 690566005818 quinone interaction residues [chemical binding]; other site 690566005819 active site 690566005820 catalytic residues [active] 690566005821 FMN binding site [chemical binding]; other site 690566005822 substrate binding site [chemical binding]; other site 690566005823 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 690566005824 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 690566005825 Fe-S metabolism associated domain; Region: SufE; cl00951 690566005826 phage shock protein C; Region: phageshock_pspC; TIGR02978 690566005827 PspC domain; Region: PspC; pfam04024 690566005828 Phage shock protein B; Region: PspB; cl05946 690566005829 phage shock protein A; Region: phageshock_pspA; TIGR02977 690566005830 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 690566005831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005832 Walker A motif; other site 690566005833 ATP binding site [chemical binding]; other site 690566005834 Walker B motif; other site 690566005835 arginine finger; other site 690566005836 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 690566005837 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 690566005838 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566005839 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566005840 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 690566005841 active site 690566005842 TolQ protein; Region: tolQ; TIGR02796 690566005843 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 690566005844 TolR protein; Region: tolR; TIGR02801 690566005845 Gram-negative bacterial tonB protein; Region: TonB; cl10048 690566005846 translocation protein TolB; Provisional; Region: tolB; PRK05137 690566005847 TolB amino-terminal domain; Region: TolB_N; pfam04052 690566005848 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566005849 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566005850 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566005851 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566005852 ligand binding site [chemical binding]; other site 690566005853 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 690566005854 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 690566005855 Predicted membrane protein [Function unknown]; Region: COG2364 690566005856 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 690566005857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566005858 DNA-binding site [nucleotide binding]; DNA binding site 690566005859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566005860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566005861 homodimer interface [polypeptide binding]; other site 690566005862 catalytic residue [active] 690566005863 Peptidase family M48; Region: Peptidase_M48; cl12018 690566005864 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 690566005865 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 690566005866 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 690566005867 active site 690566005868 tetramer interface; other site 690566005869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859 690566005870 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 690566005871 dimer interface [polypeptide binding]; other site 690566005872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566005873 active site 690566005874 metal binding site [ion binding]; metal-binding site 690566005875 glutathione binding site [chemical binding]; other site 690566005876 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 690566005877 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 690566005878 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 690566005879 acyl-activating enzyme (AAE) consensus motif; other site 690566005880 putative AMP binding site [chemical binding]; other site 690566005881 putative active site [active] 690566005882 putative CoA binding site [chemical binding]; other site 690566005883 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 690566005884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005885 Walker A motif; other site 690566005886 ATP binding site [chemical binding]; other site 690566005887 Walker B motif; other site 690566005888 arginine finger; other site 690566005889 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 690566005890 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 690566005891 RuvA N terminal domain; Region: RuvA_N; pfam01330 690566005892 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 690566005893 Phospholipid methyltransferase; Region: PEMT; cl17370 690566005894 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 690566005895 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 690566005896 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 690566005897 UbiA prenyltransferase family; Region: UbiA; pfam01040 690566005898 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 690566005899 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 690566005900 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 690566005901 putative active site [active] 690566005902 putative active site [active] 690566005903 catalytic site [active] 690566005904 catalytic site [active] 690566005905 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 690566005906 putative active site [active] 690566005907 catalytic site [active] 690566005908 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 690566005909 AAA domain; Region: AAA_23; pfam13476 690566005910 Walker A/P-loop; other site 690566005911 ATP binding site [chemical binding]; other site 690566005912 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 690566005913 ABC transporter signature motif; other site 690566005914 Walker B; other site 690566005915 D-loop; other site 690566005916 H-loop/switch region; other site 690566005917 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 690566005918 Thioredoxin; Region: Thioredoxin_4; pfam13462 690566005919 Thioredoxin; Region: Thioredoxin_4; pfam13462 690566005920 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 690566005921 Protein of unknown function (DUF721); Region: DUF721; pfam05258 690566005922 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 690566005923 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 690566005924 minor groove reading motif; other site 690566005925 helix-hairpin-helix signature motif; other site 690566005926 substrate binding pocket [chemical binding]; other site 690566005927 active site 690566005928 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 690566005929 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 690566005930 DNA binding and oxoG recognition site [nucleotide binding] 690566005931 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 690566005932 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 690566005933 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 690566005934 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 690566005935 putative NADH binding site [chemical binding]; other site 690566005936 putative active site [active] 690566005937 nudix motif; other site 690566005938 putative metal binding site [ion binding]; other site 690566005939 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 690566005940 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 690566005941 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 690566005942 active site 690566005943 Uncharacterized conserved protein [Function unknown]; Region: COG3743 690566005944 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 690566005945 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 690566005946 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 690566005947 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 690566005948 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 690566005949 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 690566005950 generic binding surface II; other site 690566005951 generic binding surface I; other site 690566005952 Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866 690566005953 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566005954 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566005955 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566005956 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566005957 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 690566005958 Clp amino terminal domain; Region: Clp_N; pfam02861 690566005959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005960 Walker A motif; other site 690566005961 ATP binding site [chemical binding]; other site 690566005962 Walker B motif; other site 690566005963 arginine finger; other site 690566005964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566005965 Walker A motif; other site 690566005966 ATP binding site [chemical binding]; other site 690566005967 Walker B motif; other site 690566005968 arginine finger; other site 690566005969 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 690566005970 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 690566005971 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 690566005972 PA/protease or protease-like domain interface [polypeptide binding]; other site 690566005973 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 690566005974 Peptidase family M28; Region: Peptidase_M28; pfam04389 690566005975 metal binding site [ion binding]; metal-binding site 690566005976 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 690566005977 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 690566005978 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 690566005979 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 690566005980 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 690566005981 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 690566005982 transcriptional regulator SlyA; Provisional; Region: PRK03573 690566005983 MarR family; Region: MarR_2; pfam12802 690566005984 Fusaric acid resistance protein family; Region: FUSC; pfam04632 690566005985 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 690566005986 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 690566005987 HlyD family secretion protein; Region: HlyD; pfam00529 690566005988 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566005989 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566005990 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566005991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566005992 binding surface 690566005993 Tetratricopeptide repeat; Region: TPR_16; pfam13432 690566005994 TPR motif; other site 690566005995 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566005996 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566005997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 690566005998 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 690566005999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566006000 classical (c) SDRs; Region: SDR_c; cd05233 690566006001 NAD(P) binding site [chemical binding]; other site 690566006002 active site 690566006003 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566006004 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566006005 active site 690566006006 enoyl-CoA hydratase; Provisional; Region: PRK06688 690566006007 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566006008 substrate binding site [chemical binding]; other site 690566006009 oxyanion hole (OAH) forming residues; other site 690566006010 trimer interface [polypeptide binding]; other site 690566006011 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 690566006012 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566006013 dimer interface [polypeptide binding]; other site 690566006014 active site 690566006015 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 690566006016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566006017 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566006018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566006019 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566006020 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566006021 active site 690566006022 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566006023 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566006024 active site 690566006025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566006026 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 690566006027 substrate binding site [chemical binding]; other site 690566006028 oxyanion hole (OAH) forming residues; other site 690566006029 trimer interface [polypeptide binding]; other site 690566006030 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566006031 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566006032 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566006033 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566006034 Cytochrome P450; Region: p450; cl12078 690566006035 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 690566006036 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566006037 active site 690566006038 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566006039 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566006040 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566006041 N-terminal plug; other site 690566006042 ligand-binding site [chemical binding]; other site 690566006043 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 690566006044 putative active site [active] 690566006045 putative catalytic site [active] 690566006046 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 690566006047 putative active site [active] 690566006048 putative catalytic site [active] 690566006049 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566006050 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 690566006051 NAD(P) binding site [chemical binding]; other site 690566006052 catalytic residues [active] 690566006053 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 690566006054 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566006055 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566006056 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566006057 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566006058 active site 690566006059 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566006060 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566006061 substrate binding site [chemical binding]; other site 690566006062 oxyanion hole (OAH) forming residues; other site 690566006063 trimer interface [polypeptide binding]; other site 690566006064 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 690566006065 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 690566006066 molybdopterin cofactor binding site; other site 690566006067 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 690566006068 molybdopterin cofactor binding site; other site 690566006069 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 690566006070 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566006071 NAD(P) binding site [chemical binding]; other site 690566006072 catalytic residues [active] 690566006073 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 690566006074 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 690566006075 Trp docking motif [polypeptide binding]; other site 690566006076 active site 690566006077 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566006078 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 690566006079 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566006080 FO synthase; Reviewed; Region: fbiC; PRK09234 690566006081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566006082 FeS/SAM binding site; other site 690566006083 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 690566006084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566006085 FeS/SAM binding site; other site 690566006086 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566006087 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566006088 N-terminal plug; other site 690566006089 ligand-binding site [chemical binding]; other site 690566006090 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566006091 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 690566006092 C-terminal domain interface [polypeptide binding]; other site 690566006093 GSH binding site (G-site) [chemical binding]; other site 690566006094 dimer interface [polypeptide binding]; other site 690566006095 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 690566006096 N-terminal domain interface [polypeptide binding]; other site 690566006097 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 690566006098 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566006099 FMN binding site [chemical binding]; other site 690566006100 substrate binding site [chemical binding]; other site 690566006101 putative catalytic residue [active] 690566006102 enoyl-CoA hydratase; Provisional; Region: PRK06210 690566006103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566006104 substrate binding site [chemical binding]; other site 690566006105 oxyanion hole (OAH) forming residues; other site 690566006106 trimer interface [polypeptide binding]; other site 690566006107 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 690566006108 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566006109 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566006110 active site 690566006111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566006112 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566006113 putative substrate translocation pore; other site 690566006114 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 690566006115 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 690566006116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 690566006117 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 690566006118 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 690566006119 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 690566006120 FAD binding pocket [chemical binding]; other site 690566006121 FAD binding motif [chemical binding]; other site 690566006122 phosphate binding motif [ion binding]; other site 690566006123 beta-alpha-beta structure motif; other site 690566006124 NAD binding pocket [chemical binding]; other site 690566006125 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 690566006126 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566006127 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 690566006128 dimer interface [polypeptide binding]; other site 690566006129 active site 690566006130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566006131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566006132 active site 690566006133 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566006134 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566006135 putative DNA binding site [nucleotide binding]; other site 690566006136 putative Zn2+ binding site [ion binding]; other site 690566006137 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566006138 Helix-turn-helix domain; Region: HTH_17; cl17695 690566006139 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 690566006140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566006141 active site 690566006142 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566006143 Phosphotransferase enzyme family; Region: APH; pfam01636 690566006144 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 690566006145 putative active site [active] 690566006146 putative substrate binding site [chemical binding]; other site 690566006147 ATP binding site [chemical binding]; other site 690566006148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 690566006149 Transposase; Region: DEDD_Tnp_IS110; pfam01548 690566006150 FecR protein; Region: FecR; pfam04773 690566006151 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 690566006152 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 690566006153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566006154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566006155 DNA binding residues [nucleotide binding] 690566006156 Secretin and TonB N terminus short domain; Region: STN; smart00965 690566006157 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 690566006158 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566006159 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566006160 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 690566006161 hypothetical protein; Provisional; Region: PRK08201 690566006162 metal binding site [ion binding]; metal-binding site 690566006163 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 690566006164 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 690566006165 FMN-binding pocket [chemical binding]; other site 690566006166 flavin binding motif; other site 690566006167 phosphate binding motif [ion binding]; other site 690566006168 beta-alpha-beta structure motif; other site 690566006169 NAD binding pocket [chemical binding]; other site 690566006170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566006171 catalytic loop [active] 690566006172 iron binding site [ion binding]; other site 690566006173 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566006174 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 690566006175 iron-sulfur cluster [ion binding]; other site 690566006176 [2Fe-2S] cluster binding site [ion binding]; other site 690566006177 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 690566006178 hydrophobic ligand binding site; other site 690566006179 HipA N-terminal domain; Region: Couple_hipA; pfam13657 690566006180 HipA-like N-terminal domain; Region: HipA_N; pfam07805 690566006181 HipA-like C-terminal domain; Region: HipA_C; pfam07804 690566006182 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566006183 non-specific DNA binding site [nucleotide binding]; other site 690566006184 salt bridge; other site 690566006185 sequence-specific DNA binding site [nucleotide binding]; other site 690566006186 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 690566006187 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 690566006188 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566006189 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 690566006190 Autotransporter beta-domain; Region: Autotransporter; pfam03797 690566006191 Protein of unknown function (DUF1134); Region: DUF1134; pfam06577 690566006192 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 690566006193 active site 690566006194 DNA polymerase IV; Validated; Region: PRK02406 690566006195 DNA binding site [nucleotide binding] 690566006196 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 690566006197 Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045 690566006198 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 690566006199 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 690566006200 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566006201 extended (e) SDRs; Region: SDR_e; cd08946 690566006202 NAD(P) binding site [chemical binding]; other site 690566006203 active site 690566006204 substrate binding site [chemical binding]; other site 690566006205 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 690566006206 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 690566006207 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566006208 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 690566006209 active site 690566006210 metal binding site [ion binding]; metal-binding site 690566006211 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566006212 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 690566006213 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 690566006214 sulfotransferase; Region: PLN02164 690566006215 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 690566006216 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 690566006217 putative ADP-binding pocket [chemical binding]; other site 690566006218 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 690566006219 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566006220 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 690566006221 SLBB domain; Region: SLBB; pfam10531 690566006222 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 690566006223 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 690566006224 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 690566006225 inhibitor-cofactor binding pocket; inhibition site 690566006226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566006227 catalytic residue [active] 690566006228 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 690566006229 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 690566006230 NAD(P) binding site [chemical binding]; other site 690566006231 homodimer interface [polypeptide binding]; other site 690566006232 substrate binding site [chemical binding]; other site 690566006233 active site 690566006234 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 690566006235 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566006236 putative ADP-binding pocket [chemical binding]; other site 690566006237 Bacterial sugar transferase; Region: Bac_transf; pfam02397 690566006238 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 690566006239 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 690566006240 active site 690566006241 substrate binding site [chemical binding]; other site 690566006242 cosubstrate binding site; other site 690566006243 catalytic site [active] 690566006244 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 690566006245 active site 690566006246 hexamer interface [polypeptide binding]; other site 690566006247 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 690566006248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566006249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566006250 active site 690566006251 phosphorylation site [posttranslational modification] 690566006252 dimerization interface [polypeptide binding]; other site 690566006253 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566006254 DNA binding residues [nucleotide binding] 690566006255 dimerization interface [polypeptide binding]; other site 690566006256 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 690566006257 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 690566006258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566006259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566006260 DNA binding residues [nucleotide binding] 690566006261 dimerization interface [polypeptide binding]; other site 690566006262 Chain length determinant protein; Region: Wzz; pfam02706 690566006263 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 690566006264 Pectate lyase; Region: Pec_lyase_C; cl01593 690566006265 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 690566006266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566006267 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566006268 Ca2+ binding site [ion binding]; other site 690566006269 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566006270 Ca2+ binding site [ion binding]; other site 690566006271 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 690566006272 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 690566006273 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 690566006274 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 690566006275 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 690566006276 dimer interface [polypeptide binding]; other site 690566006277 substrate binding site [chemical binding]; other site 690566006278 phosphate binding site [ion binding]; other site 690566006279 Guanylyl transferase CofC like; Region: CofC; cl17472 690566006280 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 690566006281 Malic enzyme, N-terminal domain; Region: malic; pfam00390 690566006282 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 690566006283 putative NAD(P) binding site [chemical binding]; other site 690566006284 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 690566006285 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 690566006286 MutS domain I; Region: MutS_I; pfam01624 690566006287 MutS domain II; Region: MutS_II; pfam05188 690566006288 MutS domain III; Region: MutS_III; pfam05192 690566006289 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 690566006290 Walker A/P-loop; other site 690566006291 ATP binding site [chemical binding]; other site 690566006292 Q-loop/lid; other site 690566006293 ABC transporter signature motif; other site 690566006294 Walker B; other site 690566006295 D-loop; other site 690566006296 H-loop/switch region; other site 690566006297 PII uridylyl-transferase; Provisional; Region: PRK05092 690566006298 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 690566006299 metal binding triad; other site 690566006300 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 690566006301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 690566006302 Zn2+ binding site [ion binding]; other site 690566006303 Mg2+ binding site [ion binding]; other site 690566006304 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 690566006305 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 690566006306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 690566006307 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 690566006308 dimerization interface [polypeptide binding]; other site 690566006309 active site 690566006310 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 690566006311 putative catalytic site [active] 690566006312 putative phosphate binding site [ion binding]; other site 690566006313 active site 690566006314 metal binding site A [ion binding]; metal-binding site 690566006315 DNA binding site [nucleotide binding] 690566006316 putative AP binding site [nucleotide binding]; other site 690566006317 putative metal binding site B [ion binding]; other site 690566006318 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 690566006319 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 690566006320 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 690566006321 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 690566006322 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 690566006323 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 690566006324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566006325 Coenzyme A binding pocket [chemical binding]; other site 690566006326 EamA-like transporter family; Region: EamA; cl17759 690566006327 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 690566006328 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 690566006329 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 690566006330 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 690566006331 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 690566006332 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 690566006333 active site 690566006334 substrate binding site [chemical binding]; other site 690566006335 metal binding site [ion binding]; metal-binding site 690566006336 DnaJ chaperone protein; Provisional; Region: PTZ00100 690566006337 ATPase MipZ; Region: MipZ; pfam09140 690566006338 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566006339 P-loop; other site 690566006340 Magnesium ion binding site [ion binding]; other site 690566006341 pantoate--beta-alanine ligase; Region: panC; TIGR00018 690566006342 Pantoate-beta-alanine ligase; Region: PanC; cd00560 690566006343 active site 690566006344 ATP-binding site [chemical binding]; other site 690566006345 pantoate-binding site; other site 690566006346 HXXH motif; other site 690566006347 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 690566006348 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 690566006349 substrate binding site [chemical binding]; other site 690566006350 active site 690566006351 PEP synthetase regulatory protein; Provisional; Region: PRK05339 690566006352 Maf-like protein; Region: Maf; pfam02545 690566006353 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 690566006354 active site 690566006355 dimer interface [polypeptide binding]; other site 690566006356 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 690566006357 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 690566006358 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 690566006359 shikimate binding site; other site 690566006360 NAD(P) binding site [chemical binding]; other site 690566006361 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 690566006362 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 690566006363 CoA-binding site [chemical binding]; other site 690566006364 ATP-binding [chemical binding]; other site 690566006365 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 690566006366 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 690566006367 active site 690566006368 catalytic site [active] 690566006369 substrate binding site [chemical binding]; other site 690566006370 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 690566006371 30S subunit binding site; other site 690566006372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 690566006373 active site 690566006374 phosphorylation site [posttranslational modification] 690566006375 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 690566006376 CoenzymeA binding site [chemical binding]; other site 690566006377 subunit interaction site [polypeptide binding]; other site 690566006378 PHB binding site; other site 690566006379 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 690566006380 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 690566006381 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 690566006382 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 690566006383 hypothetical protein; Validated; Region: PRK01415 690566006384 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 690566006385 active site residue [active] 690566006386 metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123 690566006387 active site 690566006388 metal binding site [ion binding]; metal-binding site 690566006389 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566006390 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566006391 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566006392 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 690566006393 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 690566006394 catalytic residue [active] 690566006395 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 690566006396 thiamine phosphate binding site [chemical binding]; other site 690566006397 active site 690566006398 pyrophosphate binding site [ion binding]; other site 690566006399 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 690566006400 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 690566006401 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 690566006402 HIGH motif; other site 690566006403 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 690566006404 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 690566006405 active site 690566006406 KMSKS motif; other site 690566006407 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 690566006408 tRNA binding surface [nucleotide binding]; other site 690566006409 Lipopolysaccharide-assembly; Region: LptE; pfam04390 690566006410 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 690566006411 methionine sulfoxide reductase B; Provisional; Region: PRK00222 690566006412 SelR domain; Region: SelR; pfam01641 690566006413 Transglycosylase; Region: Transgly; pfam00912 690566006414 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 690566006415 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 690566006416 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 690566006417 catalytic motif [active] 690566006418 Catalytic residue [active] 690566006419 Aspartyl protease; Region: Asp_protease_2; pfam13650 690566006420 inhibitor binding site; inhibition site 690566006421 catalytic motif [active] 690566006422 Catalytic residue [active] 690566006423 Active site flap [active] 690566006424 transcription termination factor Rho; Provisional; Region: rho; PRK09376 690566006425 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 690566006426 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 690566006427 RNA binding site [nucleotide binding]; other site 690566006428 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 690566006429 multimer interface [polypeptide binding]; other site 690566006430 Walker A motif; other site 690566006431 ATP binding site [chemical binding]; other site 690566006432 Walker B motif; other site 690566006433 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 690566006434 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 690566006435 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 690566006436 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 690566006437 NADP binding site [chemical binding]; other site 690566006438 dimer interface [polypeptide binding]; other site 690566006439 Dienelactone hydrolase family; Region: DLH; pfam01738 690566006440 Predicted ATPase [General function prediction only]; Region: COG2603 690566006441 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 690566006442 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 690566006443 trmE is a tRNA modification GTPase; Region: trmE; cd04164 690566006444 G1 box; other site 690566006445 GTP/Mg2+ binding site [chemical binding]; other site 690566006446 Switch I region; other site 690566006447 G2 box; other site 690566006448 Switch II region; other site 690566006449 G3 box; other site 690566006450 G5 box; other site 690566006451 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 690566006452 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 690566006453 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 690566006454 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 690566006455 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 690566006456 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 690566006457 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 690566006458 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566006459 P-loop; other site 690566006460 Magnesium ion binding site [ion binding]; other site 690566006461 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566006462 Magnesium ion binding site [ion binding]; other site 690566006463 ParB-like nuclease domain; Region: ParB; smart00470 690566006464 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566006465 aminopeptidase N; Provisional; Region: pepN; PRK14015 690566006466 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 690566006467 active site 690566006468 Zn binding site [ion binding]; other site 690566006469 Protein of unknown function (DUF330); Region: DUF330; cl01135 690566006470 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 690566006471 mce related protein; Region: MCE; pfam02470 690566006472 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 690566006473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566006474 Walker A/P-loop; other site 690566006475 ATP binding site [chemical binding]; other site 690566006476 Q-loop/lid; other site 690566006477 ABC transporter signature motif; other site 690566006478 Walker B; other site 690566006479 D-loop; other site 690566006480 H-loop/switch region; other site 690566006481 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 690566006482 anti sigma factor interaction site; other site 690566006483 regulatory phosphorylation site [posttranslational modification]; other site 690566006484 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 690566006485 Permease; Region: Permease; pfam02405 690566006486 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 690566006487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566006488 motif II; other site 690566006489 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 690566006490 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 690566006491 putative ligand binding site [chemical binding]; other site 690566006492 NAD binding site [chemical binding]; other site 690566006493 catalytic site [active] 690566006494 methionine gamma-lyase; Validated; Region: PRK07049 690566006495 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 690566006496 homodimer interface [polypeptide binding]; other site 690566006497 substrate-cofactor binding pocket; other site 690566006498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566006499 catalytic residue [active] 690566006500 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 690566006501 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566006502 ATP binding site [chemical binding]; other site 690566006503 putative Mg++ binding site [ion binding]; other site 690566006504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566006505 nucleotide binding region [chemical binding]; other site 690566006506 ATP-binding site [chemical binding]; other site 690566006507 DEAD/H associated; Region: DEAD_assoc; pfam08494 690566006508 Predicted membrane protein [Function unknown]; Region: COG3650 690566006509 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 690566006510 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 690566006511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566006512 Mg2+ binding site [ion binding]; other site 690566006513 G-X-G motif; other site 690566006514 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 690566006515 anchoring element; other site 690566006516 dimer interface [polypeptide binding]; other site 690566006517 ATP binding site [chemical binding]; other site 690566006518 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 690566006519 active site 690566006520 putative metal-binding site [ion binding]; other site 690566006521 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 690566006522 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 690566006523 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 690566006524 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 690566006525 hexamer interface [polypeptide binding]; other site 690566006526 metal binding site [ion binding]; metal-binding site 690566006527 substrate binding site [chemical binding]; other site 690566006528 16S rRNA methyltransferase B; Provisional; Region: PRK10901 690566006529 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 690566006530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566006531 S-adenosylmethionine binding site [chemical binding]; other site 690566006532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 690566006533 Protein of unknown function, DUF482; Region: DUF482; pfam04339 690566006534 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 690566006535 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 690566006536 active site 690566006537 catalytic site [active] 690566006538 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 690566006539 homotrimer interaction site [polypeptide binding]; other site 690566006540 putative active site [active] 690566006541 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 690566006542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566006543 Response regulator receiver domain; Region: Response_reg; pfam00072 690566006544 active site 690566006545 phosphorylation site [posttranslational modification] 690566006546 intermolecular recognition site; other site 690566006547 dimerization interface [polypeptide binding]; other site 690566006548 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 690566006549 dimer interface [polypeptide binding]; other site 690566006550 substrate binding site [chemical binding]; other site 690566006551 metal binding sites [ion binding]; metal-binding site 690566006552 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 690566006553 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 690566006554 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 690566006555 protein binding site [polypeptide binding]; other site 690566006556 histidyl-tRNA synthetase; Region: hisS; TIGR00442 690566006557 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 690566006558 dimer interface [polypeptide binding]; other site 690566006559 motif 1; other site 690566006560 active site 690566006561 motif 2; other site 690566006562 motif 3; other site 690566006563 peptide chain release factor 1; Validated; Region: prfA; PRK00591 690566006564 This domain is found in peptide chain release factors; Region: PCRF; smart00937 690566006565 RF-1 domain; Region: RF-1; pfam00472 690566006566 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 690566006567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566006568 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 690566006569 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 690566006570 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 690566006571 FOG: CBS domain [General function prediction only]; Region: COG0517 690566006572 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 690566006573 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 690566006574 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 690566006575 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 690566006576 amino acid transporter; Region: 2A0306; TIGR00909 690566006577 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 690566006578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566006579 putative substrate translocation pore; other site 690566006580 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 690566006581 Sel1-like repeats; Region: SEL1; smart00671 690566006582 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566006583 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 690566006584 FMN binding site [chemical binding]; other site 690566006585 active site 690566006586 substrate binding site [chemical binding]; other site 690566006587 catalytic residue [active] 690566006588 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 690566006589 COQ9; Region: COQ9; pfam08511 690566006590 FeoA domain; Region: FeoA; pfam04023 690566006591 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 690566006592 ferrous iron transporter FeoB; Region: feoB; TIGR00437 690566006593 G1 box; other site 690566006594 GTP/Mg2+ binding site [chemical binding]; other site 690566006595 Switch I region; other site 690566006596 G2 box; other site 690566006597 G3 box; other site 690566006598 Switch II region; other site 690566006599 G4 box; other site 690566006600 G5 box; other site 690566006601 Nucleoside recognition; Region: Gate; pfam07670 690566006602 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 690566006603 Nucleoside recognition; Region: Gate; pfam07670 690566006604 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 690566006605 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 690566006606 dimer interface [polypeptide binding]; other site 690566006607 ssDNA binding site [nucleotide binding]; other site 690566006608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 690566006609 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 690566006610 homotrimer interaction site [polypeptide binding]; other site 690566006611 putative active site [active] 690566006612 ArsC family; Region: ArsC; pfam03960 690566006613 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 690566006614 putative catalytic residues [active] 690566006615 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 690566006616 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 690566006617 active site 690566006618 catalytic site [active] 690566006619 Rrf2 family protein; Region: rrf2_super; TIGR00738 690566006620 Transcriptional regulator; Region: Rrf2; pfam02082 690566006621 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 690566006622 MAPEG family; Region: MAPEG; cl09190 690566006623 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 690566006624 putative phosphate acyltransferase; Provisional; Region: PRK05331 690566006625 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 690566006626 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 690566006627 dimer interface [polypeptide binding]; other site 690566006628 active site 690566006629 CoA binding pocket [chemical binding]; other site 690566006630 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 690566006631 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 690566006632 purine monophosphate binding site [chemical binding]; other site 690566006633 dimer interface [polypeptide binding]; other site 690566006634 putative catalytic residues [active] 690566006635 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 690566006636 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 690566006637 hypothetical protein; Provisional; Region: PRK07208 690566006638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566006639 GtrA-like protein; Region: GtrA; pfam04138 690566006640 methionine sulfoxide reductase B; Provisional; Region: PRK00222 690566006641 SelR domain; Region: SelR; pfam01641 690566006642 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 690566006643 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 690566006644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566006645 Walker A/P-loop; other site 690566006646 ATP binding site [chemical binding]; other site 690566006647 Q-loop/lid; other site 690566006648 ABC transporter signature motif; other site 690566006649 Walker B; other site 690566006650 D-loop; other site 690566006651 H-loop/switch region; other site 690566006652 epoxyqueuosine reductase; Region: TIGR00276 690566006653 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 690566006654 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 690566006655 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 690566006656 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 690566006657 substrate binding site [chemical binding]; other site 690566006658 ATP binding site [chemical binding]; other site 690566006659 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 690566006660 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 690566006661 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 690566006662 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 690566006663 UGMP family protein; Validated; Region: PRK09604 690566006664 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 690566006665 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 690566006666 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 690566006667 domain interfaces; other site 690566006668 active site 690566006669 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 690566006670 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 690566006671 active site 690566006672 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 690566006673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566006674 PGAP1-like protein; Region: PGAP1; pfam07819 690566006675 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 690566006676 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 690566006677 active site 690566006678 HIGH motif; other site 690566006679 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 690566006680 active site 690566006681 KMSKS motif; other site 690566006682 NAD synthetase; Provisional; Region: PRK13981 690566006683 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 690566006684 multimer interface [polypeptide binding]; other site 690566006685 active site 690566006686 catalytic triad [active] 690566006687 protein interface 1 [polypeptide binding]; other site 690566006688 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 690566006689 homodimer interface [polypeptide binding]; other site 690566006690 NAD binding pocket [chemical binding]; other site 690566006691 ATP binding pocket [chemical binding]; other site 690566006692 Mg binding site [ion binding]; other site 690566006693 active-site loop [active] 690566006694 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 690566006695 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 690566006696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566006697 active site 690566006698 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 690566006699 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566006700 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 690566006701 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 690566006702 active site 690566006703 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 690566006704 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 690566006705 23S rRNA binding site [nucleotide binding]; other site 690566006706 L21 binding site [polypeptide binding]; other site 690566006707 L13 binding site [polypeptide binding]; other site 690566006708 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 690566006709 GIY-YIG motif/motif A; other site 690566006710 putative active site [active] 690566006711 putative metal binding site [ion binding]; other site 690566006712 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 690566006713 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 690566006714 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 690566006715 dimer interface [polypeptide binding]; other site 690566006716 motif 1; other site 690566006717 active site 690566006718 motif 2; other site 690566006719 motif 3; other site 690566006720 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 690566006721 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 690566006722 putative tRNA-binding site [nucleotide binding]; other site 690566006723 B3/4 domain; Region: B3_4; pfam03483 690566006724 tRNA synthetase B5 domain; Region: B5; smart00874 690566006725 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 690566006726 dimer interface [polypeptide binding]; other site 690566006727 motif 1; other site 690566006728 motif 3; other site 690566006729 motif 2; other site 690566006730 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 690566006731 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 690566006732 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 690566006733 active site 690566006734 catalytic residues [active] 690566006735 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 690566006736 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 690566006737 G1 box; other site 690566006738 putative GEF interaction site [polypeptide binding]; other site 690566006739 GTP/Mg2+ binding site [chemical binding]; other site 690566006740 Switch I region; other site 690566006741 G2 box; other site 690566006742 G3 box; other site 690566006743 Switch II region; other site 690566006744 G4 box; other site 690566006745 G5 box; other site 690566006746 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 690566006747 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566006748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566006749 S-adenosylmethionine binding site [chemical binding]; other site 690566006750 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 690566006751 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 690566006752 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 690566006753 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 690566006754 putative ligand binding site [chemical binding]; other site 690566006755 NAD binding site [chemical binding]; other site 690566006756 catalytic site [active] 690566006757 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 690566006758 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566006759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566006760 homodimer interface [polypeptide binding]; other site 690566006761 catalytic residue [active] 690566006762 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 690566006763 prephenate dehydrogenase; Validated; Region: PRK08507 690566006764 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 690566006765 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 690566006766 putative acyl-acceptor binding pocket; other site 690566006767 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 690566006768 putative active site [active] 690566006769 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 690566006770 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 690566006771 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 690566006772 Walker A/P-loop; other site 690566006773 ATP binding site [chemical binding]; other site 690566006774 Q-loop/lid; other site 690566006775 ABC transporter signature motif; other site 690566006776 Walker B; other site 690566006777 D-loop; other site 690566006778 H-loop/switch region; other site 690566006779 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 690566006780 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 690566006781 Pirin-related protein [General function prediction only]; Region: COG1741 690566006782 Pirin; Region: Pirin; pfam02678 690566006783 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 690566006784 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 690566006785 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 690566006786 HSP70 interaction site [polypeptide binding]; other site 690566006787 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 690566006788 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 690566006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 690566006790 OsmC-like protein; Region: OsmC; pfam02566 690566006791 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 690566006792 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 690566006793 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 690566006794 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 690566006795 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 690566006796 metal ion-dependent adhesion site (MIDAS); other site 690566006797 transcription elongation factor regulatory protein; Validated; Region: PRK06342 690566006798 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 690566006799 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 690566006800 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 690566006801 dimerization interface [polypeptide binding]; other site 690566006802 DPS ferroxidase diiron center [ion binding]; other site 690566006803 ion pore; other site 690566006804 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 690566006805 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 690566006806 homopentamer interface [polypeptide binding]; other site 690566006807 active site 690566006808 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 690566006809 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 690566006810 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 690566006811 dimerization interface [polypeptide binding]; other site 690566006812 active site 690566006813 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 690566006814 Lumazine binding domain; Region: Lum_binding; pfam00677 690566006815 Lumazine binding domain; Region: Lum_binding; pfam00677 690566006816 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 690566006817 catalytic motif [active] 690566006818 Zn binding site [ion binding]; other site 690566006819 RibD C-terminal domain; Region: RibD_C; cl17279 690566006820 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 690566006821 Protein of unknown function (DUF445); Region: DUF445; pfam04286 690566006822 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 690566006823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566006824 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566006825 Predicted membrane protein [Function unknown]; Region: COG2261 690566006826 Predicted membrane protein [Function unknown]; Region: COG2261 690566006827 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 690566006828 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 690566006829 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 690566006830 Ligand Binding Site [chemical binding]; other site 690566006831 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 690566006832 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 690566006833 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 690566006834 histidinol dehydrogenase; Region: hisD; TIGR00069 690566006835 NAD binding site [chemical binding]; other site 690566006836 dimerization interface [polypeptide binding]; other site 690566006837 product binding site; other site 690566006838 substrate binding site [chemical binding]; other site 690566006839 zinc binding site [ion binding]; other site 690566006840 catalytic residues [active] 690566006841 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 690566006842 thiamine-monophosphate kinase; Region: thiL; TIGR01379 690566006843 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 690566006844 ATP binding site [chemical binding]; other site 690566006845 dimerization interface [polypeptide binding]; other site 690566006846 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 690566006847 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 690566006848 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 690566006849 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 690566006850 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 690566006851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566006852 catalytic residue [active] 690566006853 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 690566006854 AAA domain; Region: AAA_26; pfam13500 690566006855 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 690566006856 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 690566006857 active site 690566006858 Zn binding site [ion binding]; other site 690566006859 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 690566006860 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 690566006861 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 690566006862 inhibitor-cofactor binding pocket; inhibition site 690566006863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566006864 catalytic residue [active] 690566006865 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 690566006866 rRNA binding site [nucleotide binding]; other site 690566006867 predicted 30S ribosome binding site; other site 690566006868 Maf-like protein; Region: Maf; pfam02545 690566006869 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 690566006870 active site 690566006871 dimer interface [polypeptide binding]; other site 690566006872 Domain of unknown function (DUF329); Region: DUF329; cl01144 690566006873 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 690566006874 Phage integrase family; Region: Phage_integrase; pfam00589 690566006875 active site 690566006876 DNA binding site [nucleotide binding] 690566006877 Int/Topo IB signature motif; other site 690566006878 Helix-turn-helix domain; Region: HTH_17; pfam12728 690566006879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 690566006880 HTH-like domain; Region: HTH_21; pfam13276 690566006881 Integrase core domain; Region: rve; pfam00665 690566006882 Integrase core domain; Region: rve_3; pfam13683 690566006883 Transposase; Region: HTH_Tnp_1; pfam01527 690566006884 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 690566006885 multiple promoter invertase; Provisional; Region: mpi; PRK13413 690566006886 catalytic residues [active] 690566006887 catalytic nucleophile [active] 690566006888 Presynaptic Site I dimer interface [polypeptide binding]; other site 690566006889 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 690566006890 Synaptic Flat tetramer interface [polypeptide binding]; other site 690566006891 Synaptic Site I dimer interface [polypeptide binding]; other site 690566006892 DNA binding site [nucleotide binding] 690566006893 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 690566006894 DNA-binding interface [nucleotide binding]; DNA binding site 690566006895 Restriction alleviation protein Lar; Region: Lar_restr_allev; cl08047 690566006896 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 690566006897 mismatch recognition site; other site 690566006898 additional DNA contacts [nucleotide binding]; other site 690566006899 active site 690566006900 zinc binding site [ion binding]; other site 690566006901 DNA intercalation site [nucleotide binding]; other site 690566006902 Cfr10I/Bse634I restriction endonuclease; Region: Bse634I; pfam07832 690566006903 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 690566006904 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 690566006905 cofactor binding site; other site 690566006906 DNA binding site [nucleotide binding] 690566006907 substrate interaction site [chemical binding]; other site 690566006908 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 690566006909 ski2-like helicase; Provisional; Region: PRK02362 690566006910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 690566006911 ATP binding site [chemical binding]; other site 690566006912 putative Mg++ binding site [ion binding]; other site 690566006913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566006914 nucleotide binding region [chemical binding]; other site 690566006915 ATP-binding site [chemical binding]; other site 690566006916 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 690566006917 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 690566006918 polymerase nucleotide-binding site; other site 690566006919 DNA-binding residues [nucleotide binding]; DNA binding site 690566006920 nucleotide binding site [chemical binding]; other site 690566006921 primase nucleotide-binding site [nucleotide binding]; other site 690566006922 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 690566006923 AAA domain; Region: AAA_25; pfam13481 690566006924 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566006925 Walker A motif; other site 690566006926 ATP binding site [chemical binding]; other site 690566006927 Walker B motif; other site 690566006928 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 690566006929 Protein of unknown function DUF262; Region: DUF262; pfam03235 690566006930 Uncharacterized conserved protein [Function unknown]; Region: COG1479 690566006931 Protein of unknown function DUF262; Region: DUF262; pfam03235 690566006932 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 690566006933 Pirin-related protein [General function prediction only]; Region: COG1741 690566006934 Pirin; Region: Pirin; pfam02678 690566006935 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 690566006936 Low molecular weight phosphatase family; Region: LMWPc; cd00115 690566006937 active site 690566006938 HerA helicase [Replication, recombination, and repair]; Region: COG0433 690566006939 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 690566006940 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 690566006941 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 690566006942 active site 690566006943 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 690566006944 MgtE intracellular N domain; Region: MgtE_N; smart00924 690566006945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 690566006946 Divalent cation transporter; Region: MgtE; pfam01769 690566006947 Protein of unknown function (DUF1489); Region: DUF1489; cl11570 690566006948 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 690566006949 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 690566006950 Fe-S cluster binding site [ion binding]; other site 690566006951 active site 690566006952 Hemerythrin-like domain; Region: Hr-like; cd12108 690566006953 Fe binding site [ion binding]; other site 690566006954 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 690566006955 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566006956 FeS/SAM binding site; other site 690566006957 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 690566006958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 690566006959 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 690566006960 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 690566006961 Cu(I) binding site [ion binding]; other site 690566006962 hypothetical protein; Provisional; Region: PRK05170 690566006963 Protein of unknown function DUF45; Region: DUF45; pfam01863 690566006964 aldolase II superfamily protein; Provisional; Region: PRK07044 690566006965 intersubunit interface [polypeptide binding]; other site 690566006966 active site 690566006967 Zn2+ binding site [ion binding]; other site 690566006968 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 690566006969 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 690566006970 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 690566006971 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 690566006972 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 690566006973 Domain of unknown function DUF20; Region: UPF0118; pfam01594 690566006974 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 690566006975 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 690566006976 Catalytic site [active] 690566006977 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 690566006978 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 690566006979 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 690566006980 active site 690566006981 hydrophilic channel; other site 690566006982 dimerization interface [polypeptide binding]; other site 690566006983 catalytic residues [active] 690566006984 active site lid [active] 690566006985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566006986 active site 690566006987 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 690566006988 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 690566006989 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 690566006990 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 690566006991 Subunit I/III interface [polypeptide binding]; other site 690566006992 D-pathway; other site 690566006993 Subunit I/VIIc interface [polypeptide binding]; other site 690566006994 Subunit I/IV interface [polypeptide binding]; other site 690566006995 Subunit I/II interface [polypeptide binding]; other site 690566006996 Low-spin heme (heme a) binding site [chemical binding]; other site 690566006997 Subunit I/VIIa interface [polypeptide binding]; other site 690566006998 Subunit I/VIa interface [polypeptide binding]; other site 690566006999 Dimer interface; other site 690566007000 Putative water exit pathway; other site 690566007001 Binuclear center (heme a3/CuB) [ion binding]; other site 690566007002 K-pathway; other site 690566007003 Subunit I/Vb interface [polypeptide binding]; other site 690566007004 Putative proton exit pathway; other site 690566007005 Subunit I/VIb interface; other site 690566007006 Subunit I/VIc interface [polypeptide binding]; other site 690566007007 Electron transfer pathway; other site 690566007008 Subunit I/VIIIb interface [polypeptide binding]; other site 690566007009 Subunit I/VIIb interface [polypeptide binding]; other site 690566007010 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 690566007011 UbiA prenyltransferase family; Region: UbiA; pfam01040 690566007012 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 690566007013 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 690566007014 Subunit III/VIIa interface [polypeptide binding]; other site 690566007015 Phospholipid binding site [chemical binding]; other site 690566007016 Subunit I/III interface [polypeptide binding]; other site 690566007017 Subunit III/VIb interface [polypeptide binding]; other site 690566007018 Subunit III/VIa interface; other site 690566007019 Subunit III/Vb interface [polypeptide binding]; other site 690566007020 Protein of unknown function (DUF983); Region: DUF983; cl02211 690566007021 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cl01321 690566007022 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 690566007023 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 690566007024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566007025 catalytic residue [active] 690566007026 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 690566007027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566007028 S-adenosylmethionine binding site [chemical binding]; other site 690566007029 beta-carotene hydroxylase; Region: PLN02601 690566007030 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 690566007031 Mechanosensitive ion channel; Region: MS_channel; pfam00924 690566007032 cystathionine beta-lyase; Provisional; Region: PRK09028 690566007033 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 690566007034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 690566007035 catalytic residue [active] 690566007036 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 690566007037 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 690566007038 active site residue [active] 690566007039 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 690566007040 active site residue [active] 690566007041 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 690566007042 Peptidase family M1; Region: Peptidase_M1; pfam01433 690566007043 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 690566007044 Zn binding site [ion binding]; other site 690566007045 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 690566007046 Predicted membrane protein [Function unknown]; Region: COG1297 690566007047 putative oligopeptide transporter, OPT family; Region: TIGR00733 690566007048 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 690566007049 active site 690566007050 catalytic triad [active] 690566007051 oxyanion hole [active] 690566007052 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 690566007053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566007054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007055 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 690566007056 PLD-like domain; Region: PLDc_2; pfam13091 690566007057 putative active site [active] 690566007058 catalytic site [active] 690566007059 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 690566007060 PLD-like domain; Region: PLDc_2; pfam13091 690566007061 putative active site [active] 690566007062 catalytic site [active] 690566007063 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 690566007064 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 690566007065 Predicted integral membrane protein [Function unknown]; Region: COG0392 690566007066 Uncharacterized conserved protein [Function unknown]; Region: COG2898 690566007067 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 690566007068 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 690566007069 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 690566007070 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 690566007071 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 690566007072 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 690566007073 putative FMN binding site [chemical binding]; other site 690566007074 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 690566007075 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 690566007076 ring oligomerisation interface [polypeptide binding]; other site 690566007077 ATP/Mg binding site [chemical binding]; other site 690566007078 stacking interactions; other site 690566007079 hinge regions; other site 690566007080 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 690566007081 oligomerisation interface [polypeptide binding]; other site 690566007082 mobile loop; other site 690566007083 roof hairpin; other site 690566007084 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566007085 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566007086 putative S-transferase; Provisional; Region: PRK11752 690566007087 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 690566007088 C-terminal domain interface [polypeptide binding]; other site 690566007089 GSH binding site (G-site) [chemical binding]; other site 690566007090 dimer interface [polypeptide binding]; other site 690566007091 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 690566007092 dimer interface [polypeptide binding]; other site 690566007093 N-terminal domain interface [polypeptide binding]; other site 690566007094 active site 690566007095 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 690566007096 active site 690566007097 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 690566007098 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 690566007099 NodB motif; other site 690566007100 putative active site [active] 690566007101 putative catalytic site [active] 690566007102 putative Zn binding site [ion binding]; other site 690566007103 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 690566007104 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 690566007105 DXD motif; other site 690566007106 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 690566007107 protein binding site [polypeptide binding]; other site 690566007108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566007109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007110 active site 690566007111 phosphorylation site [posttranslational modification] 690566007112 intermolecular recognition site; other site 690566007113 dimerization interface [polypeptide binding]; other site 690566007114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566007115 DNA binding site [nucleotide binding] 690566007116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566007117 HAMP domain; Region: HAMP; pfam00672 690566007118 dimerization interface [polypeptide binding]; other site 690566007119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566007120 dimer interface [polypeptide binding]; other site 690566007121 phosphorylation site [posttranslational modification] 690566007122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566007123 ATP binding site [chemical binding]; other site 690566007124 Mg2+ binding site [ion binding]; other site 690566007125 G-X-G motif; other site 690566007126 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566007127 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566007128 DNA binding site [nucleotide binding] 690566007129 domain linker motif; other site 690566007130 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 690566007131 putative dimerization interface [polypeptide binding]; other site 690566007132 putative ligand binding site [chemical binding]; other site 690566007133 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 690566007134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566007135 putative substrate translocation pore; other site 690566007136 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566007137 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007138 N-terminal plug; other site 690566007139 ligand-binding site [chemical binding]; other site 690566007140 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 690566007141 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 690566007142 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 690566007143 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566007144 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007145 N-terminal plug; other site 690566007146 ligand-binding site [chemical binding]; other site 690566007147 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 690566007148 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 690566007149 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 690566007150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566007151 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 690566007152 Uncharacterized conserved protein [Function unknown]; Region: COG2128 690566007153 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 690566007154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566007155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566007156 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 690566007157 putative effector binding pocket; other site 690566007158 putative dimerization interface [polypeptide binding]; other site 690566007159 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 690566007160 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 690566007161 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 690566007162 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 690566007163 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 690566007164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566007165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007166 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 690566007167 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 690566007168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566007169 NAD(P) binding site [chemical binding]; other site 690566007170 active site 690566007171 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 690566007172 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 690566007173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566007174 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007175 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 690566007176 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 690566007177 conserved cys residue [active] 690566007178 TrbC/VIRB2 family; Region: TrbC; pfam04956 690566007179 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 690566007180 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 690566007181 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566007182 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566007183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007184 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566007185 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566007186 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566007187 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 690566007188 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 690566007189 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 690566007190 dimer interface [polypeptide binding]; other site 690566007191 active site 690566007192 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 690566007193 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 690566007194 active site 690566007195 dimer interface [polypeptide binding]; other site 690566007196 metal binding site [ion binding]; metal-binding site 690566007197 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 690566007198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007199 hypothetical protein; Provisional; Region: PRK06126 690566007200 hypothetical protein; Provisional; Region: PRK07236 690566007201 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566007202 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 690566007203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 690566007204 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566007205 active site 690566007206 metal binding site [ion binding]; metal-binding site 690566007207 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 690566007208 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566007209 Prostaglandin dehydrogenases; Region: PGDH; cd05288 690566007210 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 690566007211 NAD(P) binding site [chemical binding]; other site 690566007212 substrate binding site [chemical binding]; other site 690566007213 dimer interface [polypeptide binding]; other site 690566007214 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 690566007215 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566007216 classical (c) SDRs; Region: SDR_c; cd05233 690566007217 NAD(P) binding site [chemical binding]; other site 690566007218 active site 690566007219 Protein of unknown function (DUF2920); Region: DUF2920; pfam11144 690566007220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566007221 AMP-binding domain protein; Validated; Region: PRK08315 690566007222 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566007223 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566007224 acyl-activating enzyme (AAE) consensus motif; other site 690566007225 putative AMP binding site [chemical binding]; other site 690566007226 putative active site [active] 690566007227 putative CoA binding site [chemical binding]; other site 690566007228 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566007229 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007230 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 690566007231 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 690566007232 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566007233 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566007234 active site 690566007235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566007236 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566007237 NAD(P) binding site [chemical binding]; other site 690566007238 active site 690566007239 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566007240 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007241 N-terminal plug; other site 690566007242 ligand-binding site [chemical binding]; other site 690566007243 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566007244 Cytochrome P450; Region: p450; cl12078 690566007245 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 690566007246 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 690566007247 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566007248 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007249 N-terminal plug; other site 690566007250 ligand-binding site [chemical binding]; other site 690566007251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566007252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566007253 dimer interface [polypeptide binding]; other site 690566007254 phosphorylation site [posttranslational modification] 690566007255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566007256 ATP binding site [chemical binding]; other site 690566007257 Mg2+ binding site [ion binding]; other site 690566007258 G-X-G motif; other site 690566007259 Response regulator receiver domain; Region: Response_reg; pfam00072 690566007260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007261 active site 690566007262 phosphorylation site [posttranslational modification] 690566007263 intermolecular recognition site; other site 690566007264 dimerization interface [polypeptide binding]; other site 690566007265 Response regulator receiver domain; Region: Response_reg; pfam00072 690566007266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007267 active site 690566007268 phosphorylation site [posttranslational modification] 690566007269 intermolecular recognition site; other site 690566007270 dimerization interface [polypeptide binding]; other site 690566007271 PAS domain S-box; Region: sensory_box; TIGR00229 690566007272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566007273 putative active site [active] 690566007274 heme pocket [chemical binding]; other site 690566007275 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566007276 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566007277 metal binding site [ion binding]; metal-binding site 690566007278 active site 690566007279 I-site; other site 690566007280 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566007281 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 690566007282 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 690566007283 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 690566007284 hexamer interface [polypeptide binding]; other site 690566007285 ligand binding site [chemical binding]; other site 690566007286 putative active site [active] 690566007287 NAD(P) binding site [chemical binding]; other site 690566007288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566007289 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 690566007290 putative NAD(P) binding site [chemical binding]; other site 690566007291 active site 690566007292 putative substrate binding site [chemical binding]; other site 690566007293 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 690566007294 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 690566007295 putative active site [active] 690566007296 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 690566007297 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 690566007298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566007299 active site 690566007300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 690566007301 OstA-like protein; Region: OstA; pfam03968 690566007302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 690566007303 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 690566007304 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 690566007305 catalytic site [active] 690566007306 putative active site [active] 690566007307 putative substrate binding site [chemical binding]; other site 690566007308 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 690566007309 DNA-binding site [nucleotide binding]; DNA binding site 690566007310 RNA-binding motif; other site 690566007311 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 690566007312 DNA-binding site [nucleotide binding]; DNA binding site 690566007313 RNA-binding motif; other site 690566007314 MT-A70; Region: MT-A70; cl01947 690566007315 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 690566007316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 690566007317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566007318 non-specific DNA binding site [nucleotide binding]; other site 690566007319 salt bridge; other site 690566007320 sequence-specific DNA binding site [nucleotide binding]; other site 690566007321 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 690566007322 Domain of unknown function (DUF955); Region: DUF955; pfam06114 690566007323 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 690566007324 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 690566007325 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 690566007326 nudix motif; other site 690566007327 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 690566007328 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 690566007329 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007330 N-terminal plug; other site 690566007331 ligand-binding site [chemical binding]; other site 690566007332 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566007333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566007334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 690566007335 dimerization interface [polypeptide binding]; other site 690566007336 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 690566007337 putative active site [active] 690566007338 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 690566007339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 690566007340 active site 690566007341 catalytic residues [active] 690566007342 DNA binding site [nucleotide binding] 690566007343 Int/Topo IB signature motif; other site 690566007344 Caspase domain; Region: Peptidase_C14; pfam00656 690566007345 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 690566007346 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566007347 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 690566007348 Beta-lactamase; Region: Beta-lactamase; pfam00144 690566007349 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566007350 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566007351 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566007352 DNA binding site [nucleotide binding] 690566007353 domain linker motif; other site 690566007354 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 690566007355 putative dimerization interface [polypeptide binding]; other site 690566007356 putative ligand binding site [chemical binding]; other site 690566007357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 690566007358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 690566007359 nucleotide binding site [chemical binding]; other site 690566007360 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 690566007361 active site 690566007362 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566007363 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 690566007364 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566007365 AMP-binding domain protein; Validated; Region: PRK08315 690566007366 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566007367 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566007368 acyl-activating enzyme (AAE) consensus motif; other site 690566007369 putative AMP binding site [chemical binding]; other site 690566007370 putative active site [active] 690566007371 putative CoA binding site [chemical binding]; other site 690566007372 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 690566007373 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 690566007374 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566007375 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566007376 Helix-turn-helix domain; Region: HTH_17; cl17695 690566007377 integrase; Provisional; Region: PRK09692 690566007378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566007379 active site 690566007380 DNA binding site [nucleotide binding] 690566007381 Int/Topo IB signature motif; other site 690566007382 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 690566007383 argininosuccinate synthase; Provisional; Region: PRK13820 690566007384 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 690566007385 ANP binding site [chemical binding]; other site 690566007386 Substrate Binding Site II [chemical binding]; other site 690566007387 Substrate Binding Site I [chemical binding]; other site 690566007388 EF-hand domain pair; Region: EF_hand_5; pfam13499 690566007389 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 690566007390 Ca2+ binding site [ion binding]; other site 690566007391 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 690566007392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 690566007393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007394 active site 690566007395 phosphorylation site [posttranslational modification] 690566007396 intermolecular recognition site; other site 690566007397 dimerization interface [polypeptide binding]; other site 690566007398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566007399 DNA binding site [nucleotide binding] 690566007400 HAMP domain; Region: HAMP; pfam00672 690566007401 dimerization interface [polypeptide binding]; other site 690566007402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566007403 dimer interface [polypeptide binding]; other site 690566007404 phosphorylation site [posttranslational modification] 690566007405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566007406 ATP binding site [chemical binding]; other site 690566007407 Mg2+ binding site [ion binding]; other site 690566007408 G-X-G motif; other site 690566007409 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 690566007410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566007411 binding surface 690566007412 TPR motif; other site 690566007413 TPR repeat; Region: TPR_11; pfam13414 690566007414 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 690566007415 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566007416 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566007417 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 690566007418 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 690566007419 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 690566007420 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 690566007421 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 690566007422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 690566007423 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 690566007424 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 690566007425 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 690566007426 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 690566007427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 690566007428 Protein of unknown function, DUF488; Region: DUF488; pfam04343 690566007429 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 690566007430 ligand binding site [chemical binding]; other site 690566007431 active site 690566007432 UGI interface [polypeptide binding]; other site 690566007433 catalytic site [active] 690566007434 beta-lactamase TEM; Provisional; Region: PRK15442 690566007435 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 690566007436 Protein of unknown function (DUF962); Region: DUF962; pfam06127 690566007437 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 690566007438 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 690566007439 Cupin-like domain; Region: Cupin_8; pfam13621 690566007440 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 690566007441 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 690566007442 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 690566007443 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566007444 ligand binding site [chemical binding]; other site 690566007445 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 690566007446 flagellar motor protein MotA; Validated; Region: PRK09110 690566007447 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 690566007448 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 690566007449 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 690566007450 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 690566007451 Rod binding protein; Region: Rod-binding; cl01626 690566007452 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 690566007453 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 690566007454 Flagellar L-ring protein; Region: FlgH; pfam02107 690566007455 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 690566007456 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 690566007457 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 690566007458 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 690566007459 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 690566007460 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 690566007461 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 690566007462 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 690566007463 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 690566007464 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 690566007465 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 690566007466 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 690566007467 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 690566007468 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 690566007469 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 690566007470 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 690566007471 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 690566007472 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 690566007473 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 690566007474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566007475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566007476 catalytic residue [active] 690566007477 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 690566007478 FHIPEP family; Region: FHIPEP; pfam00771 690566007479 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 690566007480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566007481 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 690566007482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566007483 DNA binding residues [nucleotide binding] 690566007484 glucosyltransferase MdoH; Provisional; Region: PRK05454 690566007485 active site 690566007486 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 690566007487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566007488 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 690566007489 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 690566007490 flagellin; Provisional; Region: PRK12802 690566007491 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 690566007492 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 690566007493 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 690566007494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566007495 Walker A motif; other site 690566007496 ATP binding site [chemical binding]; other site 690566007497 Walker B motif; other site 690566007498 arginine finger; other site 690566007499 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 690566007500 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 690566007501 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 690566007502 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 690566007503 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 690566007504 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 690566007505 MgtE intracellular N domain; Region: MgtE_N; smart00924 690566007506 FliG C-terminal domain; Region: FliG_C; pfam01706 690566007507 Flagellar assembly protein FliH; Region: FliH; pfam02108 690566007508 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 690566007509 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566007510 Walker A motif; other site 690566007511 ATP binding site [chemical binding]; other site 690566007512 Walker B motif; other site 690566007513 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 690566007514 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 690566007515 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 690566007516 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 690566007517 flagellar motor switch protein FliN; Region: fliN; TIGR02480 690566007518 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 690566007519 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 690566007520 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 690566007521 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 690566007522 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 690566007523 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 690566007524 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 690566007525 Flagellar protein FliS; Region: FliS; cl00654 690566007526 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 690566007527 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 690566007528 inhibitor-cofactor binding pocket; inhibition site 690566007529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566007530 catalytic residue [active] 690566007531 ornithine carbamoyltransferase; Provisional; Region: PRK00779 690566007532 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 690566007533 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 690566007534 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 690566007535 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 690566007536 dimerization interface [polypeptide binding]; other site 690566007537 domain crossover interface; other site 690566007538 redox-dependent activation switch; other site 690566007539 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 690566007540 Ligand Binding Site [chemical binding]; other site 690566007541 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 690566007542 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 690566007543 lipoate-protein ligase B; Provisional; Region: PRK14341 690566007544 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 690566007545 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 690566007546 Coenzyme A binding pocket [chemical binding]; other site 690566007547 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 690566007548 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 690566007549 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 690566007550 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 690566007551 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 690566007552 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 690566007553 [2Fe-2S] cluster binding site [ion binding]; other site 690566007554 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 690566007555 cytochrome b; Provisional; Region: CYTB; MTH00156 690566007556 interchain domain interface [polypeptide binding]; other site 690566007557 intrachain domain interface; other site 690566007558 heme bH binding site [chemical binding]; other site 690566007559 Qi binding site; other site 690566007560 heme bL binding site [chemical binding]; other site 690566007561 Qo binding site; other site 690566007562 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 690566007563 interchain domain interface [polypeptide binding]; other site 690566007564 intrachain domain interface; other site 690566007565 Qi binding site; other site 690566007566 Qo binding site; other site 690566007567 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 690566007568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566007569 active site 690566007570 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative; Region: MTA/SAH-nuc-hyp; TIGR01705 690566007571 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 690566007572 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 690566007573 Autotransporter beta-domain; Region: Autotransporter; smart00869 690566007574 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566007575 active site 690566007576 DNA binding site [nucleotide binding] 690566007577 Int/Topo IB signature motif; other site 690566007578 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 690566007579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566007580 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 690566007581 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 690566007582 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566007583 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 690566007584 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 690566007585 Walker A/P-loop; other site 690566007586 ATP binding site [chemical binding]; other site 690566007587 Q-loop/lid; other site 690566007588 ABC transporter signature motif; other site 690566007589 Walker B; other site 690566007590 D-loop; other site 690566007591 H-loop/switch region; other site 690566007592 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 690566007593 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 690566007594 substrate binding site; other site 690566007595 tetramer interface; other site 690566007596 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 690566007597 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 690566007598 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 690566007599 NADP binding site [chemical binding]; other site 690566007600 active site 690566007601 putative substrate binding site [chemical binding]; other site 690566007602 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 690566007603 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 690566007604 NAD binding site [chemical binding]; other site 690566007605 substrate binding site [chemical binding]; other site 690566007606 homodimer interface [polypeptide binding]; other site 690566007607 active site 690566007608 TPR repeat; Region: TPR_11; pfam13414 690566007609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566007610 TPR motif; other site 690566007611 binding surface 690566007612 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 690566007613 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 690566007614 Probable Catalytic site; other site 690566007615 metal-binding site 690566007616 Methyltransferase domain; Region: Methyltransf_24; pfam13578 690566007617 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 690566007618 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 690566007619 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 690566007620 Tetratricopeptide repeat; Region: TPR_16; pfam13432 690566007621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566007622 TPR motif; other site 690566007623 binding surface 690566007624 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 690566007625 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 690566007626 Probable Catalytic site; other site 690566007627 metal-binding site 690566007628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 690566007629 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 690566007630 Probable Catalytic site; other site 690566007631 metal-binding site 690566007632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566007633 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 690566007634 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 690566007635 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 690566007636 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 690566007637 GSCFA family; Region: GSCFA; pfam08885 690566007638 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 690566007639 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 690566007640 dimerization interface [polypeptide binding]; other site 690566007641 putative active cleft [active] 690566007642 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 690566007643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566007644 active site 690566007645 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 690566007646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566007647 active site 690566007648 motif I; other site 690566007649 motif II; other site 690566007650 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 690566007651 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566007652 Methyltransferase domain; Region: Methyltransf_11; pfam08241 690566007653 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566007654 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 690566007655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 690566007656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566007657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566007658 DNA binding residues [nucleotide binding] 690566007659 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 690566007660 FecR protein; Region: FecR; pfam04773 690566007661 Secretin and TonB N terminus short domain; Region: STN; smart00965 690566007662 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007663 N-terminal plug; other site 690566007664 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 690566007665 ligand-binding site [chemical binding]; other site 690566007666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 690566007667 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566007668 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 690566007669 Ligand Binding Site [chemical binding]; other site 690566007670 Molecular Tunnel; other site 690566007671 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 690566007672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566007673 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566007674 DNA-binding site [nucleotide binding]; DNA binding site 690566007675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566007676 non-specific DNA binding site [nucleotide binding]; other site 690566007677 salt bridge; other site 690566007678 sequence-specific DNA binding site [nucleotide binding]; other site 690566007679 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 690566007680 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 690566007681 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 690566007682 ParB-like nuclease domain; Region: ParB; smart00470 690566007683 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566007684 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 690566007685 putative active site [active] 690566007686 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 690566007687 Protein of unknown function (DUF736); Region: DUF736; pfam05284 690566007688 Helix-turn-helix domain; Region: HTH_17; pfam12728 690566007689 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 690566007690 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 690566007691 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 690566007692 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 690566007693 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566007694 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566007695 catalytic residue [active] 690566007696 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 690566007697 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 690566007698 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 690566007699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566007700 Walker A motif; other site 690566007701 ATP binding site [chemical binding]; other site 690566007702 Walker B motif; other site 690566007703 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 690566007704 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566007705 ATP binding site [chemical binding]; other site 690566007706 Walker A motif; other site 690566007707 hexamer interface [polypeptide binding]; other site 690566007708 Walker B motif; other site 690566007709 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 690566007710 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 690566007711 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 690566007712 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 690566007713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566007714 Walker A/P-loop; other site 690566007715 ATP binding site [chemical binding]; other site 690566007716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566007717 Walker B; other site 690566007718 D-loop; other site 690566007719 H-loop/switch region; other site 690566007720 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 690566007721 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 690566007722 conjugal transfer protein TrbL; Provisional; Region: PRK13875 690566007723 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 690566007724 conjugal transfer protein TrbF; Provisional; Region: PRK13872 690566007725 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 690566007726 VirB7 interaction site; other site 690566007727 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 690566007728 Protein of unknown function (DUF2274); Region: DUF2274; pfam10038 690566007729 Protein of unknown function (DUF736); Region: DUF736; cl02303 690566007730 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 690566007731 Helix-turn-helix domain; Region: HTH_17; pfam12728 690566007732 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 690566007733 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 690566007734 active site 690566007735 NTP binding site [chemical binding]; other site 690566007736 metal binding triad [ion binding]; metal-binding site 690566007737 antibiotic binding site [chemical binding]; other site 690566007738 HEPN domain; Region: HEPN; cl00824 690566007739 RelB antitoxin; Region: RelB; cl01171 690566007740 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 690566007741 classical (c) SDRs; Region: SDR_c; cd05233 690566007742 NAD(P) binding site [chemical binding]; other site 690566007743 active site 690566007744 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 690566007745 FAD binding domain; Region: FAD_binding_4; pfam01565 690566007746 hypothetical protein; Validated; Region: PRK08238 690566007747 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 690566007748 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 690566007749 Predicted membrane protein [Function unknown]; Region: COG2246 690566007750 GtrA-like protein; Region: GtrA; pfam04138 690566007751 extended (e) SDRs; Region: SDR_e; cd08946 690566007752 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 690566007753 NAD(P) binding site [chemical binding]; other site 690566007754 active site 690566007755 substrate binding site [chemical binding]; other site 690566007756 hypothetical protein; Provisional; Region: PRK07233 690566007757 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 690566007758 Ligand binding site; other site 690566007759 Putative Catalytic site; other site 690566007760 DXD motif; other site 690566007761 Protein of unknown function DUF86; Region: DUF86; cl01031 690566007762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566007763 Methyltransferase domain; Region: Methyltransf_23; pfam13489 690566007764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566007765 S-adenosylmethionine binding site [chemical binding]; other site 690566007766 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 690566007767 Fic family protein [Function unknown]; Region: COG3177 690566007768 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 690566007769 Fic/DOC family; Region: Fic; pfam02661 690566007770 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 690566007771 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 690566007772 HipA-like N-terminal domain; Region: HipA_N; pfam07805 690566007773 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 690566007774 HipA-like C-terminal domain; Region: HipA_C; pfam07804 690566007775 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 690566007776 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 690566007777 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 690566007778 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 690566007779 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 690566007780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566007781 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 690566007782 putative substrate translocation pore; other site 690566007783 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 690566007784 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 690566007785 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 690566007786 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 690566007787 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566007788 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007789 N-terminal plug; other site 690566007790 ligand-binding site [chemical binding]; other site 690566007791 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566007792 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566007793 Sulfatase; Region: Sulfatase; cl17466 690566007794 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566007795 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 690566007796 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566007797 N-terminal plug; other site 690566007798 ligand-binding site [chemical binding]; other site 690566007799 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566007800 active site 690566007801 DNA binding site [nucleotide binding] 690566007802 Int/Topo IB signature motif; other site 690566007803 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 690566007804 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 690566007805 Response regulator receiver domain; Region: Response_reg; pfam00072 690566007806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007807 active site 690566007808 phosphorylation site [posttranslational modification] 690566007809 intermolecular recognition site; other site 690566007810 dimerization interface [polypeptide binding]; other site 690566007811 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 690566007812 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 690566007813 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 690566007814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007815 active site 690566007816 phosphorylation site [posttranslational modification] 690566007817 dimerization interface [polypeptide binding]; other site 690566007818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 690566007819 Walker A motif; other site 690566007820 ATP binding site [chemical binding]; other site 690566007821 Walker B motif; other site 690566007822 arginine finger; other site 690566007823 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 690566007824 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 690566007825 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 690566007826 aspartate racemase; Region: asp_race; TIGR00035 690566007827 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 690566007828 L11 interface [polypeptide binding]; other site 690566007829 putative EF-Tu interaction site [polypeptide binding]; other site 690566007830 putative EF-G interaction site [polypeptide binding]; other site 690566007831 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 690566007832 23S rRNA interface [nucleotide binding]; other site 690566007833 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 690566007834 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 690566007835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 690566007836 Zn2+ binding site [ion binding]; other site 690566007837 Mg2+ binding site [ion binding]; other site 690566007838 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 690566007839 synthetase active site [active] 690566007840 NTP binding site [chemical binding]; other site 690566007841 metal binding site [ion binding]; metal-binding site 690566007842 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 690566007843 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 690566007844 Predicted transcriptional regulators [Transcription]; Region: COG1733 690566007845 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 690566007846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566007847 Histidine kinase; Region: His_kinase; pfam06580 690566007848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566007849 ATP binding site [chemical binding]; other site 690566007850 Mg2+ binding site [ion binding]; other site 690566007851 G-X-G motif; other site 690566007852 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 690566007853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566007854 active site 690566007855 phosphorylation site [posttranslational modification] 690566007856 intermolecular recognition site; other site 690566007857 dimerization interface [polypeptide binding]; other site 690566007858 LytTr DNA-binding domain; Region: LytTR; smart00850 690566007859 Predicted membrane protein [Function unknown]; Region: COG2246 690566007860 GtrA-like protein; Region: GtrA; pfam04138 690566007861 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 690566007862 nucleoside/Zn binding site; other site 690566007863 dimer interface [polypeptide binding]; other site 690566007864 catalytic motif [active] 690566007865 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 690566007866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 690566007867 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 690566007868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566007869 dimerization interface [polypeptide binding]; other site 690566007870 putative DNA binding site [nucleotide binding]; other site 690566007871 putative Zn2+ binding site [ion binding]; other site 690566007872 Methyltransferase domain; Region: Methyltransf_31; pfam13847 690566007873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566007874 S-adenosylmethionine binding site [chemical binding]; other site 690566007875 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 690566007876 FAD binding site [chemical binding]; other site 690566007877 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 690566007878 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 690566007879 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 690566007880 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 690566007881 substrate binding pocket [chemical binding]; other site 690566007882 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 690566007883 B12 binding site [chemical binding]; other site 690566007884 cobalt ligand [ion binding]; other site 690566007885 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 690566007886 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 690566007887 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566007888 L-aspartate oxidase; Provisional; Region: PRK09077 690566007889 L-aspartate oxidase; Provisional; Region: PRK06175 690566007890 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 690566007891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 690566007892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566007893 Walker A/P-loop; other site 690566007894 ATP binding site [chemical binding]; other site 690566007895 Q-loop/lid; other site 690566007896 ABC transporter signature motif; other site 690566007897 Walker B; other site 690566007898 D-loop; other site 690566007899 H-loop/switch region; other site 690566007900 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 690566007901 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 690566007902 active site 690566007903 substrate binding site [chemical binding]; other site 690566007904 cosubstrate binding site; other site 690566007905 catalytic site [active] 690566007906 Protein of unknown function (DUF419); Region: DUF419; pfam04237 690566007907 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 690566007908 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 690566007909 dimerization interface [polypeptide binding]; other site 690566007910 putative ATP binding site [chemical binding]; other site 690566007911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 690566007912 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 690566007913 polyphosphate kinase; Provisional; Region: PRK05443 690566007914 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 690566007915 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 690566007916 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 690566007917 putative domain interface [polypeptide binding]; other site 690566007918 putative active site [active] 690566007919 catalytic site [active] 690566007920 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 690566007921 putative domain interface [polypeptide binding]; other site 690566007922 putative active site [active] 690566007923 catalytic site [active] 690566007924 exopolyphosphatase; Region: exo_poly_only; TIGR03706 690566007925 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 690566007926 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 690566007927 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 690566007928 feedback inhibition sensing region; other site 690566007929 homohexameric interface [polypeptide binding]; other site 690566007930 nucleotide binding site [chemical binding]; other site 690566007931 N-acetyl-L-glutamate binding site [chemical binding]; other site 690566007932 YGGT family; Region: YGGT; pfam02325 690566007933 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 690566007934 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 690566007935 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 690566007936 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 690566007937 homodimer interface [polypeptide binding]; other site 690566007938 NADP binding site [chemical binding]; other site 690566007939 substrate binding site [chemical binding]; other site 690566007940 MarC family integral membrane protein; Region: MarC; cl00919 690566007941 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 690566007942 putative active site [active] 690566007943 putative outer membrane lipoprotein; Provisional; Region: PRK10510 690566007944 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 690566007945 ligand binding site [chemical binding]; other site 690566007946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 690566007947 Domain of unknown function DUF21; Region: DUF21; pfam01595 690566007948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 690566007949 Transporter associated domain; Region: CorC_HlyC; smart01091 690566007950 active site 690566007951 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 690566007952 Cytochrome c2 [Energy production and conversion]; Region: COG3474 690566007953 prephenate dehydratase; Provisional; Region: PRK11899 690566007954 Prephenate dehydratase; Region: PDT; pfam00800 690566007955 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 690566007956 putative L-Phe binding site [chemical binding]; other site 690566007957 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 690566007958 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 690566007959 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 690566007960 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 690566007961 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 690566007962 catalytic residues [active] 690566007963 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 690566007964 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 690566007965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566007966 sequence-specific DNA binding site [nucleotide binding]; other site 690566007967 salt bridge; other site 690566007968 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 690566007969 Domain of unknown function (DUF955); Region: DUF955; pfam06114 690566007970 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 690566007971 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 690566007972 tetramer interface [polypeptide binding]; other site 690566007973 active site 690566007974 Mg2+/Mn2+ binding site [ion binding]; other site 690566007975 isocitrate lyase; Region: PLN02892 690566007976 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 690566007977 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566007978 putative C-terminal domain interface [polypeptide binding]; other site 690566007979 putative GSH binding site (G-site) [chemical binding]; other site 690566007980 putative dimer interface [polypeptide binding]; other site 690566007981 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 690566007982 putative N-terminal domain interface [polypeptide binding]; other site 690566007983 putative dimer interface [polypeptide binding]; other site 690566007984 putative substrate binding pocket (H-site) [chemical binding]; other site 690566007985 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 690566007986 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 690566007987 substrate binding site [chemical binding]; other site 690566007988 ligand binding site [chemical binding]; other site 690566007989 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 690566007990 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 690566007991 substrate binding site [chemical binding]; other site 690566007992 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 690566007993 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 690566007994 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 690566007995 putative GSH binding site [chemical binding]; other site 690566007996 catalytic residues [active] 690566007997 Penicillinase repressor; Region: Pencillinase_R; pfam03965 690566007998 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 690566007999 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 690566008000 HemN C-terminal domain; Region: HemN_C; pfam06969 690566008001 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 690566008002 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 690566008003 active site 690566008004 dimerization interface [polypeptide binding]; other site 690566008005 ribonuclease PH; Reviewed; Region: rph; PRK00173 690566008006 Ribonuclease PH; Region: RNase_PH_bact; cd11362 690566008007 hexamer interface [polypeptide binding]; other site 690566008008 active site 690566008009 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 690566008010 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 690566008011 GrpE; Region: GrpE; pfam01025 690566008012 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 690566008013 dimer interface [polypeptide binding]; other site 690566008014 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 690566008015 Predicted transcriptional regulators [Transcription]; Region: COG1695 690566008016 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 690566008017 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 690566008018 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 690566008019 active site 690566008020 putative DNA-binding cleft [nucleotide binding]; other site 690566008021 dimer interface [polypeptide binding]; other site 690566008022 hypothetical protein; Validated; Region: PRK00110 690566008023 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 690566008024 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 690566008025 Protein of unknown function (DUF1244); Region: DUF1244; cl01385 690566008026 pyruvate kinase; Provisional; Region: PRK06247 690566008027 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 690566008028 domain interfaces; other site 690566008029 active site 690566008030 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 690566008031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566008032 motif II; other site 690566008033 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 690566008034 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 690566008035 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 690566008036 active site 690566008037 Zn binding site [ion binding]; other site 690566008038 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 690566008039 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 690566008040 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 690566008041 Right handed beta helix region; Region: Beta_helix; pfam13229 690566008042 Uncharacterized conserved protein [Function unknown]; Region: COG2127 690566008043 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 690566008044 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 690566008045 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 690566008046 N- and C-terminal domain interface [polypeptide binding]; other site 690566008047 active site 690566008048 MgATP binding site [chemical binding]; other site 690566008049 catalytic site [active] 690566008050 metal binding site [ion binding]; metal-binding site 690566008051 glycerol binding site [chemical binding]; other site 690566008052 homotetramer interface [polypeptide binding]; other site 690566008053 homodimer interface [polypeptide binding]; other site 690566008054 FBP binding site [chemical binding]; other site 690566008055 protein IIAGlc interface [polypeptide binding]; other site 690566008056 MASE1; Region: MASE1; cl17823 690566008057 PAS domain S-box; Region: sensory_box; TIGR00229 690566008058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566008059 putative active site [active] 690566008060 heme pocket [chemical binding]; other site 690566008061 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566008062 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566008063 metal binding site [ion binding]; metal-binding site 690566008064 active site 690566008065 I-site; other site 690566008066 MerC mercury resistance protein; Region: MerC; pfam03203 690566008067 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 690566008068 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 690566008069 putative active site [active] 690566008070 homoserine dehydrogenase; Provisional; Region: PRK06349 690566008071 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 690566008072 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 690566008073 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 690566008074 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 690566008075 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 690566008076 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 690566008077 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 690566008078 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 690566008079 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 690566008080 PilZ domain; Region: PilZ; cl01260 690566008081 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 690566008082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 690566008083 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 690566008084 Walker A/P-loop; other site 690566008085 ATP binding site [chemical binding]; other site 690566008086 Q-loop/lid; other site 690566008087 ABC transporter signature motif; other site 690566008088 Walker B; other site 690566008089 D-loop; other site 690566008090 H-loop/switch region; other site 690566008091 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 690566008092 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 690566008093 active site 690566008094 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 690566008095 Mechanosensitive ion channel; Region: MS_channel; pfam00924 690566008096 O-Antigen ligase; Region: Wzy_C; cl04850 690566008097 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 690566008098 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 690566008099 Predicted transcriptional regulator [Transcription]; Region: COG2932 690566008100 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 690566008101 Catalytic site [active] 690566008102 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 690566008103 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 690566008104 XdhC Rossmann domain; Region: XdhC_C; pfam13478 690566008105 Protein of unknown function (DUF466); Region: DUF466; pfam04328 690566008106 carbon starvation protein A; Provisional; Region: PRK15015 690566008107 Carbon starvation protein CstA; Region: CstA; pfam02554 690566008108 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 690566008109 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 690566008110 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 690566008111 PhnA protein; Region: PhnA; pfam03831 690566008112 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 690566008113 G1 box; other site 690566008114 GTP/Mg2+ binding site [chemical binding]; other site 690566008115 Switch I region; other site 690566008116 G2 box; other site 690566008117 G3 box; other site 690566008118 Switch II region; other site 690566008119 G4 box; other site 690566008120 G5 box; other site 690566008121 membrane protein insertase; Provisional; Region: PRK01318 690566008122 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 690566008123 Haemolytic domain; Region: Haemolytic; pfam01809 690566008124 Ribonuclease P; Region: Ribonuclease_P; pfam00825 690566008125 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 690566008126 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 690566008127 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 690566008128 catalytic residues [active] 690566008129 Peptidase family M48; Region: Peptidase_M48; cl12018 690566008130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566008131 TPR motif; other site 690566008132 binding surface 690566008133 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 690566008134 ABC1 family; Region: ABC1; cl17513 690566008135 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 690566008136 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566008137 S-adenosylmethionine binding site [chemical binding]; other site 690566008138 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 690566008139 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 690566008140 DNA binding site [nucleotide binding] 690566008141 catalytic residue [active] 690566008142 H2TH interface [polypeptide binding]; other site 690566008143 putative catalytic residues [active] 690566008144 turnover-facilitating residue; other site 690566008145 intercalation triad [nucleotide binding]; other site 690566008146 8OG recognition residue [nucleotide binding]; other site 690566008147 putative reading head residues; other site 690566008148 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 690566008149 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 690566008150 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 690566008151 benzoate transport; Region: 2A0115; TIGR00895 690566008152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008153 putative substrate translocation pore; other site 690566008154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008155 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 690566008156 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 690566008157 CoenzymeA binding site [chemical binding]; other site 690566008158 subunit interaction site [polypeptide binding]; other site 690566008159 PHB binding site; other site 690566008160 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 690566008161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566008162 active site 690566008163 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 690566008164 Amidohydrolase; Region: Amidohydro_2; pfam04909 690566008165 active site 690566008166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 690566008167 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566008168 substrate binding pocket [chemical binding]; other site 690566008169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566008170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008171 putative substrate translocation pore; other site 690566008172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008173 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566008174 classical (c) SDRs; Region: SDR_c; cd05233 690566008175 NAD(P) binding site [chemical binding]; other site 690566008176 active site 690566008177 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 690566008178 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 690566008179 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 690566008180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008181 NAD(P) binding site [chemical binding]; other site 690566008182 active site 690566008183 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 690566008184 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 690566008185 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 690566008186 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 690566008187 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 690566008188 substrate binding pocket [chemical binding]; other site 690566008189 membrane-bound complex binding site; other site 690566008190 hinge residues; other site 690566008191 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008192 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008193 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008194 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 690566008195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566008196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566008197 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 690566008198 putative dimerization interface [polypeptide binding]; other site 690566008199 putative substrate binding pocket [chemical binding]; other site 690566008200 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 690566008201 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566008202 MarR family; Region: MarR; pfam01047 690566008203 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 690566008204 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566008205 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566008206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008207 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 690566008208 putative substrate translocation pore; other site 690566008209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008210 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566008211 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 690566008212 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 690566008213 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 690566008214 Zn2+ binding site [ion binding]; other site 690566008215 Mg2+ binding site [ion binding]; other site 690566008216 Protein of unknown function (DUF461); Region: DUF461; pfam04314 690566008217 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 690566008218 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 690566008219 nucleotide binding site [chemical binding]; other site 690566008220 NEF interaction site [polypeptide binding]; other site 690566008221 SBD interface [polypeptide binding]; other site 690566008222 chaperone protein DnaJ; Provisional; Region: PRK10767 690566008223 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 690566008224 HSP70 interaction site [polypeptide binding]; other site 690566008225 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 690566008226 substrate binding site [polypeptide binding]; other site 690566008227 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 690566008228 Zn binding sites [ion binding]; other site 690566008229 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 690566008230 dimer interface [polypeptide binding]; other site 690566008231 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 690566008232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566008233 S-adenosylmethionine binding site [chemical binding]; other site 690566008234 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 690566008235 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 690566008236 active site 690566008237 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 690566008238 potassium uptake protein; Region: kup; TIGR00794 690566008239 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566008240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566008241 DNA-binding site [nucleotide binding]; DNA binding site 690566008242 FCD domain; Region: FCD; pfam07729 690566008243 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566008244 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 690566008245 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566008246 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566008247 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 690566008248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008249 putative substrate translocation pore; other site 690566008250 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 690566008251 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008252 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566008253 N-terminal plug; other site 690566008254 ligand-binding site [chemical binding]; other site 690566008255 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566008256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566008257 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566008258 acyl-activating enzyme (AAE) consensus motif; other site 690566008259 putative AMP binding site [chemical binding]; other site 690566008260 putative active site [active] 690566008261 acyl-activating enzyme (AAE) consensus motif; other site 690566008262 putative CoA binding site [chemical binding]; other site 690566008263 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566008264 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566008265 ligand binding site [chemical binding]; other site 690566008266 flexible hinge region; other site 690566008267 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 690566008268 PAS domain S-box; Region: sensory_box; TIGR00229 690566008269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566008270 putative active site [active] 690566008271 heme pocket [chemical binding]; other site 690566008272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 690566008273 HWE histidine kinase; Region: HWE_HK; smart00911 690566008274 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566008275 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566008276 ligand binding site [chemical binding]; other site 690566008277 flexible hinge region; other site 690566008278 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 690566008279 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566008280 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566008281 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 690566008282 putative switch regulator; other site 690566008283 non-specific DNA interactions [nucleotide binding]; other site 690566008284 DNA binding site [nucleotide binding] 690566008285 sequence specific DNA binding site [nucleotide binding]; other site 690566008286 putative cAMP binding site [chemical binding]; other site 690566008287 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 690566008288 HWE histidine kinase; Region: HWE_HK; smart00911 690566008289 Hemerythrin-like domain; Region: Hr-like; cd12108 690566008290 Fe binding site [ion binding]; other site 690566008291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 690566008292 classical (c) SDRs; Region: SDR_c; cd05233 690566008293 NAD(P) binding site [chemical binding]; other site 690566008294 active site 690566008295 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 690566008296 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 690566008297 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 690566008298 NAD binding site [chemical binding]; other site 690566008299 catalytic Zn binding site [ion binding]; other site 690566008300 structural Zn binding site [ion binding]; other site 690566008301 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 690566008302 putative hydrophobic ligand binding site [chemical binding]; other site 690566008303 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008304 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008305 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008306 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008307 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008308 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008309 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008310 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 690566008311 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 690566008312 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 690566008313 Autotransporter beta-domain; Region: Autotransporter; pfam03797 690566008314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566008315 TPR repeat; Region: TPR_11; pfam13414 690566008316 binding surface 690566008317 TPR motif; other site 690566008318 TPR repeat; Region: TPR_11; pfam13414 690566008319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566008320 binding surface 690566008321 TPR motif; other site 690566008322 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 690566008323 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 690566008324 enoyl-CoA hydratase; Provisional; Region: PRK06688 690566008325 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008326 substrate binding site [chemical binding]; other site 690566008327 oxyanion hole (OAH) forming residues; other site 690566008328 trimer interface [polypeptide binding]; other site 690566008329 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 690566008330 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 690566008331 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 690566008332 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566008333 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 690566008334 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 690566008335 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 690566008336 dihydroorotase; Validated; Region: pyrC; PRK09357 690566008337 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566008338 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 690566008339 active site 690566008340 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 690566008341 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 690566008342 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 690566008343 putative homodimer interface [polypeptide binding]; other site 690566008344 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 690566008345 heterodimer interface [polypeptide binding]; other site 690566008346 homodimer interface [polypeptide binding]; other site 690566008347 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 690566008348 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 690566008349 23S rRNA interface [nucleotide binding]; other site 690566008350 L7/L12 interface [polypeptide binding]; other site 690566008351 putative thiostrepton binding site; other site 690566008352 L25 interface [polypeptide binding]; other site 690566008353 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 690566008354 mRNA/rRNA interface [nucleotide binding]; other site 690566008355 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 690566008356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 690566008357 ATP binding site [chemical binding]; other site 690566008358 Mg++ binding site [ion binding]; other site 690566008359 motif III; other site 690566008360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 690566008361 nucleotide binding region [chemical binding]; other site 690566008362 ATP-binding site [chemical binding]; other site 690566008363 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 690566008364 RNA binding site [nucleotide binding]; other site 690566008365 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 690566008366 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 690566008367 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 690566008368 TrkA-N domain; Region: TrkA_N; pfam02254 690566008369 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 690566008370 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 690566008371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 690566008372 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 690566008373 GTPase CgtA; Reviewed; Region: obgE; PRK12299 690566008374 GTP1/OBG; Region: GTP1_OBG; pfam01018 690566008375 Obg GTPase; Region: Obg; cd01898 690566008376 G1 box; other site 690566008377 GTP/Mg2+ binding site [chemical binding]; other site 690566008378 Switch I region; other site 690566008379 G2 box; other site 690566008380 G3 box; other site 690566008381 Switch II region; other site 690566008382 G4 box; other site 690566008383 G5 box; other site 690566008384 gamma-glutamyl kinase; Provisional; Region: PRK05429 690566008385 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 690566008386 nucleotide binding site [chemical binding]; other site 690566008387 homotetrameric interface [polypeptide binding]; other site 690566008388 putative phosphate binding site [ion binding]; other site 690566008389 putative allosteric binding site; other site 690566008390 PUA domain; Region: PUA; pfam01472 690566008391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566008392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008393 NAD(P) binding site [chemical binding]; other site 690566008394 active site 690566008395 Hemerythrin-like domain; Region: Hr-like; cd12108 690566008396 Fe binding site [ion binding]; other site 690566008397 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 690566008398 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 690566008399 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 690566008400 active site 690566008401 DNA binding site [nucleotide binding] 690566008402 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 690566008403 DNA binding site [nucleotide binding] 690566008404 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 690566008405 nucleotide binding site [chemical binding]; other site 690566008406 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 690566008407 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 690566008408 putative DNA binding site [nucleotide binding]; other site 690566008409 putative homodimer interface [polypeptide binding]; other site 690566008410 PRC-barrel domain; Region: PRC; pfam05239 690566008411 short chain dehydrogenase; Provisional; Region: PRK06701 690566008412 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 690566008413 NAD binding site [chemical binding]; other site 690566008414 metal binding site [ion binding]; metal-binding site 690566008415 active site 690566008416 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 690566008417 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 690566008418 active site 690566008419 DNA binding site [nucleotide binding] 690566008420 Int/Topo IB signature motif; other site 690566008421 catalytic residues [active] 690566008422 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008423 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566008424 N-terminal plug; other site 690566008425 ligand-binding site [chemical binding]; other site 690566008426 GDYXXLXY protein; Region: GDYXXLXY; cl02066 690566008427 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 690566008428 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008429 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008430 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008431 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 690566008432 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 690566008433 heme binding pocket [chemical binding]; other site 690566008434 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 690566008435 domain interactions; other site 690566008436 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 690566008437 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566008438 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 690566008439 active site 690566008440 DNA binding site [nucleotide binding] 690566008441 Int/Topo IB signature motif; other site 690566008442 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566008443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566008444 active site 690566008445 phosphorylation site [posttranslational modification] 690566008446 intermolecular recognition site; other site 690566008447 dimerization interface [polypeptide binding]; other site 690566008448 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 690566008449 Peptidase family M23; Region: Peptidase_M23; pfam01551 690566008450 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 690566008451 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566008452 E3 interaction surface; other site 690566008453 lipoyl attachment site [posttranslational modification]; other site 690566008454 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566008455 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 690566008456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 690566008457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566008458 Walker A/P-loop; other site 690566008459 ATP binding site [chemical binding]; other site 690566008460 Q-loop/lid; other site 690566008461 ABC transporter signature motif; other site 690566008462 Walker B; other site 690566008463 D-loop; other site 690566008464 H-loop/switch region; other site 690566008465 Outer membrane efflux protein; Region: OEP; pfam02321 690566008466 Predicted transcriptional regulator [Transcription]; Region: COG4190 690566008467 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 690566008468 active site 690566008469 catalytic site [active] 690566008470 substrate binding site [chemical binding]; other site 690566008471 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 690566008472 HTH-like domain; Region: HTH_21; pfam13276 690566008473 Integrase core domain; Region: rve; pfam00665 690566008474 Integrase core domain; Region: rve_3; pfam13683 690566008475 Transposase; Region: HTH_Tnp_1; cl17663 690566008476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 690566008477 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566008478 MarR family; Region: MarR_2; pfam12802 690566008479 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 690566008480 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 690566008481 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 690566008482 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 690566008483 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 690566008484 ligand binding site [chemical binding]; other site 690566008485 homodimer interface [polypeptide binding]; other site 690566008486 NAD(P) binding site [chemical binding]; other site 690566008487 trimer interface B [polypeptide binding]; other site 690566008488 trimer interface A [polypeptide binding]; other site 690566008489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 690566008490 DNA-binding site [nucleotide binding]; DNA binding site 690566008491 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 690566008492 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 690566008493 active site 690566008494 dimer interface [polypeptide binding]; other site 690566008495 metal binding site [ion binding]; metal-binding site 690566008496 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 690566008497 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566008498 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 690566008499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566008500 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 690566008501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566008502 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 690566008503 substrate binding pocket [chemical binding]; other site 690566008504 dimerization interface [polypeptide binding]; other site 690566008505 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 690566008506 CoenzymeA binding site [chemical binding]; other site 690566008507 subunit interaction site [polypeptide binding]; other site 690566008508 PHB binding site; other site 690566008509 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 690566008510 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 690566008511 beta-ketothiolase; Provisional; Region: PRK09051 690566008512 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566008513 dimer interface [polypeptide binding]; other site 690566008514 active site 690566008515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566008516 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566008517 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 690566008518 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 690566008519 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566008520 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566008521 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 690566008522 enoyl-CoA hydratase; Provisional; Region: PRK12478 690566008523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008524 substrate binding site [chemical binding]; other site 690566008525 oxyanion hole (OAH) forming residues; other site 690566008526 trimer interface [polypeptide binding]; other site 690566008527 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 690566008528 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 690566008529 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 690566008530 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566008531 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566008532 acyl-activating enzyme (AAE) consensus motif; other site 690566008533 putative AMP binding site [chemical binding]; other site 690566008534 putative active site [active] 690566008535 putative CoA binding site [chemical binding]; other site 690566008536 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 690566008537 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 690566008538 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 690566008539 dimerization interface [polypeptide binding]; other site 690566008540 active site 690566008541 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 690566008542 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566008543 catalytic loop [active] 690566008544 iron binding site [ion binding]; other site 690566008545 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 690566008546 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566008547 Cytochrome P450; Region: p450; cl12078 690566008548 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566008549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008550 NAD(P) binding site [chemical binding]; other site 690566008551 active site 690566008552 enoyl-CoA hydratase; Provisional; Region: PRK06494 690566008553 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008554 substrate binding site [chemical binding]; other site 690566008555 oxyanion hole (OAH) forming residues; other site 690566008556 trimer interface [polypeptide binding]; other site 690566008557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008558 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566008559 NAD(P) binding site [chemical binding]; other site 690566008560 active site 690566008561 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566008562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 690566008563 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008564 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008565 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008566 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566008567 N-terminal plug; other site 690566008568 ligand-binding site [chemical binding]; other site 690566008569 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566008570 Sulfatase; Region: Sulfatase; pfam00884 690566008571 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 690566008572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566008573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566008574 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 690566008575 putative catalytic residues [active] 690566008576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566008577 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 690566008578 tetramerization interface [polypeptide binding]; other site 690566008579 NAD(P) binding site [chemical binding]; other site 690566008580 catalytic residues [active] 690566008581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008582 D-galactonate transporter; Region: 2A0114; TIGR00893 690566008583 putative substrate translocation pore; other site 690566008584 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 690566008585 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 690566008586 galactarate dehydratase; Region: galactar-dH20; TIGR03248 690566008587 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 690566008588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566008589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566008590 DNA binding site [nucleotide binding] 690566008591 domain linker motif; other site 690566008592 Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545 690566008593 putative dimerization interface [polypeptide binding]; other site 690566008594 putative ligand binding site [chemical binding]; other site 690566008595 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 690566008596 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 690566008597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008598 NAD(P) binding site [chemical binding]; other site 690566008599 active site 690566008600 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 690566008601 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 690566008602 substrate binding site [chemical binding]; other site 690566008603 ATP binding site [chemical binding]; other site 690566008604 Cupin domain; Region: Cupin_2; pfam07883 690566008605 Pectate lyase; Region: Pec_lyase_C; cl01593 690566008606 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 690566008607 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 690566008608 glucuronate isomerase; Reviewed; Region: PRK02925 690566008609 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 690566008610 D-mannonate oxidoreductase; Provisional; Region: PRK15037 690566008611 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 690566008612 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 690566008613 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 690566008614 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 690566008615 putative active site [active] 690566008616 catalytic residue [active] 690566008617 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 690566008618 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 690566008619 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 690566008620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566008621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566008622 dimerization interface [polypeptide binding]; other site 690566008623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008624 D-galactonate transporter; Region: 2A0114; TIGR00893 690566008625 putative substrate translocation pore; other site 690566008626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008627 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 690566008628 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008629 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008630 putative pectinesterase; Region: PLN02432; cl01911 690566008631 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 690566008632 active site 690566008633 SIR2-like domain; Region: SIR2_2; pfam13289 690566008634 multiple promoter invertase; Provisional; Region: mpi; PRK13413 690566008635 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 690566008636 catalytic residues [active] 690566008637 catalytic nucleophile [active] 690566008638 Presynaptic Site I dimer interface [polypeptide binding]; other site 690566008639 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 690566008640 Synaptic Flat tetramer interface [polypeptide binding]; other site 690566008641 Synaptic Site I dimer interface [polypeptide binding]; other site 690566008642 DNA binding site [nucleotide binding] 690566008643 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 690566008644 DNA-binding interface [nucleotide binding]; DNA binding site 690566008645 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 690566008646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566008647 active site 690566008648 DNA binding site [nucleotide binding] 690566008649 Int/Topo IB signature motif; other site 690566008650 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 690566008651 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 690566008652 VacJ like lipoprotein; Region: VacJ; cl01073 690566008653 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 690566008654 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 690566008655 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 690566008656 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 690566008657 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 690566008658 ApbE family; Region: ApbE; pfam02424 690566008659 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 690566008660 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 690566008661 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 690566008662 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 690566008663 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008664 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008665 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 690566008666 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 690566008667 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 690566008668 NAD(P) binding site [chemical binding]; other site 690566008669 homotetramer interface [polypeptide binding]; other site 690566008670 homodimer interface [polypeptide binding]; other site 690566008671 active site 690566008672 ferrochelatase; Reviewed; Region: hemH; PRK00035 690566008673 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 690566008674 C-terminal domain interface [polypeptide binding]; other site 690566008675 active site 690566008676 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 690566008677 active site 690566008678 N-terminal domain interface [polypeptide binding]; other site 690566008679 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 690566008680 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 690566008681 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 690566008682 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 690566008683 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 690566008684 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 690566008685 Walker A motif; other site 690566008686 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 690566008687 HflK protein; Region: hflK; TIGR01933 690566008688 HflC protein; Region: hflC; TIGR01932 690566008689 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 690566008690 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 690566008691 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 690566008692 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 690566008693 protein binding site [polypeptide binding]; other site 690566008694 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 690566008695 protein binding site [polypeptide binding]; other site 690566008696 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 690566008697 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 690566008698 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566008699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566008700 DNA binding residues [nucleotide binding] 690566008701 dimerization interface [polypeptide binding]; other site 690566008702 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008703 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566008704 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 690566008705 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 690566008706 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 690566008707 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 690566008708 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 690566008709 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 690566008710 RPB3 interaction site [polypeptide binding]; other site 690566008711 RPB1 interaction site [polypeptide binding]; other site 690566008712 RPB11 interaction site [polypeptide binding]; other site 690566008713 RPB10 interaction site [polypeptide binding]; other site 690566008714 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 690566008715 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 690566008716 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 690566008717 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 690566008718 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 690566008719 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 690566008720 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 690566008721 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 690566008722 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 690566008723 DNA binding site [nucleotide binding] 690566008724 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 690566008725 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 690566008726 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 690566008727 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 690566008728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566008729 non-specific DNA binding site [nucleotide binding]; other site 690566008730 salt bridge; other site 690566008731 sequence-specific DNA binding site [nucleotide binding]; other site 690566008732 Helix-turn-helix domain; Region: HTH_17; cl17695 690566008733 Helix-turn-helix domain; Region: HTH_17; pfam12728 690566008734 Helix-turn-helix domain; Region: HTH_17; cl17695 690566008735 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 690566008736 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 690566008737 Int/Topo IB signature motif; other site 690566008738 Fic family protein [Function unknown]; Region: COG3177 690566008739 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 690566008740 Fic/DOC family; Region: Fic; pfam02661 690566008741 Abi-like protein; Region: Abi_2; pfam07751 690566008742 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 690566008743 Catalytic site; other site 690566008744 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 690566008745 Gram-negative bacterial tonB protein; Region: TonB; cl10048 690566008746 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 690566008747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 690566008748 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566008749 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 690566008750 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 690566008751 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 690566008752 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008753 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566008754 N-terminal plug; other site 690566008755 ligand-binding site [chemical binding]; other site 690566008756 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 690566008757 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 690566008758 DNA binding residues [nucleotide binding] 690566008759 putative dimer interface [polypeptide binding]; other site 690566008760 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 690566008761 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 690566008762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566008763 active site 690566008764 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 690566008765 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 690566008766 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 690566008767 dimer interface [polypeptide binding]; other site 690566008768 putative CheW interface [polypeptide binding]; other site 690566008769 EamA-like transporter family; Region: EamA; pfam00892 690566008770 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 690566008771 putative active site [active] 690566008772 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 690566008773 Fumarase C-terminus; Region: Fumerase_C; pfam05683 690566008774 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566008775 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 690566008776 C-terminal domain interface [polypeptide binding]; other site 690566008777 GSH binding site (G-site) [chemical binding]; other site 690566008778 dimer interface [polypeptide binding]; other site 690566008779 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 690566008780 N-terminal domain interface [polypeptide binding]; other site 690566008781 dimer interface [polypeptide binding]; other site 690566008782 substrate binding pocket (H-site) [chemical binding]; other site 690566008783 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 690566008784 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 690566008785 Class I ribonucleotide reductase; Region: RNR_I; cd01679 690566008786 active site 690566008787 dimer interface [polypeptide binding]; other site 690566008788 catalytic residues [active] 690566008789 effector binding site; other site 690566008790 R2 peptide binding site; other site 690566008791 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 690566008792 putative active site [active] 690566008793 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 690566008794 dimer interface [polypeptide binding]; other site 690566008795 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 690566008796 putative radical transfer pathway; other site 690566008797 diiron center [ion binding]; other site 690566008798 tyrosyl radical; other site 690566008799 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 690566008800 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 690566008801 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 690566008802 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 690566008803 Catalytic site; other site 690566008804 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 690566008805 heme-binding site [chemical binding]; other site 690566008806 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 690566008807 active site 690566008808 catalytic residues [active] 690566008809 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 690566008810 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 690566008811 Zn2+ binding site [ion binding]; other site 690566008812 Mg2+ binding site [ion binding]; other site 690566008813 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 690566008814 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 690566008815 MerR family regulatory protein; Region: MerR; pfam00376 690566008816 DNA binding residues [nucleotide binding] 690566008817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566008818 P-loop; other site 690566008819 Magnesium ion binding site [ion binding]; other site 690566008820 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566008821 Magnesium ion binding site [ion binding]; other site 690566008822 ParB-like nuclease domain; Region: ParBc; pfam02195 690566008823 Replication initiator protein A; Region: RPA; pfam10134 690566008824 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 690566008825 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 690566008826 IHF - DNA interface [nucleotide binding]; other site 690566008827 IHF dimer interface [polypeptide binding]; other site 690566008828 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 690566008829 Surface antigen; Region: Bac_surface_Ag; pfam01103 690566008830 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 690566008831 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566008832 ParB-like nuclease domain; Region: ParB; smart00470 690566008833 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 690566008834 Predicted membrane protein [Function unknown]; Region: COG4655 690566008835 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 690566008836 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 690566008837 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 690566008838 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 690566008839 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 690566008840 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566008841 ATP binding site [chemical binding]; other site 690566008842 Walker A motif; other site 690566008843 hexamer interface [polypeptide binding]; other site 690566008844 Walker B motif; other site 690566008845 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 690566008846 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 690566008847 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 690566008848 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 690566008849 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 690566008850 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 690566008851 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 690566008852 dimer interface [polypeptide binding]; other site 690566008853 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 690566008854 active site 690566008855 Fe binding site [ion binding]; other site 690566008856 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 690566008857 cofactor binding site; other site 690566008858 metal binding site [ion binding]; metal-binding site 690566008859 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566008860 Cytochrome P450; Region: p450; cl12078 690566008861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 690566008862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566008863 DNA-binding site [nucleotide binding]; DNA binding site 690566008864 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 690566008865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566008867 NAD(P) binding site [chemical binding]; other site 690566008868 active site 690566008869 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566008870 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566008871 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566008872 N-terminal plug; other site 690566008873 ligand-binding site [chemical binding]; other site 690566008874 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 690566008875 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 690566008876 dimer interface [polypeptide binding]; other site 690566008877 PYR/PP interface [polypeptide binding]; other site 690566008878 TPP binding site [chemical binding]; other site 690566008879 substrate binding site [chemical binding]; other site 690566008880 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 690566008881 TPP-binding site [chemical binding]; other site 690566008882 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 690566008883 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 690566008884 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566008885 FAD binding site [chemical binding]; other site 690566008886 substrate binding pocket [chemical binding]; other site 690566008887 catalytic base [active] 690566008888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008889 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566008890 putative substrate translocation pore; other site 690566008891 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566008892 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566008893 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 690566008894 putative FMN binding site [chemical binding]; other site 690566008895 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 690566008896 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566008897 lipid-transfer protein; Provisional; Region: PRK07855 690566008898 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566008899 active site 690566008900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566008901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566008902 Amidohydrolase; Region: Amidohydro_2; pfam04909 690566008903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566008904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566008905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566008906 dimerization interface [polypeptide binding]; other site 690566008907 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566008908 classical (c) SDRs; Region: SDR_c; cd05233 690566008909 NAD(P) binding site [chemical binding]; other site 690566008910 active site 690566008911 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 690566008912 Transmembrane secretion effector; Region: MFS_3; pfam05977 690566008913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566008914 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566008915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566008916 DNA binding residues [nucleotide binding] 690566008917 dimerization interface [polypeptide binding]; other site 690566008918 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566008919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566008920 active site 690566008921 enoyl-CoA hydratase; Provisional; Region: PRK08252 690566008922 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008923 substrate binding site [chemical binding]; other site 690566008924 oxyanion hole (OAH) forming residues; other site 690566008925 trimer interface [polypeptide binding]; other site 690566008926 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566008927 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566008928 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 690566008929 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566008930 dimer interface [polypeptide binding]; other site 690566008931 active site 690566008932 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 690566008933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008934 NAD(P) binding site [chemical binding]; other site 690566008935 active site 690566008936 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 690566008937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566008938 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 690566008939 Transcriptional regulators [Transcription]; Region: MarR; COG1846 690566008940 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 690566008941 enoyl-CoA hydratase; Provisional; Region: PRK08140 690566008942 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008943 substrate binding site [chemical binding]; other site 690566008944 oxyanion hole (OAH) forming residues; other site 690566008945 trimer interface [polypeptide binding]; other site 690566008946 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 690566008947 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 690566008948 active site 690566008949 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 690566008950 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566008951 NAD binding site [chemical binding]; other site 690566008952 catalytic residues [active] 690566008953 SnoaL-like domain; Region: SnoaL_3; pfam13474 690566008954 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566008955 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 690566008956 catalytic site [active] 690566008957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008958 substrate binding site [chemical binding]; other site 690566008959 oxyanion hole (OAH) forming residues; other site 690566008960 trimer interface [polypeptide binding]; other site 690566008961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566008962 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 690566008963 NAD(P) binding site [chemical binding]; other site 690566008964 active site 690566008965 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566008966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566008967 active site 690566008968 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566008969 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566008970 active site 690566008971 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566008972 enoyl-CoA hydratase; Provisional; Region: PRK06688 690566008973 substrate binding site [chemical binding]; other site 690566008974 oxyanion hole (OAH) forming residues; other site 690566008975 trimer interface [polypeptide binding]; other site 690566008976 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566008977 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 690566008978 dimer interface [polypeptide binding]; other site 690566008979 active site 690566008980 metal binding site [ion binding]; metal-binding site 690566008981 glutathione binding site [chemical binding]; other site 690566008982 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 690566008983 FAD binding domain; Region: FAD_binding_4; pfam01565 690566008984 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566008985 classical (c) SDRs; Region: SDR_c; cd05233 690566008986 NAD(P) binding site [chemical binding]; other site 690566008987 active site 690566008988 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566008989 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566008990 [2Fe-2S] cluster binding site [ion binding]; other site 690566008991 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 690566008992 hydrophobic ligand binding site; other site 690566008993 EthD domain; Region: EthD; pfam07110 690566008994 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566008995 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566008996 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566008997 short chain dehydrogenase; Provisional; Region: PRK12939 690566008998 classical (c) SDRs; Region: SDR_c; cd05233 690566008999 NAD(P) binding site [chemical binding]; other site 690566009000 active site 690566009001 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 690566009002 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 690566009003 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 690566009004 Trp docking motif [polypeptide binding]; other site 690566009005 putative active site [active] 690566009006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009007 classical (c) SDRs; Region: SDR_c; cd05233 690566009008 NAD(P) binding site [chemical binding]; other site 690566009009 active site 690566009010 hypothetical protein; Provisional; Region: PRK06194 690566009011 classical (c) SDRs; Region: SDR_c; cd05233 690566009012 NAD(P) binding site [chemical binding]; other site 690566009013 active site 690566009014 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566009015 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009016 classical (c) SDRs; Region: SDR_c; cd05233 690566009017 NAD(P) binding site [chemical binding]; other site 690566009018 active site 690566009019 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 690566009020 Phosphotransferase enzyme family; Region: APH; pfam01636 690566009021 active site 690566009022 substrate binding site [chemical binding]; other site 690566009023 ATP binding site [chemical binding]; other site 690566009024 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 690566009025 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009027 NAD(P) binding site [chemical binding]; other site 690566009028 active site 690566009029 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566009030 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 690566009031 FMN binding site [chemical binding]; other site 690566009032 active site 690566009033 substrate binding site [chemical binding]; other site 690566009034 catalytic residue [active] 690566009035 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009036 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009037 N-terminal plug; other site 690566009038 ligand-binding site [chemical binding]; other site 690566009039 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 690566009040 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 690566009041 Trp docking motif [polypeptide binding]; other site 690566009042 putative active site [active] 690566009043 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 690566009044 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009045 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009046 N-terminal plug; other site 690566009047 ligand-binding site [chemical binding]; other site 690566009048 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 690566009049 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 690566009050 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566009051 tetramer interface [polypeptide binding]; other site 690566009052 TPP-binding site [chemical binding]; other site 690566009053 heterodimer interface [polypeptide binding]; other site 690566009054 phosphorylation loop region [posttranslational modification] 690566009055 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 690566009056 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566009057 alpha subunit interface [polypeptide binding]; other site 690566009058 TPP binding site [chemical binding]; other site 690566009059 heterodimer interface [polypeptide binding]; other site 690566009060 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566009061 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 690566009062 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566009063 E3 interaction surface; other site 690566009064 lipoyl attachment site [posttranslational modification]; other site 690566009065 e3 binding domain; Region: E3_binding; pfam02817 690566009066 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566009067 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 690566009068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566009069 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 690566009070 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 690566009071 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 690566009072 substrate binding site [chemical binding]; other site 690566009073 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 690566009074 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 690566009075 substrate binding site [chemical binding]; other site 690566009076 ligand binding site [chemical binding]; other site 690566009077 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566009078 Cytochrome P450; Region: p450; cl12078 690566009079 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 690566009080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566009081 DNA-binding site [nucleotide binding]; DNA binding site 690566009082 FCD domain; Region: FCD; pfam07729 690566009083 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 690566009084 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 690566009085 Helix-turn-helix domain; Region: HTH_38; pfam13936 690566009086 Integrase core domain; Region: rve; pfam00665 690566009087 sorbitol dehydrogenase; Provisional; Region: PRK07067 690566009088 classical (c) SDRs; Region: SDR_c; cd05233 690566009089 NAD(P) binding site [chemical binding]; other site 690566009090 active site 690566009091 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 690566009092 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566009093 acyl-activating enzyme (AAE) consensus motif; other site 690566009094 AMP binding site [chemical binding]; other site 690566009095 active site 690566009096 CoA binding site [chemical binding]; other site 690566009097 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 690566009098 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566009099 putative AMP binding site [chemical binding]; other site 690566009100 putative active site [active] 690566009101 acyl-activating enzyme (AAE) consensus motif; other site 690566009102 putative CoA binding site [chemical binding]; other site 690566009103 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 690566009104 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 690566009105 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 690566009106 tartrate dehydrogenase; Region: TTC; TIGR02089 690566009107 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 690566009108 SnoaL-like domain; Region: SnoaL_3; pfam13474 690566009109 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 690566009110 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566009111 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 690566009112 active site 690566009113 metal binding site [ion binding]; metal-binding site 690566009114 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 690566009115 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 690566009116 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 690566009117 Trp docking motif [polypeptide binding]; other site 690566009118 putative active site [active] 690566009119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566009120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566009121 putative substrate translocation pore; other site 690566009122 hypothetical protein; Provisional; Region: PRK06194 690566009123 classical (c) SDRs; Region: SDR_c; cd05233 690566009124 NAD(P) binding site [chemical binding]; other site 690566009125 active site 690566009126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566009127 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566009128 enoyl-CoA hydratase; Provisional; Region: PRK06495 690566009129 substrate binding site [chemical binding]; other site 690566009130 oxyanion hole (OAH) forming residues; other site 690566009131 trimer interface [polypeptide binding]; other site 690566009132 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 690566009133 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009134 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009135 N-terminal plug; other site 690566009136 ligand-binding site [chemical binding]; other site 690566009137 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566009138 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009139 classical (c) SDRs; Region: SDR_c; cd05233 690566009140 NAD(P) binding site [chemical binding]; other site 690566009141 active site 690566009142 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566009143 Sulfatase; Region: Sulfatase; pfam00884 690566009144 Uncharacterized conserved protein [Function unknown]; Region: COG1262 690566009145 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 690566009146 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009147 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009148 N-terminal plug; other site 690566009149 ligand-binding site [chemical binding]; other site 690566009150 Transposase; Region: DEDD_Tnp_IS110; pfam01548 690566009151 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009152 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009153 N-terminal plug; other site 690566009154 ligand-binding site [chemical binding]; other site 690566009155 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 690566009156 Sulfatase; Region: Sulfatase; pfam00884 690566009157 Sulfatase; Region: Sulfatase; pfam00884 690566009158 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 690566009159 Sulfatase; Region: Sulfatase; cl17466 690566009160 HEAT repeats; Region: HEAT_2; pfam13646 690566009161 Uncharacterized conserved protein [Function unknown]; Region: COG1262 690566009162 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 690566009163 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 690566009164 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 690566009165 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566009166 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 690566009167 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566009168 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566009169 DNA binding site [nucleotide binding] 690566009170 domain linker motif; other site 690566009171 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 690566009172 dimerization interface [polypeptide binding]; other site 690566009173 ligand binding site [chemical binding]; other site 690566009174 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 690566009175 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 690566009176 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 690566009177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 690566009178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 690566009179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 690566009180 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 690566009181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566009182 putative substrate translocation pore; other site 690566009183 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 690566009184 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 690566009185 substrate binding pocket [chemical binding]; other site 690566009186 catalytic triad [active] 690566009187 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566009188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566009189 putative DNA binding site [nucleotide binding]; other site 690566009190 putative Zn2+ binding site [ion binding]; other site 690566009191 AsnC family; Region: AsnC_trans_reg; pfam01037 690566009192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009193 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009194 NAD(P) binding site [chemical binding]; other site 690566009195 active site 690566009196 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566009197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566009198 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 690566009199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009200 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009201 NAD(P) binding site [chemical binding]; other site 690566009202 active site 690566009203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566009204 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009205 classical (c) SDRs; Region: SDR_c; cd05233 690566009206 NAD(P) binding site [chemical binding]; other site 690566009207 active site 690566009208 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009209 classical (c) SDRs; Region: SDR_c; cd05233 690566009210 NAD(P) binding site [chemical binding]; other site 690566009211 active site 690566009212 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009213 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566009214 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 690566009215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009216 NAD(P) binding site [chemical binding]; other site 690566009217 active site 690566009218 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 690566009219 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 690566009220 DNA interaction; other site 690566009221 Metal-binding active site; metal-binding site 690566009222 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 690566009223 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566009224 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 690566009225 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 690566009226 PYR/PP interface [polypeptide binding]; other site 690566009227 dimer interface [polypeptide binding]; other site 690566009228 TPP binding site [chemical binding]; other site 690566009229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 690566009230 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 690566009231 TPP-binding site [chemical binding]; other site 690566009232 MarR family; Region: MarR_2; pfam12802 690566009233 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566009234 Cytochrome P450; Region: p450; cl12078 690566009235 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 690566009236 Cupin domain; Region: Cupin_2; pfam07883 690566009237 Cupin domain; Region: Cupin_2; pfam07883 690566009238 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 690566009239 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566009240 maleylacetoacetate isomerase; Region: maiA; TIGR01262 690566009241 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 690566009242 C-terminal domain interface [polypeptide binding]; other site 690566009243 GSH binding site (G-site) [chemical binding]; other site 690566009244 putative dimer interface [polypeptide binding]; other site 690566009245 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 690566009246 N-terminal domain interface [polypeptide binding]; other site 690566009247 dimer interface [polypeptide binding]; other site 690566009248 substrate binding pocket (H-site) [chemical binding]; other site 690566009249 UTRA domain; Region: UTRA; pfam07702 690566009250 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 690566009251 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 690566009252 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566009253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566009254 DNA-binding site [nucleotide binding]; DNA binding site 690566009255 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 690566009256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009257 NAD(P) binding site [chemical binding]; other site 690566009258 short chain dehydrogenase; Validated; Region: PRK07069 690566009259 active site 690566009260 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566009261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566009262 active site 690566009263 response regulator FixJ; Provisional; Region: fixJ; PRK09390 690566009264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009265 active site 690566009266 phosphorylation site [posttranslational modification] 690566009267 intermolecular recognition site; other site 690566009268 dimerization interface [polypeptide binding]; other site 690566009269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566009270 DNA binding residues [nucleotide binding] 690566009271 dimerization interface [polypeptide binding]; other site 690566009272 PAS domain S-box; Region: sensory_box; TIGR00229 690566009273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566009274 putative active site [active] 690566009275 heme pocket [chemical binding]; other site 690566009276 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566009277 dimer interface [polypeptide binding]; other site 690566009278 phosphorylation site [posttranslational modification] 690566009279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566009280 ATP binding site [chemical binding]; other site 690566009281 Mg2+ binding site [ion binding]; other site 690566009282 G-X-G motif; other site 690566009283 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 690566009284 Ligand Binding Site [chemical binding]; other site 690566009285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 690566009286 Ligand Binding Site [chemical binding]; other site 690566009287 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 690566009288 elongation factor G; Reviewed; Region: PRK12740 690566009289 G1 box; other site 690566009290 putative GEF interaction site [polypeptide binding]; other site 690566009291 GTP/Mg2+ binding site [chemical binding]; other site 690566009292 Switch I region; other site 690566009293 G2 box; other site 690566009294 G3 box; other site 690566009295 Switch II region; other site 690566009296 G4 box; other site 690566009297 G5 box; other site 690566009298 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 690566009299 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 690566009300 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 690566009301 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009302 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009303 N-terminal plug; other site 690566009304 ligand-binding site [chemical binding]; other site 690566009305 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 690566009306 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 690566009307 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 690566009308 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 690566009309 tetrameric interface [polypeptide binding]; other site 690566009310 NAD binding site [chemical binding]; other site 690566009311 catalytic residues [active] 690566009312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566009315 dimerization interface [polypeptide binding]; other site 690566009316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566009317 S-adenosylmethionine binding site [chemical binding]; other site 690566009318 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009319 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009320 N-terminal plug; other site 690566009321 ligand-binding site [chemical binding]; other site 690566009322 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 690566009323 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 690566009324 active site 690566009325 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 690566009326 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 690566009327 CysD dimerization site [polypeptide binding]; other site 690566009328 G1 box; other site 690566009329 putative GEF interaction site [polypeptide binding]; other site 690566009330 GTP/Mg2+ binding site [chemical binding]; other site 690566009331 Switch I region; other site 690566009332 G2 box; other site 690566009333 G3 box; other site 690566009334 Switch II region; other site 690566009335 G4 box; other site 690566009336 G5 box; other site 690566009337 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 690566009338 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 690566009339 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 690566009340 ligand-binding site [chemical binding]; other site 690566009341 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 690566009342 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 690566009343 Active Sites [active] 690566009344 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 690566009345 dimerization interface [polypeptide binding]; other site 690566009346 DNA binding residues [nucleotide binding] 690566009347 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 690566009348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 690566009349 FeS/SAM binding site; other site 690566009350 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566009351 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 690566009352 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566009353 acyl-activating enzyme (AAE) consensus motif; other site 690566009354 acyl-activating enzyme (AAE) consensus motif; other site 690566009355 putative AMP binding site [chemical binding]; other site 690566009356 putative active site [active] 690566009357 putative CoA binding site [chemical binding]; other site 690566009358 CoA binding site [chemical binding]; other site 690566009359 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 690566009360 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566009361 dimer interface [polypeptide binding]; other site 690566009362 active site 690566009363 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566009364 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 690566009365 NAD(P) binding site [chemical binding]; other site 690566009366 catalytic residues [active] 690566009367 enoyl-CoA hydratase; Provisional; Region: PRK08260 690566009368 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566009369 substrate binding site [chemical binding]; other site 690566009370 oxyanion hole (OAH) forming residues; other site 690566009371 trimer interface [polypeptide binding]; other site 690566009372 short chain dehydrogenase; Provisional; Region: PRK07576 690566009373 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 690566009374 NAD(P) binding site [chemical binding]; other site 690566009375 substrate binding site [chemical binding]; other site 690566009376 homotetramer interface [polypeptide binding]; other site 690566009377 active site 690566009378 homodimer interface [polypeptide binding]; other site 690566009379 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566009380 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566009381 substrate binding site [chemical binding]; other site 690566009382 oxyanion hole (OAH) forming residues; other site 690566009383 trimer interface [polypeptide binding]; other site 690566009384 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566009385 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566009386 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566009387 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566009388 Cytochrome P450; Region: p450; cl12078 690566009389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566009392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566009393 active site 690566009394 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 690566009395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566009396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566009397 dimer interface [polypeptide binding]; other site 690566009398 phosphorylation site [posttranslational modification] 690566009399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566009400 ATP binding site [chemical binding]; other site 690566009401 Mg2+ binding site [ion binding]; other site 690566009402 G-X-G motif; other site 690566009403 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 690566009404 Autotransporter beta-domain; Region: Autotransporter; smart00869 690566009405 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 690566009406 amidohydrolase; Region: amidohydrolases; TIGR01891 690566009407 putative metal binding site [ion binding]; other site 690566009408 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 690566009409 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 690566009410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566009411 ligand binding site [chemical binding]; other site 690566009412 flexible hinge region; other site 690566009413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 690566009414 non-specific DNA interactions [nucleotide binding]; other site 690566009415 DNA binding site [nucleotide binding] 690566009416 sequence specific DNA binding site [nucleotide binding]; other site 690566009417 putative cAMP binding site [chemical binding]; other site 690566009418 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 690566009419 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 690566009420 Low-spin heme binding site [chemical binding]; other site 690566009421 Putative water exit pathway; other site 690566009422 Binuclear center (active site) [active] 690566009423 Putative proton exit pathway; other site 690566009424 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 690566009425 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 690566009426 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 690566009427 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 690566009428 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566009429 Cytochrome c; Region: Cytochrom_C; pfam00034 690566009430 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 690566009431 4Fe-4S binding domain; Region: Fer4_5; pfam12801 690566009432 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 690566009433 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 690566009434 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 690566009435 FixH; Region: FixH; pfam05751 690566009436 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 690566009437 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 690566009438 metal-binding site [ion binding] 690566009439 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 690566009440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566009441 motif II; other site 690566009442 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 690566009443 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 690566009444 active site 690566009445 catalytic triad [active] 690566009446 oxyanion hole [active] 690566009447 switch loop; other site 690566009448 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 690566009449 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 690566009450 Walker A/P-loop; other site 690566009451 ATP binding site [chemical binding]; other site 690566009452 Q-loop/lid; other site 690566009453 ABC transporter signature motif; other site 690566009454 Walker B; other site 690566009455 D-loop; other site 690566009456 H-loop/switch region; other site 690566009457 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 690566009458 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 690566009459 Response regulator receiver domain; Region: Response_reg; pfam00072 690566009460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009461 active site 690566009462 phosphorylation site [posttranslational modification] 690566009463 intermolecular recognition site; other site 690566009464 dimerization interface [polypeptide binding]; other site 690566009465 Tetratricopeptide repeat; Region: TPR_16; pfam13432 690566009466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566009467 TPR motif; other site 690566009468 binding surface 690566009469 HEAT repeats; Region: HEAT_2; pfam13646 690566009470 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 690566009471 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 690566009472 DXD motif; other site 690566009473 GAF domain; Region: GAF_3; pfam13492 690566009474 GAF domain; Region: GAF_2; pfam13185 690566009475 PAS domain S-box; Region: sensory_box; TIGR00229 690566009476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566009477 putative active site [active] 690566009478 heme pocket [chemical binding]; other site 690566009479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566009480 dimer interface [polypeptide binding]; other site 690566009481 phosphorylation site [posttranslational modification] 690566009482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566009483 ATP binding site [chemical binding]; other site 690566009484 Mg2+ binding site [ion binding]; other site 690566009485 G-X-G motif; other site 690566009486 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566009487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009488 active site 690566009489 phosphorylation site [posttranslational modification] 690566009490 intermolecular recognition site; other site 690566009491 dimerization interface [polypeptide binding]; other site 690566009492 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566009493 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009494 Transposase; Region: HTH_Tnp_1; pfam01527 690566009495 HTH-like domain; Region: HTH_21; pfam13276 690566009496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 690566009497 Integrase core domain; Region: rve; pfam00665 690566009498 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 690566009499 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 690566009500 D-pathway; other site 690566009501 Low-spin heme binding site [chemical binding]; other site 690566009502 Putative water exit pathway; other site 690566009503 Binuclear center (active site) [active] 690566009504 K-pathway; other site 690566009505 Putative proton exit pathway; other site 690566009506 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 690566009507 Subunit I/III interface [polypeptide binding]; other site 690566009508 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 690566009509 Cytochrome c; Region: Cytochrom_C; pfam00034 690566009510 cyanophycin synthetase; Provisional; Region: PRK14016 690566009511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 690566009512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 690566009513 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 690566009514 active site 690566009515 dimer interface [polypeptide binding]; other site 690566009516 catalytic nucleophile [active] 690566009517 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 690566009518 proposed catalytic triad [active] 690566009519 active site nucleophile [active] 690566009520 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 690566009521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566009522 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 690566009523 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 690566009524 NADP binding site [chemical binding]; other site 690566009525 active site 690566009526 putative substrate binding site [chemical binding]; other site 690566009527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 690566009528 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 690566009529 putative homodimer interface [polypeptide binding]; other site 690566009530 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 690566009531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 690566009532 UDP-galactopyranose mutase; Region: GLF; pfam03275 690566009533 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 690566009534 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566009535 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 690566009536 FMN binding site [chemical binding]; other site 690566009537 active site 690566009538 substrate binding site [chemical binding]; other site 690566009539 catalytic residue [active] 690566009540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009542 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566009543 [2Fe-2S] cluster binding site [ion binding]; other site 690566009544 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 690566009545 beta subunit interface [polypeptide binding]; other site 690566009546 alpha subunit interface [polypeptide binding]; other site 690566009547 active site 690566009548 substrate binding site [chemical binding]; other site 690566009549 Fe binding site [ion binding]; other site 690566009550 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 690566009551 inter-subunit interface; other site 690566009552 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 690566009553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009554 NAD(P) binding site [chemical binding]; other site 690566009555 active site 690566009556 feruloyl-CoA synthase; Reviewed; Region: PRK08180 690566009557 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566009558 acyl-activating enzyme (AAE) consensus motif; other site 690566009559 AMP binding site [chemical binding]; other site 690566009560 active site 690566009561 CoA binding site [chemical binding]; other site 690566009562 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 690566009563 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 690566009564 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 690566009565 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 690566009566 active site 690566009567 Fe binding site [ion binding]; other site 690566009568 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 690566009569 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566009570 FMN binding site [chemical binding]; other site 690566009571 substrate binding site [chemical binding]; other site 690566009572 putative catalytic residue [active] 690566009573 Carboxylesterase family; Region: COesterase; pfam00135 690566009574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 690566009575 substrate binding pocket [chemical binding]; other site 690566009576 catalytic triad [active] 690566009577 LysR family transcriptional regulator; Provisional; Region: PRK14997 690566009578 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566009580 dimerization interface [polypeptide binding]; other site 690566009581 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 690566009582 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566009583 E3 interaction surface; other site 690566009584 lipoyl attachment site [posttranslational modification]; other site 690566009585 e3 binding domain; Region: E3_binding; pfam02817 690566009586 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566009587 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 690566009588 TPP-binding site [chemical binding]; other site 690566009589 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 690566009590 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 690566009591 PYR/PP interface [polypeptide binding]; other site 690566009592 dimer interface [polypeptide binding]; other site 690566009593 TPP binding site [chemical binding]; other site 690566009594 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566009595 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566009596 putative DNA binding site [nucleotide binding]; other site 690566009597 putative Zn2+ binding site [ion binding]; other site 690566009598 AsnC family; Region: AsnC_trans_reg; pfam01037 690566009599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009601 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566009602 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 690566009603 putative glutathione S-transferase; Provisional; Region: PRK10357 690566009604 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 690566009605 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 690566009606 dimer interface [polypeptide binding]; other site 690566009607 N-terminal domain interface [polypeptide binding]; other site 690566009608 putative substrate binding pocket (H-site) [chemical binding]; other site 690566009609 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 690566009610 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566009611 tetramer interface [polypeptide binding]; other site 690566009612 TPP-binding site [chemical binding]; other site 690566009613 heterodimer interface [polypeptide binding]; other site 690566009614 phosphorylation loop region [posttranslational modification] 690566009615 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 690566009616 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566009617 alpha subunit interface [polypeptide binding]; other site 690566009618 TPP binding site [chemical binding]; other site 690566009619 heterodimer interface [polypeptide binding]; other site 690566009620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566009621 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 690566009622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566009623 active site 690566009624 metal binding site [ion binding]; metal-binding site 690566009625 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 690566009626 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009627 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566009628 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566009629 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009630 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009631 N-terminal plug; other site 690566009632 ligand-binding site [chemical binding]; other site 690566009633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 690566009634 active site 690566009635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009637 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 690566009638 substrate binding pocket [chemical binding]; other site 690566009639 dimerization interface [polypeptide binding]; other site 690566009640 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 690566009641 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 690566009642 FMN-binding pocket [chemical binding]; other site 690566009643 flavin binding motif; other site 690566009644 phosphate binding motif [ion binding]; other site 690566009645 beta-alpha-beta structure motif; other site 690566009646 NAD binding pocket [chemical binding]; other site 690566009647 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566009648 catalytic loop [active] 690566009649 iron binding site [ion binding]; other site 690566009650 FAD binding domain; Region: FAD_binding_3; pfam01494 690566009651 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566009652 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 690566009653 Prostaglandin dehydrogenases; Region: PGDH; cd05288 690566009654 NAD(P) binding site [chemical binding]; other site 690566009655 substrate binding site [chemical binding]; other site 690566009656 dimer interface [polypeptide binding]; other site 690566009657 Predicted transcriptional regulators [Transcription]; Region: COG1733 690566009658 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 690566009659 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009660 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009661 N-terminal plug; other site 690566009662 ligand-binding site [chemical binding]; other site 690566009663 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009664 classical (c) SDRs; Region: SDR_c; cd05233 690566009665 NAD(P) binding site [chemical binding]; other site 690566009666 active site 690566009667 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 690566009668 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 690566009669 NAD(P) binding site [chemical binding]; other site 690566009670 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566009671 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 690566009672 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009674 NAD(P) binding site [chemical binding]; other site 690566009675 active site 690566009676 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 690566009677 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566009678 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566009679 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 690566009680 tetramerization interface [polypeptide binding]; other site 690566009681 NAD(P) binding site [chemical binding]; other site 690566009682 catalytic residues [active] 690566009683 short chain dehydrogenase; Provisional; Region: PRK08267 690566009684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009685 NAD(P) binding site [chemical binding]; other site 690566009686 active site 690566009687 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566009688 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 690566009689 FMN binding site [chemical binding]; other site 690566009690 active site 690566009691 substrate binding site [chemical binding]; other site 690566009692 catalytic residue [active] 690566009693 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 690566009694 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566009695 MarR family; Region: MarR; pfam01047 690566009696 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 690566009697 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 690566009698 putative catalytic residue [active] 690566009699 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 690566009700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009701 NAD(P) binding site [chemical binding]; other site 690566009702 active site 690566009703 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566009704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566009706 NAD(P) binding site [chemical binding]; other site 690566009707 active site 690566009708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566009709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566009710 putative substrate translocation pore; other site 690566009711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566009712 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 690566009713 active site 690566009714 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009715 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566009716 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 690566009717 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 690566009718 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 690566009719 Glutamate binding site [chemical binding]; other site 690566009720 NAD binding site [chemical binding]; other site 690566009721 catalytic residues [active] 690566009722 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 690566009723 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566009724 putative DNA binding site [nucleotide binding]; other site 690566009725 putative Zn2+ binding site [ion binding]; other site 690566009726 AsnC family; Region: AsnC_trans_reg; pfam01037 690566009727 S-formylglutathione hydrolase; Region: PLN02442 690566009728 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 690566009729 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 690566009730 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 690566009731 substrate binding site [chemical binding]; other site 690566009732 catalytic Zn binding site [ion binding]; other site 690566009733 NAD binding site [chemical binding]; other site 690566009734 structural Zn binding site [ion binding]; other site 690566009735 dimer interface [polypeptide binding]; other site 690566009736 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009738 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566009739 dimerization interface [polypeptide binding]; other site 690566009740 glutathione reductase; Validated; Region: PRK06116 690566009741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566009742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566009743 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 690566009744 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 690566009745 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566009746 dimer interface [polypeptide binding]; other site 690566009747 active site 690566009748 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 690566009749 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 690566009750 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 690566009751 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 690566009752 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566009753 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 690566009754 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 690566009755 active site 690566009756 catalytic residues [active] 690566009757 metal binding site [ion binding]; metal-binding site 690566009758 DmpG-like communication domain; Region: DmpG_comm; pfam07836 690566009759 acetaldehyde dehydrogenase; Validated; Region: PRK08300 690566009760 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 690566009761 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 690566009762 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 690566009763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566009764 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566009765 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 690566009766 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 690566009767 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566009768 active site 690566009769 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566009770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009771 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566009772 NAD(P) binding site [chemical binding]; other site 690566009773 active site 690566009774 EthD domain; Region: EthD; pfam07110 690566009775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009776 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566009777 NAD(P) binding site [chemical binding]; other site 690566009778 active site 690566009779 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 690566009780 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566009781 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566009782 acyl-activating enzyme (AAE) consensus motif; other site 690566009783 acyl-activating enzyme (AAE) consensus motif; other site 690566009784 putative AMP binding site [chemical binding]; other site 690566009785 putative active site [active] 690566009786 putative CoA binding site [chemical binding]; other site 690566009787 enoyl-CoA hydratase; Provisional; Region: PRK08140 690566009788 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566009789 substrate binding site [chemical binding]; other site 690566009790 oxyanion hole (OAH) forming residues; other site 690566009791 trimer interface [polypeptide binding]; other site 690566009792 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 690566009793 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 690566009794 dimer interface [polypeptide binding]; other site 690566009795 active site 690566009796 heme binding site [chemical binding]; other site 690566009797 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 690566009798 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 690566009799 putative deacylase active site [active] 690566009800 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 690566009801 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566009802 dimer interface [polypeptide binding]; other site 690566009803 active site 690566009804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009806 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 690566009807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009808 NAD(P) binding site [chemical binding]; other site 690566009809 active site 690566009810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566009811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566009812 active site 690566009813 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 690566009814 Phosphotransferase enzyme family; Region: APH; pfam01636 690566009815 putative active site [active] 690566009816 putative substrate binding site [chemical binding]; other site 690566009817 ATP binding site [chemical binding]; other site 690566009818 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960 690566009819 NodB motif; other site 690566009820 putative active site [active] 690566009821 putative catalytic site [active] 690566009822 putative Zn binding site [ion binding]; other site 690566009823 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 690566009824 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 690566009825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009829 enterobactin exporter EntS; Provisional; Region: PRK10489 690566009830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566009831 putative substrate translocation pore; other site 690566009832 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 690566009833 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 690566009834 dimer interface [polypeptide binding]; other site 690566009835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566009836 catalytic residue [active] 690566009837 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 690566009838 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 690566009839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566009840 dimer interface [polypeptide binding]; other site 690566009841 phosphorylation site [posttranslational modification] 690566009842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566009843 ATP binding site [chemical binding]; other site 690566009844 Mg2+ binding site [ion binding]; other site 690566009845 G-X-G motif; other site 690566009846 Response regulator receiver domain; Region: Response_reg; pfam00072 690566009847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009848 active site 690566009849 phosphorylation site [posttranslational modification] 690566009850 intermolecular recognition site; other site 690566009851 dimerization interface [polypeptide binding]; other site 690566009852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 690566009853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009854 active site 690566009855 phosphorylation site [posttranslational modification] 690566009856 intermolecular recognition site; other site 690566009857 dimerization interface [polypeptide binding]; other site 690566009858 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 690566009859 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 690566009860 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 690566009861 NAD(P) binding site [chemical binding]; other site 690566009862 CHASE domain; Region: CHASE; pfam03924 690566009863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566009864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566009865 dimer interface [polypeptide binding]; other site 690566009866 phosphorylation site [posttranslational modification] 690566009867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566009868 ATP binding site [chemical binding]; other site 690566009869 Mg2+ binding site [ion binding]; other site 690566009870 G-X-G motif; other site 690566009871 Response regulator receiver domain; Region: Response_reg; pfam00072 690566009872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009873 active site 690566009874 phosphorylation site [posttranslational modification] 690566009875 intermolecular recognition site; other site 690566009876 dimerization interface [polypeptide binding]; other site 690566009877 Response regulator receiver domain; Region: Response_reg; pfam00072 690566009878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566009879 active site 690566009880 phosphorylation site [posttranslational modification] 690566009881 intermolecular recognition site; other site 690566009882 dimerization interface [polypeptide binding]; other site 690566009883 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 690566009884 Sel1-like repeats; Region: SEL1; smart00671 690566009885 Sel1-like repeats; Region: SEL1; smart00671 690566009886 Sel1-like repeats; Region: SEL1; smart00671 690566009887 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 690566009888 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 690566009889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 690566009892 dimerization interface [polypeptide binding]; other site 690566009893 Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779 690566009894 acyl-CoA synthetase; Validated; Region: PRK05850 690566009895 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 690566009896 acyl-activating enzyme (AAE) consensus motif; other site 690566009897 active site 690566009898 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 690566009899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 690566009900 S-adenosylmethionine binding site [chemical binding]; other site 690566009901 Autoinducer synthetase; Region: Autoind_synth; cl17404 690566009902 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009903 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009904 N-terminal plug; other site 690566009905 ligand-binding site [chemical binding]; other site 690566009906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566009907 PAS fold; Region: PAS_3; pfam08447 690566009908 putative active site [active] 690566009909 heme pocket [chemical binding]; other site 690566009910 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 690566009911 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 690566009912 metal binding site [ion binding]; metal-binding site 690566009913 active site 690566009914 I-site; other site 690566009915 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 690566009916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566009917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566009918 putative substrate translocation pore; other site 690566009919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566009920 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 690566009921 NAD(P) binding site [chemical binding]; other site 690566009922 active site 690566009923 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 690566009924 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 690566009925 active site 690566009926 Zn binding site [ion binding]; other site 690566009927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 690566009928 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 690566009929 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 690566009930 substrate binding pocket [chemical binding]; other site 690566009931 membrane-bound complex binding site; other site 690566009932 hinge residues; other site 690566009933 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566009934 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 690566009935 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566009936 active site 690566009937 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 690566009938 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 690566009939 NAD binding site [chemical binding]; other site 690566009940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009942 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566009943 dimerization interface [polypeptide binding]; other site 690566009944 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 690566009945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 690566009946 dimer interface [polypeptide binding]; other site 690566009947 conserved gate region; other site 690566009948 ABC-ATPase subunit interface; other site 690566009949 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 690566009950 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 690566009951 Walker A/P-loop; other site 690566009952 ATP binding site [chemical binding]; other site 690566009953 Q-loop/lid; other site 690566009954 ABC transporter signature motif; other site 690566009955 Walker B; other site 690566009956 D-loop; other site 690566009957 H-loop/switch region; other site 690566009958 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 690566009959 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 690566009960 active site residue [active] 690566009961 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 690566009962 active site residue [active] 690566009963 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 690566009964 active site residue [active] 690566009965 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 690566009966 active site 690566009967 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 690566009968 dimer interface [polypeptide binding]; other site 690566009969 non-prolyl cis peptide bond; other site 690566009970 insertion regions; other site 690566009971 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 690566009972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 690566009973 membrane-bound complex binding site; other site 690566009974 aldolase II superfamily protein; Provisional; Region: PRK07044 690566009975 intersubunit interface [polypeptide binding]; other site 690566009976 active site 690566009977 Zn2+ binding site [ion binding]; other site 690566009978 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566009979 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566009980 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009981 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566009982 N-terminal plug; other site 690566009983 ligand-binding site [chemical binding]; other site 690566009984 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566009985 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 690566009986 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566009987 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 690566009988 active site 690566009989 FMN binding site [chemical binding]; other site 690566009990 substrate binding site [chemical binding]; other site 690566009991 putative catalytic residue [active] 690566009992 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 690566009993 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566009994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566009995 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 690566009996 putative effector binding pocket; other site 690566009997 dimerization interface [polypeptide binding]; other site 690566009998 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566009999 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566010000 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 690566010001 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 690566010002 conserved cys residue [active] 690566010003 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010004 classical (c) SDRs; Region: SDR_c; cd05233 690566010005 NAD(P) binding site [chemical binding]; other site 690566010006 active site 690566010007 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 690566010008 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010009 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010010 N-terminal plug; other site 690566010011 ligand-binding site [chemical binding]; other site 690566010012 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 690566010013 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 690566010014 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 690566010015 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566010016 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 690566010017 Ecdysteroid kinase; Region: EcKinase; cl17738 690566010018 Phosphotransferase enzyme family; Region: APH; pfam01636 690566010019 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010021 NAD(P) binding site [chemical binding]; other site 690566010022 active site 690566010023 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 690566010024 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 690566010025 putative NAD(P) binding site [chemical binding]; other site 690566010026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010027 NAD(P) binding site [chemical binding]; other site 690566010028 active site 690566010029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010031 EthD domain; Region: EthD; cl17553 690566010032 short chain dehydrogenase; Provisional; Region: PRK06125 690566010033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010034 NAD(P) binding site [chemical binding]; other site 690566010035 active site 690566010036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010037 short chain dehydrogenase; Provisional; Region: PRK07791 690566010038 NAD(P) binding site [chemical binding]; other site 690566010039 active site 690566010040 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566010041 MarR family; Region: MarR; pfam01047 690566010042 MarR family; Region: MarR_2; cl17246 690566010043 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566010044 Cytochrome P450; Region: p450; cl12078 690566010045 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 690566010046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566010047 catalytic loop [active] 690566010048 iron binding site [ion binding]; other site 690566010049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566010050 Cytochrome P450; Region: p450; cl12078 690566010051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010053 choline dehydrogenase; Validated; Region: PRK02106 690566010054 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566010055 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 690566010056 Beta-lactamase; Region: Beta-lactamase; pfam00144 690566010057 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566010058 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010059 substrate binding site [chemical binding]; other site 690566010060 oxyanion hole (OAH) forming residues; other site 690566010061 trimer interface [polypeptide binding]; other site 690566010062 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 690566010063 active site 690566010064 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566010065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566010066 DNA-binding site [nucleotide binding]; DNA binding site 690566010067 FCD domain; Region: FCD; pfam07729 690566010068 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 690566010069 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010070 NAD(P) binding site [chemical binding]; other site 690566010071 active site 690566010072 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010073 classical (c) SDRs; Region: SDR_c; cd05233 690566010074 NAD(P) binding site [chemical binding]; other site 690566010075 active site 690566010076 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 690566010077 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566010078 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010079 acyl-activating enzyme (AAE) consensus motif; other site 690566010080 putative AMP binding site [chemical binding]; other site 690566010081 putative active site [active] 690566010082 putative CoA binding site [chemical binding]; other site 690566010083 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010084 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010085 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 690566010086 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 690566010087 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566010088 catalytic loop [active] 690566010089 iron binding site [ion binding]; other site 690566010090 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 690566010091 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 690566010092 putative NAD(P) binding site [chemical binding]; other site 690566010093 catalytic Zn binding site [ion binding]; other site 690566010094 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 690566010095 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010096 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010097 enoyl-CoA hydratase; Provisional; Region: PRK08140 690566010098 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010099 substrate binding site [chemical binding]; other site 690566010100 oxyanion hole (OAH) forming residues; other site 690566010101 trimer interface [polypeptide binding]; other site 690566010102 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 690566010103 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 690566010104 phosphate binding site [ion binding]; other site 690566010105 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566010106 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010107 classical (c) SDRs; Region: SDR_c; cd05233 690566010108 NAD(P) binding site [chemical binding]; other site 690566010109 active site 690566010110 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 690566010111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 690566010112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010114 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 690566010115 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 690566010116 active site 690566010117 putative substrate binding pocket [chemical binding]; other site 690566010118 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566010119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010122 NAD(P) binding site [chemical binding]; other site 690566010123 active site 690566010124 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 690566010125 acyl-CoA thioesterase II; Region: tesB; TIGR00189 690566010126 active site 690566010127 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 690566010128 catalytic triad [active] 690566010129 dimer interface [polypeptide binding]; other site 690566010130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566010132 putative substrate translocation pore; other site 690566010133 enoyl-CoA hydratase; Provisional; Region: PRK05864 690566010134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010135 substrate binding site [chemical binding]; other site 690566010136 oxyanion hole (OAH) forming residues; other site 690566010137 trimer interface [polypeptide binding]; other site 690566010138 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566010139 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 690566010140 Amidohydrolase; Region: Amidohydro_2; pfam04909 690566010141 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010142 substrate binding site [chemical binding]; other site 690566010143 oxyanion hole (OAH) forming residues; other site 690566010144 trimer interface [polypeptide binding]; other site 690566010145 Epoxide hydrolase N terminus; Region: EHN; pfam06441 690566010146 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 690566010147 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 690566010148 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 690566010149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010150 NmrA-like family; Region: NmrA; pfam05368 690566010151 NAD(P) binding site [chemical binding]; other site 690566010152 active site 690566010153 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 690566010154 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010155 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566010156 acyl-activating enzyme (AAE) consensus motif; other site 690566010157 acyl-activating enzyme (AAE) consensus motif; other site 690566010158 putative AMP binding site [chemical binding]; other site 690566010159 putative active site [active] 690566010160 putative CoA binding site [chemical binding]; other site 690566010161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010162 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566010163 putative substrate translocation pore; other site 690566010164 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 690566010165 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566010166 NAD binding site [chemical binding]; other site 690566010167 catalytic residues [active] 690566010168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010170 NAD(P) binding site [chemical binding]; other site 690566010171 active site 690566010172 choline dehydrogenase; Validated; Region: PRK02106 690566010173 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566010174 short chain dehydrogenase; Validated; Region: PRK08264 690566010175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010176 NAD(P) binding site [chemical binding]; other site 690566010177 active site 690566010178 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566010179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010180 active site 690566010181 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566010182 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 690566010183 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566010184 active site 690566010185 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566010186 MarR family; Region: MarR_2; cl17246 690566010187 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010188 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566010189 Ecdysteroid kinase; Region: EcKinase; cl17738 690566010190 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 690566010191 active site 690566010192 metal binding site [ion binding]; metal-binding site 690566010193 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 690566010194 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010195 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566010196 acyl-activating enzyme (AAE) consensus motif; other site 690566010197 putative AMP binding site [chemical binding]; other site 690566010198 putative active site [active] 690566010199 putative CoA binding site [chemical binding]; other site 690566010200 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 690566010201 Amidohydrolase; Region: Amidohydro_2; pfam04909 690566010202 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566010203 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 690566010204 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566010205 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 690566010206 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566010207 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 690566010208 2-enoyl thioester reductase (ETR); Region: ETR; cd08290 690566010209 NADP binding site [chemical binding]; other site 690566010210 dimer interface [polypeptide binding]; other site 690566010211 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566010212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010213 active site 690566010214 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566010215 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566010216 active site 690566010217 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 690566010218 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 690566010219 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566010220 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566010221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010222 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566010223 substrate binding site [chemical binding]; other site 690566010224 oxyanion hole (OAH) forming residues; other site 690566010225 trimer interface [polypeptide binding]; other site 690566010226 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010227 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 690566010228 substrate binding site [chemical binding]; other site 690566010229 oxyanion hole (OAH) forming residues; other site 690566010230 trimer interface [polypeptide binding]; other site 690566010231 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 690566010232 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566010233 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 690566010234 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566010235 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010236 active site 690566010237 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566010238 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566010239 [2Fe-2S] cluster binding site [ion binding]; other site 690566010240 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 690566010241 putative alpha subunit interface [polypeptide binding]; other site 690566010242 putative active site [active] 690566010243 putative substrate binding site [chemical binding]; other site 690566010244 Fe binding site [ion binding]; other site 690566010245 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 690566010246 Predicted oxidoreductase [General function prediction only]; Region: COG3573 690566010247 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 690566010248 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 690566010249 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 690566010250 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 690566010251 conserved cys residue [active] 690566010252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566010253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566010254 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010255 classical (c) SDRs; Region: SDR_c; cd05233 690566010256 NAD(P) binding site [chemical binding]; other site 690566010257 active site 690566010258 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566010259 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566010260 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 690566010261 EamA-like transporter family; Region: EamA; cl17759 690566010262 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 690566010263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010264 NAD(P) binding site [chemical binding]; other site 690566010265 active site 690566010266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 690566010268 NAD(P) binding site [chemical binding]; other site 690566010269 active site 690566010270 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566010271 classical (c) SDRs; Region: SDR_c; cd05233 690566010272 NAD(P) binding site [chemical binding]; other site 690566010273 active site 690566010274 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566010275 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566010276 [2Fe-2S] cluster binding site [ion binding]; other site 690566010277 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 690566010278 putative alpha subunit interface [polypeptide binding]; other site 690566010279 putative active site [active] 690566010280 putative substrate binding site [chemical binding]; other site 690566010281 Fe binding site [ion binding]; other site 690566010282 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566010283 classical (c) SDRs; Region: SDR_c; cd05233 690566010284 NAD(P) binding site [chemical binding]; other site 690566010285 active site 690566010286 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566010287 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010288 substrate binding site [chemical binding]; other site 690566010289 oxyanion hole (OAH) forming residues; other site 690566010290 trimer interface [polypeptide binding]; other site 690566010291 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 690566010292 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566010293 tetramer interface [polypeptide binding]; other site 690566010294 TPP-binding site [chemical binding]; other site 690566010295 heterodimer interface [polypeptide binding]; other site 690566010296 phosphorylation loop region [posttranslational modification] 690566010297 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 690566010298 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566010299 alpha subunit interface [polypeptide binding]; other site 690566010300 TPP binding site [chemical binding]; other site 690566010301 heterodimer interface [polypeptide binding]; other site 690566010302 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566010303 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566010304 E3 interaction surface; other site 690566010305 lipoyl attachment site [posttranslational modification]; other site 690566010306 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 690566010307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010308 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 690566010309 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010310 acyl-activating enzyme (AAE) consensus motif; other site 690566010311 acyl-activating enzyme (AAE) consensus motif; other site 690566010312 putative AMP binding site [chemical binding]; other site 690566010313 putative active site [active] 690566010314 putative CoA binding site [chemical binding]; other site 690566010315 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566010316 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 690566010317 C-terminal domain interface [polypeptide binding]; other site 690566010318 GSH binding site (G-site) [chemical binding]; other site 690566010319 dimer interface [polypeptide binding]; other site 690566010320 classical (c) SDRs; Region: SDR_c; cd05233 690566010321 NAD(P) binding site [chemical binding]; other site 690566010322 active site 690566010323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566010324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566010325 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 690566010326 putative effector binding pocket; other site 690566010327 dimerization interface [polypeptide binding]; other site 690566010328 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566010329 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 690566010330 active site 690566010331 iron coordination sites [ion binding]; other site 690566010332 substrate binding pocket [chemical binding]; other site 690566010333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010335 thiolase; Provisional; Region: PRK06158 690566010336 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566010337 active site 690566010338 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 690566010339 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566010340 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566010341 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010342 substrate binding site [chemical binding]; other site 690566010343 oxyanion hole (OAH) forming residues; other site 690566010344 trimer interface [polypeptide binding]; other site 690566010345 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 690566010346 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566010347 dimer interface [polypeptide binding]; other site 690566010348 active site 690566010349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010350 short chain dehydrogenase; Provisional; Region: PRK12828 690566010351 NAD(P) binding site [chemical binding]; other site 690566010352 active site 690566010353 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 690566010354 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 690566010355 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 690566010356 active site 690566010357 putative substrate binding pocket [chemical binding]; other site 690566010358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566010359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566010361 putative substrate translocation pore; other site 690566010362 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566010363 Cytochrome P450; Region: p450; cl12078 690566010364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010365 classical (c) SDRs; Region: SDR_c; cd05233 690566010366 NAD(P) binding site [chemical binding]; other site 690566010367 active site 690566010368 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 690566010369 active site 690566010370 non-prolyl cis peptide bond; other site 690566010371 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 690566010372 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 690566010373 active site 690566010374 non-prolyl cis peptide bond; other site 690566010375 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 690566010376 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566010377 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010378 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010379 N-terminal plug; other site 690566010380 ligand-binding site [chemical binding]; other site 690566010381 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010383 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 690566010384 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 690566010385 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 690566010386 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 690566010387 MgtC family; Region: MgtC; pfam02308 690566010388 OsmC-like protein; Region: OsmC; pfam02566 690566010389 Pirin-related protein [General function prediction only]; Region: COG1741 690566010390 Pirin; Region: Pirin; pfam02678 690566010391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566010392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566010393 LysR substrate binding domain; Region: LysR_substrate; pfam03466 690566010394 dimerization interface [polypeptide binding]; other site 690566010395 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 690566010396 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 690566010397 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 690566010398 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 690566010399 DoxX; Region: DoxX; pfam07681 690566010400 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 690566010401 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 690566010402 active site 690566010403 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 690566010404 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 690566010405 catalytic triad [active] 690566010406 dimer interface [polypeptide binding]; other site 690566010407 Isochorismatase family; Region: Isochorismatase; pfam00857 690566010408 conserved cis-peptide bond; other site 690566010409 Transposase; Region: HTH_Tnp_1; pfam01527 690566010410 HTH-like domain; Region: HTH_21; pfam13276 690566010411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 690566010412 Integrase core domain; Region: rve; pfam00665 690566010413 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 690566010414 WHG domain; Region: WHG; pfam13305 690566010415 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 690566010416 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 690566010417 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566010418 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566010419 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566010420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566010423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566010424 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 690566010425 dimerization interface [polypeptide binding]; other site 690566010426 Transcriptional regulators [Transcription]; Region: MarR; COG1846 690566010427 MarR family; Region: MarR_2; pfam12802 690566010428 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 690566010429 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 690566010430 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 690566010431 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566010432 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 690566010433 maleylacetoacetate isomerase; Region: maiA; TIGR01262 690566010434 C-terminal domain interface [polypeptide binding]; other site 690566010435 GSH binding site (G-site) [chemical binding]; other site 690566010436 putative dimer interface [polypeptide binding]; other site 690566010437 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 690566010438 dimer interface [polypeptide binding]; other site 690566010439 N-terminal domain interface [polypeptide binding]; other site 690566010440 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 690566010441 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 690566010442 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 690566010443 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 690566010444 putative dimer interface [polypeptide binding]; other site 690566010445 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 690566010446 SLBB domain; Region: SLBB; pfam10531 690566010447 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 690566010448 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 690566010449 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566010450 catalytic loop [active] 690566010451 iron binding site [ion binding]; other site 690566010452 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 690566010453 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 690566010454 [4Fe-4S] binding site [ion binding]; other site 690566010455 molybdopterin cofactor binding site; other site 690566010456 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 690566010457 molybdopterin cofactor binding site; other site 690566010458 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 690566010459 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 690566010460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010463 putative substrate translocation pore; other site 690566010464 Porin subfamily; Region: Porin_2; pfam02530 690566010465 acetyl-CoA synthetase; Provisional; Region: PRK00174 690566010466 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 690566010467 active site 690566010468 CoA binding site [chemical binding]; other site 690566010469 acyl-activating enzyme (AAE) consensus motif; other site 690566010470 AMP binding site [chemical binding]; other site 690566010471 acetate binding site [chemical binding]; other site 690566010472 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566010473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566010474 active site 690566010475 phosphorylation site [posttranslational modification] 690566010476 intermolecular recognition site; other site 690566010477 dimerization interface [polypeptide binding]; other site 690566010478 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566010479 DNA binding residues [nucleotide binding] 690566010480 dimerization interface [polypeptide binding]; other site 690566010481 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 690566010482 PAS fold; Region: PAS_7; pfam12860 690566010483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566010484 putative active site [active] 690566010485 heme pocket [chemical binding]; other site 690566010486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566010487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566010488 dimer interface [polypeptide binding]; other site 690566010489 phosphorylation site [posttranslational modification] 690566010490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566010491 ATP binding site [chemical binding]; other site 690566010492 Mg2+ binding site [ion binding]; other site 690566010493 G-X-G motif; other site 690566010494 Response regulator receiver domain; Region: Response_reg; pfam00072 690566010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566010496 active site 690566010497 phosphorylation site [posttranslational modification] 690566010498 intermolecular recognition site; other site 690566010499 dimerization interface [polypeptide binding]; other site 690566010500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566010501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566010502 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 690566010503 dimerization interface [polypeptide binding]; other site 690566010504 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 690566010505 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566010506 tetramer interface [polypeptide binding]; other site 690566010507 TPP-binding site [chemical binding]; other site 690566010508 heterodimer interface [polypeptide binding]; other site 690566010509 phosphorylation loop region [posttranslational modification] 690566010510 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 690566010511 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 690566010512 E3 interaction surface; other site 690566010513 lipoyl attachment site [posttranslational modification]; other site 690566010514 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566010515 alpha subunit interface [polypeptide binding]; other site 690566010516 TPP binding site [chemical binding]; other site 690566010517 heterodimer interface [polypeptide binding]; other site 690566010518 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566010519 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 690566010520 MarR family; Region: MarR_2; pfam12802 690566010521 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566010522 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 690566010523 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 690566010524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 690566010525 membrane-bound complex binding site; other site 690566010526 hinge residues; other site 690566010527 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010528 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010529 N-terminal plug; other site 690566010530 ligand-binding site [chemical binding]; other site 690566010531 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 690566010532 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 690566010533 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 690566010534 putative dimer interface [polypeptide binding]; other site 690566010535 active site pocket [active] 690566010536 putative cataytic base [active] 690566010537 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 690566010538 catalytic core [active] 690566010539 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 690566010540 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 690566010541 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 690566010542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 690566010543 homodimer interface [polypeptide binding]; other site 690566010544 catalytic residue [active] 690566010545 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 690566010546 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 690566010547 homotrimer interface [polypeptide binding]; other site 690566010548 Walker A motif; other site 690566010549 GTP binding site [chemical binding]; other site 690566010550 Walker B motif; other site 690566010551 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566010552 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 690566010553 Protein export membrane protein; Region: SecD_SecF; cl14618 690566010554 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 690566010555 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566010556 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566010557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566010558 active site 690566010559 phosphorylation site [posttranslational modification] 690566010560 intermolecular recognition site; other site 690566010561 dimerization interface [polypeptide binding]; other site 690566010562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 690566010563 DNA binding site [nucleotide binding] 690566010564 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 690566010565 dimerization interface [polypeptide binding]; other site 690566010566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566010567 ATP binding site [chemical binding]; other site 690566010568 Mg2+ binding site [ion binding]; other site 690566010569 G-X-G motif; other site 690566010570 PrkA family serine protein kinase; Provisional; Region: PRK15455 690566010571 AAA ATPase domain; Region: AAA_16; pfam13191 690566010572 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 690566010573 hypothetical protein; Provisional; Region: PRK05325 690566010574 SpoVR family protein; Provisional; Region: PRK11767 690566010575 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 690566010576 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 690566010577 active site 690566010578 SAM binding site [chemical binding]; other site 690566010579 homodimer interface [polypeptide binding]; other site 690566010580 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 690566010581 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 690566010582 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 690566010583 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 690566010584 active site 690566010585 SAM binding site [chemical binding]; other site 690566010586 homodimer interface [polypeptide binding]; other site 690566010587 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 690566010588 active site 690566010589 putative homodimer interface [polypeptide binding]; other site 690566010590 SAM binding site [chemical binding]; other site 690566010591 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 690566010592 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 690566010593 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 690566010594 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 690566010595 active site 690566010596 SAM binding site [chemical binding]; other site 690566010597 homodimer interface [polypeptide binding]; other site 690566010598 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 690566010599 active site 690566010600 SAM binding site [chemical binding]; other site 690566010601 homodimer interface [polypeptide binding]; other site 690566010602 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 690566010603 Precorrin-8X methylmutase; Region: CbiC; pfam02570 690566010604 precorrin-3B synthase; Region: CobG; TIGR02435 690566010605 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 690566010606 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 690566010607 FMN binding site [chemical binding]; other site 690566010608 dimer interface [polypeptide binding]; other site 690566010609 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 690566010610 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 690566010611 homodimer interface [polypeptide binding]; other site 690566010612 Walker A motif; other site 690566010613 ATP binding site [chemical binding]; other site 690566010614 hydroxycobalamin binding site [chemical binding]; other site 690566010615 Walker B motif; other site 690566010616 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 690566010617 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 690566010618 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 690566010619 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 690566010620 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 690566010621 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 690566010622 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 690566010623 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 690566010624 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010625 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010626 N-terminal plug; other site 690566010627 ligand-binding site [chemical binding]; other site 690566010628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 690566010629 CHAT domain; Region: CHAT; pfam12770 690566010630 CHASE2 domain; Region: CHASE2; pfam05226 690566010631 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 690566010632 cyclase homology domain; Region: CHD; cd07302 690566010633 nucleotidyl binding site; other site 690566010634 metal binding site [ion binding]; metal-binding site 690566010635 dimer interface [polypeptide binding]; other site 690566010636 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 690566010637 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 690566010638 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 690566010639 Domain of unknown function (DUF336); Region: DUF336; cl01249 690566010640 Domain of unknown function (DUF336); Region: DUF336; cl01249 690566010641 LVIVD repeat; Region: LVIVD; pfam08309 690566010642 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 690566010643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 690566010644 active site 690566010645 metal binding site [ion binding]; metal-binding site 690566010646 hexamer interface [polypeptide binding]; other site 690566010647 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566010648 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 690566010649 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566010650 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566010651 ligand binding site [chemical binding]; other site 690566010652 flexible hinge region; other site 690566010653 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 690566010654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 690566010655 ligand binding site [chemical binding]; other site 690566010656 flexible hinge region; other site 690566010657 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 690566010658 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 690566010659 4Fe-4S binding domain; Region: Fer4; pfam00037 690566010660 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 690566010661 TPR repeat; Region: TPR_11; pfam13414 690566010662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 690566010663 binding surface 690566010664 TPR motif; other site 690566010665 Helix-turn-helix domain; Region: HTH_28; pfam13518 690566010666 Winged helix-turn helix; Region: HTH_29; pfam13551 690566010667 Homeodomain-like domain; Region: HTH_32; pfam13565 690566010668 Integrase core domain; Region: rve; pfam00665 690566010669 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010670 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566010671 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566010672 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 690566010673 active site 690566010674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 690566010676 putative substrate translocation pore; other site 690566010677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010678 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 690566010679 NAD(P) binding site [chemical binding]; other site 690566010680 active site 690566010681 SnoaL-like domain; Region: SnoaL_4; pfam13577 690566010682 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 690566010683 MarR family; Region: MarR_2; cl17246 690566010684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010686 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 690566010687 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 690566010688 catalytic Zn binding site [ion binding]; other site 690566010689 NAD binding site [chemical binding]; other site 690566010690 structural Zn binding site [ion binding]; other site 690566010691 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566010692 Cytochrome P450; Region: p450; cl12078 690566010693 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 690566010694 active site 690566010695 catalytic site [active] 690566010696 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 690566010697 active site 2 [active] 690566010698 active site 1 [active] 690566010699 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010700 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010701 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010702 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010703 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566010704 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 690566010705 NAD(P) binding site [chemical binding]; other site 690566010706 catalytic residues [active] 690566010707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010708 NAD(P) binding site [chemical binding]; other site 690566010709 active site 690566010710 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 690566010711 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566010712 thiolase; Provisional; Region: PRK06158 690566010713 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566010714 active site 690566010715 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010717 N-terminal plug; other site 690566010718 ligand-binding site [chemical binding]; other site 690566010719 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 690566010720 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 690566010721 FMN binding site [chemical binding]; other site 690566010722 substrate binding site [chemical binding]; other site 690566010723 putative catalytic residue [active] 690566010724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010725 WHG domain; Region: WHG; pfam13305 690566010726 EthD domain; Region: EthD; pfam07110 690566010727 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 690566010728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 690566010729 MltA-interacting protein MipA; Region: MipA; cl01504 690566010730 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 690566010731 LytTr DNA-binding domain; Region: LytTR; pfam04397 690566010732 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566010733 active site 690566010734 metal binding site [ion binding]; metal-binding site 690566010735 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566010736 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010737 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010738 N-terminal plug; other site 690566010739 ligand-binding site [chemical binding]; other site 690566010740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010742 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566010743 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010744 N-terminal plug; other site 690566010745 ligand-binding site [chemical binding]; other site 690566010746 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 690566010747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010748 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010749 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 690566010750 Phosphotransferase enzyme family; Region: APH; pfam01636 690566010751 putative active site [active] 690566010752 putative substrate binding site [chemical binding]; other site 690566010753 ATP binding site [chemical binding]; other site 690566010754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566010755 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010756 active site 690566010757 short chain dehydrogenase; Provisional; Region: PRK06949 690566010758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010759 NAD(P) binding site [chemical binding]; other site 690566010760 active site 690566010761 short chain dehydrogenase; Provisional; Region: PRK07791 690566010762 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010763 NAD(P) binding site [chemical binding]; other site 690566010764 active site 690566010765 enoyl-CoA hydratase; Provisional; Region: PRK08260 690566010766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566010767 substrate binding site [chemical binding]; other site 690566010768 oxyanion hole (OAH) forming residues; other site 690566010769 trimer interface [polypeptide binding]; other site 690566010770 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566010771 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010772 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010773 acyl-activating enzyme (AAE) consensus motif; other site 690566010774 putative AMP binding site [chemical binding]; other site 690566010775 putative active site [active] 690566010776 acyl-activating enzyme (AAE) consensus motif; other site 690566010777 putative CoA binding site [chemical binding]; other site 690566010778 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010779 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010780 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 690566010781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010782 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010783 acyl-activating enzyme (AAE) consensus motif; other site 690566010784 putative AMP binding site [chemical binding]; other site 690566010785 putative active site [active] 690566010786 putative CoA binding site [chemical binding]; other site 690566010787 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566010788 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010789 active site 690566010790 acetyl-CoA acetyltransferase; Validated; Region: PRK06157 690566010791 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566010792 active site 690566010793 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 690566010794 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 690566010795 dimer interface [polypeptide binding]; other site 690566010796 active site 690566010797 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 690566010798 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566010799 enoyl-CoA hydratase; Region: PLN02864 690566010800 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 690566010801 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 690566010802 dimer interaction site [polypeptide binding]; other site 690566010803 substrate-binding tunnel; other site 690566010804 active site 690566010805 catalytic site [active] 690566010806 substrate binding site [chemical binding]; other site 690566010807 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 690566010808 Transcriptional regulator [Transcription]; Region: IclR; COG1414 690566010809 Bacterial transcriptional regulator; Region: IclR; pfam01614 690566010810 acetyl-CoA acetyltransferase; Provisional; Region: PRK06025 690566010811 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566010812 dimer interface [polypeptide binding]; other site 690566010813 active site 690566010814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010815 short chain dehydrogenase; Validated; Region: PRK07069 690566010816 NAD(P) binding site [chemical binding]; other site 690566010817 active site 690566010818 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 690566010819 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 690566010820 molybdopterin cofactor binding site; other site 690566010821 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 690566010822 molybdopterin cofactor binding site; other site 690566010823 GXWXG protein; Region: GXWXG; pfam14231 690566010824 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 690566010825 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 690566010826 putative hydrophobic ligand binding site [chemical binding]; other site 690566010827 protein interface [polypeptide binding]; other site 690566010828 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566010829 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010830 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010831 acyl-activating enzyme (AAE) consensus motif; other site 690566010832 putative AMP binding site [chemical binding]; other site 690566010833 putative active site [active] 690566010834 putative CoA binding site [chemical binding]; other site 690566010835 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 690566010836 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 690566010837 NAD binding site [chemical binding]; other site 690566010838 catalytic Zn binding site [ion binding]; other site 690566010839 substrate binding site [chemical binding]; other site 690566010840 structural Zn binding site [ion binding]; other site 690566010841 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 690566010842 active site 690566010843 metal binding site [ion binding]; metal-binding site 690566010844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 690566010845 long-chain-fatty-acid--CoA ligase; Provisional; Region: PRK12406 690566010846 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010847 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010848 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010849 acyl-activating enzyme (AAE) consensus motif; other site 690566010850 putative AMP binding site [chemical binding]; other site 690566010851 putative active site [active] 690566010852 acyl-activating enzyme (AAE) consensus motif; other site 690566010853 putative CoA binding site [chemical binding]; other site 690566010854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010855 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566010856 active site 690566010857 metal binding site [ion binding]; metal-binding site 690566010858 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566010859 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010860 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010861 N-terminal plug; other site 690566010862 ligand-binding site [chemical binding]; other site 690566010863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010864 D-galactonate transporter; Region: 2A0114; TIGR00893 690566010865 putative substrate translocation pore; other site 690566010866 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566010867 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 690566010868 NAD(P) binding site [chemical binding]; other site 690566010869 catalytic residues [active] 690566010870 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 690566010871 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 690566010872 catalytic Zn binding site [ion binding]; other site 690566010873 NAD binding site [chemical binding]; other site 690566010874 structural Zn binding site [ion binding]; other site 690566010875 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566010876 AMP-binding domain protein; Validated; Region: PRK08315 690566010877 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010878 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 690566010879 acyl-activating enzyme (AAE) consensus motif; other site 690566010880 putative AMP binding site [chemical binding]; other site 690566010881 putative active site [active] 690566010882 putative CoA binding site [chemical binding]; other site 690566010883 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 690566010884 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 690566010885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010886 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010887 NAD(P) binding site [chemical binding]; other site 690566010888 active site 690566010889 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566010890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 690566010891 GXWXG protein; Region: GXWXG; pfam14231 690566010892 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 690566010893 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566010894 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010895 N-terminal plug; other site 690566010896 ligand-binding site [chemical binding]; other site 690566010897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 690566010898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566010899 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 690566010900 NAD(P) binding site [chemical binding]; other site 690566010901 active site 690566010902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566010903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566010904 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 690566010905 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 690566010906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 690566010907 putative substrate translocation pore; other site 690566010908 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 690566010909 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 690566010910 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566010911 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 690566010912 classical (c) SDRs; Region: SDR_c; cd05233 690566010913 NAD(P) binding site [chemical binding]; other site 690566010914 active site 690566010915 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566010916 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 690566010917 C-terminal domain interface [polypeptide binding]; other site 690566010918 GSH binding site (G-site) [chemical binding]; other site 690566010919 dimer interface [polypeptide binding]; other site 690566010920 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 690566010921 N-terminal domain interface [polypeptide binding]; other site 690566010922 dimer interface [polypeptide binding]; other site 690566010923 substrate binding pocket (H-site) [chemical binding]; other site 690566010924 D-galactonate transporter; Region: 2A0114; TIGR00893 690566010925 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010926 classical (c) SDRs; Region: SDR_c; cd05233 690566010927 NAD(P) binding site [chemical binding]; other site 690566010928 active site 690566010929 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566010930 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566010931 [2Fe-2S] cluster binding site [ion binding]; other site 690566010932 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 690566010933 alpha subunit interface [polypeptide binding]; other site 690566010934 active site 690566010935 substrate binding site [chemical binding]; other site 690566010936 Fe binding site [ion binding]; other site 690566010937 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566010938 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 690566010939 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 690566010940 substrate binding site [chemical binding]; other site 690566010941 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 690566010942 isopropylmalate isomerase large subunit; Validated; Region: PRK05478 690566010943 substrate binding site [chemical binding]; other site 690566010944 ligand binding site [chemical binding]; other site 690566010945 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 690566010946 active site 690566010947 catalytic residues [active] 690566010948 metal binding site [ion binding]; metal-binding site 690566010949 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566010950 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566010951 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566010952 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566010953 N-terminal plug; other site 690566010954 ligand-binding site [chemical binding]; other site 690566010955 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 690566010956 classical (c) SDRs; Region: SDR_c; cd05233 690566010957 NAD(P) binding site [chemical binding]; other site 690566010958 active site 690566010959 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 690566010960 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566010961 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566010962 acyl-activating enzyme (AAE) consensus motif; other site 690566010963 acyl-activating enzyme (AAE) consensus motif; other site 690566010964 putative active site [active] 690566010965 putative AMP binding site [chemical binding]; other site 690566010966 putative CoA binding site [chemical binding]; other site 690566010967 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 690566010968 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 690566010969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566010970 Zn binding site [ion binding]; other site 690566010971 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 690566010972 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010973 active site 690566010974 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 690566010975 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 690566010976 active site 690566010977 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 690566010978 homodimer interface [polypeptide binding]; other site 690566010979 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566010980 NAD binding site [chemical binding]; other site 690566010981 active site 690566010982 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 690566010983 putative active site [active] 690566010984 putative catalytic site [active] 690566010985 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 690566010986 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566010987 active site 690566010988 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 690566010989 DUF35 OB-fold domain; Region: DUF35; pfam01796 690566010990 beta-ketothiolase; Provisional; Region: PRK09051 690566010991 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566010992 dimer interface [polypeptide binding]; other site 690566010993 active site 690566010994 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 690566010995 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566010996 active site 690566010997 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 690566010998 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 690566010999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566011000 NAD(P) binding site [chemical binding]; other site 690566011001 active site 690566011002 4Fe-4S binding domain; Region: Fer4; pfam00037 690566011003 short chain dehydrogenase; Provisional; Region: PRK06180 690566011004 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 690566011005 NADP binding site [chemical binding]; other site 690566011006 active site 690566011007 steroid binding site; other site 690566011008 Cupin; Region: Cupin_6; pfam12852 690566011009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566011010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 690566011011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566011012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 690566011013 hypothetical protein; Provisional; Region: PRK09262 690566011014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566011015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566011016 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 690566011017 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566011018 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 690566011019 dimerization interface [polypeptide binding]; other site 690566011020 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 690566011021 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 690566011022 Amidohydrolase; Region: Amidohydro_2; pfam04909 690566011023 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 690566011024 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 690566011025 active site 690566011026 The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924 690566011027 dimer interface [polypeptide binding]; other site 690566011028 tetramer interface [polypeptide binding]; other site 690566011029 active site 690566011030 Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364 690566011031 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 690566011032 active site 690566011033 Fe(II) binding site [ion binding]; other site 690566011034 dimer interface [polypeptide binding]; other site 690566011035 tetramer interface [polypeptide binding]; other site 690566011036 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 690566011037 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 690566011038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566011039 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 690566011040 NAD(P) binding site [chemical binding]; other site 690566011041 catalytic residues [active] 690566011042 acyl-CoA synthetase; Validated; Region: PRK09088 690566011043 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 690566011044 acyl-activating enzyme (AAE) consensus motif; other site 690566011045 putative AMP binding site [chemical binding]; other site 690566011046 putative active site [active] 690566011047 putative CoA binding site [chemical binding]; other site 690566011048 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 690566011049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011050 substrate binding site [chemical binding]; other site 690566011051 oxyanion hole (OAH) forming residues; other site 690566011052 trimer interface [polypeptide binding]; other site 690566011053 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 690566011054 Putative cyclase; Region: Cyclase; pfam04199 690566011055 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 690566011056 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566011057 Predicted membrane protein [Function unknown]; Region: COG2259 690566011058 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011059 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011060 N-terminal plug; other site 690566011061 ligand-binding site [chemical binding]; other site 690566011062 Transcriptional regulators [Transcription]; Region: GntR; COG1802 690566011063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 690566011064 DNA-binding site [nucleotide binding]; DNA binding site 690566011065 FCD domain; Region: FCD; pfam07729 690566011066 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 690566011067 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 690566011068 DXD motif; other site 690566011069 PilZ domain; Region: PilZ; pfam07238 690566011070 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 690566011071 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 690566011072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011073 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 690566011074 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 690566011075 Fatty acid desaturase; Region: FA_desaturase; pfam00487 690566011076 putative di-iron ligands [ion binding]; other site 690566011077 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 690566011078 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566011079 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 690566011080 Uncharacterized conserved protein [Function unknown]; Region: COG5316 690566011081 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 690566011082 Uncharacterized conserved protein [Function unknown]; Region: COG5316 690566011083 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 690566011084 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566011085 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 690566011086 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 690566011087 Protein of unknown function (DUF328); Region: DUF328; pfam03883 690566011088 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 690566011089 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566011090 classical (c) SDRs; Region: SDR_c; cd05233 690566011091 NAD(P) binding site [chemical binding]; other site 690566011092 active site 690566011093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566011094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011095 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 690566011096 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566011097 Cytochrome P450; Region: p450; cl12078 690566011098 AMP-binding domain protein; Validated; Region: PRK07529 690566011099 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566011100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566011101 acyl-activating enzyme (AAE) consensus motif; other site 690566011102 acyl-activating enzyme (AAE) consensus motif; other site 690566011103 AMP binding site [chemical binding]; other site 690566011104 active site 690566011105 CoA binding site [chemical binding]; other site 690566011106 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566011107 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566011108 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 690566011109 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 690566011110 active site 690566011111 enoyl-CoA hydratase; Provisional; Region: PRK08252 690566011112 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011113 substrate binding site [chemical binding]; other site 690566011114 oxyanion hole (OAH) forming residues; other site 690566011115 trimer interface [polypeptide binding]; other site 690566011116 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 690566011117 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011118 DNA binding residues [nucleotide binding] 690566011119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566011120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011121 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 690566011122 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 690566011123 Cytochrome P450; Region: p450; cl12078 690566011124 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566011125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 690566011126 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 690566011127 Helix-turn-helix domain; Region: HTH_18; pfam12833 690566011128 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 690566011129 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566011130 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 690566011131 NAD(P) binding site [chemical binding]; other site 690566011132 catalytic residues [active] 690566011133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566011134 active site 690566011135 metal binding site [ion binding]; metal-binding site 690566011136 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 690566011137 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011138 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011139 N-terminal plug; other site 690566011140 ligand-binding site [chemical binding]; other site 690566011141 circadian clock protein KaiC; Reviewed; Region: PRK09302 690566011142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566011143 Walker A motif; other site 690566011144 ATP binding site [chemical binding]; other site 690566011145 Walker B motif; other site 690566011146 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566011147 Walker A motif; other site 690566011148 ATP binding site [chemical binding]; other site 690566011149 Walker B motif; other site 690566011150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566011151 PAS fold; Region: PAS_3; pfam08447 690566011152 putative active site [active] 690566011153 heme pocket [chemical binding]; other site 690566011154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 690566011155 GAF domain; Region: GAF; pfam01590 690566011156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 690566011157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566011158 ATP binding site [chemical binding]; other site 690566011159 Mg2+ binding site [ion binding]; other site 690566011160 G-X-G motif; other site 690566011161 Response regulator receiver domain; Region: Response_reg; pfam00072 690566011162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566011163 active site 690566011164 phosphorylation site [posttranslational modification] 690566011165 intermolecular recognition site; other site 690566011166 dimerization interface [polypeptide binding]; other site 690566011167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 690566011168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 690566011169 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 690566011170 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 690566011171 Secretin and TonB N terminus short domain; Region: STN; smart00965 690566011172 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 690566011173 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011174 N-terminal plug; other site 690566011175 ligand-binding site [chemical binding]; other site 690566011176 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 690566011177 FecR protein; Region: FecR; pfam04773 690566011178 RNA polymerase sigma factor; Reviewed; Region: PRK12527 690566011179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566011180 DNA binding residues [nucleotide binding] 690566011181 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 690566011182 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 690566011183 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 690566011184 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 690566011185 Phosphotransferase enzyme family; Region: APH; pfam01636 690566011186 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 690566011187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 690566011188 motif II; other site 690566011189 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 690566011190 Cupin domain; Region: Cupin_2; pfam07883 690566011191 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 690566011192 intersubunit interface [polypeptide binding]; other site 690566011193 active site 690566011194 Zn2+ binding site [ion binding]; other site 690566011195 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 690566011196 sulfite oxidase; Provisional; Region: PLN00177 690566011197 Moco binding site; other site 690566011198 metal coordination site [ion binding]; other site 690566011199 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011200 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011201 N-terminal plug; other site 690566011202 ligand-binding site [chemical binding]; other site 690566011203 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 690566011204 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566011205 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 690566011206 homotrimer interaction site [polypeptide binding]; other site 690566011207 putative active site [active] 690566011208 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 690566011209 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 690566011210 active site 690566011211 catalytic tetrad [active] 690566011212 Carboxylesterase family; Region: COesterase; pfam00135 690566011213 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 690566011214 substrate binding pocket [chemical binding]; other site 690566011215 catalytic triad [active] 690566011216 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566011217 dimerization interface [polypeptide binding]; other site 690566011218 putative DNA binding site [nucleotide binding]; other site 690566011219 putative Zn2+ binding site [ion binding]; other site 690566011220 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 690566011221 ArsC family; Region: ArsC; pfam03960 690566011222 catalytic residues [active] 690566011223 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 690566011224 amphipathic channel; other site 690566011225 Asn-Pro-Ala signature motifs; other site 690566011226 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 690566011227 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566011228 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 690566011229 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_3; cd06151 690566011230 homotrimer interaction site [polypeptide binding]; other site 690566011231 putative active site [active] 690566011232 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566011233 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 690566011234 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566011235 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566011236 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 690566011237 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566011238 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 690566011239 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 690566011240 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566011241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 690566011242 active site 690566011243 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 690566011244 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 690566011245 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566011246 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566011247 succinic semialdehyde dehydrogenase; Region: PLN02278 690566011248 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 690566011249 tetramerization interface [polypeptide binding]; other site 690566011250 NAD(P) binding site [chemical binding]; other site 690566011251 catalytic residues [active] 690566011252 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 690566011253 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 690566011254 tetramer interface [polypeptide binding]; other site 690566011255 TPP-binding site [chemical binding]; other site 690566011256 heterodimer interface [polypeptide binding]; other site 690566011257 phosphorylation loop region [posttranslational modification] 690566011258 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 690566011259 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 690566011260 alpha subunit interface [polypeptide binding]; other site 690566011261 TPP binding site [chemical binding]; other site 690566011262 heterodimer interface [polypeptide binding]; other site 690566011263 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 690566011264 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566011265 classical (c) SDRs; Region: SDR_c; cd05233 690566011266 NAD(P) binding site [chemical binding]; other site 690566011267 active site 690566011268 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 690566011269 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 690566011270 metal binding site [ion binding]; metal-binding site 690566011271 substrate binding pocket [chemical binding]; other site 690566011272 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 690566011273 classical (c) SDRs; Region: SDR_c; cd05233 690566011274 NAD(P) binding site [chemical binding]; other site 690566011275 active site 690566011276 enoyl-CoA hydratase; Provisional; Region: PRK06688 690566011277 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011278 substrate binding site [chemical binding]; other site 690566011279 oxyanion hole (OAH) forming residues; other site 690566011280 trimer interface [polypeptide binding]; other site 690566011281 putative acyl-CoA synthetase; Provisional; Region: PRK06018 690566011282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 690566011283 acyl-activating enzyme (AAE) consensus motif; other site 690566011284 AMP binding site [chemical binding]; other site 690566011285 active site 690566011286 CoA binding site [chemical binding]; other site 690566011287 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 690566011288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566011289 active site 690566011290 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 690566011291 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 690566011292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566011293 NAD(P) binding site [chemical binding]; other site 690566011294 active site 690566011295 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 690566011296 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 690566011297 putative catalytic residue [active] 690566011298 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 690566011299 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566011300 dimer interface [polypeptide binding]; other site 690566011301 active site 690566011302 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160 690566011303 active site 690566011304 Tannase and feruloyl esterase; Region: Tannase; pfam07519 690566011305 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 690566011306 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011307 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011308 N-terminal plug; other site 690566011309 ligand-binding site [chemical binding]; other site 690566011310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566011311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011312 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 690566011313 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011314 substrate binding site [chemical binding]; other site 690566011315 oxyanion hole (OAH) forming residues; other site 690566011316 trimer interface [polypeptide binding]; other site 690566011317 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 690566011318 short chain dehydrogenase; Provisional; Region: PRK07677 690566011319 NAD(P) binding site [chemical binding]; other site 690566011320 substrate binding site [chemical binding]; other site 690566011321 homotetramer interface [polypeptide binding]; other site 690566011322 active site 690566011323 homodimer interface [polypeptide binding]; other site 690566011324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566011325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011326 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011327 enoyl-CoA hydratase; Provisional; Region: PRK05981 690566011328 substrate binding site [chemical binding]; other site 690566011329 oxyanion hole (OAH) forming residues; other site 690566011330 trimer interface [polypeptide binding]; other site 690566011331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 690566011332 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 690566011333 active site 690566011334 EthD domain; Region: EthD; pfam07110 690566011335 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 690566011336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 690566011337 NAD(P) binding site [chemical binding]; other site 690566011338 active site 690566011339 enoyl-CoA hydratase; Provisional; Region: PRK07509 690566011340 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011341 substrate binding site [chemical binding]; other site 690566011342 oxyanion hole (OAH) forming residues; other site 690566011343 trimer interface [polypeptide binding]; other site 690566011344 acetyl-CoA acetyltransferase; Provisional; Region: PRK06504 690566011345 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566011346 dimer interface [polypeptide binding]; other site 690566011347 active site 690566011348 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 690566011349 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 690566011350 acyl-activating enzyme (AAE) consensus motif; other site 690566011351 putative AMP binding site [chemical binding]; other site 690566011352 putative active site [active] 690566011353 putative CoA binding site [chemical binding]; other site 690566011354 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 690566011355 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 690566011356 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 690566011357 enoyl-CoA hydratase; Provisional; Region: PRK06190 690566011358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 690566011359 substrate binding site [chemical binding]; other site 690566011360 oxyanion hole (OAH) forming residues; other site 690566011361 trimer interface [polypeptide binding]; other site 690566011362 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 690566011363 CoA-transferase family III; Region: CoA_transf_3; pfam02515 690566011364 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011365 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011366 N-terminal plug; other site 690566011367 ligand-binding site [chemical binding]; other site 690566011368 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 690566011369 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 690566011370 [2Fe-2S] cluster binding site [ion binding]; other site 690566011371 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 690566011372 alpha subunit interface [polypeptide binding]; other site 690566011373 active site 690566011374 substrate binding site [chemical binding]; other site 690566011375 Fe binding site [ion binding]; other site 690566011376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 690566011377 classical (c) SDRs; Region: SDR_c; cd05233 690566011378 NAD(P) binding site [chemical binding]; other site 690566011379 active site 690566011380 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 690566011381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011382 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 690566011383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 690566011384 putative active site [active] 690566011385 putative metal binding site [ion binding]; other site 690566011386 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566011387 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 690566011388 hypothetical protein; Provisional; Region: PRK06126 690566011389 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566011390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 690566011391 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 690566011392 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 690566011393 putative FMN binding site [chemical binding]; other site 690566011394 Predicted transcriptional regulators [Transcription]; Region: COG1733 690566011395 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 690566011396 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 690566011397 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 690566011398 aminodeoxychorismate synthase; Provisional; Region: PRK07508 690566011399 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 690566011400 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 690566011401 glutathionine S-transferase; Provisional; Region: PRK10542 690566011402 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 690566011403 C-terminal domain interface [polypeptide binding]; other site 690566011404 GSH binding site (G-site) [chemical binding]; other site 690566011405 dimer interface [polypeptide binding]; other site 690566011406 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 690566011407 dimer interface [polypeptide binding]; other site 690566011408 N-terminal domain interface [polypeptide binding]; other site 690566011409 substrate binding pocket (H-site) [chemical binding]; other site 690566011410 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 690566011411 putative hydrolase; Provisional; Region: PRK11460 690566011412 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 690566011413 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 690566011414 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 690566011415 active site 690566011416 dimer interface [polypeptide binding]; other site 690566011417 metal binding site [ion binding]; metal-binding site 690566011418 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 690566011419 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 690566011420 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 690566011421 putative active site [active] 690566011422 putative substrate binding site [chemical binding]; other site 690566011423 putative cosubstrate binding site; other site 690566011424 catalytic site [active] 690566011425 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 690566011426 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 690566011427 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 690566011428 homodimer interface [polypeptide binding]; other site 690566011429 NADP binding site [chemical binding]; other site 690566011430 substrate binding site [chemical binding]; other site 690566011431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566011432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566011433 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 690566011434 substrate binding pocket [chemical binding]; other site 690566011435 dimerization interface [polypeptide binding]; other site 690566011436 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 690566011437 Zn binding site [ion binding]; other site 690566011438 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 690566011439 Zn binding site [ion binding]; other site 690566011440 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 690566011441 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 690566011442 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 690566011443 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011444 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011445 N-terminal plug; other site 690566011446 ligand-binding site [chemical binding]; other site 690566011447 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566011448 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 690566011449 C-terminal domain interface [polypeptide binding]; other site 690566011450 GSH binding site (G-site) [chemical binding]; other site 690566011451 dimer interface [polypeptide binding]; other site 690566011452 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 690566011453 N-terminal domain interface [polypeptide binding]; other site 690566011454 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 690566011455 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 690566011456 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 690566011457 putative dimer interface [polypeptide binding]; other site 690566011458 N-terminal domain interface [polypeptide binding]; other site 690566011459 putative substrate binding pocket (H-site) [chemical binding]; other site 690566011460 Transcriptional regulator [Transcription]; Region: LysR; COG0583 690566011461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566011462 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 690566011463 substrate binding pocket [chemical binding]; other site 690566011464 dimerization interface [polypeptide binding]; other site 690566011465 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 690566011466 FAD binding site [chemical binding]; other site 690566011467 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 690566011468 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 690566011469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011470 DNA binding residues [nucleotide binding] 690566011471 dimerization interface [polypeptide binding]; other site 690566011472 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 690566011473 Predicted oxidoreductase [General function prediction only]; Region: COG3573 690566011474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 690566011475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 690566011476 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 690566011477 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 690566011478 dimer interface [polypeptide binding]; other site 690566011479 active site 690566011480 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 690566011481 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011482 N-terminal plug; other site 690566011483 ligand-binding site [chemical binding]; other site 690566011484 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 690566011485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566011486 dimer interface [polypeptide binding]; other site 690566011487 phosphorylation site [posttranslational modification] 690566011488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566011489 ATP binding site [chemical binding]; other site 690566011490 Mg2+ binding site [ion binding]; other site 690566011491 G-X-G motif; other site 690566011492 Response regulator receiver domain; Region: Response_reg; pfam00072 690566011493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566011494 active site 690566011495 phosphorylation site [posttranslational modification] 690566011496 intermolecular recognition site; other site 690566011497 dimerization interface [polypeptide binding]; other site 690566011498 PilZ domain; Region: PilZ; pfam07238 690566011499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566011500 sequence-specific DNA binding site [nucleotide binding]; other site 690566011501 salt bridge; other site 690566011502 YciI-like protein; Reviewed; Region: PRK12863 690566011503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566011504 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 690566011505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 690566011506 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 690566011507 dimer interface [polypeptide binding]; other site 690566011508 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 690566011509 active site 690566011510 YciI-like protein; Reviewed; Region: PRK12863 690566011511 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566011512 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 690566011513 C-terminal domain interface [polypeptide binding]; other site 690566011514 GSH binding site (G-site) [chemical binding]; other site 690566011515 dimer interface [polypeptide binding]; other site 690566011516 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 690566011517 N-terminal domain interface [polypeptide binding]; other site 690566011518 dimer interface [polypeptide binding]; other site 690566011519 substrate binding pocket (H-site) [chemical binding]; other site 690566011520 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 690566011521 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 690566011522 putative C-terminal domain interface [polypeptide binding]; other site 690566011523 putative GSH binding site (G-site) [chemical binding]; other site 690566011524 putative dimer interface [polypeptide binding]; other site 690566011525 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 690566011526 putative N-terminal domain interface [polypeptide binding]; other site 690566011527 putative dimer interface [polypeptide binding]; other site 690566011528 putative substrate binding pocket (H-site) [chemical binding]; other site 690566011529 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 690566011530 putative FMN binding site [chemical binding]; other site 690566011531 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011532 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 690566011533 N-terminal plug; other site 690566011534 ligand-binding site [chemical binding]; other site 690566011535 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 690566011536 putative FMN binding site [chemical binding]; other site 690566011537 hypothetical protein; Provisional; Region: PRK09133 690566011538 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 690566011539 putative metal binding site [ion binding]; other site 690566011540 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566011541 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 690566011542 NAD(P) binding site [chemical binding]; other site 690566011543 catalytic residues [active] 690566011544 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 690566011545 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 690566011546 tricarballylate dehydrogenase; Validated; Region: PRK08274 690566011547 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 690566011548 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 690566011549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 690566011550 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 690566011551 substrate binding site [chemical binding]; other site 690566011552 dimerization interface [polypeptide binding]; other site 690566011553 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 690566011554 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 690566011555 metal binding site [ion binding]; metal-binding site 690566011556 substrate binding pocket [chemical binding]; other site 690566011557 choline dehydrogenase; Validated; Region: PRK02106 690566011558 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 690566011559 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 690566011560 Strictosidine synthase; Region: Str_synth; pfam03088 690566011561 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566011562 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 690566011563 NAD(P) binding site [chemical binding]; other site 690566011564 catalytic residues [active] 690566011565 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 690566011566 SnoaL-like domain; Region: SnoaL_2; pfam12680 690566011567 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 690566011568 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 690566011569 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 690566011570 succinic semialdehyde dehydrogenase; Region: PLN02278 690566011571 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 690566011572 tetramerization interface [polypeptide binding]; other site 690566011573 NAD(P) binding site [chemical binding]; other site 690566011574 catalytic residues [active] 690566011575 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 690566011576 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 690566011577 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 690566011578 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 690566011579 PYR/PP interface [polypeptide binding]; other site 690566011580 dimer interface [polypeptide binding]; other site 690566011581 TPP binding site [chemical binding]; other site 690566011582 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 690566011583 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 690566011584 TPP-binding site [chemical binding]; other site 690566011585 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 690566011586 classical (c) SDRs; Region: SDR_c; cd05233 690566011587 NAD(P) binding site [chemical binding]; other site 690566011588 active site 690566011589 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 690566011590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 690566011591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 690566011592 DNA binding site [nucleotide binding] 690566011593 domain linker motif; other site 690566011594 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 690566011595 putative dimerization interface [polypeptide binding]; other site 690566011596 putative ligand binding site [chemical binding]; other site 690566011597 Amidohydrolase; Region: Amidohydro_4; pfam13147 690566011598 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 690566011599 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 690566011600 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 690566011601 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 690566011602 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 690566011603 dimerization interface [polypeptide binding]; other site 690566011604 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 690566011605 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 690566011606 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 690566011607 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 690566011608 FAD binding pocket [chemical binding]; other site 690566011609 FAD binding motif [chemical binding]; other site 690566011610 phosphate binding motif [ion binding]; other site 690566011611 beta-alpha-beta structure motif; other site 690566011612 NAD binding pocket [chemical binding]; other site 690566011613 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 690566011614 catalytic loop [active] 690566011615 iron binding site [ion binding]; other site 690566011616 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 690566011617 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 690566011618 DNA binding residues [nucleotide binding] 690566011619 dimer interface [polypeptide binding]; other site 690566011620 metal binding site [ion binding]; metal-binding site 690566011621 Outer membrane efflux protein; Region: OEP; pfam02321 690566011622 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 690566011623 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566011624 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 690566011625 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 690566011626 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 690566011627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566011628 Coenzyme A binding pocket [chemical binding]; other site 690566011629 multiple promoter invertase; Provisional; Region: mpi; PRK13413 690566011630 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 690566011631 catalytic residues [active] 690566011632 catalytic nucleophile [active] 690566011633 Presynaptic Site I dimer interface [polypeptide binding]; other site 690566011634 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 690566011635 Synaptic Flat tetramer interface [polypeptide binding]; other site 690566011636 Synaptic Site I dimer interface [polypeptide binding]; other site 690566011637 DNA binding site [nucleotide binding] 690566011638 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 690566011639 DNA-binding interface [nucleotide binding]; DNA binding site 690566011640 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 690566011641 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 690566011642 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 690566011643 Eukaryotic phosphomannomutase; Region: PMM; cl17107 690566011644 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 690566011645 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 690566011646 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 690566011647 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 690566011648 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 690566011649 putative hydrophobic ligand binding site [chemical binding]; other site 690566011650 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 690566011651 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 690566011652 HlyD family secretion protein; Region: HlyD_3; pfam13437 690566011653 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 690566011654 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 690566011655 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 690566011656 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 690566011657 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 690566011658 DNA binding residues [nucleotide binding] 690566011659 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 690566011660 dimer interface [polypeptide binding]; other site 690566011661 putative metal binding site [ion binding]; other site 690566011662 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 690566011663 protein binding site [polypeptide binding]; other site 690566011664 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 690566011665 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 690566011666 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 690566011667 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 690566011668 catalytic residues [active] 690566011669 catalytic nucleophile [active] 690566011670 Presynaptic Site I dimer interface [polypeptide binding]; other site 690566011671 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 690566011672 Synaptic Flat tetramer interface [polypeptide binding]; other site 690566011673 Synaptic Site I dimer interface [polypeptide binding]; other site 690566011674 DNA binding site [nucleotide binding] 690566011675 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 690566011676 DNA-binding interface [nucleotide binding]; DNA binding site 690566011677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 690566011678 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 690566011679 RES domain; Region: RES; smart00953 690566011680 ParB-like nuclease domain; Region: ParBc; pfam02195 690566011681 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566011682 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 690566011683 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 690566011684 DNA binding residues [nucleotide binding] 690566011685 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566011686 P-loop; other site 690566011687 Magnesium ion binding site [ion binding]; other site 690566011688 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566011689 Magnesium ion binding site [ion binding]; other site 690566011690 Initiator Replication protein; Region: Rep_3; pfam01051 690566011691 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 690566011692 dimer interface [polypeptide binding]; other site 690566011693 ssDNA binding site [nucleotide binding]; other site 690566011694 tetramer (dimer of dimers) interface [polypeptide binding]; other site 690566011695 Toprim domain; Region: Toprim_3; pfam13362 690566011696 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 690566011697 Helicase_C-like; Region: Helicase_C_4; pfam13871 690566011698 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 690566011699 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 690566011700 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 690566011701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 690566011702 putative DNA binding site [nucleotide binding]; other site 690566011703 putative Zn2+ binding site [ion binding]; other site 690566011704 Low molecular weight phosphatase family; Region: LMWPc; cd00115 690566011705 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 690566011706 active site 690566011707 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 690566011708 ArsC family; Region: ArsC; pfam03960 690566011709 catalytic residues [active] 690566011710 Sodium Bile acid symporter family; Region: SBF; cl17470 690566011711 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 690566011712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 690566011713 Coenzyme A binding pocket [chemical binding]; other site 690566011714 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 690566011715 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 690566011716 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 690566011717 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 690566011718 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 690566011719 dimer interface [polypeptide binding]; other site 690566011720 ssDNA binding site [nucleotide binding]; other site 690566011721 tetramer (dimer of dimers) interface [polypeptide binding]; other site 690566011722 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 690566011723 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 690566011724 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 690566011725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566011726 P-loop; other site 690566011727 Magnesium ion binding site [ion binding]; other site 690566011728 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 690566011729 Magnesium ion binding site [ion binding]; other site 690566011730 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 690566011731 ParB-like nuclease domain; Region: ParB; smart00470 690566011732 KorB domain; Region: KorB; pfam08535 690566011733 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 690566011734 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 690566011735 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 690566011736 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 690566011737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 690566011738 salt bridge; other site 690566011739 non-specific DNA binding site [nucleotide binding]; other site 690566011740 sequence-specific DNA binding site [nucleotide binding]; other site 690566011741 Methyltransferase domain; Region: Methyltransf_26; pfam13659 690566011742 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 690566011743 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 690566011744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 690566011745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 690566011746 ABC transporter signature motif; other site 690566011747 Walker B; other site 690566011748 D-loop; other site 690566011749 H-loop/switch region; other site 690566011750 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 690566011751 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 690566011752 Walker A motif; other site 690566011753 ATP binding site [chemical binding]; other site 690566011754 Walker B motif; other site 690566011755 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 690566011756 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 690566011757 Walker A motif; other site 690566011758 hexamer interface [polypeptide binding]; other site 690566011759 ATP binding site [chemical binding]; other site 690566011760 Walker B motif; other site 690566011761 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 690566011762 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 690566011763 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 690566011764 VirB7 interaction site; other site 690566011765 VirB8 protein; Region: VirB8; cl01500 690566011766 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 690566011767 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 690566011768 Type IV secretion system proteins; Region: T4SS; pfam07996 690566011769 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 690566011770 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 690566011771 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 690566011772 TrbC/VIRB2 family; Region: TrbC; pfam04956 690566011773 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 690566011774 N-acetyl-D-glucosamine binding site [chemical binding]; other site 690566011775 catalytic residue [active] 690566011776 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 690566011777 Autoinducer synthetase; Region: Autoind_synth; cl17404 690566011778 transcriptional regulator TraR; Provisional; Region: PRK13870 690566011779 Autoinducer binding domain; Region: Autoind_bind; pfam03472 690566011780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011781 DNA binding residues [nucleotide binding] 690566011782 dimerization interface [polypeptide binding]; other site 690566011783 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 690566011784 Autoinducer binding domain; Region: Autoind_bind; pfam03472 690566011785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011786 DNA binding residues [nucleotide binding] 690566011787 dimerization interface [polypeptide binding]; other site 690566011788 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 690566011789 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 690566011790 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 690566011791 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 690566011792 Beta-Casp domain; Region: Beta-Casp; smart01027 690566011793 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 690566011794 thymidine phosphorylase; Provisional; Region: PRK04350 690566011795 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 690566011796 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 690566011797 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 690566011798 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199 690566011799 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 690566011800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 690566011801 active site 690566011802 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 690566011803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566011804 active site 690566011805 phosphorylation site [posttranslational modification] 690566011806 intermolecular recognition site; other site 690566011807 dimerization interface [polypeptide binding]; other site 690566011808 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011809 DNA binding residues [nucleotide binding] 690566011810 dimerization interface [polypeptide binding]; other site 690566011811 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 690566011812 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 690566011813 DNA binding residues [nucleotide binding] 690566011814 dimer interface [polypeptide binding]; other site 690566011815 copper binding site [ion binding]; other site 690566011816 YHS domain; Region: YHS; pfam04945 690566011817 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 690566011818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 690566011819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 690566011820 active site 690566011821 motif I; other site 690566011822 motif II; other site 690566011823 Copper resistance protein D; Region: CopD; pfam05425 690566011824 CopC domain; Region: CopC; pfam04234 690566011825 Heavy-metal resistance; Region: Metal_resist; pfam13801 690566011826 dimer interface [polypeptide binding]; other site 690566011827 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 690566011828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 690566011829 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 690566011830 DNA binding residues [nucleotide binding] 690566011831 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 690566011832 Multicopper oxidase; Region: Cu-oxidase; pfam00394 690566011833 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 690566011834 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 690566011835 Domain of unknown function (DUF305); Region: DUF305; cl17794 690566011836 PAS domain; Region: PAS_9; pfam13426 690566011837 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 690566011838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 690566011839 putative active site [active] 690566011840 heme pocket [chemical binding]; other site 690566011841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 690566011842 dimer interface [polypeptide binding]; other site 690566011843 phosphorylation site [posttranslational modification] 690566011844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 690566011845 ATP binding site [chemical binding]; other site 690566011846 Mg2+ binding site [ion binding]; other site 690566011847 G-X-G motif; other site 690566011848 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 690566011849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566011850 active site 690566011851 phosphorylation site [posttranslational modification] 690566011852 intermolecular recognition site; other site 690566011853 dimerization interface [polypeptide binding]; other site 690566011854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 690566011855 DNA binding residues [nucleotide binding] 690566011856 dimerization interface [polypeptide binding]; other site 690566011857 Response regulator receiver domain; Region: Response_reg; pfam00072 690566011858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 690566011859 active site 690566011860 phosphorylation site [posttranslational modification] 690566011861 intermolecular recognition site; other site 690566011862 dimerization interface [polypeptide binding]; other site 690566011863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 690566011864 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 690566011865 Protein of unknown function, DUF; Region: DUF411; cl01142 690566011866 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 690566011867 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 690566011868 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 690566011869 Multicopper oxidase; Region: Cu-oxidase; pfam00394 690566011870 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 690566011871 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 690566011872 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 690566011873 NAD binding site [chemical binding]; other site 690566011874 substrate binding site [chemical binding]; other site 690566011875 catalytic Zn binding site [ion binding]; other site 690566011876 tetramer interface [polypeptide binding]; other site 690566011877 structural Zn binding site [ion binding]; other site 690566011878 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559 690566011879 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 690566011880 NAD(P) binding site [chemical binding]; other site 690566011881 catalytic residues [active]