-- dump date   	20140620_071914
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
745310000001	Methyltransferase domain; Region: Methyltransf_26; pfam13659
745310000002	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
745310000003	Toprim domain; Region: Toprim_3; pfam13362
745310000004	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
745310000005	dimer interface [polypeptide binding]; other site
745310000006	ssDNA binding site [nucleotide binding]; other site
745310000007	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310000008	Initiator Replication protein; Region: Rep_3; pfam01051
745310000009	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
745310000010	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310000011	DNA binding residues [nucleotide binding]
745310000012	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310000013	P-loop; other site
745310000014	Magnesium ion binding site [ion binding]; other site
745310000015	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310000016	Magnesium ion binding site [ion binding]; other site
745310000017	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
745310000018	ParB-like nuclease domain; Region: ParBc; pfam02195
745310000019	RES domain; Region: RES; smart00953
745310000020	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
745310000021	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310000022	active site
745310000023	DNA binding site [nucleotide binding]
745310000024	Int/Topo IB signature motif; other site
745310000025	AAA domain; Region: AAA_22; pfam13401
745310000026	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
745310000027	Helix-turn-helix domain; Region: HTH_28; pfam13518
745310000028	Winged helix-turn helix; Region: HTH_29; pfam13551
745310000029	Integrase core domain; Region: rve; pfam00665
745310000030	Integrase core domain; Region: rve_3; cl15866
745310000031	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
745310000032	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000033	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000034	catalytic residues [active]
745310000035	catalytic nucleophile [active]
745310000036	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000037	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000038	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000039	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000040	DNA binding site [nucleotide binding]
745310000041	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
745310000042	DNA-binding interface [nucleotide binding]; DNA binding site
745310000043	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
745310000044	catalytic motif [active]
745310000045	Catalytic residue [active]
745310000046	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310000047	Integrase core domain; Region: rve; pfam00665
745310000048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310000049	Walker A motif; other site
745310000050	ATP binding site [chemical binding]; other site
745310000051	Walker B motif; other site
745310000052	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
745310000053	protein binding site [polypeptide binding]; other site
745310000054	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
745310000055	DNA binding residues [nucleotide binding]
745310000056	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
745310000057	dimer interface [polypeptide binding]; other site
745310000058	putative metal binding site [ion binding]; other site
745310000059	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310000060	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
745310000061	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
745310000062	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310000063	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
745310000064	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310000065	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
745310000066	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
745310000067	putative hydrophobic ligand binding site [chemical binding]; other site
745310000068	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310000069	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
745310000070	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310000071	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
745310000072	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
745310000073	Eukaryotic phosphomannomutase; Region: PMM; cl17107
745310000074	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000075	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310000076	catalytic residues [active]
745310000077	catalytic nucleophile [active]
745310000078	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000079	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000080	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000081	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000082	DNA binding site [nucleotide binding]
745310000083	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000084	DNA-binding interface [nucleotide binding]; DNA binding site
745310000085	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
745310000086	DNA binding residues [nucleotide binding]
745310000087	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
745310000088	dimer interface [polypeptide binding]; other site
745310000089	putative metal binding site [ion binding]; other site
745310000090	MerT mercuric transport protein; Region: MerT; cl03578
745310000091	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000092	metal-binding site [ion binding]
745310000093	mercuric reductase; Region: MerA; TIGR02053
745310000094	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310000095	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
745310000096	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000097	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000098	H+ Antiporter protein; Region: 2A0121; TIGR00900
745310000099	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
745310000100	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310000101	Walker A motif; other site
745310000102	ATP binding site [chemical binding]; other site
745310000103	Walker B motif; other site
745310000104	Predicted ATPase [General function prediction only]; Region: COG3911
745310000105	AAA domain; Region: AAA_28; pfam13521
745310000106	Conjugal transfer protein TraD; Region: TraD; pfam06412
745310000107	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
745310000108	MobA/MobL family; Region: MobA_MobL; pfam03389
745310000109	AAA domain; Region: AAA_30; pfam13604
745310000110	Family description; Region: UvrD_C_2; pfam13538
745310000111	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
745310000112	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310000113	Walker A/P-loop; other site
745310000114	ATP binding site [chemical binding]; other site
745310000115	Q-loop/lid; other site
745310000116	ABC transporter signature motif; other site
745310000117	Walker B; other site
745310000118	D-loop; other site
745310000119	H-loop/switch region; other site
745310000120	Transposase domain (DUF772); Region: DUF772; pfam05598
745310000121	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310000122	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
745310000123	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
745310000124	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000125	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000126	catalytic residues [active]
745310000127	catalytic nucleophile [active]
745310000128	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000129	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000130	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000131	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000132	DNA binding site [nucleotide binding]
745310000133	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000134	DNA-binding interface [nucleotide binding]; DNA binding site
745310000135	potential frameshift: common BLAST hit: gi|410687270|ref|YP_006965784.1| Transposase
745310000136	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
745310000137	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
745310000138	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
745310000139	active site
745310000140	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
745310000141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310000142	active site
745310000143	phosphorylation site [posttranslational modification]
745310000144	intermolecular recognition site; other site
745310000145	dimerization interface [polypeptide binding]; other site
745310000146	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310000147	DNA binding residues [nucleotide binding]
745310000148	dimerization interface [polypeptide binding]; other site
745310000149	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
745310000150	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
745310000151	DNA binding residues [nucleotide binding]
745310000152	dimer interface [polypeptide binding]; other site
745310000153	copper binding site [ion binding]; other site
745310000154	YHS domain; Region: YHS; pfam04945
745310000155	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
745310000156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310000157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310000158	active site
745310000159	motif I; other site
745310000160	motif II; other site
745310000161	Copper resistance protein D; Region: CopD; pfam05425
745310000162	CopC domain; Region: CopC; pfam04234
745310000163	Heavy-metal resistance; Region: Metal_resist; pfam13801
745310000164	dimer interface [polypeptide binding]; other site
745310000165	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
745310000166	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310000167	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310000168	DNA binding residues [nucleotide binding]
745310000169	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
745310000170	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
745310000171	Multicopper oxidase; Region: Cu-oxidase; pfam00394
745310000172	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
745310000173	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
745310000174	Domain of unknown function (DUF305); Region: DUF305; cl17794
745310000175	PAS domain; Region: PAS_9; pfam13426
745310000176	PAS domain S-box; Region: sensory_box; TIGR00229
745310000177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310000178	putative active site [active]
745310000179	heme pocket [chemical binding]; other site
745310000180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310000181	dimer interface [polypeptide binding]; other site
745310000182	phosphorylation site [posttranslational modification]
745310000183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310000184	ATP binding site [chemical binding]; other site
745310000185	Mg2+ binding site [ion binding]; other site
745310000186	G-X-G motif; other site
745310000187	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
745310000188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310000189	active site
745310000190	phosphorylation site [posttranslational modification]
745310000191	intermolecular recognition site; other site
745310000192	dimerization interface [polypeptide binding]; other site
745310000193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310000194	DNA binding residues [nucleotide binding]
745310000195	dimerization interface [polypeptide binding]; other site
745310000196	Response regulator receiver domain; Region: Response_reg; pfam00072
745310000197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310000198	active site
745310000199	phosphorylation site [posttranslational modification]
745310000200	intermolecular recognition site; other site
745310000201	dimerization interface [polypeptide binding]; other site
745310000202	potential frameshift: common BLAST hit: gi|294010482|ref|YP_003543942.1| MIT-family metal ion transporter
745310000203	short chain dehydrogenase; Provisional; Region: PRK06482
745310000204	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310000205	NAD(P) binding site [chemical binding]; other site
745310000206	active site
745310000207	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310000208	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310000209	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310000210	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310000211	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
745310000212	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
745310000213	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
745310000214	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310000215	DNA-binding site [nucleotide binding]; DNA binding site
745310000216	UTRA domain; Region: UTRA; pfam07702
745310000217	Protein of unknown function, DUF; Region: DUF411; cl01142
745310000218	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310000219	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310000220	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
745310000221	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
745310000222	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
745310000223	Multicopper oxidase; Region: Cu-oxidase; pfam00394
745310000224	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
745310000225	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
745310000226	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
745310000227	NAD binding site [chemical binding]; other site
745310000228	substrate binding site [chemical binding]; other site
745310000229	catalytic Zn binding site [ion binding]; other site
745310000230	tetramer interface [polypeptide binding]; other site
745310000231	structural Zn binding site [ion binding]; other site
745310000232	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
745310000233	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310000234	NAD(P) binding site [chemical binding]; other site
745310000235	catalytic residues [active]
745310000236	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
745310000237	active site
745310000238	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
745310000239	dimerization interface [polypeptide binding]; other site
745310000240	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
745310000241	Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447
745310000242	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
745310000243	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
745310000244	FAD binding pocket [chemical binding]; other site
745310000245	FAD binding motif [chemical binding]; other site
745310000246	phosphate binding motif [ion binding]; other site
745310000247	beta-alpha-beta structure motif; other site
745310000248	NAD binding pocket [chemical binding]; other site
745310000249	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310000250	catalytic loop [active]
745310000251	iron binding site [ion binding]; other site
745310000252	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
745310000253	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
745310000254	DNA binding residues [nucleotide binding]
745310000255	dimer interface [polypeptide binding]; other site
745310000256	metal binding site [ion binding]; metal-binding site
745310000257	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000258	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000259	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
745310000260	active site
745310000261	NTP binding site [chemical binding]; other site
745310000262	metal binding triad [ion binding]; metal-binding site
745310000263	antibiotic binding site [chemical binding]; other site
745310000264	Protein of unknown function DUF86; Region: DUF86; cl01031
745310000265	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310000266	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310000267	Integrase core domain; Region: rve; pfam00665
745310000268	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
745310000269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310000270	NAD(P) binding site [chemical binding]; other site
745310000271	active site
745310000272	potential frameshift: common BLAST hit: gi|294010537|ref|YP_003543997.1| Tn3-family transposase
745310000273	potential protein location (hypothetical protein) that overlaps protein (Transposase)
745310000274	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000275	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000276	catalytic residues [active]
745310000277	catalytic nucleophile [active]
745310000278	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000279	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000280	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000281	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000282	DNA binding site [nucleotide binding]
745310000283	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000284	DNA-binding interface [nucleotide binding]; DNA binding site
745310000285	Predicted esterase [General function prediction only]; Region: COG0400
745310000286	Serine hydrolase (FSH1); Region: FSH1; pfam03959
745310000287	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
745310000288	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
745310000289	active site
745310000290	dimer interface [polypeptide binding]; other site
745310000291	metal binding site [ion binding]; metal-binding site
745310000292	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310000293	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310000294	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
745310000295	substrate binding pocket [chemical binding]; other site
745310000296	dimerization interface [polypeptide binding]; other site
745310000297	potential frameshift: common BLAST hit: gi|294146914|ref|YP_003559580.1| 2,6-dichloro-p-hydroquinone 1,2-dioxygenase LinEb
745310000298	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310000299	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310000300	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
745310000301	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
745310000302	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
745310000303	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
745310000304	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
745310000305	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
745310000306	putative dimer interface [polypeptide binding]; other site
745310000307	N-terminal domain interface [polypeptide binding]; other site
745310000308	putative substrate binding pocket (H-site) [chemical binding]; other site
745310000309	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310000310	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
745310000311	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310000312	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
745310000313	FMN binding site [chemical binding]; other site
745310000314	active site
745310000315	substrate binding site [chemical binding]; other site
745310000316	catalytic residue [active]
745310000317	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310000318	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310000319	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
745310000320	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
745310000321	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
745310000322	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
745310000323	catalytic Zn binding site [ion binding]; other site
745310000324	NAD binding site [chemical binding]; other site
745310000325	structural Zn binding site [ion binding]; other site
745310000326	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
745310000327	Cytochrome P450; Region: p450; cl12078
745310000328	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
745310000329	active site
745310000330	catalytic site [active]
745310000331	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
745310000332	active site 2 [active]
745310000333	active site 1 [active]
745310000334	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310000335	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310000336	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310000337	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310000338	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310000339	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
745310000340	NAD(P) binding site [chemical binding]; other site
745310000341	catalytic residues [active]
745310000342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310000343	NAD(P) binding site [chemical binding]; other site
745310000344	active site
745310000345	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
745310000346	DUF35 OB-fold domain; Region: DUF35; pfam01796
745310000347	thiolase; Provisional; Region: PRK06158
745310000348	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
745310000349	active site
745310000350	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310000351	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310000352	N-terminal plug; other site
745310000353	ligand-binding site [chemical binding]; other site
745310000354	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310000355	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
745310000356	tetramerization interface [polypeptide binding]; other site
745310000357	NAD(P) binding site [chemical binding]; other site
745310000358	catalytic residues [active]
745310000359	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
745310000360	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
745310000361	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310000362	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310000363	NAD(P) binding site [chemical binding]; other site
745310000364	active site
745310000365	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
745310000366	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
745310000367	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
745310000368	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
745310000369	NAD(P) binding site [chemical binding]; other site
745310000370	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310000371	classical (c) SDRs; Region: SDR_c; cd05233
745310000372	NAD(P) binding site [chemical binding]; other site
745310000373	active site
745310000374	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310000375	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310000376	N-terminal plug; other site
745310000377	ligand-binding site [chemical binding]; other site
745310000378	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
745310000379	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310000380	FMN binding site [chemical binding]; other site
745310000381	substrate binding site [chemical binding]; other site
745310000382	putative catalytic residue [active]
745310000383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310000384	WHG domain; Region: WHG; pfam13305
745310000385	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310000386	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
745310000387	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
745310000388	Prostaglandin dehydrogenases; Region: PGDH; cd05288
745310000389	NAD(P) binding site [chemical binding]; other site
745310000390	substrate binding site [chemical binding]; other site
745310000391	dimer interface [polypeptide binding]; other site
745310000392	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
745310000393	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310000394	dimer interface [polypeptide binding]; other site
745310000395	active site
745310000396	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
745310000397	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
745310000398	Bacterial transcriptional regulator; Region: IclR; pfam01614
745310000399	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
745310000400	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
745310000401	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
745310000402	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
745310000403	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310000404	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310000405	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000406	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000407	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000408	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000409	catalytic residues [active]
745310000410	catalytic nucleophile [active]
745310000411	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000412	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000413	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000414	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000415	DNA binding site [nucleotide binding]
745310000416	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000417	DNA-binding interface [nucleotide binding]; DNA binding site
745310000418	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310000419	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310000420	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
745310000421	dimerization interface [polypeptide binding]; other site
745310000422	Transcriptional regulator; Region: Rrf2; cl17282
745310000423	Rrf2 family protein; Region: rrf2_super; TIGR00738
745310000424	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
745310000425	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
745310000426	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
745310000427	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
745310000428	Fusaric acid resistance protein family; Region: FUSC; pfam04632
745310000429	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
745310000430	Protein of unknown function (DUF1656); Region: DUF1656; cl11658
745310000431	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
745310000432	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310000433	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310000434	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310000435	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000436	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000437	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000438	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000439	catalytic residues [active]
745310000440	catalytic nucleophile [active]
745310000441	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000442	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000443	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000444	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000445	DNA binding site [nucleotide binding]
745310000446	Transposase; Region: HTH_Tnp_1; pfam01527
745310000447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
745310000448	Helix-turn-helix domain; Region: HTH_28; pfam13518
745310000449	Homeodomain-like domain; Region: HTH_32; pfam13565
745310000450	Integrase core domain; Region: rve; pfam00665
745310000451	Transposase; Region: HTH_Tnp_1; pfam01527
745310000452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
745310000453	Helix-turn-helix domain; Region: HTH_28; pfam13518
745310000454	putative transposase OrfB; Reviewed; Region: PHA02517
745310000455	Homeodomain-like domain; Region: HTH_32; pfam13565
745310000456	Integrase core domain; Region: rve; pfam00665
745310000457	Integrase core domain; Region: rve_3; pfam13683
745310000458	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
745310000459	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
745310000460	Cl- selectivity filter; other site
745310000461	Cl- binding residues [ion binding]; other site
745310000462	pore gating glutamate residue; other site
745310000463	dimer interface [polypeptide binding]; other site
745310000464	FOG: CBS domain [General function prediction only]; Region: COG0517
745310000465	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
745310000466	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310000467	MarR family; Region: MarR_2; pfam12802
745310000468	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
745310000469	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
745310000470	homodimer interface [polypeptide binding]; other site
745310000471	substrate-cofactor binding pocket; other site
745310000472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310000473	catalytic residue [active]
745310000474	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310000475	HTH-like domain; Region: HTH_21; pfam13276
745310000476	Integrase core domain; Region: rve; pfam00665
745310000477	Transposase; Region: HTH_Tnp_1; pfam01527
745310000478	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
745310000479	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
745310000480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310000481	Integrase core domain; Region: rve; pfam00665
745310000482	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310000483	Walker A motif; other site
745310000484	ATP binding site [chemical binding]; other site
745310000485	Walker B motif; other site
745310000486	Transcriptional regulator; Region: Rrf2; cl17282
745310000487	Predicted transcriptional regulator [Transcription]; Region: COG1959
745310000488	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
745310000489	apolar tunnel; other site
745310000490	heme binding site [chemical binding]; other site
745310000491	dimerization interface [polypeptide binding]; other site
745310000492	Domain of unknown function (DUF1971); Region: DUF1971; pfam09313
745310000493	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
745310000494	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
745310000495	heme-binding site [chemical binding]; other site
745310000496	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
745310000497	FAD binding pocket [chemical binding]; other site
745310000498	FAD binding motif [chemical binding]; other site
745310000499	phosphate binding motif [ion binding]; other site
745310000500	beta-alpha-beta structure motif; other site
745310000501	NAD binding pocket [chemical binding]; other site
745310000502	Heme binding  pocket [chemical binding]; other site
745310000503	Predicted integral membrane protein [Function unknown]; Region: COG5615
745310000504	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
745310000505	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
745310000506	META domain; Region: META; pfam03724
745310000507	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
745310000508	Low-spin heme binding site [chemical binding]; other site
745310000509	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
745310000510	Putative water exit pathway; other site
745310000511	Binuclear center (active site) [active]
745310000512	Putative proton exit pathway; other site
745310000513	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
745310000514	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
745310000515	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
745310000516	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
745310000517	Cytochrome c; Region: Cytochrom_C; pfam00034
745310000518	Cytochrome c; Region: Cytochrom_C; pfam00034
745310000519	Predicted integral membrane protein [Function unknown]; Region: COG5473
745310000520	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
745310000521	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000522	metal-binding site [ion binding]
745310000523	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310000524	Soluble P-type ATPase [General function prediction only]; Region: COG4087
745310000525	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
745310000526	O-succinylhomoserine (thiol)-lyase; Region: O_succ_thio_ly; TIGR02080
745310000527	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
745310000528	homodimer interface [polypeptide binding]; other site
745310000529	substrate-cofactor binding pocket; other site
745310000530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310000531	catalytic residue [active]
745310000532	Autoinducer binding domain; Region: Autoind_bind; pfam03472
745310000533	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
745310000534	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310000535	DNA binding residues [nucleotide binding]
745310000536	dimerization interface [polypeptide binding]; other site
745310000537	transcriptional regulator TraR; Provisional; Region: PRK13870
745310000538	Autoinducer binding domain; Region: Autoind_bind; pfam03472
745310000539	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310000540	DNA binding residues [nucleotide binding]
745310000541	dimerization interface [polypeptide binding]; other site
745310000542	Autoinducer synthetase; Region: Autoind_synth; cl17404
745310000543	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
745310000544	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310000545	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310000546	catalytic residue [active]
745310000547	TrbC/VIRB2 family; Region: TrbC; pfam04956
745310000548	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
745310000549	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
745310000550	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
745310000551	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
745310000552	Type IV secretion system proteins; Region: T4SS; pfam07996
745310000553	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
745310000554	Type IV secretory pathway, component VirB8 [Intracellular trafficking and secretion]; Region: VirB8; COG3736
745310000555	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
745310000556	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
745310000557	VirB7 interaction site; other site
745310000558	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
745310000559	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
745310000560	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
745310000561	Walker A motif; other site
745310000562	hexamer interface [polypeptide binding]; other site
745310000563	ATP binding site [chemical binding]; other site
745310000564	Walker B motif; other site
745310000565	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
745310000566	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310000567	Walker A motif; other site
745310000568	ATP binding site [chemical binding]; other site
745310000569	Walker B motif; other site
745310000570	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
745310000571	WYL domain; Region: WYL; pfam13280
745310000572	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
745310000573	RNase_H superfamily; Region: RNase_H_2; pfam13482
745310000574	Part of AAA domain; Region: AAA_19; pfam13245
745310000575	AAA domain; Region: AAA_11; pfam13086
745310000576	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
745310000577	AAA domain; Region: AAA_12; pfam13087
745310000578	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
745310000579	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
745310000580	active site
745310000581	metal binding site [ion binding]; metal-binding site
745310000582	DNA binding site [nucleotide binding]
745310000583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310000584	AAA domain; Region: AAA_23; pfam13476
745310000585	Walker A/P-loop; other site
745310000586	ATP binding site [chemical binding]; other site
745310000587	DEAD-like helicases superfamily; Region: DEXDc; smart00487
745310000588	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310000589	ATP binding site [chemical binding]; other site
745310000590	putative Mg++ binding site [ion binding]; other site
745310000591	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
745310000592	DEAD-like helicases superfamily; Region: DEXDc; smart00487
745310000593	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310000594	ATP binding site [chemical binding]; other site
745310000595	putative Mg++ binding site [ion binding]; other site
745310000596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310000597	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
745310000598	nucleotide binding region [chemical binding]; other site
745310000599	ATP-binding site [chemical binding]; other site
745310000600	Methyltransferase domain; Region: Methyltransf_26; pfam13659
745310000601	HNH endonuclease; Region: HNH_2; pfam13391
745310000602	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
745310000603	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
745310000604	active site
745310000605	DNA binding site [nucleotide binding]
745310000606	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
745310000607	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
745310000608	Catalytic site [active]
745310000609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310000610	non-specific DNA binding site [nucleotide binding]; other site
745310000611	salt bridge; other site
745310000612	sequence-specific DNA binding site [nucleotide binding]; other site
745310000613	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310000614	Uncharacterized conserved protein [Function unknown]; Region: COG1479
745310000615	Protein of unknown function DUF262; Region: DUF262; pfam03235
745310000616	Uncharacterized conserved protein [Function unknown]; Region: COG3472
745310000617	Transposase domain (DUF772); Region: DUF772; pfam05598
745310000618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310000619	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
745310000620	Abi-like protein; Region: Abi_2; pfam07751
745310000621	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
745310000622	ParB-like nuclease domain; Region: ParB; smart00470
745310000623	KorB domain; Region: KorB; pfam08535
745310000624	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
745310000625	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
745310000626	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
745310000627	transmembrane helices; other site
745310000628	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
745310000629	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310000630	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310000631	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310000632	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
745310000633	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310000634	DNA binding site [nucleotide binding]
745310000635	active site
745310000636	Int/Topo IB signature motif; other site
745310000637	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310000638	potential frameshift: common BLAST hit: gi|347430659|ref|YP_004831267.1| ParB-like protein
745310000639	Helicase_C-like; Region: Helicase_C_4; pfam13871
745310000640	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
745310000641	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
745310000642	Int/Topo IB signature motif; other site
745310000643	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310000644	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
745310000645	active site
745310000646	DNA binding site [nucleotide binding]
745310000647	Int/Topo IB signature motif; other site
745310000648	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
745310000649	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
745310000650	Int/Topo IB signature motif; other site
745310000651	Replication initiator protein A; Region: RPA; pfam10134
745310000652	ParA-like protein; Provisional; Region: PHA02518
745310000653	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310000654	P-loop; other site
745310000655	Magnesium ion binding site [ion binding]; other site
745310000656	SprT-like family; Region: SprT-like; pfam10263
745310000657	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
745310000658	Helix-turn-helix domain; Region: HTH_37; pfam13744
745310000659	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
745310000660	catalytic core [active]
745310000661	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310000662	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
745310000663	DNA-binding interface [nucleotide binding]; DNA binding site
745310000664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310000665	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310000666	Integrase core domain; Region: rve; pfam00665
745310000667	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
745310000668	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
745310000669	Fic family protein [Function unknown]; Region: COG3177
745310000670	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
745310000671	Fic/DOC family; Region: Fic; pfam02661
745310000672	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
745310000673	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
745310000674	GIY-YIG motif/motif A; other site
745310000675	putative active site [active]
745310000676	putative metal binding site [ion binding]; other site
745310000677	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310000678	Ligand Binding Site [chemical binding]; other site
745310000679	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310000680	MarR family; Region: MarR_2; pfam12802
745310000681	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
745310000682	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
745310000683	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
745310000684	putative active site [active]
745310000685	putative metal binding site [ion binding]; other site
745310000686	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
745310000687	putative catalytic site [active]
745310000688	putative phosphate binding site [ion binding]; other site
745310000689	putative metal binding site [ion binding]; other site
745310000690	Uncharacterized conserved protein [Function unknown]; Region: COG3025
745310000691	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
745310000692	putative active site [active]
745310000693	putative metal binding residues [ion binding]; other site
745310000694	signature motif; other site
745310000695	putative triphosphate binding site [ion binding]; other site
745310000696	CHAD domain; Region: CHAD; pfam05235
745310000697	PIN domain; Region: PIN_3; cl17397
745310000698	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
745310000699	active site
745310000700	catalytic site [active]
745310000701	substrate binding site [chemical binding]; other site
745310000702	hypothetical protein; Provisional; Region: PRK06132
745310000703	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
745310000704	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
745310000705	Putative glucoamylase; Region: Glycoamylase; pfam10091
745310000706	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
745310000707	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
745310000708	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
745310000709	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310000710	Ligand Binding Site [chemical binding]; other site
745310000711	phosphoenolpyruvate synthase; Validated; Region: PRK06464
745310000712	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
745310000713	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
745310000714	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
745310000715	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310000716	Ligand Binding Site [chemical binding]; other site
745310000717	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310000718	Ligand Binding Site [chemical binding]; other site
745310000719	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310000720	non-specific DNA binding site [nucleotide binding]; other site
745310000721	salt bridge; other site
745310000722	sequence-specific DNA binding site [nucleotide binding]; other site
745310000723	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000724	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000725	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000726	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000727	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000728	catalytic residues [active]
745310000729	catalytic nucleophile [active]
745310000730	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000731	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000732	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000733	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000734	DNA binding site [nucleotide binding]
745310000735	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310000736	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310000737	Integrase core domain; Region: rve; pfam00665
745310000738	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
745310000739	active site
745310000740	NTP binding site [chemical binding]; other site
745310000741	metal binding triad [ion binding]; metal-binding site
745310000742	antibiotic binding site [chemical binding]; other site
745310000743	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
745310000744	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
745310000745	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
745310000746	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310000747	Walker A motif; other site
745310000748	ATP binding site [chemical binding]; other site
745310000749	Walker B motif; other site
745310000750	Integrase core domain; Region: rve; pfam00665
745310000751	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310000752	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000753	catalytic residues [active]
745310000754	catalytic nucleophile [active]
745310000755	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000756	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000757	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000758	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000759	DNA binding site [nucleotide binding]
745310000760	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000761	DNA-binding interface [nucleotide binding]; DNA binding site
745310000762	potential frameshift: common BLAST hit: gi|294010537|ref|YP_003543997.1| Tn3-family transposase
745310000763	potential protein location (hypothetical protein) that overlaps protein (Transposase)
745310000764	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000765	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000766	catalytic residues [active]
745310000767	catalytic nucleophile [active]
745310000768	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000769	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000770	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000771	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000772	DNA binding site [nucleotide binding]
745310000773	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000774	DNA-binding interface [nucleotide binding]; DNA binding site
745310000775	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
745310000776	hydrophobic ligand binding site; other site
745310000777	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310000778	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
745310000779	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310000780	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310000781	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310000782	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310000783	The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459
745310000784	substrate binding pocket [chemical binding]; other site
745310000785	dimerization interface [polypeptide binding]; other site
745310000786	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
745310000787	Zn binding site [ion binding]; other site
745310000788	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
745310000789	Zn binding site [ion binding]; other site
745310000790	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
745310000791	TAP-like protein; Region: Abhydrolase_4; pfam08386
745310000792	Predicted esterase [General function prediction only]; Region: COG0400
745310000793	putative hydrolase; Provisional; Region: PRK11460
745310000794	YCII-related domain; Region: YCII; cl00999
745310000795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
745310000796	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
745310000797	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310000798	C-terminal domain interface [polypeptide binding]; other site
745310000799	GSH binding site (G-site) [chemical binding]; other site
745310000800	dimer interface [polypeptide binding]; other site
745310000801	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
745310000802	N-terminal domain interface [polypeptide binding]; other site
745310000803	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310000804	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310000805	Integrase core domain; Region: rve; pfam00665
745310000806	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310000807	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310000808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310000809	NAD(P) binding site [chemical binding]; other site
745310000810	active site
745310000811	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
745310000812	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310000813	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
745310000814	substrate binding site [chemical binding]; other site
745310000815	dimerization interface [polypeptide binding]; other site
745310000816	active site
745310000817	calcium binding site [ion binding]; other site
745310000818	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
745310000819	AAA domain; Region: AAA_30; pfam13604
745310000820	Family description; Region: UvrD_C_2; pfam13538
745310000821	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310000822	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310000823	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000824	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000825	catalytic residues [active]
745310000826	catalytic nucleophile [active]
745310000827	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000828	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000829	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000830	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000831	DNA binding site [nucleotide binding]
745310000832	MobA/MobL family; Region: MobA_MobL; pfam03389
745310000833	AAA domain; Region: AAA_30; pfam13604
745310000834	Conjugal transfer protein TraD; Region: TraD; pfam06412
745310000835	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
745310000836	active site
745310000837	NTP binding site [chemical binding]; other site
745310000838	metal binding triad [ion binding]; metal-binding site
745310000839	antibiotic binding site [chemical binding]; other site
745310000840	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
745310000841	VbhA antitoxin and related proteins; Region: VbhA_like; cd11586
745310000842	FIC domain binding interface [polypeptide binding]; other site
745310000843	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
745310000844	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310000845	Walker A motif; other site
745310000846	ATP binding site [chemical binding]; other site
745310000847	Walker B motif; other site
745310000848	Replication initiator protein A; Region: RPA; pfam10134
745310000849	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310000850	ParA-like protein; Provisional; Region: PHA02518
745310000851	P-loop; other site
745310000852	Magnesium ion binding site [ion binding]; other site
745310000853	SprT-like family; Region: SprT-like; pfam10263
745310000854	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
745310000855	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
745310000856	Helix-turn-helix domain; Region: HTH_37; pfam13744
745310000857	Helix-turn-helix; Region: HTH_3; pfam01381
745310000858	salt bridge; other site
745310000859	non-specific DNA binding site [nucleotide binding]; other site
745310000860	sequence-specific DNA binding site [nucleotide binding]; other site
745310000861	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
745310000862	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310000863	Walker A motif; other site
745310000864	ATP binding site [chemical binding]; other site
745310000865	Walker B motif; other site
745310000866	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
745310000867	putative deacylase active site [active]
745310000868	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310000869	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310000870	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310000871	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310000872	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310000873	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310000874	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
745310000875	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310000876	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000877	metal-binding site [ion binding]
745310000878	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000879	metal-binding site [ion binding]
745310000880	Domain of unknown function (DUF305); Region: DUF305; cl17794
745310000881	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
745310000882	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310000883	DNA binding residues [nucleotide binding]
745310000884	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310000885	catalytic loop [active]
745310000886	iron binding site [ion binding]; other site
745310000887	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
745310000888	catalytic residues [active]
745310000889	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
745310000890	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
745310000891	DNA binding residues [nucleotide binding]
745310000892	dimer interface [polypeptide binding]; other site
745310000893	copper binding site [ion binding]; other site
745310000894	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000895	metal-binding site [ion binding]
745310000896	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
745310000897	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
745310000898	metal-binding site [ion binding]
745310000899	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310000900	Soluble P-type ATPase [General function prediction only]; Region: COG4087
745310000901	Transposase; Region: HTH_Tnp_1; pfam01527
745310000902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
745310000903	Helix-turn-helix domain; Region: HTH_28; pfam13518
745310000904	putative transposase OrfB; Reviewed; Region: PHA02517
745310000905	Homeodomain-like domain; Region: HTH_32; pfam13565
745310000906	Integrase core domain; Region: rve; pfam00665
745310000907	Integrase core domain; Region: rve_3; pfam13683
745310000908	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
745310000909	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
745310000910	minor groove reading motif; other site
745310000911	helix-hairpin-helix signature motif; other site
745310000912	substrate binding pocket [chemical binding]; other site
745310000913	active site
745310000914	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
745310000915	dihydrodipicolinate reductase; Provisional; Region: PRK00048
745310000916	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
745310000917	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
745310000918	Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998
745310000919	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
745310000920	GIY-YIG motif/motif A; other site
745310000921	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
745310000922	elongation factor P; Validated; Region: PRK00529
745310000923	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
745310000924	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
745310000925	RNA binding site [nucleotide binding]; other site
745310000926	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
745310000927	RNA binding site [nucleotide binding]; other site
745310000928	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
745310000929	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
745310000930	active site
745310000931	dimerization interface [polypeptide binding]; other site
745310000932	Uncharacterized conserved protein [Function unknown]; Region: COG3391
745310000933	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
745310000934	NADH dehydrogenase subunit B; Validated; Region: PRK06411
745310000935	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
745310000936	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
745310000937	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
745310000938	NADH dehydrogenase subunit D; Validated; Region: PRK06075
745310000939	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310000940	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
745310000941	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
745310000942	putative dimer interface [polypeptide binding]; other site
745310000943	[2Fe-2S] cluster binding site [ion binding]; other site
745310000944	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
745310000945	SLBB domain; Region: SLBB; pfam10531
745310000946	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
745310000947	NADH dehydrogenase subunit G; Validated; Region: PRK09130
745310000948	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310000949	catalytic loop [active]
745310000950	iron binding site [ion binding]; other site
745310000951	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
745310000952	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
745310000953	molybdopterin cofactor binding site; other site
745310000954	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
745310000955	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
745310000956	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
745310000957	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
745310000958	4Fe-4S binding domain; Region: Fer4; pfam00037
745310000959	4Fe-4S binding domain; Region: Fer4; pfam00037
745310000960	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
745310000961	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
745310000962	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
745310000963	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
745310000964	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
745310000965	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
745310000966	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
745310000967	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
745310000968	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
745310000969	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
745310000970	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
745310000971	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
745310000972	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
745310000973	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
745310000974	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
745310000975	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
745310000976	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
745310000977	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
745310000978	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
745310000979	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
745310000980	dimerization interface [polypeptide binding]; other site
745310000981	ligand binding site [chemical binding]; other site
745310000982	NADP binding site [chemical binding]; other site
745310000983	catalytic site [active]
745310000984	Bacterial SH3 domain; Region: SH3_4; pfam06347
745310000985	Bacterial SH3 domain; Region: SH3_4; pfam06347
745310000986	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310000987	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310000988	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310000989	catalytic residues [active]
745310000990	catalytic nucleophile [active]
745310000991	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310000992	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310000993	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310000994	Synaptic Site I dimer interface [polypeptide binding]; other site
745310000995	DNA binding site [nucleotide binding]
745310000996	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310000997	DNA-binding interface [nucleotide binding]; DNA binding site
745310000998	potential frameshift: common BLAST hit: gi|410687270|ref|YP_006965784.1| Transposase
745310000999	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310001000	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310001001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310001002	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
745310001003	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
745310001004	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
745310001005	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
745310001006	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
745310001007	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
745310001008	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
745310001009	type II secretion system protein E; Region: type_II_gspE; TIGR02533
745310001010	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
745310001011	Walker A motif; other site
745310001012	ATP binding site [chemical binding]; other site
745310001013	Walker B motif; other site
745310001014	type II secretion system protein F; Region: GspF; TIGR02120
745310001015	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
745310001016	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
745310001017	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
745310001018	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
745310001019	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
745310001020	type II secretion system protein I; Region: gspI; TIGR01707
745310001021	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
745310001022	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
745310001023	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
745310001024	type II secretion system protein J; Region: gspJ; TIGR01711
745310001025	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
745310001026	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
745310001027	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
745310001028	GspL periplasmic domain; Region: GspL_C; cl14909
745310001029	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
745310001030	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
745310001031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310001032	putative substrate translocation pore; other site
745310001033	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
745310001034	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
745310001035	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310001036	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310001037	N-terminal plug; other site
745310001038	ligand-binding site [chemical binding]; other site
745310001039	PEP-CTERM motif; Region: VPEP; pfam07589
745310001040	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310001041	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310001042	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
745310001043	active site
745310001044	catalytic residues [active]
745310001045	metal binding site [ion binding]; metal-binding site
745310001046	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
745310001047	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
745310001048	hypothetical protein; Provisional; Region: PRK14812
745310001049	substrate binding site [chemical binding]; other site
745310001050	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
745310001051	substrate binding site [chemical binding]; other site
745310001052	ligand binding site [chemical binding]; other site
745310001053	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
745310001054	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
745310001055	Isochorismatase family; Region: Isochorismatase; pfam00857
745310001056	catalytic triad [active]
745310001057	conserved cis-peptide bond; other site
745310001058	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
745310001059	putative active site [active]
745310001060	putative catalytic site [active]
745310001061	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
745310001062	putative active site [active]
745310001063	putative catalytic site [active]
745310001064	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310001065	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
745310001066	NAD(P) binding site [chemical binding]; other site
745310001067	catalytic residues [active]
745310001068	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310001069	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
745310001070	active site
745310001071	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
745310001072	Methyltransferase domain; Region: Methyltransf_31; pfam13847
745310001073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310001074	S-adenosylmethionine binding site [chemical binding]; other site
745310001075	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
745310001076	Predicted amidohydrolase [General function prediction only]; Region: COG0388
745310001077	active site
745310001078	catalytic triad [active]
745310001079	dimer interface [polypeptide binding]; other site
745310001080	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
745310001081	FAD binding domain; Region: FAD_binding_4; pfam01565
745310001082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310001083	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310001084	putative substrate translocation pore; other site
745310001085	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310001086	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310001087	N-terminal plug; other site
745310001088	ligand-binding site [chemical binding]; other site
745310001089	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
745310001090	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
745310001091	putative active site [active]
745310001092	putative catalytic site [active]
745310001093	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310001094	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310001095	active site
745310001096	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310001097	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310001098	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310001099	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310001100	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
745310001101	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310001102	DNA-binding site [nucleotide binding]; DNA binding site
745310001103	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
745310001104	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
745310001105	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
745310001106	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
745310001107	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310001108	acyl-activating enzyme (AAE) consensus motif; other site
745310001109	active site
745310001110	AMP binding site [chemical binding]; other site
745310001111	CoA binding site [chemical binding]; other site
745310001112	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
745310001113	Amidase; Region: Amidase; cl11426
745310001114	REDY-like protein HapK; Region: HapK; pfam11639
745310001115	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310001116	classical (c) SDRs; Region: SDR_c; cd05233
745310001117	NAD(P) binding site [chemical binding]; other site
745310001118	active site
745310001119	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
745310001120	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
745310001121	enoyl-CoA hydratase; Provisional; Region: PRK06127
745310001122	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310001123	substrate binding site [chemical binding]; other site
745310001124	oxyanion hole (OAH) forming residues; other site
745310001125	trimer interface [polypeptide binding]; other site
745310001126	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
745310001127	active site
745310001128	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
745310001129	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
745310001130	NADP binding site [chemical binding]; other site
745310001131	dimer interface [polypeptide binding]; other site
745310001132	YCII-related domain; Region: YCII; cl00999
745310001133	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
745310001134	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310001135	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310001136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310001137	Integrase core domain; Region: rve; pfam00665
745310001138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310001139	Walker A motif; other site
745310001140	ATP binding site [chemical binding]; other site
745310001141	Walker B motif; other site
745310001142	Transglycosylase SLT domain; Region: SLT_2; pfam13406
745310001143	murein hydrolase B; Provisional; Region: PRK10760; cl17906
745310001144	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
745310001145	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
745310001146	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
745310001147	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
745310001148	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
745310001149	thymidylate kinase; Validated; Region: tmk; PRK00698
745310001150	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
745310001151	TMP-binding site; other site
745310001152	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
745310001153	DNA polymerase III subunit delta'; Validated; Region: PRK08485
745310001154	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
745310001155	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
745310001156	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
745310001157	active site
745310001158	HIGH motif; other site
745310001159	KMSKS motif; other site
745310001160	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
745310001161	tRNA binding surface [nucleotide binding]; other site
745310001162	anticodon binding site; other site
745310001163	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
745310001164	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
745310001165	active site
745310001166	putative hydrolase; Provisional; Region: PRK02113
745310001167	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
745310001168	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
745310001169	catalytic motif [active]
745310001170	Catalytic residue [active]
745310001171	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
745310001172	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
745310001173	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
745310001174	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
745310001175	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
745310001176	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310001177	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
745310001178	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310001179	DNA binding residues [nucleotide binding]
745310001180	DNA primase, catalytic core; Region: dnaG; TIGR01391
745310001181	CHC2 zinc finger; Region: zf-CHC2; pfam01807
745310001182	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
745310001183	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
745310001184	active site
745310001185	metal binding site [ion binding]; metal-binding site
745310001186	interdomain interaction site; other site
745310001187	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
745310001188	GIY-YIG motif/motif A; other site
745310001189	putative active site [active]
745310001190	putative metal binding site [ion binding]; other site
745310001191	Yqey-like protein; Region: YqeY; pfam09424
745310001192	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
745310001193	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
745310001194	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
745310001195	catalytic site [active]
745310001196	subunit interface [polypeptide binding]; other site
745310001197	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
745310001198	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
745310001199	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310001200	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
745310001201	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
745310001202	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310001203	ATP-grasp domain; Region: ATP-grasp_4; cl17255
745310001204	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
745310001205	IMP binding site; other site
745310001206	dimer interface [polypeptide binding]; other site
745310001207	partial ornithine binding site; other site
745310001208	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
745310001209	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
745310001210	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
745310001211	Rhomboid family; Region: Rhomboid; cl11446
745310001212	dihydroorotase; Validated; Region: pyrC; PRK09357
745310001213	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
745310001214	active site
745310001215	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
745310001216	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
745310001217	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
745310001218	Transglycosylase; Region: Transgly; pfam00912
745310001219	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
745310001220	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
745310001221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4805
745310001222	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310001223	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310001224	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
745310001225	putative NAD(P) binding site [chemical binding]; other site
745310001226	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
745310001227	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
745310001228	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
745310001229	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
745310001230	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
745310001231	carboxyltransferase (CT) interaction site; other site
745310001232	biotinylation site [posttranslational modification]; other site
745310001233	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
745310001234	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310001235	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
745310001236	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
745310001237	isovaleryl-CoA dehydrogenase; Region: PLN02519
745310001238	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310001239	active site
745310001240	short chain dehydrogenase; Provisional; Region: PRK07677
745310001241	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310001242	NAD(P) binding site [chemical binding]; other site
745310001243	active site
745310001244	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
745310001245	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310001246	putative DNA binding site [nucleotide binding]; other site
745310001247	putative Zn2+ binding site [ion binding]; other site
745310001248	AsnC family; Region: AsnC_trans_reg; pfam01037
745310001249	Helix-turn-helix domain; Region: HTH_18; pfam12833
745310001250	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310001251	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310001252	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310001253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310001254	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310001255	classical (c) SDRs; Region: SDR_c; cd05233
745310001256	NAD(P) binding site [chemical binding]; other site
745310001257	active site
745310001258	EthD domain; Region: EthD; pfam07110
745310001259	Rrf2 family protein; Region: rrf2_super; TIGR00738
745310001260	Transcriptional regulator; Region: Rrf2; pfam02082
745310001261	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
745310001262	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
745310001263	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
745310001264	NAD(P) binding pocket [chemical binding]; other site
745310001265	Nidogen-like; Region: NIDO; cl02648
745310001266	PEP-CTERM motif; Region: VPEP; pfam07589
745310001267	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
745310001268	EamA-like transporter family; Region: EamA; pfam00892
745310001269	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
745310001270	CcmE; Region: CcmE; pfam03100
745310001271	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
745310001272	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
745310001273	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
745310001274	catalytic residues [active]
745310001275	central insert; other site
745310001276	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
745310001277	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
745310001278	TPR motif; other site
745310001279	binding surface
745310001280	TPR repeat; Region: TPR_11; pfam13414
745310001281	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
745310001282	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
745310001283	hexamer interface [polypeptide binding]; other site
745310001284	ligand binding site [chemical binding]; other site
745310001285	putative active site [active]
745310001286	NAD(P) binding site [chemical binding]; other site
745310001287	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
745310001288	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
745310001289	putative DNA binding site [nucleotide binding]; other site
745310001290	putative Zn2+ binding site [ion binding]; other site
745310001291	AsnC family; Region: AsnC_trans_reg; pfam01037
745310001292	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
745310001293	potassium uptake protein; Region: kup; TIGR00794
745310001294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310001295	metal binding site [ion binding]; metal-binding site
745310001296	active site
745310001297	I-site; other site
745310001298	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310001299	signal recognition particle protein; Provisional; Region: PRK10867
745310001300	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
745310001301	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
745310001302	P loop; other site
745310001303	GTP binding site [chemical binding]; other site
745310001304	Signal peptide binding domain; Region: SRP_SPB; pfam02978
745310001305	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
745310001306	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
745310001307	RimM N-terminal domain; Region: RimM; pfam01782
745310001308	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
745310001309	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
745310001310	oligomeric interface; other site
745310001311	putative active site [active]
745310001312	homodimer interface [polypeptide binding]; other site
745310001313	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
745310001314	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
745310001315	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
745310001316	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310001317	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310001318	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
745310001319	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
745310001320	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
745310001321	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310001322	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
745310001323	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310001324	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
745310001325	active site
745310001326	Zn binding site [ion binding]; other site
745310001327	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
745310001328	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
745310001329	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
745310001330	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310001331	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310001332	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310001333	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310001334	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310001335	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310001336	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
745310001337	Autotransporter beta-domain; Region: Autotransporter; pfam03797
745310001338	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310001339	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310001340	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
745310001341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310001342	dimerization interface [polypeptide binding]; other site
745310001343	putative DNA binding site [nucleotide binding]; other site
745310001344	putative Zn2+ binding site [ion binding]; other site
745310001345	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
745310001346	putative hydrophobic ligand binding site [chemical binding]; other site
745310001347	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
745310001348	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
745310001349	Uncharacterized conserved protein [Function unknown]; Region: COG2128
745310001350	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
745310001351	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310001352	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
745310001353	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
745310001354	Domain of unknown function (DUF336); Region: DUF336; pfam03928
745310001355	short chain dehydrogenase; Provisional; Region: PRK09291
745310001356	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310001357	NADP binding site [chemical binding]; other site
745310001358	active site
745310001359	steroid binding site; other site
745310001360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310001361	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310001362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310001363	short chain dehydrogenase; Provisional; Region: PRK06180
745310001364	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310001365	NADP binding site [chemical binding]; other site
745310001366	active site
745310001367	steroid binding site; other site
745310001368	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
745310001369	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
745310001370	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310001371	active site
745310001372	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
745310001373	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
745310001374	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
745310001375	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
745310001376	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310001377	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
745310001378	substrate binding site [chemical binding]; other site
745310001379	oxyanion hole (OAH) forming residues; other site
745310001380	trimer interface [polypeptide binding]; other site
745310001381	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310001382	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
745310001383	dimer interface [polypeptide binding]; other site
745310001384	active site
745310001385	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
745310001386	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
745310001387	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
745310001388	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
745310001389	acyl-activating enzyme (AAE) consensus motif; other site
745310001390	putative active site [active]
745310001391	putative AMP binding site [chemical binding]; other site
745310001392	putative CoA binding site [chemical binding]; other site
745310001393	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
745310001394	DNA binding residues [nucleotide binding]
745310001395	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
745310001396	putative dimer interface [polypeptide binding]; other site
745310001397	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
745310001398	classical (c) SDRs; Region: SDR_c; cd05233
745310001399	NAD(P) binding site [chemical binding]; other site
745310001400	active site
745310001401	classical (c) SDRs; Region: SDR_c; cd05233
745310001402	NAD(P) binding site [chemical binding]; other site
745310001403	active site
745310001404	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
745310001405	active site
745310001406	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
745310001407	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
745310001408	NodB motif; other site
745310001409	putative active site [active]
745310001410	putative catalytic site [active]
745310001411	putative Zn binding site [ion binding]; other site
745310001412	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
745310001413	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
745310001414	DXD motif; other site
745310001415	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
745310001416	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
745310001417	Predicted integral membrane protein [Function unknown]; Region: COG0392
745310001418	Uncharacterized conserved protein [Function unknown]; Region: COG2898
745310001419	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
745310001420	Cation efflux family; Region: Cation_efflux; pfam01545
745310001421	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310001422	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
745310001423	PA/protease or protease-like domain interface [polypeptide binding]; other site
745310001424	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
745310001425	Peptidase family M28; Region: Peptidase_M28; pfam04389
745310001426	metal binding site [ion binding]; metal-binding site
745310001427	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
745310001428	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310001429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310001430	ABC transporter; Region: ABC_tran_2; pfam12848
745310001431	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310001432	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
745310001433	active site clefts [active]
745310001434	zinc binding site [ion binding]; other site
745310001435	dimer interface [polypeptide binding]; other site
745310001436	lipoyl synthase; Provisional; Region: PRK05481
745310001437	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310001438	FeS/SAM binding site; other site
745310001439	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
745310001440	putative coenzyme Q binding site [chemical binding]; other site
745310001441	Competence-damaged protein; Region: CinA; pfam02464
745310001442	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
745310001443	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
745310001444	substrate binding site; other site
745310001445	dimer interface; other site
745310001446	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
745310001447	homotrimer interaction site [polypeptide binding]; other site
745310001448	zinc binding site [ion binding]; other site
745310001449	CDP-binding sites; other site
745310001450	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
745310001451	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
745310001452	FMN binding site [chemical binding]; other site
745310001453	active site
745310001454	catalytic residues [active]
745310001455	substrate binding site [chemical binding]; other site
745310001456	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
745310001457	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
745310001458	putative active site [active]
745310001459	heme pocket [chemical binding]; other site
745310001460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310001461	phosphorylation site [posttranslational modification]
745310001462	dimer interface [polypeptide binding]; other site
745310001463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310001464	ATP binding site [chemical binding]; other site
745310001465	Mg2+ binding site [ion binding]; other site
745310001466	G-X-G motif; other site
745310001467	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
745310001468	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001469	active site
745310001470	phosphorylation site [posttranslational modification]
745310001471	intermolecular recognition site; other site
745310001472	dimerization interface [polypeptide binding]; other site
745310001473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310001474	Walker A motif; other site
745310001475	ATP binding site [chemical binding]; other site
745310001476	Walker B motif; other site
745310001477	arginine finger; other site
745310001478	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
745310001479	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310001480	dimerization interface [polypeptide binding]; other site
745310001481	PAS domain; Region: PAS; smart00091
745310001482	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
745310001483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310001484	dimer interface [polypeptide binding]; other site
745310001485	phosphorylation site [posttranslational modification]
745310001486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310001487	ATP binding site [chemical binding]; other site
745310001488	Mg2+ binding site [ion binding]; other site
745310001489	G-X-G motif; other site
745310001490	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
745310001491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001492	active site
745310001493	phosphorylation site [posttranslational modification]
745310001494	intermolecular recognition site; other site
745310001495	dimerization interface [polypeptide binding]; other site
745310001496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310001497	Walker A motif; other site
745310001498	ATP binding site [chemical binding]; other site
745310001499	Walker B motif; other site
745310001500	arginine finger; other site
745310001501	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310001502	RNA-binding protein Hfq; Provisional; Region: PRK14091
745310001503	bacterial Hfq-like; Region: Hfq; cd01716
745310001504	hexamer interface [polypeptide binding]; other site
745310001505	Sm1 motif; other site
745310001506	RNA binding site [nucleotide binding]; other site
745310001507	Sm2 motif; other site
745310001508	bacterial Hfq-like; Region: Hfq; cd01716
745310001509	hexamer interface [polypeptide binding]; other site
745310001510	Sm1 motif; other site
745310001511	RNA binding site [nucleotide binding]; other site
745310001512	Sm2 motif; other site
745310001513	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
745310001514	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
745310001515	HflX GTPase family; Region: HflX; cd01878
745310001516	G1 box; other site
745310001517	GTP/Mg2+ binding site [chemical binding]; other site
745310001518	Switch I region; other site
745310001519	G2 box; other site
745310001520	G3 box; other site
745310001521	Switch II region; other site
745310001522	G4 box; other site
745310001523	G5 box; other site
745310001524	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
745310001525	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
745310001526	homodimer interface [polypeptide binding]; other site
745310001527	metal binding site [ion binding]; metal-binding site
745310001528	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
745310001529	homodimer interface [polypeptide binding]; other site
745310001530	active site
745310001531	putative chemical substrate binding site [chemical binding]; other site
745310001532	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
745310001533	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
745310001534	putative NAD(P) binding site [chemical binding]; other site
745310001535	putative substrate binding site [chemical binding]; other site
745310001536	catalytic Zn binding site [ion binding]; other site
745310001537	structural Zn binding site [ion binding]; other site
745310001538	dimer interface [polypeptide binding]; other site
745310001539	adenylosuccinate lyase; Provisional; Region: PRK07492
745310001540	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
745310001541	tetramer interface [polypeptide binding]; other site
745310001542	active site
745310001543	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
745310001544	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310001545	active site
745310001546	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
745310001547	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
745310001548	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
745310001549	methionine sulfoxide reductase A; Provisional; Region: PRK14054
745310001550	PAS fold; Region: PAS_4; pfam08448
745310001551	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
745310001552	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310001553	putative active site [active]
745310001554	heme pocket [chemical binding]; other site
745310001555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310001556	putative active site [active]
745310001557	heme pocket [chemical binding]; other site
745310001558	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310001559	dimer interface [polypeptide binding]; other site
745310001560	phosphorylation site [posttranslational modification]
745310001561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310001562	ATP binding site [chemical binding]; other site
745310001563	G-X-G motif; other site
745310001564	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
745310001565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001566	active site
745310001567	phosphorylation site [posttranslational modification]
745310001568	intermolecular recognition site; other site
745310001569	dimerization interface [polypeptide binding]; other site
745310001570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
745310001571	Guanylyl transferase CofC like; Region: CofC; cl17472
745310001572	FO synthase; Reviewed; Region: fbiC; PRK09234
745310001573	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310001574	FeS/SAM binding site; other site
745310001575	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
745310001576	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310001577	FeS/SAM binding site; other site
745310001578	glutathione reductase; Validated; Region: PRK06116
745310001579	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310001580	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310001581	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
745310001582	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
745310001583	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
745310001584	active site
745310001585	dimer interface [polypeptide binding]; other site
745310001586	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
745310001587	dimer interface [polypeptide binding]; other site
745310001588	active site
745310001589	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
745310001590	Catalytic site [active]
745310001591	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
745310001592	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
745310001593	PAS domain S-box; Region: sensory_box; TIGR00229
745310001594	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310001595	putative active site [active]
745310001596	heme pocket [chemical binding]; other site
745310001597	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310001598	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310001599	metal binding site [ion binding]; metal-binding site
745310001600	active site
745310001601	I-site; other site
745310001602	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
745310001603	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
745310001604	ATP binding site [chemical binding]; other site
745310001605	Mg++ binding site [ion binding]; other site
745310001606	motif III; other site
745310001607	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310001608	nucleotide binding region [chemical binding]; other site
745310001609	ATP-binding site [chemical binding]; other site
745310001610	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
745310001611	glutamate carboxypeptidase; Reviewed; Region: PRK06133
745310001612	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
745310001613	metal binding site [ion binding]; metal-binding site
745310001614	dimer interface [polypeptide binding]; other site
745310001615	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
745310001616	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
745310001617	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
745310001618	putative FMN binding site [chemical binding]; other site
745310001619	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
745310001620	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
745310001621	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310001622	Coenzyme A binding pocket [chemical binding]; other site
745310001623	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
745310001624	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
745310001625	metal binding site 2 [ion binding]; metal-binding site
745310001626	putative DNA binding helix; other site
745310001627	metal binding site 1 [ion binding]; metal-binding site
745310001628	dimer interface [polypeptide binding]; other site
745310001629	structural Zn2+ binding site [ion binding]; other site
745310001630	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
745310001631	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
745310001632	putative acyl-acceptor binding pocket; other site
745310001633	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
745310001634	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
745310001635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310001636	FeS/SAM binding site; other site
745310001637	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
745310001638	Cytochrome c; Region: Cytochrom_C; pfam00034
745310001639	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
745310001640	PhoH-like protein; Region: PhoH; pfam02562
745310001641	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
745310001642	FOG: CBS domain [General function prediction only]; Region: COG0517
745310001643	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
745310001644	Transporter associated domain; Region: CorC_HlyC; smart01091
745310001645	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
745310001646	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
745310001647	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
745310001648	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
745310001649	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310001650	putative metal binding site [ion binding]; other site
745310001651	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
745310001652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310001653	catalytic residue [active]
745310001654	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
745310001655	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
745310001656	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310001657	catalytic residue [active]
745310001658	Methyltransferase domain; Region: Methyltransf_31; pfam13847
745310001659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310001660	S-adenosylmethionine binding site [chemical binding]; other site
745310001661	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
745310001662	lipoyl attachment site [posttranslational modification]; other site
745310001663	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
745310001664	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
745310001665	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
745310001666	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
745310001667	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
745310001668	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
745310001669	putative active site [active]
745310001670	putative substrate binding site [chemical binding]; other site
745310001671	ATP binding site [chemical binding]; other site
745310001672	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
745310001673	RNA/DNA hybrid binding site [nucleotide binding]; other site
745310001674	active site
745310001675	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
745310001676	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
745310001677	hypothetical protein; Provisional; Region: PRK09133
745310001678	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
745310001679	putative metal binding site [ion binding]; other site
745310001680	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
745310001681	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
745310001682	RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678
745310001683	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
745310001684	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
745310001685	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
745310001686	dimer interface [polypeptide binding]; other site
745310001687	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
745310001688	active site
745310001689	Fe binding site [ion binding]; other site
745310001690	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310001691	MarR family; Region: MarR_2; pfam12802
745310001692	CHAT domain; Region: CHAT; pfam12770
745310001693	CHASE2 domain; Region: CHASE2; pfam05226
745310001694	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
745310001695	cyclase homology domain; Region: CHD; cd07302
745310001696	nucleotidyl binding site; other site
745310001697	metal binding site [ion binding]; metal-binding site
745310001698	dimer interface [polypeptide binding]; other site
745310001699	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
745310001700	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
745310001701	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
745310001702	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310001703	active site
745310001704	HIGH motif; other site
745310001705	nucleotide binding site [chemical binding]; other site
745310001706	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310001707	active site
745310001708	KMSKS motif; other site
745310001709	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
745310001710	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
745310001711	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310001712	NAD(P) binding site [chemical binding]; other site
745310001713	catalytic residues [active]
745310001714	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
745310001715	Domain of unknown function (DUF336); Region: DUF336; cl01249
745310001716	Domain of unknown function (DUF336); Region: DUF336; cl01249
745310001717	Domain of unknown function (DUF336); Region: DUF336; cl01249
745310001718	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
745310001719	LVIVD repeat; Region: LVIVD; pfam08309
745310001720	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310001721	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310001722	dimerization interface [polypeptide binding]; other site
745310001723	putative DNA binding site [nucleotide binding]; other site
745310001724	putative Zn2+ binding site [ion binding]; other site
745310001725	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
745310001726	NADH(P)-binding; Region: NAD_binding_10; pfam13460
745310001727	NAD binding site [chemical binding]; other site
745310001728	putative active site [active]
745310001729	substrate binding site [chemical binding]; other site
745310001730	HutD; Region: HutD; pfam05962
745310001731	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
745310001732	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
745310001733	glutaminase active site [active]
745310001734	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
745310001735	dimer interface [polypeptide binding]; other site
745310001736	active site
745310001737	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
745310001738	dimer interface [polypeptide binding]; other site
745310001739	active site
745310001740	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
745310001741	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
745310001742	Substrate binding site; other site
745310001743	Mg++ binding site; other site
745310001744	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
745310001745	active site
745310001746	substrate binding site [chemical binding]; other site
745310001747	CoA binding site [chemical binding]; other site
745310001748	phosphoglycolate phosphatase; Provisional; Region: PRK13222
745310001749	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310001750	motif II; other site
745310001751	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
745310001752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310001753	dimer interface [polypeptide binding]; other site
745310001754	phosphorylation site [posttranslational modification]
745310001755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310001756	ATP binding site [chemical binding]; other site
745310001757	Mg2+ binding site [ion binding]; other site
745310001758	G-X-G motif; other site
745310001759	PBP superfamily domain; Region: PBP_like_2; cl17296
745310001760	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
745310001761	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
745310001762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310001763	dimer interface [polypeptide binding]; other site
745310001764	conserved gate region; other site
745310001765	putative PBP binding loops; other site
745310001766	ABC-ATPase subunit interface; other site
745310001767	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
745310001768	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
745310001769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310001770	dimer interface [polypeptide binding]; other site
745310001771	conserved gate region; other site
745310001772	putative PBP binding loops; other site
745310001773	ABC-ATPase subunit interface; other site
745310001774	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
745310001775	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
745310001776	Walker A/P-loop; other site
745310001777	ATP binding site [chemical binding]; other site
745310001778	Q-loop/lid; other site
745310001779	ABC transporter signature motif; other site
745310001780	Walker B; other site
745310001781	D-loop; other site
745310001782	H-loop/switch region; other site
745310001783	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
745310001784	PhoU domain; Region: PhoU; pfam01895
745310001785	PhoU domain; Region: PhoU; pfam01895
745310001786	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
745310001787	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001788	active site
745310001789	phosphorylation site [posttranslational modification]
745310001790	intermolecular recognition site; other site
745310001791	dimerization interface [polypeptide binding]; other site
745310001792	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310001793	DNA binding site [nucleotide binding]
745310001794	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310001795	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
745310001796	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310001797	NAD(P) binding site [chemical binding]; other site
745310001798	active site
745310001799	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
745310001800	serine O-acetyltransferase; Region: cysE; TIGR01172
745310001801	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
745310001802	trimer interface [polypeptide binding]; other site
745310001803	active site
745310001804	substrate binding site [chemical binding]; other site
745310001805	CoA binding site [chemical binding]; other site
745310001806	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
745310001807	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
745310001808	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
745310001809	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
745310001810	dimer interface [polypeptide binding]; other site
745310001811	decamer (pentamer of dimers) interface [polypeptide binding]; other site
745310001812	catalytic triad [active]
745310001813	peroxidatic and resolving cysteines [active]
745310001814	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
745310001815	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310001816	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
745310001817	dimerization interface [polypeptide binding]; other site
745310001818	muropeptide transporter; Reviewed; Region: ampG; PRK11902
745310001819	muropeptide transporter; Validated; Region: ampG; cl17669
745310001820	Response regulator receiver domain; Region: Response_reg; pfam00072
745310001821	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001822	active site
745310001823	phosphorylation site [posttranslational modification]
745310001824	intermolecular recognition site; other site
745310001825	dimerization interface [polypeptide binding]; other site
745310001826	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
745310001827	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
745310001828	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
745310001829	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310001830	RNA binding surface [nucleotide binding]; other site
745310001831	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
745310001832	active site
745310001833	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
745310001834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310001835	S-adenosylmethionine binding site [chemical binding]; other site
745310001836	metabolite-proton symporter; Region: 2A0106; TIGR00883
745310001837	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
745310001838	amphipathic channel; other site
745310001839	Asn-Pro-Ala signature motifs; other site
745310001840	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
745310001841	Family description; Region: UvrD_C_2; pfam13538
745310001842	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
745310001843	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
745310001844	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310001845	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310001846	N-terminal plug; other site
745310001847	ligand-binding site [chemical binding]; other site
745310001848	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
745310001849	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310001850	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310001851	N-terminal plug; other site
745310001852	ligand-binding site [chemical binding]; other site
745310001853	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
745310001854	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
745310001855	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310001856	N-terminal domain interface [polypeptide binding]; other site
745310001857	dimer interface [polypeptide binding]; other site
745310001858	substrate binding pocket (H-site) [chemical binding]; other site
745310001859	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
745310001860	putative hydrophobic ligand binding site [chemical binding]; other site
745310001861	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
745310001862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310001863	DNA-binding site [nucleotide binding]; DNA binding site
745310001864	UTRA domain; Region: UTRA; pfam07702
745310001865	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
745310001866	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310001867	active site
745310001868	imidazolonepropionase; Validated; Region: PRK09356
745310001869	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
745310001870	active site
745310001871	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
745310001872	active sites [active]
745310001873	tetramer interface [polypeptide binding]; other site
745310001874	N-formylglutamate amidohydrolase; Region: FGase; cl01522
745310001875	urocanate hydratase; Provisional; Region: PRK05414
745310001876	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
745310001877	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
745310001878	TrkA-N domain; Region: TrkA_N; pfam02254
745310001879	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
745310001880	trimerization site [polypeptide binding]; other site
745310001881	active site
745310001882	Colicin V production protein; Region: Colicin_V; pfam02674
745310001883	DNA repair protein RadA; Provisional; Region: PRK11823
745310001884	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310001885	Walker A motif; other site
745310001886	ATP binding site [chemical binding]; other site
745310001887	Walker B motif; other site
745310001888	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
745310001889	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
745310001890	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
745310001891	E3 interaction surface; other site
745310001892	lipoyl attachment site [posttranslational modification]; other site
745310001893	e3 binding domain; Region: E3_binding; pfam02817
745310001894	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
745310001895	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
745310001896	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
745310001897	alpha subunit interface [polypeptide binding]; other site
745310001898	TPP binding site [chemical binding]; other site
745310001899	heterodimer interface [polypeptide binding]; other site
745310001900	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
745310001901	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
745310001902	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
745310001903	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
745310001904	tetramer interface [polypeptide binding]; other site
745310001905	TPP-binding site [chemical binding]; other site
745310001906	heterodimer interface [polypeptide binding]; other site
745310001907	phosphorylation loop region [posttranslational modification]
745310001908	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
745310001909	PEP-CTERM motif; Region: VPEP; pfam07589
745310001910	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310001911	dimerization interface [polypeptide binding]; other site
745310001912	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310001913	dimer interface [polypeptide binding]; other site
745310001914	phosphorylation site [posttranslational modification]
745310001915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310001916	ATP binding site [chemical binding]; other site
745310001917	Mg2+ binding site [ion binding]; other site
745310001918	G-X-G motif; other site
745310001919	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310001920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310001921	active site
745310001922	phosphorylation site [posttranslational modification]
745310001923	intermolecular recognition site; other site
745310001924	dimerization interface [polypeptide binding]; other site
745310001925	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310001926	DNA binding site [nucleotide binding]
745310001927	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
745310001928	EF-hand domain pair; Region: EF_hand_5; pfam13499
745310001929	Ca2+ binding site [ion binding]; other site
745310001930	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310001931	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
745310001932	FtsX-like permease family; Region: FtsX; pfam02687
745310001933	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
745310001934	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310001935	Walker A/P-loop; other site
745310001936	ATP binding site [chemical binding]; other site
745310001937	Q-loop/lid; other site
745310001938	ABC transporter signature motif; other site
745310001939	Walker B; other site
745310001940	D-loop; other site
745310001941	H-loop/switch region; other site
745310001942	macrolide transporter subunit MacA; Provisional; Region: PRK11578
745310001943	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310001944	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310001945	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310001946	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310001947	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310001948	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
745310001949	putative effector binding pocket; other site
745310001950	dimerization interface [polypeptide binding]; other site
745310001951	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
745310001952	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
745310001953	Pirin-related protein [General function prediction only]; Region: COG1741
745310001954	Pirin; Region: Pirin; pfam02678
745310001955	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
745310001956	YceG-like family; Region: YceG; pfam02618
745310001957	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
745310001958	dimerization interface [polypeptide binding]; other site
745310001959	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
745310001960	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
745310001961	dimer interface [polypeptide binding]; other site
745310001962	active site
745310001963	acyl carrier protein; Provisional; Region: acpP; PRK00982
745310001964	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
745310001965	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
745310001966	NAD(P) binding site [chemical binding]; other site
745310001967	homotetramer interface [polypeptide binding]; other site
745310001968	homodimer interface [polypeptide binding]; other site
745310001969	active site
745310001970	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
745310001971	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
745310001972	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
745310001973	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
745310001974	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
745310001975	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
745310001976	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
745310001977	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
745310001978	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
745310001979	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310001980	putative active site [active]
745310001981	heme pocket [chemical binding]; other site
745310001982	Predicted membrane protein [Function unknown]; Region: COG4655
745310001983	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
745310001984	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
745310001985	GTP cyclohydrolase I; Provisional; Region: PLN03044
745310001986	active site
745310001987	malate synthase G; Provisional; Region: PRK02999
745310001988	active site
745310001989	hypothetical protein; Provisional; Region: PRK07338
745310001990	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
745310001991	metal binding site [ion binding]; metal-binding site
745310001992	dimer interface [polypeptide binding]; other site
745310001993	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
745310001994	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
745310001995	succinylarginine dihydrolase; Provisional; Region: PRK13281
745310001996	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310001997	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
745310001998	active site
745310001999	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
745310002000	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
745310002001	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310002002	catalytic residue [active]
745310002003	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
745310002004	substrate binding site [chemical binding]; other site
745310002005	active site
745310002006	catalytic residues [active]
745310002007	heterodimer interface [polypeptide binding]; other site
745310002008	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
745310002009	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
745310002010	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
745310002011	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
745310002012	putative AMP binding site [chemical binding]; other site
745310002013	putative active site [active]
745310002014	acyl-activating enzyme (AAE) consensus motif; other site
745310002015	putative CoA binding site [chemical binding]; other site
745310002016	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310002017	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310002018	active site
745310002019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310002020	Coenzyme A binding pocket [chemical binding]; other site
745310002021	Predicted ATPase [General function prediction only]; Region: COG3911
745310002022	AAA domain; Region: AAA_28; pfam13521
745310002023	homoserine O-succinyltransferase; Provisional; Region: PRK05368
745310002024	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
745310002025	proposed active site lysine [active]
745310002026	conserved cys residue [active]
745310002027	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310002028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
745310002029	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
745310002030	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310002031	short chain dehydrogenase; Provisional; Region: PRK06172
745310002032	classical (c) SDRs; Region: SDR_c; cd05233
745310002033	NAD(P) binding site [chemical binding]; other site
745310002034	active site
745310002035	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310002036	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310002037	active site
745310002038	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310002039	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
745310002040	phosphate binding site [ion binding]; other site
745310002041	hypothetical protein; Validated; Region: PRK07121
745310002042	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
745310002043	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
745310002044	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
745310002045	active site
745310002046	catalytic residues [active]
745310002047	metal binding site [ion binding]; metal-binding site
745310002048	DmpG-like communication domain; Region: DmpG_comm; pfam07836
745310002049	acetaldehyde dehydrogenase; Validated; Region: PRK08300
745310002050	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
745310002051	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
745310002052	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
745310002053	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310002054	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
745310002055	Flavin binding site [chemical binding]; other site
745310002056	short chain dehydrogenase; Provisional; Region: PRK08303
745310002057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310002058	NAD(P) binding site [chemical binding]; other site
745310002059	active site
745310002060	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
745310002061	Transglycosylase; Region: Transgly; cl17702
745310002062	NAD-dependent deacetylase; Provisional; Region: PRK00481
745310002063	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
745310002064	NAD+ binding site [chemical binding]; other site
745310002065	substrate binding site [chemical binding]; other site
745310002066	Zn binding site [ion binding]; other site
745310002067	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
745310002068	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
745310002069	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310002070	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310002071	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
745310002072	active site
745310002073	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
745310002074	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
745310002075	cytochrome b; Provisional; Region: CYTB; MTH00156
745310002076	interchain domain interface [polypeptide binding]; other site
745310002077	intrachain domain interface; other site
745310002078	heme bH binding site [chemical binding]; other site
745310002079	Qi binding site; other site
745310002080	heme bL binding site [chemical binding]; other site
745310002081	Qo binding site; other site
745310002082	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
745310002083	interchain domain interface [polypeptide binding]; other site
745310002084	intrachain domain interface; other site
745310002085	Qi binding site; other site
745310002086	Qo binding site; other site
745310002087	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
745310002088	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
745310002089	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
745310002090	[2Fe-2S] cluster binding site [ion binding]; other site
745310002091	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
745310002092	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
745310002093	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
745310002094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310002095	Coenzyme A binding pocket [chemical binding]; other site
745310002096	lipoate-protein ligase B; Provisional; Region: PRK14341
745310002097	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
745310002098	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310002099	FeS/SAM binding site; other site
745310002100	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
745310002101	Ligand Binding Site [chemical binding]; other site
745310002102	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
745310002103	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
745310002104	dimerization interface [polypeptide binding]; other site
745310002105	domain crossover interface; other site
745310002106	redox-dependent activation switch; other site
745310002107	ornithine carbamoyltransferase; Provisional; Region: PRK00779
745310002108	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
745310002109	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
745310002110	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
745310002111	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
745310002112	inhibitor-cofactor binding pocket; inhibition site
745310002113	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310002114	catalytic residue [active]
745310002115	ABC-2 type transporter; Region: ABC2_membrane; cl17235
745310002116	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
745310002117	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310002118	GcrA cell cycle regulator; Region: GcrA; cl11564
745310002119	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
745310002120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002121	active site
745310002122	phosphorylation site [posttranslational modification]
745310002123	intermolecular recognition site; other site
745310002124	dimerization interface [polypeptide binding]; other site
745310002125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310002126	Walker A motif; other site
745310002127	ATP binding site [chemical binding]; other site
745310002128	Walker B motif; other site
745310002129	arginine finger; other site
745310002130	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310002131	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
745310002132	GAF domain; Region: GAF; pfam01590
745310002133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310002134	ATP binding site [chemical binding]; other site
745310002135	Mg2+ binding site [ion binding]; other site
745310002136	G-X-G motif; other site
745310002137	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
745310002138	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
745310002139	Substrate binding site; other site
745310002140	Cupin domain; Region: Cupin_2; cl17218
745310002141	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310002142	sequence-specific DNA binding site [nucleotide binding]; other site
745310002143	salt bridge; other site
745310002144	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
745310002145	Domain of unknown function (DUF955); Region: DUF955; pfam06114
745310002146	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
745310002147	isocitrate lyase; Provisional; Region: PRK15063
745310002148	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
745310002149	tetramer interface [polypeptide binding]; other site
745310002150	active site
745310002151	Mg2+/Mn2+ binding site [ion binding]; other site
745310002152	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
745310002153	HIT family signature motif; other site
745310002154	catalytic residue [active]
745310002155	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
745310002156	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
745310002157	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
745310002158	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
745310002159	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
745310002160	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
745310002161	Predicted integral membrane protein [Function unknown]; Region: COG5616
745310002162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310002163	TPR motif; other site
745310002164	TPR repeat; Region: TPR_11; pfam13414
745310002165	binding surface
745310002166	Uncharacterized conserved protein [Function unknown]; Region: COG3482
745310002167	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310002168	uncharacterized domain; Region: TIGR00702
745310002169	YcaO-like family; Region: YcaO; pfam02624
745310002170	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310002171	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310002172	active site
745310002173	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310002174	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
745310002175	active site
745310002176	POT family; Region: PTR2; cl17359
745310002177	POT family; Region: PTR2; cl17359
745310002178	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
745310002179	putative FMN binding site [chemical binding]; other site
745310002180	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310002181	DNA-binding site [nucleotide binding]; DNA binding site
745310002182	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
745310002183	tartrate dehydrogenase; Region: TTC; TIGR02089
745310002184	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
745310002185	catalytic residues [active]
745310002186	dimer interface [polypeptide binding]; other site
745310002187	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
745310002188	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
745310002189	homodimer interface [polypeptide binding]; other site
745310002190	substrate-cofactor binding pocket; other site
745310002191	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310002192	catalytic residue [active]
745310002193	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
745310002194	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310002195	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310002196	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
745310002197	dimerization interface [polypeptide binding]; other site
745310002198	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
745310002199	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
745310002200	formate dehydrogenase; Provisional; Region: PRK07574
745310002201	NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302
745310002202	dimerization interface [polypeptide binding]; other site
745310002203	ligand binding site [chemical binding]; other site
745310002204	NAD binding site [chemical binding]; other site
745310002205	catalytic site [active]
745310002206	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310002207	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310002208	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
745310002209	dimerization interface [polypeptide binding]; other site
745310002210	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310002211	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
745310002212	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
745310002213	short chain dehydrogenase; Provisional; Region: PRK08267
745310002214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310002215	NAD(P) binding site [chemical binding]; other site
745310002216	active site
745310002217	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
745310002218	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
745310002219	NAD(P) binding site [chemical binding]; other site
745310002220	catalytic residues [active]
745310002221	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310002222	CoenzymeA binding site [chemical binding]; other site
745310002223	subunit interaction site [polypeptide binding]; other site
745310002224	PHB binding site; other site
745310002225	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
745310002226	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
745310002227	tetramer interface [polypeptide binding]; other site
745310002228	catalytic Zn binding site [ion binding]; other site
745310002229	NADP binding site [chemical binding]; other site
745310002230	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310002231	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310002232	dimer interface [polypeptide binding]; other site
745310002233	putative CheW interface [polypeptide binding]; other site
745310002234	choline dehydrogenase; Validated; Region: PRK02106
745310002235	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
745310002236	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310002237	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310002238	active site
745310002239	catalytic tetrad [active]
745310002240	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
745310002241	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
745310002242	active site
745310002243	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
745310002244	homotrimer interaction site [polypeptide binding]; other site
745310002245	putative active site [active]
745310002246	Epoxide hydrolase N terminus; Region: EHN; pfam06441
745310002247	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310002248	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
745310002249	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310002250	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
745310002251	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310002252	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310002253	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
745310002254	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310002255	catalytic loop [active]
745310002256	iron binding site [ion binding]; other site
745310002257	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
745310002258	Cytochrome c; Region: Cytochrom_C; pfam00034
745310002259	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
745310002260	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
745310002261	Repair protein; Region: Repair_PSII; cl01535
745310002262	Repair protein; Region: Repair_PSII; pfam04536
745310002263	LemA family; Region: LemA; pfam04011
745310002264	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310002265	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310002266	hypothetical protein; Validated; Region: PRK07121
745310002267	Predicted oxidoreductase [General function prediction only]; Region: COG3573
745310002268	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
745310002269	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310002270	dimer interface [polypeptide binding]; other site
745310002271	substrate binding site [chemical binding]; other site
745310002272	metal binding site [ion binding]; metal-binding site
745310002273	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
745310002274	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310002275	active site
745310002276	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
745310002277	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
745310002278	dimer interface [polypeptide binding]; other site
745310002279	active site
745310002280	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
745310002281	dimer interface [polypeptide binding]; other site
745310002282	active site
745310002283	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
745310002284	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310002285	DNA-binding site [nucleotide binding]; DNA binding site
745310002286	UTRA domain; Region: UTRA; pfam07702
745310002287	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
745310002288	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310002289	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310002290	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
745310002291	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
745310002292	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
745310002293	active site
745310002294	Fn3 associated; Region: Fn3_assoc; pfam13287
745310002295	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
745310002296	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
745310002297	HPr interaction site; other site
745310002298	glycerol kinase (GK) interaction site [polypeptide binding]; other site
745310002299	active site
745310002300	phosphorylation site [posttranslational modification]
745310002301	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
745310002302	dimerization domain swap beta strand [polypeptide binding]; other site
745310002303	regulatory protein interface [polypeptide binding]; other site
745310002304	active site
745310002305	regulatory phosphorylation site [posttranslational modification]; other site
745310002306	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
745310002307	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
745310002308	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
745310002309	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
745310002310	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
745310002311	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
745310002312	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
745310002313	active site turn [active]
745310002314	phosphorylation site [posttranslational modification]
745310002315	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
745310002316	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
745310002317	putative active site [active]
745310002318	catalytic site [active]
745310002319	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
745310002320	putative active site [active]
745310002321	catalytic site [active]
745310002322	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
745310002323	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
745310002324	Porin subfamily; Region: Porin_2; pfam02530
745310002325	arginine decarboxylase; Provisional; Region: PRK15029
745310002326	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
745310002327	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
745310002328	homodimer interface [polypeptide binding]; other site
745310002329	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310002330	catalytic residue [active]
745310002331	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
745310002332	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
745310002333	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310002334	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310002335	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
745310002336	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
745310002337	Low affinity iron permease; Region: Iron_permease; cl12096
745310002338	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
745310002339	putative deacylase active site [active]
745310002340	Protein of unknown function (DUF461); Region: DUF461; pfam04314
745310002341	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
745310002342	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
745310002343	nucleotide binding site [chemical binding]; other site
745310002344	NEF interaction site [polypeptide binding]; other site
745310002345	SBD interface [polypeptide binding]; other site
745310002346	chaperone protein DnaJ; Provisional; Region: PRK10767
745310002347	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
745310002348	HSP70 interaction site [polypeptide binding]; other site
745310002349	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
745310002350	substrate binding site [polypeptide binding]; other site
745310002351	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
745310002352	Zn binding sites [ion binding]; other site
745310002353	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
745310002354	dimer interface [polypeptide binding]; other site
745310002355	ribonuclease PH; Reviewed; Region: rph; PRK00173
745310002356	Ribonuclease PH; Region: RNase_PH_bact; cd11362
745310002357	hexamer interface [polypeptide binding]; other site
745310002358	active site
745310002359	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
745310002360	active site
745310002361	dimerization interface [polypeptide binding]; other site
745310002362	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
745310002363	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310002364	FeS/SAM binding site; other site
745310002365	HemN C-terminal domain; Region: HemN_C; pfam06969
745310002366	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
745310002367	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
745310002368	putative ligand binding site [chemical binding]; other site
745310002369	Predicted methyltransferases [General function prediction only]; Region: COG0313
745310002370	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
745310002371	putative SAM binding site [chemical binding]; other site
745310002372	putative homodimer interface [polypeptide binding]; other site
745310002373	hypothetical protein; Reviewed; Region: PRK12497
745310002374	glutathione synthetase; Provisional; Region: PRK05246
745310002375	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
745310002376	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
745310002377	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
745310002378	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
745310002379	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
745310002380	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310002381	active site
745310002382	DNA binding site [nucleotide binding]
745310002383	Int/Topo IB signature motif; other site
745310002384	Protein of unknown function, DUF484; Region: DUF484; cl17449
745310002385	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
745310002386	active site
745310002387	intersubunit interactions; other site
745310002388	catalytic residue [active]
745310002389	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
745310002390	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
745310002391	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310002392	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
745310002393	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310002394	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
745310002395	putative C-terminal domain interface [polypeptide binding]; other site
745310002396	putative GSH binding site (G-site) [chemical binding]; other site
745310002397	putative dimer interface [polypeptide binding]; other site
745310002398	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
745310002399	dimer interface [polypeptide binding]; other site
745310002400	N-terminal domain interface [polypeptide binding]; other site
745310002401	putative substrate binding pocket (H-site) [chemical binding]; other site
745310002402	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
745310002403	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
745310002404	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
745310002405	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
745310002406	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
745310002407	Low molecular weight phosphatase family; Region: LMWPc; cd00115
745310002408	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
745310002409	active site
745310002410	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
745310002411	E-class dimer interface [polypeptide binding]; other site
745310002412	P-class dimer interface [polypeptide binding]; other site
745310002413	active site
745310002414	Cu2+ binding site [ion binding]; other site
745310002415	Zn2+ binding site [ion binding]; other site
745310002416	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
745310002417	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
745310002418	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310002419	catalytic loop [active]
745310002420	iron binding site [ion binding]; other site
745310002421	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
745310002422	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
745310002423	minor groove reading motif; other site
745310002424	helix-hairpin-helix signature motif; other site
745310002425	active site
745310002426	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
745310002427	CTP synthetase; Validated; Region: pyrG; PRK05380
745310002428	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
745310002429	Catalytic site [active]
745310002430	active site
745310002431	UTP binding site [chemical binding]; other site
745310002432	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
745310002433	active site
745310002434	putative oxyanion hole; other site
745310002435	catalytic triad [active]
745310002436	Preprotein translocase SecG subunit; Region: SecG; pfam03840
745310002437	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
745310002438	Fe-S cluster binding site [ion binding]; other site
745310002439	active site
745310002440	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310002441	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310002442	active site
745310002443	catalytic tetrad [active]
745310002444	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
745310002445	Walker A/P-loop; other site
745310002446	ATP binding site [chemical binding]; other site
745310002447	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
745310002448	ABC transporter signature motif; other site
745310002449	Walker B; other site
745310002450	D-loop; other site
745310002451	H-loop/switch region; other site
745310002452	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
745310002453	Thioredoxin; Region: Thioredoxin_4; pfam13462
745310002454	Cytochrome c2 [Energy production and conversion]; Region: COG3474
745310002455	prephenate dehydratase; Provisional; Region: PRK11899
745310002456	Prephenate dehydratase; Region: PDT; pfam00800
745310002457	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
745310002458	putative L-Phe binding site [chemical binding]; other site
745310002459	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
745310002460	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
745310002461	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
745310002462	putative NADH binding site [chemical binding]; other site
745310002463	putative active site [active]
745310002464	nudix motif; other site
745310002465	putative metal binding site [ion binding]; other site
745310002466	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
745310002467	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
745310002468	minor groove reading motif; other site
745310002469	helix-hairpin-helix signature motif; other site
745310002470	substrate binding pocket [chemical binding]; other site
745310002471	active site
745310002472	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
745310002473	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
745310002474	DNA binding and oxoG recognition site [nucleotide binding]
745310002475	Protein of unknown function (DUF721); Region: DUF721; cl02324
745310002476	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
745310002477	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
745310002478	catalytic residues [active]
745310002479	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
745310002480	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
745310002481	putative active site [active]
745310002482	putative metal binding site [ion binding]; other site
745310002483	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
745310002484	hypothetical protein; Provisional; Region: PRK06194
745310002485	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310002486	NAD(P) binding site [chemical binding]; other site
745310002487	active site
745310002488	hypothetical protein; Provisional; Region: PRK08912
745310002489	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310002490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310002491	homodimer interface [polypeptide binding]; other site
745310002492	catalytic residue [active]
745310002493	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
745310002494	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
745310002495	putative MPT binding site; other site
745310002496	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
745310002497	active site
745310002498	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
745310002499	Active_site [active]
745310002500	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
745310002501	Nitrogen regulatory protein P-II; Region: P-II; smart00938
745310002502	glutamine synthetase; Provisional; Region: glnA; PRK09469
745310002503	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
745310002504	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
745310002505	short chain dehydrogenase; Provisional; Region: PRK12829
745310002506	classical (c) SDRs; Region: SDR_c; cd05233
745310002507	NAD(P) binding site [chemical binding]; other site
745310002508	active site
745310002509	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310002510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310002511	dimer interface [polypeptide binding]; other site
745310002512	phosphorylation site [posttranslational modification]
745310002513	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310002514	ATP binding site [chemical binding]; other site
745310002515	Mg2+ binding site [ion binding]; other site
745310002516	G-X-G motif; other site
745310002517	Response regulator receiver domain; Region: Response_reg; pfam00072
745310002518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002519	active site
745310002520	phosphorylation site [posttranslational modification]
745310002521	intermolecular recognition site; other site
745310002522	dimerization interface [polypeptide binding]; other site
745310002523	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
745310002524	triosephosphate isomerase; Provisional; Region: PRK14565
745310002525	substrate binding site [chemical binding]; other site
745310002526	dimer interface [polypeptide binding]; other site
745310002527	catalytic triad [active]
745310002528	SurA N-terminal domain; Region: SurA_N_3; cl07813
745310002529	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
745310002530	anthranilate synthase component I; Provisional; Region: PRK13573
745310002531	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
745310002532	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
745310002533	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
745310002534	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
745310002535	glutamine binding [chemical binding]; other site
745310002536	catalytic triad [active]
745310002537	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
745310002538	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
745310002539	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
745310002540	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
745310002541	active site
745310002542	ribulose/triose binding site [chemical binding]; other site
745310002543	phosphate binding site [ion binding]; other site
745310002544	substrate (anthranilate) binding pocket [chemical binding]; other site
745310002545	product (indole) binding pocket [chemical binding]; other site
745310002546	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
745310002547	trimer interface [polypeptide binding]; other site
745310002548	dimer interface [polypeptide binding]; other site
745310002549	putative active site [active]
745310002550	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
745310002551	dimer interface [polypeptide binding]; other site
745310002552	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
745310002553	putative functional site; other site
745310002554	putative MPT binding site; other site
745310002555	LexA repressor; Validated; Region: PRK00215
745310002556	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
745310002557	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
745310002558	Catalytic site [active]
745310002559	Competence protein; Region: Competence; pfam03772
745310002560	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
745310002561	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
745310002562	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
745310002563	active site
745310002564	HIGH motif; other site
745310002565	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
745310002566	active site
745310002567	KMSKS motif; other site
745310002568	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
745310002569	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
745310002570	dimer interface [polypeptide binding]; other site
745310002571	active site
745310002572	citrylCoA binding site [chemical binding]; other site
745310002573	NADH binding [chemical binding]; other site
745310002574	cationic pore residues; other site
745310002575	oxalacetate/citrate binding site [chemical binding]; other site
745310002576	coenzyme A binding site [chemical binding]; other site
745310002577	catalytic triad [active]
745310002578	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
745310002579	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
745310002580	active site
745310002581	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
745310002582	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
745310002583	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
745310002584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
745310002585	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
745310002586	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
745310002587	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
745310002588	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310002589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002590	active site
745310002591	phosphorylation site [posttranslational modification]
745310002592	intermolecular recognition site; other site
745310002593	dimerization interface [polypeptide binding]; other site
745310002594	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310002595	DNA binding site [nucleotide binding]
745310002596	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
745310002597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002598	active site
745310002599	phosphorylation site [posttranslational modification]
745310002600	intermolecular recognition site; other site
745310002601	dimerization interface [polypeptide binding]; other site
745310002602	CheB methylesterase; Region: CheB_methylest; pfam01339
745310002603	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002604	Response regulator receiver domain; Region: Response_reg; pfam00072
745310002605	active site
745310002606	phosphorylation site [posttranslational modification]
745310002607	intermolecular recognition site; other site
745310002608	dimerization interface [polypeptide binding]; other site
745310002609	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
745310002610	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
745310002611	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
745310002612	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
745310002613	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
745310002614	putative binding surface; other site
745310002615	active site
745310002616	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310002617	ATP binding site [chemical binding]; other site
745310002618	Mg2+ binding site [ion binding]; other site
745310002619	G-X-G motif; other site
745310002620	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
745310002621	active site
745310002622	multimer interface [polypeptide binding]; other site
745310002623	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
745310002624	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
745310002625	multifunctional aminopeptidase A; Provisional; Region: PRK00913
745310002626	interface (dimer of trimers) [polypeptide binding]; other site
745310002627	Substrate-binding/catalytic site; other site
745310002628	Zn-binding sites [ion binding]; other site
745310002629	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
745310002630	OstA-like protein; Region: OstA; cl00844
745310002631	Organic solvent tolerance protein; Region: OstA_C; pfam04453
745310002632	SurA N-terminal domain; Region: SurA_N; pfam09312
745310002633	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
745310002634	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
745310002635	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
745310002636	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
745310002637	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
745310002638	TPR repeat; Region: TPR_11; pfam13414
745310002639	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310002640	binding surface
745310002641	TPR motif; other site
745310002642	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
745310002643	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
745310002644	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
745310002645	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
745310002646	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
745310002647	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
745310002648	active site
745310002649	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310002650	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
745310002651	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
745310002652	Peptidase family M28; Region: Peptidase_M28; pfam04389
745310002653	metal binding site [ion binding]; metal-binding site
745310002654	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
745310002655	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
745310002656	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
745310002657	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
745310002658	Sel1-like repeats; Region: SEL1; smart00671
745310002659	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
745310002660	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
745310002661	active site
745310002662	substrate-binding site [chemical binding]; other site
745310002663	metal-binding site [ion binding]
745310002664	ATP binding site [chemical binding]; other site
745310002665	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310002666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002667	active site
745310002668	phosphorylation site [posttranslational modification]
745310002669	intermolecular recognition site; other site
745310002670	dimerization interface [polypeptide binding]; other site
745310002671	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310002672	DNA binding site [nucleotide binding]
745310002673	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
745310002674	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310002675	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310002676	dimer interface [polypeptide binding]; other site
745310002677	phosphorylation site [posttranslational modification]
745310002678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310002679	ATP binding site [chemical binding]; other site
745310002680	Mg2+ binding site [ion binding]; other site
745310002681	G-X-G motif; other site
745310002682	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
745310002683	Hpr binding site; other site
745310002684	active site
745310002685	homohexamer subunit interaction site [polypeptide binding]; other site
745310002686	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
745310002687	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
745310002688	active site
745310002689	active pocket/dimerization site; other site
745310002690	phosphorylation site [posttranslational modification]
745310002691	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
745310002692	dimerization domain swap beta strand [polypeptide binding]; other site
745310002693	regulatory protein interface [polypeptide binding]; other site
745310002694	active site
745310002695	regulatory phosphorylation site [posttranslational modification]; other site
745310002696	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
745310002697	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
745310002698	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
745310002699	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310002700	Ligand Binding Site [chemical binding]; other site
745310002701	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310002702	Ligand Binding Site [chemical binding]; other site
745310002703	RmuC family; Region: RmuC; pfam02646
745310002704	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
745310002705	dimerization interface [polypeptide binding]; other site
745310002706	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
745310002707	active site
745310002708	catalytic residues [active]
745310002709	metal binding site [ion binding]; metal-binding site
745310002710	recombination protein RecR; Reviewed; Region: recR; PRK00076
745310002711	RecR protein; Region: RecR; pfam02132
745310002712	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
745310002713	putative active site [active]
745310002714	putative metal-binding site [ion binding]; other site
745310002715	tetramer interface [polypeptide binding]; other site
745310002716	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
745310002717	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
745310002718	putative active site [active]
745310002719	substrate binding site [chemical binding]; other site
745310002720	putative cosubstrate binding site; other site
745310002721	catalytic site [active]
745310002722	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
745310002723	substrate binding site [chemical binding]; other site
745310002724	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
745310002725	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
745310002726	dimerization interface 3.5A [polypeptide binding]; other site
745310002727	active site
745310002728	FHIPEP family; Region: FHIPEP; pfam00771
745310002729	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
745310002730	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
745310002731	dimer interface [polypeptide binding]; other site
745310002732	active site
745310002733	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
745310002734	catalytic residues [active]
745310002735	substrate binding site [chemical binding]; other site
745310002736	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
745310002737	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310002738	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310002739	acyl-activating enzyme (AAE) consensus motif; other site
745310002740	acyl-activating enzyme (AAE) consensus motif; other site
745310002741	AMP binding site [chemical binding]; other site
745310002742	active site
745310002743	CoA binding site [chemical binding]; other site
745310002744	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
745310002745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310002746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310002747	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
745310002748	IHF dimer interface [polypeptide binding]; other site
745310002749	IHF - DNA interface [nucleotide binding]; other site
745310002750	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
745310002751	Found in ATP-dependent protease La (LON); Region: LON; smart00464
745310002752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310002753	Walker A motif; other site
745310002754	ATP binding site [chemical binding]; other site
745310002755	Walker B motif; other site
745310002756	arginine finger; other site
745310002757	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
745310002758	hypothetical protein; Provisional; Region: PRK05208
745310002759	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
745310002760	GIY-YIG motif/motif A; other site
745310002761	putative active site [active]
745310002762	putative metal binding site [ion binding]; other site
745310002763	replicative DNA helicase; Provisional; Region: PRK09165
745310002764	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
745310002765	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
745310002766	Walker A motif; other site
745310002767	ATP binding site [chemical binding]; other site
745310002768	Walker B motif; other site
745310002769	DNA binding loops [nucleotide binding]
745310002770	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310002771	MarR family; Region: MarR_2; pfam12802
745310002772	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
745310002773	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310002774	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310002775	hypothetical protein; Provisional; Region: PRK02853
745310002776	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
745310002777	active site
745310002778	catalytic motif [active]
745310002779	Zn binding site [ion binding]; other site
745310002780	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
745310002781	trimer interface [polypeptide binding]; other site
745310002782	active site
745310002783	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
745310002784	catalytic motif [active]
745310002785	Catalytic residue [active]
745310002786	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
745310002787	catalytic motif [active]
745310002788	Catalytic residue [active]
745310002789	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
745310002790	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
745310002791	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
745310002792	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
745310002793	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
745310002794	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
745310002795	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
745310002796	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
745310002797	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
745310002798	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310002799	FeS/SAM binding site; other site
745310002800	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
745310002801	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
745310002802	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
745310002803	P loop; other site
745310002804	GTP binding site [chemical binding]; other site
745310002805	Intracellular septation protein A; Region: IspA; pfam04279
745310002806	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310002807	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310002808	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310002809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310002810	putative substrate translocation pore; other site
745310002811	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310002812	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
745310002813	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
745310002814	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
745310002815	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
745310002816	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
745310002817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310002818	Walker A motif; other site
745310002819	ATP binding site [chemical binding]; other site
745310002820	Walker B motif; other site
745310002821	arginine finger; other site
745310002822	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
745310002823	phage shock protein A; Region: phageshock_pspA; TIGR02977
745310002824	Phage shock protein B; Region: PspB; pfam06667
745310002825	phage shock protein C; Region: phageshock_pspC; TIGR02978
745310002826	PspC domain; Region: PspC; pfam04024
745310002827	Domain of unknown function (DUF4164); Region: DUF4164; pfam13747
745310002828	Fe-S metabolism associated domain; Region: SufE; cl00951
745310002829	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
745310002830	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310002831	MarR family; Region: MarR_2; cl17246
745310002832	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
745310002833	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
745310002834	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
745310002835	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
745310002836	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
745310002837	ligand binding site [chemical binding]; other site
745310002838	homodimer interface [polypeptide binding]; other site
745310002839	NAD(P) binding site [chemical binding]; other site
745310002840	trimer interface B [polypeptide binding]; other site
745310002841	trimer interface A [polypeptide binding]; other site
745310002842	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
745310002843	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
745310002844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310002845	active site
745310002846	phosphorylation site [posttranslational modification]
745310002847	intermolecular recognition site; other site
745310002848	dimerization interface [polypeptide binding]; other site
745310002849	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310002850	Walker A motif; other site
745310002851	ATP binding site [chemical binding]; other site
745310002852	Walker B motif; other site
745310002853	arginine finger; other site
745310002854	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310002855	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
745310002856	dihydropteroate synthase; Region: DHPS; TIGR01496
745310002857	substrate binding pocket [chemical binding]; other site
745310002858	dimer interface [polypeptide binding]; other site
745310002859	inhibitor binding site; inhibition site
745310002860	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
745310002861	DNA methylase; Region: N6_N4_Mtase; pfam01555
745310002862	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
745310002863	RNA/DNA hybrid binding site [nucleotide binding]; other site
745310002864	active site
745310002865	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
745310002866	dimer interface [polypeptide binding]; other site
745310002867	substrate binding site [chemical binding]; other site
745310002868	ATP binding site [chemical binding]; other site
745310002869	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
745310002870	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
745310002871	active site
745310002872	substrate binding site [chemical binding]; other site
745310002873	metal binding site [ion binding]; metal-binding site
745310002874	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
745310002875	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
745310002876	transcription elongation factor regulatory protein; Validated; Region: PRK06342
745310002877	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
745310002878	amino acid transporter; Region: 2A0306; TIGR00909
745310002879	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
745310002880	active site
745310002881	metal binding site [ion binding]; metal-binding site
745310002882	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
745310002883	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
745310002884	NAD binding site [chemical binding]; other site
745310002885	homodimer interface [polypeptide binding]; other site
745310002886	active site
745310002887	substrate binding site [chemical binding]; other site
745310002888	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
745310002889	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
745310002890	active site
745310002891	metal binding site [ion binding]; metal-binding site
745310002892	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
745310002893	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
745310002894	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
745310002895	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
745310002896	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
745310002897	SurA N-terminal domain; Region: SurA_N_3; cl07813
745310002898	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
745310002899	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
745310002900	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
745310002901	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
745310002902	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
745310002903	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
745310002904	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
745310002905	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
745310002906	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
745310002907	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
745310002908	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
745310002909	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
745310002910	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
745310002911	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
745310002912	substrate binding site; other site
745310002913	tetramer interface; other site
745310002914	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
745310002915	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
745310002916	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
745310002917	NADP binding site [chemical binding]; other site
745310002918	active site
745310002919	putative substrate binding site [chemical binding]; other site
745310002920	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
745310002921	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
745310002922	NAD binding site [chemical binding]; other site
745310002923	substrate binding site [chemical binding]; other site
745310002924	homodimer interface [polypeptide binding]; other site
745310002925	active site
745310002926	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
745310002927	Acyltransferase family; Region: Acyl_transf_3; pfam01757
745310002928	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
745310002929	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
745310002930	Probable Catalytic site; other site
745310002931	metal-binding site
745310002932	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
745310002933	active site
745310002934	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
745310002935	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310002936	acyl-activating enzyme (AAE) consensus motif; other site
745310002937	AMP binding site [chemical binding]; other site
745310002938	active site
745310002939	CoA binding site [chemical binding]; other site
745310002940	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
745310002941	putative trimer interface [polypeptide binding]; other site
745310002942	putative CoA binding site [chemical binding]; other site
745310002943	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
745310002944	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310002945	enoyl-CoA hydratase; Provisional; Region: PRK07509
745310002946	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310002947	substrate binding site [chemical binding]; other site
745310002948	oxyanion hole (OAH) forming residues; other site
745310002949	trimer interface [polypeptide binding]; other site
745310002950	Protein of unknown function (DUF983); Region: DUF983; cl02211
745310002951	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
745310002952	putative catalytic site [active]
745310002953	putative metal binding site [ion binding]; other site
745310002954	putative phosphate binding site [ion binding]; other site
745310002955	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
745310002956	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310002957	catalytic loop [active]
745310002958	iron binding site [ion binding]; other site
745310002959	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310002960	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
745310002961	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310002962	catalytic residue [active]
745310002963	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310002964	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
745310002965	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310002966	catalytic residue [active]
745310002967	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
745310002968	Serine hydrolase (FSH1); Region: FSH1; pfam03959
745310002969	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
745310002970	dimer interface [polypeptide binding]; other site
745310002971	active site
745310002972	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
745310002973	catalytic residues [active]
745310002974	substrate binding site [chemical binding]; other site
745310002975	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
745310002976	deoxyhypusine synthase; Region: dhys; TIGR00321
745310002977	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
745310002978	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
745310002979	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
745310002980	putative active site [active]
745310002981	catalytic site [active]
745310002982	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
745310002983	putative active site [active]
745310002984	catalytic site [active]
745310002985	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
745310002986	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
745310002987	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
745310002988	active site
745310002989	metal binding site [ion binding]; metal-binding site
745310002990	hexamer interface [polypeptide binding]; other site
745310002991	FHA domain; Region: FHA; pfam00498
745310002992	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
745310002993	heme-binding residues [chemical binding]; other site
745310002994	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
745310002995	heme-binding residues [chemical binding]; other site
745310002996	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
745310002997	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310002998	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
745310002999	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
745310003000	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
745310003001	ligand binding site [chemical binding]; other site
745310003002	flexible hinge region; other site
745310003003	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
745310003004	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
745310003005	ligand binding site [chemical binding]; other site
745310003006	flexible hinge region; other site
745310003007	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
745310003008	4Fe-4S binding domain; Region: Fer4; pfam00037
745310003009	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
745310003010	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310003011	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310003012	ligand binding site [chemical binding]; other site
745310003013	TIR domain; Region: TIR_2; pfam13676
745310003014	CAAX protease self-immunity; Region: Abi; pfam02517
745310003015	TPR repeat; Region: TPR_11; pfam13414
745310003016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310003017	binding surface
745310003018	TPR motif; other site
745310003019	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
745310003020	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
745310003021	homodimer interface [polypeptide binding]; other site
745310003022	active site
745310003023	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
745310003024	hypothetical protein; Validated; Region: PRK00124
745310003025	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
745310003026	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
745310003027	ATP binding site [chemical binding]; other site
745310003028	putative Mg++ binding site [ion binding]; other site
745310003029	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310003030	nucleotide binding region [chemical binding]; other site
745310003031	ATP-binding site [chemical binding]; other site
745310003032	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
745310003033	RNA binding site [nucleotide binding]; other site
745310003034	Predicted flavoproteins [General function prediction only]; Region: COG2081
745310003035	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310003036	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
745310003037	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
745310003038	NAD binding site [chemical binding]; other site
745310003039	substrate binding site [chemical binding]; other site
745310003040	catalytic Zn binding site [ion binding]; other site
745310003041	tetramer interface [polypeptide binding]; other site
745310003042	structural Zn binding site [ion binding]; other site
745310003043	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
745310003044	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310003045	Walker A/P-loop; other site
745310003046	ATP binding site [chemical binding]; other site
745310003047	Q-loop/lid; other site
745310003048	ABC transporter signature motif; other site
745310003049	Walker B; other site
745310003050	D-loop; other site
745310003051	H-loop/switch region; other site
745310003052	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
745310003053	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310003054	FtsX-like permease family; Region: FtsX; pfam02687
745310003055	prolyl-tRNA synthetase; Provisional; Region: PRK12325
745310003056	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
745310003057	dimer interface [polypeptide binding]; other site
745310003058	motif 1; other site
745310003059	active site
745310003060	motif 2; other site
745310003061	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
745310003062	active site
745310003063	motif 3; other site
745310003064	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
745310003065	anticodon binding site; other site
745310003066	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
745310003067	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
745310003068	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
745310003069	dimerization interface [polypeptide binding]; other site
745310003070	active site
745310003071	metal binding site [ion binding]; metal-binding site
745310003072	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
745310003073	GTPase Era; Reviewed; Region: era; PRK00089
745310003074	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
745310003075	G1 box; other site
745310003076	GTP/Mg2+ binding site [chemical binding]; other site
745310003077	Switch I region; other site
745310003078	G2 box; other site
745310003079	Switch II region; other site
745310003080	G3 box; other site
745310003081	G4 box; other site
745310003082	G5 box; other site
745310003083	KH domain; Region: KH_2; pfam07650
745310003084	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
745310003085	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
745310003086	DNA binding residues [nucleotide binding]
745310003087	dimer interface [polypeptide binding]; other site
745310003088	putative metal binding site [ion binding]; other site
745310003089	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310003090	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
745310003091	HSP70 interaction site [polypeptide binding]; other site
745310003092	Entericidin EcnA/B family; Region: Entericidin; cl02322
745310003093	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
745310003094	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
745310003095	amidase catalytic site [active]
745310003096	Zn binding residues [ion binding]; other site
745310003097	substrate binding site [chemical binding]; other site
745310003098	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
745310003099	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
745310003100	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
745310003101	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
745310003102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310003103	chemotaxis-specific methylesterase; Provisional; Region: PRK12555
745310003104	active site
745310003105	phosphorylation site [posttranslational modification]
745310003106	intermolecular recognition site; other site
745310003107	dimerization interface [polypeptide binding]; other site
745310003108	CheB methylesterase; Region: CheB_methylest; pfam01339
745310003109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310003110	Response regulator receiver domain; Region: Response_reg; pfam00072
745310003111	active site
745310003112	phosphorylation site [posttranslational modification]
745310003113	intermolecular recognition site; other site
745310003114	dimerization interface [polypeptide binding]; other site
745310003115	CheW-like domain; Region: CheW; pfam01584
745310003116	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
745310003117	putative binding surface; other site
745310003118	active site
745310003119	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
745310003120	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003121	ATP binding site [chemical binding]; other site
745310003122	Mg2+ binding site [ion binding]; other site
745310003123	G-X-G motif; other site
745310003124	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
745310003125	CheW-like domain; Region: CheW; pfam01584
745310003126	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
745310003127	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
745310003128	MPN+ (JAMM) motif; other site
745310003129	Zinc-binding site [ion binding]; other site
745310003130	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
745310003131	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310003132	RNA binding surface [nucleotide binding]; other site
745310003133	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
745310003134	active site
745310003135	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
745310003136	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
745310003137	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310003138	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310003139	DNA binding residues [nucleotide binding]
745310003140	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310003141	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310003142	[2Fe-2S] cluster binding site [ion binding]; other site
745310003143	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310003144	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310003145	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
745310003146	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
745310003147	putative DNA binding site [nucleotide binding]; other site
745310003148	putative Zn2+ binding site [ion binding]; other site
745310003149	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
745310003150	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
745310003151	AsnC family; Region: AsnC_trans_reg; pfam01037
745310003152	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
745310003153	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
745310003154	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
745310003155	PEP-CTERM motif; Region: VPEP; pfam07589
745310003156	PAS fold; Region: PAS; pfam00989
745310003157	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310003158	putative active site [active]
745310003159	heme pocket [chemical binding]; other site
745310003160	PAS domain; Region: PAS_9; pfam13426
745310003161	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310003162	dimer interface [polypeptide binding]; other site
745310003163	phosphorylation site [posttranslational modification]
745310003164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003165	ATP binding site [chemical binding]; other site
745310003166	Mg2+ binding site [ion binding]; other site
745310003167	G-X-G motif; other site
745310003168	enterobactin exporter EntS; Provisional; Region: PRK10489
745310003169	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
745310003170	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
745310003171	dimer interface [polypeptide binding]; other site
745310003172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310003173	catalytic residue [active]
745310003174	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310003175	CoenzymeA binding site [chemical binding]; other site
745310003176	subunit interaction site [polypeptide binding]; other site
745310003177	PHB binding site; other site
745310003178	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310003179	CoenzymeA binding site [chemical binding]; other site
745310003180	subunit interaction site [polypeptide binding]; other site
745310003181	PHB binding site; other site
745310003182	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
745310003183	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
745310003184	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
745310003185	Catalytic site; other site
745310003186	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
745310003187	enoyl-CoA hydratase; Provisional; Region: PRK08260
745310003188	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310003189	substrate binding site [chemical binding]; other site
745310003190	oxyanion hole (OAH) forming residues; other site
745310003191	trimer interface [polypeptide binding]; other site
745310003192	EthD domain; Region: EthD; pfam07110
745310003193	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310003194	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310003195	hypothetical protein; Validated; Region: PRK00153
745310003196	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
745310003197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310003198	Walker A motif; other site
745310003199	ATP binding site [chemical binding]; other site
745310003200	Walker B motif; other site
745310003201	arginine finger; other site
745310003202	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
745310003203	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
745310003204	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
745310003205	glutathionine S-transferase; Provisional; Region: PRK10542
745310003206	C-terminal domain interface [polypeptide binding]; other site
745310003207	GSH binding site (G-site) [chemical binding]; other site
745310003208	dimer interface [polypeptide binding]; other site
745310003209	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310003210	N-terminal domain interface [polypeptide binding]; other site
745310003211	dimer interface [polypeptide binding]; other site
745310003212	substrate binding pocket (H-site) [chemical binding]; other site
745310003213	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
745310003214	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
745310003215	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310003216	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310003217	ligand binding site [chemical binding]; other site
745310003218	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
745310003219	hypothetical protein; Provisional; Region: PRK06446
745310003220	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310003221	metal binding site [ion binding]; metal-binding site
745310003222	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310003223	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310003224	dimer interface [polypeptide binding]; other site
745310003225	putative CheW interface [polypeptide binding]; other site
745310003226	Protein of unknown function (DUF817); Region: DUF817; pfam05675
745310003227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
745310003228	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
745310003229	Transposase; Region: HTH_Tnp_1; pfam01527
745310003230	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310003231	Integrase core domain; Region: rve; pfam00665
745310003232	Integrase core domain; Region: rve_3; pfam13683
745310003233	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
745310003234	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
745310003235	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
745310003236	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
745310003237	active site
745310003238	HIGH motif; other site
745310003239	dimer interface [polypeptide binding]; other site
745310003240	KMSKS motif; other site
745310003241	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310003242	RNA binding surface [nucleotide binding]; other site
745310003243	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
745310003244	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
745310003245	ssDNA binding site; other site
745310003246	generic binding surface II; other site
745310003247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310003248	ATP binding site [chemical binding]; other site
745310003249	putative Mg++ binding site [ion binding]; other site
745310003250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310003251	nucleotide binding region [chemical binding]; other site
745310003252	ATP-binding site [chemical binding]; other site
745310003253	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
745310003254	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
745310003255	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
745310003256	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310003257	ATP binding site [chemical binding]; other site
745310003258	putative Mg++ binding site [ion binding]; other site
745310003259	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310003260	nucleotide binding region [chemical binding]; other site
745310003261	ATP-binding site [chemical binding]; other site
745310003262	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
745310003263	PEP-CTERM motif; Region: VPEP; pfam07589
745310003264	PRC-barrel domain; Region: PRC; pfam05239
745310003265	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
745310003266	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
745310003267	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003268	active site
745310003269	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310003271	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
745310003272	NAD(P) binding site [chemical binding]; other site
745310003273	active site
745310003274	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
745310003275	nucleophile elbow; other site
745310003276	Patatin phospholipase; Region: DUF3734; pfam12536
745310003277	Predicted metalloprotease [General function prediction only]; Region: COG2321
745310003278	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
745310003279	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
745310003280	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
745310003281	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
745310003282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310003283	S-adenosylmethionine binding site [chemical binding]; other site
745310003284	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
745310003285	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
745310003286	putative dimer interface [polypeptide binding]; other site
745310003287	active site pocket [active]
745310003288	putative cataytic base [active]
745310003289	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
745310003290	catalytic core [active]
745310003291	cobalamin synthase; Reviewed; Region: cobS; PRK00235
745310003292	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
745310003293	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
745310003294	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310003295	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
745310003296	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
745310003297	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
745310003298	E3 interaction surface; other site
745310003299	lipoyl attachment site [posttranslational modification]; other site
745310003300	e3 binding domain; Region: E3_binding; pfam02817
745310003301	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
745310003302	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
745310003303	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
745310003304	TPP-binding site [chemical binding]; other site
745310003305	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
745310003306	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
745310003307	CoA binding domain; Region: CoA_binding; smart00881
745310003308	CoA-ligase; Region: Ligase_CoA; pfam00549
745310003309	malate dehydrogenase; Reviewed; Region: PRK06223
745310003310	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
745310003311	NAD(P) binding site [chemical binding]; other site
745310003312	dimer interface [polypeptide binding]; other site
745310003313	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310003314	substrate binding site [chemical binding]; other site
745310003315	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
745310003316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003317	Mg2+ binding site [ion binding]; other site
745310003318	G-X-G motif; other site
745310003319	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
745310003320	anchoring element; other site
745310003321	dimer interface [polypeptide binding]; other site
745310003322	ATP binding site [chemical binding]; other site
745310003323	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
745310003324	active site
745310003325	putative metal-binding site [ion binding]; other site
745310003326	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
745310003327	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
745310003328	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
745310003329	metal binding site [ion binding]; metal-binding site
745310003330	putative dimer interface [polypeptide binding]; other site
745310003331	Protein of unknown function (DUF815); Region: DUF815; pfam05673
745310003332	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
745310003333	Walker A motif; other site
745310003334	ATP binding site [chemical binding]; other site
745310003335	Walker B motif; other site
745310003336	arginine finger; other site
745310003337	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
745310003338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310003339	S-adenosylmethionine binding site [chemical binding]; other site
745310003340	Peptidase family M48; Region: Peptidase_M48; cl12018
745310003341	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
745310003342	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
745310003343	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
745310003344	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
745310003345	Predicted permeases [General function prediction only]; Region: RarD; COG2962
745310003346	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
745310003347	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
745310003348	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
745310003349	motif 1; other site
745310003350	active site
745310003351	motif 2; other site
745310003352	motif 3; other site
745310003353	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
745310003354	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
745310003355	active site
745310003356	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
745310003357	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310003358	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
745310003359	putative C-terminal domain interface [polypeptide binding]; other site
745310003360	putative GSH binding site (G-site) [chemical binding]; other site
745310003361	putative dimer interface [polypeptide binding]; other site
745310003362	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
745310003363	putative N-terminal domain interface [polypeptide binding]; other site
745310003364	putative dimer interface [polypeptide binding]; other site
745310003365	putative substrate binding pocket (H-site) [chemical binding]; other site
745310003366	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
745310003367	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
745310003368	active site
745310003369	interdomain interaction site; other site
745310003370	putative metal-binding site [ion binding]; other site
745310003371	nucleotide binding site [chemical binding]; other site
745310003372	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
745310003373	domain I; other site
745310003374	DNA binding groove [nucleotide binding]
745310003375	phosphate binding site [ion binding]; other site
745310003376	domain II; other site
745310003377	domain III; other site
745310003378	nucleotide binding site [chemical binding]; other site
745310003379	catalytic site [active]
745310003380	domain IV; other site
745310003381	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
745310003382	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
745310003383	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
745310003384	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
745310003385	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
745310003386	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
745310003387	DNA protecting protein DprA; Region: dprA; TIGR00732
745310003388	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
745310003389	glutamate racemase; Provisional; Region: PRK00865
745310003390	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
745310003391	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
745310003392	substrate-cofactor binding pocket; other site
745310003393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310003394	catalytic residue [active]
745310003395	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
745310003396	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
745310003397	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
745310003398	dimer interface [polypeptide binding]; other site
745310003399	active site
745310003400	glycine-pyridoxal phosphate binding site [chemical binding]; other site
745310003401	folate binding site [chemical binding]; other site
745310003402	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
745310003403	Transcription elongation factor Elf1 like; Region: Elf1; cl02038
745310003404	ATP cone domain; Region: ATP-cone; pfam03477
745310003405	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
745310003406	GIY-YIG motif/motif A; other site
745310003407	putative active site [active]
745310003408	putative metal binding site [ion binding]; other site
745310003409	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
745310003410	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
745310003411	Chorismate mutase type II; Region: CM_2; cl00693
745310003412	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
745310003413	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
745310003414	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310003415	RNA binding surface [nucleotide binding]; other site
745310003416	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
745310003417	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
745310003418	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310003419	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310003420	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
745310003421	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
745310003422	PA/protease or protease-like domain interface [polypeptide binding]; other site
745310003423	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
745310003424	metal binding site [ion binding]; metal-binding site
745310003425	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
745310003426	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
745310003427	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
745310003428	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
745310003429	putative active site; other site
745310003430	catalytic triad [active]
745310003431	putative dimer interface [polypeptide binding]; other site
745310003432	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
745310003433	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
745310003434	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310003435	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
745310003436	phosphate binding site [ion binding]; other site
745310003437	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
745310003438	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
745310003439	putative NAD(P) binding site [chemical binding]; other site
745310003440	putative substrate binding site [chemical binding]; other site
745310003441	catalytic Zn binding site [ion binding]; other site
745310003442	structural Zn binding site [ion binding]; other site
745310003443	dimer interface [polypeptide binding]; other site
745310003444	oxidoreductase; Provisional; Region: PRK06196
745310003445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310003446	NAD(P) binding site [chemical binding]; other site
745310003447	active site
745310003448	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
745310003449	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310003450	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310003451	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
745310003452	Predicted acetyltransferase [General function prediction only]; Region: COG2388
745310003453	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
745310003454	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
745310003455	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
745310003456	putative catalytic cysteine [active]
745310003457	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
745310003458	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
745310003459	active site
745310003460	(T/H)XGH motif; other site
745310003461	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
745310003462	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
745310003463	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
745310003464	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310003465	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
745310003466	C-terminal peptidase (prc); Region: prc; TIGR00225
745310003467	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
745310003468	protein binding site [polypeptide binding]; other site
745310003469	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
745310003470	Catalytic dyad [active]
745310003471	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
745310003472	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
745310003473	diiron binding motif [ion binding]; other site
745310003474	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
745310003475	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
745310003476	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
745310003477	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
745310003478	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
745310003479	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
745310003480	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
745310003481	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
745310003482	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
745310003483	Surface antigen; Region: Bac_surface_Ag; pfam01103
745310003484	Surface antigen; Region: Bac_surface_Ag; pfam01103
745310003485	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
745310003486	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
745310003487	active site
745310003488	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
745310003489	protein binding site [polypeptide binding]; other site
745310003490	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
745310003491	putative substrate binding region [chemical binding]; other site
745310003492	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
745310003493	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
745310003494	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
745310003495	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
745310003496	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
745310003497	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
745310003498	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14834
745310003499	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
745310003500	catalytic residue [active]
745310003501	putative FPP diphosphate  binding site; other site
745310003502	putative FPP binding hydrophobic cleft; other site
745310003503	dimer interface [polypeptide binding]; other site
745310003504	putative IPP diphosphate binding site; other site
745310003505	ribosome recycling factor; Reviewed; Region: frr; PRK00083
745310003506	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
745310003507	hinge region; other site
745310003508	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
745310003509	putative nucleotide binding site [chemical binding]; other site
745310003510	uridine monophosphate binding site [chemical binding]; other site
745310003511	homohexameric interface [polypeptide binding]; other site
745310003512	elongation factor Ts; Provisional; Region: tsf; PRK09377
745310003513	UBA/TS-N domain; Region: UBA; pfam00627
745310003514	Elongation factor TS; Region: EF_TS; pfam00889
745310003515	Elongation factor TS; Region: EF_TS; pfam00889
745310003516	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
745310003517	rRNA interaction site [nucleotide binding]; other site
745310003518	S8 interaction site; other site
745310003519	putative laminin-1 binding site; other site
745310003520	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
745310003521	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
745310003522	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
745310003523	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
745310003524	isocitrate dehydrogenase; Validated; Region: PRK08299
745310003525	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310003526	dimer interface [polypeptide binding]; other site
745310003527	putative CheW interface [polypeptide binding]; other site
745310003528	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
745310003529	proximal quinone binding site [chemical binding]; other site
745310003530	SdhD (CybS) interface [polypeptide binding]; other site
745310003531	proximal heme binding site [chemical binding]; other site
745310003532	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
745310003533	putative SdhC subunit interface [polypeptide binding]; other site
745310003534	putative proximal heme binding site [chemical binding]; other site
745310003535	putative Iron-sulfur protein interface [polypeptide binding]; other site
745310003536	putative proximal quinone binding site; other site
745310003537	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
745310003538	L-aspartate oxidase; Provisional; Region: PRK06175
745310003539	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
745310003540	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
745310003541	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
745310003542	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310003543	CoenzymeA binding site [chemical binding]; other site
745310003544	subunit interaction site [polypeptide binding]; other site
745310003545	PHB binding site; other site
745310003546	Predicted ATPase [General function prediction only]; Region: COG1485
745310003547	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
745310003548	GIY-YIG motif/motif A; other site
745310003549	putative active site [active]
745310003550	putative metal binding site [ion binding]; other site
745310003551	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310003552	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003553	active site
745310003554	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003555	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
745310003556	active site
745310003557	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
745310003558	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
745310003559	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
745310003560	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
745310003561	Walker A/P-loop; other site
745310003562	ATP binding site [chemical binding]; other site
745310003563	Q-loop/lid; other site
745310003564	ABC transporter signature motif; other site
745310003565	Walker B; other site
745310003566	D-loop; other site
745310003567	H-loop/switch region; other site
745310003568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310003569	dimer interface [polypeptide binding]; other site
745310003570	conserved gate region; other site
745310003571	putative PBP binding loops; other site
745310003572	ABC-ATPase subunit interface; other site
745310003573	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
745310003574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310003575	dimer interface [polypeptide binding]; other site
745310003576	conserved gate region; other site
745310003577	putative PBP binding loops; other site
745310003578	ABC-ATPase subunit interface; other site
745310003579	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
745310003580	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
745310003581	substrate binding pocket [chemical binding]; other site
745310003582	membrane-bound complex binding site; other site
745310003583	hinge residues; other site
745310003584	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
745310003585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
745310003586	active site
745310003587	phosphorylation site [posttranslational modification]
745310003588	dimerization interface [polypeptide binding]; other site
745310003589	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310003590	DNA binding residues [nucleotide binding]
745310003591	dimerization interface [polypeptide binding]; other site
745310003592	ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972
745310003593	DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777
745310003594	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
745310003595	active site
745310003596	DNA binding site [nucleotide binding]
745310003597	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
745310003598	DNA binding site [nucleotide binding]
745310003599	PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862
745310003600	nucleotide binding site [chemical binding]; other site
745310003601	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
745310003602	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
745310003603	putative DNA binding site [nucleotide binding]; other site
745310003604	putative homodimer interface [polypeptide binding]; other site
745310003605	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
745310003606	putative deacylase active site [active]
745310003607	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
745310003608	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
745310003609	FAD binding pocket [chemical binding]; other site
745310003610	FAD binding motif [chemical binding]; other site
745310003611	phosphate binding motif [ion binding]; other site
745310003612	beta-alpha-beta structure motif; other site
745310003613	NAD binding pocket [chemical binding]; other site
745310003614	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310003615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310003616	active site
745310003617	phosphorylation site [posttranslational modification]
745310003618	intermolecular recognition site; other site
745310003619	dimerization interface [polypeptide binding]; other site
745310003620	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310003621	DNA binding site [nucleotide binding]
745310003622	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
745310003623	dimerization interface [polypeptide binding]; other site
745310003624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003625	ATP binding site [chemical binding]; other site
745310003626	Mg2+ binding site [ion binding]; other site
745310003627	G-X-G motif; other site
745310003628	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
745310003629	active site clefts [active]
745310003630	zinc binding site [ion binding]; other site
745310003631	dimer interface [polypeptide binding]; other site
745310003632	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
745310003633	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
745310003634	Sulfate transporter family; Region: Sulfate_transp; pfam00916
745310003635	STAS domain; Region: STAS_2; pfam13466
745310003636	TPR repeat; Region: TPR_11; pfam13414
745310003637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310003638	TPR motif; other site
745310003639	binding surface
745310003640	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
745310003641	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
745310003642	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
745310003643	substrate-cofactor binding pocket; other site
745310003644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310003645	catalytic residue [active]
745310003646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310003647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310003648	dimer interface [polypeptide binding]; other site
745310003649	phosphorylation site [posttranslational modification]
745310003650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003651	ATP binding site [chemical binding]; other site
745310003652	Mg2+ binding site [ion binding]; other site
745310003653	G-X-G motif; other site
745310003654	Response regulator receiver domain; Region: Response_reg; pfam00072
745310003655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310003656	active site
745310003657	phosphorylation site [posttranslational modification]
745310003658	intermolecular recognition site; other site
745310003659	dimerization interface [polypeptide binding]; other site
745310003660	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310003661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310003662	active site
745310003663	phosphorylation site [posttranslational modification]
745310003664	intermolecular recognition site; other site
745310003665	dimerization interface [polypeptide binding]; other site
745310003666	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310003667	DNA binding site [nucleotide binding]
745310003668	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254
745310003669	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
745310003670	FecR protein; Region: FecR; pfam04773
745310003671	CHASE2 domain; Region: CHASE2; pfam05226
745310003672	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
745310003673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003674	ATP binding site [chemical binding]; other site
745310003675	Mg2+ binding site [ion binding]; other site
745310003676	G-X-G motif; other site
745310003677	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
745310003678	catalytic residues [active]
745310003679	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
745310003680	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
745310003681	catalytic residues [active]
745310003682	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
745310003683	Family description; Region: UvrD_C_2; pfam13538
745310003684	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
745310003685	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
745310003686	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
745310003687	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
745310003688	Substrate binding site; other site
745310003689	metal-binding site
745310003690	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
745310003691	Phosphotransferase enzyme family; Region: APH; pfam01636
745310003692	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
745310003693	PAS fold; Region: PAS_7; pfam12860
745310003694	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
745310003695	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310003696	dimer interface [polypeptide binding]; other site
745310003697	phosphorylation site [posttranslational modification]
745310003698	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310003699	ATP binding site [chemical binding]; other site
745310003700	Mg2+ binding site [ion binding]; other site
745310003701	G-X-G motif; other site
745310003702	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
745310003703	NIPSNAP; Region: NIPSNAP; pfam07978
745310003704	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
745310003705	S-adenosylmethionine synthetase; Validated; Region: PRK05250
745310003706	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
745310003707	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
745310003708	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
745310003709	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
745310003710	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
745310003711	putative active site [active]
745310003712	catalytic triad [active]
745310003713	putative dimer interface [polypeptide binding]; other site
745310003714	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
745310003715	active site
745310003716	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
745310003717	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
745310003718	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310003719	Coenzyme A binding pocket [chemical binding]; other site
745310003720	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310003721	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
745310003722	Fe-S cluster binding site [ion binding]; other site
745310003723	DNA binding site [nucleotide binding]
745310003724	active site
745310003725	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
745310003726	catalytic center binding site [active]
745310003727	ATP binding site [chemical binding]; other site
745310003728	short chain dehydrogenase; Provisional; Region: PRK07890
745310003729	classical (c) SDRs; Region: SDR_c; cd05233
745310003730	NAD(P) binding site [chemical binding]; other site
745310003731	active site
745310003732	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310003733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310003734	SnoaL-like domain; Region: SnoaL_2; pfam12680
745310003735	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
745310003736	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
745310003737	active site
745310003738	FMN binding site [chemical binding]; other site
745310003739	substrate binding site [chemical binding]; other site
745310003740	putative catalytic residue [active]
745310003741	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
745310003742	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310003743	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310003744	classical (c) SDRs; Region: SDR_c; cd05233
745310003745	NAD(P) binding site [chemical binding]; other site
745310003746	active site
745310003747	short chain dehydrogenase; Provisional; Region: PRK07856
745310003748	classical (c) SDRs; Region: SDR_c; cd05233
745310003749	NAD(P) binding site [chemical binding]; other site
745310003750	active site
745310003751	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
745310003752	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
745310003753	NAD(P) binding site [chemical binding]; other site
745310003754	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
745310003755	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
745310003756	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310003757	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310003758	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
745310003759	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
745310003760	DNA-binding site [nucleotide binding]; DNA binding site
745310003761	RNA-binding motif; other site
745310003762	classical (c) SDRs; Region: SDR_c; cd05233
745310003763	NAD(P) binding site [chemical binding]; other site
745310003764	active site
745310003765	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310003766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310003767	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310003768	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
745310003769	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
745310003770	active site 1 [active]
745310003771	active site 2 [active]
745310003772	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
745310003773	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
745310003774	acyl-activating enzyme (AAE) consensus motif; other site
745310003775	putative AMP binding site [chemical binding]; other site
745310003776	putative active site [active]
745310003777	putative CoA binding site [chemical binding]; other site
745310003778	short chain dehydrogenase; Provisional; Region: PRK07856
745310003779	classical (c) SDRs; Region: SDR_c; cd05233
745310003780	NAD(P) binding site [chemical binding]; other site
745310003781	active site
745310003782	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310003783	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
745310003784	active site
745310003785	metal binding site [ion binding]; metal-binding site
745310003786	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
745310003787	Phosphotransferase enzyme family; Region: APH; pfam01636
745310003788	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
745310003789	putative active site [active]
745310003790	putative substrate binding site [chemical binding]; other site
745310003791	ATP binding site [chemical binding]; other site
745310003792	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310003793	substrate binding site [chemical binding]; other site
745310003794	oxyanion hole (OAH) forming residues; other site
745310003795	trimer interface [polypeptide binding]; other site
745310003796	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
745310003797	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310003798	substrate binding site [chemical binding]; other site
745310003799	oxyanion hole (OAH) forming residues; other site
745310003800	trimer interface [polypeptide binding]; other site
745310003801	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003802	active site
745310003803	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310003804	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
745310003805	lipid-transfer protein; Provisional; Region: PRK07855
745310003806	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
745310003807	active site
745310003808	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
745310003809	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
745310003810	DUF35 OB-fold domain; Region: DUF35; pfam01796
745310003811	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310003812	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310003813	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310003814	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310003815	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
745310003816	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
745310003817	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
745310003818	active site
745310003819	Fe binding site [ion binding]; other site
745310003820	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
745310003821	Coenzyme A transferase; Region: CoA_trans; cl17247
745310003822	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
745310003823	DUF35 OB-fold domain; Region: DUF35; pfam01796
745310003824	lipid-transfer protein; Provisional; Region: PRK06059
745310003825	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
745310003826	active site
745310003827	Nitronate monooxygenase; Region: NMO; pfam03060
745310003828	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310003829	FMN binding site [chemical binding]; other site
745310003830	substrate binding site [chemical binding]; other site
745310003831	putative catalytic residue [active]
745310003832	enoyl-CoA hydratase; Provisional; Region: PRK06495
745310003833	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310003834	substrate binding site [chemical binding]; other site
745310003835	oxyanion hole (OAH) forming residues; other site
745310003836	trimer interface [polypeptide binding]; other site
745310003837	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
745310003838	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
745310003839	FAD binding site [chemical binding]; other site
745310003840	substrate binding site [chemical binding]; other site
745310003841	catalytic base [active]
745310003842	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
745310003843	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310003844	active site
745310003845	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
745310003846	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310003847	dimer interface [polypeptide binding]; other site
745310003848	active site
745310003849	carnitine operon protein CaiE; Provisional; Region: PRK13627
745310003850	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
745310003851	putative trimer interface [polypeptide binding]; other site
745310003852	putative CoA binding site [chemical binding]; other site
745310003853	short chain dehydrogenase; Provisional; Region: PRK07791
745310003854	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
745310003855	homodimer interface [polypeptide binding]; other site
745310003856	NAD binding site [chemical binding]; other site
745310003857	active site
745310003858	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310003859	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
745310003860	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
745310003861	active site
745310003862	short chain dehydrogenase; Provisional; Region: PRK07831
745310003863	classical (c) SDRs; Region: SDR_c; cd05233
745310003864	NAD(P) binding site [chemical binding]; other site
745310003865	active site
745310003866	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
745310003867	putative active site [active]
745310003868	putative catalytic site [active]
745310003869	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310003870	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
745310003871	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310003872	dimer interface [polypeptide binding]; other site
745310003873	active site
745310003874	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
745310003875	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
745310003876	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
745310003877	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
745310003878	catalytic triad [active]
745310003879	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310003880	FMN binding site [chemical binding]; other site
745310003881	substrate binding site [chemical binding]; other site
745310003882	putative catalytic residue [active]
745310003883	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
745310003884	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
745310003885	NAD(P) binding site [chemical binding]; other site
745310003886	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
745310003887	Clp amino terminal domain; Region: Clp_N; pfam02861
745310003888	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310003889	Walker A motif; other site
745310003890	ATP binding site [chemical binding]; other site
745310003891	Walker B motif; other site
745310003892	arginine finger; other site
745310003893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310003894	Walker A motif; other site
745310003895	ATP binding site [chemical binding]; other site
745310003896	Walker B motif; other site
745310003897	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
745310003898	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
745310003899	primosome assembly protein PriA; Validated; Region: PRK05580
745310003900	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310003901	ATP binding site [chemical binding]; other site
745310003902	putative Mg++ binding site [ion binding]; other site
745310003903	helicase superfamily c-terminal domain; Region: HELICc; smart00490
745310003904	ATP-binding site [chemical binding]; other site
745310003905	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
745310003906	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
745310003907	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
745310003908	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
745310003909	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
745310003910	DNA binding site [nucleotide binding]
745310003911	active site
745310003912	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
745310003913	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
745310003914	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
745310003915	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
745310003916	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
745310003917	beta subunit interaction interface [polypeptide binding]; other site
745310003918	Walker A motif; other site
745310003919	ATP binding site [chemical binding]; other site
745310003920	Walker B motif; other site
745310003921	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
745310003922	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
745310003923	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
745310003924	core domain interface [polypeptide binding]; other site
745310003925	delta subunit interface [polypeptide binding]; other site
745310003926	epsilon subunit interface [polypeptide binding]; other site
745310003927	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
745310003928	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
745310003929	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
745310003930	alpha subunit interaction interface [polypeptide binding]; other site
745310003931	Walker A motif; other site
745310003932	ATP binding site [chemical binding]; other site
745310003933	Walker B motif; other site
745310003934	inhibitor binding site; inhibition site
745310003935	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
745310003936	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
745310003937	gamma subunit interface [polypeptide binding]; other site
745310003938	epsilon subunit interface [polypeptide binding]; other site
745310003939	LBP interface [polypeptide binding]; other site
745310003940	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
745310003941	active site
745310003942	catalytic triad [active]
745310003943	oxyanion hole [active]
745310003944	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
745310003945	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
745310003946	ATP binding site [chemical binding]; other site
745310003947	Walker A motif; other site
745310003948	hexamer interface [polypeptide binding]; other site
745310003949	Walker B motif; other site
745310003950	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003951	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003952	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003953	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003954	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003955	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003956	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003957	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003958	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003959	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003960	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003961	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003962	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310003963	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
745310003964	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
745310003965	Autotransporter beta-domain; Region: Autotransporter; pfam03797
745310003966	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
745310003967	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
745310003968	dihydroorotase; Validated; Region: PRK09060
745310003969	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310003970	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
745310003971	active site
745310003972	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
745310003973	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
745310003974	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
745310003975	active site
745310003976	Int/Topo IB signature motif; other site
745310003977	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930
745310003978	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
745310003979	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
745310003980	Catalytic site; other site
745310003981	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
745310003982	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
745310003983	cofactor binding site; other site
745310003984	DNA binding site [nucleotide binding]
745310003985	substrate interaction site [chemical binding]; other site
745310003986	Protein of unknown function (DUF968); Region: DUF968; pfam06147
745310003987	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
745310003988	ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283
745310003989	nad+ binding pocket [chemical binding]; other site
745310003990	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
745310003991	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310003992	non-specific DNA binding site [nucleotide binding]; other site
745310003993	salt bridge; other site
745310003994	sequence-specific DNA binding site [nucleotide binding]; other site
745310003995	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
745310003996	Catalytic site [active]
745310003997	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310003998	non-specific DNA binding site [nucleotide binding]; other site
745310003999	salt bridge; other site
745310004000	sequence-specific DNA binding site [nucleotide binding]; other site
745310004001	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
745310004002	MT-A70; Region: MT-A70; cl01947
745310004003	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
745310004004	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
745310004005	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
745310004006	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
745310004007	active site
745310004008	Phage Terminase; Region: Terminase_1; pfam03354
745310004009	Phage-related protein [Function unknown]; Region: COG4695; cl01923
745310004010	Phage portal protein; Region: Phage_portal; pfam04860
745310004011	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
745310004012	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
745310004013	Phage capsid family; Region: Phage_capsid; pfam05065
745310004014	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
745310004015	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
745310004016	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
745310004017	oligomerization interface [polypeptide binding]; other site
745310004018	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
745310004019	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
745310004020	Phage major tail protein 2; Region: Phage_tail_2; cl11463
745310004021	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
745310004022	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
745310004023	Phage-related minor tail protein [Function unknown]; Region: COG5281
745310004024	tape measure domain; Region: tape_meas_nterm; TIGR02675
745310004025	Putative phage tail protein; Region: Phage-tail_3; pfam13550
745310004026	Predicted chitinase [General function prediction only]; Region: COG3179
745310004027	catalytic residue [active]
745310004028	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
745310004029	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310004030	salt bridge; other site
745310004031	non-specific DNA binding site [nucleotide binding]; other site
745310004032	sequence-specific DNA binding site [nucleotide binding]; other site
745310004033	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310004034	Predicted transcriptional regulator [Transcription]; Region: COG1959
745310004035	Transcriptional regulator; Region: Rrf2; pfam02082
745310004036	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
745310004037	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
745310004038	active site
745310004039	DNA binding site [nucleotide binding]
745310004040	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
745310004041	DNA binding site [nucleotide binding]
745310004042	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
745310004043	D-galactonate transporter; Region: 2A0114; TIGR00893
745310004044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310004045	putative substrate translocation pore; other site
745310004046	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
745310004047	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
745310004048	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
745310004049	TAP-like protein; Region: Abhydrolase_4; pfam08386
745310004050	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
745310004051	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
745310004052	DXD motif; other site
745310004053	classical (c) SDRs; Region: SDR_c; cd05233
745310004054	NAD(P) binding site [chemical binding]; other site
745310004055	active site
745310004056	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
745310004057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310004058	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
745310004059	NAD(P) binding site [chemical binding]; other site
745310004060	active site
745310004061	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004062	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
745310004063	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004064	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
745310004065	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310004066	active site
745310004067	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310004068	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310004069	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004070	Domain of unknown function (DUF4279); Region: DUF4279; pfam14106
745310004071	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
745310004072	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
745310004073	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
745310004074	Multicopper oxidase; Region: Cu-oxidase; pfam00394
745310004075	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
745310004076	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
745310004077	Predicted flavoprotein [General function prediction only]; Region: COG0431
745310004078	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
745310004079	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
745310004080	active site
745310004081	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
745310004082	putative deacylase active site [active]
745310004083	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
745310004084	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310004085	FAD binding site [chemical binding]; other site
745310004086	substrate binding pocket [chemical binding]; other site
745310004087	catalytic base [active]
745310004088	Protein of unknown function (DUF808); Region: DUF808; cl01002
745310004089	Predicted small secreted protein [Function unknown]; Region: COG5510
745310004090	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
745310004091	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
745310004092	twin arginine translocase protein A; Provisional; Region: tatA; PRK00442
745310004093	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
745310004094	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
745310004095	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
745310004096	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
745310004097	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
745310004098	Sporulation related domain; Region: SPOR; pfam05036
745310004099	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
745310004100	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
745310004101	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
745310004102	active site
745310004103	HIGH motif; other site
745310004104	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310004105	KMSK motif region; other site
745310004106	tRNA binding surface [nucleotide binding]; other site
745310004107	DALR anticodon binding domain; Region: DALR_1; smart00836
745310004108	anticodon binding site; other site
745310004109	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
745310004110	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
745310004111	Zn2+ binding site [ion binding]; other site
745310004112	Mg2+ binding site [ion binding]; other site
745310004113	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
745310004114	TPR repeat; Region: TPR_11; pfam13414
745310004115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310004116	binding surface
745310004117	TPR motif; other site
745310004118	Sporulation related domain; Region: SPOR; pfam05036
745310004119	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
745310004120	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
745310004121	nucleotide binding site [chemical binding]; other site
745310004122	SulA interaction site; other site
745310004123	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
745310004124	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
745310004125	nucleotide binding site [chemical binding]; other site
745310004126	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
745310004127	Cell division protein FtsA; Region: FtsA; pfam14450
745310004128	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
745310004129	Cell division protein FtsQ; Region: FtsQ; pfam03799
745310004130	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
745310004131	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
745310004132	ATP-grasp domain; Region: ATP-grasp_4; cl17255
745310004133	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
745310004134	FAD binding domain; Region: FAD_binding_4; pfam01565
745310004135	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
745310004136	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
745310004137	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
745310004138	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
745310004139	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
745310004140	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
745310004141	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
745310004142	active site
745310004143	homodimer interface [polypeptide binding]; other site
745310004144	cell division protein FtsW; Region: ftsW; TIGR02614
745310004145	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
745310004146	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
745310004147	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
745310004148	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
745310004149	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
745310004150	Mg++ binding site [ion binding]; other site
745310004151	putative catalytic motif [active]
745310004152	putative substrate binding site [chemical binding]; other site
745310004153	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
745310004154	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
745310004155	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
745310004156	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
745310004157	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
745310004158	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
745310004159	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
745310004160	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
745310004161	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
745310004162	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
745310004163	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
745310004164	MraW methylase family; Region: Methyltransf_5; cl17771
745310004165	cell division protein MraZ; Reviewed; Region: PRK00326
745310004166	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
745310004167	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
745310004168	dimer interface [polypeptide binding]; other site
745310004169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310004170	catalytic residue [active]
745310004171	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
745310004172	putative dimer interface [polypeptide binding]; other site
745310004173	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310004174	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
745310004175	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
745310004176	dimerization interface [polypeptide binding]; other site
745310004177	ATP binding site [chemical binding]; other site
745310004178	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
745310004179	dimerization interface [polypeptide binding]; other site
745310004180	ATP binding site [chemical binding]; other site
745310004181	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
745310004182	Hemerythrin-like domain; Region: Hr-like; cd12108
745310004183	Predicted membrane protein [Function unknown]; Region: COG2311
745310004184	Protein of unknown function (DUF418); Region: DUF418; cl12135
745310004185	Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906
745310004186	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
745310004187	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
745310004188	heme binding site [chemical binding]; other site
745310004189	ferroxidase pore; other site
745310004190	ferroxidase diiron center [ion binding]; other site
745310004191	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
745310004192	Domain of unknown function DUF21; Region: DUF21; pfam01595
745310004193	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
745310004194	Transporter associated domain; Region: CorC_HlyC; smart01091
745310004195	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310004196	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310004197	ligand binding site [chemical binding]; other site
745310004198	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
745310004199	nucleoside/Zn binding site; other site
745310004200	dimer interface [polypeptide binding]; other site
745310004201	catalytic motif [active]
745310004202	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
745310004203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
745310004204	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
745310004205	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
745310004206	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
745310004207	metal ion-dependent adhesion site (MIDAS); other site
745310004208	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
745310004209	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
745310004210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310004211	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
745310004212	HSP70 interaction site [polypeptide binding]; other site
745310004213	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
745310004214	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310004215	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
745310004216	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
745310004217	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
745310004218	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
745310004219	NAD binding site [chemical binding]; other site
745310004220	dimerization interface [polypeptide binding]; other site
745310004221	product binding site; other site
745310004222	substrate binding site [chemical binding]; other site
745310004223	zinc binding site [ion binding]; other site
745310004224	catalytic residues [active]
745310004225	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
745310004226	thiamine-monophosphate kinase; Region: thiL; TIGR01379
745310004227	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
745310004228	ATP binding site [chemical binding]; other site
745310004229	dimerization interface [polypeptide binding]; other site
745310004230	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
745310004231	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310004232	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
745310004233	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
745310004234	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
745310004235	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
745310004236	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
745310004237	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
745310004238	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
745310004239	tetracycline repressor protein TetR; Provisional; Region: PRK13756
745310004240	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004241	RNA polymerase sigma factor; Reviewed; Region: PRK12527
745310004242	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
745310004243	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
745310004244	FecR protein; Region: FecR; pfam04773
745310004245	Secretin and TonB N terminus short domain; Region: STN; smart00965
745310004246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004247	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004248	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004249	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004250	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004251	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
745310004252	POT family; Region: PTR2; cl17359
745310004253	Transposase; Region: HTH_Tnp_1; pfam01527
745310004254	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310004255	Integrase core domain; Region: rve; pfam00665
745310004256	Integrase core domain; Region: rve_3; pfam13683
745310004257	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
745310004258	Autotransporter beta-domain; Region: Autotransporter; smart00869
745310004259	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
745310004260	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
745310004261	Sodium Bile acid symporter family; Region: SBF; cl17470
745310004262	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
745310004263	Sodium Bile acid symporter family; Region: SBF; cl17470
745310004264	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
745310004265	ArsC family; Region: ArsC; pfam03960
745310004266	catalytic residues [active]
745310004267	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
745310004268	Phage minor tail protein L; Region: Phage_tail_L; cl01908
745310004269	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
745310004270	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
745310004271	DNA binding site [nucleotide binding]
745310004272	Int/Topo IB signature motif; other site
745310004273	active site
745310004274	catalytic residues [active]
745310004275	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
745310004276	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
745310004277	Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856
745310004278	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
745310004279	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
745310004280	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
745310004281	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
745310004282	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
745310004283	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
745310004284	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
745310004285	flagellar motor switch protein FliN; Region: fliN; TIGR02480
745310004286	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
745310004287	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
745310004288	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
745310004289	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
745310004290	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
745310004291	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310004292	Walker A motif; other site
745310004293	ATP binding site [chemical binding]; other site
745310004294	Walker B motif; other site
745310004295	Flagellar assembly protein FliH; Region: FliH; pfam02108
745310004296	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
745310004297	MgtE intracellular N domain; Region: MgtE_N; smart00924
745310004298	FliG C-terminal domain; Region: FliG_C; pfam01706
745310004299	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
745310004300	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
745310004301	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
745310004302	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
745310004303	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
745310004304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310004305	Walker A motif; other site
745310004306	ATP binding site [chemical binding]; other site
745310004307	Walker B motif; other site
745310004308	arginine finger; other site
745310004309	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310004310	flagellin; Provisional; Region: PRK12802
745310004311	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004312	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
745310004313	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
745310004314	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310004315	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
745310004316	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310004317	DNA binding residues [nucleotide binding]
745310004318	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
745310004319	FHIPEP family; Region: FHIPEP; pfam00771
745310004320	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
745310004321	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
745310004322	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
745310004323	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12619
745310004324	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
745310004325	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
745310004326	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004327	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
745310004328	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
745310004329	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
745310004330	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
745310004331	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
745310004332	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004333	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
745310004334	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
745310004335	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
745310004336	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
745310004337	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004338	Flagellar L-ring protein; Region: FlgH; pfam02107
745310004339	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
745310004340	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
745310004341	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
745310004342	Rod binding protein; Region: Rod-binding; pfam10135
745310004343	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
745310004344	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004345	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
745310004346	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004347	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
745310004348	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
745310004349	Sulfatase; Region: Sulfatase; pfam00884
745310004350	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
745310004351	flagellar motor protein MotA; Validated; Region: PRK09110
745310004352	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
745310004353	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
745310004354	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310004355	ligand binding site [chemical binding]; other site
745310004356	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
745310004357	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
745310004358	GIY-YIG motif/motif A; other site
745310004359	active site
745310004360	catalytic site [active]
745310004361	putative DNA binding site [nucleotide binding]; other site
745310004362	metal binding site [ion binding]; metal-binding site
745310004363	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
745310004364	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
745310004365	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
745310004366	ATP synthase subunit C; Region: ATP-synt_C; cl00466
745310004367	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
745310004368	ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Region: ATP_synt_6_or_A; TIGR01131
745310004369	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
745310004370	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
745310004371	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
745310004372	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
745310004373	hypothetical protein; Reviewed; Region: PRK00024
745310004374	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
745310004375	MPN+ (JAMM) motif; other site
745310004376	Zinc-binding site [ion binding]; other site
745310004377	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
745310004378	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310004379	Walker A motif; other site
745310004380	ATP binding site [chemical binding]; other site
745310004381	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
745310004382	Walker B motif; other site
745310004383	arginine finger; other site
745310004384	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
745310004385	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
745310004386	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
745310004387	active site
745310004388	HslU subunit interaction site [polypeptide binding]; other site
745310004389	Protein of unknown function, DUF486; Region: DUF486; cl01236
745310004390	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
745310004391	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
745310004392	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
745310004393	Predicted permeases [General function prediction only]; Region: COG0795
745310004394	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
745310004395	Predicted permeases [General function prediction only]; Region: COG0795
745310004396	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
745310004397	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
745310004398	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
745310004399	active site
745310004400	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
745310004401	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
745310004402	active site
745310004403	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
745310004404	putative catalytic site [active]
745310004405	putative phosphate binding site [ion binding]; other site
745310004406	active site
745310004407	metal binding site A [ion binding]; metal-binding site
745310004408	DNA binding site [nucleotide binding]
745310004409	putative AP binding site [nucleotide binding]; other site
745310004410	putative metal binding site B [ion binding]; other site
745310004411	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
745310004412	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
745310004413	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310004414	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
745310004415	dinuclear metal binding motif [ion binding]; other site
745310004416	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
745310004417	catalytic triad [active]
745310004418	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
745310004419	metal binding triad; other site
745310004420	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
745310004421	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
745310004422	metal binding triad; other site
745310004423	RNA polymerase sigma factor; Provisional; Region: PRK12547
745310004424	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310004425	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
745310004426	two-component response regulator; Provisional; Region: PRK09191
745310004427	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
745310004428	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004429	active site
745310004430	phosphorylation site [posttranslational modification]
745310004431	intermolecular recognition site; other site
745310004432	dimerization interface [polypeptide binding]; other site
745310004433	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
745310004434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
745310004435	Histidine kinase; Region: HisKA_2; pfam07568
745310004436	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
745310004437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310004438	S-adenosylmethionine binding site [chemical binding]; other site
745310004439	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
745310004440	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
745310004441	phosphate binding site [ion binding]; other site
745310004442	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
745310004443	putative active site [active]
745310004444	putative catalytic site [active]
745310004445	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
745310004446	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310004447	ATP-grasp domain; Region: ATP-grasp_4; cl17255
745310004448	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
745310004449	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
745310004450	carboxyltransferase (CT) interaction site; other site
745310004451	biotinylation site [posttranslational modification]; other site
745310004452	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
745310004453	putative active site [active]
745310004454	putative metal binding site [ion binding]; other site
745310004455	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
745310004456	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
745310004457	isovaleryl-CoA dehydrogenase; Region: PLN02519
745310004458	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310004459	active site
745310004460	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310004461	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310004462	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
745310004463	dimerization interface [polypeptide binding]; other site
745310004464	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
745310004465	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
745310004466	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
745310004467	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
745310004468	guanine deaminase; Provisional; Region: PRK09228
745310004469	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
745310004470	active site
745310004471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
745310004472	Family of unknown function (DUF490); Region: DUF490; pfam04357
745310004473	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
745310004474	Surface antigen; Region: Bac_surface_Ag; pfam01103
745310004475	enoyl-CoA hydratase; Provisional; Region: PRK06494
745310004476	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310004477	substrate binding site [chemical binding]; other site
745310004478	oxyanion hole (OAH) forming residues; other site
745310004479	trimer interface [polypeptide binding]; other site
745310004480	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
745310004481	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
745310004482	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
745310004483	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
745310004484	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
745310004485	putative CheA interaction surface; other site
745310004486	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
745310004487	heme-binding site [chemical binding]; other site
745310004488	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
745310004489	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310004490	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310004491	dimer interface [polypeptide binding]; other site
745310004492	putative CheW interface [polypeptide binding]; other site
745310004493	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
745310004494	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
745310004495	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
745310004496	putative active site [active]
745310004497	putative substrate binding site [chemical binding]; other site
745310004498	putative cosubstrate binding site; other site
745310004499	catalytic site [active]
745310004500	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004501	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
745310004502	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004503	Domain of unknown function (DUF202); Region: DUF202; pfam02656
745310004504	short chain dehydrogenase; Provisional; Region: PRK09134
745310004505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310004506	NAD(P) binding site [chemical binding]; other site
745310004507	active site
745310004508	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310004509	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004510	Acylphosphatase; Region: Acylphosphatase; pfam00708
745310004511	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
745310004512	active site
745310004513	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
745310004514	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310004515	dimerization interface [polypeptide binding]; other site
745310004516	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310004517	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310004518	dimer interface [polypeptide binding]; other site
745310004519	putative CheW interface [polypeptide binding]; other site
745310004520	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
745310004521	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
745310004522	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
745310004523	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
745310004524	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
745310004525	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
745310004526	active site
745310004527	homotetramer interface [polypeptide binding]; other site
745310004528	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
745310004529	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310004530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004531	active site
745310004532	phosphorylation site [posttranslational modification]
745310004533	intermolecular recognition site; other site
745310004534	dimerization interface [polypeptide binding]; other site
745310004535	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310004536	DNA binding site [nucleotide binding]
745310004537	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310004538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310004539	dimerization interface [polypeptide binding]; other site
745310004540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310004541	ATP binding site [chemical binding]; other site
745310004542	Mg2+ binding site [ion binding]; other site
745310004543	G-X-G motif; other site
745310004544	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004545	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004546	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004547	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310004548	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310004549	potential frameshift: common BLAST hit: gi|374311808|ref|YP_005058238.1| coagulation factor 5/8 type domain-containing protein
745310004550	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
745310004551	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004552	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004553	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
745310004554	active site
745310004555	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
745310004556	substrate binding site [chemical binding]; other site
745310004557	active site
745310004558	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
745310004559	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
745310004560	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
745310004561	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
745310004562	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
745310004563	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
745310004564	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
745310004565	dimer interface [polypeptide binding]; other site
745310004566	NADP binding site [chemical binding]; other site
745310004567	catalytic residues [active]
745310004568	Transcriptional regulators [Transcription]; Region: FadR; COG2186
745310004569	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310004570	DNA-binding site [nucleotide binding]; DNA binding site
745310004571	FCD domain; Region: FCD; pfam07729
745310004572	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
745310004573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310004574	putative substrate translocation pore; other site
745310004575	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
745310004576	active site
745310004577	catalytic residues [active]
745310004578	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
745310004579	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
745310004580	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310004581	non-specific DNA binding site [nucleotide binding]; other site
745310004582	salt bridge; other site
745310004583	sequence-specific DNA binding site [nucleotide binding]; other site
745310004584	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
745310004585	active site
745310004586	catalytic residues [active]
745310004587	DNA binding site [nucleotide binding]
745310004588	Int/Topo IB signature motif; other site
745310004589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310004590	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310004591	dimer interface [polypeptide binding]; other site
745310004592	phosphorylation site [posttranslational modification]
745310004593	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
745310004594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310004595	putative DNA binding site [nucleotide binding]; other site
745310004596	putative Zn2+ binding site [ion binding]; other site
745310004597	AsnC family; Region: AsnC_trans_reg; pfam01037
745310004598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
745310004599	TPR motif; other site
745310004600	binding surface
745310004601	Protein of unknown function (DUF328); Region: DUF328; pfam03883
745310004602	DNA gyrase subunit A; Validated; Region: PRK05560
745310004603	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
745310004604	CAP-like domain; other site
745310004605	active site
745310004606	primary dimer interface [polypeptide binding]; other site
745310004607	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
745310004608	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
745310004609	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
745310004610	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
745310004611	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
745310004612	HNH endonuclease; Region: HNH; pfam01844
745310004613	active site
745310004614	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310004615	metal binding site [ion binding]; metal-binding site
745310004616	active site
745310004617	I-site; other site
745310004618	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310004619	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310004620	Rod binding protein; Region: Rod-binding; pfam10135
745310004621	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
745310004622	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
745310004623	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
745310004624	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
745310004625	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
745310004626	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
745310004627	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
745310004628	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
745310004629	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004630	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
745310004631	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
745310004632	Transposase domain (DUF772); Region: DUF772; pfam05598
745310004633	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310004634	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
745310004635	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
745310004636	PilZ domain; Region: PilZ; pfam07238
745310004637	PilZ domain; Region: PilZ; pfam07238
745310004638	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
745310004639	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
745310004640	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310004641	ligand binding site [chemical binding]; other site
745310004642	CheD chemotactic sensory transduction; Region: CheD; cl00810
745310004643	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
745310004644	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004645	active site
745310004646	phosphorylation site [posttranslational modification]
745310004647	intermolecular recognition site; other site
745310004648	dimerization interface [polypeptide binding]; other site
745310004649	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
745310004650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004651	active site
745310004652	phosphorylation site [posttranslational modification]
745310004653	intermolecular recognition site; other site
745310004654	dimerization interface [polypeptide binding]; other site
745310004655	CheB methylesterase; Region: CheB_methylest; pfam01339
745310004656	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
745310004657	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310004658	S-adenosylmethionine binding site [chemical binding]; other site
745310004659	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
745310004660	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
745310004661	putative binding surface; other site
745310004662	active site
745310004663	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
745310004664	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
745310004665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310004666	ATP binding site [chemical binding]; other site
745310004667	Mg2+ binding site [ion binding]; other site
745310004668	G-X-G motif; other site
745310004669	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
745310004670	Response regulator receiver domain; Region: Response_reg; pfam00072
745310004671	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004672	active site
745310004673	phosphorylation site [posttranslational modification]
745310004674	intermolecular recognition site; other site
745310004675	dimerization interface [polypeptide binding]; other site
745310004676	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
745310004677	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
745310004678	flagellar motor protein MotA; Validated; Region: PRK09110
745310004679	Flagellar protein FlaF; Region: FlaF; pfam07309
745310004680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
745310004681	PAS domain; Region: PAS_9; pfam13426
745310004682	putative active site [active]
745310004683	heme pocket [chemical binding]; other site
745310004684	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
745310004685	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310004686	putative active site [active]
745310004687	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310004688	dimer interface [polypeptide binding]; other site
745310004689	phosphorylation site [posttranslational modification]
745310004690	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310004691	ATP binding site [chemical binding]; other site
745310004692	Mg2+ binding site [ion binding]; other site
745310004693	G-X-G motif; other site
745310004694	response regulator FixJ; Provisional; Region: fixJ; PRK09390
745310004695	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310004696	active site
745310004697	phosphorylation site [posttranslational modification]
745310004698	intermolecular recognition site; other site
745310004699	dimerization interface [polypeptide binding]; other site
745310004700	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310004701	DNA binding residues [nucleotide binding]
745310004702	dimerization interface [polypeptide binding]; other site
745310004703	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
745310004704	active site
745310004705	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
745310004706	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
745310004707	HAMP domain; Region: HAMP; pfam00672
745310004708	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310004709	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
745310004710	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
745310004711	Predicted membrane protein [Function unknown]; Region: COG3174
745310004712	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
745310004713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310004714	NAD(P) binding site [chemical binding]; other site
745310004715	active site
745310004716	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
745310004717	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
745310004718	Walker A motif/ATP binding site; other site
745310004719	Walker B motif; other site
745310004720	Flagellar protein FlbT; Region: FlbT; cl11455
745310004721	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
745310004722	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
745310004723	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
745310004724	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004725	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
745310004726	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
745310004727	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004728	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
745310004729	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
745310004730	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310004731	Coenzyme A binding pocket [chemical binding]; other site
745310004732	Uncharacterized conserved protein [Function unknown]; Region: COG3334
745310004733	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
745310004734	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
745310004735	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
745310004736	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12689
745310004737	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
745310004738	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
745310004739	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
745310004740	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
745310004741	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
745310004742	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
745310004743	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
745310004744	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
745310004745	Domain of unknown function (DUF329); Region: DUF329; cl01144
745310004746	Maf-like protein; Region: Maf; pfam02545
745310004747	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
745310004748	active site
745310004749	dimer interface [polypeptide binding]; other site
745310004750	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
745310004751	rRNA binding site [nucleotide binding]; other site
745310004752	predicted 30S ribosome binding site; other site
745310004753	Cache domain; Region: Cache_1; pfam02743
745310004754	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310004755	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310004756	dimer interface [polypeptide binding]; other site
745310004757	putative CheW interface [polypeptide binding]; other site
745310004758	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06004
745310004759	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
745310004760	FliG C-terminal domain; Region: FliG_C; pfam01706
745310004761	flagellar assembly protein H; Validated; Region: fliH; PRK06032
745310004762	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
745310004763	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
745310004764	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
745310004765	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
745310004766	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310004767	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
745310004768	FHIPEP family; Region: FHIPEP; pfam00771
745310004769	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
745310004770	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
745310004771	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
745310004772	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
745310004773	flagellin; Reviewed; Region: PRK12687
745310004774	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004775	flagellin; Reviewed; Region: PRK12687
745310004776	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004777	flagellin; Reviewed; Region: PRK12687
745310004778	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004779	flagellin; Reviewed; Region: PRK12687
745310004780	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
745310004781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310004782	DNA-binding site [nucleotide binding]; DNA binding site
745310004783	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
745310004784	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310004785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310004786	homodimer interface [polypeptide binding]; other site
745310004787	catalytic residue [active]
745310004788	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
745310004789	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
745310004790	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
745310004791	active site 2 [active]
745310004792	active site 1 [active]
745310004793	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
745310004794	substrate binding site [chemical binding]; other site
745310004795	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
745310004796	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
745310004797	putative active site [active]
745310004798	putative PHP Thumb interface [polypeptide binding]; other site
745310004799	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
745310004800	generic binding surface II; other site
745310004801	generic binding surface I; other site
745310004802	DNA Polymerase Y-family; Region: PolY_like; cd03468
745310004803	active site
745310004804	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
745310004805	DNA binding site [nucleotide binding]
745310004806	Uncharacterized conserved protein [Function unknown]; Region: COG4544
745310004807	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
745310004808	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310004809	Coenzyme A binding pocket [chemical binding]; other site
745310004810	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
745310004811	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
745310004812	patatin-related protein; Region: TIGR03607
745310004813	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
745310004814	nucleophile elbow; other site
745310004815	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
745310004816	active site
745310004817	dimer interface [polypeptide binding]; other site
745310004818	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310004819	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310004820	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
745310004821	dimerization interface [polypeptide binding]; other site
745310004822	camphor resistance protein CrcB; Provisional; Region: PRK14195
745310004823	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
745310004824	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
745310004825	RNA binding surface [nucleotide binding]; other site
745310004826	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
745310004827	active site
745310004828	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
745310004829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310004830	active site
745310004831	motif I; other site
745310004832	motif II; other site
745310004833	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
745310004834	ATP12 chaperone protein; Region: ATP12; pfam07542
745310004835	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
745310004836	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
745310004837	GrpE; Region: GrpE; pfam01025
745310004838	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
745310004839	dimer interface [polypeptide binding]; other site
745310004840	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
745310004841	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
745310004842	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
745310004843	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310004844	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310004845	putative substrate translocation pore; other site
745310004846	Family of unknown function (DUF490); Region: DUF490; pfam04357
745310004847	Surface antigen; Region: Bac_surface_Ag; pfam01103
745310004848	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310004849	CoenzymeA binding site [chemical binding]; other site
745310004850	subunit interaction site [polypeptide binding]; other site
745310004851	PHB binding site; other site
745310004852	Preprotein translocase subunit; Region: YajC; pfam02699
745310004853	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
745310004854	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
745310004855	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
745310004856	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
745310004857	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
745310004858	Protein export membrane protein; Region: SecD_SecF; pfam02355
745310004859	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cl00182
745310004860	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
745310004861	Protein of unknown function (DUF1478); Region: DUF1478; pfam07349
745310004862	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
745310004863	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
745310004864	Walker A/P-loop; other site
745310004865	ATP binding site [chemical binding]; other site
745310004866	Q-loop/lid; other site
745310004867	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
745310004868	ABC transporter signature motif; other site
745310004869	Walker B; other site
745310004870	D-loop; other site
745310004871	H-loop/switch region; other site
745310004872	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310004873	metal binding site [ion binding]; metal-binding site
745310004874	active site
745310004875	I-site; other site
745310004876	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310004877	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
745310004878	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310004879	FeS/SAM binding site; other site
745310004880	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
745310004881	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
745310004882	ATP-NAD kinase; Region: NAD_kinase; pfam01513
745310004883	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
745310004884	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310004885	S-adenosylmethionine binding site [chemical binding]; other site
745310004886	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310004887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004888	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310004889	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310004890	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
745310004891	dimerization interface [polypeptide binding]; other site
745310004892	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310004893	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310004894	active site
745310004895	catalytic tetrad [active]
745310004896	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
745310004897	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310004898	putative substrate translocation pore; other site
745310004899	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
745310004900	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
745310004901	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
745310004902	Transcriptional regulators [Transcription]; Region: PurR; COG1609
745310004903	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
745310004904	DNA binding site [nucleotide binding]
745310004905	domain linker motif; other site
745310004906	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
745310004907	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310004908	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310004909	active site
745310004910	catalytic tetrad [active]
745310004911	Domain of unknown function (DUF336); Region: DUF336; pfam03928
745310004912	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
745310004913	active site
745310004914	metal binding site [ion binding]; metal-binding site
745310004915	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
745310004916	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004917	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310004918	N-terminal plug; other site
745310004919	ligand-binding site [chemical binding]; other site
745310004920	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310004921	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004922	Penicillin amidase; Region: Penicil_amidase; pfam01804
745310004923	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
745310004924	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
745310004925	active site
745310004926	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
745310004927	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310004928	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004929	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004930	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
745310004931	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
745310004932	active site
745310004933	metal binding site [ion binding]; metal-binding site
745310004934	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
745310004935	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
745310004936	Walker A/P-loop; other site
745310004937	ATP binding site [chemical binding]; other site
745310004938	Q-loop/lid; other site
745310004939	ABC transporter signature motif; other site
745310004940	Walker B; other site
745310004941	D-loop; other site
745310004942	H-loop/switch region; other site
745310004943	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
745310004944	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
745310004945	Walker A/P-loop; other site
745310004946	ATP binding site [chemical binding]; other site
745310004947	Q-loop/lid; other site
745310004948	ABC transporter signature motif; other site
745310004949	Walker B; other site
745310004950	D-loop; other site
745310004951	H-loop/switch region; other site
745310004952	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
745310004953	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
745310004954	TM-ABC transporter signature motif; other site
745310004955	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
745310004956	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
745310004957	TM-ABC transporter signature motif; other site
745310004958	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
745310004959	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
745310004960	putative ligand binding site [chemical binding]; other site
745310004961	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
745310004962	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
745310004963	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310004964	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310004966	TPR motif; other site
745310004967	binding surface
745310004968	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
745310004969	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310004970	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
745310004971	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310004972	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310004973	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
745310004974	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
745310004975	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310004976	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310004977	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
745310004978	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310004979	catalytic loop [active]
745310004980	iron binding site [ion binding]; other site
745310004981	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
745310004982	Cytochrome c; Region: Cytochrom_C; pfam00034
745310004983	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
745310004984	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
745310004985	Methylamine utilisation protein MauE; Region: MauE; pfam07291
745310004986	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
745310004987	agmatinase; Region: agmatinase; TIGR01230
745310004988	Agmatinase-like family; Region: Agmatinase-like; cd09990
745310004989	active site
745310004990	oligomer interface [polypeptide binding]; other site
745310004991	Mn binding site [ion binding]; other site
745310004992	agmatinase; Region: agmatinase; TIGR01230
745310004993	Agmatinase-like family; Region: Agmatinase-like; cd09990
745310004994	active site
745310004995	oligomer interface [polypeptide binding]; other site
745310004996	Mn binding site [ion binding]; other site
745310004997	UreD urease accessory protein; Region: UreD; pfam01774
745310004998	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
745310004999	alpha-gamma subunit interface [polypeptide binding]; other site
745310005000	beta-gamma subunit interface [polypeptide binding]; other site
745310005001	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
745310005002	gamma-beta subunit interface [polypeptide binding]; other site
745310005003	alpha-beta subunit interface [polypeptide binding]; other site
745310005004	urease subunit alpha; Reviewed; Region: ureC; PRK13207
745310005005	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
745310005006	subunit interactions [polypeptide binding]; other site
745310005007	active site
745310005008	flap region; other site
745310005009	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
745310005010	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
745310005011	dimer interface [polypeptide binding]; other site
745310005012	catalytic residues [active]
745310005013	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
745310005014	UreF; Region: UreF; pfam01730
745310005015	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
745310005016	G1 box; other site
745310005017	GTP/Mg2+ binding site [chemical binding]; other site
745310005018	G2 box; other site
745310005019	Switch I region; other site
745310005020	Switch II region; other site
745310005021	G3 box; other site
745310005022	G4 box; other site
745310005023	G5 box; other site
745310005024	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
745310005025	Na binding site [ion binding]; other site
745310005026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310005027	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310005028	dimer interface [polypeptide binding]; other site
745310005029	phosphorylation site [posttranslational modification]
745310005030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310005031	ATP binding site [chemical binding]; other site
745310005032	Mg2+ binding site [ion binding]; other site
745310005033	G-X-G motif; other site
745310005034	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
745310005035	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310005036	active site
745310005037	phosphorylation site [posttranslational modification]
745310005038	intermolecular recognition site; other site
745310005039	dimerization interface [polypeptide binding]; other site
745310005040	Response regulator receiver domain; Region: Response_reg; pfam00072
745310005041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310005042	active site
745310005043	phosphorylation site [posttranslational modification]
745310005044	intermolecular recognition site; other site
745310005045	dimerization interface [polypeptide binding]; other site
745310005046	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310005047	DNA binding residues [nucleotide binding]
745310005048	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
745310005049	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310005050	dimer interface [polypeptide binding]; other site
745310005051	active site
745310005052	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310005053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310005054	NAD(P) binding site [chemical binding]; other site
745310005055	active site
745310005056	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310005057	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310005058	putative acyl-CoA synthetase; Provisional; Region: PRK06018
745310005059	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310005060	acyl-activating enzyme (AAE) consensus motif; other site
745310005061	AMP binding site [chemical binding]; other site
745310005062	active site
745310005063	CoA binding site [chemical binding]; other site
745310005064	Carboxylesterase family; Region: COesterase; pfam00135
745310005065	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
745310005066	substrate binding pocket [chemical binding]; other site
745310005067	catalytic triad [active]
745310005068	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310005069	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310005070	putative substrate translocation pore; other site
745310005071	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310005072	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310005073	N-terminal plug; other site
745310005074	ligand-binding site [chemical binding]; other site
745310005075	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
745310005076	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310005077	hypothetical protein; Validated; Region: PRK07121
745310005078	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
745310005079	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
745310005080	classical (c) SDRs; Region: SDR_c; cd05233
745310005081	NAD(P) binding site [chemical binding]; other site
745310005082	active site
745310005083	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310005084	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
745310005085	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310005086	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310005087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310005088	NAD(P) binding site [chemical binding]; other site
745310005089	active site
745310005090	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
745310005091	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
745310005092	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310005093	hydroxyglutarate oxidase; Provisional; Region: PRK11728
745310005094	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
745310005095	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
745310005096	Serine hydrolase; Region: Ser_hydrolase; cl17834
745310005097	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
745310005098	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
745310005099	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
745310005100	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
745310005101	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
745310005102	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
745310005103	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
745310005104	Type IV pili component [Cell motility and secretion]; Region: COG5461
745310005105	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
745310005106	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
745310005107	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
745310005108	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
745310005109	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
745310005110	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
745310005111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310005112	S-adenosylmethionine binding site [chemical binding]; other site
745310005113	Uncharacterized conserved protein [Function unknown]; Region: COG3743
745310005114	pyruvate phosphate dikinase; Provisional; Region: PRK09279
745310005115	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
745310005116	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
745310005117	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
745310005118	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
745310005119	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
745310005120	dimer interface [polypeptide binding]; other site
745310005121	motif 1; other site
745310005122	active site
745310005123	motif 2; other site
745310005124	motif 3; other site
745310005125	TraB family; Region: TraB; pfam01963
745310005126	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
745310005127	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
745310005128	5S rRNA interface [nucleotide binding]; other site
745310005129	CTC domain interface [polypeptide binding]; other site
745310005130	L16 interface [polypeptide binding]; other site
745310005131	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
745310005132	putative active site [active]
745310005133	catalytic residue [active]
745310005134	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
745310005135	GTP-binding protein YchF; Reviewed; Region: PRK09601
745310005136	YchF GTPase; Region: YchF; cd01900
745310005137	G1 box; other site
745310005138	GTP/Mg2+ binding site [chemical binding]; other site
745310005139	Switch I region; other site
745310005140	G2 box; other site
745310005141	Switch II region; other site
745310005142	G3 box; other site
745310005143	G4 box; other site
745310005144	G5 box; other site
745310005145	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
745310005146	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
745310005147	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
745310005148	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
745310005149	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
745310005150	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
745310005151	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
745310005152	purine monophosphate binding site [chemical binding]; other site
745310005153	dimer interface [polypeptide binding]; other site
745310005154	putative catalytic residues [active]
745310005155	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
745310005156	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
745310005157	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
745310005158	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
745310005159	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
745310005160	substrate binding site [chemical binding]; other site
745310005161	hexamer interface [polypeptide binding]; other site
745310005162	metal binding site [ion binding]; metal-binding site
745310005163	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
745310005164	dimer interface [polypeptide binding]; other site
745310005165	ADP-ribose binding site [chemical binding]; other site
745310005166	active site
745310005167	nudix motif; other site
745310005168	metal binding site [ion binding]; metal-binding site
745310005169	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
745310005170	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
745310005171	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
745310005172	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
745310005173	RNase E interface [polypeptide binding]; other site
745310005174	trimer interface [polypeptide binding]; other site
745310005175	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
745310005176	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
745310005177	RNase E interface [polypeptide binding]; other site
745310005178	trimer interface [polypeptide binding]; other site
745310005179	active site
745310005180	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
745310005181	putative nucleic acid binding region [nucleotide binding]; other site
745310005182	G-X-X-G motif; other site
745310005183	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
745310005184	RNA binding site [nucleotide binding]; other site
745310005185	domain interface; other site
745310005186	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
745310005187	16S/18S rRNA binding site [nucleotide binding]; other site
745310005188	S13e-L30e interaction site [polypeptide binding]; other site
745310005189	25S rRNA binding site [nucleotide binding]; other site
745310005190	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
745310005191	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
745310005192	RNA binding site [nucleotide binding]; other site
745310005193	active site
745310005194	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
745310005195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310005196	Coenzyme A binding pocket [chemical binding]; other site
745310005197	thymidine kinase; Provisional; Region: PRK04296
745310005198	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
745310005199	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
745310005200	translation initiation factor IF-2; Region: IF-2; TIGR00487
745310005201	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
745310005202	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
745310005203	G1 box; other site
745310005204	putative GEF interaction site [polypeptide binding]; other site
745310005205	GTP/Mg2+ binding site [chemical binding]; other site
745310005206	Switch I region; other site
745310005207	G2 box; other site
745310005208	G3 box; other site
745310005209	Switch II region; other site
745310005210	G4 box; other site
745310005211	G5 box; other site
745310005212	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
745310005213	Translation-initiation factor 2; Region: IF-2; pfam11987
745310005214	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
745310005215	hypothetical protein; Provisional; Region: PRK09190
745310005216	Protein of unknown function (DUF448); Region: DUF448; pfam04296
745310005217	putative RNA binding cleft [nucleotide binding]; other site
745310005218	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
745310005219	NusA N-terminal domain; Region: NusA_N; pfam08529
745310005220	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
745310005221	RNA binding site [nucleotide binding]; other site
745310005222	homodimer interface [polypeptide binding]; other site
745310005223	NusA-like KH domain; Region: KH_5; pfam13184
745310005224	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
745310005225	G-X-X-G motif; other site
745310005226	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
745310005227	hypothetical protein; Provisional; Region: PRK14636
745310005228	Sm and related proteins; Region: Sm_like; cl00259
745310005229	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
745310005230	putative oligomer interface [polypeptide binding]; other site
745310005231	putative RNA binding site [nucleotide binding]; other site
745310005232	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
745310005233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
745310005234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310005235	S-adenosylmethionine binding site [chemical binding]; other site
745310005236	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
745310005237	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
745310005238	Predicted membrane protein [Function unknown]; Region: COG2119
745310005239	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
745310005240	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
745310005241	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
745310005242	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310005243	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310005244	N-terminal plug; other site
745310005245	ligand-binding site [chemical binding]; other site
745310005246	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
745310005247	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310005248	Walker A/P-loop; other site
745310005249	ATP binding site [chemical binding]; other site
745310005250	Q-loop/lid; other site
745310005251	ABC transporter signature motif; other site
745310005252	Walker B; other site
745310005253	D-loop; other site
745310005254	H-loop/switch region; other site
745310005255	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
745310005256	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
745310005257	ABC-ATPase subunit  interface; other site
745310005258	dimer interface [polypeptide binding]; other site
745310005259	putative PBP binding regions; other site
745310005260	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
745310005261	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
745310005262	intersubunit interface [polypeptide binding]; other site
745310005263	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
745310005264	FMN binding site [chemical binding]; other site
745310005265	dimer interface [polypeptide binding]; other site
745310005266	Protein of unknown function (DUF1428); Region: DUF1428; cl02319
745310005267	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
745310005268	PhnA protein; Region: PhnA; pfam03831
745310005269	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
745310005270	putative dimer interface [polypeptide binding]; other site
745310005271	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310005272	ligand binding site [chemical binding]; other site
745310005273	Zn binding site [ion binding]; other site
745310005274	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
745310005275	PEP-CTERM motif; Region: VPEP; pfam07589
745310005276	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
745310005277	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
745310005278	active site
745310005279	metal binding site [ion binding]; metal-binding site
745310005280	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
745310005281	RHS Repeat; Region: RHS_repeat; pfam05593
745310005282	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
745310005283	RHS Repeat; Region: RHS_repeat; pfam05593
745310005284	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
745310005285	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310005286	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310005287	catalytic residues [active]
745310005288	catalytic nucleophile [active]
745310005289	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310005290	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310005291	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310005292	Synaptic Site I dimer interface [polypeptide binding]; other site
745310005293	DNA binding site [nucleotide binding]
745310005294	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310005295	DNA-binding interface [nucleotide binding]; DNA binding site
745310005296	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
745310005297	Abi-like protein; Region: Abi_2; pfam07751
745310005298	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
745310005299	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
745310005300	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
745310005301	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
745310005302	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
745310005303	Methyltransferase domain; Region: Methyltransf_26; pfam13659
745310005304	MobA/MobL family; Region: MobA_MobL; pfam03389
745310005305	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
745310005306	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310005307	non-specific DNA binding site [nucleotide binding]; other site
745310005308	salt bridge; other site
745310005309	sequence-specific DNA binding site [nucleotide binding]; other site
745310005310	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
745310005311	Replication initiator protein A; Region: RPA; cl17860
745310005312	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
745310005313	ThiC-associated domain; Region: ThiC-associated; pfam13667
745310005314	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
745310005315	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
745310005316	lycopene cyclase; Region: lycopene_cycl; TIGR01789
745310005317	phytoene desaturase; Region: crtI_fam; TIGR02734
745310005318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
745310005319	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
745310005320	PspC domain; Region: PspC; pfam04024
745310005321	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
745310005322	putative ADP-binding pocket [chemical binding]; other site
745310005323	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
745310005324	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
745310005325	haloalkane dehalogenase; Provisional; Region: PRK00870
745310005326	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
745310005327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310005328	Integrase core domain; Region: rve; pfam00665
745310005329	Integrase core domain; Region: rve_3; pfam13683
745310005330	Transposase; Region: HTH_Tnp_1; pfam01527
745310005331	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
745310005332	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
745310005333	ligand binding site [chemical binding]; other site
745310005334	flexible hinge region; other site
745310005335	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
745310005336	putative switch regulator; other site
745310005337	non-specific DNA interactions [nucleotide binding]; other site
745310005338	DNA binding site [nucleotide binding]
745310005339	sequence specific DNA binding site [nucleotide binding]; other site
745310005340	putative cAMP binding site [chemical binding]; other site
745310005341	PAS domain; Region: PAS_9; pfam13426
745310005342	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310005343	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310005344	metal binding site [ion binding]; metal-binding site
745310005345	active site
745310005346	I-site; other site
745310005347	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310005348	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
745310005349	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310005350	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310005351	putative Zn2+ binding site [ion binding]; other site
745310005352	putative DNA binding site [nucleotide binding]; other site
745310005353	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
745310005354	active site
745310005355	catalytic residues [active]
745310005356	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310005357	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
745310005358	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
745310005359	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
745310005360	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005361	active site
745310005362	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005363	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
745310005364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310005365	sequence-specific DNA binding site [nucleotide binding]; other site
745310005366	salt bridge; other site
745310005367	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
745310005368	elongation factor G; Reviewed; Region: PRK12740
745310005369	G1 box; other site
745310005370	putative GEF interaction site [polypeptide binding]; other site
745310005371	GTP/Mg2+ binding site [chemical binding]; other site
745310005372	Switch I region; other site
745310005373	G2 box; other site
745310005374	G3 box; other site
745310005375	Switch II region; other site
745310005376	G4 box; other site
745310005377	G5 box; other site
745310005378	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
745310005379	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
745310005380	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
745310005381	PII uridylyl-transferase; Provisional; Region: PRK05092
745310005382	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
745310005383	metal binding triad; other site
745310005384	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
745310005385	HD domain; Region: HD; pfam01966
745310005386	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
745310005387	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
745310005388	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
745310005389	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310005390	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
745310005391	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
745310005392	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
745310005393	alphaNTD - beta interaction site [polypeptide binding]; other site
745310005394	alphaNTD homodimer interface [polypeptide binding]; other site
745310005395	alphaNTD - beta' interaction site [polypeptide binding]; other site
745310005396	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
745310005397	30S ribosomal protein S11; Validated; Region: PRK05309
745310005398	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
745310005399	30S ribosomal protein S13; Region: bact_S13; TIGR03631
745310005400	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
745310005401	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
745310005402	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310005403	catalytic residue [active]
745310005404	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
745310005405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310005406	S-adenosylmethionine binding site [chemical binding]; other site
745310005407	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
745310005408	AAA domain; Region: AAA_26; pfam13500
745310005409	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
745310005410	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
745310005411	inhibitor-cofactor binding pocket; inhibition site
745310005412	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310005413	catalytic residue [active]
745310005414	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
745310005415	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310005416	active site
745310005417	HIGH motif; other site
745310005418	nucleotide binding site [chemical binding]; other site
745310005419	Beta/Gamma crystallin; Region: Crystall; cl02528
745310005420	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
745310005421	hydrophobic ligand binding site; other site
745310005422	adenylate kinase; Reviewed; Region: adk; PRK00279
745310005423	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
745310005424	AMP-binding site [chemical binding]; other site
745310005425	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
745310005426	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
745310005427	SecY translocase; Region: SecY; pfam00344
745310005428	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
745310005429	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
745310005430	23S rRNA binding site [nucleotide binding]; other site
745310005431	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
745310005432	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
745310005433	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
745310005434	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
745310005435	5S rRNA interface [nucleotide binding]; other site
745310005436	23S rRNA interface [nucleotide binding]; other site
745310005437	L5 interface [polypeptide binding]; other site
745310005438	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
745310005439	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
745310005440	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
745310005441	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
745310005442	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
745310005443	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
745310005444	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
745310005445	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
745310005446	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
745310005447	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
745310005448	RNA binding site [nucleotide binding]; other site
745310005449	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
745310005450	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
745310005451	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
745310005452	23S rRNA interface [nucleotide binding]; other site
745310005453	putative translocon interaction site; other site
745310005454	signal recognition particle (SRP54) interaction site; other site
745310005455	L23 interface [polypeptide binding]; other site
745310005456	trigger factor interaction site; other site
745310005457	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
745310005458	23S rRNA interface [nucleotide binding]; other site
745310005459	5S rRNA interface [nucleotide binding]; other site
745310005460	putative antibiotic binding site [chemical binding]; other site
745310005461	L25 interface [polypeptide binding]; other site
745310005462	L27 interface [polypeptide binding]; other site
745310005463	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
745310005464	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
745310005465	G-X-X-G motif; other site
745310005466	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
745310005467	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
745310005468	putative translocon binding site; other site
745310005469	protein-rRNA interface [nucleotide binding]; other site
745310005470	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
745310005471	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
745310005472	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
745310005473	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
745310005474	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
745310005475	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
745310005476	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
745310005477	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
745310005478	elongation factor Tu; Reviewed; Region: PRK00049
745310005479	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
745310005480	G1 box; other site
745310005481	GEF interaction site [polypeptide binding]; other site
745310005482	GTP/Mg2+ binding site [chemical binding]; other site
745310005483	Switch I region; other site
745310005484	G2 box; other site
745310005485	G3 box; other site
745310005486	Switch II region; other site
745310005487	G4 box; other site
745310005488	G5 box; other site
745310005489	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
745310005490	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
745310005491	Antibiotic Binding Site [chemical binding]; other site
745310005492	elongation factor G; Reviewed; Region: PRK00007
745310005493	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
745310005494	G1 box; other site
745310005495	putative GEF interaction site [polypeptide binding]; other site
745310005496	GTP/Mg2+ binding site [chemical binding]; other site
745310005497	Switch I region; other site
745310005498	G2 box; other site
745310005499	G3 box; other site
745310005500	Switch II region; other site
745310005501	G4 box; other site
745310005502	G5 box; other site
745310005503	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
745310005504	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
745310005505	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
745310005506	30S ribosomal protein S7; Validated; Region: PRK05302
745310005507	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
745310005508	S17 interaction site [polypeptide binding]; other site
745310005509	S8 interaction site; other site
745310005510	16S rRNA interaction site [nucleotide binding]; other site
745310005511	streptomycin interaction site [chemical binding]; other site
745310005512	23S rRNA interaction site [nucleotide binding]; other site
745310005513	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
745310005514	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
745310005515	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310005516	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005517	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
745310005518	active site
745310005519	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
745310005520	active site
745310005521	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
745310005522	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
745310005523	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
745310005524	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310005525	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
745310005526	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
745310005527	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
745310005528	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
745310005529	E3 interaction surface; other site
745310005530	lipoyl attachment site [posttranslational modification]; other site
745310005531	e3 binding domain; Region: E3_binding; pfam02817
745310005532	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
745310005533	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
745310005534	GAF domain; Region: GAF_2; pfam13185
745310005535	hypothetical protein; Provisional; Region: PRK09256
745310005536	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
745310005537	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
745310005538	active site
745310005539	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
745310005540	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
745310005541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
745310005542	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
745310005543	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
745310005544	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
745310005545	Nucleoside recognition; Region: Gate; pfam07670
745310005546	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
745310005547	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
745310005548	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
745310005549	feedback inhibition sensing region; other site
745310005550	homohexameric interface [polypeptide binding]; other site
745310005551	nucleotide binding site [chemical binding]; other site
745310005552	N-acetyl-L-glutamate binding site [chemical binding]; other site
745310005553	YGGT family; Region: YGGT; pfam02325
745310005554	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
745310005555	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
745310005556	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
745310005557	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
745310005558	homodimer interface [polypeptide binding]; other site
745310005559	NADP binding site [chemical binding]; other site
745310005560	substrate binding site [chemical binding]; other site
745310005561	MarC family integral membrane protein; Region: MarC; pfam01914
745310005562	Predicted membrane protein [Function unknown]; Region: COG2246
745310005563	GtrA-like protein; Region: GtrA; pfam04138
745310005564	serine racemase; Region: PLN02970
745310005565	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
745310005566	tetramer interface [polypeptide binding]; other site
745310005567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310005568	catalytic residue [active]
745310005569	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
745310005570	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
745310005571	putative acetyltransferase; Provisional; Region: PRK03624
745310005572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310005573	Coenzyme A binding pocket [chemical binding]; other site
745310005574	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
745310005575	EamA-like transporter family; Region: EamA; pfam00892
745310005576	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
745310005577	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
745310005578	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
745310005579	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
745310005580	Acyltransferase family; Region: Acyl_transf_3; pfam01757
745310005581	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
745310005582	catalytic nucleophile [active]
745310005583	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
745310005584	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310005585	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310005586	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310005587	catalytic residue [active]
745310005588	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
745310005589	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
745310005590	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
745310005591	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310005592	putative DNA binding site [nucleotide binding]; other site
745310005593	putative Zn2+ binding site [ion binding]; other site
745310005594	AsnC family; Region: AsnC_trans_reg; pfam01037
745310005595	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310005596	LysR substrate binding domain; Region: LysR_substrate; pfam03466
745310005597	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310005598	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310005599	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
745310005600	Clp amino terminal domain; Region: Clp_N; pfam02861
745310005601	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310005602	Walker A motif; other site
745310005603	ATP binding site [chemical binding]; other site
745310005604	Walker B motif; other site
745310005605	arginine finger; other site
745310005606	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310005607	Walker A motif; other site
745310005608	ATP binding site [chemical binding]; other site
745310005609	Walker B motif; other site
745310005610	arginine finger; other site
745310005611	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
745310005612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310005613	TPR motif; other site
745310005614	binding surface
745310005615	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
745310005616	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310005617	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310005618	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310005619	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
745310005620	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
745310005621	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
745310005622	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310005623	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310005624	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310005625	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
745310005626	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310005627	DNA binding site [nucleotide binding]
745310005628	active site
745310005629	Int/Topo IB signature motif; other site
745310005630	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310005631	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
745310005632	PAS domain; Region: PAS; smart00091
745310005633	putative active site [active]
745310005634	heme pocket [chemical binding]; other site
745310005635	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310005636	DNA binding residues [nucleotide binding]
745310005637	dimerization interface [polypeptide binding]; other site
745310005638	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
745310005639	Transposase; Region: HTH_Tnp_1; pfam01527
745310005640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310005641	Integrase core domain; Region: rve; pfam00665
745310005642	Integrase core domain; Region: rve_3; pfam13683
745310005643	Restriction endonuclease [Defense mechanisms]; Region: COG3587
745310005644	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
745310005645	DNA binding site [nucleotide binding]
745310005646	active site
745310005647	Int/Topo IB signature motif; other site
745310005648	catalytic residues [active]
745310005649	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
745310005650	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
745310005651	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
745310005652	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
745310005653	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
745310005654	active site
745310005655	catalytic residues [active]
745310005656	DNA binding site [nucleotide binding]
745310005657	Int/Topo IB signature motif; other site
745310005658	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310005659	non-specific DNA binding site [nucleotide binding]; other site
745310005660	salt bridge; other site
745310005661	sequence-specific DNA binding site [nucleotide binding]; other site
745310005662	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
745310005663	HsdM N-terminal domain; Region: HsdM_N; pfam12161
745310005664	Methyltransferase domain; Region: Methyltransf_26; pfam13659
745310005665	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
745310005666	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
745310005667	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
745310005668	Abortive infection C-terminus; Region: Abi_C; pfam14355
745310005669	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
745310005670	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
745310005671	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
745310005672	ATP binding site [chemical binding]; other site
745310005673	putative Mg++ binding site [ion binding]; other site
745310005674	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
745310005675	Virulence protein [General function prediction only]; Region: COG3943
745310005676	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
745310005677	integrase; Provisional; Region: PRK09692
745310005678	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
745310005679	active site
745310005680	Int/Topo IB signature motif; other site
745310005681	AAA-like domain; Region: AAA_10; pfam12846
745310005682	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
745310005683	TraU protein; Region: TraU; pfam06834
745310005684	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
745310005685	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
745310005686	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
745310005687	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
745310005688	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
745310005689	F plasmid transfer operon protein; Region: TraF; pfam13728
745310005690	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
745310005691	catalytic residues [active]
745310005692	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
745310005693	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
745310005694	RES domain; Region: RES; pfam08808
745310005695	prevent-host-death family protein; Region: phd_fam; TIGR01552
745310005696	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
745310005697	oligomeric interface; other site
745310005698	putative active site [active]
745310005699	homodimer interface [polypeptide binding]; other site
745310005700	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
745310005701	active site
745310005702	NTP binding site [chemical binding]; other site
745310005703	metal binding triad [ion binding]; metal-binding site
745310005704	antibiotic binding site [chemical binding]; other site
745310005705	HEPN domain; Region: HEPN; cl00824
745310005706	Domain of unknown function (DUF955); Region: DUF955; pfam06114
745310005707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310005708	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310005709	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310005710	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310005711	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310005712	active site
745310005713	catalytic tetrad [active]
745310005714	Cupin; Region: Cupin_6; pfam12852
745310005715	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310005716	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310005717	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
745310005718	dinuclear metal binding motif [ion binding]; other site
745310005719	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433
745310005720	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
745310005721	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
745310005722	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
745310005723	FAD binding pocket [chemical binding]; other site
745310005724	FAD binding motif [chemical binding]; other site
745310005725	phosphate binding motif [ion binding]; other site
745310005726	beta-alpha-beta structure motif; other site
745310005727	NAD binding pocket [chemical binding]; other site
745310005728	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
745310005729	FOG: CBS domain [General function prediction only]; Region: COG0517
745310005730	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
745310005731	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
745310005732	putative active site [active]
745310005733	metal binding site [ion binding]; metal-binding site
745310005734	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
745310005735	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310005736	catalytic loop [active]
745310005737	iron binding site [ion binding]; other site
745310005738	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
745310005739	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
745310005740	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
745310005741	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
745310005742	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
745310005743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310005744	Coenzyme A binding pocket [chemical binding]; other site
745310005745	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
745310005746	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
745310005747	substrate binding pocket [chemical binding]; other site
745310005748	chain length determination region; other site
745310005749	substrate-Mg2+ binding site; other site
745310005750	catalytic residues [active]
745310005751	aspartate-rich region 1; other site
745310005752	active site lid residues [active]
745310005753	aspartate-rich region 2; other site
745310005754	chorismate mutase; Provisional; Region: PRK09239
745310005755	putative diguanylate cyclase; Provisional; Region: PRK09776
745310005756	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
745310005757	catalytic core [active]
745310005758	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
745310005759	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
745310005760	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
745310005761	catalytic core [active]
745310005762	PEP-CTERM motif; Region: VPEP; pfam07589
745310005763	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
745310005764	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310005765	active site
745310005766	nucleotide binding site [chemical binding]; other site
745310005767	HIGH motif; other site
745310005768	KMSKS motif; other site
745310005769	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
745310005770	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310005771	ATP binding site [chemical binding]; other site
745310005772	putative Mg++ binding site [ion binding]; other site
745310005773	helicase superfamily c-terminal domain; Region: HELICc; smart00490
745310005774	Helicase associated domain (HA2); Region: HA2; cl04503
745310005775	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
745310005776	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
745310005777	putative C-terminal domain interface [polypeptide binding]; other site
745310005778	putative GSH binding site (G-site) [chemical binding]; other site
745310005779	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310005780	putative dimer interface [polypeptide binding]; other site
745310005781	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310005782	N-terminal domain interface [polypeptide binding]; other site
745310005783	dimer interface [polypeptide binding]; other site
745310005784	substrate binding pocket (H-site) [chemical binding]; other site
745310005785	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
745310005786	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
745310005787	trimer interface [polypeptide binding]; other site
745310005788	active site
745310005789	substrate binding site [chemical binding]; other site
745310005790	CoA binding site [chemical binding]; other site
745310005791	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
745310005792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310005793	motif II; other site
745310005794	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
745310005795	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
745310005796	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
745310005797	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
745310005798	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310005799	catalytic residue [active]
745310005800	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
745310005801	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
745310005802	FeS assembly ATPase SufC; Region: sufC; TIGR01978
745310005803	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
745310005804	Walker A/P-loop; other site
745310005805	ATP binding site [chemical binding]; other site
745310005806	Q-loop/lid; other site
745310005807	ABC transporter signature motif; other site
745310005808	Walker B; other site
745310005809	D-loop; other site
745310005810	H-loop/switch region; other site
745310005811	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
745310005812	putative active site [active]
745310005813	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
745310005814	putative ABC transporter; Region: ycf24; CHL00085
745310005815	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
745310005816	Transcriptional regulator; Region: Rrf2; pfam02082
745310005817	Helix-turn-helix domain; Region: HTH_18; pfam12833
745310005818	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310005819	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
745310005820	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
745310005821	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
745310005822	quinone interaction residues [chemical binding]; other site
745310005823	active site
745310005824	catalytic residues [active]
745310005825	FMN binding site [chemical binding]; other site
745310005826	substrate binding site [chemical binding]; other site
745310005827	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
745310005828	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310005829	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310005830	N-terminal plug; other site
745310005831	ligand-binding site [chemical binding]; other site
745310005832	Amidohydrolase; Region: Amidohydro_5; pfam13594
745310005833	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005834	Amidohydrolase; Region: Amidohydro_4; pfam13147
745310005835	active site
745310005836	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005837	Amidohydrolase; Region: Amidohydro_5; pfam13594
745310005838	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005839	Amidohydrolase; Region: Amidohydro_4; pfam13147
745310005840	active site
745310005841	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005842	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
745310005843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310005844	putative DNA binding site [nucleotide binding]; other site
745310005845	putative Zn2+ binding site [ion binding]; other site
745310005846	AsnC family; Region: AsnC_trans_reg; pfam01037
745310005847	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
745310005848	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
745310005849	acyl-activating enzyme (AAE) consensus motif; other site
745310005850	putative AMP binding site [chemical binding]; other site
745310005851	putative active site [active]
745310005852	putative CoA binding site [chemical binding]; other site
745310005853	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
745310005854	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
745310005855	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
745310005856	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
745310005857	active site
745310005858	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
745310005859	active site
745310005860	HIGH motif; other site
745310005861	nucleotide binding site [chemical binding]; other site
745310005862	active site
745310005863	KMSKS motif; other site
745310005864	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
745310005865	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
745310005866	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
745310005867	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
745310005868	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
745310005869	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
745310005870	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
745310005871	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
745310005872	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
745310005873	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
745310005874	putative binding surface; other site
745310005875	active site
745310005876	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
745310005877	CPxP  motif; other site
745310005878	GTP-binding protein Der; Reviewed; Region: PRK00093
745310005879	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
745310005880	G1 box; other site
745310005881	GTP/Mg2+ binding site [chemical binding]; other site
745310005882	Switch I region; other site
745310005883	G2 box; other site
745310005884	Switch II region; other site
745310005885	G3 box; other site
745310005886	G4 box; other site
745310005887	G5 box; other site
745310005888	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
745310005889	G1 box; other site
745310005890	GTP/Mg2+ binding site [chemical binding]; other site
745310005891	Switch I region; other site
745310005892	G2 box; other site
745310005893	G3 box; other site
745310005894	Switch II region; other site
745310005895	G4 box; other site
745310005896	G5 box; other site
745310005897	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
745310005898	Trp docking motif [polypeptide binding]; other site
745310005899	active site
745310005900	PQQ-like domain; Region: PQQ_2; pfam13360
745310005901	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
745310005902	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
745310005903	oligomerization interface [polypeptide binding]; other site
745310005904	active site
745310005905	metal binding site [ion binding]; metal-binding site
745310005906	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
745310005907	ArsC family; Region: ArsC; pfam03960
745310005908	putative catalytic residues [active]
745310005909	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310005910	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
745310005911	C-terminal domain interface [polypeptide binding]; other site
745310005912	GSH binding site (G-site) [chemical binding]; other site
745310005913	dimer interface [polypeptide binding]; other site
745310005914	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
745310005915	N-terminal domain interface [polypeptide binding]; other site
745310005916	dimer interface [polypeptide binding]; other site
745310005917	substrate binding pocket (H-site) [chemical binding]; other site
745310005918	GMP synthase; Reviewed; Region: guaA; PRK00074
745310005919	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
745310005920	AMP/PPi binding site [chemical binding]; other site
745310005921	candidate oxyanion hole; other site
745310005922	catalytic triad [active]
745310005923	potential glutamine specificity residues [chemical binding]; other site
745310005924	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
745310005925	ATP Binding subdomain [chemical binding]; other site
745310005926	Ligand Binding sites [chemical binding]; other site
745310005927	Dimerization subdomain; other site
745310005928	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310005929	dimer interface [polypeptide binding]; other site
745310005930	putative CheW interface [polypeptide binding]; other site
745310005931	Gram-negative bacterial tonB protein; Region: TonB; cl10048
745310005932	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310005933	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310005934	N-terminal plug; other site
745310005935	ligand-binding site [chemical binding]; other site
745310005936	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310005937	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310005938	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310005939	NAD(P) binding site [chemical binding]; other site
745310005940	active site
745310005941	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
745310005942	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
745310005943	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310005944	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
745310005945	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
745310005946	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
745310005947	generic binding surface II; other site
745310005948	generic binding surface I; other site
745310005949	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
745310005950	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
745310005951	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
745310005952	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
745310005953	Uncharacterized conserved protein [Function unknown]; Region: COG3743
745310005954	Predicted permeases [General function prediction only]; Region: COG0730
745310005955	hypothetical protein; Provisional; Region: PRK10621
745310005956	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
745310005957	Domain of unknown function DUF87; Region: DUF87; pfam01935
745310005958	AAA-like domain; Region: AAA_10; pfam12846
745310005959	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
745310005960	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
745310005961	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
745310005962	aminotransferase; Validated; Region: PRK09148
745310005963	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310005964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310005965	homodimer interface [polypeptide binding]; other site
745310005966	catalytic residue [active]
745310005967	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
745310005968	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
745310005969	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
745310005970	Phasin protein; Region: Phasin_2; pfam09361
745310005971	Uncharacterized conserved protein [Function unknown]; Region: COG2127
745310005972	Surface antigen [General function prediction only]; Region: COG3942
745310005973	CHAP domain; Region: CHAP; pfam05257
745310005974	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310005975	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310005976	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
745310005977	active site
745310005978	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
745310005979	metabolite-proton symporter; Region: 2A0106; TIGR00883
745310005980	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310005981	putative substrate translocation pore; other site
745310005982	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
745310005983	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
745310005984	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
745310005985	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
745310005986	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
745310005987	D-pathway; other site
745310005988	Putative ubiquinol binding site [chemical binding]; other site
745310005989	Low-spin heme (heme b) binding site [chemical binding]; other site
745310005990	Putative water exit pathway; other site
745310005991	Binuclear center (heme o3/CuB) [ion binding]; other site
745310005992	K-pathway; other site
745310005993	Putative proton exit pathway; other site
745310005994	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
745310005995	Subunit I/III interface [polypeptide binding]; other site
745310005996	Subunit III/IV interface [polypeptide binding]; other site
745310005997	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
745310005998	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
745310005999	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310006000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310006001	dimer interface [polypeptide binding]; other site
745310006002	phosphorylation site [posttranslational modification]
745310006003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310006004	ATP binding site [chemical binding]; other site
745310006005	Mg2+ binding site [ion binding]; other site
745310006006	G-X-G motif; other site
745310006007	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
745310006008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310006009	active site
745310006010	phosphorylation site [posttranslational modification]
745310006011	intermolecular recognition site; other site
745310006012	dimerization interface [polypeptide binding]; other site
745310006013	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310006014	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
745310006015	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
745310006016	TPP-binding site; other site
745310006017	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
745310006018	PYR/PP interface [polypeptide binding]; other site
745310006019	dimer interface [polypeptide binding]; other site
745310006020	TPP binding site [chemical binding]; other site
745310006021	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
745310006022	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
745310006023	hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480
745310006024	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
745310006025	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
745310006026	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
745310006027	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
745310006028	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310006029	FeS/SAM binding site; other site
745310006030	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
745310006031	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310006032	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
745310006033	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
745310006034	active site
745310006035	hopanoid-associated phosphorylase; Region: HpnG; TIGR03468
745310006036	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
745310006037	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
745310006038	Active site cavity [active]
745310006039	catalytic acid [active]
745310006040	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310006041	squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467
745310006042	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
745310006043	active site lid residues [active]
745310006044	substrate binding pocket [chemical binding]; other site
745310006045	catalytic residues [active]
745310006046	substrate-Mg2+ binding site; other site
745310006047	aspartate-rich region 1; other site
745310006048	aspartate-rich region 2; other site
745310006049	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
745310006050	substrate binding pocket [chemical binding]; other site
745310006051	substrate-Mg2+ binding site; other site
745310006052	aspartate-rich region 1; other site
745310006053	aspartate-rich region 2; other site
745310006054	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
745310006055	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
745310006056	active site
745310006057	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
745310006058	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
745310006059	putative NADP binding site [chemical binding]; other site
745310006060	putative substrate binding site [chemical binding]; other site
745310006061	active site
745310006062	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
745310006063	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
745310006064	active site
745310006065	hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471
745310006066	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
745310006067	B12 binding site [chemical binding]; other site
745310006068	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310006069	FeS/SAM binding site; other site
745310006070	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
745310006071	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
745310006072	GTP-binding protein LepA; Provisional; Region: PRK05433
745310006073	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
745310006074	G1 box; other site
745310006075	putative GEF interaction site [polypeptide binding]; other site
745310006076	GTP/Mg2+ binding site [chemical binding]; other site
745310006077	Switch I region; other site
745310006078	G2 box; other site
745310006079	G3 box; other site
745310006080	Switch II region; other site
745310006081	G4 box; other site
745310006082	G5 box; other site
745310006083	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
745310006084	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
745310006085	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
745310006086	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
745310006087	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
745310006088	nudix motif; other site
745310006089	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
745310006090	ferredoxin-NADP+ reductase; Region: PLN02852
745310006091	Helix-turn-helix domain; Region: HTH_36; pfam13730
745310006092	HNH endonuclease; Region: HNH; pfam01844
745310006093	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
745310006094	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
745310006095	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
745310006096	Phage capsid family; Region: Phage_capsid; pfam05065
745310006097	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
745310006098	Phage-related protein [Function unknown]; Region: COG4695
745310006099	Phage portal protein; Region: Phage_portal; pfam04860
745310006100	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
745310006101	oligomerization interface [polypeptide binding]; other site
745310006102	Helix-turn-helix domain; Region: HTH_17; pfam12728
745310006103	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310006104	active site
745310006105	DNA binding site [nucleotide binding]
745310006106	Int/Topo IB signature motif; other site
745310006107	Methyltransferase domain; Region: Methyltransf_24; pfam13578
745310006108	Methyltransferase domain; Region: Methyltransf_31; pfam13847
745310006109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310006110	S-adenosylmethionine binding site [chemical binding]; other site
745310006111	peptide chain release factor 2; Provisional; Region: PRK07342
745310006112	This domain is found in peptide chain release factors; Region: PCRF; smart00937
745310006113	RF-1 domain; Region: RF-1; pfam00472
745310006114	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
745310006115	Transglycosylase; Region: Transgly; pfam00912
745310006116	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
745310006117	AMIN domain; Region: AMIN; pfam11741
745310006118	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
745310006119	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
745310006120	active site
745310006121	metal binding site [ion binding]; metal-binding site
745310006122	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
745310006123	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
745310006124	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
745310006125	Peptidase family M48; Region: Peptidase_M48; cl12018
745310006126	TPR repeat; Region: TPR_11; pfam13414
745310006127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310006128	TPR motif; other site
745310006129	binding surface
745310006130	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
745310006131	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
745310006132	catalytic residues [active]
745310006133	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
745310006134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310006135	S-adenosylmethionine binding site [chemical binding]; other site
745310006136	exopolyphosphatase; Region: exo_poly_only; TIGR03706
745310006137	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
745310006138	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
745310006139	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
745310006140	MG2 domain; Region: A2M_N; pfam01835
745310006141	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
745310006142	Alpha-2-macroglobulin family; Region: A2M; pfam00207
745310006143	Transglycosylase; Region: Transgly; pfam00912
745310006144	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
745310006145	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
745310006146	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
745310006147	active site
745310006148	intersubunit interface [polypeptide binding]; other site
745310006149	catalytic residue [active]
745310006150	phosphogluconate dehydratase; Validated; Region: PRK09054
745310006151	6-phosphogluconate dehydratase; Region: edd; TIGR01196
745310006152	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
745310006153	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
745310006154	putative active site [active]
745310006155	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
745310006156	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
745310006157	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
745310006158	multidrug efflux protein; Reviewed; Region: PRK01766
745310006159	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
745310006160	cation binding site [ion binding]; other site
745310006161	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
745310006162	glutathione S-transferase; Region: PLN02473
745310006163	putative C-terminal domain interface [polypeptide binding]; other site
745310006164	putative GSH binding site (G-site) [chemical binding]; other site
745310006165	putative dimer interface [polypeptide binding]; other site
745310006166	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
745310006167	dimer interface [polypeptide binding]; other site
745310006168	N-terminal domain interface [polypeptide binding]; other site
745310006169	putative substrate binding pocket (H-site) [chemical binding]; other site
745310006170	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
745310006171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310006172	putative substrate translocation pore; other site
745310006173	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
745310006174	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310006175	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
745310006176	FMN binding site [chemical binding]; other site
745310006177	active site
745310006178	substrate binding site [chemical binding]; other site
745310006179	catalytic residue [active]
745310006180	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
745310006181	COQ9; Region: COQ9; pfam08511
745310006182	FeoA domain; Region: FeoA; pfam04023
745310006183	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
745310006184	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
745310006185	G1 box; other site
745310006186	GTP/Mg2+ binding site [chemical binding]; other site
745310006187	Switch I region; other site
745310006188	G2 box; other site
745310006189	G3 box; other site
745310006190	Switch II region; other site
745310006191	G4 box; other site
745310006192	G5 box; other site
745310006193	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
745310006194	Nucleoside recognition; Region: Gate; pfam07670
745310006195	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
745310006196	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
745310006197	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310006198	active site
745310006199	HIGH motif; other site
745310006200	nucleotide binding site [chemical binding]; other site
745310006201	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
745310006202	active site
745310006203	KMSKS motif; other site
745310006204	NAD synthetase; Provisional; Region: PRK13981
745310006205	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
745310006206	multimer interface [polypeptide binding]; other site
745310006207	active site
745310006208	catalytic triad [active]
745310006209	protein interface 1 [polypeptide binding]; other site
745310006210	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
745310006211	homodimer interface [polypeptide binding]; other site
745310006212	NAD binding pocket [chemical binding]; other site
745310006213	ATP binding pocket [chemical binding]; other site
745310006214	Mg binding site [ion binding]; other site
745310006215	active-site loop [active]
745310006216	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
745310006217	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
745310006218	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
745310006219	active site
745310006220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
745310006221	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
745310006222	dimerization interface [polypeptide binding]; other site
745310006223	active site
745310006224	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
745310006225	putative catalytic site [active]
745310006226	putative phosphate binding site [ion binding]; other site
745310006227	active site
745310006228	metal binding site A [ion binding]; metal-binding site
745310006229	DNA binding site [nucleotide binding]
745310006230	putative AP binding site [nucleotide binding]; other site
745310006231	putative metal binding site B [ion binding]; other site
745310006232	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
745310006233	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
745310006234	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
745310006235	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
745310006236	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
745310006237	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
745310006238	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
745310006239	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
745310006240	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
745310006241	Ligand binding site; other site
745310006242	Putative Catalytic site; other site
745310006243	DXD motif; other site
745310006244	Methyltransferase domain; Region: Methyltransf_23; pfam13489
745310006245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310006246	S-adenosylmethionine binding site [chemical binding]; other site
745310006247	Acyltransferase family; Region: Acyl_transf_3; pfam01757
745310006248	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
745310006249	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
745310006250	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310006251	NAD(P) binding site [chemical binding]; other site
745310006252	active site
745310006253	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
745310006254	N-acetyltransferase; Region: Acetyltransf_2; cl00949
745310006255	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
745310006256	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
745310006257	NAD(P) binding site [chemical binding]; other site
745310006258	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310006259	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310006260	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
745310006261	Ca2+ binding site [ion binding]; other site
745310006262	argininosuccinate synthase; Provisional; Region: PRK13820
745310006263	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
745310006264	ANP binding site [chemical binding]; other site
745310006265	Substrate Binding Site II [chemical binding]; other site
745310006266	Substrate Binding Site I [chemical binding]; other site
745310006267	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
745310006268	Domain of unknown function DUF87; Region: DUF87; pfam01935
745310006269	HerA helicase [Replication, recombination, and repair]; Region: COG0433
745310006270	homoserine dehydrogenase; Provisional; Region: PRK06349
745310006271	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
745310006272	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
745310006273	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
745310006274	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
745310006275	putative active site [active]
745310006276	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
745310006277	DHH family; Region: DHH; pfam01368
745310006278	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310006279	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310006280	catalytic residues [active]
745310006281	catalytic nucleophile [active]
745310006282	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310006283	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310006284	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310006285	Synaptic Site I dimer interface [polypeptide binding]; other site
745310006286	DNA binding site [nucleotide binding]
745310006287	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310006288	DNA-binding interface [nucleotide binding]; DNA binding site
745310006289	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
745310006290	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
745310006291	Melibiase; Region: Melibiase; pfam02065
745310006292	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
745310006293	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310006294	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310006295	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
745310006296	active site
745310006297	catalytic residues [active]
745310006298	Transcriptional regulators [Transcription]; Region: FadR; COG2186
745310006299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310006300	DNA-binding site [nucleotide binding]; DNA binding site
745310006301	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
745310006302	active site
745310006303	intersubunit interface [polypeptide binding]; other site
745310006304	catalytic residue [active]
745310006305	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
745310006306	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
745310006307	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
745310006308	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
745310006309	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
745310006310	ligand binding site [chemical binding]; other site
745310006311	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
745310006312	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
745310006313	Walker A/P-loop; other site
745310006314	ATP binding site [chemical binding]; other site
745310006315	Q-loop/lid; other site
745310006316	ABC transporter signature motif; other site
745310006317	Walker B; other site
745310006318	D-loop; other site
745310006319	H-loop/switch region; other site
745310006320	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
745310006321	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
745310006322	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
745310006323	TM-ABC transporter signature motif; other site
745310006324	galactonate dehydratase; Provisional; Region: PRK14017
745310006325	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
745310006326	metal binding site [ion binding]; metal-binding site
745310006327	substrate binding pocket [chemical binding]; other site
745310006328	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310006329	classical (c) SDRs; Region: SDR_c; cd05233
745310006330	NAD(P) binding site [chemical binding]; other site
745310006331	active site
745310006332	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
745310006333	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
745310006334	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
745310006335	HflK protein; Region: hflK; TIGR01933
745310006336	HflC protein; Region: hflC; TIGR01932
745310006337	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
745310006338	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
745310006339	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
745310006340	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
745310006341	protein binding site [polypeptide binding]; other site
745310006342	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
745310006343	protein binding site [polypeptide binding]; other site
745310006344	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
745310006345	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
745310006346	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
745310006347	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
745310006348	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
745310006349	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
745310006350	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
745310006351	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
745310006352	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
745310006353	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
745310006354	active site residue [active]
745310006355	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
745310006356	active site residue [active]
745310006357	cystathionine beta-lyase; Provisional; Region: PRK09028
745310006358	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310006359	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310006360	catalytic residue [active]
745310006361	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
745310006362	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
745310006363	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
745310006364	Walker A/P-loop; other site
745310006365	ATP binding site [chemical binding]; other site
745310006366	Q-loop/lid; other site
745310006367	ABC transporter signature motif; other site
745310006368	Walker B; other site
745310006369	D-loop; other site
745310006370	H-loop/switch region; other site
745310006371	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
745310006372	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
745310006373	Walker A/P-loop; other site
745310006374	ATP binding site [chemical binding]; other site
745310006375	Q-loop/lid; other site
745310006376	ABC transporter signature motif; other site
745310006377	Walker B; other site
745310006378	D-loop; other site
745310006379	H-loop/switch region; other site
745310006380	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
745310006381	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
745310006382	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310006383	dimer interface [polypeptide binding]; other site
745310006384	conserved gate region; other site
745310006385	putative PBP binding loops; other site
745310006386	ABC-ATPase subunit interface; other site
745310006387	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
745310006388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310006389	dimer interface [polypeptide binding]; other site
745310006390	conserved gate region; other site
745310006391	putative PBP binding loops; other site
745310006392	ABC-ATPase subunit interface; other site
745310006393	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
745310006394	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
745310006395	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
745310006396	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310006397	active site
745310006398	HIGH motif; other site
745310006399	nucleotide binding site [chemical binding]; other site
745310006400	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
745310006401	active site
745310006402	KMSKS motif; other site
745310006403	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
745310006404	tRNA binding surface [nucleotide binding]; other site
745310006405	anticodon binding site; other site
745310006406	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
745310006407	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
745310006408	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
745310006409	active site
745310006410	Riboflavin kinase; Region: Flavokinase; pfam01687
745310006411	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
745310006412	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
745310006413	folate binding site [chemical binding]; other site
745310006414	NADP+ binding site [chemical binding]; other site
745310006415	thymidylate synthase; Reviewed; Region: thyA; PRK01827
745310006416	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
745310006417	dimerization interface [polypeptide binding]; other site
745310006418	active site
745310006419	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
745310006420	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
745310006421	Ligand binding site; other site
745310006422	Putative Catalytic site; other site
745310006423	DXD motif; other site
745310006424	Predicted membrane protein [Function unknown]; Region: COG2246
745310006425	GtrA-like protein; Region: GtrA; pfam04138
745310006426	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310006427	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310006428	LysR substrate binding domain; Region: LysR_substrate; pfam03466
745310006429	dimerization interface [polypeptide binding]; other site
745310006430	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310006431	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310006432	Amidohydrolase; Region: Amidohydro_4; pfam13147
745310006433	active site
745310006434	cytosine deaminase; Provisional; Region: PRK05985
745310006435	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
745310006436	active site
745310006437	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310006438	MarR family; Region: MarR; pfam01047
745310006439	MarR family; Region: MarR_2; cl17246
745310006440	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
745310006441	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310006442	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310006443	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
745310006444	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310006445	putative substrate translocation pore; other site
745310006446	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310006447	short chain dehydrogenase; Provisional; Region: PRK06180
745310006448	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310006449	NADP binding site [chemical binding]; other site
745310006450	active site
745310006451	steroid binding site; other site
745310006452	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310006453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310006454	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
745310006455	arginine:agmatin antiporter; Provisional; Region: PRK10644
745310006456	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
745310006457	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
745310006458	ornithine decarboxylase; Provisional; Region: PRK13578
745310006459	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310006460	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310006461	catalytic residue [active]
745310006462	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
745310006463	putrescine transporter; Provisional; Region: potE; PRK10655
745310006464	NRDE protein; Region: NRDE; cl01315
745310006465	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310006466	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310006467	[2Fe-2S] cluster binding site [ion binding]; other site
745310006468	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
745310006469	hydrophobic ligand binding site; other site
745310006470	enoyl-CoA hydratase; Provisional; Region: PRK08290
745310006471	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310006472	substrate binding site [chemical binding]; other site
745310006473	oxyanion hole (OAH) forming residues; other site
745310006474	trimer interface [polypeptide binding]; other site
745310006475	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310006476	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310006477	oxidoreductase; Provisional; Region: PRK12742
745310006478	classical (c) SDRs; Region: SDR_c; cd05233
745310006479	NAD(P) binding site [chemical binding]; other site
745310006480	active site
745310006481	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
745310006482	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310006483	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310006484	ligand binding site [chemical binding]; other site
745310006485	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310006486	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310006487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310006488	Transposase; Region: HTH_Tnp_1; pfam01527
745310006489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310006490	Integrase core domain; Region: rve; pfam00665
745310006491	Integrase core domain; Region: rve_3; pfam13683
745310006492	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
745310006493	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310006494	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310006495	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
745310006496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310006497	NAD(P) binding site [chemical binding]; other site
745310006498	active site
745310006499	metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123
745310006500	active site
745310006501	metal binding site [ion binding]; metal-binding site
745310006502	Dienelactone hydrolase family; Region: DLH; pfam01738
745310006503	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310006504	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
745310006505	catalytic core [active]
745310006506	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
745310006507	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
745310006508	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
745310006509	ATP-grasp domain; Region: ATP-grasp; pfam02222
745310006510	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
745310006511	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
745310006512	CoA-ligase; Region: Ligase_CoA; pfam00549
745310006513	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
745310006514	Ligand binding site [chemical binding]; other site
745310006515	Electron transfer flavoprotein domain; Region: ETF; pfam01012
745310006516	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
745310006517	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
745310006518	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
745310006519	PilZ domain; Region: PilZ; pfam07238
745310006520	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
745310006521	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
745310006522	excinuclease ABC subunit B; Provisional; Region: PRK05298
745310006523	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310006524	ATP binding site [chemical binding]; other site
745310006525	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310006526	nucleotide binding region [chemical binding]; other site
745310006527	ATP-binding site [chemical binding]; other site
745310006528	Ultra-violet resistance protein B; Region: UvrB; pfam12344
745310006529	UvrB/uvrC motif; Region: UVR; pfam02151
745310006530	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
745310006531	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310006532	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310006533	catalytic residues [active]
745310006534	catalytic nucleophile [active]
745310006535	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310006536	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310006537	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310006538	Synaptic Site I dimer interface [polypeptide binding]; other site
745310006539	DNA binding site [nucleotide binding]
745310006540	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310006541	DNA-binding interface [nucleotide binding]; DNA binding site
745310006542	potential frameshift: common BLAST hit: gi|410687270|ref|YP_006965784.1| Transposase
745310006543	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
745310006544	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
745310006545	Lipopolysaccharide-assembly; Region: LptE; pfam04390
745310006546	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
745310006547	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
745310006548	HIGH motif; other site
745310006549	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
745310006550	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310006551	active site
745310006552	KMSKS motif; other site
745310006553	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
745310006554	tRNA binding surface [nucleotide binding]; other site
745310006555	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
745310006556	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
745310006557	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
745310006558	active site
745310006559	thiamine phosphate binding site [chemical binding]; other site
745310006560	pyrophosphate binding site [ion binding]; other site
745310006561	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
745310006562	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
745310006563	catalytic residue [active]
745310006564	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
745310006565	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310006566	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
745310006567	DNA binding residues [nucleotide binding]
745310006568	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
745310006569	FecR protein; Region: FecR; pfam04773
745310006570	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310006571	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310006572	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
745310006573	Autotransporter beta-domain; Region: Autotransporter; pfam03797
745310006574	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
745310006575	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
745310006576	dimer interface [polypeptide binding]; other site
745310006577	ssDNA binding site [nucleotide binding]; other site
745310006578	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310006579	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
745310006580	ParB-like nuclease domain; Region: ParB; smart00470
745310006581	KorB domain; Region: KorB; pfam08535
745310006582	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
745310006583	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310006584	P-loop; other site
745310006585	Magnesium ion binding site [ion binding]; other site
745310006586	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310006587	Magnesium ion binding site [ion binding]; other site
745310006588	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
745310006589	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
745310006590	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
745310006591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310006592	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
745310006593	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
745310006594	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
745310006595	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
745310006596	trmE is a tRNA modification GTPase; Region: trmE; cd04164
745310006597	G1 box; other site
745310006598	GTP/Mg2+ binding site [chemical binding]; other site
745310006599	Switch I region; other site
745310006600	G2 box; other site
745310006601	Switch II region; other site
745310006602	G3 box; other site
745310006603	G4 box; other site
745310006604	G5 box; other site
745310006605	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
745310006606	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
745310006607	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
745310006608	active site
745310006609	DNA binding site [nucleotide binding]
745310006610	Dienelactone hydrolase family; Region: DLH; pfam01738
745310006611	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
745310006612	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
745310006613	NADP binding site [chemical binding]; other site
745310006614	dimer interface [polypeptide binding]; other site
745310006615	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
745310006616	transcription termination factor Rho; Provisional; Region: rho; PRK09376
745310006617	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
745310006618	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
745310006619	RNA binding site [nucleotide binding]; other site
745310006620	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
745310006621	multimer interface [polypeptide binding]; other site
745310006622	Walker A motif; other site
745310006623	ATP binding site [chemical binding]; other site
745310006624	Walker B motif; other site
745310006625	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
745310006626	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
745310006627	substrate binding site [chemical binding]; other site
745310006628	active site
745310006629	PEP synthetase regulatory protein; Provisional; Region: PRK05339
745310006630	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
745310006631	active site
745310006632	dimer interface [polypeptide binding]; other site
745310006633	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
745310006634	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
745310006635	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
745310006636	NAD(P) binding site [chemical binding]; other site
745310006637	shikimate binding site; other site
745310006638	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
745310006639	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
745310006640	CoA-binding site [chemical binding]; other site
745310006641	ATP-binding [chemical binding]; other site
745310006642	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
745310006643	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
745310006644	active site
745310006645	catalytic site [active]
745310006646	substrate binding site [chemical binding]; other site
745310006647	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
745310006648	30S subunit binding site; other site
745310006649	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
745310006650	active site
745310006651	phosphorylation site [posttranslational modification]
745310006652	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
745310006653	CoenzymeA binding site [chemical binding]; other site
745310006654	subunit interaction site [polypeptide binding]; other site
745310006655	PHB binding site; other site
745310006656	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
745310006657	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
745310006658	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
745310006659	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
745310006660	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
745310006661	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
745310006662	Cu(I) binding site [ion binding]; other site
745310006663	hypothetical protein; Provisional; Region: PRK05170
745310006664	Protein of unknown function DUF45; Region: DUF45; pfam01863
745310006665	Transglycosylase; Region: Transgly; pfam00912
745310006666	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
745310006667	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
745310006668	methionine sulfoxide reductase B; Provisional; Region: PRK00222
745310006669	SelR domain; Region: SelR; pfam01641
745310006670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
745310006671	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
745310006672	active site
745310006673	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310006674	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
745310006675	NAD(P) binding site [chemical binding]; other site
745310006676	catalytic residues [active]
745310006677	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
745310006678	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
745310006679	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
745310006680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310006681	dimer interface [polypeptide binding]; other site
745310006682	conserved gate region; other site
745310006683	putative PBP binding loops; other site
745310006684	ABC-ATPase subunit interface; other site
745310006685	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
745310006686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310006687	dimer interface [polypeptide binding]; other site
745310006688	conserved gate region; other site
745310006689	putative PBP binding loops; other site
745310006690	ABC-ATPase subunit interface; other site
745310006691	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
745310006692	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
745310006693	Walker A/P-loop; other site
745310006694	ATP binding site [chemical binding]; other site
745310006695	Q-loop/lid; other site
745310006696	ABC transporter signature motif; other site
745310006697	Walker B; other site
745310006698	D-loop; other site
745310006699	H-loop/switch region; other site
745310006700	TOBE domain; Region: TOBE_2; pfam08402
745310006701	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
745310006702	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
745310006703	catalytic triad [active]
745310006704	putative aminotransferase; Validated; Region: PRK07480
745310006705	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
745310006706	inhibitor-cofactor binding pocket; inhibition site
745310006707	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310006708	catalytic residue [active]
745310006709	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
745310006710	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
745310006711	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
745310006712	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
745310006713	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
745310006714	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
745310006715	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310006716	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
745310006717	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
745310006718	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310006719	FtsX-like permease family; Region: FtsX; pfam02687
745310006720	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310006721	FtsX-like permease family; Region: FtsX; pfam02687
745310006722	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
745310006723	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310006724	Walker A/P-loop; other site
745310006725	ATP binding site [chemical binding]; other site
745310006726	Q-loop/lid; other site
745310006727	ABC transporter signature motif; other site
745310006728	Walker B; other site
745310006729	D-loop; other site
745310006730	H-loop/switch region; other site
745310006731	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310006732	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310006733	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310006734	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
745310006735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310006736	active site
745310006737	phosphorylation site [posttranslational modification]
745310006738	intermolecular recognition site; other site
745310006739	dimerization interface [polypeptide binding]; other site
745310006740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310006741	Walker A motif; other site
745310006742	ATP binding site [chemical binding]; other site
745310006743	Walker B motif; other site
745310006744	arginine finger; other site
745310006745	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
745310006746	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310006747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310006748	ATP binding site [chemical binding]; other site
745310006749	Mg2+ binding site [ion binding]; other site
745310006750	G-X-G motif; other site
745310006751	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310006752	fumarate hydratase; Reviewed; Region: fumC; PRK00485
745310006753	Class II fumarases; Region: Fumarase_classII; cd01362
745310006754	active site
745310006755	tetramer interface [polypeptide binding]; other site
745310006756	Stringent starvation protein B; Region: SspB; pfam04386
745310006757	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
745310006758	putative active site pocket [active]
745310006759	4-fold oligomerization interface [polypeptide binding]; other site
745310006760	metal binding residues [ion binding]; metal-binding site
745310006761	3-fold/trimer interface [polypeptide binding]; other site
745310006762	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
745310006763	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
745310006764	putative active site [active]
745310006765	oxyanion strand; other site
745310006766	catalytic triad [active]
745310006767	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
745310006768	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
745310006769	catalytic residues [active]
745310006770	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
745310006771	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
745310006772	substrate binding site [chemical binding]; other site
745310006773	glutamase interaction surface [polypeptide binding]; other site
745310006774	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
745310006775	metal binding site [ion binding]; metal-binding site
745310006776	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
745310006777	nucleotide binding site/active site [active]
745310006778	HIT family signature motif; other site
745310006779	catalytic residue [active]
745310006780	amino acid transporter; Region: 2A0306; TIGR00909
745310006781	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
745310006782	prephenate dehydrogenase; Validated; Region: PRK08507
745310006783	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
745310006784	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310006785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310006786	homodimer interface [polypeptide binding]; other site
745310006787	catalytic residue [active]
745310006788	Protein of unknown function (DUF445); Region: DUF445; pfam04286
745310006789	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310006790	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310006791	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
745310006792	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310006793	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
745310006794	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
745310006795	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
745310006796	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
745310006797	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
745310006798	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
745310006799	Ligand Binding Site [chemical binding]; other site
745310006800	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
745310006801	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
745310006802	Cl binding site [ion binding]; other site
745310006803	oligomer interface [polypeptide binding]; other site
745310006804	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
745310006805	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
745310006806	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
745310006807	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
745310006808	active site
745310006809	tetramer interface; other site
745310006810	diaminopimelate decarboxylase; Region: lysA; TIGR01048
745310006811	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
745310006812	active site
745310006813	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
745310006814	substrate binding site [chemical binding]; other site
745310006815	catalytic residues [active]
745310006816	dimer interface [polypeptide binding]; other site
745310006817	argininosuccinate lyase; Provisional; Region: PRK00855
745310006818	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
745310006819	active sites [active]
745310006820	tetramer interface [polypeptide binding]; other site
745310006821	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
745310006822	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
745310006823	catalytic residues [active]
745310006824	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
745310006825	Nitrogen regulatory protein P-II; Region: P-II; smart00938
745310006826	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
745310006827	Domain of unknown function (DUF1993); Region: DUF1993; cl01567
745310006828	Putative phosphatase (DUF442); Region: DUF442; cl17385
745310006829	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
745310006830	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310006831	ATP binding site [chemical binding]; other site
745310006832	putative Mg++ binding site [ion binding]; other site
745310006833	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310006834	nucleotide binding region [chemical binding]; other site
745310006835	ATP-binding site [chemical binding]; other site
745310006836	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
745310006837	HRDC domain; Region: HRDC; pfam00570
745310006838	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
745310006839	Peptidase family M48; Region: Peptidase_M48; cl12018
745310006840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
745310006841	binding surface
745310006842	TPR motif; other site
745310006843	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310006844	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310006845	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
745310006846	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
745310006847	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
745310006848	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
745310006849	active site
745310006850	dimer interface [polypeptide binding]; other site
745310006851	motif 1; other site
745310006852	motif 2; other site
745310006853	motif 3; other site
745310006854	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
745310006855	anticodon binding site; other site
745310006856	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
745310006857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310006858	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
745310006859	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
745310006860	active site
745310006861	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
745310006862	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
745310006863	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
745310006864	dimer interface [polypeptide binding]; other site
745310006865	substrate binding site [chemical binding]; other site
745310006866	metal binding sites [ion binding]; metal-binding site
745310006867	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
745310006868	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
745310006869	dimer interface [polypeptide binding]; other site
745310006870	motif 1; other site
745310006871	active site
745310006872	motif 2; other site
745310006873	motif 3; other site
745310006874	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
745310006875	anticodon binding site; other site
745310006876	peptide chain release factor 1; Validated; Region: prfA; PRK00591
745310006877	PCRF domain; Region: PCRF; pfam03462
745310006878	RF-1 domain; Region: RF-1; pfam00472
745310006879	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
745310006880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
745310006881	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
745310006882	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
745310006883	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310006884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310006885	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
745310006886	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310006887	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
745310006888	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310006889	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
745310006890	Protein export membrane protein; Region: SecD_SecF; cl14618
745310006891	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310006892	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
745310006893	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
745310006894	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
745310006895	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
745310006896	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
745310006897	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
745310006898	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
745310006899	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310006900	aconitate hydratase; Validated; Region: PRK09277
745310006901	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
745310006902	substrate binding site [chemical binding]; other site
745310006903	ligand binding site [chemical binding]; other site
745310006904	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
745310006905	substrate binding site [chemical binding]; other site
745310006906	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
745310006907	active site
745310006908	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
745310006909	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
745310006910	Trp docking motif [polypeptide binding]; other site
745310006911	putative active site [active]
745310006912	methionine gamma-lyase; Validated; Region: PRK07049
745310006913	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
745310006914	homodimer interface [polypeptide binding]; other site
745310006915	substrate-cofactor binding pocket; other site
745310006916	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310006917	catalytic residue [active]
745310006918	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
745310006919	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310006920	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
745310006921	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310006922	putative NAD(P) binding site [chemical binding]; other site
745310006923	RNA polymerase sigma factor; Provisional; Region: PRK12511
745310006924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310006925	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310006926	DNA binding residues [nucleotide binding]
745310006927	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
745310006928	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
745310006929	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
745310006930	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310006931	substrate binding site [chemical binding]; other site
745310006932	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
745310006933	oxyanion hole (OAH) forming residues; other site
745310006934	trimer interface [polypeptide binding]; other site
745310006935	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
745310006936	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
745310006937	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
745310006938	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310006939	classical (c) SDRs; Region: SDR_c; cd05233
745310006940	NAD(P) binding site [chemical binding]; other site
745310006941	active site
745310006942	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
745310006943	classical (c) SDRs; Region: SDR_c; cd05233
745310006944	NAD(P) binding site [chemical binding]; other site
745310006945	active site
745310006946	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310006947	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310006948	active site
745310006949	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
745310006950	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
745310006951	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
745310006952	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
745310006953	Moco binding site; other site
745310006954	metal coordination site [ion binding]; other site
745310006955	maleylacetoacetate isomerase; Region: maiA; TIGR01262
745310006956	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
745310006957	C-terminal domain interface [polypeptide binding]; other site
745310006958	GSH binding site (G-site) [chemical binding]; other site
745310006959	putative dimer interface [polypeptide binding]; other site
745310006960	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
745310006961	dimer interface [polypeptide binding]; other site
745310006962	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
745310006963	N-terminal domain interface [polypeptide binding]; other site
745310006964	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310006965	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310006966	N-terminal plug; other site
745310006967	ligand-binding site [chemical binding]; other site
745310006968	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
745310006969	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
745310006970	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
745310006971	Cytochrome P450; Region: p450; cl12078
745310006972	acyl-CoA synthetase; Validated; Region: PRK09192
745310006973	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310006974	acyl-activating enzyme (AAE) consensus motif; other site
745310006975	AMP binding site [chemical binding]; other site
745310006976	active site
745310006977	CoA binding site [chemical binding]; other site
745310006978	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
745310006979	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310006980	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310006981	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310006982	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
745310006983	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
745310006984	Autotransporter beta-domain; Region: Autotransporter; pfam03797
745310006985	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
745310006986	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310006987	active site
745310006988	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310006989	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
745310006990	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
745310006991	catalytic residues [active]
745310006992	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
745310006993	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310006994	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
745310006995	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
745310006996	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
745310006997	active site
745310006998	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
745310006999	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
745310007000	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
745310007001	SLBB domain; Region: SLBB; pfam10531
745310007002	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
745310007003	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
745310007004	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
745310007005	Ligand binding site; other site
745310007006	Putative Catalytic site; other site
745310007007	DXD motif; other site
745310007008	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
745310007009	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310007010	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310007011	NAD(P) binding site [chemical binding]; other site
745310007012	active site
745310007013	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
745310007014	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
745310007015	PYR/PP interface [polypeptide binding]; other site
745310007016	dimer interface [polypeptide binding]; other site
745310007017	TPP binding site [chemical binding]; other site
745310007018	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
745310007019	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
745310007020	TPP-binding site [chemical binding]; other site
745310007021	Predicted membrane protein [Function unknown]; Region: COG2246
745310007022	GtrA-like protein; Region: GtrA; pfam04138
745310007023	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
745310007024	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
745310007025	substrate binding site; other site
745310007026	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
745310007027	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
745310007028	NAD binding site [chemical binding]; other site
745310007029	homotetramer interface [polypeptide binding]; other site
745310007030	homodimer interface [polypeptide binding]; other site
745310007031	substrate binding site [chemical binding]; other site
745310007032	active site
745310007033	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
745310007034	Uncharacterized conserved protein [Function unknown]; Region: COG5316
745310007035	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
745310007036	Uncharacterized conserved protein [Function unknown]; Region: COG5316
745310007037	Phosphotransferase enzyme family; Region: APH; pfam01636
745310007038	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
745310007039	substrate binding site [chemical binding]; other site
745310007040	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
745310007041	putative chaperone; Provisional; Region: PRK11678
745310007042	nucleotide binding site [chemical binding]; other site
745310007043	putative NEF/HSP70 interaction site [polypeptide binding]; other site
745310007044	SBD interface [polypeptide binding]; other site
745310007045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310007046	hypothetical protein; Provisional; Region: PRK07236
745310007047	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
745310007048	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310007049	PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820
745310007050	PA/protease or protease-like domain interface [polypeptide binding]; other site
745310007051	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661
745310007052	Peptidase family M28; Region: Peptidase_M28; pfam04389
745310007053	metal binding site [ion binding]; metal-binding site
745310007054	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
745310007055	homotrimer interface [polypeptide binding]; other site
745310007056	Walker A motif; other site
745310007057	GTP binding site [chemical binding]; other site
745310007058	Walker B motif; other site
745310007059	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
745310007060	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
745310007061	Transcriptional regulators [Transcription]; Region: PurR; COG1609
745310007062	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
745310007063	DNA binding site [nucleotide binding]
745310007064	domain linker motif; other site
745310007065	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
745310007066	putative dimerization interface [polypeptide binding]; other site
745310007067	putative ligand binding site [chemical binding]; other site
745310007068	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
745310007069	L-fucose transporter; Provisional; Region: PRK10133; cl17665
745310007070	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310007071	MarR family; Region: MarR; pfam01047
745310007072	Macrophage colony stimulating factor-1 (CSF-1); Region: CSF-1; pfam05337
745310007073	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310007074	Coenzyme A binding pocket [chemical binding]; other site
745310007075	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
745310007076	HPP family; Region: HPP; pfam04982
745310007077	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600
745310007078	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
745310007079	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310007080	ATP-grasp domain; Region: ATP-grasp_4; cl17255
745310007081	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
745310007082	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
745310007083	carboxyltransferase (CT) interaction site; other site
745310007084	biotinylation site [posttranslational modification]; other site
745310007085	biotin synthase; Region: bioB; TIGR00433
745310007086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310007087	FeS/SAM binding site; other site
745310007088	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
745310007089	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
745310007090	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
745310007091	homodimer interface [polypeptide binding]; other site
745310007092	substrate-cofactor binding pocket; other site
745310007093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310007094	catalytic residue [active]
745310007095	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
745310007096	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
745310007097	active site
745310007098	substrate binding site [chemical binding]; other site
745310007099	coenzyme B12 binding site [chemical binding]; other site
745310007100	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
745310007101	B12 binding site [chemical binding]; other site
745310007102	cobalt ligand [ion binding]; other site
745310007103	enoyl-CoA hydratase; Provisional; Region: PRK08140
745310007104	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310007105	substrate binding site [chemical binding]; other site
745310007106	oxyanion hole (OAH) forming residues; other site
745310007107	trimer interface [polypeptide binding]; other site
745310007108	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310007109	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
745310007110	dimer interface [polypeptide binding]; other site
745310007111	substrate binding site [chemical binding]; other site
745310007112	metal binding site [ion binding]; metal-binding site
745310007113	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
745310007114	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
745310007115	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
745310007116	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310007117	sequence-specific DNA binding site [nucleotide binding]; other site
745310007118	salt bridge; other site
745310007119	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
745310007120	Domain of unknown function (DUF955); Region: DUF955; pfam06114
745310007121	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
745310007122	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
745310007123	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
745310007124	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
745310007125	putative active site [active]
745310007126	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
745310007127	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
745310007128	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
745310007129	Ligand binding site; other site
745310007130	oligomer interface; other site
745310007131	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
745310007132	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
745310007133	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
745310007134	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
745310007135	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
745310007136	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
745310007137	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
745310007138	active site
745310007139	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
745310007140	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
745310007141	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
745310007142	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
745310007143	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
745310007144	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
745310007145	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
745310007146	ABC-2 type transporter; Region: ABC2_membrane; cl17235
745310007147	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
745310007148	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
745310007149	Walker A/P-loop; other site
745310007150	ATP binding site [chemical binding]; other site
745310007151	Q-loop/lid; other site
745310007152	ABC transporter signature motif; other site
745310007153	Walker B; other site
745310007154	D-loop; other site
745310007155	H-loop/switch region; other site
745310007156	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
745310007157	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
745310007158	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
745310007159	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
745310007160	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
745310007161	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
745310007162	Probable Catalytic site; other site
745310007163	metal-binding site
745310007164	Glucokinase; Region: Glucokinase; cl17310
745310007165	glucokinase, proteobacterial type; Region: glk; TIGR00749
745310007166	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
745310007167	homopentamer interface [polypeptide binding]; other site
745310007168	active site
745310007169	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
745310007170	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
745310007171	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
745310007172	dimerization interface [polypeptide binding]; other site
745310007173	active site
745310007174	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
745310007175	Lumazine binding domain; Region: Lum_binding; pfam00677
745310007176	Lumazine binding domain; Region: Lum_binding; pfam00677
745310007177	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
745310007178	catalytic motif [active]
745310007179	Zn binding site [ion binding]; other site
745310007180	RibD C-terminal domain; Region: RibD_C; cl17279
745310007181	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
745310007182	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310007183	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
745310007184	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
745310007185	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
745310007186	active site
745310007187	substrate binding site [chemical binding]; other site
745310007188	metal binding site [ion binding]; metal-binding site
745310007189	DnaJ chaperone protein; Provisional; Region: PTZ00100
745310007190	ATPase MipZ; Region: MipZ; pfam09140
745310007191	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310007192	P-loop; other site
745310007193	Magnesium ion binding site [ion binding]; other site
745310007194	pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380
745310007195	active site
745310007196	nucleotide binding site [chemical binding]; other site
745310007197	HIGH motif; other site
745310007198	KMSKS motif; other site
745310007199	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
745310007200	Sel1-like repeats; Region: SEL1; smart00671
745310007201	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
745310007202	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
745310007203	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
745310007204	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
745310007205	MutS domain I; Region: MutS_I; pfam01624
745310007206	MutS domain III; Region: MutS_III; pfam05192
745310007207	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
745310007208	Walker A/P-loop; other site
745310007209	ATP binding site [chemical binding]; other site
745310007210	Q-loop/lid; other site
745310007211	ABC transporter signature motif; other site
745310007212	Walker B; other site
745310007213	D-loop; other site
745310007214	H-loop/switch region; other site
745310007215	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
745310007216	Malic enzyme, N-terminal domain; Region: malic; pfam00390
745310007217	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
745310007218	putative NAD(P) binding site [chemical binding]; other site
745310007219	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
745310007220	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
745310007221	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
745310007222	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
745310007223	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
745310007224	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
745310007225	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
745310007226	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
745310007227	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
745310007228	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
745310007229	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
745310007230	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
745310007231	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
745310007232	Permease; Region: Permease; pfam02405
745310007233	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
745310007234	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
745310007235	Walker A/P-loop; other site
745310007236	ATP binding site [chemical binding]; other site
745310007237	Q-loop/lid; other site
745310007238	ABC transporter signature motif; other site
745310007239	Walker B; other site
745310007240	D-loop; other site
745310007241	H-loop/switch region; other site
745310007242	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
745310007243	mce related protein; Region: MCE; pfam02470
745310007244	Protein of unknown function (DUF330); Region: DUF330; pfam03886
745310007245	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
745310007246	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
745310007247	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
745310007248	Nitronate monooxygenase; Region: NMO; pfam03060
745310007249	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310007250	FMN binding site [chemical binding]; other site
745310007251	substrate binding site [chemical binding]; other site
745310007252	putative catalytic residue [active]
745310007253	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
745310007254	dimer interface [polypeptide binding]; other site
745310007255	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310007256	active site
745310007257	metal binding site [ion binding]; metal-binding site
745310007258	glutathione binding site [chemical binding]; other site
745310007259	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
745310007260	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310007261	active site
745310007262	phosphorylation site [posttranslational modification]
745310007263	intermolecular recognition site; other site
745310007264	dimerization interface [polypeptide binding]; other site
745310007265	LytTr DNA-binding domain; Region: LytTR; smart00850
745310007266	Histidine kinase; Region: His_kinase; pfam06580
745310007267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007268	ATP binding site [chemical binding]; other site
745310007269	Mg2+ binding site [ion binding]; other site
745310007270	G-X-G motif; other site
745310007271	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
745310007272	putative catalytic site [active]
745310007273	putative metal binding site [ion binding]; other site
745310007274	putative phosphate binding site [ion binding]; other site
745310007275	protease TldD; Provisional; Region: tldD; PRK10735
745310007276	Zinc-finger domain; Region: zf-CHCC; pfam10276
745310007277	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
745310007278	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
745310007279	Walker A/P-loop; other site
745310007280	ATP binding site [chemical binding]; other site
745310007281	Q-loop/lid; other site
745310007282	ABC transporter signature motif; other site
745310007283	Walker B; other site
745310007284	D-loop; other site
745310007285	H-loop/switch region; other site
745310007286	L-aspartate oxidase; Provisional; Region: PRK09077
745310007287	L-aspartate oxidase; Provisional; Region: PRK06175
745310007288	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
745310007289	DNA polymerase I; Provisional; Region: PRK05755
745310007290	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
745310007291	active site
745310007292	metal binding site 1 [ion binding]; metal-binding site
745310007293	putative 5' ssDNA interaction site; other site
745310007294	metal binding site 3; metal-binding site
745310007295	metal binding site 2 [ion binding]; metal-binding site
745310007296	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
745310007297	putative DNA binding site [nucleotide binding]; other site
745310007298	putative metal binding site [ion binding]; other site
745310007299	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
745310007300	active site
745310007301	catalytic site [active]
745310007302	substrate binding site [chemical binding]; other site
745310007303	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
745310007304	active site
745310007305	DNA binding site [nucleotide binding]
745310007306	catalytic site [active]
745310007307	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
745310007308	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
745310007309	dimerization interface [polypeptide binding]; other site
745310007310	DPS ferroxidase diiron center [ion binding]; other site
745310007311	ion pore; other site
745310007312	PEP-CTERM motif; Region: VPEP; pfam07589
745310007313	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
745310007314	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
745310007315	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310007316	ATP binding site [chemical binding]; other site
745310007317	putative Mg++ binding site [ion binding]; other site
745310007318	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310007319	nucleotide binding region [chemical binding]; other site
745310007320	ATP-binding site [chemical binding]; other site
745310007321	DEAD/H associated; Region: DEAD_assoc; pfam08494
745310007322	Transcriptional regulator; Region: Rrf2; cl17282
745310007323	Rrf2 family protein; Region: rrf2_super; TIGR00738
745310007324	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
745310007325	heme-binding site [chemical binding]; other site
745310007326	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310007327	classical (c) SDRs; Region: SDR_c; cd05233
745310007328	NAD(P) binding site [chemical binding]; other site
745310007329	active site
745310007330	short chain dehydrogenase; Provisional; Region: PRK06172
745310007331	classical (c) SDRs; Region: SDR_c; cd05233
745310007332	NAD(P) binding site [chemical binding]; other site
745310007333	active site
745310007334	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
745310007335	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310007336	NAD(P) binding site [chemical binding]; other site
745310007337	active site
745310007338	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
745310007339	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310007340	dimer interface [polypeptide binding]; other site
745310007341	active site
745310007342	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
745310007343	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
745310007344	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310007345	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310007346	ABC transporter; Region: ABC_tran_2; pfam12848
745310007347	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310007348	Domain of unknown function (DUF4142); Region: DUF4142; pfam13628
745310007349	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
745310007350	Protein of unknown function (DUF3175); Region: DUF3175; pfam11373
745310007351	KTSC domain; Region: KTSC; pfam13619
745310007352	short chain dehydrogenase; Provisional; Region: PRK06701
745310007353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310007354	NAD(P) binding site [chemical binding]; other site
745310007355	active site
745310007356	Protein of unknown function (DUF3897); Region: DUF3897; cl17494
745310007357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310007358	TPR motif; other site
745310007359	binding surface
745310007360	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
745310007361	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
745310007362	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
745310007363	Walker A/P-loop; other site
745310007364	ATP binding site [chemical binding]; other site
745310007365	Q-loop/lid; other site
745310007366	ABC transporter signature motif; other site
745310007367	Walker B; other site
745310007368	D-loop; other site
745310007369	H-loop/switch region; other site
745310007370	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
745310007371	Predicted membrane protein [Function unknown]; Region: COG3671
745310007372	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
745310007373	RNA methyltransferase, RsmE family; Region: TIGR00046
745310007374	CHASE4 domain; Region: CHASE4; pfam05228
745310007375	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310007376	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310007377	metal binding site [ion binding]; metal-binding site
745310007378	active site
745310007379	I-site; other site
745310007380	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310007381	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
745310007382	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
745310007383	hinge; other site
745310007384	active site
745310007385	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
745310007386	DNA-binding site [nucleotide binding]; DNA binding site
745310007387	RNA-binding motif; other site
745310007388	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
745310007389	DNA-binding site [nucleotide binding]; DNA binding site
745310007390	RNA-binding motif; other site
745310007391	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
745310007392	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
745310007393	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
745310007394	catalytic site [active]
745310007395	putative active site [active]
745310007396	putative substrate binding site [chemical binding]; other site
745310007397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
745310007398	OstA-like protein; Region: OstA; pfam03968
745310007399	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
745310007400	substrate binding site [chemical binding]; other site
745310007401	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
745310007402	ATP binding site [chemical binding]; other site
745310007403	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
745310007404	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310007405	epoxyqueuosine reductase; Region: TIGR00276
745310007406	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
745310007407	HEAT repeat; Region: HEAT; pfam02985
745310007408	potential frameshift: common BLAST hit: gi|294010294|ref|YP_003543754.1| ABC-type transport system ATPase component
745310007409	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
745310007410	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
745310007411	SelR domain; Region: SelR; pfam01641
745310007412	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
745310007413	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
745310007414	tetramer interface [polypeptide binding]; other site
745310007415	active site
745310007416	Mg2+/Mn2+ binding site [ion binding]; other site
745310007417	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
745310007418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310007419	active site
745310007420	phosphorylation site [posttranslational modification]
745310007421	intermolecular recognition site; other site
745310007422	dimerization interface [polypeptide binding]; other site
745310007423	LytTr DNA-binding domain; Region: LytTR; smart00850
745310007424	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310007425	Histidine kinase; Region: His_kinase; pfam06580
745310007426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007427	ATP binding site [chemical binding]; other site
745310007428	Mg2+ binding site [ion binding]; other site
745310007429	G-X-G motif; other site
745310007430	Response regulator receiver domain; Region: Response_reg; pfam00072
745310007431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310007432	active site
745310007433	phosphorylation site [posttranslational modification]
745310007434	intermolecular recognition site; other site
745310007435	dimerization interface [polypeptide binding]; other site
745310007436	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310007437	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310007438	metal binding site [ion binding]; metal-binding site
745310007439	active site
745310007440	I-site; other site
745310007441	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310007442	CHASE4 domain; Region: CHASE4; pfam05228
745310007443	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310007444	dimerization interface [polypeptide binding]; other site
745310007445	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310007446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007447	ATP binding site [chemical binding]; other site
745310007448	Mg2+ binding site [ion binding]; other site
745310007449	G-X-G motif; other site
745310007450	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310007451	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310007452	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
745310007453	dimerization interface [polypeptide binding]; other site
745310007454	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310007455	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310007456	[2Fe-2S] cluster binding site [ion binding]; other site
745310007457	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
745310007458	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310007459	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
745310007460	DNA binding residues [nucleotide binding]
745310007461	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
745310007462	FecR protein; Region: FecR; pfam04773
745310007463	Secretin and TonB N terminus short domain; Region: STN; smart00965
745310007464	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310007465	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007466	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007467	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310007468	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
745310007469	active site
745310007470	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
745310007471	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
745310007472	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
745310007473	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
745310007474	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
745310007475	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
745310007476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310007477	ATP-grasp domain; Region: ATP-grasp; pfam02222
745310007478	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
745310007479	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
745310007480	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
745310007481	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
745310007482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007483	Mg2+ binding site [ion binding]; other site
745310007484	G-X-G motif; other site
745310007485	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
745310007486	anchoring element; other site
745310007487	dimer interface [polypeptide binding]; other site
745310007488	ATP binding site [chemical binding]; other site
745310007489	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
745310007490	active site
745310007491	putative metal-binding site [ion binding]; other site
745310007492	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
745310007493	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
745310007494	recombination protein F; Reviewed; Region: recF; PRK00064
745310007495	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310007496	Walker A/P-loop; other site
745310007497	ATP binding site [chemical binding]; other site
745310007498	Q-loop/lid; other site
745310007499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310007500	ABC transporter signature motif; other site
745310007501	Walker B; other site
745310007502	D-loop; other site
745310007503	H-loop/switch region; other site
745310007504	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310007505	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310007506	metal binding site [ion binding]; metal-binding site
745310007507	active site
745310007508	I-site; other site
745310007509	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
745310007510	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
745310007511	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
745310007512	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
745310007513	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
745310007514	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
745310007515	Walker A/P-loop; other site
745310007516	ATP binding site [chemical binding]; other site
745310007517	Q-loop/lid; other site
745310007518	ABC transporter signature motif; other site
745310007519	Walker B; other site
745310007520	D-loop; other site
745310007521	H-loop/switch region; other site
745310007522	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
745310007523	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310007524	FeS/SAM binding site; other site
745310007525	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
745310007526	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
745310007527	DNA polymerase III subunit beta; Validated; Region: PRK05643
745310007528	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
745310007529	putative DNA binding surface [nucleotide binding]; other site
745310007530	dimer interface [polypeptide binding]; other site
745310007531	beta-clamp/clamp loader binding surface; other site
745310007532	beta-clamp/translesion DNA polymerase binding surface; other site
745310007533	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
745310007534	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
745310007535	tetramer interface [polypeptide binding]; other site
745310007536	heme binding pocket [chemical binding]; other site
745310007537	NADPH binding site [chemical binding]; other site
745310007538	Protein of unknown function (DUF2585); Region: DUF2585; pfam10755
745310007539	Lipocalin-like domain; Region: Lipocalin_5; pfam13924
745310007540	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
745310007541	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
745310007542	catalytic site [active]
745310007543	G-X2-G-X-G-K; other site
745310007544	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
745310007545	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
745310007546	Pirin-related protein [General function prediction only]; Region: COG1741
745310007547	Pirin; Region: Pirin; pfam02678
745310007548	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
745310007549	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
745310007550	domain interfaces; other site
745310007551	active site
745310007552	UGMP family protein; Validated; Region: PRK09604
745310007553	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
745310007554	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
745310007555	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
745310007556	OpgC protein; Region: OpgC_C; cl17858
745310007557	Acyltransferase family; Region: Acyl_transf_3; pfam01757
745310007558	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
745310007559	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
745310007560	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
745310007561	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
745310007562	Zn2+ binding site [ion binding]; other site
745310007563	Mg2+ binding site [ion binding]; other site
745310007564	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
745310007565	synthetase active site [active]
745310007566	NTP binding site [chemical binding]; other site
745310007567	metal binding site [ion binding]; metal-binding site
745310007568	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
745310007569	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
745310007570	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310007571	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
745310007572	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
745310007573	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
745310007574	putative active site [active]
745310007575	catalytic site [active]
745310007576	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
745310007577	PLD-like domain; Region: PLDc_2; pfam13091
745310007578	putative active site [active]
745310007579	catalytic site [active]
745310007580	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
745310007581	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
745310007582	23S rRNA binding site [nucleotide binding]; other site
745310007583	L21 binding site [polypeptide binding]; other site
745310007584	L13 binding site [polypeptide binding]; other site
745310007585	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
745310007586	GIY-YIG motif/motif A; other site
745310007587	putative active site [active]
745310007588	putative metal binding site [ion binding]; other site
745310007589	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
745310007590	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
745310007591	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
745310007592	dimer interface [polypeptide binding]; other site
745310007593	motif 1; other site
745310007594	active site
745310007595	motif 2; other site
745310007596	motif 3; other site
745310007597	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
745310007598	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
745310007599	putative tRNA-binding site [nucleotide binding]; other site
745310007600	B3/4 domain; Region: B3_4; pfam03483
745310007601	tRNA synthetase B5 domain; Region: B5; smart00874
745310007602	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
745310007603	dimer interface [polypeptide binding]; other site
745310007604	motif 1; other site
745310007605	motif 3; other site
745310007606	motif 2; other site
745310007607	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
745310007608	Peptidase family M1; Region: Peptidase_M1; pfam01433
745310007609	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
745310007610	Zn binding site [ion binding]; other site
745310007611	Domain of unknown function (DUF3358); Region: DUF3358; pfam11838
745310007612	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
745310007613	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
745310007614	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
745310007615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310007616	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
745310007617	dimerization interface [polypeptide binding]; other site
745310007618	substrate binding pocket [chemical binding]; other site
745310007619	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
745310007620	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
745310007621	active site
745310007622	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
745310007623	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
745310007624	UbiA prenyltransferase family; Region: UbiA; pfam01040
745310007625	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310007626	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
745310007627	active site
745310007628	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310007629	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007630	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007631	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310007632	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
745310007633	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
745310007634	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
745310007635	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310007636	MarR family; Region: MarR_2; pfam12802
745310007637	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
745310007638	active site
745310007639	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
745310007640	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
745310007641	DNA binding residues [nucleotide binding]
745310007642	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
745310007643	IHF dimer interface [polypeptide binding]; other site
745310007644	IHF - DNA interface [nucleotide binding]; other site
745310007645	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
745310007646	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
745310007647	dimer interface [polypeptide binding]; other site
745310007648	active site
745310007649	CoA binding pocket [chemical binding]; other site
745310007650	putative phosphate acyltransferase; Provisional; Region: PRK05331
745310007651	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
745310007652	MAPEG family; Region: MAPEG; cl09190
745310007653	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
745310007654	aminodeoxychorismate synthase; Provisional; Region: PRK07508
745310007655	chorismate binding enzyme; Region: Chorismate_bind; cl10555
745310007656	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
745310007657	substrate-cofactor binding pocket; other site
745310007658	homodimer interface [polypeptide binding]; other site
745310007659	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
745310007660	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310007661	catalytic residue [active]
745310007662	aspartate aminotransferase; Provisional; Region: PRK05764
745310007663	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310007664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310007665	homodimer interface [polypeptide binding]; other site
745310007666	catalytic residue [active]
745310007667	methionine sulfoxide reductase A; Provisional; Region: PRK13014
745310007668	pyruvate kinase; Provisional; Region: PRK06247
745310007669	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
745310007670	domain interfaces; other site
745310007671	active site
745310007672	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
745310007673	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310007674	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
745310007675	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
745310007676	active site
745310007677	PEP-CTERM motif; Region: VPEP; pfam07589
745310007678	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
745310007679	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310007680	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
745310007681	C-terminal domain interface [polypeptide binding]; other site
745310007682	GSH binding site (G-site) [chemical binding]; other site
745310007683	dimer interface [polypeptide binding]; other site
745310007684	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
745310007685	hypothetical protein; Validated; Region: PRK00110
745310007686	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
745310007687	putative active site [active]
745310007688	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
745310007689	active site
745310007690	putative DNA-binding cleft [nucleotide binding]; other site
745310007691	dimer interface [polypeptide binding]; other site
745310007692	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
745310007693	RuvA N terminal domain; Region: RuvA_N; pfam01330
745310007694	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
745310007695	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
745310007696	putative ligand binding site [chemical binding]; other site
745310007697	NAD binding site [chemical binding]; other site
745310007698	catalytic site [active]
745310007699	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310007700	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
745310007701	active site
745310007702	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
745310007703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310007704	Walker A motif; other site
745310007705	ATP binding site [chemical binding]; other site
745310007706	Walker B motif; other site
745310007707	arginine finger; other site
745310007708	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
745310007709	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
745310007710	active site
745310007711	TolQ protein; Region: tolQ; TIGR02796
745310007712	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
745310007713	TolR protein; Region: tolR; TIGR02801
745310007714	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
745310007715	TolB amino-terminal domain; Region: TolB_N; pfam04052
745310007716	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
745310007717	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
745310007718	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
745310007719	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310007720	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310007721	ligand binding site [chemical binding]; other site
745310007722	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
745310007723	active site
745310007724	Zn binding site [ion binding]; other site
745310007725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
745310007726	Protein of unknown function, DUF482; Region: DUF482; pfam04339
745310007727	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
745310007728	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
745310007729	active site
745310007730	catalytic site [active]
745310007731	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
745310007732	homotrimer interaction site [polypeptide binding]; other site
745310007733	putative active site [active]
745310007734	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
745310007735	EamA-like transporter family; Region: EamA; pfam00892
745310007736	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
745310007737	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
745310007738	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
745310007739	catalytic site [active]
745310007740	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
745310007741	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
745310007742	Response regulator receiver domain; Region: Response_reg; pfam00072
745310007743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310007744	active site
745310007745	phosphorylation site [posttranslational modification]
745310007746	intermolecular recognition site; other site
745310007747	dimerization interface [polypeptide binding]; other site
745310007748	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
745310007749	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
745310007750	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_1; cd10960
745310007751	NodB motif; other site
745310007752	putative active site [active]
745310007753	putative catalytic site [active]
745310007754	putative Zn binding site [ion binding]; other site
745310007755	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
745310007756	active site
745310007757	catalytic triad [active]
745310007758	oxyanion hole [active]
745310007759	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
745310007760	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
745310007761	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
745310007762	glucuronate isomerase; Reviewed; Region: PRK02925
745310007763	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
745310007764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310007765	D-galactonate transporter; Region: 2A0114; TIGR00893
745310007766	putative substrate translocation pore; other site
745310007767	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
745310007768	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
745310007769	putative active site pocket [active]
745310007770	putative metal binding site [ion binding]; other site
745310007771	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
745310007772	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
745310007773	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
745310007774	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
745310007775	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
745310007776	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
745310007777	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
745310007778	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
745310007779	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
745310007780	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
745310007781	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007782	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007783	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310007784	Transcriptional regulators [Transcription]; Region: PurR; COG1609
745310007785	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
745310007786	DNA binding site [nucleotide binding]
745310007787	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
745310007788	putative dimerization interface [polypeptide binding]; other site
745310007789	putative ligand binding site [chemical binding]; other site
745310007790	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
745310007791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310007792	Integrase core domain; Region: rve; pfam00665
745310007793	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310007794	Walker A motif; other site
745310007795	ATP binding site [chemical binding]; other site
745310007796	Walker B motif; other site
745310007797	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
745310007798	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
745310007799	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
745310007800	Protein of unknown function (DUF499); Region: DUF499; pfam04465
745310007801	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C_1; pfam13290
745310007802	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
745310007803	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
745310007804	active site
745310007805	NTP binding site [chemical binding]; other site
745310007806	metal binding triad [ion binding]; metal-binding site
745310007807	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
745310007808	active site
745310007809	NTP binding site [chemical binding]; other site
745310007810	metal binding triad [ion binding]; metal-binding site
745310007811	Family description; Region: UvrD_C_2; pfam13538
745310007812	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310007813	Integrase core domain; Region: rve; pfam00665
745310007814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310007815	Walker A motif; other site
745310007816	ATP binding site [chemical binding]; other site
745310007817	Walker B motif; other site
745310007818	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
745310007819	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
745310007820	active site
745310007821	substrate binding site [chemical binding]; other site
745310007822	Mg2+ binding site [ion binding]; other site
745310007823	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
745310007824	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
745310007825	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
745310007826	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
745310007827	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
745310007828	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310007829	Soluble P-type ATPase [General function prediction only]; Region: COG4087
745310007830	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
745310007831	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
745310007832	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
745310007833	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
745310007834	Ligand Binding Site [chemical binding]; other site
745310007835	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
745310007836	GAF domain; Region: GAF_3; pfam13492
745310007837	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310007838	dimer interface [polypeptide binding]; other site
745310007839	phosphorylation site [posttranslational modification]
745310007840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007841	ATP binding site [chemical binding]; other site
745310007842	Mg2+ binding site [ion binding]; other site
745310007843	G-X-G motif; other site
745310007844	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310007845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310007846	active site
745310007847	phosphorylation site [posttranslational modification]
745310007848	intermolecular recognition site; other site
745310007849	dimerization interface [polypeptide binding]; other site
745310007850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310007851	DNA binding site [nucleotide binding]
745310007852	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310007853	putative DNA binding site [nucleotide binding]; other site
745310007854	dimerization interface [polypeptide binding]; other site
745310007855	putative Zn2+ binding site [ion binding]; other site
745310007856	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
745310007857	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
745310007858	active site
745310007859	catalytic site [active]
745310007860	substrate binding site [chemical binding]; other site
745310007861	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
745310007862	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
745310007863	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310007864	active site
745310007865	DNA binding site [nucleotide binding]
745310007866	Int/Topo IB signature motif; other site
745310007867	Helix-turn-helix domain; Region: HTH_17; pfam12728
745310007868	Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250
745310007869	Terminase-like family; Region: Terminase_6; pfam03237
745310007870	Phage terminase large subunit; Region: Terminase_3; cl12054
745310007871	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310007872	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
745310007873	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
745310007874	putative active site [active]
745310007875	putative NTP binding site [chemical binding]; other site
745310007876	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
745310007877	putative nucleic acid binding site [nucleotide binding]; other site
745310007878	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310007879	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
745310007880	active site
745310007881	DNA binding site [nucleotide binding]
745310007882	Int/Topo IB signature motif; other site
745310007883	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310007884	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310007885	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310007886	catalytic residue [active]
745310007887	CHC2 zinc finger; Region: zf-CHC2; cl17510
745310007888	transposase/IS protein; Provisional; Region: PRK09183
745310007889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310007890	Walker A motif; other site
745310007891	ATP binding site [chemical binding]; other site
745310007892	Walker B motif; other site
745310007893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310007894	Integrase core domain; Region: rve; pfam00665
745310007895	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310007896	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
745310007897	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310007898	DNA binding site [nucleotide binding]
745310007899	active site
745310007900	Int/Topo IB signature motif; other site
745310007901	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310007902	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310007903	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310007904	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
745310007905	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310007906	Integrase core domain; Region: rve; pfam00665
745310007907	transposase/IS protein; Provisional; Region: PRK09183
745310007908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310007909	Walker A motif; other site
745310007910	ATP binding site [chemical binding]; other site
745310007911	Walker B motif; other site
745310007912	DEAD-like helicases superfamily; Region: DEXDc; smart00487
745310007913	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
745310007914	putative homodimer interface [polypeptide binding]; other site
745310007915	putative active site [active]
745310007916	catalytic site [active]
745310007917	Part of AAA domain; Region: AAA_19; pfam13245
745310007918	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
745310007919	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
745310007920	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
745310007921	Predicted transcriptional regulator [Transcription]; Region: COG2378
745310007922	WYL domain; Region: WYL; pfam13280
745310007923	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
745310007924	putative metal binding site [ion binding]; other site
745310007925	Uncharacterized conserved protein [Function unknown]; Region: COG1432
745310007926	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
745310007927	Catalytic GIY-YIG domain of coliphage T4 non-specific endonuclease II, type II restriction endonuclease R.Hpy188I, and similar proteins; Region: GIY-YIG_EndoII_Hpy188I_like; cd10436
745310007928	GIY-YIG motif/motif A; other site
745310007929	DNA binding site [nucleotide binding]
745310007930	active site
745310007931	catalytic site [active]
745310007932	metal binding site [ion binding]; metal-binding site
745310007933	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
745310007934	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
745310007935	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
745310007936	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
745310007937	rod shape-determining protein MreC; Provisional; Region: PRK13922
745310007938	rod shape-determining protein MreC; Region: MreC; pfam04085
745310007939	rod shape-determining protein MreB; Provisional; Region: PRK13927
745310007940	MreB and similar proteins; Region: MreB_like; cd10225
745310007941	nucleotide binding site [chemical binding]; other site
745310007942	Mg binding site [ion binding]; other site
745310007943	putative protofilament interaction site [polypeptide binding]; other site
745310007944	RodZ interaction site [polypeptide binding]; other site
745310007945	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
745310007946	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007947	ATP binding site [chemical binding]; other site
745310007948	Mg2+ binding site [ion binding]; other site
745310007949	G-X-G motif; other site
745310007950	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
745310007951	ATP binding site [chemical binding]; other site
745310007952	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
745310007953	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310007954	PAS fold; Region: PAS_3; pfam08447
745310007955	putative active site [active]
745310007956	heme pocket [chemical binding]; other site
745310007957	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310007958	PAS fold; Region: PAS_3; pfam08447
745310007959	putative active site [active]
745310007960	heme pocket [chemical binding]; other site
745310007961	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
745310007962	Histidine kinase; Region: HisKA_2; pfam07568
745310007963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310007964	ATP binding site [chemical binding]; other site
745310007965	Mg2+ binding site [ion binding]; other site
745310007966	G-X-G motif; other site
745310007967	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
745310007968	catalytic motif [active]
745310007969	Catalytic residue [active]
745310007970	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
745310007971	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
745310007972	substrate binding site [chemical binding]; other site
745310007973	catalytic Zn binding site [ion binding]; other site
745310007974	NAD binding site [chemical binding]; other site
745310007975	structural Zn binding site [ion binding]; other site
745310007976	dimer interface [polypeptide binding]; other site
745310007977	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
745310007978	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310007979	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
745310007980	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
745310007981	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
745310007982	active site
745310007983	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
745310007984	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
745310007985	active site
745310007986	(T/H)XGH motif; other site
745310007987	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
745310007988	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
745310007989	substrate binding pocket [chemical binding]; other site
745310007990	chain length determination region; other site
745310007991	substrate-Mg2+ binding site; other site
745310007992	catalytic residues [active]
745310007993	aspartate-rich region 1; other site
745310007994	active site lid residues [active]
745310007995	aspartate-rich region 2; other site
745310007996	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
745310007997	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
745310007998	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
745310007999	acyl-activating enzyme (AAE) consensus motif; other site
745310008000	putative AMP binding site [chemical binding]; other site
745310008001	putative active site [active]
745310008002	putative CoA binding site [chemical binding]; other site
745310008003	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
745310008004	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310008005	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
745310008006	putative C-terminal domain interface [polypeptide binding]; other site
745310008007	putative GSH binding site (G-site) [chemical binding]; other site
745310008008	putative dimer interface [polypeptide binding]; other site
745310008009	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310008010	N-terminal domain interface [polypeptide binding]; other site
745310008011	dimer interface [polypeptide binding]; other site
745310008012	substrate binding pocket (H-site) [chemical binding]; other site
745310008013	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
745310008014	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310008015	Amidohydrolase; Region: Amidohydro_2; pfam04909
745310008016	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
745310008017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310008018	NAD(P) binding site [chemical binding]; other site
745310008019	active site
745310008020	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
745310008021	Penicillinase repressor; Region: Pencillinase_R; pfam03965
745310008022	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
745310008023	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
745310008024	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
745310008025	ATP-grasp domain; Region: ATP-grasp_4; cl17255
745310008026	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
745310008027	putative hydrophobic ligand binding site [chemical binding]; other site
745310008028	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310008029	dimerization interface [polypeptide binding]; other site
745310008030	putative DNA binding site [nucleotide binding]; other site
745310008031	putative Zn2+ binding site [ion binding]; other site
745310008032	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
745310008033	hypothetical protein; Provisional; Region: PRK06132
745310008034	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
745310008035	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
745310008036	Uncharacterized conserved protein [Function unknown]; Region: COG3025
745310008037	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
745310008038	putative active site [active]
745310008039	putative metal binding residues [ion binding]; other site
745310008040	signature motif; other site
745310008041	putative triphosphate binding site [ion binding]; other site
745310008042	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
745310008043	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
745310008044	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
745310008045	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
745310008046	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
745310008047	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310008048	NAD binding site [chemical binding]; other site
745310008049	catalytic residues [active]
745310008050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310008051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310008052	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
745310008053	putative effector binding pocket; other site
745310008054	putative dimerization interface [polypeptide binding]; other site
745310008055	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
745310008056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
745310008057	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
745310008058	DNA binding residues [nucleotide binding]
745310008059	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
745310008060	FecR protein; Region: FecR; pfam04773
745310008061	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
745310008062	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310008063	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310008064	LysR substrate binding domain; Region: LysR_substrate; pfam03466
745310008065	dimerization interface [polypeptide binding]; other site
745310008066	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
745310008067	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
745310008068	tetrameric interface [polypeptide binding]; other site
745310008069	NAD binding site [chemical binding]; other site
745310008070	catalytic residues [active]
745310008071	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310008072	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
745310008073	substrate binding pocket [chemical binding]; other site
745310008074	FAD binding site [chemical binding]; other site
745310008075	catalytic base [active]
745310008076	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
745310008077	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310008078	substrate binding site [chemical binding]; other site
745310008079	oxyanion hole (OAH) forming residues; other site
745310008080	trimer interface [polypeptide binding]; other site
745310008081	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
745310008082	enoyl-CoA hydratase; Provisional; Region: PRK05862
745310008083	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310008084	substrate binding site [chemical binding]; other site
745310008085	oxyanion hole (OAH) forming residues; other site
745310008086	trimer interface [polypeptide binding]; other site
745310008087	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
745310008088	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
745310008089	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
745310008090	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
745310008091	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
745310008092	glucosyltransferase MdoH; Provisional; Region: PRK05454
745310008093	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
745310008094	active site
745310008095	rod shape-determining protein MreB; Provisional; Region: PRK13927
745310008096	MreB and similar proteins; Region: MreB_like; cd10225
745310008097	nucleotide binding site [chemical binding]; other site
745310008098	Mg binding site [ion binding]; other site
745310008099	putative protofilament interaction site [polypeptide binding]; other site
745310008100	RodZ interaction site [polypeptide binding]; other site
745310008101	Competence-damaged protein; Region: CinA; pfam02464
745310008102	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310008103	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
745310008104	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310008105	catalytic residue [active]
745310008106	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
745310008107	cobyric acid synthase; Provisional; Region: PRK00784
745310008108	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
745310008109	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
745310008110	catalytic triad [active]
745310008111	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
745310008112	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
745310008113	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
745310008114	active site
745310008115	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
745310008116	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
745310008117	substrate binding site [chemical binding]; other site
745310008118	ATP binding site [chemical binding]; other site
745310008119	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
745310008120	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
745310008121	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
745310008122	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310008123	NAD(P) binding site [chemical binding]; other site
745310008124	catalytic residues [active]
745310008125	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310008126	classical (c) SDRs; Region: SDR_c; cd05233
745310008127	NAD(P) binding site [chemical binding]; other site
745310008128	active site
745310008129	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
745310008130	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
745310008131	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310008132	putative substrate translocation pore; other site
745310008133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310008134	CHASE2 domain; Region: CHASE2; pfam05226
745310008135	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310008136	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310008137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310008138	metal binding site [ion binding]; metal-binding site
745310008139	active site
745310008140	I-site; other site
745310008141	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
745310008142	FAD binding domain; Region: FAD_binding_4; pfam01565
745310008143	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
745310008144	Uncharacterized conserved protein [Function unknown]; Region: COG2128
745310008145	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
745310008146	Uncharacterized conserved protein [Function unknown]; Region: COG1262
745310008147	Domain of unknown function (DUF202); Region: DUF202; pfam02656
745310008148	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
745310008149	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
745310008150	EF-hand domain pair; Region: EF_hand_5; pfam13499
745310008151	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
745310008152	EF-hand domain pair; Region: EF_hand_5; pfam13499
745310008153	Ca2+ binding site [ion binding]; other site
745310008154	EF-hand domain pair; Region: EF_hand_6; pfam13833
745310008155	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
745310008156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310008157	active site
745310008158	phosphorylation site [posttranslational modification]
745310008159	intermolecular recognition site; other site
745310008160	dimerization interface [polypeptide binding]; other site
745310008161	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310008162	DNA binding residues [nucleotide binding]
745310008163	dimerization interface [polypeptide binding]; other site
745310008164	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
745310008165	Sulfatase; Region: Sulfatase; pfam00884
745310008166	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
745310008167	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
745310008168	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
745310008169	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
745310008170	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310008171	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
745310008172	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
745310008173	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
745310008174	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
745310008175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310008176	Integrase core domain; Region: rve; pfam00665
745310008177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310008178	Walker A motif; other site
745310008179	ATP binding site [chemical binding]; other site
745310008180	Walker B motif; other site
745310008181	integrase; Provisional; Region: PRK09692
745310008182	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
745310008183	active site
745310008184	Int/Topo IB signature motif; other site
745310008185	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
745310008186	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
745310008187	putative NAD(P) binding site [chemical binding]; other site
745310008188	active site
745310008189	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
745310008190	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
745310008191	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
745310008192	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310008193	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
745310008194	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
745310008195	active site
745310008196	dimer interface [polypeptide binding]; other site
745310008197	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
745310008198	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
745310008199	active site
745310008200	FMN binding site [chemical binding]; other site
745310008201	substrate binding site [chemical binding]; other site
745310008202	3Fe-4S cluster binding site [ion binding]; other site
745310008203	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
745310008204	domain interface; other site
745310008205	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310008206	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310008207	N-terminal plug; other site
745310008208	ligand-binding site [chemical binding]; other site
745310008209	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
745310008210	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310008211	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310008212	N-terminal plug; other site
745310008213	ligand-binding site [chemical binding]; other site
745310008214	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
745310008215	Sel1-like repeats; Region: SEL1; smart00671
745310008216	Sporulation related domain; Region: SPOR; pfam05036
745310008217	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
745310008218	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310008219	P-loop; other site
745310008220	Magnesium ion binding site [ion binding]; other site
745310008221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310008222	TPR motif; other site
745310008223	binding surface
745310008224	Sporulation related domain; Region: SPOR; pfam05036
745310008225	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
745310008226	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
745310008227	enolase; Provisional; Region: eno; PRK00077
745310008228	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
745310008229	dimer interface [polypeptide binding]; other site
745310008230	metal binding site [ion binding]; metal-binding site
745310008231	substrate binding pocket [chemical binding]; other site
745310008232	Septum formation initiator; Region: DivIC; cl17659
745310008233	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
745310008234	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
745310008235	tetramer interface [polypeptide binding]; other site
745310008236	TPP-binding site [chemical binding]; other site
745310008237	heterodimer interface [polypeptide binding]; other site
745310008238	phosphorylation loop region [posttranslational modification]
745310008239	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
745310008240	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
745310008241	E3 interaction surface; other site
745310008242	lipoyl attachment site [posttranslational modification]; other site
745310008243	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
745310008244	alpha subunit interface [polypeptide binding]; other site
745310008245	TPP binding site [chemical binding]; other site
745310008246	heterodimer interface [polypeptide binding]; other site
745310008247	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
745310008248	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
745310008249	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310008250	dimer interface [polypeptide binding]; other site
745310008251	putative CheW interface [polypeptide binding]; other site
745310008252	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
745310008253	Fumarase C-terminus; Region: Fumerase_C; pfam05683
745310008254	PEP-CTERM motif; Region: VPEP; pfam07589
745310008255	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
745310008256	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
745310008257	Class I ribonucleotide reductase; Region: RNR_I; cd01679
745310008258	active site
745310008259	dimer interface [polypeptide binding]; other site
745310008260	catalytic residues [active]
745310008261	effector binding site; other site
745310008262	R2 peptide binding site; other site
745310008263	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
745310008264	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310008265	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
745310008266	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310008267	Walker A/P-loop; other site
745310008268	ATP binding site [chemical binding]; other site
745310008269	Q-loop/lid; other site
745310008270	ABC transporter signature motif; other site
745310008271	Walker B; other site
745310008272	D-loop; other site
745310008273	H-loop/switch region; other site
745310008274	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310008275	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
745310008276	FtsX-like permease family; Region: FtsX; pfam02687
745310008277	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310008278	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310008279	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008280	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310008281	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310008282	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310008283	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310008284	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310008285	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
745310008286	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
745310008287	putative substrate binding site [chemical binding]; other site
745310008288	putative ATP binding site [chemical binding]; other site
745310008289	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
745310008290	CoA-transferase family III; Region: CoA_transf_3; pfam02515
745310008291	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
745310008292	active site
745310008293	catalytic triad [active]
745310008294	oxyanion hole [active]
745310008295	switch loop; other site
745310008296	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
745310008297	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310008298	Walker A/P-loop; other site
745310008299	ATP binding site [chemical binding]; other site
745310008300	Q-loop/lid; other site
745310008301	ABC transporter signature motif; other site
745310008302	Walker B; other site
745310008303	D-loop; other site
745310008304	H-loop/switch region; other site
745310008305	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
745310008306	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
745310008307	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
745310008308	Uncharacterized conserved protein [Function unknown]; Region: COG1565
745310008309	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
745310008310	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
745310008311	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310008312	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
745310008313	acyl-activating enzyme (AAE) consensus motif; other site
745310008314	acyl-activating enzyme (AAE) consensus motif; other site
745310008315	putative AMP binding site [chemical binding]; other site
745310008316	putative active site [active]
745310008317	putative CoA binding site [chemical binding]; other site
745310008318	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310008319	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
745310008320	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
745310008321	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
745310008322	ferrochelatase; Reviewed; Region: hemH; PRK00035
745310008323	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
745310008324	C-terminal domain interface [polypeptide binding]; other site
745310008325	active site
745310008326	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
745310008327	active site
745310008328	N-terminal domain interface [polypeptide binding]; other site
745310008329	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
745310008330	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
745310008331	NAD(P) binding site [chemical binding]; other site
745310008332	homotetramer interface [polypeptide binding]; other site
745310008333	homodimer interface [polypeptide binding]; other site
745310008334	active site
745310008335	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
745310008336	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
745310008337	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310008338	N-terminal plug; other site
745310008339	ligand-binding site [chemical binding]; other site
745310008340	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
745310008341	ApbE family; Region: ApbE; pfam02424
745310008342	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
745310008343	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
745310008344	Flagellar protein FliS; Region: FliS; cl00654
745310008345	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
745310008346	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310008347	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
745310008348	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
745310008349	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
745310008350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
745310008351	Integrase core domain; Region: rve; pfam00665
745310008352	Integrase core domain; Region: rve_3; pfam13683
745310008353	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310008354	Uncharacterized conserved protein [Function unknown]; Region: COG4748
745310008355	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
745310008356	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
745310008357	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
745310008358	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
745310008359	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
745310008360	PEP-CTERM motif; Region: VPEP; pfam07589
745310008361	serine O-acetyltransferase; Region: cysE; TIGR01172
745310008362	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
745310008363	trimer interface [polypeptide binding]; other site
745310008364	active site
745310008365	substrate binding site [chemical binding]; other site
745310008366	CoA binding site [chemical binding]; other site
745310008367	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
745310008368	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
745310008369	threonine synthase; Validated; Region: PRK08197
745310008370	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
745310008371	homodimer interface [polypeptide binding]; other site
745310008372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310008373	catalytic residue [active]
745310008374	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
745310008375	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
745310008376	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
745310008377	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
745310008378	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310008379	N-terminal plug; other site
745310008380	ligand-binding site [chemical binding]; other site
745310008381	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310008382	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310008383	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
745310008384	dimerization interface [polypeptide binding]; other site
745310008385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310008386	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310008387	NAD(P) binding site [chemical binding]; other site
745310008388	active site
745310008389	Cupin; Region: Cupin_6; pfam12852
745310008390	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310008391	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310008392	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310008393	NADP binding site [chemical binding]; other site
745310008394	active site
745310008395	steroid binding site; other site
745310008396	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310008397	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310008398	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
745310008399	SnoaL-like domain; Region: SnoaL_2; pfam12680
745310008400	short chain dehydrogenase; Provisional; Region: PRK06523
745310008401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310008402	NAD(P) binding site [chemical binding]; other site
745310008403	active site
745310008404	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310008405	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
745310008406	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310008407	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310008408	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008409	short chain dehydrogenase; Provisional; Region: PRK06500
745310008410	classical (c) SDRs; Region: SDR_c; cd05233
745310008411	NAD(P) binding site [chemical binding]; other site
745310008412	active site
745310008413	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
745310008414	D-galactonate transporter; Region: 2A0114; TIGR00893
745310008415	Uncharacterized conserved protein [Function unknown]; Region: COG3189
745310008416	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
745310008417	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310008418	DNA-binding site [nucleotide binding]; DNA binding site
745310008419	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310008420	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310008421	homodimer interface [polypeptide binding]; other site
745310008422	catalytic residue [active]
745310008423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5349
745310008424	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
745310008425	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
745310008426	DNA binding residues [nucleotide binding]
745310008427	dimer interface [polypeptide binding]; other site
745310008428	[2Fe-2S] cluster binding site [ion binding]; other site
745310008429	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310008430	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008431	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cl09113
745310008432	multidrug efflux protein; Reviewed; Region: PRK09579
745310008433	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310008434	Phytase; Region: Phytase; cl17685
745310008435	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
745310008436	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
745310008437	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310008438	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310008439	Cupin-like domain; Region: Cupin_8; pfam13621
745310008440	glucose-1-dehydrogenase; Provisional; Region: PRK08936
745310008441	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
745310008442	NAD binding site [chemical binding]; other site
745310008443	homodimer interface [polypeptide binding]; other site
745310008444	active site
745310008445	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
745310008446	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310008447	Ligand Binding Site [chemical binding]; other site
745310008448	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310008449	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
745310008450	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008451	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
745310008452	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
745310008453	hydrophobic ligand binding site; other site
745310008454	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310008455	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
745310008456	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
745310008457	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310008458	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
745310008459	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
745310008460	dimerization interface [polypeptide binding]; other site
745310008461	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310008462	substrate binding pocket [chemical binding]; other site
745310008463	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
745310008464	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
745310008465	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
745310008466	VirB7 interaction site; other site
745310008467	conjugal transfer protein TrbF; Provisional; Region: PRK13872
745310008468	conjugal transfer protein TrbL; Provisional; Region: PRK13875
745310008469	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
745310008470	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
745310008471	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
745310008472	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
745310008473	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
745310008474	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
745310008475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310008476	Walker A/P-loop; other site
745310008477	ATP binding site [chemical binding]; other site
745310008478	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
745310008479	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
745310008480	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
745310008481	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
745310008482	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
745310008483	ATP binding site [chemical binding]; other site
745310008484	Walker A motif; other site
745310008485	hexamer interface [polypeptide binding]; other site
745310008486	Walker B motif; other site
745310008487	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
745310008488	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
745310008489	Walker A motif; other site
745310008490	ATP binding site [chemical binding]; other site
745310008491	Walker B motif; other site
745310008492	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
745310008493	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
745310008494	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
745310008495	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310008496	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310008497	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310008498	catalytic residue [active]
745310008499	Protein of unknown function (DUF736); Region: DUF736; pfam05284
745310008500	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
745310008501	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
745310008502	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
745310008503	Helix-turn-helix domain; Region: HTH_17; pfam12728
745310008504	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
745310008505	Domain of unknown function (DUF932); Region: DUF932; cl12129
745310008506	Uncharacterized conserved protein [Function unknown]; Region: COG5489
745310008507	ParB-like nuclease domain; Region: ParBc; pfam02195
745310008508	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
745310008509	active site
745310008510	catalytic triad [active]
745310008511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310008512	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
745310008513	Walker A motif; other site
745310008514	ATP binding site [chemical binding]; other site
745310008515	Walker B motif; other site
745310008516	arginine finger; other site
745310008517	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310008518	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
745310008519	catalytic residues [active]
745310008520	catalytic nucleophile [active]
745310008521	Recombinase; Region: Recombinase; pfam07508
745310008522	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
745310008523	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
745310008524	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
745310008525	trimer interface [polypeptide binding]; other site
745310008526	putative metal binding site [ion binding]; other site
745310008527	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
745310008528	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
745310008529	PEP-CTERM motif; Region: VPEP; pfam07589
745310008530	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
745310008531	dimer interface [polypeptide binding]; other site
745310008532	allosteric magnesium binding site [ion binding]; other site
745310008533	active site
745310008534	aspartate-rich active site metal binding site; other site
745310008535	Schiff base residues; other site
745310008536	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
745310008537	Phosphotransferase enzyme family; Region: APH; pfam01636
745310008538	putative active site [active]
745310008539	putative substrate binding site [chemical binding]; other site
745310008540	ATP binding site [chemical binding]; other site
745310008541	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
745310008542	dimer interface [polypeptide binding]; other site
745310008543	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
745310008544	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310008545	Protein of unknown function DUF72; Region: DUF72; pfam01904
745310008546	Protein of unknown function (DUF1810); Region: DUF1810; cl02370
745310008547	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
745310008548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310008549	motif II; other site
745310008550	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
745310008551	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
745310008552	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
745310008553	putative active site [active]
745310008554	Zn binding site [ion binding]; other site
745310008555	SnoaL-like domain; Region: SnoaL_3; pfam13474
745310008556	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
745310008557	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
745310008558	TadE-like protein; Region: TadE; pfam07811
745310008559	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
745310008560	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
745310008561	Ca2+ binding site [ion binding]; other site
745310008562	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
745310008563	Glucose inhibited division protein A; Region: GIDA; pfam01134
745310008564	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
745310008565	active site
745310008566	metal binding site [ion binding]; metal-binding site
745310008567	Predicted membrane protein (DUF2306); Region: DUF2306; cl02232
745310008568	Protein of unknown function, DUF488; Region: DUF488; pfam04343
745310008569	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310008570	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310008571	active site
745310008572	phosphorylation site [posttranslational modification]
745310008573	intermolecular recognition site; other site
745310008574	dimerization interface [polypeptide binding]; other site
745310008575	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310008576	DNA binding site [nucleotide binding]
745310008577	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
745310008578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
745310008579	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310008580	ATP binding site [chemical binding]; other site
745310008581	Mg2+ binding site [ion binding]; other site
745310008582	G-X-G motif; other site
745310008583	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
745310008584	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
745310008585	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310008586	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
745310008587	NAD(P) binding site [chemical binding]; other site
745310008588	catalytic residues [active]
745310008589	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
745310008590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310008591	S-adenosylmethionine binding site [chemical binding]; other site
745310008592	lysophospholipid transporter LplT; Provisional; Region: PRK11195
745310008593	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
745310008594	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
745310008595	MoaE interaction surface [polypeptide binding]; other site
745310008596	MoeB interaction surface [polypeptide binding]; other site
745310008597	thiocarboxylated glycine; other site
745310008598	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
745310008599	MoaE homodimer interface [polypeptide binding]; other site
745310008600	MoaD interaction [polypeptide binding]; other site
745310008601	active site residues [active]
745310008602	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310008603	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
745310008604	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
745310008605	active site
745310008606	dimer interface [polypeptide binding]; other site
745310008607	metal binding site [ion binding]; metal-binding site
745310008608	shikimate kinase; Provisional; Region: PRK13946
745310008609	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
745310008610	ADP binding site [chemical binding]; other site
745310008611	magnesium binding site [ion binding]; other site
745310008612	putative shikimate binding site; other site
745310008613	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
745310008614	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310008615	active site
745310008616	DNA binding site [nucleotide binding]
745310008617	Int/Topo IB signature motif; other site
745310008618	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
745310008619	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
745310008620	Peptidase family M48; Region: Peptidase_M48; cl12018
745310008621	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
745310008622	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
745310008623	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
745310008624	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
745310008625	active site
745310008626	8-oxo-dGMP binding site [chemical binding]; other site
745310008627	nudix motif; other site
745310008628	metal binding site [ion binding]; metal-binding site
745310008629	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
745310008630	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310008631	N-terminal plug; other site
745310008632	ligand-binding site [chemical binding]; other site
745310008633	SnoaL-like domain; Region: SnoaL_2; pfam12680
745310008634	Protein of unknown function, DUF481; Region: DUF481; pfam04338
745310008635	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
745310008636	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
745310008637	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
745310008638	putative active site [active]
745310008639	metal binding site [ion binding]; metal-binding site
745310008640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310008641	Integrase core domain; Region: rve; pfam00665
745310008642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310008643	Walker A motif; other site
745310008644	ATP binding site [chemical binding]; other site
745310008645	Walker B motif; other site
745310008646	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
745310008647	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
745310008648	23S rRNA interface [nucleotide binding]; other site
745310008649	L3 interface [polypeptide binding]; other site
745310008650	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
745310008651	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
745310008652	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
745310008653	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310008654	MerC mercury resistance protein; Region: MerC; pfam03203
745310008655	Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735
745310008656	metal binding site 2 [ion binding]; metal-binding site
745310008657	putative DNA binding helix; other site
745310008658	metal binding site 1 [ion binding]; metal-binding site
745310008659	dimer interface [polypeptide binding]; other site
745310008660	structural Zn2+ binding site [ion binding]; other site
745310008661	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
745310008662	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
745310008663	TPP-binding site; other site
745310008664	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
745310008665	PYR/PP interface [polypeptide binding]; other site
745310008666	dimer interface [polypeptide binding]; other site
745310008667	TPP binding site [chemical binding]; other site
745310008668	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
745310008669	TIGR02594 family protein; Region: TIGR02594
745310008670	Serine hydrolase; Region: Ser_hydrolase; pfam06821
745310008671	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310008672	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
745310008673	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310008674	RNA binding surface [nucleotide binding]; other site
745310008675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310008676	S-adenosylmethionine binding site [chemical binding]; other site
745310008677	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310008678	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310008679	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310008680	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310008681	[2Fe-2S] cluster binding site [ion binding]; other site
745310008682	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
745310008683	hydrophobic ligand binding site; other site
745310008684	Coenzyme A transferase; Region: CoA_trans; cl17247
745310008685	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
745310008686	thiamine pyrophosphate protein; Validated; Region: PRK08199
745310008687	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
745310008688	PYR/PP interface [polypeptide binding]; other site
745310008689	dimer interface [polypeptide binding]; other site
745310008690	TPP binding site [chemical binding]; other site
745310008691	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
745310008692	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
745310008693	TPP-binding site [chemical binding]; other site
745310008694	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
745310008695	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
745310008696	active site
745310008697	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
745310008698	active site
745310008699	metal-binding site
745310008700	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310008701	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
745310008702	Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520
745310008703	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
745310008704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310008705	NAD(P) binding site [chemical binding]; other site
745310008706	active site
745310008707	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
745310008708	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310008709	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310008710	putative DNA binding site [nucleotide binding]; other site
745310008711	putative Zn2+ binding site [ion binding]; other site
745310008712	NlpE N-terminal domain; Region: NlpE; pfam04170
745310008713	META domain; Region: META; pfam03724
745310008714	short chain dehydrogenase; Validated; Region: PRK06182
745310008715	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310008716	NADP binding site [chemical binding]; other site
745310008717	active site
745310008718	steroid binding site; other site
745310008719	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
745310008720	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310008721	putative substrate translocation pore; other site
745310008722	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
745310008723	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
745310008724	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310008725	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008726	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310008727	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310008728	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310008729	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
745310008730	O-Antigen ligase; Region: Wzy_C; pfam04932
745310008731	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
745310008732	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
745310008733	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
745310008734	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
745310008735	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
745310008736	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
745310008737	Predicted membrane protein/domain [Function unknown]; Region: COG1714
745310008738	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
745310008739	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
745310008740	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
745310008741	metal ion-dependent adhesion site (MIDAS); other site
745310008742	MoxR-like ATPases [General function prediction only]; Region: COG0714
745310008743	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310008744	Walker A motif; other site
745310008745	ATP binding site [chemical binding]; other site
745310008746	Walker B motif; other site
745310008747	arginine finger; other site
745310008748	aldolase II superfamily protein; Provisional; Region: PRK07044
745310008749	intersubunit interface [polypeptide binding]; other site
745310008750	active site
745310008751	Zn2+ binding site [ion binding]; other site
745310008752	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
745310008753	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
745310008754	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
745310008755	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
745310008756	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
745310008757	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
745310008758	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
745310008759	Catalytic site [active]
745310008760	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
745310008761	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
745310008762	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
745310008763	active site
745310008764	hydrophilic channel; other site
745310008765	dimerization interface [polypeptide binding]; other site
745310008766	catalytic residues [active]
745310008767	active site lid [active]
745310008768	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
745310008769	active site
745310008770	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
745310008771	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
745310008772	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
745310008773	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
745310008774	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
745310008775	Subunit I/III interface [polypeptide binding]; other site
745310008776	D-pathway; other site
745310008777	Subunit I/VIIc interface [polypeptide binding]; other site
745310008778	Subunit I/IV interface [polypeptide binding]; other site
745310008779	Subunit I/II interface [polypeptide binding]; other site
745310008780	Low-spin heme (heme a) binding site [chemical binding]; other site
745310008781	Subunit I/VIIa interface [polypeptide binding]; other site
745310008782	Subunit I/VIa interface [polypeptide binding]; other site
745310008783	Dimer interface; other site
745310008784	Putative water exit pathway; other site
745310008785	Binuclear center (heme a3/CuB) [ion binding]; other site
745310008786	K-pathway; other site
745310008787	Subunit I/Vb interface [polypeptide binding]; other site
745310008788	Putative proton exit pathway; other site
745310008789	Subunit I/VIb interface; other site
745310008790	Subunit I/VIc interface [polypeptide binding]; other site
745310008791	Electron transfer pathway; other site
745310008792	Subunit I/VIIIb interface [polypeptide binding]; other site
745310008793	Subunit I/VIIb interface [polypeptide binding]; other site
745310008794	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
745310008795	UbiA prenyltransferase family; Region: UbiA; pfam01040
745310008796	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
745310008797	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
745310008798	Subunit III/VIIa interface [polypeptide binding]; other site
745310008799	Phospholipid binding site [chemical binding]; other site
745310008800	Subunit I/III interface [polypeptide binding]; other site
745310008801	Subunit III/VIb interface [polypeptide binding]; other site
745310008802	Subunit III/VIa interface; other site
745310008803	Subunit III/Vb interface [polypeptide binding]; other site
745310008804	Protein of unknown function (DUF983); Region: DUF983; cl02211
745310008805	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
745310008806	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
745310008807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
745310008808	S-adenosylmethionine binding site [chemical binding]; other site
745310008809	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
745310008810	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
745310008811	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
745310008812	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
745310008813	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
745310008814	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310008815	catalytic residue [active]
745310008816	PAS domain S-box; Region: sensory_box; TIGR00229
745310008817	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310008818	putative active site [active]
745310008819	heme pocket [chemical binding]; other site
745310008820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
745310008821	Histidine kinase; Region: HisKA_2; pfam07568
745310008822	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310008823	ATP binding site [chemical binding]; other site
745310008824	Mg2+ binding site [ion binding]; other site
745310008825	G-X-G motif; other site
745310008826	short chain dehydrogenase; Provisional; Region: PRK06179
745310008827	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310008828	NAD(P) binding site [chemical binding]; other site
745310008829	active site
745310008830	CcmB protein; Region: CcmB; cl17444
745310008831	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
745310008832	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310008833	Walker A/P-loop; other site
745310008834	ATP binding site [chemical binding]; other site
745310008835	Q-loop/lid; other site
745310008836	ABC transporter signature motif; other site
745310008837	Walker B; other site
745310008838	D-loop; other site
745310008839	H-loop/switch region; other site
745310008840	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
745310008841	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
745310008842	aromatic arch; other site
745310008843	DCoH dimer interaction site [polypeptide binding]; other site
745310008844	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
745310008845	DCoH tetramer interaction site [polypeptide binding]; other site
745310008846	substrate binding site [chemical binding]; other site
745310008847	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
745310008848	catalytic residue [active]
745310008849	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
745310008850	Recombination protein O N terminal; Region: RecO_N; pfam11967
745310008851	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
745310008852	Prostaglandin dehydrogenases; Region: PGDH; cd05288
745310008853	NAD(P) binding site [chemical binding]; other site
745310008854	substrate binding site [chemical binding]; other site
745310008855	dimer interface [polypeptide binding]; other site
745310008856	Cupin domain; Region: Cupin_2; pfam07883
745310008857	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310008858	dimerization interface [polypeptide binding]; other site
745310008859	putative DNA binding site [nucleotide binding]; other site
745310008860	putative Zn2+ binding site [ion binding]; other site
745310008861	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
745310008862	putative hydrophobic ligand binding site [chemical binding]; other site
745310008863	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
745310008864	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
745310008865	TrkA-N domain; Region: TrkA_N; pfam02254
745310008866	putative cation:proton antiport protein; Provisional; Region: PRK10669
745310008867	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
745310008868	TrkA-N domain; Region: TrkA_N; pfam02254
745310008869	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
745310008870	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310008871	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
745310008872	iron-sulfur cluster [ion binding]; other site
745310008873	[2Fe-2S] cluster binding site [ion binding]; other site
745310008874	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310008875	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310008876	TspO/MBR family; Region: TspO_MBR; pfam03073
745310008877	Membrane fusogenic activity; Region: BMFP; pfam04380
745310008878	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
745310008879	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
745310008880	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
745310008881	ketol-acid reductoisomerase; Provisional; Region: PRK05479
745310008882	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
745310008883	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
745310008884	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
745310008885	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
745310008886	putative valine binding site [chemical binding]; other site
745310008887	dimer interface [polypeptide binding]; other site
745310008888	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
745310008889	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
745310008890	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
745310008891	PYR/PP interface [polypeptide binding]; other site
745310008892	dimer interface [polypeptide binding]; other site
745310008893	TPP binding site [chemical binding]; other site
745310008894	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
745310008895	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
745310008896	TPP-binding site [chemical binding]; other site
745310008897	dimer interface [polypeptide binding]; other site
745310008898	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
745310008899	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
745310008900	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
745310008901	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
745310008902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310008903	motif II; other site
745310008904	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
745310008905	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
745310008906	active site
745310008907	HIGH motif; other site
745310008908	nucleotide binding site [chemical binding]; other site
745310008909	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
745310008910	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
745310008911	active site
745310008912	KMSKS motif; other site
745310008913	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
745310008914	tRNA binding surface [nucleotide binding]; other site
745310008915	anticodon binding site; other site
745310008916	Protein of unknown function (DUF938); Region: DUF938; pfam06080
745310008917	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310008918	PGAP1-like protein; Region: PGAP1; pfam07819
745310008919	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
745310008920	active site
745310008921	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
745310008922	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310008923	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
745310008924	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
745310008925	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
745310008926	active site
745310008927	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
745310008928	catalytic residues [active]
745310008929	dimer interface [polypeptide binding]; other site
745310008930	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
745310008931	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310008932	dimer interface [polypeptide binding]; other site
745310008933	active site
745310008934	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
745310008935	putative active site [active]
745310008936	putative catalytic site [active]
745310008937	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
745310008938	Mechanosensitive ion channel; Region: MS_channel; pfam00924
745310008939	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
745310008940	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
745310008941	active site
745310008942	DNA binding site [nucleotide binding]
745310008943	Int/Topo IB signature motif; other site
745310008944	Predicted transcriptional regulator [Transcription]; Region: COG2932
745310008945	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
745310008946	Catalytic site [active]
745310008947	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
745310008948	Ferredoxin [Energy production and conversion]; Region: COG1146
745310008949	4Fe-4S binding domain; Region: Fer4; cl02805
745310008950	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
745310008951	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
745310008952	RNA binding surface [nucleotide binding]; other site
745310008953	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
745310008954	ATP binding site [chemical binding]; other site
745310008955	putative Mg++ binding site [ion binding]; other site
745310008956	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310008957	nucleotide binding region [chemical binding]; other site
745310008958	ATP-binding site [chemical binding]; other site
745310008959	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
745310008960	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310008961	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
745310008962	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
745310008963	Walker A/P-loop; other site
745310008964	ATP binding site [chemical binding]; other site
745310008965	Q-loop/lid; other site
745310008966	ABC transporter signature motif; other site
745310008967	Walker B; other site
745310008968	D-loop; other site
745310008969	H-loop/switch region; other site
745310008970	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
745310008971	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
745310008972	putative active site [active]
745310008973	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
745310008974	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
745310008975	putative acyl-acceptor binding pocket; other site
745310008976	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
745310008977	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
745310008978	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
745310008979	Cupin-like domain; Region: Cupin_8; pfam13621
745310008980	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
745310008981	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
745310008982	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310008983	potential frameshift: common BLAST hit: gi|315500366|ref|YP_004089169.1| tonb-dependent receptor
745310008984	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
745310008985	Transcriptional regulators [Transcription]; Region: PurR; COG1609
745310008986	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
745310008987	DNA binding site [nucleotide binding]
745310008988	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
745310008989	putative dimerization interface [polypeptide binding]; other site
745310008990	putative ligand binding site [chemical binding]; other site
745310008991	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
745310008992	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
745310008993	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
745310008994	shikimate binding site; other site
745310008995	NAD(P) binding site [chemical binding]; other site
745310008996	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
745310008997	Protein of unknown function (DUF1489); Region: DUF1489; cl11570
745310008998	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
745310008999	MgtE intracellular N domain; Region: MgtE_N; smart00924
745310009000	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
745310009001	Divalent cation transporter; Region: MgtE; cl00786
745310009002	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
745310009003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310009004	putative substrate translocation pore; other site
745310009005	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
745310009006	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310009007	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
745310009008	active site
745310009009	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
745310009010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310009011	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
745310009012	dimerization interface [polypeptide binding]; other site
745310009013	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
745310009014	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
745310009015	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
745310009016	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009017	Walker A motif; other site
745310009018	ATP binding site [chemical binding]; other site
745310009019	Walker B motif; other site
745310009020	arginine finger; other site
745310009021	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009022	Walker A motif; other site
745310009023	ATP binding site [chemical binding]; other site
745310009024	Walker B motif; other site
745310009025	arginine finger; other site
745310009026	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
745310009027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310009028	S-adenosylmethionine binding site [chemical binding]; other site
745310009029	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
745310009030	active site
745310009031	integrase; Provisional; Region: PRK09692
745310009032	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
745310009033	active site
745310009034	Int/Topo IB signature motif; other site
745310009035	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310009036	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310009037	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310009038	catalytic residue [active]
745310009039	CHC2 zinc finger; Region: zf-CHC2; cl17510
745310009040	Toprim domain; Region: Toprim_3; pfam13362
745310009041	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310009042	S-adenosylmethionine binding site [chemical binding]; other site
745310009043	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
745310009044	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
745310009045	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
745310009046	Int/Topo IB signature motif; other site
745310009047	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310009048	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
745310009049	active site
745310009050	DNA binding site [nucleotide binding]
745310009051	Int/Topo IB signature motif; other site
745310009052	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
745310009053	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
745310009054	Int/Topo IB signature motif; other site
745310009055	Helicase_C-like; Region: Helicase_C_4; pfam13871
745310009056	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
745310009057	GIY-YIG motif/motif A; other site
745310009058	active site
745310009059	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
745310009060	Uncharacterized conserved protein [Function unknown]; Region: COG2135
745310009061	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
745310009062	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
745310009063	putative active site [active]
745310009064	putative PHP Thumb interface [polypeptide binding]; other site
745310009065	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
745310009066	generic binding surface I; other site
745310009067	generic binding surface II; other site
745310009068	DNA Polymerase Y-family; Region: PolY_like; cd03468
745310009069	active site
745310009070	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
745310009071	DNA binding site [nucleotide binding]
745310009072	Uncharacterized conserved protein [Function unknown]; Region: COG4544
745310009073	CopC domain; Region: CopC; pfam04234
745310009074	Domain of unknown function (DUF305); Region: DUF305; cl17794
745310009075	Predicted metal-binding protein [General function prediction only]; Region: COG3019
745310009076	Domain of unknown function (DUF305); Region: DUF305; cl17794
745310009077	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
745310009078	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
745310009079	Multicopper oxidase; Region: Cu-oxidase; pfam00394
745310009080	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
745310009081	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310009082	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
745310009083	DNA binding residues [nucleotide binding]
745310009084	YHS domain; Region: YHS; pfam04945
745310009085	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
745310009086	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310009087	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310009088	motif II; other site
745310009089	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310009090	putative DNA binding site [nucleotide binding]; other site
745310009091	putative Zn2+ binding site [ion binding]; other site
745310009092	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
745310009093	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310009094	putative metal binding site [ion binding]; other site
745310009095	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
745310009096	ArsC family; Region: ArsC; pfam03960
745310009097	catalytic residues [active]
745310009098	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
745310009099	Sodium Bile acid symporter family; Region: SBF; cl17470
745310009100	ParB-like nuclease domain; Region: ParBc; pfam02195
745310009101	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310009102	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
745310009103	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310009104	DNA binding site [nucleotide binding]
745310009105	active site
745310009106	Int/Topo IB signature motif; other site
745310009107	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310009108	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310009109	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310009110	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
745310009111	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
745310009112	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
745310009113	dimer interface [polypeptide binding]; other site
745310009114	ssDNA binding site [nucleotide binding]; other site
745310009115	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310009116	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310009117	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
745310009118	Walker A motif; other site
745310009119	ATP binding site [chemical binding]; other site
745310009120	Walker B motif; other site
745310009121	TrwC relaxase; Region: TrwC; pfam08751
745310009122	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
745310009123	AAA domain; Region: AAA_30; pfam13604
745310009124	Predicted transcriptional regulator [Transcription]; Region: COG2932
745310009125	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
745310009126	Catalytic site [active]
745310009127	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310009128	Integrase core domain; Region: rve; pfam00665
745310009129	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009130	Walker A motif; other site
745310009131	ATP binding site [chemical binding]; other site
745310009132	Walker B motif; other site
745310009133	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
745310009134	ParB-like nuclease domain; Region: ParB; smart00470
745310009135	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310009136	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
745310009137	catalytic residues [active]
745310009138	catalytic nucleophile [active]
745310009139	Recombinase; Region: Recombinase; pfam07508
745310009140	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
745310009141	PAS domain; Region: PAS_8; pfam13188
745310009142	PAS fold; Region: PAS_4; pfam08448
745310009143	PAS domain S-box; Region: sensory_box; TIGR00229
745310009144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310009145	dimer interface [polypeptide binding]; other site
745310009146	phosphorylation site [posttranslational modification]
745310009147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310009148	ATP binding site [chemical binding]; other site
745310009149	Mg2+ binding site [ion binding]; other site
745310009150	G-X-G motif; other site
745310009151	Response regulator receiver domain; Region: Response_reg; pfam00072
745310009152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310009153	active site
745310009154	phosphorylation site [posttranslational modification]
745310009155	intermolecular recognition site; other site
745310009156	dimerization interface [polypeptide binding]; other site
745310009157	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
745310009158	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310009159	active site
745310009160	phosphorylation site [posttranslational modification]
745310009161	intermolecular recognition site; other site
745310009162	dimerization interface [polypeptide binding]; other site
745310009163	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310009164	DNA binding residues [nucleotide binding]
745310009165	dimerization interface [polypeptide binding]; other site
745310009166	Predicted transcriptional regulator [Transcription]; Region: COG1959
745310009167	Transcriptional regulator; Region: Rrf2; pfam02082
745310009168	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
745310009169	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310009170	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
745310009171	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
745310009172	homodimer interface [polypeptide binding]; other site
745310009173	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310009174	catalytic residue [active]
745310009175	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009176	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310009177	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310009178	myosin-cross-reactive antigen; Provisional; Region: PRK13977
745310009179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310009180	NAD(P) binding site [chemical binding]; other site
745310009181	active site
745310009182	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
745310009183	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
745310009184	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
745310009185	MarR family; Region: MarR_2; cl17246
745310009186	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310009187	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
745310009188	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
745310009189	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310009190	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
745310009191	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
745310009192	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310009193	dimer interface [polypeptide binding]; other site
745310009194	active site
745310009195	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
745310009196	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
745310009197	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
745310009198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310009199	NAD(P) binding site [chemical binding]; other site
745310009200	active site
745310009201	anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872
745310009202	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
745310009203	catalytic loop [active]
745310009204	iron binding site [ion binding]; other site
745310009205	Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209
745310009206	FAD binding pocket [chemical binding]; other site
745310009207	FAD binding motif [chemical binding]; other site
745310009208	phosphate binding motif [ion binding]; other site
745310009209	beta-alpha-beta structure motif; other site
745310009210	NAD binding pocket [chemical binding]; other site
745310009211	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
745310009212	inter-subunit interface; other site
745310009213	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
745310009214	Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542
745310009215	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
745310009216	putative alpha subunit interface [polypeptide binding]; other site
745310009217	putative active site [active]
745310009218	putative substrate binding site [chemical binding]; other site
745310009219	Fe binding site [ion binding]; other site
745310009220	catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439
745310009221	Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460
745310009222	dimer interface [polypeptide binding]; other site
745310009223	active site
745310009224	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
745310009225	Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318
745310009226	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
745310009227	octamer interface [polypeptide binding]; other site
745310009228	active site
745310009229	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
745310009230	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310009231	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445
745310009232	dimerizarion interface [polypeptide binding]; other site
745310009233	CrgA pocket; other site
745310009234	substrate binding pocket [chemical binding]; other site
745310009235	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
745310009236	active site
745310009237	nucleophile elbow; other site
745310009238	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
745310009239	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310009240	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310009241	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
745310009242	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310009243	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
745310009244	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
745310009245	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
745310009246	PA/protease or protease-like domain interface [polypeptide binding]; other site
745310009247	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
745310009248	metal binding site [ion binding]; metal-binding site
745310009249	PilZ domain; Region: PilZ; pfam07238
745310009250	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310009251	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310009252	metal binding site [ion binding]; metal-binding site
745310009253	active site
745310009254	I-site; other site
745310009255	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
745310009256	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310009257	catalytic residue [active]
745310009258	EamA-like transporter family; Region: EamA; pfam00892
745310009259	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
745310009260	EamA-like transporter family; Region: EamA; pfam00892
745310009261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310009262	NAD(P) binding site [chemical binding]; other site
745310009263	active site
745310009264	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310009265	aminopeptidase N; Provisional; Region: pepN; PRK14015
745310009266	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
745310009267	active site
745310009268	Zn binding site [ion binding]; other site
745310009269	Cation efflux family; Region: Cation_efflux; cl00316
745310009270	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
745310009271	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
745310009272	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
745310009273	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
745310009274	PEP-CTERM motif; Region: VPEP; pfam07589
745310009275	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
745310009276	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
745310009277	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
745310009278	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
745310009279	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
745310009280	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
745310009281	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
745310009282	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
745310009283	HSP70 interaction site [polypeptide binding]; other site
745310009284	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
745310009285	substrate binding site [polypeptide binding]; other site
745310009286	dimer interface [polypeptide binding]; other site
745310009287	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
745310009288	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
745310009289	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
745310009290	NAD binding site [chemical binding]; other site
745310009291	homotetramer interface [polypeptide binding]; other site
745310009292	homodimer interface [polypeptide binding]; other site
745310009293	substrate binding site [chemical binding]; other site
745310009294	active site
745310009295	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
745310009296	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
745310009297	Tetramer interface [polypeptide binding]; other site
745310009298	active site
745310009299	FMN-binding site [chemical binding]; other site
745310009300	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
745310009301	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
745310009302	CAP-like domain; other site
745310009303	active site
745310009304	primary dimer interface [polypeptide binding]; other site
745310009305	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310009306	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310009307	metal binding site [ion binding]; metal-binding site
745310009308	active site
745310009309	I-site; other site
745310009310	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310009311	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
745310009312	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
745310009313	active site
745310009314	NTP binding site [chemical binding]; other site
745310009315	metal binding triad [ion binding]; metal-binding site
745310009316	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
745310009317	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
745310009318	putative active site [active]
745310009319	putative CoA binding site [chemical binding]; other site
745310009320	nudix motif; other site
745310009321	metal binding site [ion binding]; metal-binding site
745310009322	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
745310009323	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
745310009324	Predicted acetyltransferase [General function prediction only]; Region: COG3153
745310009325	Dihydroneopterin aldolase; Region: FolB; smart00905
745310009326	active site
745310009327	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
745310009328	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
745310009329	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
745310009330	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
745310009331	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
745310009332	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
745310009333	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
745310009334	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
745310009335	ATP binding site [chemical binding]; other site
745310009336	substrate interface [chemical binding]; other site
745310009337	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
745310009338	trimer interface [polypeptide binding]; other site
745310009339	active site
745310009340	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
745310009341	intracellular protease, PfpI family; Region: PfpI; TIGR01382
745310009342	potential catalytic triad [active]
745310009343	conserved cys residue [active]
745310009344	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
745310009345	Flavoprotein; Region: Flavoprotein; pfam02441
745310009346	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
745310009347	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
745310009348	ABC1 family; Region: ABC1; cl17513
745310009349	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
745310009350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310009351	S-adenosylmethionine binding site [chemical binding]; other site
745310009352	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
745310009353	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
745310009354	DNA binding site [nucleotide binding]
745310009355	catalytic residue [active]
745310009356	H2TH interface [polypeptide binding]; other site
745310009357	putative catalytic residues [active]
745310009358	turnover-facilitating residue; other site
745310009359	intercalation triad [nucleotide binding]; other site
745310009360	8OG recognition residue [nucleotide binding]; other site
745310009361	putative reading head residues; other site
745310009362	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
745310009363	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
745310009364	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
745310009365	DnaA N-terminal domain; Region: DnaA_N; pfam11638
745310009366	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
745310009367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009368	Walker B motif; other site
745310009369	arginine finger; other site
745310009370	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
745310009371	DnaA box-binding interface [nucleotide binding]; other site
745310009372	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
745310009373	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
745310009374	active site
745310009375	HIGH motif; other site
745310009376	dimer interface [polypeptide binding]; other site
745310009377	KMSKS motif; other site
745310009378	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
745310009379	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
745310009380	Preprotein translocase subunit SecB; Region: SecB; pfam02556
745310009381	SecA binding site; other site
745310009382	Preprotein binding site; other site
745310009383	Tim44-like domain; Region: Tim44; pfam04280
745310009384	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
745310009385	MltA specific insert domain; Region: MltA; smart00925
745310009386	3D domain; Region: 3D; pfam06725
745310009387	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310009388	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310009389	metal binding site [ion binding]; metal-binding site
745310009390	active site
745310009391	I-site; other site
745310009392	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310009393	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
745310009394	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
745310009395	metal binding site [ion binding]; metal-binding site
745310009396	dimer interface [polypeptide binding]; other site
745310009397	Cupin domain; Region: Cupin_2; cl17218
745310009398	glutathione S-transferase; Provisional; Region: PRK15113
745310009399	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
745310009400	putative C-terminal domain interface [polypeptide binding]; other site
745310009401	putative GSH binding site (G-site) [chemical binding]; other site
745310009402	putative dimer interface [polypeptide binding]; other site
745310009403	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
745310009404	putative substrate binding pocket (H-site) [chemical binding]; other site
745310009405	putative N-terminal domain interface [polypeptide binding]; other site
745310009406	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
745310009407	G1 box; other site
745310009408	GTP/Mg2+ binding site [chemical binding]; other site
745310009409	Switch I region; other site
745310009410	G2 box; other site
745310009411	G3 box; other site
745310009412	Switch II region; other site
745310009413	G4 box; other site
745310009414	G5 box; other site
745310009415	membrane protein insertase; Provisional; Region: PRK01318
745310009416	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
745310009417	Haemolytic domain; Region: Haemolytic; pfam01809
745310009418	Ribonuclease P; Region: Ribonuclease_P; pfam00825
745310009419	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
745310009420	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
745310009421	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
745310009422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009423	Walker A motif; other site
745310009424	ATP binding site [chemical binding]; other site
745310009425	Walker B motif; other site
745310009426	arginine finger; other site
745310009427	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
745310009428	Protein of unknown function (DUF805); Region: DUF805; pfam05656
745310009429	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
745310009430	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
745310009431	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
745310009432	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
745310009433	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
745310009434	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
745310009435	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
745310009436	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
745310009437	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
745310009438	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
745310009439	GatB domain; Region: GatB_Yqey; smart00845
745310009440	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
745310009441	BolA-like protein; Region: BolA; pfam01722
745310009442	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
745310009443	putative GSH binding site [chemical binding]; other site
745310009444	catalytic residues [active]
745310009445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310009446	non-specific DNA binding site [nucleotide binding]; other site
745310009447	salt bridge; other site
745310009448	sequence-specific DNA binding site [nucleotide binding]; other site
745310009449	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
745310009450	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
745310009451	quinolinate synthetase; Provisional; Region: PRK09375
745310009452	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
745310009453	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
745310009454	dimerization interface [polypeptide binding]; other site
745310009455	active site
745310009456	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
745310009457	B1 nucleotide binding pocket [chemical binding]; other site
745310009458	B2 nucleotide binding pocket [chemical binding]; other site
745310009459	CAS motifs; other site
745310009460	active site
745310009461	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
745310009462	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
745310009463	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
745310009464	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
745310009465	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
745310009466	peptide binding site [polypeptide binding]; other site
745310009467	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
745310009468	IHF dimer interface [polypeptide binding]; other site
745310009469	IHF - DNA interface [nucleotide binding]; other site
745310009470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310009471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009472	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310009473	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009474	N-terminal plug; other site
745310009475	ligand-binding site [chemical binding]; other site
745310009476	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
745310009477	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
745310009478	active site
745310009479	metal binding site [ion binding]; metal-binding site
745310009480	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310009481	classical (c) SDRs; Region: SDR_c; cd05233
745310009482	NAD(P) binding site [chemical binding]; other site
745310009483	active site
745310009484	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
745310009485	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
745310009486	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310009487	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009488	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
745310009489	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
745310009490	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310009491	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009492	N-terminal plug; other site
745310009493	ligand-binding site [chemical binding]; other site
745310009494	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
745310009495	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
745310009496	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
745310009497	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
745310009498	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
745310009499	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
745310009500	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
745310009501	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
745310009502	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
745310009503	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
745310009504	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
745310009505	homodimer interface [polypeptide binding]; other site
745310009506	Walker A motif; other site
745310009507	ATP binding site [chemical binding]; other site
745310009508	hydroxycobalamin binding site [chemical binding]; other site
745310009509	Walker B motif; other site
745310009510	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
745310009511	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
745310009512	intersubunit interface [polypeptide binding]; other site
745310009513	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
745310009514	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310009515	active site
745310009516	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
745310009517	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
745310009518	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
745310009519	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
745310009520	IHF dimer interface [polypeptide binding]; other site
745310009521	IHF - DNA interface [nucleotide binding]; other site
745310009522	Cytochrome c; Region: Cytochrom_C; cl11414
745310009523	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
745310009524	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
745310009525	RNA binding site [nucleotide binding]; other site
745310009526	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
745310009527	RNA binding site [nucleotide binding]; other site
745310009528	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
745310009529	RNA binding site [nucleotide binding]; other site
745310009530	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
745310009531	RNA binding site [nucleotide binding]; other site
745310009532	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
745310009533	RNA binding site [nucleotide binding]; other site
745310009534	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
745310009535	RNA binding site [nucleotide binding]; other site
745310009536	cytidylate kinase; Provisional; Region: cmk; PRK00023
745310009537	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
745310009538	CMP-binding site; other site
745310009539	The sites determining sugar specificity; other site
745310009540	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
745310009541	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
745310009542	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
745310009543	hinge; other site
745310009544	active site
745310009545	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
745310009546	TIGR02300 family protein; Region: FYDLN_acid
745310009547	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
745310009548	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310009549	putative DNA binding site [nucleotide binding]; other site
745310009550	putative Zn2+ binding site [ion binding]; other site
745310009551	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310009552	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
745310009553	NAD(P) binding site [chemical binding]; other site
745310009554	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
745310009555	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
745310009556	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310009557	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310009558	active site
745310009559	catalytic tetrad [active]
745310009560	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
745310009561	TrbC/VIRB2 family; Region: TrbC; pfam04956
745310009562	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009563	N-terminal plug; other site
745310009564	ligand-binding site [chemical binding]; other site
745310009565	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
745310009566	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
745310009567	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
745310009568	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
745310009569	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310009570	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
745310009571	NADP binding site [chemical binding]; other site
745310009572	dimer interface [polypeptide binding]; other site
745310009573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310009574	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009575	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
745310009576	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
745310009577	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310009578	Walker A/P-loop; other site
745310009579	ATP binding site [chemical binding]; other site
745310009580	Q-loop/lid; other site
745310009581	ABC transporter signature motif; other site
745310009582	Walker B; other site
745310009583	D-loop; other site
745310009584	H-loop/switch region; other site
745310009585	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
745310009586	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
745310009587	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310009588	Walker A/P-loop; other site
745310009589	ATP binding site [chemical binding]; other site
745310009590	Q-loop/lid; other site
745310009591	ABC transporter signature motif; other site
745310009592	Walker B; other site
745310009593	D-loop; other site
745310009594	H-loop/switch region; other site
745310009595	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
745310009596	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
745310009597	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
745310009598	active site
745310009599	non-prolyl cis peptide bond; other site
745310009600	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
745310009601	active site
745310009602	Zn2+ binding site [ion binding]; other site
745310009603	intersubunit interface [polypeptide binding]; other site
745310009604	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
745310009605	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
745310009606	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
745310009607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009608	Walker A motif; other site
745310009609	ATP binding site [chemical binding]; other site
745310009610	Walker B motif; other site
745310009611	arginine finger; other site
745310009612	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
745310009613	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
745310009614	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
745310009615	substrate binding pocket [chemical binding]; other site
745310009616	membrane-bound complex binding site; other site
745310009617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
745310009618	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
745310009619	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
745310009620	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310009621	dimer interface [polypeptide binding]; other site
745310009622	conserved gate region; other site
745310009623	putative PBP binding loops; other site
745310009624	ABC-ATPase subunit interface; other site
745310009625	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
745310009626	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
745310009627	Walker A/P-loop; other site
745310009628	ATP binding site [chemical binding]; other site
745310009629	Q-loop/lid; other site
745310009630	ABC transporter signature motif; other site
745310009631	Walker B; other site
745310009632	D-loop; other site
745310009633	H-loop/switch region; other site
745310009634	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
745310009635	putative FMN binding site [chemical binding]; other site
745310009636	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310009637	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
745310009638	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
745310009639	active site
745310009640	dimer interface [polypeptide binding]; other site
745310009641	non-prolyl cis peptide bond; other site
745310009642	insertion regions; other site
745310009643	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009644	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310009645	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009646	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009647	N-terminal plug; other site
745310009648	ligand-binding site [chemical binding]; other site
745310009649	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
745310009650	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
745310009651	putative metal binding site [ion binding]; other site
745310009652	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310009653	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310009654	[2Fe-2S] cluster binding site [ion binding]; other site
745310009655	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
745310009656	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310009657	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
745310009658	acyl-activating enzyme (AAE) consensus motif; other site
745310009659	acyl-activating enzyme (AAE) consensus motif; other site
745310009660	putative AMP binding site [chemical binding]; other site
745310009661	putative active site [active]
745310009662	putative CoA binding site [chemical binding]; other site
745310009663	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310009664	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310009665	active site
745310009666	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310009667	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
745310009668	active site
745310009669	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310009670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310009671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009672	Cupin; Region: Cupin_6; pfam12852
745310009673	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
745310009674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310009675	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
745310009676	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
745310009677	ligand binding site [chemical binding]; other site
745310009678	flexible hinge region; other site
745310009679	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
745310009680	non-specific DNA interactions [nucleotide binding]; other site
745310009681	DNA binding site [nucleotide binding]
745310009682	sequence specific DNA binding site [nucleotide binding]; other site
745310009683	putative cAMP binding site [chemical binding]; other site
745310009684	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
745310009685	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
745310009686	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009687	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009688	N-terminal plug; other site
745310009689	ligand-binding site [chemical binding]; other site
745310009690	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
745310009691	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
745310009692	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
745310009693	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
745310009694	acyl-activating enzyme (AAE) consensus motif; other site
745310009695	putative AMP binding site [chemical binding]; other site
745310009696	putative active site [active]
745310009697	putative CoA binding site [chemical binding]; other site
745310009698	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310009699	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310009700	active site
745310009701	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
745310009702	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
745310009703	DUF35 OB-fold domain; Region: DUF35; pfam01796
745310009704	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310009705	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
745310009706	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
745310009707	active site
745310009708	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
745310009709	putative active site [active]
745310009710	putative catalytic site [active]
745310009711	lipid-transfer protein; Provisional; Region: PRK07855
745310009712	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
745310009713	active site
745310009714	methionine sulfoxide reductase B; Provisional; Region: PRK00222
745310009715	SelR domain; Region: SelR; pfam01641
745310009716	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
745310009717	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009718	N-terminal plug; other site
745310009719	ligand-binding site [chemical binding]; other site
745310009720	Transcriptional regulators [Transcription]; Region: FadR; COG2186
745310009721	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
745310009722	DNA-binding site [nucleotide binding]; DNA binding site
745310009723	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
745310009724	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
745310009725	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
745310009726	metal binding site [ion binding]; metal-binding site
745310009727	substrate binding pocket [chemical binding]; other site
745310009728	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009729	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009730	N-terminal plug; other site
745310009731	ligand-binding site [chemical binding]; other site
745310009732	MarR family; Region: MarR; pfam01047
745310009733	Fusaric acid resistance protein family; Region: FUSC; pfam04632
745310009734	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
745310009735	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
745310009736	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310009737	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310009738	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310009739	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
745310009740	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
745310009741	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
745310009742	putative active site [active]
745310009743	putative PHP Thumb interface [polypeptide binding]; other site
745310009744	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
745310009745	generic binding surface II; other site
745310009746	generic binding surface I; other site
745310009747	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
745310009748	active site
745310009749	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
745310009750	hydroxyglutarate oxidase; Provisional; Region: PRK11728
745310009751	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
745310009752	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
745310009753	active site
745310009754	Fe-S cluster binding site [ion binding]; other site
745310009755	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310009756	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310009757	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310009758	catalytic residue [active]
745310009759	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
745310009760	MPT binding site; other site
745310009761	trimer interface [polypeptide binding]; other site
745310009762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310009763	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310009764	putative substrate translocation pore; other site
745310009765	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
745310009766	Sulfatase; Region: Sulfatase; pfam00884
745310009767	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
745310009768	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
745310009769	active site
745310009770	iron coordination sites [ion binding]; other site
745310009771	substrate binding pocket [chemical binding]; other site
745310009772	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
745310009773	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
745310009774	active site
745310009775	iron coordination sites [ion binding]; other site
745310009776	substrate binding pocket [chemical binding]; other site
745310009777	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
745310009778	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
745310009779	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009780	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009781	N-terminal plug; other site
745310009782	ligand-binding site [chemical binding]; other site
745310009783	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529
745310009784	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
745310009785	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
745310009786	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
745310009787	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
745310009788	threonine dehydratase; Provisional; Region: PRK07334
745310009789	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
745310009790	tetramer interface [polypeptide binding]; other site
745310009791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
745310009792	catalytic residue [active]
745310009793	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
745310009794	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
745310009795	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
745310009796	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310009797	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
745310009798	Amidohydrolase family; Region: Amidohydro_3; pfam07969
745310009799	active site
745310009800	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
745310009801	Uncharacterized conserved protein [Function unknown]; Region: COG5361
745310009802	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
745310009803	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
745310009804	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
745310009805	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
745310009806	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
745310009807	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
745310009808	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
745310009809	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
745310009810	XdhC Rossmann domain; Region: XdhC_C; pfam13478
745310009811	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
745310009812	MPT binding site; other site
745310009813	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
745310009814	metal-binding site
745310009815	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
745310009816	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
745310009817	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310009818	pantothenate kinase; Provisional; Region: PRK05439
745310009819	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
745310009820	ATP-binding site [chemical binding]; other site
745310009821	CoA-binding site [chemical binding]; other site
745310009822	Mg2+-binding site [ion binding]; other site
745310009823	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310009824	classical (c) SDRs; Region: SDR_c; cd05233
745310009825	NAD(P) binding site [chemical binding]; other site
745310009826	active site
745310009827	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310009828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310009829	NAD(P) binding site [chemical binding]; other site
745310009830	active site
745310009831	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
745310009832	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
745310009833	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
745310009834	catalytic residue [active]
745310009835	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
745310009836	Permease; Region: Permease; pfam02405
745310009837	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
745310009838	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
745310009839	Walker A/P-loop; other site
745310009840	ATP binding site [chemical binding]; other site
745310009841	Q-loop/lid; other site
745310009842	ABC transporter signature motif; other site
745310009843	Walker B; other site
745310009844	D-loop; other site
745310009845	H-loop/switch region; other site
745310009846	putative acyltransferase; Provisional; Region: PRK05790
745310009847	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310009848	dimer interface [polypeptide binding]; other site
745310009849	active site
745310009850	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
745310009851	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
745310009852	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
745310009853	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
745310009854	Predicted methyltransferase [General function prediction only]; Region: COG4798
745310009855	Methyltransferase domain; Region: Methyltransf_23; pfam13489
745310009856	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
745310009857	Uncharacterized conserved protein [Function unknown]; Region: COG0062
745310009858	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
745310009859	putative substrate binding site [chemical binding]; other site
745310009860	putative ATP binding site [chemical binding]; other site
745310009861	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
745310009862	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
745310009863	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310009864	Walker A motif; other site
745310009865	ATP binding site [chemical binding]; other site
745310009866	Walker B motif; other site
745310009867	arginine finger; other site
745310009868	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
745310009869	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
745310009870	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
745310009871	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310009872	Walker A/P-loop; other site
745310009873	ATP binding site [chemical binding]; other site
745310009874	Q-loop/lid; other site
745310009875	ABC transporter signature motif; other site
745310009876	Walker B; other site
745310009877	D-loop; other site
745310009878	H-loop/switch region; other site
745310009879	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
745310009880	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
745310009881	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
745310009882	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
745310009883	active site
745310009884	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310009885	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
745310009886	putative C-terminal domain interface [polypeptide binding]; other site
745310009887	putative GSH binding site (G-site) [chemical binding]; other site
745310009888	putative dimer interface [polypeptide binding]; other site
745310009889	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
745310009890	putative N-terminal domain interface [polypeptide binding]; other site
745310009891	putative dimer interface [polypeptide binding]; other site
745310009892	putative substrate binding pocket (H-site) [chemical binding]; other site
745310009893	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
745310009894	heterotetramer interface [polypeptide binding]; other site
745310009895	active site pocket [active]
745310009896	cleavage site
745310009897	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
745310009898	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
745310009899	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
745310009900	SEC-C motif; Region: SEC-C; pfam02810
745310009901	PilZ domain; Region: PilZ; pfam07238
745310009902	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
745310009903	GIY-YIG motif/motif A; other site
745310009904	putative active site [active]
745310009905	putative metal binding site [ion binding]; other site
745310009906	S-formylglutathione hydrolase; Region: PLN02442
745310009907	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
745310009908	Cytochrome P450; Region: p450; cl12078
745310009909	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
745310009910	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
745310009911	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
745310009912	NAD(P) binding site [chemical binding]; other site
745310009913	catalytic residues [active]
745310009914	hypothetical protein; Provisional; Region: PRK06194
745310009915	classical (c) SDRs; Region: SDR_c; cd05233
745310009916	NAD(P) binding site [chemical binding]; other site
745310009917	active site
745310009918	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009919	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310009920	classical (c) SDRs; Region: SDR_c; cd05233
745310009921	NAD(P) binding site [chemical binding]; other site
745310009922	active site
745310009923	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
745310009924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310009925	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310009926	putative substrate translocation pore; other site
745310009927	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310009928	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
745310009929	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009930	N-terminal plug; other site
745310009931	ligand-binding site [chemical binding]; other site
745310009932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310009933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310009934	WHG domain; Region: WHG; pfam13305
745310009935	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
745310009936	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
745310009937	Trp docking motif [polypeptide binding]; other site
745310009938	putative active site [active]
745310009939	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
745310009940	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310009941	TPR motif; other site
745310009942	binding surface
745310009943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
745310009944	TPR motif; other site
745310009945	Tetratricopeptide repeat; Region: TPR_12; pfam13424
745310009946	binding surface
745310009947	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
745310009948	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
745310009949	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
745310009950	enoyl-CoA hydratase; Provisional; Region: PRK06127
745310009951	substrate binding site [chemical binding]; other site
745310009952	oxyanion hole (OAH) forming residues; other site
745310009953	trimer interface [polypeptide binding]; other site
745310009954	N-formylglutamate amidohydrolase; Region: FGase; cl01522
745310009955	EVE domain; Region: EVE; pfam01878
745310009956	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310009957	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310009958	N-terminal plug; other site
745310009959	ligand-binding site [chemical binding]; other site
745310009960	SnoaL-like domain; Region: SnoaL_2; pfam12680
745310009961	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
745310009962	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310009963	active site
745310009964	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310009965	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
745310009966	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
745310009967	active site
745310009968	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
745310009969	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
745310009970	G1 box; other site
745310009971	putative GEF interaction site [polypeptide binding]; other site
745310009972	GTP/Mg2+ binding site [chemical binding]; other site
745310009973	Switch I region; other site
745310009974	G2 box; other site
745310009975	G3 box; other site
745310009976	Switch II region; other site
745310009977	G4 box; other site
745310009978	G5 box; other site
745310009979	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
745310009980	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
745310009981	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
745310009982	BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463
745310009983	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
745310009984	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
745310009985	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
745310009986	DsbD alpha interface [polypeptide binding]; other site
745310009987	catalytic residues [active]
745310009988	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
745310009989	putative catalytic residue [active]
745310009990	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310009991	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310009992	Amidohydrolase; Region: Amidohydro_4; pfam13147
745310009993	active site
745310009994	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
745310009995	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310009996	metal binding site [ion binding]; metal-binding site
745310009997	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
745310009998	FtsH Extracellular; Region: FtsH_ext; pfam06480
745310009999	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
745310010000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310010001	Walker A motif; other site
745310010002	ATP binding site [chemical binding]; other site
745310010003	Walker B motif; other site
745310010004	arginine finger; other site
745310010005	Peptidase family M41; Region: Peptidase_M41; pfam01434
745310010006	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
745310010007	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
745310010008	Ligand Binding Site [chemical binding]; other site
745310010009	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
745310010010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
745310010011	binding surface
745310010012	TPR motif; other site
745310010013	Helix-turn-helix domain; Region: HTH_25; pfam13413
745310010014	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
745310010015	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
745310010016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
745310010017	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
745310010018	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
745310010019	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
745310010020	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
745310010021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310010022	ATP binding site [chemical binding]; other site
745310010023	Mg2+ binding site [ion binding]; other site
745310010024	G-X-G motif; other site
745310010025	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310010026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010027	active site
745310010028	phosphorylation site [posttranslational modification]
745310010029	intermolecular recognition site; other site
745310010030	dimerization interface [polypeptide binding]; other site
745310010031	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310010032	DNA binding site [nucleotide binding]
745310010033	hypothetical protein; Provisional; Region: PRK13687
745310010034	Predicted acetyltransferase [General function prediction only]; Region: COG3153
745310010035	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310010036	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
745310010037	NAD(P) binding site [chemical binding]; other site
745310010038	active site
745310010039	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310010040	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
745310010041	NAD(P) binding site [chemical binding]; other site
745310010042	active site
745310010043	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
745310010044	classical (c) SDRs; Region: SDR_c; cd05233
745310010045	NAD(P) binding site [chemical binding]; other site
745310010046	active site
745310010047	Predicted transcriptional regulators [Transcription]; Region: COG1733
745310010048	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
745310010049	short chain dehydrogenase; Provisional; Region: PRK06197
745310010050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310010051	NAD(P) binding site [chemical binding]; other site
745310010052	active site
745310010053	AMP nucleosidase; Provisional; Region: PRK08292
745310010054	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
745310010055	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
745310010056	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
745310010057	catalytic triad [active]
745310010058	dimer interface [polypeptide binding]; other site
745310010059	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
745310010060	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
745310010061	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
745310010062	homotetramer interface [polypeptide binding]; other site
745310010063	ligand binding site [chemical binding]; other site
745310010064	catalytic site [active]
745310010065	NAD binding site [chemical binding]; other site
745310010066	Predicted membrane protein [Function unknown]; Region: COG2860
745310010067	UPF0126 domain; Region: UPF0126; pfam03458
745310010068	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
745310010069	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
745310010070	tandem repeat interface [polypeptide binding]; other site
745310010071	oligomer interface [polypeptide binding]; other site
745310010072	active site residues [active]
745310010073	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
745310010074	tandem repeat interface [polypeptide binding]; other site
745310010075	oligomer interface [polypeptide binding]; other site
745310010076	active site residues [active]
745310010077	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
745310010078	oligomerisation interface [polypeptide binding]; other site
745310010079	mobile loop; other site
745310010080	roof hairpin; other site
745310010081	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
745310010082	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
745310010083	ring oligomerisation interface [polypeptide binding]; other site
745310010084	ATP/Mg binding site [chemical binding]; other site
745310010085	stacking interactions; other site
745310010086	hinge regions; other site
745310010087	VacJ like lipoprotein; Region: VacJ; cl01073
745310010088	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310010089	dimerization interface [polypeptide binding]; other site
745310010090	putative DNA binding site [nucleotide binding]; other site
745310010091	putative Zn2+ binding site [ion binding]; other site
745310010092	Methyltransferase domain; Region: Methyltransf_23; pfam13489
745310010093	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310010094	S-adenosylmethionine binding site [chemical binding]; other site
745310010095	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
745310010096	FAD binding site [chemical binding]; other site
745310010097	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
745310010098	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
745310010099	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
745310010100	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
745310010101	substrate binding pocket [chemical binding]; other site
745310010102	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
745310010103	B12 binding site [chemical binding]; other site
745310010104	cobalt ligand [ion binding]; other site
745310010105	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
745310010106	camphor resistance protein CrcB; Provisional; Region: PRK14195
745310010107	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
745310010108	putative lipid kinase; Reviewed; Region: PRK13057
745310010109	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
745310010110	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
745310010111	NADP binding site [chemical binding]; other site
745310010112	active site
745310010113	steroid binding site; other site
745310010114	short chain dehydrogenase; Provisional; Region: PRK12937
745310010115	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
745310010116	NADP binding site [chemical binding]; other site
745310010117	homodimer interface [polypeptide binding]; other site
745310010118	active site
745310010119	substrate binding site [chemical binding]; other site
745310010120	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310010121	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310010122	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
745310010123	putative effector binding pocket; other site
745310010124	putative dimerization interface [polypeptide binding]; other site
745310010125	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
745310010126	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010127	putative substrate translocation pore; other site
745310010128	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
745310010129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010130	putative substrate translocation pore; other site
745310010131	Transcriptional regulators [Transcription]; Region: PurR; COG1609
745310010132	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
745310010133	DNA binding site [nucleotide binding]
745310010134	domain linker motif; other site
745310010135	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
745310010136	putative ligand binding site [chemical binding]; other site
745310010137	putative dimerization interface [polypeptide binding]; other site
745310010138	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310010139	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310010140	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
745310010141	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
745310010142	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
745310010143	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
745310010144	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
745310010145	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
745310010146	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010147	putative substrate translocation pore; other site
745310010148	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
745310010149	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
745310010150	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
745310010151	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
745310010152	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
745310010153	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
745310010154	phosphogluconate dehydratase; Validated; Region: PRK09054
745310010155	6-phosphogluconate dehydratase; Region: edd; TIGR01196
745310010156	Glucokinase; Region: Glucokinase; pfam02685
745310010157	glucokinase, proteobacterial type; Region: glk; TIGR00749
745310010158	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310010159	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310010160	N-terminal plug; other site
745310010161	ligand-binding site [chemical binding]; other site
745310010162	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310010163	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
745310010164	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
745310010165	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
745310010166	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
745310010167	Phosphotransferase enzyme family; Region: APH; pfam01636
745310010168	putative active site [active]
745310010169	putative substrate binding site [chemical binding]; other site
745310010170	ATP binding site [chemical binding]; other site
745310010171	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310010172	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310010173	active site
745310010174	catalytic tetrad [active]
745310010175	Protein of unknown function, DUF481; Region: DUF481; pfam04338
745310010176	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
745310010177	putative active site [active]
745310010178	Ap4A binding site [chemical binding]; other site
745310010179	nudix motif; other site
745310010180	putative metal binding site [ion binding]; other site
745310010181	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
745310010182	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
745310010183	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
745310010184	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
745310010185	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
745310010186	dimer interface [polypeptide binding]; other site
745310010187	PYR/PP interface [polypeptide binding]; other site
745310010188	TPP binding site [chemical binding]; other site
745310010189	substrate binding site [chemical binding]; other site
745310010190	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
745310010191	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
745310010192	TPP-binding site [chemical binding]; other site
745310010193	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
745310010194	Isochorismatase family; Region: Isochorismatase; pfam00857
745310010195	catalytic triad [active]
745310010196	dimer interface [polypeptide binding]; other site
745310010197	conserved cis-peptide bond; other site
745310010198	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
745310010199	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
745310010200	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
745310010201	active site
745310010202	Predicted membrane protein [Function unknown]; Region: COG2259
745310010203	Transmembrane secretion effector; Region: MFS_3; pfam05977
745310010204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010205	putative substrate translocation pore; other site
745310010206	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
745310010207	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
745310010208	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
745310010209	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310010210	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310010211	Amidohydrolase; Region: Amidohydro_4; pfam13147
745310010212	active site
745310010213	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
745310010214	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
745310010215	Uncharacterized conserved protein [Function unknown]; Region: COG1742
745310010216	hypothetical protein; Provisional; Region: PRK06132
745310010217	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
745310010218	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310010219	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
745310010220	active site
745310010221	FMN binding site [chemical binding]; other site
745310010222	substrate binding site [chemical binding]; other site
745310010223	homotetramer interface [polypeptide binding]; other site
745310010224	catalytic residue [active]
745310010225	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
745310010226	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
745310010227	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
745310010228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310010229	Walker A/P-loop; other site
745310010230	ATP binding site [chemical binding]; other site
745310010231	Q-loop/lid; other site
745310010232	ABC transporter signature motif; other site
745310010233	Walker B; other site
745310010234	D-loop; other site
745310010235	H-loop/switch region; other site
745310010236	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
745310010237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
745310010238	dimer interface [polypeptide binding]; other site
745310010239	conserved gate region; other site
745310010240	putative PBP binding loops; other site
745310010241	ABC-ATPase subunit interface; other site
745310010242	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
745310010243	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
745310010244	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
745310010245	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
745310010246	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
745310010247	active site
745310010248	DNA polymerase IV; Validated; Region: PRK02406
745310010249	DNA binding site [nucleotide binding]
745310010250	Protein of unknown function (DUF805); Region: DUF805; pfam05656
745310010251	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
745310010252	dimer interface [polypeptide binding]; other site
745310010253	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
745310010254	putative radical transfer pathway; other site
745310010255	diiron center [ion binding]; other site
745310010256	tyrosyl radical; other site
745310010257	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
745310010258	cofactor binding site; other site
745310010259	metal binding site [ion binding]; metal-binding site
745310010260	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310010261	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
745310010262	putative C-terminal domain interface [polypeptide binding]; other site
745310010263	putative GSH binding site (G-site) [chemical binding]; other site
745310010264	putative dimer interface [polypeptide binding]; other site
745310010265	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310010266	N-terminal domain interface [polypeptide binding]; other site
745310010267	dimer interface [polypeptide binding]; other site
745310010268	substrate binding pocket (H-site) [chemical binding]; other site
745310010269	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
745310010270	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
745310010271	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
745310010272	nucleotide binding pocket [chemical binding]; other site
745310010273	K-X-D-G motif; other site
745310010274	catalytic site [active]
745310010275	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
745310010276	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
745310010277	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
745310010278	Dimer interface [polypeptide binding]; other site
745310010279	BRCT sequence motif; other site
745310010280	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
745310010281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010282	active site
745310010283	phosphorylation site [posttranslational modification]
745310010284	intermolecular recognition site; other site
745310010285	dimerization interface [polypeptide binding]; other site
745310010286	LytTr DNA-binding domain; Region: LytTR; smart00850
745310010287	Histidine kinase; Region: His_kinase; pfam06580
745310010288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310010289	ATP binding site [chemical binding]; other site
745310010290	Mg2+ binding site [ion binding]; other site
745310010291	G-X-G motif; other site
745310010292	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
745310010293	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
745310010294	DEAD-like helicases superfamily; Region: DEXDc; smart00487
745310010295	ATP binding site [chemical binding]; other site
745310010296	Mg++ binding site [ion binding]; other site
745310010297	motif III; other site
745310010298	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
745310010299	nucleotide binding region [chemical binding]; other site
745310010300	ATP-binding site [chemical binding]; other site
745310010301	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
745310010302	FAD binding domain; Region: FAD_binding_4; pfam01565
745310010303	SapC; Region: SapC; pfam07277
745310010304	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
745310010305	Response regulator receiver domain; Region: Response_reg; pfam00072
745310010306	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010307	active site
745310010308	phosphorylation site [posttranslational modification]
745310010309	intermolecular recognition site; other site
745310010310	dimerization interface [polypeptide binding]; other site
745310010311	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310010312	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
745310010313	putative NAD(P) binding site [chemical binding]; other site
745310010314	Helix-turn-helix domain; Region: HTH_31; pfam13560
745310010315	sequence-specific DNA binding site [nucleotide binding]; other site
745310010316	salt bridge; other site
745310010317	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
745310010318	hydroperoxidase II; Provisional; Region: katE; PRK11249
745310010319	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
745310010320	heme binding pocket [chemical binding]; other site
745310010321	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
745310010322	domain interactions; other site
745310010323	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
745310010324	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
745310010325	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
745310010326	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
745310010327	classical (c) SDRs; Region: SDR_c; cd05233
745310010328	NAD(P) binding site [chemical binding]; other site
745310010329	active site
745310010330	PAS domain S-box; Region: sensory_box; TIGR00229
745310010331	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310010332	putative active site [active]
745310010333	heme pocket [chemical binding]; other site
745310010334	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
745310010335	HWE histidine kinase; Region: HWE_HK; smart00911
745310010336	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
745310010337	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
745310010338	NAD binding site [chemical binding]; other site
745310010339	catalytic residues [active]
745310010340	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010341	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310010342	putative substrate translocation pore; other site
745310010343	hypothetical protein; Provisional; Region: PRK06194
745310010344	classical (c) SDRs; Region: SDR_c; cd05233
745310010345	NAD(P) binding site [chemical binding]; other site
745310010346	active site
745310010347	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
745310010348	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
745310010349	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
745310010350	[2Fe-2S] cluster binding site [ion binding]; other site
745310010351	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310010352	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310010353	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
745310010354	putative effector binding pocket; other site
745310010355	dimerization interface [polypeptide binding]; other site
745310010356	Amidohydrolase; Region: Amidohydro_2; pfam04909
745310010357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010358	Major Facilitator Superfamily; Region: MFS_1; pfam07690
745310010359	putative substrate translocation pore; other site
745310010360	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310010361	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310010362	N-terminal plug; other site
745310010363	ligand-binding site [chemical binding]; other site
745310010364	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310010365	non-specific DNA binding site [nucleotide binding]; other site
745310010366	salt bridge; other site
745310010367	sequence-specific DNA binding site [nucleotide binding]; other site
745310010368	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
745310010369	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
745310010370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310010371	Coenzyme A binding pocket [chemical binding]; other site
745310010372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
745310010373	Transmembrane secretion effector; Region: MFS_3; pfam05977
745310010374	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310010375	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
745310010376	C-terminal domain interface [polypeptide binding]; other site
745310010377	GSH binding site (G-site) [chemical binding]; other site
745310010378	dimer interface [polypeptide binding]; other site
745310010379	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
745310010380	N-terminal domain interface [polypeptide binding]; other site
745310010381	dimer interface [polypeptide binding]; other site
745310010382	substrate binding pocket (H-site) [chemical binding]; other site
745310010383	Uncharacterized conserved protein [Function unknown]; Region: COG5323
745310010384	Phage portal protein; Region: Phage_portal; pfam04860
745310010385	Phage-related protein [Function unknown]; Region: COG4695
745310010386	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
745310010387	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
745310010388	Phage capsid family; Region: Phage_capsid; pfam05065
745310010389	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
745310010390	active site
745310010391	catalytic triad [active]
745310010392	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
745310010393	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
745310010394	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
745310010395	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
745310010396	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
745310010397	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
745310010398	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
745310010399	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
745310010400	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
745310010401	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
745310010402	Putative phage tail protein; Region: Phage-tail_3; pfam13550
745310010403	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
745310010404	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
745310010405	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
745310010406	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
745310010407	ligand binding site [chemical binding]; other site
745310010408	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
745310010409	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
745310010410	G1 box; other site
745310010411	putative GEF interaction site [polypeptide binding]; other site
745310010412	GTP/Mg2+ binding site [chemical binding]; other site
745310010413	Switch I region; other site
745310010414	G2 box; other site
745310010415	G3 box; other site
745310010416	Switch II region; other site
745310010417	G4 box; other site
745310010418	G5 box; other site
745310010419	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
745310010420	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
745310010421	glycerol kinase; Provisional; Region: glpK; PRK00047
745310010422	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
745310010423	N- and C-terminal domain interface [polypeptide binding]; other site
745310010424	active site
745310010425	MgATP binding site [chemical binding]; other site
745310010426	catalytic site [active]
745310010427	metal binding site [ion binding]; metal-binding site
745310010428	glycerol binding site [chemical binding]; other site
745310010429	homotetramer interface [polypeptide binding]; other site
745310010430	homodimer interface [polypeptide binding]; other site
745310010431	FBP binding site [chemical binding]; other site
745310010432	protein IIAGlc interface [polypeptide binding]; other site
745310010433	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
745310010434	putative active site [active]
745310010435	ABC transporter ATPase component; Reviewed; Region: PRK11147
745310010436	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310010437	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310010438	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
745310010439	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
745310010440	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310010441	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
745310010442	Soluble P-type ATPase [General function prediction only]; Region: COG4087
745310010443	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
745310010444	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310010445	Ligand Binding Site [chemical binding]; other site
745310010446	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310010447	Ligand Binding Site [chemical binding]; other site
745310010448	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
745310010449	Ligand Binding Site [chemical binding]; other site
745310010450	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
745310010451	active site
745310010452	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
745310010453	substrate binding site [chemical binding]; other site
745310010454	dimerization interface [polypeptide binding]; other site
745310010455	active site
745310010456	calcium binding site [ion binding]; other site
745310010457	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
745310010458	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
745310010459	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
745310010460	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
745310010461	Walker A/P-loop; other site
745310010462	ATP binding site [chemical binding]; other site
745310010463	Q-loop/lid; other site
745310010464	ABC transporter signature motif; other site
745310010465	Walker B; other site
745310010466	D-loop; other site
745310010467	H-loop/switch region; other site
745310010468	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
745310010469	Walker A/P-loop; other site
745310010470	ATP binding site [chemical binding]; other site
745310010471	Q-loop/lid; other site
745310010472	ABC transporter signature motif; other site
745310010473	Walker B; other site
745310010474	D-loop; other site
745310010475	H-loop/switch region; other site
745310010476	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
745310010477	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
745310010478	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310010479	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310010480	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
745310010481	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
745310010482	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
745310010483	homodimer interface [polypeptide binding]; other site
745310010484	substrate-cofactor binding pocket; other site
745310010485	catalytic residue [active]
745310010486	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310010487	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310010488	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
745310010489	dimerization interface [polypeptide binding]; other site
745310010490	substrate binding pocket [chemical binding]; other site
745310010491	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310010492	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310010493	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310010494	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310010495	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
745310010496	Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043
745310010497	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
745310010498	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310010499	dimerization interface [polypeptide binding]; other site
745310010500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310010501	dimer interface [polypeptide binding]; other site
745310010502	phosphorylation site [posttranslational modification]
745310010503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310010504	ATP binding site [chemical binding]; other site
745310010505	Mg2+ binding site [ion binding]; other site
745310010506	G-X-G motif; other site
745310010507	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
745310010508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010509	active site
745310010510	phosphorylation site [posttranslational modification]
745310010511	intermolecular recognition site; other site
745310010512	dimerization interface [polypeptide binding]; other site
745310010513	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
745310010514	DNA binding site [nucleotide binding]
745310010515	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
745310010516	protein binding site [polypeptide binding]; other site
745310010517	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
745310010518	homodimer interface [polypeptide binding]; other site
745310010519	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310010520	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
745310010521	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310010522	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
745310010523	NAD(P) binding site [chemical binding]; other site
745310010524	active site
745310010525	gamma-glutamyl kinase; Provisional; Region: PRK05429
745310010526	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
745310010527	nucleotide binding site [chemical binding]; other site
745310010528	homotetrameric interface [polypeptide binding]; other site
745310010529	putative phosphate binding site [ion binding]; other site
745310010530	putative allosteric binding site; other site
745310010531	PUA domain; Region: PUA; pfam01472
745310010532	GTPase CgtA; Reviewed; Region: obgE; PRK12299
745310010533	GTP1/OBG; Region: GTP1_OBG; pfam01018
745310010534	Obg GTPase; Region: Obg; cd01898
745310010535	G1 box; other site
745310010536	GTP/Mg2+ binding site [chemical binding]; other site
745310010537	Switch I region; other site
745310010538	G2 box; other site
745310010539	G3 box; other site
745310010540	Switch II region; other site
745310010541	G4 box; other site
745310010542	G5 box; other site
745310010543	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
745310010544	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
745310010545	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
745310010546	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
745310010547	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
745310010548	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
745310010549	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
745310010550	Beta-lactamase; Region: Beta-lactamase; pfam00144
745310010551	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
745310010552	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
745310010553	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
745310010554	substrate binding site [chemical binding]; other site
745310010555	ligand binding site [chemical binding]; other site
745310010556	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
745310010557	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
745310010558	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
745310010559	substrate binding site [chemical binding]; other site
745310010560	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310010561	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
745310010562	NAD(P) binding site [chemical binding]; other site
745310010563	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
745310010564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310010565	short chain dehydrogenase; Provisional; Region: PRK06924
745310010566	NAD(P) binding site [chemical binding]; other site
745310010567	active site
745310010568	amidophosphoribosyltransferase; Provisional; Region: PRK09123
745310010569	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
745310010570	active site
745310010571	tetramer interface [polypeptide binding]; other site
745310010572	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
745310010573	active site
745310010574	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
745310010575	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
745310010576	ligand binding site [chemical binding]; other site
745310010577	active site
745310010578	UGI interface [polypeptide binding]; other site
745310010579	catalytic site [active]
745310010580	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
745310010581	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
745310010582	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
745310010583	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
745310010584	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
745310010585	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
745310010586	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
745310010587	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
745310010588	lipoyl-biotinyl attachment site [posttranslational modification]; other site
745310010589	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
745310010590	DNA binding site [nucleotide binding]
745310010591	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
745310010592	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
745310010593	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
745310010594	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
745310010595	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
745310010596	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
745310010597	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
745310010598	RPB1 interaction site [polypeptide binding]; other site
745310010599	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
745310010600	trimer interface [polypeptide binding]; other site
745310010601	active site
745310010602	substrate binding site [chemical binding]; other site
745310010603	CoA binding site [chemical binding]; other site
745310010604	2-isopropylmalate synthase; Validated; Region: PRK00915
745310010605	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
745310010606	active site
745310010607	catalytic residues [active]
745310010608	metal binding site [ion binding]; metal-binding site
745310010609	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
745310010610	FAD binding domain; Region: FAD_binding_3; pfam01494
745310010611	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
745310010612	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
745310010613	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
745310010614	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
745310010615	Predicted flavoprotein [General function prediction only]; Region: COG0431
745310010616	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
745310010617	ribonuclease R; Region: RNase_R; TIGR02063
745310010618	RNB domain; Region: RNB; pfam00773
745310010619	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
745310010620	RNA binding site [nucleotide binding]; other site
745310010621	Uncharacterized conserved protein [Function unknown]; Region: COG5361
745310010622	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
745310010623	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
745310010624	trigger factor; Provisional; Region: tig; PRK01490
745310010625	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
745310010626	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
745310010627	Acyltransferase family; Region: Acyl_transf_3; pfam01757
745310010628	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
745310010629	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
745310010630	Ligand binding site; other site
745310010631	Putative Catalytic site; other site
745310010632	DXD motif; other site
745310010633	Clp protease; Region: CLP_protease; pfam00574
745310010634	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
745310010635	oligomer interface [polypeptide binding]; other site
745310010636	active site residues [active]
745310010637	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
745310010638	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
745310010639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310010640	Walker A motif; other site
745310010641	ATP binding site [chemical binding]; other site
745310010642	Walker B motif; other site
745310010643	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
745310010644	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
745310010645	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
745310010646	NlpC/P60 family; Region: NLPC_P60; cl17555
745310010647	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
745310010648	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
745310010649	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
745310010650	interface (dimer of trimers) [polypeptide binding]; other site
745310010651	Substrate-binding/catalytic site; other site
745310010652	Zn-binding sites [ion binding]; other site
745310010653	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
745310010654	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
745310010655	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
745310010656	FeS/SAM binding site; other site
745310010657	Ion channel; Region: Ion_trans_2; pfam07885
745310010658	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
745310010659	TrkA-N domain; Region: TrkA_N; pfam02254
745310010660	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
745310010661	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
745310010662	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
745310010663	Peptidase family M23; Region: Peptidase_M23; pfam01551
745310010664	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
745310010665	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
745310010666	seryl-tRNA synthetase; Provisional; Region: PRK05431
745310010667	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
745310010668	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
745310010669	dimer interface [polypeptide binding]; other site
745310010670	active site
745310010671	motif 1; other site
745310010672	motif 2; other site
745310010673	motif 3; other site
745310010674	Protein required for attachment to host cells; Region: Host_attach; pfam10116
745310010675	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
745310010676	PilZ domain; Region: PilZ; pfam07238
745310010677	Protein of unknown function (DUF465); Region: DUF465; cl01070
745310010678	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
745310010679	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
745310010680	putative dimer interface [polypeptide binding]; other site
745310010681	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
745310010682	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
745310010683	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310010684	FMN binding site [chemical binding]; other site
745310010685	substrate binding site [chemical binding]; other site
745310010686	putative catalytic residue [active]
745310010687	aspartate kinase; Reviewed; Region: PRK06635
745310010688	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
745310010689	putative nucleotide binding site [chemical binding]; other site
745310010690	putative catalytic residues [active]
745310010691	putative Mg ion binding site [ion binding]; other site
745310010692	putative aspartate binding site [chemical binding]; other site
745310010693	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
745310010694	putative allosteric regulatory site; other site
745310010695	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
745310010696	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
745310010697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310010698	S-adenosylmethionine binding site [chemical binding]; other site
745310010699	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
745310010700	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
745310010701	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
745310010702	C-terminal domain interface [polypeptide binding]; other site
745310010703	GSH binding site (G-site) [chemical binding]; other site
745310010704	dimer interface [polypeptide binding]; other site
745310010705	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
745310010706	N-terminal domain interface [polypeptide binding]; other site
745310010707	dimer interface [polypeptide binding]; other site
745310010708	substrate binding pocket (H-site) [chemical binding]; other site
745310010709	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310010710	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310010711	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
745310010712	L-aspartate oxidase; Provisional; Region: PRK06175
745310010713	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
745310010714	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
745310010715	FMN binding site [chemical binding]; other site
745310010716	substrate binding site [chemical binding]; other site
745310010717	putative catalytic residue [active]
745310010718	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
745310010719	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
745310010720	C-terminal domain interface [polypeptide binding]; other site
745310010721	GSH binding site (G-site) [chemical binding]; other site
745310010722	dimer interface [polypeptide binding]; other site
745310010723	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
745310010724	N-terminal domain interface [polypeptide binding]; other site
745310010725	putative dimer interface [polypeptide binding]; other site
745310010726	active site
745310010727	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
745310010728	YceI-like domain; Region: YceI; smart00867
745310010729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310010730	PAS domain; Region: PAS_9; pfam13426
745310010731	putative active site [active]
745310010732	heme pocket [chemical binding]; other site
745310010733	PAS fold; Region: PAS_3; pfam08447
745310010734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310010735	heme pocket [chemical binding]; other site
745310010736	putative active site [active]
745310010737	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310010738	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310010739	metal binding site [ion binding]; metal-binding site
745310010740	active site
745310010741	I-site; other site
745310010742	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
745310010743	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
745310010744	acyl-activating enzyme (AAE) consensus motif; other site
745310010745	AMP binding site [chemical binding]; other site
745310010746	active site
745310010747	CoA binding site [chemical binding]; other site
745310010748	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
745310010749	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
745310010750	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
745310010751	Glutamate binding site [chemical binding]; other site
745310010752	NAD binding site [chemical binding]; other site
745310010753	catalytic residues [active]
745310010754	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310010755	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310010756	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310010757	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310010758	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310010759	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
745310010760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010761	active site
745310010762	phosphorylation site [posttranslational modification]
745310010763	intermolecular recognition site; other site
745310010764	dimerization interface [polypeptide binding]; other site
745310010765	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310010766	DNA binding residues [nucleotide binding]
745310010767	dimerization interface [polypeptide binding]; other site
745310010768	Response regulator receiver domain; Region: Response_reg; pfam00072
745310010769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310010770	active site
745310010771	phosphorylation site [posttranslational modification]
745310010772	intermolecular recognition site; other site
745310010773	dimerization interface [polypeptide binding]; other site
745310010774	SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829
745310010775	active site
745310010776	catalytic triad [active]
745310010777	oxyanion hole [active]
745310010778	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
745310010779	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
745310010780	oxyanion hole [active]
745310010781	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
745310010782	catalytic triad [active]
745310010783	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
745310010784	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
745310010785	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
745310010786	GDP-binding site [chemical binding]; other site
745310010787	ACT binding site; other site
745310010788	IMP binding site; other site
745310010789	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
745310010790	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
745310010791	motif 1; other site
745310010792	dimer interface [polypeptide binding]; other site
745310010793	active site
745310010794	motif 2; other site
745310010795	motif 3; other site
745310010796	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
745310010797	putative active site [active]
745310010798	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
745310010799	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
745310010800	ligand binding site [chemical binding]; other site
745310010801	NAD binding site [chemical binding]; other site
745310010802	dimerization interface [polypeptide binding]; other site
745310010803	catalytic site [active]
745310010804	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
745310010805	putative L-serine binding site [chemical binding]; other site
745310010806	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
745310010807	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
745310010808	catalytic residue [active]
745310010809	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
745310010810	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
745310010811	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
745310010812	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310010813	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
745310010814	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
745310010815	Active Sites [active]
745310010816	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
745310010817	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
745310010818	CysD dimerization site [polypeptide binding]; other site
745310010819	G1 box; other site
745310010820	putative GEF interaction site [polypeptide binding]; other site
745310010821	GTP/Mg2+ binding site [chemical binding]; other site
745310010822	Switch I region; other site
745310010823	G2 box; other site
745310010824	G3 box; other site
745310010825	Switch II region; other site
745310010826	G4 box; other site
745310010827	G5 box; other site
745310010828	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
745310010829	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
745310010830	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
745310010831	ligand-binding site [chemical binding]; other site
745310010832	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
745310010833	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
745310010834	active site
745310010835	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
745310010836	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
745310010837	Sporulation related domain; Region: SPOR; pfam05036
745310010838	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
745310010839	Uncharacterized conserved protein [Function unknown]; Region: COG3791
745310010840	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
745310010841	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
745310010842	putative active site [active]
745310010843	catalytic triad [active]
745310010844	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
745310010845	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
745310010846	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
745310010847	ATP binding site [chemical binding]; other site
745310010848	active site
745310010849	substrate binding site [chemical binding]; other site
745310010850	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
745310010851	Domain of unknown function DUF20; Region: UPF0118; pfam01594
745310010852	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
745310010853	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
745310010854	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
745310010855	Cell division protein ZapA; Region: ZapA; pfam05164
745310010856	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
745310010857	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
745310010858	TPP-binding site [chemical binding]; other site
745310010859	dimer interface [polypeptide binding]; other site
745310010860	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
745310010861	PYR/PP interface [polypeptide binding]; other site
745310010862	dimer interface [polypeptide binding]; other site
745310010863	TPP binding site [chemical binding]; other site
745310010864	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
745310010865	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
745310010866	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
745310010867	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
745310010868	MOSC domain; Region: MOSC; pfam03473
745310010869	Phosphoglycerate kinase; Region: PGK; pfam00162
745310010870	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
745310010871	substrate binding site [chemical binding]; other site
745310010872	hinge regions; other site
745310010873	ADP binding site [chemical binding]; other site
745310010874	catalytic site [active]
745310010875	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
745310010876	dimer interface [polypeptide binding]; other site
745310010877	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
745310010878	metal binding site [ion binding]; metal-binding site
745310010879	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
745310010880	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
745310010881	putative active site; other site
745310010882	catalytic residue [active]
745310010883	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
745310010884	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
745310010885	thiamine phosphate binding site [chemical binding]; other site
745310010886	active site
745310010887	pyrophosphate binding site [ion binding]; other site
745310010888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
745310010889	Peptidase M15; Region: Peptidase_M15_3; cl01194
745310010890	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
745310010891	L11 interface [polypeptide binding]; other site
745310010892	putative EF-Tu interaction site [polypeptide binding]; other site
745310010893	putative EF-G interaction site [polypeptide binding]; other site
745310010894	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
745310010895	23S rRNA interface [nucleotide binding]; other site
745310010896	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
745310010897	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
745310010898	mRNA/rRNA interface [nucleotide binding]; other site
745310010899	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
745310010900	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
745310010901	23S rRNA interface [nucleotide binding]; other site
745310010902	L7/L12 interface [polypeptide binding]; other site
745310010903	putative thiostrepton binding site; other site
745310010904	L25 interface [polypeptide binding]; other site
745310010905	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
745310010906	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
745310010907	putative homodimer interface [polypeptide binding]; other site
745310010908	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
745310010909	heterodimer interface [polypeptide binding]; other site
745310010910	homodimer interface [polypeptide binding]; other site
745310010911	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
745310010912	PAS fold; Region: PAS_4; pfam08448
745310010913	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
745310010914	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
745310010915	metal binding site [ion binding]; metal-binding site
745310010916	active site
745310010917	I-site; other site
745310010918	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
745310010919	acyl-CoA synthetase; Validated; Region: PRK09192
745310010920	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
745310010921	acyl-activating enzyme (AAE) consensus motif; other site
745310010922	active site
745310010923	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
745310010924	DNA-binding site [nucleotide binding]; DNA binding site
745310010925	RNA-binding motif; other site
745310010926	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
745310010927	DNA-binding site [nucleotide binding]; DNA binding site
745310010928	RNA-binding motif; other site
745310010929	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
745310010930	NADH dehydrogenase; Validated; Region: PRK08183
745310010931	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
745310010932	mce related protein; Region: MCE; pfam02470
745310010933	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
745310010934	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
745310010935	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
745310010936	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310010937	P-loop; other site
745310010938	Magnesium ion binding site [ion binding]; other site
745310010939	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
745310010940	ArsC family; Region: ArsC; pfam03960
745310010941	catalytic residues [active]
745310010942	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
745310010943	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
745310010944	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
745310010945	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
745310010946	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
745310010947	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
745310010948	carboxyltransferase (CT) interaction site; other site
745310010949	biotinylation site [posttranslational modification]; other site
745310010950	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
745310010951	Dehydroquinase class II; Region: DHquinase_II; pfam01220
745310010952	trimer interface [polypeptide binding]; other site
745310010953	active site
745310010954	dimer interface [polypeptide binding]; other site
745310010955	bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840
745310010956	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
745310010957	thiS-thiF/thiG interaction site; other site
745310010958	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
745310010959	ThiS interaction site; other site
745310010960	putative active site [active]
745310010961	tetramer interface [polypeptide binding]; other site
745310010962	Protein of unknown function (DUF419); Region: DUF419; pfam04237
745310010963	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
745310010964	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
745310010965	active site
745310010966	substrate binding site [chemical binding]; other site
745310010967	cosubstrate binding site; other site
745310010968	catalytic site [active]
745310010969	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
745310010970	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
745310010971	dimerization interface [polypeptide binding]; other site
745310010972	putative ATP binding site [chemical binding]; other site
745310010973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310010974	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
745310010975	polyphosphate kinase; Provisional; Region: PRK05443
745310010976	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
745310010977	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
745310010978	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
745310010979	putative domain interface [polypeptide binding]; other site
745310010980	putative active site [active]
745310010981	catalytic site [active]
745310010982	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
745310010983	putative domain interface [polypeptide binding]; other site
745310010984	putative active site [active]
745310010985	catalytic site [active]
745310010986	exopolyphosphatase; Region: exo_poly_only; TIGR03706
745310010987	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
745310010988	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
745310010989	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
745310010990	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
745310010991	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
745310010992	catalytic site [active]
745310010993	putative active site [active]
745310010994	putative substrate binding site [chemical binding]; other site
745310010995	HRDC domain; Region: HRDC; pfam00570
745310010996	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
745310010997	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
745310010998	dimer interface [polypeptide binding]; other site
745310010999	anticodon binding site; other site
745310011000	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
745310011001	homodimer interface [polypeptide binding]; other site
745310011002	motif 1; other site
745310011003	active site
745310011004	motif 2; other site
745310011005	GAD domain; Region: GAD; pfam02938
745310011006	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
745310011007	active site
745310011008	motif 3; other site
745310011009	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
745310011010	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
745310011011	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
745310011012	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
745310011013	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310011014	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310011015	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310011016	catalytic residue [active]
745310011017	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
745310011018	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
745310011019	dimer interface [polypeptide binding]; other site
745310011020	active site
745310011021	catalytic residue [active]
745310011022	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
745310011023	SmpB-tmRNA interface; other site
745310011024	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
745310011025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310011026	dimer interface [polypeptide binding]; other site
745310011027	phosphorylation site [posttranslational modification]
745310011028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310011029	ATP binding site [chemical binding]; other site
745310011030	Mg2+ binding site [ion binding]; other site
745310011031	G-X-G motif; other site
745310011032	Response regulator receiver domain; Region: Response_reg; pfam00072
745310011033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310011034	active site
745310011035	phosphorylation site [posttranslational modification]
745310011036	intermolecular recognition site; other site
745310011037	dimerization interface [polypeptide binding]; other site
745310011038	response regulator; Provisional; Region: PRK13435
745310011039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310011040	phosphorylation site [posttranslational modification]
745310011041	recombinase A; Provisional; Region: recA; PRK09354
745310011042	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
745310011043	hexamer interface [polypeptide binding]; other site
745310011044	Walker A motif; other site
745310011045	ATP binding site [chemical binding]; other site
745310011046	Walker B motif; other site
745310011047	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
745310011048	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
745310011049	DNA binding residues [nucleotide binding]
745310011050	putative dimer interface [polypeptide binding]; other site
745310011051	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
745310011052	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310011053	active site
745310011054	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
745310011055	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
745310011056	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
745310011057	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992
745310011058	Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098
745310011059	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
745310011060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310011061	ATP binding site [chemical binding]; other site
745310011062	Mg2+ binding site [ion binding]; other site
745310011063	G-X-G motif; other site
745310011064	Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316
745310011065	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
745310011066	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
745310011067	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011068	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011069	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310011070	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
745310011071	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310011072	Walker A/P-loop; other site
745310011073	ATP binding site [chemical binding]; other site
745310011074	Q-loop/lid; other site
745310011075	ABC transporter signature motif; other site
745310011076	Walker B; other site
745310011077	D-loop; other site
745310011078	H-loop/switch region; other site
745310011079	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
745310011080	Domain of unknown function (DU1801); Region: DUF1801; cl17490
745310011081	Uncharacterized conserved protein [Function unknown]; Region: COG5649
745310011082	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
745310011083	Protein of unknown function (DUF419); Region: DUF419; cl15265
745310011084	recombination factor protein RarA; Reviewed; Region: PRK13342
745310011085	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310011086	Walker A motif; other site
745310011087	ATP binding site [chemical binding]; other site
745310011088	Walker B motif; other site
745310011089	arginine finger; other site
745310011090	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
745310011091	Predicted transcriptional regulators [Transcription]; Region: COG1695
745310011092	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
745310011093	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
745310011094	Uncharacterized conserved protein [Function unknown]; Region: COG2353
745310011095	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
745310011096	catalytic residues [active]
745310011097	dimer interface [polypeptide binding]; other site
745310011098	MarR family; Region: MarR_2; pfam12802
745310011099	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
745310011100	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
745310011101	dimer interface [polypeptide binding]; other site
745310011102	putative CheW interface [polypeptide binding]; other site
745310011103	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
745310011104	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
745310011105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310011106	DNA binding residues [nucleotide binding]
745310011107	dimerization interface [polypeptide binding]; other site
745310011108	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
745310011109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310011110	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
745310011111	NAD(P) binding site [chemical binding]; other site
745310011112	active site
745310011113	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
745310011114	classical (c) SDRs; Region: SDR_c; cd05233
745310011115	NAD(P) binding site [chemical binding]; other site
745310011116	active site
745310011117	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
745310011118	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
745310011119	active site
745310011120	FMN binding site [chemical binding]; other site
745310011121	substrate binding site [chemical binding]; other site
745310011122	putative catalytic residue [active]
745310011123	short chain dehydrogenase; Provisional; Region: PRK07890
745310011124	classical (c) SDRs; Region: SDR_c; cd05233
745310011125	NAD(P) binding site [chemical binding]; other site
745310011126	active site
745310011127	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310011128	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
745310011129	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
745310011130	Active Sites [active]
745310011131	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
745310011132	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
745310011133	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
745310011134	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
745310011135	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
745310011136	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
745310011137	active site
745310011138	SAM binding site [chemical binding]; other site
745310011139	homodimer interface [polypeptide binding]; other site
745310011140	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
745310011141	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
745310011142	NAD(P) binding site [chemical binding]; other site
745310011143	catalytic residues [active]
745310011144	hypothetical protein; Validated; Region: PRK00029
745310011145	Uncharacterized conserved protein [Function unknown]; Region: COG0397
745310011146	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
745310011147	acetyl-CoA synthetase; Provisional; Region: PRK00174
745310011148	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
745310011149	active site
745310011150	CoA binding site [chemical binding]; other site
745310011151	acyl-activating enzyme (AAE) consensus motif; other site
745310011152	AMP binding site [chemical binding]; other site
745310011153	acetate binding site [chemical binding]; other site
745310011154	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
745310011155	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
745310011156	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
745310011157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310011158	S-adenosylmethionine binding site [chemical binding]; other site
745310011159	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
745310011160	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
745310011161	GSH binding site [chemical binding]; other site
745310011162	catalytic residues [active]
745310011163	Predicted amidohydrolase [General function prediction only]; Region: COG0388
745310011164	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
745310011165	putative active site [active]
745310011166	catalytic triad [active]
745310011167	dimer interface [polypeptide binding]; other site
745310011168	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
745310011169	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
745310011170	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
745310011171	LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186
745310011172	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
745310011173	dimer interface [polypeptide binding]; other site
745310011174	substrate binding site [chemical binding]; other site
745310011175	phosphate binding site [ion binding]; other site
745310011176	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
745310011177	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
745310011178	dimer interaction site [polypeptide binding]; other site
745310011179	substrate-binding tunnel; other site
745310011180	active site
745310011181	catalytic site [active]
745310011182	substrate binding site [chemical binding]; other site
745310011183	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
745310011184	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310011185	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
745310011186	Cytochrome P450; Region: p450; cl12078
745310011187	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310011188	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011189	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310011190	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011191	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
745310011192	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
745310011193	NAD(P) binding site [chemical binding]; other site
745310011194	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
745310011195	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
745310011196	active site
745310011197	catalytic tetrad [active]
745310011198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
745310011199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310011200	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
745310011201	putative effector binding pocket; other site
745310011202	putative dimerization interface [polypeptide binding]; other site
745310011203	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
745310011204	Antirestriction protein (ArdA); Region: ArdA; pfam07275
745310011205	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
745310011206	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310011207	non-specific DNA binding site [nucleotide binding]; other site
745310011208	salt bridge; other site
745310011209	sequence-specific DNA binding site [nucleotide binding]; other site
745310011210	4Fe-4S binding domain; Region: Fer4; pfam00037
745310011211	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
745310011212	DNA methylase; Region: N6_N4_Mtase; cl17433
745310011213	DNA methylase; Region: N6_N4_Mtase; pfam01555
745310011214	DNA methylase; Region: N6_N4_Mtase; pfam01555
745310011215	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
745310011216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310011217	S-adenosylmethionine binding site [chemical binding]; other site
745310011218	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
745310011219	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310011220	DNA binding residues [nucleotide binding]
745310011221	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
745310011222	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310011223	Walker A motif; other site
745310011224	ATP binding site [chemical binding]; other site
745310011225	Walker B motif; other site
745310011226	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
745310011227	Transcriptional regulators [Transcription]; Region: MarR; COG1846
745310011228	MarR family; Region: MarR; pfam01047
745310011229	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011230	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
745310011231	catalytic residues [active]
745310011232	catalytic nucleophile [active]
745310011233	Recombinase; Region: Recombinase; pfam07508
745310011234	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
745310011235	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310011236	active site
745310011237	DNA binding site [nucleotide binding]
745310011238	Int/Topo IB signature motif; other site
745310011239	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310011240	DoxX-like family; Region: DoxX_2; pfam13564
745310011241	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
745310011242	muropeptide transporter; Validated; Region: ampG; cl17669
745310011243	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
745310011244	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
745310011245	Cupin domain; Region: Cupin_2; cl17218
745310011246	Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773
745310011247	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310011248	ligand-binding site [chemical binding]; other site
745310011249	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011250	Integrase core domain; Region: rve; pfam00665
745310011251	transposase/IS protein; Provisional; Region: PRK09183
745310011252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310011253	Walker A motif; other site
745310011254	ATP binding site [chemical binding]; other site
745310011255	Walker B motif; other site
745310011256	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
745310011257	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310011258	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
745310011259	dimer interface [polypeptide binding]; other site
745310011260	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
745310011261	multidrug efflux protein; Reviewed; Region: PRK09579
745310011262	Protein export membrane protein; Region: SecD_SecF; cl14618
745310011263	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310011264	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310011265	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
745310011266	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
745310011267	DNA binding residues [nucleotide binding]
745310011268	dimer interface [polypeptide binding]; other site
745310011269	[2Fe-2S] cluster binding site [ion binding]; other site
745310011270	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
745310011271	SapC; Region: SapC; pfam07277
745310011272	haemagglutination activity domain; Region: Haemagg_act; pfam05860
745310011273	Filamentous haemagglutinin family outer membrane protein; Region: DUF3739; pfam12545
745310011274	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
745310011275	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
745310011276	Domain of unknown function (DUF2341); Region: DUF2341; pfam10102
745310011277	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
745310011278	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
745310011279	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
745310011280	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
745310011281	Surface antigen; Region: Bac_surface_Ag; pfam01103
745310011282	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
745310011283	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
745310011284	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
745310011285	TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352
745310011286	Secretin and TonB N terminus short domain; Region: STN; smart00965
745310011287	Gram-negative bacterial tonB protein; Region: TonB; cl10048
745310011288	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
745310011289	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
745310011290	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
745310011291	FecR protein; Region: FecR; pfam04773
745310011292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310011293	sequence-specific DNA binding site [nucleotide binding]; other site
745310011294	salt bridge; other site
745310011295	HipA N-terminal domain; Region: Couple_hipA; pfam13657
745310011296	HipA-like N-terminal domain; Region: HipA_N; pfam07805
745310011297	HipA-like C-terminal domain; Region: HipA_C; pfam07804
745310011298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
745310011299	DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986
745310011300	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
745310011301	dimerization interface [polypeptide binding]; other site
745310011302	substrate binding pocket [chemical binding]; other site
745310011303	transposase/IS protein; Provisional; Region: PRK09183
745310011304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310011305	Walker A motif; other site
745310011306	ATP binding site [chemical binding]; other site
745310011307	Walker B motif; other site
745310011308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011309	Integrase core domain; Region: rve; pfam00665
745310011310	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
745310011311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
745310011312	S-adenosylmethionine binding site [chemical binding]; other site
745310011313	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
745310011314	Helicase_C-like; Region: Helicase_C_4; pfam13871
745310011315	RES domain; Region: RES; smart00953
745310011316	transposase/IS protein; Provisional; Region: PRK09183
745310011317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310011318	Walker A motif; other site
745310011319	ATP binding site [chemical binding]; other site
745310011320	Walker B motif; other site
745310011321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011322	Integrase core domain; Region: rve; pfam00665
745310011323	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
745310011324	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
745310011325	putative active site [active]
745310011326	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
745310011327	RNAase interaction site [polypeptide binding]; other site
745310011328	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
745310011329	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
745310011330	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
745310011331	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
745310011332	VirB7 interaction site; other site
745310011333	conjugal transfer protein TrbF; Provisional; Region: PRK13872
745310011334	conjugal transfer protein TrbL; Provisional; Region: PRK13875
745310011335	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
745310011336	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
745310011337	Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314
745310011338	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
745310011339	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
745310011340	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
745310011341	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310011342	Walker A motif; other site
745310011343	ATP binding site [chemical binding]; other site
745310011344	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
745310011345	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
745310011346	TrbC/VIRB2 family; Region: TrbC; cl01583
745310011347	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
745310011348	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
745310011349	Walker A motif; other site
745310011350	ATP binding site [chemical binding]; other site
745310011351	Walker B motif; other site
745310011352	Ribbon-helix-helix domain; Region: RHH_3; pfam12651
745310011353	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
745310011354	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
745310011355	Walker A motif; other site
745310011356	ATP binding site [chemical binding]; other site
745310011357	Walker B motif; other site
745310011358	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
745310011359	Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461
745310011360	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
745310011361	ATP binding site [chemical binding]; other site
745310011362	substrate interface [chemical binding]; other site
745310011363	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
745310011364	active site
745310011365	NTP binding site [chemical binding]; other site
745310011366	metal binding triad [ion binding]; metal-binding site
745310011367	Abortive infection C-terminus; Region: Abi_C; pfam14355
745310011368	DEAD-like helicases superfamily; Region: DEXDc; smart00487
745310011369	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
745310011370	ATP binding site [chemical binding]; other site
745310011371	putative Mg++ binding site [ion binding]; other site
745310011372	helicase superfamily c-terminal domain; Region: HELICc; smart00490
745310011373	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
745310011374	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
745310011375	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310011376	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310011377	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310011378	catalytic residue [active]
745310011379	Protein of unknown function (DUF736); Region: DUF736; pfam05284
745310011380	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
745310011381	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
745310011382	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
745310011383	ParA-like protein; Provisional; Region: PHA02518
745310011384	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310011385	P-loop; other site
745310011386	Magnesium ion binding site [ion binding]; other site
745310011387	Replication initiator protein A; Region: RPA; pfam10134
745310011388	Helix-turn-helix domain; Region: HTH_17; pfam12728
745310011389	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310011390	non-specific DNA binding site [nucleotide binding]; other site
745310011391	salt bridge; other site
745310011392	sequence-specific DNA binding site [nucleotide binding]; other site
745310011393	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
745310011394	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
745310011395	dimer interface [polypeptide binding]; other site
745310011396	ssDNA binding site [nucleotide binding]; other site
745310011397	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310011398	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
745310011399	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
745310011400	Catalytic site; other site
745310011401	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
745310011402	Toprim domain; Region: Toprim_3; pfam13362
745310011403	Methyltransferase domain; Region: Methyltransf_26; pfam13659
745310011404	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
745310011405	Helicase_C-like; Region: Helicase_C_4; pfam13871
745310011406	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
745310011407	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
745310011408	putative active site [active]
745310011409	ParB-like nuclease domain; Region: ParBc; cl02129
745310011410	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
745310011411	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310011412	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
745310011413	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310011414	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
745310011415	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310011416	DNA binding site [nucleotide binding]
745310011417	active site
745310011418	Int/Topo IB signature motif; other site
745310011419	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
745310011420	Uncharacterized conserved protein [Function unknown]; Region: COG2135
745310011421	Uncharacterized conserved protein [Function unknown]; Region: COG4544
745310011422	DNA Polymerase Y-family; Region: PolY_like; cd03468
745310011423	active site
745310011424	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
745310011425	DNA binding site [nucleotide binding]
745310011426	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
745310011427	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
745310011428	putative active site [active]
745310011429	putative PHP Thumb interface [polypeptide binding]; other site
745310011430	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
745310011431	generic binding surface II; other site
745310011432	generic binding surface I; other site
745310011433	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
745310011434	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
745310011435	DNA binding residues [nucleotide binding]
745310011436	dimer interface [polypeptide binding]; other site
745310011437	[2Fe-2S] cluster binding site [ion binding]; other site
745310011438	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310011439	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
745310011440	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310011441	multidrug efflux protein; Reviewed; Region: PRK09579
745310011442	Protein export membrane protein; Region: SecD_SecF; cl14618
745310011443	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
745310011444	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
745310011445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
745310011446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
745310011447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011448	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011449	Integrase core domain; Region: rve; pfam00665
745310011450	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
745310011451	Outer membrane efflux protein; Region: OEP; pfam02321
745310011452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011453	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011454	Integrase core domain; Region: rve; pfam00665
745310011455	glutathione reductase; Validated; Region: PRK06116
745310011456	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
745310011457	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
745310011458	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
745310011459	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
745310011460	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
745310011461	active site
745310011462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310011463	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
745310011464	NAD(P) binding site [chemical binding]; other site
745310011465	active site
745310011466	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
745310011467	NAD(P) binding site [chemical binding]; other site
745310011468	active site
745310011469	SnoaL-like domain; Region: SnoaL_4; pfam13577
745310011470	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
745310011471	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011472	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011473	Integrase core domain; Region: rve; pfam00665
745310011474	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
745310011475	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
745310011476	active site
745310011477	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
745310011478	Phosphotransferase enzyme family; Region: APH; pfam01636
745310011479	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
745310011480	putative active site [active]
745310011481	putative substrate binding site [chemical binding]; other site
745310011482	ATP binding site [chemical binding]; other site
745310011483	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
745310011484	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
745310011485	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
745310011486	NAD binding site [chemical binding]; other site
745310011487	catalytic Zn binding site [ion binding]; other site
745310011488	substrate binding site [chemical binding]; other site
745310011489	structural Zn binding site [ion binding]; other site
745310011490	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011491	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
745310011492	catalytic residues [active]
745310011493	catalytic nucleophile [active]
745310011494	Recombinase; Region: Recombinase; pfam07508
745310011495	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
745310011496	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310011497	DNA binding residues [nucleotide binding]
745310011498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011499	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310011500	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
745310011501	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
745310011502	N-terminal plug; other site
745310011503	ligand-binding site [chemical binding]; other site
745310011504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011505	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011506	Integrase core domain; Region: rve; pfam00665
745310011507	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
745310011508	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
745310011509	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
745310011510	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
745310011511	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
745310011512	TraU protein; Region: TraU; pfam06834
745310011513	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
745310011514	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
745310011515	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
745310011516	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
745310011517	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
745310011518	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
745310011519	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
745310011520	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
745310011521	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
745310011522	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
745310011523	dimerization domain [polypeptide binding]; other site
745310011524	dimer interface [polypeptide binding]; other site
745310011525	catalytic residues [active]
745310011526	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
745310011527	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
745310011528	TraK protein; Region: TraK; pfam06586
745310011529	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
745310011530	TraE protein; Region: TraE; cl05060
745310011531	TraL protein; Region: TraL; pfam07178
745310011532	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
745310011533	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
745310011534	N-acetyl-D-glucosamine binding site [chemical binding]; other site
745310011535	catalytic residue [active]
745310011536	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011537	Integrase core domain; Region: rve; pfam00665
745310011538	transposase/IS protein; Provisional; Region: PRK09183
745310011539	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
745310011540	Walker A motif; other site
745310011541	ATP binding site [chemical binding]; other site
745310011542	Walker B motif; other site
745310011543	Predicted transcriptional regulator [Transcription]; Region: COG3905
745310011544	Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373
745310011545	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
745310011546	dihydropteroate synthase; Region: DHPS; TIGR01496
745310011547	substrate binding pocket [chemical binding]; other site
745310011548	dimer interface [polypeptide binding]; other site
745310011549	inhibitor binding site; inhibition site
745310011550	TniQ; Region: TniQ; pfam06527
745310011551	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310011552	AAA domain; Region: AAA_22; pfam13401
745310011553	Walker A motif; other site
745310011554	ATP binding site [chemical binding]; other site
745310011555	Walker B motif; other site
745310011556	arginine finger; other site
745310011557	Integrase core domain; Region: rve; pfam00665
745310011558	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
745310011559	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
745310011560	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
745310011561	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
745310011562	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
745310011563	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
745310011564	motif II; other site
745310011565	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
745310011566	Transposase; Region: HTH_Tnp_1; pfam01527
745310011567	putative transposase OrfB; Reviewed; Region: PHA02517
745310011568	HTH-like domain; Region: HTH_21; pfam13276
745310011569	Integrase core domain; Region: rve; pfam00665
745310011570	Integrase core domain; Region: rve_3; pfam13683
745310011571	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
745310011572	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
745310011573	active site
745310011574	substrate-binding site [chemical binding]; other site
745310011575	metal-binding site [ion binding]
745310011576	ATP binding site [chemical binding]; other site
745310011577	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310011578	non-specific DNA binding site [nucleotide binding]; other site
745310011579	salt bridge; other site
745310011580	sequence-specific DNA binding site [nucleotide binding]; other site
745310011581	putative transporter; Provisional; Region: PRK11660
745310011582	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
745310011583	Sulfate transporter family; Region: Sulfate_transp; pfam00916
745310011584	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
745310011585	beta-ketothiolase; Provisional; Region: PRK09051
745310011586	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
745310011587	dimer interface [polypeptide binding]; other site
745310011588	active site
745310011589	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
745310011590	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
745310011591	PhnA protein; Region: PhnA; pfam03831
745310011592	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
745310011593	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
745310011594	non-specific DNA binding site [nucleotide binding]; other site
745310011595	salt bridge; other site
745310011596	sequence-specific DNA binding site [nucleotide binding]; other site
745310011597	HipA N-terminal domain; Region: Couple_hipA; cl11853
745310011598	HipA-like N-terminal domain; Region: HipA_N; pfam07805
745310011599	HipA-like C-terminal domain; Region: HipA_C; pfam07804
745310011600	potential frameshift: common BLAST hit: gi|294010537|ref|YP_003543997.1| Tn3-family transposase
745310011601	potential protein location (hypothetical protein) that overlaps protein (Transposase)
745310011602	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011603	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011604	catalytic residues [active]
745310011605	catalytic nucleophile [active]
745310011606	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011607	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011608	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011609	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011610	DNA binding site [nucleotide binding]
745310011611	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310011612	DNA-binding interface [nucleotide binding]; DNA binding site
745310011613	Mechanosensitive ion channel; Region: MS_channel; pfam00924
745310011614	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
745310011615	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
745310011616	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
745310011617	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
745310011618	peroxiredoxin; Provisional; Region: PRK13189
745310011619	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
745310011620	dimer interface [polypeptide binding]; other site
745310011621	decamer (pentamer of dimers) interface [polypeptide binding]; other site
745310011622	catalytic triad [active]
745310011623	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
745310011624	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
745310011625	catalytic residues [active]
745310011626	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
745310011627	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
745310011628	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310011629	dimerization interface [polypeptide binding]; other site
745310011630	putative DNA binding site [nucleotide binding]; other site
745310011631	putative Zn2+ binding site [ion binding]; other site
745310011632	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310011633	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
745310011634	Walker A/P-loop; other site
745310011635	ATP binding site [chemical binding]; other site
745310011636	Q-loop/lid; other site
745310011637	ABC transporter signature motif; other site
745310011638	Walker B; other site
745310011639	D-loop; other site
745310011640	H-loop/switch region; other site
745310011641	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
745310011642	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
745310011643	Walker A/P-loop; other site
745310011644	ATP binding site [chemical binding]; other site
745310011645	Q-loop/lid; other site
745310011646	ABC transporter signature motif; other site
745310011647	Walker B; other site
745310011648	D-loop; other site
745310011649	H-loop/switch region; other site
745310011650	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
745310011651	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
745310011652	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
745310011653	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
745310011654	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
745310011655	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
745310011656	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
745310011657	catalytic residues [active]
745310011658	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
745310011659	diiron binding motif [ion binding]; other site
745310011660	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
745310011661	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
745310011662	dimerization interface [polypeptide binding]; other site
745310011663	putative DNA binding site [nucleotide binding]; other site
745310011664	putative Zn2+ binding site [ion binding]; other site
745310011665	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
745310011666	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
745310011667	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
745310011668	HlyD family secretion protein; Region: HlyD_3; pfam13437
745310011669	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
745310011670	active site residue [active]
745310011671	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
745310011672	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
745310011673	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
745310011674	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
745310011675	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
745310011676	active site
745310011677	DNA binding site [nucleotide binding]
745310011678	Int/Topo IB signature motif; other site
745310011679	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
745310011680	Coenzyme A binding pocket [chemical binding]; other site
745310011681	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
745310011682	putative active site [active]
745310011683	Replication initiator protein A; Region: RPA; pfam10134
745310011684	ParB-like nuclease domain; Region: ParBc; pfam02195
745310011685	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
745310011686	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
745310011687	DNA binding residues [nucleotide binding]
745310011688	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310011689	P-loop; other site
745310011690	Magnesium ion binding site [ion binding]; other site
745310011691	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310011692	Magnesium ion binding site [ion binding]; other site
745310011693	CHC2 zinc finger; Region: zf-CHC2; cl17510
745310011694	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
745310011695	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011696	Integrase core domain; Region: rve; pfam00665
745310011697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
745310011698	Walker A motif; other site
745310011699	ATP binding site [chemical binding]; other site
745310011700	Walker B motif; other site
745310011701	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
745310011702	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
745310011703	Protein of unknown function (DUF736); Region: DUF736; pfam05284
745310011704	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
745310011705	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
745310011706	dimer interface [polypeptide binding]; other site
745310011707	ssDNA binding site [nucleotide binding]; other site
745310011708	tetramer (dimer of dimers) interface [polypeptide binding]; other site
745310011709	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
745310011710	bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412
745310011711	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
745310011712	Integrase core domain; Region: rve; pfam00665
745310011713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
745310011714	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
745310011715	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
745310011716	putative dimer interface [polypeptide binding]; other site
745310011717	Predicted membrane protein [Function unknown]; Region: COG3174
745310011718	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
745310011719	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310011720	PAS domain; Region: PAS_9; pfam13426
745310011721	putative active site [active]
745310011722	heme pocket [chemical binding]; other site
745310011723	PAS domain S-box; Region: sensory_box; TIGR00229
745310011724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
745310011725	putative active site [active]
745310011726	heme pocket [chemical binding]; other site
745310011727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
745310011728	dimer interface [polypeptide binding]; other site
745310011729	phosphorylation site [posttranslational modification]
745310011730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
745310011731	ATP binding site [chemical binding]; other site
745310011732	Mg2+ binding site [ion binding]; other site
745310011733	G-X-G motif; other site
745310011734	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
745310011735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310011736	active site
745310011737	phosphorylation site [posttranslational modification]
745310011738	intermolecular recognition site; other site
745310011739	dimerization interface [polypeptide binding]; other site
745310011740	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
745310011741	DNA binding residues [nucleotide binding]
745310011742	dimerization interface [polypeptide binding]; other site
745310011743	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
745310011744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
745310011745	active site
745310011746	phosphorylation site [posttranslational modification]
745310011747	intermolecular recognition site; other site
745310011748	dimerization interface [polypeptide binding]; other site
745310011749	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
745310011750	heme-binding site [chemical binding]; other site
745310011751	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
745310011752	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
745310011753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011754	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011755	Integrase core domain; Region: rve; pfam00665
745310011756	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011757	short chain dehydrogenase; Provisional; Region: PRK06172
745310011758	classical (c) SDRs; Region: SDR_c; cd05233
745310011759	NAD(P) binding site [chemical binding]; other site
745310011760	active site
745310011761	EthD domain; Region: EthD; pfam07110
745310011762	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011763	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011764	Integrase core domain; Region: rve; pfam00665
745310011765	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
745310011766	metal binding site [ion binding]; metal-binding site
745310011767	Predicted esterase [General function prediction only]; Region: COG0400
745310011768	Serine hydrolase (FSH1); Region: FSH1; pfam03959
745310011769	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
745310011770	C-terminal domain interface [polypeptide binding]; other site
745310011771	GSH binding site (G-site) [chemical binding]; other site
745310011772	dimer interface [polypeptide binding]; other site
745310011773	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011774	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011775	Integrase core domain; Region: rve; pfam00665
745310011776	Integrase core domain; Region: rve; pfam00665
745310011777	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310011778	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011779	catalytic residues [active]
745310011780	catalytic nucleophile [active]
745310011781	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011782	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011783	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011784	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011785	DNA binding site [nucleotide binding]
745310011786	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310011787	DNA-binding interface [nucleotide binding]; DNA binding site
745310011788	ParA-like protein; Provisional; Region: PHA02518
745310011789	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310011790	Magnesium ion binding site [ion binding]; other site
745310011791	Initiator Replication protein; Region: Rep_3; pfam01051
745310011792	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
745310011793	Predicted ATPase [General function prediction only]; Region: COG3911
745310011794	AAA domain; Region: AAA_28; pfam13521
745310011795	Conjugal transfer protein TraD; Region: TraD; pfam06412
745310011796	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
745310011797	MobA/MobL family; Region: MobA_MobL; pfam03389
745310011798	AAA domain; Region: AAA_30; pfam13604
745310011799	Family description; Region: UvrD_C_2; pfam13538
745310011800	DDE domain; Region: DDE_Tnp_IS240; pfam13610
745310011801	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011802	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011803	catalytic residues [active]
745310011804	catalytic nucleophile [active]
745310011805	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011806	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011807	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011808	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011809	DNA binding site [nucleotide binding]
745310011810	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310011811	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310011812	Initiator Replication protein; Region: Rep_3; pfam01051
745310011813	ParA-like protein; Provisional; Region: PHA02518
745310011814	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
745310011815	Magnesium ion binding site [ion binding]; other site
745310011816	multiple promoter invertase; Provisional; Region: mpi; PRK13413
745310011817	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011818	catalytic residues [active]
745310011819	catalytic nucleophile [active]
745310011820	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011821	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011822	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011823	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011824	DNA binding site [nucleotide binding]
745310011825	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
745310011826	DNA-binding interface [nucleotide binding]; DNA binding site
745310011827	Integrase core domain; Region: rve; pfam00665
745310011828	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011829	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011830	Integrase core domain; Region: rve; pfam00665
745310011831	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
745310011832	C-terminal domain interface [polypeptide binding]; other site
745310011833	GSH binding site (G-site) [chemical binding]; other site
745310011834	dimer interface [polypeptide binding]; other site
745310011835	Predicted esterase [General function prediction only]; Region: COG0400
745310011836	Serine hydrolase (FSH1); Region: FSH1; pfam03959
745310011837	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
745310011838	metal binding site [ion binding]; metal-binding site
745310011839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011840	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011841	Integrase core domain; Region: rve; pfam00665
745310011842	EthD domain; Region: EthD; pfam07110
745310011843	short chain dehydrogenase; Provisional; Region: PRK06172
745310011844	classical (c) SDRs; Region: SDR_c; cd05233
745310011845	NAD(P) binding site [chemical binding]; other site
745310011846	active site
745310011847	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
745310011848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011849	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011850	Integrase core domain; Region: rve; pfam00665
745310011851	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
745310011852	active site
745310011853	substrate binding site [chemical binding]; other site
745310011854	alpha subunit interface [polypeptide binding]; other site
745310011855	classical (c) SDRs; Region: SDR_c; cd05233
745310011856	NAD(P) binding site [chemical binding]; other site
745310011857	active site
745310011858	EthD domain; Region: EthD; pfam07110
745310011859	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
745310011860	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
745310011861	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
745310011862	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
745310011863	Protein of unknown function (DUF497); Region: DUF497; pfam04365
745310011864	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011865	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011866	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011867	catalytic residues [active]
745310011868	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011869	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011870	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011871	DNA binding site [nucleotide binding]
745310011872	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
745310011873	DNA-binding interface [nucleotide binding]; DNA binding site
745310011874	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011875	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
745310011876	Integrase core domain; Region: rve; pfam00665
745310011877	haloalkane dehalogenase; Provisional; Region: PRK03592
745310011878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
745310011879	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
745310011880	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
745310011881	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
745310011882	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
745310011883	catalytic residues [active]
745310011884	catalytic nucleophile [active]
745310011885	Presynaptic Site I dimer interface [polypeptide binding]; other site
745310011886	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
745310011887	Synaptic Flat tetramer interface [polypeptide binding]; other site
745310011888	Synaptic Site I dimer interface [polypeptide binding]; other site
745310011889	DNA binding site [nucleotide binding]
745310011890	DDE domain; Region: DDE_Tnp_IS240; pfam13610
745310011891	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
745310011892	MobA/MobL family; Region: MobA_MobL; pfam03389
745310011893	AAA domain; Region: AAA_30; pfam13604
745310011894	Family description; Region: UvrD_C_2; pfam13538
745310011895	Conjugal transfer protein TraD; Region: TraD; pfam06412
745310011896	Predicted ATPase [General function prediction only]; Region: COG3911
745310011897	AAA domain; Region: AAA_28; pfam13521
745310011898	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505