-- dump date   	20140620_072052
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
317655000001	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
317655000002	MobA/MobL family; Region: MobA_MobL; pfam03389
317655000003	AAA domain; Region: AAA_30; pfam13604
317655000004	Family description; Region: UvrD_C_2; pfam13538
317655000005	Conjugal transfer protein TraD; Region: TraD; pfam06412
317655000006	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
317655000007	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
317655000008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655000009	active site
317655000010	phosphorylation site [posttranslational modification]
317655000011	intermolecular recognition site; other site
317655000012	dimerization interface [polypeptide binding]; other site
317655000013	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000014	Walker A motif; other site
317655000015	ATP binding site [chemical binding]; other site
317655000016	Walker B motif; other site
317655000017	arginine finger; other site
317655000018	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655000019	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
317655000020	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
317655000021	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
317655000022	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
317655000023	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
317655000024	nickel binding site [ion binding]; other site
317655000025	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
317655000026	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
317655000027	iron-sulfur cluster [ion binding]; other site
317655000028	[2Fe-2S] cluster binding site [ion binding]; other site
317655000029	NHL repeat; Region: NHL; pfam01436
317655000030	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
317655000031	Acylphosphatase; Region: Acylphosphatase; pfam00708
317655000032	HypF finger; Region: zf-HYPF; pfam07503
317655000033	HypF finger; Region: zf-HYPF; pfam07503
317655000034	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
317655000035	HupF/HypC family; Region: HupF_HypC; cl00394
317655000036	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
317655000037	dimer interface [polypeptide binding]; other site
317655000038	active site
317655000039	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
317655000040	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
317655000041	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
317655000042	dimerization interface [polypeptide binding]; other site
317655000043	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
317655000044	ATP binding site [chemical binding]; other site
317655000045	High-affinity nickel-transport protein; Region: NicO; cl00964
317655000046	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
317655000047	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
317655000048	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
317655000049	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655000050	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655000051	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655000052	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655000053	acyl-activating enzyme (AAE) consensus motif; other site
317655000054	acyl-activating enzyme (AAE) consensus motif; other site
317655000055	putative AMP binding site [chemical binding]; other site
317655000056	putative active site [active]
317655000057	putative CoA binding site [chemical binding]; other site
317655000058	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
317655000059	DnaA N-terminal domain; Region: DnaA_N; pfam11638
317655000060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000061	Walker A motif; other site
317655000062	ATP binding site [chemical binding]; other site
317655000063	Walker B motif; other site
317655000064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
317655000065	arginine finger; other site
317655000066	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
317655000067	DnaA box-binding interface [nucleotide binding]; other site
317655000068	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655000069	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
317655000070	putative C-terminal domain interface [polypeptide binding]; other site
317655000071	putative GSH binding site (G-site) [chemical binding]; other site
317655000072	putative dimer interface [polypeptide binding]; other site
317655000073	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
317655000074	putative substrate binding pocket (H-site) [chemical binding]; other site
317655000075	putative N-terminal domain interface [polypeptide binding]; other site
317655000076	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
317655000077	G1 box; other site
317655000078	GTP/Mg2+ binding site [chemical binding]; other site
317655000079	Switch I region; other site
317655000080	G2 box; other site
317655000081	G3 box; other site
317655000082	Switch II region; other site
317655000083	G4 box; other site
317655000084	G5 box; other site
317655000085	membrane protein insertase; Provisional; Region: PRK01318
317655000086	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
317655000087	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
317655000088	Haemolytic domain; Region: Haemolytic; pfam01809
317655000089	Ribonuclease P; Region: Ribonuclease_P; pfam00825
317655000090	Predicted small secreted protein [Function unknown]; Region: COG5510
317655000091	Predicted periplasmic protein [Function unknown]; Region: COG3904
317655000092	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655000093	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
317655000094	C-terminal domain interface [polypeptide binding]; other site
317655000095	GSH binding site (G-site) [chemical binding]; other site
317655000096	dimer interface [polypeptide binding]; other site
317655000097	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
317655000098	N-terminal domain interface [polypeptide binding]; other site
317655000099	dimer interface [polypeptide binding]; other site
317655000100	substrate binding pocket (H-site) [chemical binding]; other site
317655000101	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
317655000102	dimer interface [polypeptide binding]; other site
317655000103	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655000104	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
317655000105	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
317655000106	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655000107	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655000108	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
317655000109	putative C-terminal domain interface [polypeptide binding]; other site
317655000110	putative GSH binding site (G-site) [chemical binding]; other site
317655000111	putative dimer interface [polypeptide binding]; other site
317655000112	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
317655000113	dimer interface [polypeptide binding]; other site
317655000114	N-terminal domain interface [polypeptide binding]; other site
317655000115	putative substrate binding pocket (H-site) [chemical binding]; other site
317655000116	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
317655000117	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
317655000118	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
317655000119	putative C-terminal domain interface [polypeptide binding]; other site
317655000120	putative GSH binding site (G-site) [chemical binding]; other site
317655000121	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655000122	putative dimer interface [polypeptide binding]; other site
317655000123	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
317655000124	dimer interface [polypeptide binding]; other site
317655000125	N-terminal domain interface [polypeptide binding]; other site
317655000126	putative substrate binding pocket (H-site) [chemical binding]; other site
317655000127	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655000128	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
317655000129	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
317655000130	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
317655000131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655000132	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000133	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000134	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
317655000135	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
317655000136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000137	Walker A motif; other site
317655000138	ATP binding site [chemical binding]; other site
317655000139	Walker B motif; other site
317655000140	arginine finger; other site
317655000141	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
317655000142	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
317655000143	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655000144	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655000145	metal binding site [ion binding]; metal-binding site
317655000146	active site
317655000147	I-site; other site
317655000148	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
317655000149	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
317655000150	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655000151	Phospholipid methyltransferase; Region: PEMT; cl17370
317655000152	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655000153	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655000154	N-terminal plug; other site
317655000155	ligand-binding site [chemical binding]; other site
317655000156	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
317655000157	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
317655000158	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
317655000159	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655000160	N-terminal plug; other site
317655000161	ligand-binding site [chemical binding]; other site
317655000162	patatin-related protein; Region: TIGR03607
317655000163	Patatin-like phospholipase; Region: Patatin; pfam01734
317655000164	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
317655000165	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
317655000166	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
317655000167	conserved cys residue [active]
317655000168	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655000169	dimerization interface [polypeptide binding]; other site
317655000170	putative DNA binding site [nucleotide binding]; other site
317655000171	putative Zn2+ binding site [ion binding]; other site
317655000172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655000173	S-adenosylmethionine binding site [chemical binding]; other site
317655000174	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
317655000175	FAD binding site [chemical binding]; other site
317655000176	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
317655000177	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
317655000178	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
317655000179	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
317655000180	substrate binding pocket [chemical binding]; other site
317655000181	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
317655000182	B12 binding site [chemical binding]; other site
317655000183	cobalt ligand [ion binding]; other site
317655000184	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
317655000185	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
317655000186	Membrane fusogenic activity; Region: BMFP; pfam04380
317655000187	TspO/MBR family; Region: TspO_MBR; pfam03073
317655000188	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
317655000189	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655000190	RNA binding surface [nucleotide binding]; other site
317655000191	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655000192	S-adenosylmethionine binding site [chemical binding]; other site
317655000193	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
317655000194	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
317655000195	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
317655000196	DsbD alpha interface [polypeptide binding]; other site
317655000197	catalytic residues [active]
317655000198	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
317655000199	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
317655000200	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
317655000201	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
317655000202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655000203	dimerization interface [polypeptide binding]; other site
317655000204	putative DNA binding site [nucleotide binding]; other site
317655000205	putative Zn2+ binding site [ion binding]; other site
317655000206	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
317655000207	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
317655000208	homodimer interface [polypeptide binding]; other site
317655000209	substrate-cofactor binding pocket; other site
317655000210	catalytic residue [active]
317655000211	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655000212	active site
317655000213	DNA binding site [nucleotide binding]
317655000214	Int/Topo IB signature motif; other site
317655000215	P-loop containing region of AAA domain; Region: AAA_29; cl17516
317655000216	AAA domain; Region: AAA_27; pfam13514
317655000217	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
317655000218	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
317655000219	active site
317655000220	metal binding site [ion binding]; metal-binding site
317655000221	DNA binding site [nucleotide binding]
317655000222	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
317655000223	Part of AAA domain; Region: AAA_19; pfam13245
317655000224	Family description; Region: UvrD_C_2; pfam13538
317655000225	Amidohydrolase; Region: Amidohydro_2; pfam04909
317655000226	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
317655000227	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
317655000228	Putative transposase; Region: Y2_Tnp; pfam04986
317655000229	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
317655000230	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
317655000231	Int/Topo IB signature motif; other site
317655000232	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
317655000233	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
317655000234	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
317655000235	catalytic residues [active]
317655000236	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655000237	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000239	short chain dehydrogenase; Provisional; Region: PRK06180
317655000240	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
317655000241	NADP binding site [chemical binding]; other site
317655000242	active site
317655000243	steroid binding site; other site
317655000244	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
317655000245	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
317655000246	Epoxide hydrolase N terminus; Region: EHN; pfam06441
317655000247	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655000248	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
317655000249	classical (c) SDRs; Region: SDR_c; cd05233
317655000250	NAD(P) binding site [chemical binding]; other site
317655000251	active site
317655000252	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655000253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655000254	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
317655000255	putative effector binding pocket; other site
317655000256	putative dimerization interface [polypeptide binding]; other site
317655000257	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000258	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000259	oxidoreductase; Provisional; Region: PRK12742
317655000260	classical (c) SDRs; Region: SDR_c; cd05233
317655000261	NAD(P) binding site [chemical binding]; other site
317655000262	active site
317655000263	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
317655000264	Tetratricopeptide repeat; Region: TPR_9; pfam13371
317655000265	Thioredoxin-like; Region: Thioredoxin_7; pfam13899
317655000266	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
317655000267	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
317655000268	tetramer (dimer of dimers) interface [polypeptide binding]; other site
317655000269	active site
317655000270	dimer interface [polypeptide binding]; other site
317655000271	Transcriptional regulators [Transcription]; Region: MarR; COG1846
317655000272	MarR family; Region: MarR_2; cl17246
317655000273	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000275	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
317655000276	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
317655000277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655000278	NAD(P) binding site [chemical binding]; other site
317655000279	active site
317655000280	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655000281	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655000282	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
317655000283	dimerization interface [polypeptide binding]; other site
317655000284	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
317655000285	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
317655000286	C-terminal domain interface [polypeptide binding]; other site
317655000287	GSH binding site (G-site) [chemical binding]; other site
317655000288	dimer interface [polypeptide binding]; other site
317655000289	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
317655000290	dimer interface [polypeptide binding]; other site
317655000291	N-terminal domain interface [polypeptide binding]; other site
317655000292	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
317655000293	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
317655000294	oligomer interface [polypeptide binding]; other site
317655000295	metal binding site [ion binding]; metal-binding site
317655000296	metal binding site [ion binding]; metal-binding site
317655000297	putative Cl binding site [ion binding]; other site
317655000298	basic sphincter; other site
317655000299	hydrophobic gate; other site
317655000300	periplasmic entrance; other site
317655000301	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655000302	Electron transfer DM13; Region: DM13; cl02735
317655000303	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
317655000304	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
317655000305	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
317655000306	Domain of unknown function (DUF336); Region: DUF336; cl01249
317655000307	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
317655000308	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
317655000309	putative NAD(P) binding site [chemical binding]; other site
317655000310	dimer interface [polypeptide binding]; other site
317655000311	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
317655000312	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
317655000313	Moco binding site; other site
317655000314	metal coordination site [ion binding]; other site
317655000315	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
317655000316	FAD binding pocket [chemical binding]; other site
317655000317	conserved FAD binding motif [chemical binding]; other site
317655000318	phosphate binding motif [ion binding]; other site
317655000319	beta-alpha-beta structure motif; other site
317655000320	NAD binding pocket [chemical binding]; other site
317655000321	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
317655000322	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655000323	dimer interface [polypeptide binding]; other site
317655000324	active site
317655000325	Domain of unknown function (DUF427); Region: DUF427; pfam04248
317655000326	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
317655000327	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
317655000328	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
317655000329	active site
317655000330	HIGH motif; other site
317655000331	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655000332	KMSK motif region; other site
317655000333	tRNA binding surface [nucleotide binding]; other site
317655000334	DALR anticodon binding domain; Region: DALR_1; smart00836
317655000335	anticodon binding site; other site
317655000336	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
317655000337	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
317655000338	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
317655000339	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655000340	MarR family; Region: MarR; pfam01047
317655000341	Protein of unknown function, DUF417; Region: DUF417; cl01162
317655000342	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
317655000343	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655000344	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655000345	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655000346	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655000347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655000348	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
317655000349	putative effector binding pocket; other site
317655000350	dimerization interface [polypeptide binding]; other site
317655000351	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
317655000352	putative catalytic residues [active]
317655000353	methionine sulfoxide reductase B; Provisional; Region: PRK00222
317655000354	SelR domain; Region: SelR; pfam01641
317655000355	methionine sulfoxide reductase A; Provisional; Region: PRK14054
317655000356	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
317655000357	GSH binding site [chemical binding]; other site
317655000358	catalytic residues [active]
317655000359	Cation efflux family; Region: Cation_efflux; cl00316
317655000360	YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198
317655000361	homotrimer interaction site [polypeptide binding]; other site
317655000362	putative active site [active]
317655000363	Cytochrome c; Region: Cytochrom_C; cl11414
317655000364	Staphylococcal nuclease homologues; Region: SNc; smart00318
317655000365	Catalytic site; other site
317655000366	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
317655000367	Excalibur calcium-binding domain; Region: Excalibur; smart00894
317655000368	MobA/MobL family; Region: MobA_MobL; pfam03389
317655000369	Methyltransferase domain; Region: Methyltransf_26; pfam13659
317655000370	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
317655000371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655000372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655000373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655000374	S-adenosylmethionine binding site [chemical binding]; other site
317655000375	rhodanese superfamily protein; Provisional; Region: PRK05320
317655000376	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
317655000377	active site residue [active]
317655000378	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
317655000379	Nitrogen regulatory protein P-II; Region: P-II; smart00938
317655000380	glutamine synthetase; Provisional; Region: glnA; PRK09469
317655000381	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
317655000382	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
317655000383	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655000384	non-specific DNA binding site [nucleotide binding]; other site
317655000385	salt bridge; other site
317655000386	sequence-specific DNA binding site [nucleotide binding]; other site
317655000387	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
317655000388	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
317655000389	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655000390	NAD binding site [chemical binding]; other site
317655000391	catalytic residues [active]
317655000392	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
317655000393	heterotetramer interface [polypeptide binding]; other site
317655000394	active site pocket [active]
317655000395	cleavage site
317655000396	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
317655000397	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
317655000398	catalytic residues [active]
317655000399	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
317655000400	Family description; Region: UvrD_C_2; pfam13538
317655000401	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
317655000402	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
317655000403	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
317655000404	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
317655000405	Substrate binding site; other site
317655000406	metal-binding site
317655000407	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
317655000408	Phosphotransferase enzyme family; Region: APH; pfam01636
317655000409	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
317655000410	PAS fold; Region: PAS_7; pfam12860
317655000411	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
317655000412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655000413	dimer interface [polypeptide binding]; other site
317655000414	phosphorylation site [posttranslational modification]
317655000415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655000416	ATP binding site [chemical binding]; other site
317655000417	Mg2+ binding site [ion binding]; other site
317655000418	G-X-G motif; other site
317655000419	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
317655000420	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
317655000421	homotetramer interface [polypeptide binding]; other site
317655000422	ligand binding site [chemical binding]; other site
317655000423	catalytic site [active]
317655000424	NAD binding site [chemical binding]; other site
317655000425	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
317655000426	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
317655000427	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
317655000428	catalytic triad [active]
317655000429	dimer interface [polypeptide binding]; other site
317655000430	AMP nucleosidase; Provisional; Region: PRK08292
317655000431	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
317655000432	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
317655000433	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
317655000434	Clp amino terminal domain; Region: Clp_N; pfam02861
317655000435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000436	Walker A motif; other site
317655000437	ATP binding site [chemical binding]; other site
317655000438	Walker B motif; other site
317655000439	arginine finger; other site
317655000440	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000441	Walker A motif; other site
317655000442	ATP binding site [chemical binding]; other site
317655000443	Walker B motif; other site
317655000444	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
317655000445	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
317655000446	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
317655000447	acyl-activating enzyme (AAE) consensus motif; other site
317655000448	putative AMP binding site [chemical binding]; other site
317655000449	putative active site [active]
317655000450	putative CoA binding site [chemical binding]; other site
317655000451	aminodeoxychorismate synthase; Provisional; Region: PRK07508
317655000452	chorismate binding enzyme; Region: Chorismate_bind; cl10555
317655000453	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
317655000454	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
317655000455	substrate-cofactor binding pocket; other site
317655000456	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655000457	homodimer interface [polypeptide binding]; other site
317655000458	catalytic residue [active]
317655000459	aspartate aminotransferase; Provisional; Region: PRK05764
317655000460	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
317655000461	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655000462	homodimer interface [polypeptide binding]; other site
317655000463	catalytic residue [active]
317655000464	methionine sulfoxide reductase A; Provisional; Region: PRK13014
317655000465	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
317655000466	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
317655000467	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
317655000468	CoA-ligase; Region: Ligase_CoA; pfam00549
317655000469	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
317655000470	Ligand binding site [chemical binding]; other site
317655000471	Electron transfer flavoprotein domain; Region: ETF; pfam01012
317655000472	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
317655000473	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
317655000474	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
317655000475	Domain of unknown function (DUF389); Region: DUF389; pfam04087
317655000476	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
317655000477	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655000478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655000479	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
317655000480	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
317655000481	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
317655000482	active site
317655000483	catalytic site [active]
317655000484	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
317655000485	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
317655000486	active site
317655000487	catalytic site [active]
317655000488	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
317655000489	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
317655000490	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
317655000491	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
317655000492	putative molybdopterin cofactor binding site [chemical binding]; other site
317655000493	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
317655000494	putative molybdopterin cofactor binding site; other site
317655000495	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
317655000496	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
317655000497	GTP binding site; other site
317655000498	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
317655000499	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
317655000500	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
317655000501	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
317655000502	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
317655000503	phosphogluconate dehydratase; Validated; Region: PRK09054
317655000504	6-phosphogluconate dehydratase; Region: edd; TIGR01196
317655000505	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
317655000506	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
317655000507	active site
317655000508	intersubunit interface [polypeptide binding]; other site
317655000509	catalytic residue [active]
317655000510	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
317655000511	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
317655000512	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
317655000513	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
317655000514	putative acyl-acceptor binding pocket; other site
317655000515	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
317655000516	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
317655000517	putative acyl-acceptor binding pocket; other site
317655000518	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
317655000519	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
317655000520	Triacylglycerol lipase 3, 4, and 5 and Sugar-Dependent 1 lipase; Region: Pat_TGL3-4-5_SDP1; cd07206
317655000521	active site
317655000522	nucleophile elbow; other site
317655000523	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
317655000524	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655000525	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655000526	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
317655000527	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439
317655000528	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
317655000529	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
317655000530	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
317655000531	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
317655000532	catalytic residues [active]
317655000533	argininosuccinate lyase; Provisional; Region: PRK00855
317655000534	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
317655000535	active sites [active]
317655000536	tetramer interface [polypeptide binding]; other site
317655000537	diaminopimelate decarboxylase; Region: lysA; TIGR01048
317655000538	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
317655000539	active site
317655000540	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655000541	substrate binding site [chemical binding]; other site
317655000542	catalytic residues [active]
317655000543	dimer interface [polypeptide binding]; other site
317655000544	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
317655000545	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
317655000546	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
317655000547	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
317655000548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000549	Walker A motif; other site
317655000550	ATP binding site [chemical binding]; other site
317655000551	Walker B motif; other site
317655000552	arginine finger; other site
317655000553	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655000554	phage shock protein A; Region: phageshock_pspA; TIGR02977
317655000555	Phage shock protein B; Region: PspB; pfam06667
317655000556	phage shock protein C; Region: phageshock_pspC; TIGR02978
317655000557	PspC domain; Region: PspC; pfam04024
317655000558	Fe-S metabolism associated domain; Region: SufE; cl00951
317655000559	hypothetical protein; Provisional; Region: PRK09133
317655000560	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
317655000561	putative metal binding site [ion binding]; other site
317655000562	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
317655000563	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
317655000564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
317655000565	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655000566	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655000567	acyl-activating enzyme (AAE) consensus motif; other site
317655000568	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655000569	acyl-activating enzyme (AAE) consensus motif; other site
317655000570	putative AMP binding site [chemical binding]; other site
317655000571	putative active site [active]
317655000572	putative CoA binding site [chemical binding]; other site
317655000573	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655000574	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
317655000575	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655000576	acyl-activating enzyme (AAE) consensus motif; other site
317655000577	acyl-activating enzyme (AAE) consensus motif; other site
317655000578	putative AMP binding site [chemical binding]; other site
317655000579	putative active site [active]
317655000580	putative CoA binding site [chemical binding]; other site
317655000581	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
317655000582	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
317655000583	putative catalytic residue [active]
317655000584	enoyl-CoA hydratase; Provisional; Region: PRK07509
317655000585	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655000586	substrate binding site [chemical binding]; other site
317655000587	oxyanion hole (OAH) forming residues; other site
317655000588	trimer interface [polypeptide binding]; other site
317655000589	Winged helix-turn helix; Region: HTH_29; pfam13551
317655000590	Integrase core domain; Region: rve; pfam00665
317655000591	Integrase core domain; Region: rve_3; pfam13683
317655000592	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655000593	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655000594	O-Antigen ligase; Region: Wzy_C; cl04850
317655000595	O-Antigen ligase; Region: Wzy_C; cl04850
317655000596	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
317655000597	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
317655000598	Predicted transcriptional regulator [Transcription]; Region: COG2932
317655000599	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
317655000600	Catalytic site [active]
317655000601	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
317655000602	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
317655000603	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
317655000604	dimer interface [polypeptide binding]; other site
317655000605	putative CheW interface [polypeptide binding]; other site
317655000606	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
317655000607	amphipathic channel; other site
317655000608	Asn-Pro-Ala signature motifs; other site
317655000609	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
317655000610	active site
317655000611	tetramer interface; other site
317655000612	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655000613	ligand binding site [chemical binding]; other site
317655000614	putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966
317655000615	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
317655000616	dimerization interface [polypeptide binding]; other site
317655000617	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655000618	metal binding site [ion binding]; metal-binding site
317655000619	active site
317655000620	I-site; other site
317655000621	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
317655000622	methionine sulfoxide reductase A; Provisional; Region: PRK14054
317655000623	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
317655000624	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
317655000625	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
317655000626	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
317655000627	23S rRNA interface [nucleotide binding]; other site
317655000628	L3 interface [polypeptide binding]; other site
317655000629	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
317655000630	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
317655000631	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655000632	NAD(P) binding site [chemical binding]; other site
317655000633	active site
317655000634	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
317655000635	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
317655000636	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
317655000637	dimerization interface 3.5A [polypeptide binding]; other site
317655000638	active site
317655000639	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
317655000640	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
317655000641	putative active site [active]
317655000642	substrate binding site [chemical binding]; other site
317655000643	putative cosubstrate binding site; other site
317655000644	catalytic site [active]
317655000645	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
317655000646	substrate binding site [chemical binding]; other site
317655000647	recombination protein RecR; Reviewed; Region: recR; PRK00076
317655000648	RecR protein; Region: RecR; pfam02132
317655000649	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
317655000650	putative active site [active]
317655000651	putative metal-binding site [ion binding]; other site
317655000652	tetramer interface [polypeptide binding]; other site
317655000653	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
317655000654	active site
317655000655	catalytic residues [active]
317655000656	metal binding site [ion binding]; metal-binding site
317655000657	GrpE; Region: GrpE; pfam01025
317655000658	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
317655000659	dimer interface [polypeptide binding]; other site
317655000660	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
317655000661	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
317655000662	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
317655000663	ribonuclease PH; Reviewed; Region: rph; PRK00173
317655000664	Ribonuclease PH; Region: RNase_PH_bact; cd11362
317655000665	hexamer interface [polypeptide binding]; other site
317655000666	active site
317655000667	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
317655000668	active site
317655000669	dimerization interface [polypeptide binding]; other site
317655000670	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
317655000671	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655000672	FeS/SAM binding site; other site
317655000673	HemN C-terminal domain; Region: HemN_C; pfam06969
317655000674	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
317655000675	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655000676	active site
317655000677	DNA binding site [nucleotide binding]
317655000678	Int/Topo IB signature motif; other site
317655000679	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
317655000680	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
317655000681	glutathione synthetase; Provisional; Region: PRK05246
317655000682	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
317655000683	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
317655000684	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
317655000685	Predicted methyltransferases [General function prediction only]; Region: COG0313
317655000686	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
317655000687	putative SAM binding site [chemical binding]; other site
317655000688	putative homodimer interface [polypeptide binding]; other site
317655000689	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
317655000690	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
317655000691	putative ligand binding site [chemical binding]; other site
317655000692	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
317655000693	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
317655000694	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
317655000695	NRDE protein; Region: NRDE; cl01315
317655000696	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
317655000697	Uncharacterized conserved protein [Function unknown]; Region: COG3586
317655000698	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000699	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000700	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
317655000701	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
317655000702	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
317655000703	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
317655000704	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
317655000705	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
317655000706	excinuclease ABC subunit B; Provisional; Region: PRK05298
317655000707	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655000708	ATP binding site [chemical binding]; other site
317655000709	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655000710	nucleotide binding region [chemical binding]; other site
317655000711	ATP-binding site [chemical binding]; other site
317655000712	Ultra-violet resistance protein B; Region: UvrB; pfam12344
317655000713	UvrB/uvrC motif; Region: UVR; pfam02151
317655000714	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
317655000715	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
317655000716	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655000717	acyl carrier protein; Provisional; Region: acpP; PRK00982
317655000718	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
317655000719	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
317655000720	dimer interface [polypeptide binding]; other site
317655000721	active site
317655000722	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655000723	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
317655000724	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
317655000725	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
317655000726	RNA polymerase sigma factor; Provisional; Region: PRK12547
317655000727	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655000728	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655000729	DNA binding residues [nucleotide binding]
317655000730	Sensors of blue-light using FAD; Region: BLUF; smart01034
317655000731	RNA polymerase sigma factor; Provisional; Region: PRK12547
317655000732	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655000733	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655000734	DNA binding residues [nucleotide binding]
317655000735	two-component response regulator; Provisional; Region: PRK09191
317655000736	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655000737	DNA binding residues [nucleotide binding]
317655000738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655000739	active site
317655000740	phosphorylation site [posttranslational modification]
317655000741	intermolecular recognition site; other site
317655000742	dimerization interface [polypeptide binding]; other site
317655000743	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
317655000744	GAF domain; Region: GAF; pfam01590
317655000745	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655000746	putative active site [active]
317655000747	heme pocket [chemical binding]; other site
317655000748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
317655000749	HWE histidine kinase; Region: HWE_HK; smart00911
317655000750	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
317655000751	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655000752	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
317655000753	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
317655000754	active site
317655000755	DNA binding site [nucleotide binding]
317655000756	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
317655000757	DNA binding site [nucleotide binding]
317655000758	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
317655000759	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
317655000760	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
317655000761	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
317655000762	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
317655000763	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
317655000764	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
317655000765	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
317655000766	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
317655000767	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655000768	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
317655000769	putative homodimer interface [polypeptide binding]; other site
317655000770	putative homotetramer interface [polypeptide binding]; other site
317655000771	putative metal binding site [ion binding]; other site
317655000772	putative homodimer-homodimer interface [polypeptide binding]; other site
317655000773	putative allosteric switch controlling residues; other site
317655000774	short chain dehydrogenase; Provisional; Region: PRK06949
317655000775	classical (c) SDRs; Region: SDR_c; cd05233
317655000776	NAD(P) binding site [chemical binding]; other site
317655000777	active site
317655000778	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655000779	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655000780	substrate binding site [chemical binding]; other site
317655000781	oxyanion hole (OAH) forming residues; other site
317655000782	trimer interface [polypeptide binding]; other site
317655000783	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
317655000784	Sulfatase; Region: Sulfatase; pfam00884
317655000785	Uncharacterized conserved protein [Function unknown]; Region: COG1262
317655000786	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
317655000787	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655000788	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655000789	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
317655000790	Sulfatase; Region: Sulfatase; pfam00884
317655000791	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655000792	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655000793	DNA binding site [nucleotide binding]
317655000794	domain linker motif; other site
317655000795	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
317655000796	putative dimerization interface [polypeptide binding]; other site
317655000797	putative ligand binding site [chemical binding]; other site
317655000798	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
317655000799	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
317655000800	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
317655000801	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
317655000802	beta-phosphoglucomutase; Region: bPGM; TIGR01990
317655000803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655000804	motif II; other site
317655000805	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
317655000806	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
317655000807	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655000808	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
317655000809	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
317655000810	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655000811	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
317655000812	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194
317655000813	putative active site [active]
317655000814	metal binding site [ion binding]; metal-binding site
317655000815	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655000816	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
317655000817	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655000818	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655000819	non-specific DNA binding site [nucleotide binding]; other site
317655000820	salt bridge; other site
317655000821	sequence-specific DNA binding site [nucleotide binding]; other site
317655000822	Autoinducer binding domain; Region: Autoind_bind; pfam03472
317655000823	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
317655000824	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655000825	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655000826	non-specific DNA binding site [nucleotide binding]; other site
317655000827	salt bridge; other site
317655000828	sequence-specific DNA binding site [nucleotide binding]; other site
317655000829	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655000830	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655000831	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
317655000832	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
317655000833	type II secretion system protein D; Region: type_II_gspD; TIGR02517
317655000834	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
317655000835	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
317655000836	type II secretion system protein E; Region: type_II_gspE; TIGR02533
317655000837	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
317655000838	Walker A motif; other site
317655000839	ATP binding site [chemical binding]; other site
317655000840	Walker B motif; other site
317655000841	type II secretion system protein F; Region: GspF; TIGR02120
317655000842	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655000843	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655000844	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
317655000845	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
317655000846	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
317655000847	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
317655000848	type II secretion system protein I; Region: gspI; TIGR01707
317655000849	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
317655000850	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
317655000851	type II secretion system protein J; Region: gspJ; TIGR01711
317655000852	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
317655000853	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
317655000854	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
317655000855	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
317655000856	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
317655000857	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
317655000858	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
317655000859	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655000860	ligand binding site [chemical binding]; other site
317655000861	translocation protein TolB; Provisional; Region: tolB; PRK05137
317655000862	TolB amino-terminal domain; Region: TolB_N; pfam04052
317655000863	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655000864	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655000865	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655000866	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
317655000867	TolR protein; Region: tolR; TIGR02801
317655000868	TolQ protein; Region: tolQ; TIGR02796
317655000869	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655000870	active site
317655000871	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
317655000872	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655000873	Walker A motif; other site
317655000874	ATP binding site [chemical binding]; other site
317655000875	Walker B motif; other site
317655000876	arginine finger; other site
317655000877	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
317655000878	Uncharacterized conserved protein [Function unknown]; Region: COG3791
317655000879	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
317655000880	RuvA N terminal domain; Region: RuvA_N; pfam01330
317655000881	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
317655000882	active site
317655000883	putative DNA-binding cleft [nucleotide binding]; other site
317655000884	dimer interface [polypeptide binding]; other site
317655000885	hypothetical protein; Validated; Region: PRK00110
317655000886	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
317655000887	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
317655000888	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
317655000889	pyruvate kinase; Provisional; Region: PRK06247
317655000890	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
317655000891	domain interfaces; other site
317655000892	active site
317655000893	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
317655000894	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
317655000895	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
317655000896	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655000897	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655000898	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655000899	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655000900	ligand binding site [chemical binding]; other site
317655000901	flexible hinge region; other site
317655000902	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655000903	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655000904	ligand binding site [chemical binding]; other site
317655000905	flexible hinge region; other site
317655000906	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
317655000907	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
317655000908	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
317655000909	4Fe-4S binding domain; Region: Fer4_6; pfam12837
317655000910	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
317655000911	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
317655000912	active site
317655000913	metal binding site [ion binding]; metal-binding site
317655000914	hexamer interface [polypeptide binding]; other site
317655000915	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
317655000916	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
317655000917	NAD binding site [chemical binding]; other site
317655000918	ligand binding site [chemical binding]; other site
317655000919	catalytic site [active]
317655000920	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
317655000921	putative active site [active]
317655000922	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
317655000923	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655000924	active site
317655000925	HIGH motif; other site
317655000926	nucleotide binding site [chemical binding]; other site
317655000927	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655000928	active site
317655000929	KMSKS motif; other site
317655000930	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
317655000931	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
317655000932	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
317655000933	Surface antigen; Region: Bac_surface_Ag; pfam01103
317655000934	CHASE2 domain; Region: CHASE2; pfam05226
317655000935	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
317655000936	cyclase homology domain; Region: CHD; cd07302
317655000937	nucleotidyl binding site; other site
317655000938	metal binding site [ion binding]; metal-binding site
317655000939	dimer interface [polypeptide binding]; other site
317655000940	CHAT domain; Region: CHAT; pfam12770
317655000941	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
317655000942	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
317655000943	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
317655000944	putative GSH binding site [chemical binding]; other site
317655000945	catalytic residues [active]
317655000946	Penicillinase repressor; Region: Pencillinase_R; pfam03965
317655000947	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
317655000948	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655000949	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
317655000950	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
317655000951	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
317655000952	NAD(P) binding site [chemical binding]; other site
317655000953	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655000954	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
317655000955	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655000956	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
317655000957	dimerization interface [polypeptide binding]; other site
317655000958	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
317655000959	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
317655000960	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
317655000961	Protein of unknown function, DUF481; Region: DUF481; pfam04338
317655000962	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
317655000963	putative dimer interface [polypeptide binding]; other site
317655000964	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655000965	ligand binding site [chemical binding]; other site
317655000966	Zn binding site [ion binding]; other site
317655000967	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
317655000968	hypothetical protein; Provisional; Region: PRK06446
317655000969	metal binding site [ion binding]; metal-binding site
317655000970	dimer interface [polypeptide binding]; other site
317655000971	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
317655000972	classical (c) SDRs; Region: SDR_c; cd05233
317655000973	NAD(P) binding site [chemical binding]; other site
317655000974	active site
317655000975	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
317655000976	Fumarase C-terminus; Region: Fumerase_C; pfam05683
317655000977	MerC mercury resistance protein; Region: MerC; pfam03203
317655000978	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
317655000979	metal binding site 2 [ion binding]; metal-binding site
317655000980	putative DNA binding helix; other site
317655000981	metal binding site 1 [ion binding]; metal-binding site
317655000982	dimer interface [polypeptide binding]; other site
317655000983	structural Zn2+ binding site [ion binding]; other site
317655000984	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
317655000985	active site
317655000986	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
317655000987	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
317655000988	Trp docking motif [polypeptide binding]; other site
317655000989	cytochrome domain interface [polypeptide binding]; other site
317655000990	active site
317655000991	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
317655000992	LabA_like proteins; Region: LabA_like/DUF88; cl10034
317655000993	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
317655000994	Integrase core domain; Region: rve; pfam00665
317655000995	Integrase core domain; Region: rve_3; pfam13683
317655000996	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
317655000997	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
317655000998	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
317655000999	protein binding site [polypeptide binding]; other site
317655001000	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655001001	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
317655001002	putative dimer interface [polypeptide binding]; other site
317655001003	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655001004	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
317655001005	putative dimer interface [polypeptide binding]; other site
317655001006	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
317655001007	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
317655001008	Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157
317655001009	putative active site [active]
317655001010	catalytic site [active]
317655001011	Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163
317655001012	putative active site [active]
317655001013	catalytic site [active]
317655001014	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
317655001015	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
317655001016	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655001017	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
317655001018	putative dimer interface [polypeptide binding]; other site
317655001019	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655001020	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
317655001021	putative dimer interface [polypeptide binding]; other site
317655001022	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655001023	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
317655001024	putative dimer interface [polypeptide binding]; other site
317655001025	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655001026	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655001027	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
317655001028	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
317655001029	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
317655001030	dimerization interface [polypeptide binding]; other site
317655001031	DPS ferroxidase diiron center [ion binding]; other site
317655001032	ion pore; other site
317655001033	Transposase domain (DUF772); Region: DUF772; pfam05598
317655001034	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
317655001035	Transposase; Region: DEDD_Tnp_IS110; pfam01548
317655001036	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
317655001037	Transposase; Region: HTH_Tnp_1; pfam01527
317655001038	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
317655001039	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
317655001040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
317655001041	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
317655001042	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
317655001043	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
317655001044	GrpE; Region: GrpE; pfam01025
317655001045	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
317655001046	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
317655001047	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
317655001048	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
317655001049	nucleotide binding site [chemical binding]; other site
317655001050	NEF interaction site [polypeptide binding]; other site
317655001051	SBD interface [polypeptide binding]; other site
317655001052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655001053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655001054	ATP binding site [chemical binding]; other site
317655001055	G-X-G motif; other site
317655001056	chaperone protein DnaJ; Provisional; Region: PRK14299
317655001057	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
317655001058	HSP70 interaction site [polypeptide binding]; other site
317655001059	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
317655001060	substrate binding site [polypeptide binding]; other site
317655001061	dimer interface [polypeptide binding]; other site
317655001062	thioredoxin 2; Provisional; Region: PRK10996
317655001063	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
317655001064	catalytic residues [active]
317655001065	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
317655001066	Clp amino terminal domain; Region: Clp_N; pfam02861
317655001067	Clp amino terminal domain; Region: Clp_N; pfam02861
317655001068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655001069	Walker A motif; other site
317655001070	ATP binding site [chemical binding]; other site
317655001071	Walker B motif; other site
317655001072	arginine finger; other site
317655001073	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655001074	Walker A motif; other site
317655001075	ATP binding site [chemical binding]; other site
317655001076	Walker B motif; other site
317655001077	arginine finger; other site
317655001078	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
317655001079	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655001080	YfdX protein; Region: YfdX; pfam10938
317655001081	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
317655001082	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
317655001083	Phosphate-starvation-inducible E; Region: PsiE; pfam06146
317655001084	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
317655001085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
317655001086	Transposase; Region: HTH_Tnp_1; pfam01527
317655001087	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
317655001088	Integrase core domain; Region: rve; pfam00665
317655001089	transposase/IS protein; Provisional; Region: PRK09183
317655001090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655001091	Walker A motif; other site
317655001092	ATP binding site [chemical binding]; other site
317655001093	Walker B motif; other site
317655001094	arginine finger; other site
317655001095	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
317655001096	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
317655001097	dimer interface [polypeptide binding]; other site
317655001098	ssDNA binding site [nucleotide binding]; other site
317655001099	tetramer (dimer of dimers) interface [polypeptide binding]; other site
317655001100	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
317655001101	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
317655001102	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
317655001103	ParB-like nuclease domain; Region: ParBc; pfam02195
317655001104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655001105	Walker A/P-loop; other site
317655001106	ATP binding site [chemical binding]; other site
317655001107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655001108	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
317655001109	Walker A motif; other site
317655001110	ATP binding site [chemical binding]; other site
317655001111	Walker B motif; other site
317655001112	arginine finger; other site
317655001113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
317655001114	Integrase core domain; Region: rve; pfam00665
317655001115	RES domain; Region: RES; smart00953
317655001116	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
317655001117	Helicase_C-like; Region: Helicase_C_4; pfam13871
317655001118	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
317655001119	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655001120	active site
317655001121	DNA binding site [nucleotide binding]
317655001122	Int/Topo IB signature motif; other site
317655001123	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655001124	active site
317655001125	DNA binding site [nucleotide binding]
317655001126	Int/Topo IB signature motif; other site
317655001127	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
317655001128	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
317655001129	Int/Topo IB signature motif; other site
317655001130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655001131	S-adenosylmethionine binding site [chemical binding]; other site
317655001132	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
317655001133	CHC2 zinc finger; Region: zf-CHC2; cl17510
317655001134	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
317655001135	active site
317655001136	metal binding site [ion binding]; metal-binding site
317655001137	interdomain interaction site; other site
317655001138	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
317655001139	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655001140	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655001141	catalytic residue [active]
317655001142	integrase; Provisional; Region: PRK09692
317655001143	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
317655001144	active site
317655001145	Int/Topo IB signature motif; other site
317655001146	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
317655001147	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655001148	Galactose oxidase, central domain; Region: Kelch_3; cl02701
317655001149	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
317655001150	Galactose oxidase, central domain; Region: Kelch_3; pfam13415
317655001151	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
317655001152	Galactose oxidase, central domain; Region: Kelch_3; cl02701
317655001153	YceG-like family; Region: YceG; pfam02618
317655001154	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
317655001155	dimerization interface [polypeptide binding]; other site
317655001156	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655001157	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655001158	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
317655001159	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
317655001160	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
317655001161	ring oligomerisation interface [polypeptide binding]; other site
317655001162	ATP/Mg binding site [chemical binding]; other site
317655001163	stacking interactions; other site
317655001164	hinge regions; other site
317655001165	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
317655001166	oligomerisation interface [polypeptide binding]; other site
317655001167	mobile loop; other site
317655001168	roof hairpin; other site
317655001169	multidrug efflux protein; Reviewed; Region: PRK01766
317655001170	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
317655001171	cation binding site [ion binding]; other site
317655001172	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655001173	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655001174	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
317655001175	active site
317655001176	Zn binding site [ion binding]; other site
317655001177	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655001178	putative DNA binding site [nucleotide binding]; other site
317655001179	putative Zn2+ binding site [ion binding]; other site
317655001180	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
317655001181	putative hydrophobic ligand binding site [chemical binding]; other site
317655001182	tRNA_anti-like; Region: tRNA_anti-like; pfam12869
317655001183	Domain of unknown function DUF87; Region: DUF87; pfam01935
317655001184	HerA helicase [Replication, recombination, and repair]; Region: COG0433
317655001185	PilZ domain; Region: PilZ; pfam07238
317655001186	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
317655001187	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655001188	active site
317655001189	nucleotide binding site [chemical binding]; other site
317655001190	HIGH motif; other site
317655001191	KMSKS motif; other site
317655001192	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
317655001193	active site
317655001194	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
317655001195	Fatty acid desaturase; Region: FA_desaturase; pfam00487
317655001196	putative di-iron ligands [ion binding]; other site
317655001197	This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510
317655001198	PAS domain; Region: PAS_9; pfam13426
317655001199	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655001200	putative active site [active]
317655001201	heme pocket [chemical binding]; other site
317655001202	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655001203	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655001204	metal binding site [ion binding]; metal-binding site
317655001205	active site
317655001206	I-site; other site
317655001207	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655001208	PilZ domain; Region: PilZ; pfam07238
317655001209	quinolinate synthetase; Provisional; Region: PRK09375
317655001210	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
317655001211	Predicted membrane protein [Function unknown]; Region: COG2261
317655001212	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
317655001213	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655001214	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
317655001215	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
317655001216	Protein of unknown function (DUF445); Region: DUF445; pfam04286
317655001217	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
317655001218	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655001219	putative NAD(P) binding site [chemical binding]; other site
317655001220	aminopeptidase N; Provisional; Region: pepN; PRK14015
317655001221	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
317655001222	active site
317655001223	Zn binding site [ion binding]; other site
317655001224	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
317655001225	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655001226	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655001227	Protein of unknown function (DUF330); Region: DUF330; cl01135
317655001228	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
317655001229	mce related protein; Region: MCE; pfam02470
317655001230	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
317655001231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655001232	Walker A/P-loop; other site
317655001233	ATP binding site [chemical binding]; other site
317655001234	Q-loop/lid; other site
317655001235	ABC transporter signature motif; other site
317655001236	Walker B; other site
317655001237	D-loop; other site
317655001238	H-loop/switch region; other site
317655001239	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
317655001240	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
317655001241	Permease; Region: Permease; pfam02405
317655001242	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
317655001243	methionine gamma-lyase; Validated; Region: PRK07049
317655001244	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
317655001245	homodimer interface [polypeptide binding]; other site
317655001246	substrate-cofactor binding pocket; other site
317655001247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655001248	catalytic residue [active]
317655001249	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
317655001250	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
317655001251	transmembrane helices; other site
317655001252	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
317655001253	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
317655001254	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655001255	Uncharacterized conserved protein [Function unknown]; Region: COG1565
317655001256	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
317655001257	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655001258	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655001259	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
317655001260	acyl-activating enzyme (AAE) consensus motif; other site
317655001261	acyl-activating enzyme (AAE) consensus motif; other site
317655001262	putative AMP binding site [chemical binding]; other site
317655001263	putative active site [active]
317655001264	putative CoA binding site [chemical binding]; other site
317655001265	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
317655001266	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
317655001267	Moco binding site; other site
317655001268	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
317655001269	metal coordination site [ion binding]; other site
317655001270	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
317655001271	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655001272	S-adenosylmethionine binding site [chemical binding]; other site
317655001273	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
317655001274	Peptidase S46; Region: Peptidase_S46; pfam10459
317655001275	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
317655001276	argininosuccinate synthase; Provisional; Region: PRK13820
317655001277	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
317655001278	ANP binding site [chemical binding]; other site
317655001279	Substrate Binding Site II [chemical binding]; other site
317655001280	Substrate Binding Site I [chemical binding]; other site
317655001281	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
317655001282	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
317655001283	tetramer interface [polypeptide binding]; other site
317655001284	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655001285	catalytic residue [active]
317655001286	EamA-like transporter family; Region: EamA; pfam00892
317655001287	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655001288	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
317655001289	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
317655001290	hinge; other site
317655001291	active site
317655001292	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
317655001293	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
317655001294	putative catalytic residue [active]
317655001295	classical (c) SDR, subgroup  10; Region: SDR_c10; cd05373
317655001296	putative NAD(P) binding site [chemical binding]; other site
317655001297	active site
317655001298	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655001299	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655001300	dimerization interface [polypeptide binding]; other site
317655001301	putative DNA binding site [nucleotide binding]; other site
317655001302	putative Zn2+ binding site [ion binding]; other site
317655001303	Uncharacterized conserved protein [Function unknown]; Region: COG2127
317655001304	Phasin protein; Region: Phasin_2; pfam09361
317655001305	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
317655001306	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
317655001307	aminotransferase; Validated; Region: PRK09148
317655001308	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
317655001309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655001310	homodimer interface [polypeptide binding]; other site
317655001311	catalytic residue [active]
317655001312	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
317655001313	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655001314	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655001315	putative substrate translocation pore; other site
317655001316	Predicted flavoprotein [General function prediction only]; Region: COG0431
317655001317	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655001318	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
317655001319	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
317655001320	GDP-binding site [chemical binding]; other site
317655001321	ACT binding site; other site
317655001322	IMP binding site; other site
317655001323	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
317655001324	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
317655001325	nucleophilic elbow; other site
317655001326	catalytic triad; other site
317655001327	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655001328	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
317655001329	C-terminal domain interface [polypeptide binding]; other site
317655001330	GSH binding site (G-site) [chemical binding]; other site
317655001331	dimer interface [polypeptide binding]; other site
317655001332	C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178
317655001333	dimer interface [polypeptide binding]; other site
317655001334	N-terminal domain interface [polypeptide binding]; other site
317655001335	chorismate mutase; Provisional; Region: PRK09239
317655001336	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
317655001337	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
317655001338	substrate binding pocket [chemical binding]; other site
317655001339	chain length determination region; other site
317655001340	substrate-Mg2+ binding site; other site
317655001341	catalytic residues [active]
317655001342	aspartate-rich region 1; other site
317655001343	active site lid residues [active]
317655001344	aspartate-rich region 2; other site
317655001345	Domain of unknown function (DU1801); Region: DUF1801; cl17490
317655001346	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
317655001347	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655001348	ATP binding site [chemical binding]; other site
317655001349	putative Mg++ binding site [ion binding]; other site
317655001350	helicase superfamily c-terminal domain; Region: HELICc; smart00490
317655001351	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
317655001352	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
317655001353	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
317655001354	enolase; Provisional; Region: eno; PRK00077
317655001355	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
317655001356	dimer interface [polypeptide binding]; other site
317655001357	metal binding site [ion binding]; metal-binding site
317655001358	substrate binding pocket [chemical binding]; other site
317655001359	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
317655001360	Septum formation initiator; Region: DivIC; pfam04977
317655001361	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
317655001362	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
317655001363	tetramer interface [polypeptide binding]; other site
317655001364	TPP-binding site [chemical binding]; other site
317655001365	heterodimer interface [polypeptide binding]; other site
317655001366	phosphorylation loop region [posttranslational modification]
317655001367	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
317655001368	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
317655001369	E3 interaction surface; other site
317655001370	lipoyl attachment site [posttranslational modification]; other site
317655001371	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
317655001372	alpha subunit interface [polypeptide binding]; other site
317655001373	TPP binding site [chemical binding]; other site
317655001374	heterodimer interface [polypeptide binding]; other site
317655001375	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
317655001376	serine O-acetyltransferase; Region: cysE; TIGR01172
317655001377	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
317655001378	trimer interface [polypeptide binding]; other site
317655001379	active site
317655001380	substrate binding site [chemical binding]; other site
317655001381	CoA binding site [chemical binding]; other site
317655001382	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
317655001383	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
317655001384	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
317655001385	NAD binding site [chemical binding]; other site
317655001386	homodimer interface [polypeptide binding]; other site
317655001387	active site
317655001388	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
317655001389	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
317655001390	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
317655001391	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
317655001392	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
317655001393	heme-binding site [chemical binding]; other site
317655001394	Transcriptional regulator; Region: Rrf2; cl17282
317655001395	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
317655001396	AbgT putative transporter family; Region: ABG_transport; cl17431
317655001397	thymidine kinase; Provisional; Region: PRK04296
317655001398	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
317655001399	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655001400	Coenzyme A binding pocket [chemical binding]; other site
317655001401	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
317655001402	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
317655001403	RNA binding site [nucleotide binding]; other site
317655001404	active site
317655001405	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
317655001406	16S/18S rRNA binding site [nucleotide binding]; other site
317655001407	S13e-L30e interaction site [polypeptide binding]; other site
317655001408	25S rRNA binding site [nucleotide binding]; other site
317655001409	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
317655001410	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
317655001411	RNase E interface [polypeptide binding]; other site
317655001412	trimer interface [polypeptide binding]; other site
317655001413	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
317655001414	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
317655001415	RNase E interface [polypeptide binding]; other site
317655001416	trimer interface [polypeptide binding]; other site
317655001417	active site
317655001418	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
317655001419	putative nucleic acid binding region [nucleotide binding]; other site
317655001420	G-X-X-G motif; other site
317655001421	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
317655001422	RNA binding site [nucleotide binding]; other site
317655001423	domain interface; other site
317655001424	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
317655001425	active site
317655001426	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
317655001427	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
317655001428	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
317655001429	Walker A/P-loop; other site
317655001430	ATP binding site [chemical binding]; other site
317655001431	Q-loop/lid; other site
317655001432	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
317655001433	ABC transporter signature motif; other site
317655001434	Walker B; other site
317655001435	D-loop; other site
317655001436	H-loop/switch region; other site
317655001437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655001438	Coenzyme A binding pocket [chemical binding]; other site
317655001439	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
317655001440	putative active site [active]
317655001441	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
317655001442	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
317655001443	nucleotide binding pocket [chemical binding]; other site
317655001444	K-X-D-G motif; other site
317655001445	catalytic site [active]
317655001446	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
317655001447	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
317655001448	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
317655001449	Dimer interface [polypeptide binding]; other site
317655001450	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
317655001451	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
317655001452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655001453	dimer interface [polypeptide binding]; other site
317655001454	conserved gate region; other site
317655001455	putative PBP binding loops; other site
317655001456	ABC-ATPase subunit interface; other site
317655001457	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655001458	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
317655001459	Walker A/P-loop; other site
317655001460	ATP binding site [chemical binding]; other site
317655001461	Q-loop/lid; other site
317655001462	ABC transporter signature motif; other site
317655001463	Walker B; other site
317655001464	D-loop; other site
317655001465	H-loop/switch region; other site
317655001466	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
317655001467	cofactor binding site; other site
317655001468	metal binding site [ion binding]; metal-binding site
317655001469	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
317655001470	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655001471	S-adenosylmethionine binding site [chemical binding]; other site
317655001472	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
317655001473	classical (c) SDRs; Region: SDR_c; cd05233
317655001474	NAD(P) binding site [chemical binding]; other site
317655001475	active site
317655001476	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
317655001477	dimer interface [polypeptide binding]; other site
317655001478	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
317655001479	putative CheW interface [polypeptide binding]; other site
317655001480	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655001481	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655001482	putative DNA binding site [nucleotide binding]; other site
317655001483	putative Zn2+ binding site [ion binding]; other site
317655001484	AsnC family; Region: AsnC_trans_reg; pfam01037
317655001485	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
317655001486	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
317655001487	hexamer interface [polypeptide binding]; other site
317655001488	ligand binding site [chemical binding]; other site
317655001489	putative active site [active]
317655001490	NAD(P) binding site [chemical binding]; other site
317655001491	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655001492	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655001493	Pirin-related protein [General function prediction only]; Region: COG1741
317655001494	Pirin; Region: Pirin; pfam02678
317655001495	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
317655001496	putative effector binding pocket; other site
317655001497	dimerization interface [polypeptide binding]; other site
317655001498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
317655001499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655001500	active site
317655001501	phosphorylation site [posttranslational modification]
317655001502	intermolecular recognition site; other site
317655001503	dimerization interface [polypeptide binding]; other site
317655001504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
317655001505	DNA binding site [nucleotide binding]
317655001506	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
317655001507	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
317655001508	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
317655001509	alphaNTD - beta interaction site [polypeptide binding]; other site
317655001510	alphaNTD homodimer interface [polypeptide binding]; other site
317655001511	alphaNTD - beta' interaction site [polypeptide binding]; other site
317655001512	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
317655001513	30S ribosomal protein S11; Validated; Region: PRK05309
317655001514	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
317655001515	30S ribosomal protein S13; Region: bact_S13; TIGR03631
317655001516	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
317655001517	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
317655001518	active site
317655001519	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
317655001520	Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042
317655001521	diiron binding motif [ion binding]; other site
317655001522	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
317655001523	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
317655001524	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
317655001525	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
317655001526	protein binding site [polypeptide binding]; other site
317655001527	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
317655001528	Catalytic dyad [active]
317655001529	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655001530	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
317655001531	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
317655001532	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
317655001533	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
317655001534	active site
317655001535	(T/H)XGH motif; other site
317655001536	Predicted transcriptional regulator [Transcription]; Region: COG3905
317655001537	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
317655001538	putative catalytic cysteine [active]
317655001539	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
317655001540	enoyl-CoA hydratase; Provisional; Region: PRK08260
317655001541	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655001542	substrate binding site [chemical binding]; other site
317655001543	oxyanion hole (OAH) forming residues; other site
317655001544	trimer interface [polypeptide binding]; other site
317655001545	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
317655001546	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
317655001547	ATP binding site [chemical binding]; other site
317655001548	active site
317655001549	substrate binding site [chemical binding]; other site
317655001550	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655001551	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
317655001552	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655001553	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655001554	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655001555	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
317655001556	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
317655001557	heme binding site [chemical binding]; other site
317655001558	ferroxidase pore; other site
317655001559	ferroxidase diiron center [ion binding]; other site
317655001560	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
317655001561	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
317655001562	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
317655001563	putative active site [active]
317655001564	catalytic triad [active]
317655001565	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
317655001566	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
317655001567	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
317655001568	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655001569	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655001570	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
317655001571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655001572	putative substrate translocation pore; other site
317655001573	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655001574	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655001575	DNA binding site [nucleotide binding]
317655001576	domain linker motif; other site
317655001577	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
317655001578	putative dimerization interface [polypeptide binding]; other site
317655001579	putative ligand binding site [chemical binding]; other site
317655001580	Predicted methyltransferase [General function prediction only]; Region: COG4798
317655001581	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
317655001582	bacteriophage N4 adsorption protein B; Provisional; Region: PRK14716
317655001583	active site
317655001584	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
317655001585	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
317655001586	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
317655001587	Domain of unknown function DUF87; Region: DUF87; pfam01935
317655001588	AAA-like domain; Region: AAA_10; pfam12846
317655001589	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
317655001590	active site
317655001591	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
317655001592	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
317655001593	hypothetical protein; Provisional; Region: PRK14636
317655001594	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
317655001595	putative oligomer interface [polypeptide binding]; other site
317655001596	putative RNA binding site [nucleotide binding]; other site
317655001597	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
317655001598	NusA N-terminal domain; Region: NusA_N; pfam08529
317655001599	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
317655001600	RNA binding site [nucleotide binding]; other site
317655001601	homodimer interface [polypeptide binding]; other site
317655001602	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
317655001603	G-X-X-G motif; other site
317655001604	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
317655001605	G-X-X-G motif; other site
317655001606	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
317655001607	Protein of unknown function (DUF448); Region: DUF448; pfam04296
317655001608	putative RNA binding cleft [nucleotide binding]; other site
317655001609	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
317655001610	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
317655001611	translation initiation factor IF-2; Region: IF-2; TIGR00487
317655001612	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
317655001613	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
317655001614	G1 box; other site
317655001615	putative GEF interaction site [polypeptide binding]; other site
317655001616	GTP/Mg2+ binding site [chemical binding]; other site
317655001617	Switch I region; other site
317655001618	G2 box; other site
317655001619	G3 box; other site
317655001620	Switch II region; other site
317655001621	G4 box; other site
317655001622	G5 box; other site
317655001623	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
317655001624	Translation-initiation factor 2; Region: IF-2; pfam11987
317655001625	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
317655001626	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
317655001627	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
317655001628	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
317655001629	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
317655001630	motif 1; other site
317655001631	dimer interface [polypeptide binding]; other site
317655001632	active site
317655001633	motif 2; other site
317655001634	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
317655001635	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
317655001636	ligand binding site [chemical binding]; other site
317655001637	NAD binding site [chemical binding]; other site
317655001638	dimerization interface [polypeptide binding]; other site
317655001639	catalytic site [active]
317655001640	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
317655001641	putative L-serine binding site [chemical binding]; other site
317655001642	phosphoserine aminotransferase; Provisional; Region: PRK03080
317655001643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655001644	catalytic residue [active]
317655001645	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
317655001646	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
317655001647	Cytochrome c2 [Energy production and conversion]; Region: COG3474
317655001648	Cytochrome c2 [Energy production and conversion]; Region: COG3474
317655001649	prephenate dehydratase; Provisional; Region: PRK11899
317655001650	Prephenate dehydratase; Region: PDT; pfam00800
317655001651	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
317655001652	putative L-Phe binding site [chemical binding]; other site
317655001653	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
317655001654	DNA polymerase I; Provisional; Region: PRK05755
317655001655	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
317655001656	active site
317655001657	metal binding site 1 [ion binding]; metal-binding site
317655001658	putative 5' ssDNA interaction site; other site
317655001659	metal binding site 3; metal-binding site
317655001660	metal binding site 2 [ion binding]; metal-binding site
317655001661	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
317655001662	putative DNA binding site [nucleotide binding]; other site
317655001663	putative metal binding site [ion binding]; other site
317655001664	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
317655001665	active site
317655001666	substrate binding site [chemical binding]; other site
317655001667	catalytic site [active]
317655001668	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
317655001669	active site
317655001670	DNA binding site [nucleotide binding]
317655001671	catalytic site [active]
317655001672	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
317655001673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655001674	Coenzyme A binding pocket [chemical binding]; other site
317655001675	peroxiredoxin; Region: AhpC; TIGR03137
317655001676	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
317655001677	dimer interface [polypeptide binding]; other site
317655001678	decamer (pentamer of dimers) interface [polypeptide binding]; other site
317655001679	catalytic triad [active]
317655001680	peroxidatic and resolving cysteines [active]
317655001681	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
317655001682	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
317655001683	catalytic residue [active]
317655001684	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
317655001685	catalytic residues [active]
317655001686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655001687	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655001688	Uncharacterized conserved protein [Function unknown]; Region: COG3791
317655001689	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655001690	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
317655001691	C-terminal domain interface [polypeptide binding]; other site
317655001692	GSH binding site (G-site) [chemical binding]; other site
317655001693	dimer interface [polypeptide binding]; other site
317655001694	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
317655001695	dimer interface [polypeptide binding]; other site
317655001696	N-terminal domain interface [polypeptide binding]; other site
317655001697	substrate binding pocket (H-site) [chemical binding]; other site
317655001698	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655001699	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
317655001700	GMP synthase; Reviewed; Region: guaA; PRK00074
317655001701	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
317655001702	AMP/PPi binding site [chemical binding]; other site
317655001703	candidate oxyanion hole; other site
317655001704	catalytic triad [active]
317655001705	potential glutamine specificity residues [chemical binding]; other site
317655001706	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
317655001707	ATP Binding subdomain [chemical binding]; other site
317655001708	Ligand Binding sites [chemical binding]; other site
317655001709	Dimerization subdomain; other site
317655001710	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655001711	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
317655001712	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
317655001713	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
317655001714	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
317655001715	putative active site [active]
317655001716	putative metal binding site [ion binding]; other site
317655001717	Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147
317655001718	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655001719	NAD(P) binding site [chemical binding]; other site
317655001720	catalytic residues [active]
317655001721	acetolactate synthase; Reviewed; Region: PRK08322
317655001722	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
317655001723	PYR/PP interface [polypeptide binding]; other site
317655001724	dimer interface [polypeptide binding]; other site
317655001725	TPP binding site [chemical binding]; other site
317655001726	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
317655001727	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
317655001728	TPP-binding site [chemical binding]; other site
317655001729	dimer interface [polypeptide binding]; other site
317655001730	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
317655001731	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
317655001732	metal ion-dependent adhesion site (MIDAS); other site
317655001733	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
317655001734	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
317655001735	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
317655001736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
317655001737	SnoaL-like domain; Region: SnoaL_2; pfam12680
317655001738	DnaJ domain; Region: DnaJ; pfam00226
317655001739	HSP70 interaction site [polypeptide binding]; other site
317655001740	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
317655001741	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
317655001742	Pirin-related protein [General function prediction only]; Region: COG1741
317655001743	Pirin; Region: Pirin; pfam02678
317655001744	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
317655001745	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655001746	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655001747	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655001748	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
317655001749	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
317655001750	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
317655001751	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
317655001752	chaperone protein DnaJ; Provisional; Region: PRK14299
317655001753	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
317655001754	HSP70 interaction site [polypeptide binding]; other site
317655001755	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
317655001756	substrate binding site [polypeptide binding]; other site
317655001757	dimer interface [polypeptide binding]; other site
317655001758	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
317655001759	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
317655001760	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
317655001761	NAD binding site [chemical binding]; other site
317655001762	homotetramer interface [polypeptide binding]; other site
317655001763	homodimer interface [polypeptide binding]; other site
317655001764	substrate binding site [chemical binding]; other site
317655001765	active site
317655001766	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655001767	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
317655001768	dimer interface [polypeptide binding]; other site
317655001769	putative metal binding site [ion binding]; other site
317655001770	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
317655001771	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
317655001772	Tetramer interface [polypeptide binding]; other site
317655001773	active site
317655001774	FMN-binding site [chemical binding]; other site
317655001775	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
317655001776	transmembrane helices; other site
317655001777	TrkA-C domain; Region: TrkA_C; pfam02080
317655001778	TrkA-C domain; Region: TrkA_C; pfam02080
317655001779	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
317655001780	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
317655001781	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
317655001782	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
317655001783	Cytochrome P450; Region: p450; cl12078
317655001784	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655001785	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
317655001786	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655001787	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
317655001788	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
317655001789	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
317655001790	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
317655001791	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655001792	catalytic residue [active]
317655001793	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
317655001794	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
317655001795	FeS assembly ATPase SufC; Region: sufC; TIGR01978
317655001796	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
317655001797	Walker A/P-loop; other site
317655001798	ATP binding site [chemical binding]; other site
317655001799	Q-loop/lid; other site
317655001800	ABC transporter signature motif; other site
317655001801	Walker B; other site
317655001802	D-loop; other site
317655001803	H-loop/switch region; other site
317655001804	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655001805	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
317655001806	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
317655001807	putative active site [active]
317655001808	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
317655001809	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
317655001810	putative ABC transporter; Region: ycf24; CHL00085
317655001811	Transcriptional regulator; Region: Rrf2; cl17282
317655001812	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
317655001813	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655001814	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655001815	Helix-turn-helix domain; Region: HTH_18; pfam12833
317655001816	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
317655001817	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
317655001818	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
317655001819	quinone interaction residues [chemical binding]; other site
317655001820	active site
317655001821	catalytic residues [active]
317655001822	FMN binding site [chemical binding]; other site
317655001823	substrate binding site [chemical binding]; other site
317655001824	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
317655001825	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
317655001826	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
317655001827	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
317655001828	acyl-activating enzyme (AAE) consensus motif; other site
317655001829	putative AMP binding site [chemical binding]; other site
317655001830	putative active site [active]
317655001831	putative CoA binding site [chemical binding]; other site
317655001832	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
317655001833	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655001834	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
317655001835	dimer interface [polypeptide binding]; other site
317655001836	active site
317655001837	metal binding site [ion binding]; metal-binding site
317655001838	glutathione binding site [chemical binding]; other site
317655001839	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655001840	active site
317655001841	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655001842	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655001843	non-specific DNA binding site [nucleotide binding]; other site
317655001844	salt bridge; other site
317655001845	sequence-specific DNA binding site [nucleotide binding]; other site
317655001846	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
317655001847	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
317655001848	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
317655001849	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
317655001850	active site
317655001851	dimer interface [polypeptide binding]; other site
317655001852	motif 1; other site
317655001853	motif 2; other site
317655001854	motif 3; other site
317655001855	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
317655001856	anticodon binding site; other site
317655001857	Helix-turn-helix domain; Region: HTH_18; pfam12833
317655001858	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
317655001859	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
317655001860	Large family of predicted nucleotide-binding domains; Region: PINc; smart00670
317655001861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
317655001862	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
317655001863	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
317655001864	Walker A/P-loop; other site
317655001865	ATP binding site [chemical binding]; other site
317655001866	Q-loop/lid; other site
317655001867	ABC transporter signature motif; other site
317655001868	Walker B; other site
317655001869	D-loop; other site
317655001870	H-loop/switch region; other site
317655001871	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
317655001872	active site
317655001873	catalytic triad [active]
317655001874	oxyanion hole [active]
317655001875	switch loop; other site
317655001876	hypothetical protein; Provisional; Region: PRK02237
317655001877	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
317655001878	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
317655001879	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655001880	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655001881	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
317655001882	dimerization interface [polypeptide binding]; other site
317655001883	DNA polymerase III subunit beta; Validated; Region: PRK05643
317655001884	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
317655001885	putative DNA binding surface [nucleotide binding]; other site
317655001886	dimer interface [polypeptide binding]; other site
317655001887	beta-clamp/clamp loader binding surface; other site
317655001888	beta-clamp/translesion DNA polymerase binding surface; other site
317655001889	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
317655001890	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
317655001891	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
317655001892	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
317655001893	NlpC/P60 family; Region: NLPC_P60; pfam00877
317655001894	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
317655001895	interface (dimer of trimers) [polypeptide binding]; other site
317655001896	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
317655001897	Substrate-binding/catalytic site; other site
317655001898	Zn-binding sites [ion binding]; other site
317655001899	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
317655001900	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
317655001901	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
317655001902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
317655001903	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
317655001904	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
317655001905	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
317655001906	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
317655001907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655001908	FeS/SAM binding site; other site
317655001909	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
317655001910	Ion channel; Region: Ion_trans_2; pfam07885
317655001911	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
317655001912	TrkA-N domain; Region: TrkA_N; pfam02254
317655001913	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
317655001914	seryl-tRNA synthetase; Provisional; Region: PRK05431
317655001915	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
317655001916	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
317655001917	dimer interface [polypeptide binding]; other site
317655001918	active site
317655001919	motif 1; other site
317655001920	motif 2; other site
317655001921	motif 3; other site
317655001922	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
317655001923	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
317655001924	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
317655001925	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
317655001926	catalytic residues [active]
317655001927	Sulfatase; Region: Sulfatase; cl17466
317655001928	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
317655001929	GIY-YIG motif/motif A; other site
317655001930	putative active site [active]
317655001931	putative metal binding site [ion binding]; other site
317655001932	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655001933	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655001934	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655001935	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655001936	substrate binding site [chemical binding]; other site
317655001937	oxyanion hole (OAH) forming residues; other site
317655001938	trimer interface [polypeptide binding]; other site
317655001939	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
317655001940	putative substrate binding site [chemical binding]; other site
317655001941	active site
317655001942	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
317655001943	active site
317655001944	catalytic residues [active]
317655001945	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
317655001946	putative substrate binding site [chemical binding]; other site
317655001947	active site
317655001948	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
317655001949	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
317655001950	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655001951	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655001952	galactonate dehydratase; Provisional; Region: PRK14017
317655001953	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
317655001954	putative active site pocket [active]
317655001955	putative metal binding site [ion binding]; other site
317655001956	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
317655001957	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
317655001958	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
317655001959	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
317655001960	active site
317655001961	intersubunit interface [polypeptide binding]; other site
317655001962	catalytic residue [active]
317655001963	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
317655001964	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
317655001965	Transcriptional regulators [Transcription]; Region: FadR; COG2186
317655001966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655001967	DNA-binding site [nucleotide binding]; DNA binding site
317655001968	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
317655001969	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
317655001970	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
317655001971	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
317655001972	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
317655001973	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655001974	dimer interface [polypeptide binding]; other site
317655001975	conserved gate region; other site
317655001976	putative PBP binding loops; other site
317655001977	ABC-ATPase subunit interface; other site
317655001978	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
317655001979	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655001980	conserved gate region; other site
317655001981	putative PBP binding loops; other site
317655001982	ABC-ATPase subunit interface; other site
317655001983	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
317655001984	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655001985	Walker A/P-loop; other site
317655001986	ATP binding site [chemical binding]; other site
317655001987	Q-loop/lid; other site
317655001988	ABC transporter signature motif; other site
317655001989	Walker B; other site
317655001990	D-loop; other site
317655001991	H-loop/switch region; other site
317655001992	TOBE domain; Region: TOBE_2; pfam08402
317655001993	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
317655001994	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
317655001995	active site
317655001996	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
317655001997	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
317655001998	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
317655001999	G1 box; other site
317655002000	putative GEF interaction site [polypeptide binding]; other site
317655002001	GTP/Mg2+ binding site [chemical binding]; other site
317655002002	Switch I region; other site
317655002003	G2 box; other site
317655002004	G3 box; other site
317655002005	Switch II region; other site
317655002006	G4 box; other site
317655002007	G5 box; other site
317655002008	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
317655002009	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
317655002010	active site
317655002011	DNA polymerase IV; Validated; Region: PRK02406
317655002012	DNA binding site [nucleotide binding]
317655002013	Secreted protein acidic and rich in cysteine Ca binding region; Region: SPARC_Ca_bdg; pfam10591
317655002014	osmolarity response regulator; Provisional; Region: ompR; PRK09468
317655002015	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002016	active site
317655002017	phosphorylation site [posttranslational modification]
317655002018	intermolecular recognition site; other site
317655002019	dimerization interface [polypeptide binding]; other site
317655002020	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
317655002021	DNA binding site [nucleotide binding]
317655002022	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655002023	dimer interface [polypeptide binding]; other site
317655002024	phosphorylation site [posttranslational modification]
317655002025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655002026	ATP binding site [chemical binding]; other site
317655002027	Mg2+ binding site [ion binding]; other site
317655002028	G-X-G motif; other site
317655002029	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
317655002030	Uncharacterized conserved protein [Function unknown]; Region: COG3268
317655002031	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
317655002032	trimer interface [polypeptide binding]; other site
317655002033	active site
317655002034	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
317655002035	active site
317655002036	catalytic motif [active]
317655002037	Zn binding site [ion binding]; other site
317655002038	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
317655002039	active site
317655002040	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
317655002041	hypothetical protein; Provisional; Region: PRK02853
317655002042	replicative DNA helicase; Provisional; Region: PRK09165
317655002043	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
317655002044	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
317655002045	Walker A motif; other site
317655002046	ATP binding site [chemical binding]; other site
317655002047	Walker B motif; other site
317655002048	DNA binding loops [nucleotide binding]
317655002049	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
317655002050	GIY-YIG motif/motif A; other site
317655002051	putative active site [active]
317655002052	putative metal binding site [ion binding]; other site
317655002053	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
317655002054	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
317655002055	Active Sites [active]
317655002056	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
317655002057	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
317655002058	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
317655002059	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
317655002060	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
317655002061	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
317655002062	active site
317655002063	SAM binding site [chemical binding]; other site
317655002064	homodimer interface [polypeptide binding]; other site
317655002065	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
317655002066	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
317655002067	NAD(P) binding site [chemical binding]; other site
317655002068	catalytic residues [active]
317655002069	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655002070	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
317655002071	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
317655002072	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655002073	FMN binding site [chemical binding]; other site
317655002074	substrate binding site [chemical binding]; other site
317655002075	putative catalytic residue [active]
317655002076	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
317655002077	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
317655002078	dimerization interface [polypeptide binding]; other site
317655002079	ligand binding site [chemical binding]; other site
317655002080	NADP binding site [chemical binding]; other site
317655002081	catalytic site [active]
317655002082	Bacterial SH3 domain; Region: SH3_4; pfam06347
317655002083	Bacterial SH3 domain; Region: SH3_4; pfam06347
317655002084	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
317655002085	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655002086	dimer interface [polypeptide binding]; other site
317655002087	active site
317655002088	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
317655002089	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
317655002090	NAD(P) binding site [chemical binding]; other site
317655002091	catalytic residues [active]
317655002092	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
317655002093	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
317655002094	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
317655002095	Multicopper oxidase; Region: Cu-oxidase; pfam00394
317655002096	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
317655002097	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
317655002098	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
317655002099	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
317655002100	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655002101	RNA binding surface [nucleotide binding]; other site
317655002102	Chorismate mutase type II; Region: CM_2; cl00693
317655002103	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
317655002104	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
317655002105	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
317655002106	ATP cone domain; Region: ATP-cone; pfam03477
317655002107	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
317655002108	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
317655002109	dimer interface [polypeptide binding]; other site
317655002110	active site
317655002111	glycine-pyridoxal phosphate binding site [chemical binding]; other site
317655002112	folate binding site [chemical binding]; other site
317655002113	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
317655002114	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
317655002115	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
317655002116	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
317655002117	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655002118	catalytic residue [active]
317655002119	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
317655002120	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
317655002121	catalytic loop [active]
317655002122	iron binding site [ion binding]; other site
317655002123	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
317655002124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655002125	Walker A motif; other site
317655002126	ATP binding site [chemical binding]; other site
317655002127	Walker B motif; other site
317655002128	arginine finger; other site
317655002129	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
317655002130	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
317655002131	hypothetical protein; Validated; Region: PRK00153
317655002132	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
317655002133	Found in ATP-dependent protease La (LON); Region: LON; smart00464
317655002134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655002135	Walker A motif; other site
317655002136	ATP binding site [chemical binding]; other site
317655002137	Walker B motif; other site
317655002138	arginine finger; other site
317655002139	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
317655002140	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
317655002141	IHF dimer interface [polypeptide binding]; other site
317655002142	IHF - DNA interface [nucleotide binding]; other site
317655002143	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
317655002144	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
317655002145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002146	active site
317655002147	phosphorylation site [posttranslational modification]
317655002148	intermolecular recognition site; other site
317655002149	dimerization interface [polypeptide binding]; other site
317655002150	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
317655002151	DNA binding site [nucleotide binding]
317655002152	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655002153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655002154	ATP binding site [chemical binding]; other site
317655002155	Mg2+ binding site [ion binding]; other site
317655002156	G-X-G motif; other site
317655002157	DDE superfamily endonuclease; Region: DDE_3; pfam13358
317655002158	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
317655002159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
317655002160	Transposase; Region: DEDD_Tnp_IS110; pfam01548
317655002161	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
317655002162	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
317655002163	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
317655002164	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
317655002165	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
317655002166	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
317655002167	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
317655002168	homoserine dehydrogenase; Provisional; Region: PRK06349
317655002169	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
317655002170	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
317655002171	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
317655002172	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
317655002173	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
317655002174	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
317655002175	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
317655002176	Low molecular weight phosphatase family; Region: LMWPc; cd00115
317655002177	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
317655002178	active site
317655002179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002180	putative substrate translocation pore; other site
317655002181	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
317655002182	E-class dimer interface [polypeptide binding]; other site
317655002183	P-class dimer interface [polypeptide binding]; other site
317655002184	active site
317655002185	Cu2+ binding site [ion binding]; other site
317655002186	Zn2+ binding site [ion binding]; other site
317655002187	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
317655002188	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
317655002189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002190	active site
317655002191	phosphorylation site [posttranslational modification]
317655002192	intermolecular recognition site; other site
317655002193	dimerization interface [polypeptide binding]; other site
317655002194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
317655002195	DNA binding site [nucleotide binding]
317655002196	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
317655002197	PhoU domain; Region: PhoU; pfam01895
317655002198	PhoU domain; Region: PhoU; pfam01895
317655002199	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
317655002200	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
317655002201	Walker A/P-loop; other site
317655002202	ATP binding site [chemical binding]; other site
317655002203	Q-loop/lid; other site
317655002204	ABC transporter signature motif; other site
317655002205	Walker B; other site
317655002206	D-loop; other site
317655002207	H-loop/switch region; other site
317655002208	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
317655002209	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
317655002210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655002211	dimer interface [polypeptide binding]; other site
317655002212	conserved gate region; other site
317655002213	putative PBP binding loops; other site
317655002214	ABC-ATPase subunit interface; other site
317655002215	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
317655002216	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
317655002217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655002218	dimer interface [polypeptide binding]; other site
317655002219	conserved gate region; other site
317655002220	putative PBP binding loops; other site
317655002221	ABC-ATPase subunit interface; other site
317655002222	PBP superfamily domain; Region: PBP_like_2; cl17296
317655002223	Uncharacterized conserved protein [Function unknown]; Region: COG1359
317655002224	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
317655002225	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
317655002226	dimer interface [polypeptide binding]; other site
317655002227	active site
317655002228	citrylCoA binding site [chemical binding]; other site
317655002229	NADH binding [chemical binding]; other site
317655002230	cationic pore residues; other site
317655002231	oxalacetate/citrate binding site [chemical binding]; other site
317655002232	coenzyme A binding site [chemical binding]; other site
317655002233	catalytic triad [active]
317655002234	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
317655002235	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
317655002236	HIGH motif; other site
317655002237	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
317655002238	active site
317655002239	KMSKS motif; other site
317655002240	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
317655002241	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
317655002242	Competence protein; Region: Competence; pfam03772
317655002243	LexA repressor; Validated; Region: PRK00215
317655002244	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
317655002245	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
317655002246	Catalytic site [active]
317655002247	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
317655002248	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
317655002249	dimer interface [polypeptide binding]; other site
317655002250	putative functional site; other site
317655002251	putative MPT binding site; other site
317655002252	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
317655002253	trimer interface [polypeptide binding]; other site
317655002254	dimer interface [polypeptide binding]; other site
317655002255	putative active site [active]
317655002256	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
317655002257	active site
317655002258	ribulose/triose binding site [chemical binding]; other site
317655002259	phosphate binding site [ion binding]; other site
317655002260	substrate (anthranilate) binding pocket [chemical binding]; other site
317655002261	product (indole) binding pocket [chemical binding]; other site
317655002262	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
317655002263	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
317655002264	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
317655002265	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
317655002266	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
317655002267	glutamine binding [chemical binding]; other site
317655002268	catalytic triad [active]
317655002269	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
317655002270	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
317655002271	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
317655002272	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
317655002273	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
317655002274	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
317655002275	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
317655002276	GatB domain; Region: GatB_Yqey; smart00845
317655002277	trigger factor; Provisional; Region: tig; PRK01490
317655002278	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
317655002279	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
317655002280	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
317655002281	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
317655002282	minor groove reading motif; other site
317655002283	helix-hairpin-helix signature motif; other site
317655002284	active site
317655002285	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
317655002286	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
317655002287	catalytic loop [active]
317655002288	iron binding site [ion binding]; other site
317655002289	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
317655002290	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
317655002291	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
317655002292	integrase; Provisional; Region: PRK09692
317655002293	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
317655002294	active site
317655002295	Int/Topo IB signature motif; other site
317655002296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655002297	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
317655002298	Walker A motif; other site
317655002299	ATP binding site [chemical binding]; other site
317655002300	Walker B motif; other site
317655002301	arginine finger; other site
317655002302	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
317655002303	Integrase core domain; Region: rve; pfam00665
317655002304	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
317655002305	active site 2 [active]
317655002306	active site 1 [active]
317655002307	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655002308	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002309	substrate binding site [chemical binding]; other site
317655002310	oxyanion hole (OAH) forming residues; other site
317655002311	trimer interface [polypeptide binding]; other site
317655002312	enoyl-CoA hydratase; Provisional; Region: PRK06688
317655002313	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002314	substrate binding site [chemical binding]; other site
317655002315	oxyanion hole (OAH) forming residues; other site
317655002316	trimer interface [polypeptide binding]; other site
317655002317	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655002318	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655002319	active site
317655002320	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655002321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655002322	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
317655002323	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655002324	FMN binding site [chemical binding]; other site
317655002325	substrate binding site [chemical binding]; other site
317655002326	putative catalytic residue [active]
317655002327	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
317655002328	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
317655002329	NAD(P) binding site [chemical binding]; other site
317655002330	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
317655002331	classical (c) SDRs; Region: SDR_c; cd05233
317655002332	NAD(P) binding site [chemical binding]; other site
317655002333	active site
317655002334	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655002335	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655002336	active site
317655002337	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
317655002338	putative active site [active]
317655002339	putative substrate binding site [chemical binding]; other site
317655002340	ATP binding site [chemical binding]; other site
317655002341	MarR family; Region: MarR_2; pfam12802
317655002342	SnoaL-like domain; Region: SnoaL_4; pfam13577
317655002343	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
317655002344	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002345	short chain dehydrogenase; Provisional; Region: PRK07677
317655002346	NAD(P) binding site [chemical binding]; other site
317655002347	active site
317655002348	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002349	active site
317655002350	classical (c) SDRs; Region: SDR_c; cd05233
317655002351	NAD(P) binding site [chemical binding]; other site
317655002352	active site
317655002353	Transcriptional regulators [Transcription]; Region: FadR; COG2186
317655002354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655002355	DNA-binding site [nucleotide binding]; DNA binding site
317655002356	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
317655002357	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655002358	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
317655002359	acyl-activating enzyme (AAE) consensus motif; other site
317655002360	putative AMP binding site [chemical binding]; other site
317655002361	putative active site [active]
317655002362	putative CoA binding site [chemical binding]; other site
317655002363	short chain dehydrogenase; Provisional; Region: PRK07774
317655002364	classical (c) SDRs; Region: SDR_c; cd05233
317655002365	NAD(P) binding site [chemical binding]; other site
317655002366	active site
317655002367	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655002368	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
317655002369	NAD(P) binding site [chemical binding]; other site
317655002370	catalytic residues [active]
317655002371	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655002372	Cytochrome P450; Region: p450; cl12078
317655002373	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655002374	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655002375	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655002376	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
317655002377	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
317655002378	FAD binding site [chemical binding]; other site
317655002379	substrate binding site [chemical binding]; other site
317655002380	catalytic base [active]
317655002381	enoyl-CoA hydratase; Provisional; Region: PRK06190
317655002382	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002383	substrate binding site [chemical binding]; other site
317655002384	oxyanion hole (OAH) forming residues; other site
317655002385	trimer interface [polypeptide binding]; other site
317655002386	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
317655002387	short chain dehydrogenase; Provisional; Region: PRK07677
317655002388	NAD(P) binding site [chemical binding]; other site
317655002389	substrate binding site [chemical binding]; other site
317655002390	homotetramer interface [polypeptide binding]; other site
317655002391	active site
317655002392	homodimer interface [polypeptide binding]; other site
317655002393	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655002394	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002395	substrate binding site [chemical binding]; other site
317655002396	oxyanion hole (OAH) forming residues; other site
317655002397	trimer interface [polypeptide binding]; other site
317655002398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002400	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
317655002401	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002402	NAD(P) binding site [chemical binding]; other site
317655002403	active site
317655002404	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655002405	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655002406	acyl-activating enzyme (AAE) consensus motif; other site
317655002407	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655002408	AMP binding site [chemical binding]; other site
317655002409	active site
317655002410	acyl-activating enzyme (AAE) consensus motif; other site
317655002411	CoA binding site [chemical binding]; other site
317655002412	classical (c) SDRs; Region: SDR_c; cd05233
317655002413	NAD(P) binding site [chemical binding]; other site
317655002414	active site
317655002415	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
317655002416	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
317655002417	putative NAD(P) binding site [chemical binding]; other site
317655002418	putative active site [active]
317655002419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002420	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
317655002421	NAD(P) binding site [chemical binding]; other site
317655002422	active site
317655002423	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
317655002424	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655002425	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655002426	N-terminal plug; other site
317655002427	ligand-binding site [chemical binding]; other site
317655002428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002429	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655002430	putative substrate translocation pore; other site
317655002431	Amidohydrolase; Region: Amidohydro_2; pfam04909
317655002432	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655002433	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655002434	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
317655002435	lipid-transfer protein; Provisional; Region: PRK07855
317655002436	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
317655002437	active site
317655002438	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
317655002439	DUF35 OB-fold domain; Region: DUF35; pfam01796
317655002440	putative CoA-transferase; Provisional; Region: PRK11430
317655002441	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655002442	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655002443	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655002444	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
317655002445	putative active site [active]
317655002446	ATP binding site [chemical binding]; other site
317655002447	Phosphotransferase enzyme family; Region: APH; pfam01636
317655002448	putative substrate binding site [chemical binding]; other site
317655002449	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
317655002450	NAD(P) binding site [chemical binding]; other site
317655002451	3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428
317655002452	active site
317655002453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655002454	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
317655002455	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002456	NAD(P) binding site [chemical binding]; other site
317655002457	active site
317655002458	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
317655002459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002460	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
317655002461	DUF35 OB-fold domain; Region: DUF35; pfam01796
317655002462	lipid-transfer protein; Provisional; Region: PRK07855
317655002463	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
317655002464	active site
317655002465	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655002466	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655002467	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655002468	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
317655002469	NAD binding site [chemical binding]; other site
317655002470	catalytic residues [active]
317655002471	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655002472	Cytochrome P450; Region: p450; cl12078
317655002473	Amidohydrolase; Region: Amidohydro_2; pfam04909
317655002474	DUF35 OB-fold domain; Region: DUF35; pfam01796
317655002475	lipid-transfer protein; Provisional; Region: PRK07855
317655002476	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
317655002477	active site
317655002478	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
317655002479	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655002480	active site
317655002481	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655002482	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655002483	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002484	substrate binding site [chemical binding]; other site
317655002485	oxyanion hole (OAH) forming residues; other site
317655002486	trimer interface [polypeptide binding]; other site
317655002487	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655002488	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655002489	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655002490	acyl-activating enzyme (AAE) consensus motif; other site
317655002491	acyl-activating enzyme (AAE) consensus motif; other site
317655002492	AMP binding site [chemical binding]; other site
317655002493	active site
317655002494	CoA binding site [chemical binding]; other site
317655002495	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
317655002496	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655002497	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655002498	acyl-activating enzyme (AAE) consensus motif; other site
317655002499	acyl-activating enzyme (AAE) consensus motif; other site
317655002500	putative AMP binding site [chemical binding]; other site
317655002501	putative active site [active]
317655002502	putative CoA binding site [chemical binding]; other site
317655002503	CoA binding site [chemical binding]; other site
317655002504	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
317655002505	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655002506	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655002507	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655002508	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
317655002509	lycopene cyclase; Region: lycopene_cycl; TIGR01789
317655002510	SapC; Region: SapC; pfam07277
317655002511	Cupin-like domain; Region: Cupin_8; pfam13621
317655002512	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
317655002513	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
317655002514	active site
317655002515	catalytic residues [active]
317655002516	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655002517	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655002518	DNA binding site [nucleotide binding]
317655002519	domain linker motif; other site
317655002520	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
317655002521	putative dimerization interface [polypeptide binding]; other site
317655002522	putative ligand binding site [chemical binding]; other site
317655002523	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
317655002524	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655002525	FMN binding site [chemical binding]; other site
317655002526	substrate binding site [chemical binding]; other site
317655002527	putative catalytic residue [active]
317655002528	dihydroorotase; Validated; Region: pyrC; PRK09357
317655002529	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655002530	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
317655002531	active site
317655002532	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
317655002533	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
317655002534	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
317655002535	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
317655002536	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
317655002537	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
317655002538	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
317655002539	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
317655002540	BCCT family transporter; Region: BCCT; pfam02028
317655002541	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
317655002542	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
317655002543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002544	active site
317655002545	phosphorylation site [posttranslational modification]
317655002546	intermolecular recognition site; other site
317655002547	dimerization interface [polypeptide binding]; other site
317655002548	LytTr DNA-binding domain; Region: LytTR; smart00850
317655002549	Histidine kinase; Region: His_kinase; pfam06580
317655002550	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
317655002551	ATP binding site [chemical binding]; other site
317655002552	Mg2+ binding site [ion binding]; other site
317655002553	G-X-G motif; other site
317655002554	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
317655002555	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655002556	active site
317655002557	HIGH motif; other site
317655002558	nucleotide binding site [chemical binding]; other site
317655002559	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
317655002560	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
317655002561	active site
317655002562	KMSKS motif; other site
317655002563	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
317655002564	tRNA binding surface [nucleotide binding]; other site
317655002565	anticodon binding site; other site
317655002566	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
317655002567	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
317655002568	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655002569	PilZ domain; Region: PilZ; pfam07238
317655002570	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
317655002571	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655002572	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
317655002573	active site
317655002574	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
317655002575	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
317655002576	Patatin phospholipase; Region: DUF3734; pfam12536
317655002577	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655002578	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
317655002579	NAD(P) binding site [chemical binding]; other site
317655002580	active site
317655002581	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
317655002582	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
317655002583	metal binding site [ion binding]; metal-binding site
317655002584	putative dimer interface [polypeptide binding]; other site
317655002585	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655002586	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655002587	substrate binding site [chemical binding]; other site
317655002588	oxyanion hole (OAH) forming residues; other site
317655002589	trimer interface [polypeptide binding]; other site
317655002590	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
317655002591	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
317655002592	tetramer interface [polypeptide binding]; other site
317655002593	active site
317655002594	Mg2+/Mn2+ binding site [ion binding]; other site
317655002595	isocitrate lyase; Region: PLN02892
317655002596	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655002597	sequence-specific DNA binding site [nucleotide binding]; other site
317655002598	salt bridge; other site
317655002599	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
317655002600	Domain of unknown function (DUF955); Region: DUF955; pfam06114
317655002601	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
317655002602	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
317655002603	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
317655002604	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
317655002605	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655002606	N-terminal plug; other site
317655002607	ligand-binding site [chemical binding]; other site
317655002608	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
317655002609	Bacterial sugar transferase; Region: Bac_transf; pfam02397
317655002610	GAF domain; Region: GAF; pfam01590
317655002611	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655002612	ATP binding site [chemical binding]; other site
317655002613	Mg2+ binding site [ion binding]; other site
317655002614	G-X-G motif; other site
317655002615	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
317655002616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002617	active site
317655002618	phosphorylation site [posttranslational modification]
317655002619	intermolecular recognition site; other site
317655002620	dimerization interface [polypeptide binding]; other site
317655002621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655002622	Walker A motif; other site
317655002623	ATP binding site [chemical binding]; other site
317655002624	Walker B motif; other site
317655002625	arginine finger; other site
317655002626	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655002627	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
317655002628	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
317655002629	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655002630	DNA-binding site [nucleotide binding]; DNA binding site
317655002631	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
317655002632	putative FMN binding site [chemical binding]; other site
317655002633	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
317655002634	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002635	putative substrate translocation pore; other site
317655002636	POT family; Region: PTR2; cl17359
317655002637	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
317655002638	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
317655002639	active site
317655002640	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655002641	active site
317655002642	NnrU protein; Region: NnrU; pfam07298
317655002643	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
317655002644	active site
317655002645	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
317655002646	catalytic tetrad [active]
317655002647	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
317655002648	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
317655002649	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
317655002650	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
317655002651	active site
317655002652	substrate binding site [chemical binding]; other site
317655002653	metal binding site [ion binding]; metal-binding site
317655002654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
317655002655	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
317655002656	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
317655002657	dimer interface [polypeptide binding]; other site
317655002658	substrate binding site [chemical binding]; other site
317655002659	ATP binding site [chemical binding]; other site
317655002660	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655002661	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
317655002662	active site
317655002663	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
317655002664	RNA/DNA hybrid binding site [nucleotide binding]; other site
317655002665	active site
317655002666	short chain dehydrogenase; Provisional; Region: PRK06197
317655002667	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
317655002668	putative NAD(P) binding site [chemical binding]; other site
317655002669	active site
317655002670	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
317655002671	DNA methylase; Region: N6_N4_Mtase; pfam01555
317655002672	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
317655002673	dihydropteroate synthase; Region: DHPS; TIGR01496
317655002674	substrate binding pocket [chemical binding]; other site
317655002675	dimer interface [polypeptide binding]; other site
317655002676	inhibitor binding site; inhibition site
317655002677	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655002678	dimerization interface [polypeptide binding]; other site
317655002679	putative DNA binding site [nucleotide binding]; other site
317655002680	putative Zn2+ binding site [ion binding]; other site
317655002681	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
317655002682	putative hydrophobic ligand binding site [chemical binding]; other site
317655002683	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
317655002684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002685	active site
317655002686	phosphorylation site [posttranslational modification]
317655002687	intermolecular recognition site; other site
317655002688	dimerization interface [polypeptide binding]; other site
317655002689	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655002690	Walker A motif; other site
317655002691	ATP binding site [chemical binding]; other site
317655002692	Walker B motif; other site
317655002693	arginine finger; other site
317655002694	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655002695	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
317655002696	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
317655002697	ligand binding site [chemical binding]; other site
317655002698	homodimer interface [polypeptide binding]; other site
317655002699	NAD(P) binding site [chemical binding]; other site
317655002700	trimer interface B [polypeptide binding]; other site
317655002701	trimer interface A [polypeptide binding]; other site
317655002702	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
317655002703	pentamer interface [polypeptide binding]; other site
317655002704	dodecaamer interface [polypeptide binding]; other site
317655002705	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
317655002706	Fasciclin domain; Region: Fasciclin; pfam02469
317655002707	2-isopropylmalate synthase; Validated; Region: PRK03739
317655002708	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
317655002709	active site
317655002710	catalytic residues [active]
317655002711	metal binding site [ion binding]; metal-binding site
317655002712	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
317655002713	Uncharacterized conserved protein [Function unknown]; Region: COG2353
317655002714	PspC domain; Region: PspC; cl00864
317655002715	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
317655002716	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
317655002717	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
317655002718	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
317655002719	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655002720	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
317655002721	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655002722	DNA binding residues [nucleotide binding]
317655002723	DNA primase; Validated; Region: dnaG; PRK05667
317655002724	CHC2 zinc finger; Region: zf-CHC2; pfam01807
317655002725	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
317655002726	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
317655002727	active site
317655002728	metal binding site [ion binding]; metal-binding site
317655002729	interdomain interaction site; other site
317655002730	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
317655002731	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
317655002732	GIY-YIG motif/motif A; other site
317655002733	putative active site [active]
317655002734	putative metal binding site [ion binding]; other site
317655002735	Yqey-like protein; Region: YqeY; pfam09424
317655002736	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
317655002737	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
317655002738	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
317655002739	catalytic site [active]
317655002740	subunit interface [polypeptide binding]; other site
317655002741	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
317655002742	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
317655002743	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
317655002744	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
317655002745	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
317655002746	ATP-grasp domain; Region: ATP-grasp_4; cl17255
317655002747	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
317655002748	IMP binding site; other site
317655002749	dimer interface [polypeptide binding]; other site
317655002750	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
317655002751	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
317655002752	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
317655002753	Rhomboid family; Region: Rhomboid; cl11446
317655002754	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
317655002755	dimer interface [polypeptide binding]; other site
317655002756	ADP-ribose binding site [chemical binding]; other site
317655002757	active site
317655002758	nudix motif; other site
317655002759	metal binding site [ion binding]; metal-binding site
317655002760	Repair protein; Region: Repair_PSII; cl01535
317655002761	Repair protein; Region: Repair_PSII; pfam04536
317655002762	LemA family; Region: LemA; cl00742
317655002763	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
317655002764	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
317655002765	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
317655002766	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655002767	DNA binding residues [nucleotide binding]
317655002768	dimer interface [polypeptide binding]; other site
317655002769	putative metal binding site [ion binding]; other site
317655002770	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655002771	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
317655002772	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655002773	putative metal binding site [ion binding]; other site
317655002774	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
317655002775	Fasciclin domain; Region: Fasciclin; pfam02469
317655002776	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
317655002777	DNA photolyase; Region: DNA_photolyase; pfam00875
317655002778	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
317655002779	PAS fold; Region: PAS; pfam00989
317655002780	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655002781	putative active site [active]
317655002782	heme pocket [chemical binding]; other site
317655002783	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
317655002784	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655002785	DNA binding residues [nucleotide binding]
317655002786	dimerization interface [polypeptide binding]; other site
317655002787	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
317655002788	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655002789	Walker A/P-loop; other site
317655002790	ATP binding site [chemical binding]; other site
317655002791	Q-loop/lid; other site
317655002792	ABC transporter signature motif; other site
317655002793	Walker B; other site
317655002794	D-loop; other site
317655002795	H-loop/switch region; other site
317655002796	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
317655002797	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
317655002798	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
317655002799	ABC-ATPase subunit  interface; other site
317655002800	dimer interface [polypeptide binding]; other site
317655002801	putative PBP binding regions; other site
317655002802	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
317655002803	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
317655002804	intersubunit interface [polypeptide binding]; other site
317655002805	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
317655002806	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655002807	N-terminal plug; other site
317655002808	ligand-binding site [chemical binding]; other site
317655002809	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
317655002810	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655002811	dimer interface [polypeptide binding]; other site
317655002812	active site
317655002813	acetyl-CoA acetyltransferase; Provisional; Region: PRK06289
317655002814	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
317655002815	active site
317655002816	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
317655002817	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
317655002818	acyl-activating enzyme (AAE) consensus motif; other site
317655002819	active site
317655002820	AMP binding site [chemical binding]; other site
317655002821	substrate binding site [chemical binding]; other site
317655002822	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
317655002823	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
317655002824	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
317655002825	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655002826	FMN binding site [chemical binding]; other site
317655002827	substrate binding site [chemical binding]; other site
317655002828	putative catalytic residue [active]
317655002829	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655002830	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655002831	N-terminal plug; other site
317655002832	ligand-binding site [chemical binding]; other site
317655002833	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655002834	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655002835	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
317655002836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002837	H+ Antiporter protein; Region: 2A0121; TIGR00900
317655002838	putative substrate translocation pore; other site
317655002839	Sulfatase; Region: Sulfatase; cl17466
317655002840	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
317655002841	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
317655002842	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
317655002843	Domain of unknown function DUF11; Region: DUF11; cl17728
317655002844	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
317655002845	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
317655002846	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655002847	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655002848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5368
317655002849	Putative glucoamylase; Region: Glycoamylase; pfam10091
317655002850	beta-D-glucuronidase; Provisional; Region: PRK10150
317655002851	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
317655002852	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
317655002853	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
317655002854	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
317655002855	putative catalytic site [active]
317655002856	putative metal binding site [ion binding]; other site
317655002857	putative phosphate binding site [ion binding]; other site
317655002858	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
317655002859	beta-galactosidase; Region: BGL; TIGR03356
317655002860	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
317655002861	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655002862	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
317655002863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655002864	dimer interface [polypeptide binding]; other site
317655002865	conserved gate region; other site
317655002866	putative PBP binding loops; other site
317655002867	ABC-ATPase subunit interface; other site
317655002868	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
317655002869	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655002870	dimer interface [polypeptide binding]; other site
317655002871	conserved gate region; other site
317655002872	putative PBP binding loops; other site
317655002873	ABC-ATPase subunit interface; other site
317655002874	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
317655002875	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655002876	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655002877	DNA binding site [nucleotide binding]
317655002878	domain linker motif; other site
317655002879	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
317655002880	dimerization interface [polypeptide binding]; other site
317655002881	ligand binding site [chemical binding]; other site
317655002882	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
317655002883	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
317655002884	Walker A/P-loop; other site
317655002885	ATP binding site [chemical binding]; other site
317655002886	Q-loop/lid; other site
317655002887	ABC transporter signature motif; other site
317655002888	Walker B; other site
317655002889	D-loop; other site
317655002890	H-loop/switch region; other site
317655002891	TOBE domain; Region: TOBE_2; pfam08402
317655002892	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
317655002893	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
317655002894	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
317655002895	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
317655002896	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
317655002897	active site
317655002898	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
317655002899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655002900	S-adenosylmethionine binding site [chemical binding]; other site
317655002901	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655002902	binding surface
317655002903	Tetratricopeptide repeat; Region: TPR_16; pfam13432
317655002904	TPR motif; other site
317655002905	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
317655002906	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
317655002907	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
317655002908	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
317655002909	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
317655002910	PA/protease or protease-like domain interface [polypeptide binding]; other site
317655002911	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
317655002912	metal binding site [ion binding]; metal-binding site
317655002913	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
317655002914	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
317655002915	FAD binding pocket [chemical binding]; other site
317655002916	FAD binding motif [chemical binding]; other site
317655002917	phosphate binding motif [ion binding]; other site
317655002918	beta-alpha-beta structure motif; other site
317655002919	NAD binding pocket [chemical binding]; other site
317655002920	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
317655002921	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
317655002922	putative acyl-acceptor binding pocket; other site
317655002923	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
317655002924	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
317655002925	4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193
317655002926	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
317655002927	catalytic loop [active]
317655002928	iron binding site [ion binding]; other site
317655002929	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
317655002930	aldolase II superfamily protein; Provisional; Region: PRK07044
317655002931	intersubunit interface [polypeptide binding]; other site
317655002932	active site
317655002933	Zn2+ binding site [ion binding]; other site
317655002934	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
317655002935	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
317655002936	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
317655002937	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
317655002938	EVE domain; Region: EVE; pfam01878
317655002939	PilZ domain; Region: PilZ; pfam07238
317655002940	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
317655002941	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
317655002942	active site
317655002943	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
317655002944	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
317655002945	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
317655002946	dimer interface [polypeptide binding]; other site
317655002947	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655002948	catalytic residue [active]
317655002949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002950	putative substrate translocation pore; other site
317655002951	16S rRNA methyltransferase B; Provisional; Region: PRK10901
317655002952	NusB family; Region: NusB; pfam01029
317655002953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655002954	S-adenosylmethionine binding site [chemical binding]; other site
317655002955	SapC; Region: SapC; pfam07277
317655002956	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
317655002957	FAD binding domain; Region: FAD_binding_4; pfam01565
317655002958	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
317655002959	DEAD-like helicases superfamily; Region: DEXDc; smart00487
317655002960	ATP binding site [chemical binding]; other site
317655002961	Mg++ binding site [ion binding]; other site
317655002962	motif III; other site
317655002963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655002964	nucleotide binding region [chemical binding]; other site
317655002965	ATP-binding site [chemical binding]; other site
317655002966	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655002967	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655002968	Winged helix-turn helix; Region: HTH_29; pfam13551
317655002969	Integrase core domain; Region: rve; pfam00665
317655002970	Integrase core domain; Region: rve_3; pfam13683
317655002971	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
317655002972	Prostaglandin dehydrogenases; Region: PGDH; cd05288
317655002973	NAD(P) binding site [chemical binding]; other site
317655002974	substrate binding site [chemical binding]; other site
317655002975	dimer interface [polypeptide binding]; other site
317655002976	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
317655002977	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
317655002978	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
317655002979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655002980	S-adenosylmethionine binding site [chemical binding]; other site
317655002981	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
317655002982	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655002983	RNA binding surface [nucleotide binding]; other site
317655002984	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
317655002985	active site
317655002986	Response regulator receiver domain; Region: Response_reg; pfam00072
317655002987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655002988	active site
317655002989	phosphorylation site [posttranslational modification]
317655002990	intermolecular recognition site; other site
317655002991	dimerization interface [polypeptide binding]; other site
317655002992	muropeptide transporter; Reviewed; Region: ampG; PRK11902
317655002993	muropeptide transporter; Validated; Region: ampG; cl17669
317655002994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655002995	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
317655002996	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
317655002997	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
317655002998	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
317655002999	substrate binding site [chemical binding]; other site
317655003000	active site
317655003001	catalytic residues [active]
317655003002	heterodimer interface [polypeptide binding]; other site
317655003003	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
317655003004	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
317655003005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003006	catalytic residue [active]
317655003007	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
317655003008	active site
317655003009	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
317655003010	active site
317655003011	dimer interface [polypeptide binding]; other site
317655003012	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
317655003013	adenylosuccinate lyase; Provisional; Region: PRK07492
317655003014	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
317655003015	tetramer interface [polypeptide binding]; other site
317655003016	active site
317655003017	hypothetical protein; Reviewed; Region: PRK00024
317655003018	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
317655003019	MPN+ (JAMM) motif; other site
317655003020	Zinc-binding site [ion binding]; other site
317655003021	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
317655003022	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
317655003023	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
317655003024	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
317655003025	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
317655003026	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
317655003027	ATP synthase subunit C; Region: ATP-synt_C; cl00466
317655003028	Plant ATP synthase F0; Region: YMF19; pfam02326
317655003029	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
317655003030	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
317655003031	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655003032	NAD(P) binding site [chemical binding]; other site
317655003033	active site
317655003034	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
317655003035	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
317655003036	GIY-YIG motif/motif A; other site
317655003037	active site
317655003038	catalytic site [active]
317655003039	putative DNA binding site [nucleotide binding]; other site
317655003040	metal binding site [ion binding]; metal-binding site
317655003041	UvrB/uvrC motif; Region: UVR; pfam02151
317655003042	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
317655003043	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
317655003044	CoenzymeA binding site [chemical binding]; other site
317655003045	subunit interaction site [polypeptide binding]; other site
317655003046	PHB binding site; other site
317655003047	Recombination protein O N terminal; Region: RecO_N; pfam11967
317655003048	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
317655003049	tartrate dehydrogenase; Region: TTC; TIGR02089
317655003050	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
317655003051	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
317655003052	homodimer interface [polypeptide binding]; other site
317655003053	substrate-cofactor binding pocket; other site
317655003054	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003055	catalytic residue [active]
317655003056	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
317655003057	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
317655003058	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655003059	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
317655003060	dimerization interface [polypeptide binding]; other site
317655003061	TM2 domain; Region: TM2; pfam05154
317655003062	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
317655003063	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
317655003064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655003065	Mg2+ binding site [ion binding]; other site
317655003066	G-X-G motif; other site
317655003067	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
317655003068	anchoring element; other site
317655003069	dimer interface [polypeptide binding]; other site
317655003070	ATP binding site [chemical binding]; other site
317655003071	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
317655003072	active site
317655003073	putative metal-binding site [ion binding]; other site
317655003074	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
317655003075	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
317655003076	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
317655003077	CoenzymeA binding site [chemical binding]; other site
317655003078	subunit interaction site [polypeptide binding]; other site
317655003079	PHB binding site; other site
317655003080	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
317655003081	GcrA cell cycle regulator; Region: GcrA; cl11564
317655003082	ABC-2 type transporter; Region: ABC2_membrane; cl17235
317655003083	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
317655003084	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
317655003085	Yip1 domain; Region: Yip1; pfam04893
317655003086	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655003087	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655003088	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
317655003089	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655003090	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655003091	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655003092	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655003093	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655003094	putative S-transferase; Provisional; Region: PRK11752
317655003095	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
317655003096	C-terminal domain interface [polypeptide binding]; other site
317655003097	GSH binding site (G-site) [chemical binding]; other site
317655003098	dimer interface [polypeptide binding]; other site
317655003099	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
317655003100	dimer interface [polypeptide binding]; other site
317655003101	N-terminal domain interface [polypeptide binding]; other site
317655003102	active site
317655003103	Predicted membrane protein [Function unknown]; Region: COG4655
317655003104	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
317655003105	PAS domain; Region: PAS_9; pfam13426
317655003106	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
317655003107	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
317655003108	FAD binding site [chemical binding]; other site
317655003109	substrate binding site [chemical binding]; other site
317655003110	catalytic base [active]
317655003111	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
317655003112	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655003113	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
317655003114	active site
317655003115	Secretin and TonB N terminus short domain; Region: STN; smart00965
317655003116	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655003117	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
317655003118	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
317655003119	FecR protein; Region: FecR; pfam04773
317655003120	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
317655003121	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655003122	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
317655003123	Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625
317655003124	Autotransporter beta-domain; Region: Autotransporter; pfam03797
317655003125	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
317655003126	glucokinase, proteobacterial type; Region: glk; TIGR00749
317655003127	nucleotide binding site [chemical binding]; other site
317655003128	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
317655003129	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
317655003130	catalytic triad [active]
317655003131	Protein of unknown function (DUF808); Region: DUF808; cl01002
317655003132	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
317655003133	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
317655003134	Walker A/P-loop; other site
317655003135	ATP binding site [chemical binding]; other site
317655003136	Q-loop/lid; other site
317655003137	ABC transporter signature motif; other site
317655003138	Walker B; other site
317655003139	D-loop; other site
317655003140	H-loop/switch region; other site
317655003141	TOBE domain; Region: TOBE_2; pfam08402
317655003142	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
317655003143	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655003144	dimer interface [polypeptide binding]; other site
317655003145	conserved gate region; other site
317655003146	putative PBP binding loops; other site
317655003147	ABC-ATPase subunit interface; other site
317655003148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655003149	dimer interface [polypeptide binding]; other site
317655003150	conserved gate region; other site
317655003151	putative PBP binding loops; other site
317655003152	ABC-ATPase subunit interface; other site
317655003153	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
317655003154	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
317655003155	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
317655003156	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
317655003157	aminotransferase; Validated; Region: PRK07046
317655003158	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
317655003159	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655003160	catalytic residue [active]
317655003161	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
317655003162	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
317655003163	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
317655003164	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
317655003165	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
317655003166	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
317655003167	inhibitor-cofactor binding pocket; inhibition site
317655003168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003169	catalytic residue [active]
317655003170	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655003171	dimer interface [polypeptide binding]; other site
317655003172	phosphorylation site [posttranslational modification]
317655003173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655003174	ATP binding site [chemical binding]; other site
317655003175	Mg2+ binding site [ion binding]; other site
317655003176	G-X-G motif; other site
317655003177	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
317655003178	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
317655003179	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
317655003180	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655003181	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
317655003182	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655003183	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
317655003184	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
317655003185	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
317655003186	Type IV pili component [Cell motility and secretion]; Region: COG5461
317655003187	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
317655003188	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
317655003189	BON domain; Region: BON; pfam04972
317655003190	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
317655003191	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
317655003192	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
317655003193	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
317655003194	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
317655003195	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
317655003196	RNA/DNA hybrid binding site [nucleotide binding]; other site
317655003197	active site
317655003198	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
317655003199	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
317655003200	putative active site [active]
317655003201	putative substrate binding site [chemical binding]; other site
317655003202	ATP binding site [chemical binding]; other site
317655003203	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
317655003204	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
317655003205	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
317655003206	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
317655003207	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
317655003208	active site
317655003209	HIGH motif; other site
317655003210	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655003211	KMSK motif region; other site
317655003212	tRNA binding surface [nucleotide binding]; other site
317655003213	DALR anticodon binding domain; Region: DALR_1; smart00836
317655003214	anticodon binding site; other site
317655003215	Sporulation related domain; Region: SPOR; pfam05036
317655003216	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
317655003217	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
317655003218	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
317655003219	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
317655003220	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
317655003221	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
317655003222	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
317655003223	Predicted small secreted protein [Function unknown]; Region: COG5510
317655003224	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
317655003225	MgtE intracellular N domain; Region: MgtE_N; smart00924
317655003226	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
317655003227	Divalent cation transporter; Region: MgtE; pfam01769
317655003228	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
317655003229	active site
317655003230	Nitronate monooxygenase; Region: NMO; pfam03060
317655003231	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655003232	FMN binding site [chemical binding]; other site
317655003233	substrate binding site [chemical binding]; other site
317655003234	putative catalytic residue [active]
317655003235	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
317655003236	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
317655003237	dimerization interface [polypeptide binding]; other site
317655003238	active site
317655003239	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2; cl00208
317655003240	CAS motifs; other site
317655003241	active site
317655003242	H+ Antiporter protein; Region: 2A0121; TIGR00900
317655003243	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
317655003244	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
317655003245	MoaE interaction surface [polypeptide binding]; other site
317655003246	MoeB interaction surface [polypeptide binding]; other site
317655003247	thiocarboxylated glycine; other site
317655003248	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
317655003249	MoaE homodimer interface [polypeptide binding]; other site
317655003250	MoaD interaction [polypeptide binding]; other site
317655003251	active site residues [active]
317655003252	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
317655003253	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655003254	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
317655003255	dimerization interface [polypeptide binding]; other site
317655003256	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
317655003257	Ca2+ binding site [ion binding]; other site
317655003258	Glucose inhibited division protein A; Region: GIDA; pfam01134
317655003259	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
317655003260	YhhN-like protein; Region: YhhN; pfam07947
317655003261	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
317655003262	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
317655003263	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
317655003264	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
317655003265	catalytic triad [active]
317655003266	Protein of unknown function (DUF952); Region: DUF952; pfam06108
317655003267	DNA gyrase subunit A; Validated; Region: PRK05560
317655003268	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
317655003269	CAP-like domain; other site
317655003270	active site
317655003271	primary dimer interface [polypeptide binding]; other site
317655003272	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
317655003273	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
317655003274	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
317655003275	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
317655003276	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655003277	NAD(P) binding site [chemical binding]; other site
317655003278	active site
317655003279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655003280	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655003281	ATP binding site [chemical binding]; other site
317655003282	Mg2+ binding site [ion binding]; other site
317655003283	G-X-G motif; other site
317655003284	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655003285	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655003286	ligand binding site [chemical binding]; other site
317655003287	flexible hinge region; other site
317655003288	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
317655003289	putative switch regulator; other site
317655003290	non-specific DNA interactions [nucleotide binding]; other site
317655003291	DNA binding site [nucleotide binding]
317655003292	sequence specific DNA binding site [nucleotide binding]; other site
317655003293	putative cAMP binding site [chemical binding]; other site
317655003294	CTP synthetase; Validated; Region: pyrG; PRK05380
317655003295	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
317655003296	Catalytic site [active]
317655003297	active site
317655003298	UTP binding site [chemical binding]; other site
317655003299	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
317655003300	active site
317655003301	putative oxyanion hole; other site
317655003302	catalytic triad [active]
317655003303	Preprotein translocase SecG subunit; Region: SecG; pfam03840
317655003304	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
317655003305	triosephosphate isomerase; Provisional; Region: PRK14565
317655003306	substrate binding site [chemical binding]; other site
317655003307	dimer interface [polypeptide binding]; other site
317655003308	catalytic triad [active]
317655003309	SurA N-terminal domain; Region: SurA_N_3; cl07813
317655003310	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
317655003311	anthranilate synthase component I; Provisional; Region: PRK13573
317655003312	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
317655003313	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
317655003314	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
317655003315	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
317655003316	FtsX-like permease family; Region: FtsX; pfam02687
317655003317	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
317655003318	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
317655003319	Walker A/P-loop; other site
317655003320	ATP binding site [chemical binding]; other site
317655003321	Q-loop/lid; other site
317655003322	ABC transporter signature motif; other site
317655003323	Walker B; other site
317655003324	D-loop; other site
317655003325	H-loop/switch region; other site
317655003326	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
317655003327	catalytic residues [active]
317655003328	dimer interface [polypeptide binding]; other site
317655003329	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
317655003330	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
317655003331	putative active site [active]
317655003332	putative PHP Thumb interface [polypeptide binding]; other site
317655003333	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
317655003334	generic binding surface II; other site
317655003335	generic binding surface I; other site
317655003336	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
317655003337	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
317655003338	dimer interface [polypeptide binding]; other site
317655003339	acyl-activating enzyme (AAE) consensus motif; other site
317655003340	putative active site [active]
317655003341	AMP binding site [chemical binding]; other site
317655003342	putative CoA binding site [chemical binding]; other site
317655003343	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
317655003344	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655003345	FeS/SAM binding site; other site
317655003346	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
317655003347	MPT binding site; other site
317655003348	trimer interface [polypeptide binding]; other site
317655003349	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
317655003350	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655003351	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655003352	catalytic residue [active]
317655003353	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
317655003354	active site
317655003355	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
317655003356	hydroxyglutarate oxidase; Provisional; Region: PRK11728
317655003357	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
317655003358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655003359	TPR motif; other site
317655003360	binding surface
317655003361	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
317655003362	N-formylglutamate amidohydrolase; Region: FGase; cl01522
317655003363	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
317655003364	Uncharacterized conserved protein [Function unknown]; Region: COG0062
317655003365	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
317655003366	putative substrate binding site [chemical binding]; other site
317655003367	putative ATP binding site [chemical binding]; other site
317655003368	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
317655003369	MAPEG family; Region: MAPEG; pfam01124
317655003370	MAPEG family; Region: MAPEG; pfam01124
317655003371	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655003372	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655003373	H+ Antiporter protein; Region: 2A0121; TIGR00900
317655003374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655003375	putative substrate translocation pore; other site
317655003376	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
317655003377	dimer interface [polypeptide binding]; other site
317655003378	active site
317655003379	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655003380	catalytic residues [active]
317655003381	substrate binding site [chemical binding]; other site
317655003382	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
317655003383	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
317655003384	dimer interface [polypeptide binding]; other site
317655003385	active site
317655003386	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655003387	catalytic residues [active]
317655003388	substrate binding site [chemical binding]; other site
317655003389	Protein of unknown function, DUF486; Region: DUF486; cl01236
317655003390	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655003391	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
317655003392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655003393	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
317655003394	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
317655003395	tetramer interface [polypeptide binding]; other site
317655003396	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003397	catalytic residue [active]
317655003398	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
317655003399	YceI-like domain; Region: YceI; smart00867
317655003400	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
317655003401	putative FMN binding site [chemical binding]; other site
317655003402	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
317655003403	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
317655003404	substrate-cofactor binding pocket; other site
317655003405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003406	catalytic residue [active]
317655003407	glutamate racemase; Provisional; Region: PRK00865
317655003408	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
317655003409	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
317655003410	DNA protecting protein DprA; Region: dprA; TIGR00732
317655003411	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
317655003412	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
317655003413	active site
317655003414	interdomain interaction site; other site
317655003415	putative metal-binding site [ion binding]; other site
317655003416	nucleotide binding site [chemical binding]; other site
317655003417	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
317655003418	domain I; other site
317655003419	DNA binding groove [nucleotide binding]
317655003420	phosphate binding site [ion binding]; other site
317655003421	domain II; other site
317655003422	domain III; other site
317655003423	nucleotide binding site [chemical binding]; other site
317655003424	catalytic site [active]
317655003425	domain IV; other site
317655003426	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
317655003427	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
317655003428	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
317655003429	GTPase Era; Reviewed; Region: era; PRK00089
317655003430	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
317655003431	G1 box; other site
317655003432	GTP/Mg2+ binding site [chemical binding]; other site
317655003433	Switch I region; other site
317655003434	G2 box; other site
317655003435	Switch II region; other site
317655003436	G3 box; other site
317655003437	G4 box; other site
317655003438	G5 box; other site
317655003439	KH domain; Region: KH_2; pfam07650
317655003440	G-X-X-G motif; other site
317655003441	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
317655003442	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
317655003443	dimerization interface [polypeptide binding]; other site
317655003444	active site
317655003445	metal binding site [ion binding]; metal-binding site
317655003446	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
317655003447	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
317655003448	Catalytic site [active]
317655003449	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
317655003450	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
317655003451	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
317655003452	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
317655003453	active site
317655003454	dimer interface [polypeptide binding]; other site
317655003455	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
317655003456	dimer interface [polypeptide binding]; other site
317655003457	active site
317655003458	glutathione reductase; Validated; Region: PRK06116
317655003459	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655003460	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655003461	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655003462	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655003463	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655003464	non-specific DNA binding site [nucleotide binding]; other site
317655003465	salt bridge; other site
317655003466	sequence-specific DNA binding site [nucleotide binding]; other site
317655003467	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
317655003468	Domain of unknown function (DUF955); Region: DUF955; pfam06114
317655003469	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
317655003470	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655003471	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
317655003472	dimer interface [polypeptide binding]; other site
317655003473	substrate binding site [chemical binding]; other site
317655003474	metal binding site [ion binding]; metal-binding site
317655003475	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
317655003476	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
317655003477	active site
317655003478	substrate binding site [chemical binding]; other site
317655003479	coenzyme B12 binding site [chemical binding]; other site
317655003480	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
317655003481	B12 binding site [chemical binding]; other site
317655003482	cobalt ligand [ion binding]; other site
317655003483	biotin synthase; Region: bioB; TIGR00433
317655003484	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655003485	FeS/SAM binding site; other site
317655003486	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
317655003487	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
317655003488	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
317655003489	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
317655003490	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
317655003491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
317655003492	carboxyltransferase (CT) interaction site; other site
317655003493	biotinylation site [posttranslational modification]; other site
317655003494	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
317655003495	dimer interface [polypeptide binding]; other site
317655003496	putative tRNA-binding site [nucleotide binding]; other site
317655003497	Putative cyclase; Region: Cyclase; pfam04199
317655003498	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655003499	putative substrate translocation pore; other site
317655003500	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
317655003501	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
317655003502	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655003503	catalytic residue [active]
317655003504	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655003505	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655003506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
317655003507	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
317655003508	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
317655003509	prolyl-tRNA synthetase; Provisional; Region: PRK08661
317655003510	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
317655003511	dimer interface [polypeptide binding]; other site
317655003512	motif 1; other site
317655003513	active site
317655003514	motif 2; other site
317655003515	motif 3; other site
317655003516	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
317655003517	anticodon binding site; other site
317655003518	ribonuclease R; Region: RNase_R; TIGR02063
317655003519	RNB domain; Region: RNB; pfam00773
317655003520	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
317655003521	RNA binding site [nucleotide binding]; other site
317655003522	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655003523	non-specific DNA binding site [nucleotide binding]; other site
317655003524	salt bridge; other site
317655003525	sequence-specific DNA binding site [nucleotide binding]; other site
317655003526	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
317655003527	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
317655003528	E3 interaction surface; other site
317655003529	lipoyl attachment site [posttranslational modification]; other site
317655003530	e3 binding domain; Region: E3_binding; pfam02817
317655003531	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
317655003532	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
317655003533	putative active site [active]
317655003534	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
317655003535	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655003536	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655003537	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655003538	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
317655003539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655003540	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
317655003541	active site
317655003542	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
317655003543	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
317655003544	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655003545	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655003546	active site
317655003547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655003548	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655003549	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655003550	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
317655003551	acetyl-CoA acetyltransferase; Provisional; Region: PRK06025
317655003552	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655003553	dimer interface [polypeptide binding]; other site
317655003554	active site
317655003555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655003556	NAD(P) binding site [chemical binding]; other site
317655003557	active site
317655003558	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655003559	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655003560	active site
317655003561	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655003562	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655003563	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655003564	active site
317655003565	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
317655003566	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655003567	FMN binding site [chemical binding]; other site
317655003568	substrate binding site [chemical binding]; other site
317655003569	putative catalytic residue [active]
317655003570	AIPR protein; Region: AIPR; pfam10592
317655003571	transposase/IS protein; Provisional; Region: PRK09183
317655003572	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655003573	Walker A motif; other site
317655003574	ATP binding site [chemical binding]; other site
317655003575	Walker B motif; other site
317655003576	arginine finger; other site
317655003577	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
317655003578	Integrase core domain; Region: rve; pfam00665
317655003579	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
317655003580	Transglycosylase SLT domain; Region: SLT_2; pfam13406
317655003581	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655003582	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655003583	catalytic residue [active]
317655003584	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
317655003585	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
317655003586	Sporulation related domain; Region: SPOR; pfam05036
317655003587	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
317655003588	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
317655003589	thymidylate kinase; Validated; Region: tmk; PRK00698
317655003590	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
317655003591	TMP-binding site; other site
317655003592	ATP-binding site [chemical binding]; other site
317655003593	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
317655003594	DNA polymerase III subunit delta'; Validated; Region: PRK08485
317655003595	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
317655003596	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
317655003597	active site
317655003598	HIGH motif; other site
317655003599	KMSKS motif; other site
317655003600	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
317655003601	tRNA binding surface [nucleotide binding]; other site
317655003602	anticodon binding site; other site
317655003603	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
317655003604	active site
317655003605	putative hydrolase; Provisional; Region: PRK02113
317655003606	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
317655003607	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
317655003608	ANTAR domain; Region: ANTAR; pfam03861
317655003609	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
317655003610	NMT1-like family; Region: NMT1_2; pfam13379
317655003611	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
317655003612	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655003613	putative substrate translocation pore; other site
317655003614	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
317655003615	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
317655003616	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655003617	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
317655003618	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
317655003619	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
317655003620	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
317655003621	[2Fe-2S] cluster binding site [ion binding]; other site
317655003622	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
317655003623	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
317655003624	[4Fe-4S] binding site [ion binding]; other site
317655003625	molybdopterin cofactor binding site; other site
317655003626	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
317655003627	molybdopterin cofactor binding site; other site
317655003628	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
317655003629	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
317655003630	active site
317655003631	SAM binding site [chemical binding]; other site
317655003632	homodimer interface [polypeptide binding]; other site
317655003633	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
317655003634	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
317655003635	homodimer interface [polypeptide binding]; other site
317655003636	metal binding site [ion binding]; metal-binding site
317655003637	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
317655003638	homodimer interface [polypeptide binding]; other site
317655003639	active site
317655003640	putative chemical substrate binding site [chemical binding]; other site
317655003641	metal binding site [ion binding]; metal-binding site
317655003642	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
317655003643	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
317655003644	HflX GTPase family; Region: HflX; cd01878
317655003645	G1 box; other site
317655003646	GTP/Mg2+ binding site [chemical binding]; other site
317655003647	Switch I region; other site
317655003648	G2 box; other site
317655003649	G3 box; other site
317655003650	Switch II region; other site
317655003651	G4 box; other site
317655003652	G5 box; other site
317655003653	RNA-binding protein Hfq; Provisional; Region: PRK14091
317655003654	bacterial Hfq-like; Region: Hfq; cd01716
317655003655	hexamer interface [polypeptide binding]; other site
317655003656	Sm1 motif; other site
317655003657	RNA binding site [nucleotide binding]; other site
317655003658	Sm2 motif; other site
317655003659	bacterial Hfq-like; Region: Hfq; cd01716
317655003660	hexamer interface [polypeptide binding]; other site
317655003661	Sm1 motif; other site
317655003662	RNA binding site [nucleotide binding]; other site
317655003663	Sm2 motif; other site
317655003664	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
317655003665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655003666	active site
317655003667	phosphorylation site [posttranslational modification]
317655003668	intermolecular recognition site; other site
317655003669	dimerization interface [polypeptide binding]; other site
317655003670	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655003671	Walker A motif; other site
317655003672	ATP binding site [chemical binding]; other site
317655003673	Walker B motif; other site
317655003674	arginine finger; other site
317655003675	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655003676	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
317655003677	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
317655003678	dimerization interface [polypeptide binding]; other site
317655003679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655003680	dimer interface [polypeptide binding]; other site
317655003681	phosphorylation site [posttranslational modification]
317655003682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655003683	ATP binding site [chemical binding]; other site
317655003684	Mg2+ binding site [ion binding]; other site
317655003685	G-X-G motif; other site
317655003686	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
317655003687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655003688	active site
317655003689	phosphorylation site [posttranslational modification]
317655003690	intermolecular recognition site; other site
317655003691	dimerization interface [polypeptide binding]; other site
317655003692	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655003693	Walker A motif; other site
317655003694	ATP binding site [chemical binding]; other site
317655003695	Walker B motif; other site
317655003696	arginine finger; other site
317655003697	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
317655003698	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
317655003699	PAS domain; Region: PAS; smart00091
317655003700	putative active site [active]
317655003701	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655003702	dimer interface [polypeptide binding]; other site
317655003703	phosphorylation site [posttranslational modification]
317655003704	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655003705	ATP binding site [chemical binding]; other site
317655003706	Mg2+ binding site [ion binding]; other site
317655003707	G-X-G motif; other site
317655003708	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
317655003709	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
317655003710	FMN binding site [chemical binding]; other site
317655003711	active site
317655003712	catalytic residues [active]
317655003713	substrate binding site [chemical binding]; other site
317655003714	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
317655003715	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
317655003716	substrate binding site; other site
317655003717	dimer interface; other site
317655003718	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
317655003719	homotrimer interaction site [polypeptide binding]; other site
317655003720	zinc binding site [ion binding]; other site
317655003721	CDP-binding sites; other site
317655003722	Competence-damaged protein; Region: CinA; pfam02464
317655003723	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
317655003724	putative coenzyme Q binding site [chemical binding]; other site
317655003725	lipoyl synthase; Provisional; Region: PRK05481
317655003726	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655003727	FeS/SAM binding site; other site
317655003728	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
317655003729	active site clefts [active]
317655003730	zinc binding site [ion binding]; other site
317655003731	dimer interface [polypeptide binding]; other site
317655003732	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
317655003733	CoenzymeA binding site [chemical binding]; other site
317655003734	subunit interaction site [polypeptide binding]; other site
317655003735	PHB binding site; other site
317655003736	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
317655003737	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655003738	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655003739	ABC transporter; Region: ABC_tran_2; pfam12848
317655003740	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655003741	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
317655003742	putative active site [active]
317655003743	putative catalytic site [active]
317655003744	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655003745	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655003746	phosphorylation site [posttranslational modification]
317655003747	dimer interface [polypeptide binding]; other site
317655003748	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655003749	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655003750	putative DNA binding site [nucleotide binding]; other site
317655003751	putative Zn2+ binding site [ion binding]; other site
317655003752	AsnC family; Region: AsnC_trans_reg; pfam01037
317655003753	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
317655003754	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
317655003755	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655003756	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
317655003757	pantothenate kinase; Reviewed; Region: PRK13318
317655003758	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
317655003759	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
317655003760	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
317655003761	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
317655003762	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
317655003763	NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059
317655003764	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
317655003765	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
317655003766	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
317655003767	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
317655003768	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
317655003769	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
317655003770	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
317655003771	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
317655003772	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
317655003773	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
317655003774	4Fe-4S binding domain; Region: Fer4; pfam00037
317655003775	4Fe-4S binding domain; Region: Fer4; pfam00037
317655003776	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
317655003777	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
317655003778	NADH dehydrogenase subunit G; Validated; Region: PRK09130
317655003779	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
317655003780	catalytic loop [active]
317655003781	iron binding site [ion binding]; other site
317655003782	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
317655003783	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
317655003784	molybdopterin cofactor binding site; other site
317655003785	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
317655003786	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
317655003787	SLBB domain; Region: SLBB; pfam10531
317655003788	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
317655003789	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
317655003790	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
317655003791	putative dimer interface [polypeptide binding]; other site
317655003792	[2Fe-2S] cluster binding site [ion binding]; other site
317655003793	NADH dehydrogenase subunit D; Validated; Region: PRK06075
317655003794	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
317655003795	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
317655003796	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
317655003797	NADH dehydrogenase subunit B; Validated; Region: PRK06411
317655003798	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
317655003799	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
317655003800	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
317655003801	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
317655003802	active site
317655003803	dimerization interface [polypeptide binding]; other site
317655003804	elongation factor P; Validated; Region: PRK00529
317655003805	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
317655003806	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
317655003807	RNA binding site [nucleotide binding]; other site
317655003808	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
317655003809	RNA binding site [nucleotide binding]; other site
317655003810	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
317655003811	thiamine phosphate binding site [chemical binding]; other site
317655003812	active site
317655003813	pyrophosphate binding site [ion binding]; other site
317655003814	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
317655003815	catalytic residue [active]
317655003816	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
317655003817	Phosphoglycerate kinase; Region: PGK; pfam00162
317655003818	substrate binding site [chemical binding]; other site
317655003819	hinge regions; other site
317655003820	ADP binding site [chemical binding]; other site
317655003821	catalytic site [active]
317655003822	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
317655003823	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
317655003824	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
317655003825	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
317655003826	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
317655003827	TPP-binding site [chemical binding]; other site
317655003828	dimer interface [polypeptide binding]; other site
317655003829	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
317655003830	PYR/PP interface [polypeptide binding]; other site
317655003831	dimer interface [polypeptide binding]; other site
317655003832	TPP binding site [chemical binding]; other site
317655003833	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
317655003834	Cell division protein ZapA; Region: ZapA; pfam05164
317655003835	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
317655003836	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
317655003837	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
317655003838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
317655003839	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
317655003840	Domain of unknown function DUF11; Region: DUF11; pfam01345
317655003841	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
317655003842	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
317655003843	E3 interaction surface; other site
317655003844	lipoyl attachment site [posttranslational modification]; other site
317655003845	e3 binding domain; Region: E3_binding; pfam02817
317655003846	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
317655003847	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
317655003848	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
317655003849	alpha subunit interface [polypeptide binding]; other site
317655003850	TPP binding site [chemical binding]; other site
317655003851	heterodimer interface [polypeptide binding]; other site
317655003852	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
317655003853	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
317655003854	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
317655003855	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
317655003856	tetramer interface [polypeptide binding]; other site
317655003857	TPP-binding site [chemical binding]; other site
317655003858	heterodimer interface [polypeptide binding]; other site
317655003859	phosphorylation loop region [posttranslational modification]
317655003860	Thymidylate synthase; Region: Thymidylat_synt; pfam00303
317655003861	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
317655003862	dimerization interface [polypeptide binding]; other site
317655003863	active site
317655003864	RadC-like JAB domain; Region: RadC; pfam04002
317655003865	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
317655003866	Response regulator receiver domain; Region: Response_reg; pfam00072
317655003867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655003868	active site
317655003869	phosphorylation site [posttranslational modification]
317655003870	intermolecular recognition site; other site
317655003871	dimerization interface [polypeptide binding]; other site
317655003872	short chain dehydrogenase; Provisional; Region: PRK07576
317655003873	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655003874	NAD(P) binding site [chemical binding]; other site
317655003875	active site
317655003876	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655003877	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
317655003878	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
317655003879	catalytic site [active]
317655003880	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
317655003881	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
317655003882	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
317655003883	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655003884	active site
317655003885	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
317655003886	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
317655003887	cytochrome b; Provisional; Region: CYTB; MTH00156
317655003888	interchain domain interface [polypeptide binding]; other site
317655003889	intrachain domain interface; other site
317655003890	heme bH binding site [chemical binding]; other site
317655003891	Qi binding site; other site
317655003892	heme bL binding site [chemical binding]; other site
317655003893	Qo binding site; other site
317655003894	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
317655003895	interchain domain interface [polypeptide binding]; other site
317655003896	intrachain domain interface; other site
317655003897	Qi binding site; other site
317655003898	Qo binding site; other site
317655003899	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
317655003900	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
317655003901	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
317655003902	[2Fe-2S] cluster binding site [ion binding]; other site
317655003903	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
317655003904	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
317655003905	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
317655003906	lipoate-protein ligase B; Provisional; Region: PRK14341
317655003907	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655003908	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655003909	Winged helix-turn helix; Region: HTH_29; pfam13551
317655003910	Integrase core domain; Region: rve; pfam00665
317655003911	Integrase core domain; Region: rve_3; pfam13683
317655003912	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
317655003913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655003914	FeS/SAM binding site; other site
317655003915	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
317655003916	Ligand Binding Site [chemical binding]; other site
317655003917	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
317655003918	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
317655003919	dimerization interface [polypeptide binding]; other site
317655003920	domain crossover interface; other site
317655003921	redox-dependent activation switch; other site
317655003922	ornithine carbamoyltransferase; Provisional; Region: PRK00779
317655003923	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
317655003924	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
317655003925	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
317655003926	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
317655003927	inhibitor-cofactor binding pocket; inhibition site
317655003928	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655003929	catalytic residue [active]
317655003930	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
317655003931	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
317655003932	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
317655003933	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655003934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655003935	putative DNA binding site [nucleotide binding]; other site
317655003936	putative Zn2+ binding site [ion binding]; other site
317655003937	AsnC family; Region: AsnC_trans_reg; pfam01037
317655003938	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
317655003939	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
317655003940	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
317655003941	active site
317655003942	catalytic tetrad [active]
317655003943	Protein of unknown function, DUF; Region: DUF411; cl01142
317655003944	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
317655003945	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
317655003946	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
317655003947	glutaminase active site [active]
317655003948	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
317655003949	dimer interface [polypeptide binding]; other site
317655003950	active site
317655003951	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
317655003952	dimer interface [polypeptide binding]; other site
317655003953	active site
317655003954	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
317655003955	oligomeric interface; other site
317655003956	putative active site [active]
317655003957	homodimer interface [polypeptide binding]; other site
317655003958	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
317655003959	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
317655003960	Substrate binding site; other site
317655003961	Mg++ binding site; other site
317655003962	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
317655003963	active site
317655003964	substrate binding site [chemical binding]; other site
317655003965	CoA binding site [chemical binding]; other site
317655003966	phosphoglycolate phosphatase; Provisional; Region: PRK13222
317655003967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655003968	motif II; other site
317655003969	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
317655003970	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
317655003971	MarR family; Region: MarR_2; pfam12802
317655003972	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655003973	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655003974	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
317655003975	maleylacetoacetate isomerase; Region: maiA; TIGR01262
317655003976	C-terminal domain interface [polypeptide binding]; other site
317655003977	GSH binding site (G-site) [chemical binding]; other site
317655003978	putative dimer interface [polypeptide binding]; other site
317655003979	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
317655003980	dimer interface [polypeptide binding]; other site
317655003981	N-terminal domain interface [polypeptide binding]; other site
317655003982	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
317655003983	conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806
317655003984	Planctomycete cytochrome C; Region: PSCyt1; pfam07635
317655003985	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
317655003986	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
317655003987	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
317655003988	aspartate racemase; Region: asp_race; TIGR00035
317655003989	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
317655003990	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
317655003991	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
317655003992	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
317655003993	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
317655003994	putative active site; other site
317655003995	catalytic triad [active]
317655003996	putative dimer interface [polypeptide binding]; other site
317655003997	PilZ domain; Region: PilZ; pfam07238
317655003998	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
317655003999	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
317655004000	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
317655004001	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
317655004002	Cupin domain; Region: Cupin_2; pfam07883
317655004003	Cupin domain; Region: Cupin_2; pfam07883
317655004004	Predicted amidohydrolase [General function prediction only]; Region: COG0388
317655004005	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
317655004006	putative active site [active]
317655004007	catalytic triad [active]
317655004008	putative dimer interface [polypeptide binding]; other site
317655004009	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
317655004010	kynureninase; Region: kynureninase; TIGR01814
317655004011	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655004012	catalytic residue [active]
317655004013	Putative cyclase; Region: Cyclase; cl00814
317655004014	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
317655004015	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
317655004016	cofactor binding site; other site
317655004017	metal binding site [ion binding]; metal-binding site
317655004018	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655004019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655004020	putative DNA binding site [nucleotide binding]; other site
317655004021	putative Zn2+ binding site [ion binding]; other site
317655004022	AsnC family; Region: AsnC_trans_reg; pfam01037
317655004023	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655004024	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655004025	metal binding site [ion binding]; metal-binding site
317655004026	active site
317655004027	I-site; other site
317655004028	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
317655004029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004030	putative substrate translocation pore; other site
317655004031	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004032	PRC-barrel domain; Region: PRC; pfam05239
317655004033	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
317655004034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655004035	S-adenosylmethionine binding site [chemical binding]; other site
317655004036	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
317655004037	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
317655004038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655004039	catalytic residue [active]
317655004040	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
317655004041	Protein of unknown function (DUF983); Region: DUF983; cl02211
317655004042	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
317655004043	Subunit III/VIIa interface [polypeptide binding]; other site
317655004044	Phospholipid binding site [chemical binding]; other site
317655004045	Subunit I/III interface [polypeptide binding]; other site
317655004046	Subunit III/VIb interface [polypeptide binding]; other site
317655004047	Subunit III/VIa interface; other site
317655004048	Subunit III/Vb interface [polypeptide binding]; other site
317655004049	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
317655004050	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
317655004051	UbiA prenyltransferase family; Region: UbiA; pfam01040
317655004052	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
317655004053	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
317655004054	Subunit I/III interface [polypeptide binding]; other site
317655004055	D-pathway; other site
317655004056	Subunit I/VIIc interface [polypeptide binding]; other site
317655004057	Subunit I/IV interface [polypeptide binding]; other site
317655004058	Subunit I/II interface [polypeptide binding]; other site
317655004059	Low-spin heme (heme a) binding site [chemical binding]; other site
317655004060	Subunit I/VIIa interface [polypeptide binding]; other site
317655004061	Subunit I/VIa interface [polypeptide binding]; other site
317655004062	Dimer interface; other site
317655004063	Putative water exit pathway; other site
317655004064	Binuclear center (heme a3/CuB) [ion binding]; other site
317655004065	K-pathway; other site
317655004066	Subunit I/Vb interface [polypeptide binding]; other site
317655004067	Putative proton exit pathway; other site
317655004068	Subunit I/VIb interface; other site
317655004069	Subunit I/VIc interface [polypeptide binding]; other site
317655004070	Electron transfer pathway; other site
317655004071	Subunit I/VIIIb interface [polypeptide binding]; other site
317655004072	Subunit I/VIIb interface [polypeptide binding]; other site
317655004073	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
317655004074	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
317655004075	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
317655004076	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655004077	active site
317655004078	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
317655004079	active site
317655004080	hydrophilic channel; other site
317655004081	dimerization interface [polypeptide binding]; other site
317655004082	catalytic residues [active]
317655004083	active site lid [active]
317655004084	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
317655004085	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
317655004086	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
317655004087	Catalytic site [active]
317655004088	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
317655004089	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
317655004090	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
317655004091	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
317655004092	Amidohydrolase; Region: Amidohydro_4; pfam13147
317655004093	active site
317655004094	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
317655004095	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
317655004096	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
317655004097	catalytic core [active]
317655004098	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
317655004099	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
317655004100	DNA binding residues [nucleotide binding]
317655004101	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
317655004102	IHF dimer interface [polypeptide binding]; other site
317655004103	IHF - DNA interface [nucleotide binding]; other site
317655004104	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
317655004105	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
317655004106	dimer interface [polypeptide binding]; other site
317655004107	active site
317655004108	CoA binding pocket [chemical binding]; other site
317655004109	putative phosphate acyltransferase; Provisional; Region: PRK05331
317655004110	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
317655004111	MAPEG family; Region: MAPEG; pfam01124
317655004112	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
317655004113	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
317655004114	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
317655004115	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
317655004116	catalytic motif [active]
317655004117	Catalytic residue [active]
317655004118	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
317655004119	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
317655004120	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
317655004121	active site
317655004122	substrate binding pocket [chemical binding]; other site
317655004123	dimer interface [polypeptide binding]; other site
317655004124	Predicted permeases [General function prediction only]; Region: RarD; COG2962
317655004125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655004126	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
317655004127	CsbD-like; Region: CsbD; pfam05532
317655004128	Dehydroquinase class II; Region: DHquinase_II; pfam01220
317655004129	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
317655004130	trimer interface [polypeptide binding]; other site
317655004131	active site
317655004132	dimer interface [polypeptide binding]; other site
317655004133	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
317655004134	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
317655004135	carboxyltransferase (CT) interaction site; other site
317655004136	biotinylation site [posttranslational modification]; other site
317655004137	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
317655004138	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
317655004139	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
317655004140	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
317655004141	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
317655004142	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
317655004143	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
317655004144	mRNA/rRNA interface [nucleotide binding]; other site
317655004145	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
317655004146	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
317655004147	23S rRNA interface [nucleotide binding]; other site
317655004148	L7/L12 interface [polypeptide binding]; other site
317655004149	putative thiostrepton binding site; other site
317655004150	L25 interface [polypeptide binding]; other site
317655004151	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
317655004152	acyl-CoA thioesterase II; Region: tesB; TIGR00189
317655004153	active site
317655004154	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
317655004155	catalytic triad [active]
317655004156	dimer interface [polypeptide binding]; other site
317655004157	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
317655004158	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
317655004159	putative homodimer interface [polypeptide binding]; other site
317655004160	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
317655004161	heterodimer interface [polypeptide binding]; other site
317655004162	homodimer interface [polypeptide binding]; other site
317655004163	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
317655004164	MFS/sugar transport protein; Region: MFS_2; pfam13347
317655004165	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
317655004166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655004167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655004168	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
317655004169	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
317655004170	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655004171	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
317655004172	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
317655004173	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
317655004174	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
317655004175	Transglycosylase; Region: Transgly; pfam00912
317655004176	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
317655004177	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
317655004178	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
317655004179	active site
317655004180	catalytic triad [active]
317655004181	oxyanion hole [active]
317655004182	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655004183	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655004184	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655004185	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
317655004186	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
317655004187	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
317655004188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655004189	dimer interface [polypeptide binding]; other site
317655004190	phosphorylation site [posttranslational modification]
317655004191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655004192	ATP binding site [chemical binding]; other site
317655004193	Mg2+ binding site [ion binding]; other site
317655004194	G-X-G motif; other site
317655004195	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
317655004196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655004197	active site
317655004198	phosphorylation site [posttranslational modification]
317655004199	intermolecular recognition site; other site
317655004200	dimerization interface [polypeptide binding]; other site
317655004201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004202	Walker A motif; other site
317655004203	ATP binding site [chemical binding]; other site
317655004204	Walker B motif; other site
317655004205	arginine finger; other site
317655004206	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655004207	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
317655004208	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
317655004209	active site
317655004210	dimer interface [polypeptide binding]; other site
317655004211	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655004212	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655004213	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
317655004214	Uncharacterized membrane protein [Function unknown]; Region: COG3949
317655004215	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
317655004216	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655004217	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655004218	N-terminal plug; other site
317655004219	ligand-binding site [chemical binding]; other site
317655004220	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
317655004221	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
317655004222	active site
317655004223	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655004224	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655004225	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655004226	non-specific DNA binding site [nucleotide binding]; other site
317655004227	salt bridge; other site
317655004228	sequence-specific DNA binding site [nucleotide binding]; other site
317655004229	Cupin domain; Region: Cupin_2; pfam07883
317655004230	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
317655004231	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655004232	active site
317655004233	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655004234	phosphoserine phosphatase SerB; Region: serB; TIGR00338
317655004235	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
317655004236	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655004237	motif II; other site
317655004238	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
317655004239	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
317655004240	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
317655004241	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
317655004242	PYR/PP interface [polypeptide binding]; other site
317655004243	dimer interface [polypeptide binding]; other site
317655004244	TPP binding site [chemical binding]; other site
317655004245	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
317655004246	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
317655004247	TPP-binding site [chemical binding]; other site
317655004248	dimer interface [polypeptide binding]; other site
317655004249	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
317655004250	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
317655004251	putative valine binding site [chemical binding]; other site
317655004252	dimer interface [polypeptide binding]; other site
317655004253	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
317655004254	ketol-acid reductoisomerase; Provisional; Region: PRK05479
317655004255	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
317655004256	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
317655004257	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
317655004258	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
317655004259	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655004260	catalytic residue [active]
317655004261	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
317655004262	AAA domain; Region: AAA_26; pfam13500
317655004263	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
317655004264	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
317655004265	inhibitor-cofactor binding pocket; inhibition site
317655004266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655004267	catalytic residue [active]
317655004268	SurA N-terminal domain; Region: SurA_N; pfam09312
317655004269	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
317655004270	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
317655004271	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
317655004272	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
317655004273	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
317655004274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655004275	S-adenosylmethionine binding site [chemical binding]; other site
317655004276	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
317655004277	DNA-binding site [nucleotide binding]; DNA binding site
317655004278	RNA-binding motif; other site
317655004279	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
317655004280	rRNA binding site [nucleotide binding]; other site
317655004281	predicted 30S ribosome binding site; other site
317655004282	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
317655004283	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655004284	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
317655004285	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
317655004286	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
317655004287	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
317655004288	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
317655004289	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
317655004290	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
317655004291	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
317655004292	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
317655004293	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
317655004294	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
317655004295	DNA binding site [nucleotide binding]
317655004296	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
317655004297	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
317655004298	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
317655004299	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
317655004300	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
317655004301	RPB11 interaction site [polypeptide binding]; other site
317655004302	RPB12 interaction site [polypeptide binding]; other site
317655004303	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
317655004304	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
317655004305	RPB3 interaction site [polypeptide binding]; other site
317655004306	RPB1 interaction site [polypeptide binding]; other site
317655004307	RPB11 interaction site [polypeptide binding]; other site
317655004308	RPB10 interaction site [polypeptide binding]; other site
317655004309	enoyl-CoA hydratase; Provisional; Region: PRK05981
317655004310	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655004311	substrate binding site [chemical binding]; other site
317655004312	oxyanion hole (OAH) forming residues; other site
317655004313	trimer interface [polypeptide binding]; other site
317655004314	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
317655004315	Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341; cl17564
317655004316	Predicted periplasmic protein [Function unknown]; Region: COG3904
317655004317	Rrf2 family protein; Region: rrf2_super; TIGR00738
317655004318	Transcriptional regulator; Region: Rrf2; pfam02082
317655004319	Transcriptional regulator; Region: Rrf2; cl17282
317655004320	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
317655004321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
317655004322	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
317655004323	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
317655004324	hinge; other site
317655004325	active site
317655004326	cytidylate kinase; Provisional; Region: cmk; PRK00023
317655004327	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
317655004328	CMP-binding site; other site
317655004329	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
317655004330	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
317655004331	RNA binding site [nucleotide binding]; other site
317655004332	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
317655004333	RNA binding site [nucleotide binding]; other site
317655004334	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
317655004335	RNA binding site [nucleotide binding]; other site
317655004336	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
317655004337	RNA binding site [nucleotide binding]; other site
317655004338	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
317655004339	RNA binding site [nucleotide binding]; other site
317655004340	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
317655004341	RNA binding site [nucleotide binding]; other site
317655004342	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
317655004343	IHF dimer interface [polypeptide binding]; other site
317655004344	IHF - DNA interface [nucleotide binding]; other site
317655004345	ABC-2 type transporter; Region: ABC2_membrane; cl17235
317655004346	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
317655004347	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
317655004348	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
317655004349	Walker A/P-loop; other site
317655004350	ATP binding site [chemical binding]; other site
317655004351	Q-loop/lid; other site
317655004352	ABC transporter signature motif; other site
317655004353	Walker B; other site
317655004354	D-loop; other site
317655004355	H-loop/switch region; other site
317655004356	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
317655004357	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
317655004358	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
317655004359	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
317655004360	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
317655004361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655004362	active site
317655004363	phosphorylation site [posttranslational modification]
317655004364	intermolecular recognition site; other site
317655004365	dimerization interface [polypeptide binding]; other site
317655004366	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
317655004367	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655004368	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655004369	dimer interface [polypeptide binding]; other site
317655004370	phosphorylation site [posttranslational modification]
317655004371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655004372	ATP binding site [chemical binding]; other site
317655004373	Mg2+ binding site [ion binding]; other site
317655004374	G-X-G motif; other site
317655004375	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
317655004376	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
317655004377	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
317655004378	Subunit I/III interface [polypeptide binding]; other site
317655004379	Subunit III/IV interface [polypeptide binding]; other site
317655004380	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
317655004381	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
317655004382	D-pathway; other site
317655004383	Putative ubiquinol binding site [chemical binding]; other site
317655004384	Low-spin heme (heme b) binding site [chemical binding]; other site
317655004385	Putative water exit pathway; other site
317655004386	Binuclear center (heme o3/CuB) [ion binding]; other site
317655004387	K-pathway; other site
317655004388	Putative proton exit pathway; other site
317655004389	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
317655004390	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
317655004391	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
317655004392	metabolite-proton symporter; Region: 2A0106; TIGR00883
317655004393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004394	putative substrate translocation pore; other site
317655004395	benzoate transport; Region: 2A0115; TIGR00895
317655004396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004397	putative substrate translocation pore; other site
317655004398	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
317655004399	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
317655004400	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
317655004401	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
317655004402	potassium uptake protein; Region: kup; TIGR00794
317655004403	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
317655004404	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
317655004405	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
317655004406	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
317655004407	catalytic residues [active]
317655004408	central insert; other site
317655004409	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
317655004410	CcmE; Region: CcmE; pfam03100
317655004411	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
317655004412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
317655004413	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
317655004414	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
317655004415	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
317655004416	NAD(P) binding pocket [chemical binding]; other site
317655004417	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
317655004418	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
317655004419	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655004420	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
317655004421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655004422	Walker A/P-loop; other site
317655004423	ATP binding site [chemical binding]; other site
317655004424	Q-loop/lid; other site
317655004425	ABC transporter signature motif; other site
317655004426	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655004427	Walker B; other site
317655004428	D-loop; other site
317655004429	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
317655004430	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655004431	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
317655004432	active site
317655004433	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
317655004434	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
317655004435	CysD dimerization site [polypeptide binding]; other site
317655004436	G1 box; other site
317655004437	putative GEF interaction site [polypeptide binding]; other site
317655004438	GTP/Mg2+ binding site [chemical binding]; other site
317655004439	Switch I region; other site
317655004440	G2 box; other site
317655004441	G3 box; other site
317655004442	Switch II region; other site
317655004443	G4 box; other site
317655004444	G5 box; other site
317655004445	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
317655004446	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
317655004447	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
317655004448	ligand-binding site [chemical binding]; other site
317655004449	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
317655004450	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
317655004451	Active Sites [active]
317655004452	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655004453	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655004454	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
317655004455	dimerization interface [polypeptide binding]; other site
317655004456	isovaleryl-CoA dehydrogenase; Region: PLN02519
317655004457	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655004458	active site
317655004459	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
317655004460	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
317655004461	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
317655004462	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
317655004463	ATP-grasp domain; Region: ATP-grasp_4; cl17255
317655004464	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
317655004465	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
317655004466	carboxyltransferase (CT) interaction site; other site
317655004467	biotinylation site [posttranslational modification]; other site
317655004468	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
317655004469	putative active site [active]
317655004470	putative catalytic site [active]
317655004471	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
317655004472	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
317655004473	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
317655004474	putative active site [active]
317655004475	catalytic site [active]
317655004476	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
317655004477	putative active site [active]
317655004478	catalytic site [active]
317655004479	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
317655004480	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
317655004481	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
317655004482	FAD binding site [chemical binding]; other site
317655004483	substrate binding site [chemical binding]; other site
317655004484	catalytic residues [active]
317655004485	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
317655004486	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
317655004487	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
317655004488	DNA binding residues [nucleotide binding]
317655004489	putative dimer interface [polypeptide binding]; other site
317655004490	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
317655004491	amidophosphoribosyltransferase; Provisional; Region: PRK09123
317655004492	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
317655004493	active site
317655004494	tetramer interface [polypeptide binding]; other site
317655004495	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655004496	active site
317655004497	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655004498	NAD(P) binding site [chemical binding]; other site
317655004499	active site
317655004500	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655004501	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655004502	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
317655004503	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655004504	S-adenosylmethionine binding site [chemical binding]; other site
317655004505	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
317655004506	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
317655004507	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
317655004508	TPP-binding site [chemical binding]; other site
317655004509	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
317655004510	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
317655004511	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
317655004512	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
317655004513	dimer interface [polypeptide binding]; other site
317655004514	PYR/PP interface [polypeptide binding]; other site
317655004515	TPP binding site [chemical binding]; other site
317655004516	substrate binding site [chemical binding]; other site
317655004517	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
317655004518	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
317655004519	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
317655004520	putative active site [active]
317655004521	Ap4A binding site [chemical binding]; other site
317655004522	nudix motif; other site
317655004523	putative metal binding site [ion binding]; other site
317655004524	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
317655004525	Fe-S cluster binding site [ion binding]; other site
317655004526	DNA binding site [nucleotide binding]
317655004527	active site
317655004528	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
317655004529	catalytic center binding site [active]
317655004530	ATP binding site [chemical binding]; other site
317655004531	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655004532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655004533	NAD(P) binding site [chemical binding]; other site
317655004534	active site
317655004535	Protein of unknown function (DUF1109); Region: DUF1109; cl02071
317655004536	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
317655004537	DNA binding residues [nucleotide binding]
317655004538	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
317655004539	hypothetical protein; Provisional; Region: PRK05409
317655004540	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
317655004541	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
317655004542	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
317655004543	NAD binding site [chemical binding]; other site
317655004544	homodimer interface [polypeptide binding]; other site
317655004545	active site
317655004546	substrate binding site [chemical binding]; other site
317655004547	Predicted membrane protein [Function unknown]; Region: COG2119
317655004548	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
317655004549	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
317655004550	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
317655004551	Family of unknown function (DUF490); Region: DUF490; pfam04357
317655004552	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
317655004553	Surface antigen; Region: Bac_surface_Ag; pfam01103
317655004554	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
317655004555	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
317655004556	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
317655004557	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
317655004558	Uncharacterized conserved protein [Function unknown]; Region: COG0397
317655004559	hypothetical protein; Validated; Region: PRK00029
317655004560	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
317655004561	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
317655004562	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655004563	NAD binding site [chemical binding]; other site
317655004564	putative substrate binding site 2 [chemical binding]; other site
317655004565	putative substrate binding site 1 [chemical binding]; other site
317655004566	active site
317655004567	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
317655004568	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
317655004569	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
317655004570	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
317655004571	active site
317655004572	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
317655004573	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
317655004574	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
317655004575	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
317655004576	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
317655004577	inhibitor-cofactor binding pocket; inhibition site
317655004578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655004579	catalytic residue [active]
317655004580	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
317655004581	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
317655004582	putative trimer interface [polypeptide binding]; other site
317655004583	putative CoA binding site [chemical binding]; other site
317655004584	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
317655004585	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
317655004586	active site
317655004587	homodimer interface [polypeptide binding]; other site
317655004588	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
317655004589	NeuB family; Region: NeuB; pfam03102
317655004590	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
317655004591	NeuB binding interface [polypeptide binding]; other site
317655004592	putative substrate binding site [chemical binding]; other site
317655004593	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
317655004594	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655004595	NAD(P) binding site [chemical binding]; other site
317655004596	active site
317655004597	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
317655004598	ligand binding site; other site
317655004599	tetramer interface; other site
317655004600	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
317655004601	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
317655004602	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
317655004603	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
317655004604	NeuB family; Region: NeuB; pfam03102
317655004605	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
317655004606	NeuB binding interface [polypeptide binding]; other site
317655004607	putative substrate binding site [chemical binding]; other site
317655004608	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
317655004609	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
317655004610	Metal-binding active site; metal-binding site
317655004611	AP (apurinic/apyrimidinic) site pocket; other site
317655004612	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
317655004613	ligand binding site; other site
317655004614	tetramer interface; other site
317655004615	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
317655004616	Chain length determinant protein; Region: Wzz; pfam02706
317655004617	Chain length determinant protein; Region: Wzz; cl15801
317655004618	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
317655004619	O-Antigen ligase; Region: Wzy_C; pfam04932
317655004620	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
317655004621	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
317655004622	NAD(P) binding site [chemical binding]; other site
317655004623	homodimer interface [polypeptide binding]; other site
317655004624	substrate binding site [chemical binding]; other site
317655004625	active site
317655004626	Bacterial sugar transferase; Region: Bac_transf; pfam02397
317655004627	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655004628	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655004629	NAD(P) binding site [chemical binding]; other site
317655004630	active site
317655004631	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
317655004632	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
317655004633	SLBB domain; Region: SLBB; pfam10531
317655004634	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
317655004635	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
317655004636	active site
317655004637	metal binding site [ion binding]; metal-binding site
317655004638	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
317655004639	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
317655004640	active site
317655004641	homodimer interface [polypeptide binding]; other site
317655004642	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
317655004643	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
317655004644	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
317655004645	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
317655004646	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
317655004647	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
317655004648	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
317655004649	Substrate binding site; other site
317655004650	Cupin domain; Region: Cupin_2; cl17218
317655004651	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
317655004652	active site
317655004653	HslU subunit interaction site [polypeptide binding]; other site
317655004654	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
317655004655	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004656	Walker A motif; other site
317655004657	ATP binding site [chemical binding]; other site
317655004658	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
317655004659	Walker B motif; other site
317655004660	arginine finger; other site
317655004661	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
317655004662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655004663	non-specific DNA binding site [nucleotide binding]; other site
317655004664	salt bridge; other site
317655004665	sequence-specific DNA binding site [nucleotide binding]; other site
317655004666	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
317655004667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729
317655004668	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
317655004669	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
317655004670	FtsH Extracellular; Region: FtsH_ext; pfam06480
317655004671	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
317655004672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004673	Walker A motif; other site
317655004674	ATP binding site [chemical binding]; other site
317655004675	Walker B motif; other site
317655004676	arginine finger; other site
317655004677	Peptidase family M41; Region: Peptidase_M41; pfam01434
317655004678	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
317655004679	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
317655004680	PLD-like domain; Region: PLDc_2; pfam13091
317655004681	putative active site [active]
317655004682	catalytic site [active]
317655004683	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159
317655004684	PLD-like domain; Region: PLDc_2; pfam13091
317655004685	putative active site [active]
317655004686	catalytic site [active]
317655004687	Methyltransferase domain; Region: Methyltransf_31; pfam13847
317655004688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655004689	S-adenosylmethionine binding site [chemical binding]; other site
317655004690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004691	putative substrate translocation pore; other site
317655004692	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655004693	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
317655004694	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
317655004695	Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072
317655004696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004697	Walker A motif; other site
317655004698	ATP binding site [chemical binding]; other site
317655004699	Walker B motif; other site
317655004700	arginine finger; other site
317655004701	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004702	Walker A motif; other site
317655004703	ATP binding site [chemical binding]; other site
317655004704	Walker B motif; other site
317655004705	arginine finger; other site
317655004706	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
317655004707	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655004708	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
317655004709	dimerization interface [polypeptide binding]; other site
317655004710	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
317655004711	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
317655004712	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
317655004713	active site
317655004714	pyruvate phosphate dikinase; Provisional; Region: PRK09279
317655004715	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
317655004716	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
317655004717	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
317655004718	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
317655004719	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
317655004720	dimer interface [polypeptide binding]; other site
317655004721	motif 1; other site
317655004722	active site
317655004723	motif 2; other site
317655004724	motif 3; other site
317655004725	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655004726	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655004727	non-specific DNA binding site [nucleotide binding]; other site
317655004728	salt bridge; other site
317655004729	sequence-specific DNA binding site [nucleotide binding]; other site
317655004730	TraB family; Region: TraB; pfam01963
317655004731	TraB family; Region: TraB; pfam01963
317655004732	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
317655004733	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
317655004734	5S rRNA interface [nucleotide binding]; other site
317655004735	CTC domain interface [polypeptide binding]; other site
317655004736	L16 interface [polypeptide binding]; other site
317655004737	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
317655004738	putative active site [active]
317655004739	catalytic residue [active]
317655004740	short chain dehydrogenase; Provisional; Region: PRK06914
317655004741	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
317655004742	NADP binding site [chemical binding]; other site
317655004743	active site
317655004744	steroid binding site; other site
317655004745	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
317655004746	GTP-binding protein YchF; Reviewed; Region: PRK09601
317655004747	YchF GTPase; Region: YchF; cd01900
317655004748	G1 box; other site
317655004749	GTP/Mg2+ binding site [chemical binding]; other site
317655004750	Switch I region; other site
317655004751	G2 box; other site
317655004752	Switch II region; other site
317655004753	G3 box; other site
317655004754	G4 box; other site
317655004755	G5 box; other site
317655004756	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
317655004757	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
317655004758	GIY-YIG motif/motif A; other site
317655004759	active site
317655004760	catalytic site [active]
317655004761	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
317655004762	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
317655004763	DNA binding residues [nucleotide binding]
317655004764	dimer interface [polypeptide binding]; other site
317655004765	mercury binding site [ion binding]; other site
317655004766	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
317655004767	PhoD-like phosphatase; Region: PhoD; pfam09423
317655004768	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
317655004769	putative active site [active]
317655004770	putative metal binding site [ion binding]; other site
317655004771	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
317655004772	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
317655004773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655004774	ATP binding site [chemical binding]; other site
317655004775	Mg2+ binding site [ion binding]; other site
317655004776	G-X-G motif; other site
317655004777	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
317655004778	ATP binding site [chemical binding]; other site
317655004779	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
317655004780	rod shape-determining protein MreB; Provisional; Region: PRK13927
317655004781	MreB and similar proteins; Region: MreB_like; cd10225
317655004782	nucleotide binding site [chemical binding]; other site
317655004783	Mg binding site [ion binding]; other site
317655004784	putative protofilament interaction site [polypeptide binding]; other site
317655004785	RodZ interaction site [polypeptide binding]; other site
317655004786	rod shape-determining protein MreC; Provisional; Region: PRK13922
317655004787	rod shape-determining protein MreC; Region: MreC; pfam04085
317655004788	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
317655004789	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
317655004790	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
317655004791	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
317655004792	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655004793	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655004794	active site
317655004795	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
317655004796	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655004797	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655004798	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
317655004799	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655004800	substrate binding site [chemical binding]; other site
317655004801	oxyanion hole (OAH) forming residues; other site
317655004802	trimer interface [polypeptide binding]; other site
317655004803	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655004804	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655004805	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655004806	active site
317655004807	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655004808	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655004809	active site
317655004810	acetyl-CoA acetyltransferase; Provisional; Region: PRK06025
317655004811	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655004812	dimer interface [polypeptide binding]; other site
317655004813	active site
317655004814	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
317655004815	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655004816	FMN binding site [chemical binding]; other site
317655004817	substrate binding site [chemical binding]; other site
317655004818	putative catalytic residue [active]
317655004819	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
317655004820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655004821	Walker A motif; other site
317655004822	ATP binding site [chemical binding]; other site
317655004823	Walker B motif; other site
317655004824	arginine finger; other site
317655004825	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
317655004826	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
317655004827	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
317655004828	dimer interface [polypeptide binding]; other site
317655004829	putative CheW interface [polypeptide binding]; other site
317655004830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
317655004831	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
317655004832	Protein of unknown function (DUF817); Region: DUF817; pfam05675
317655004833	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
317655004834	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
317655004835	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
317655004836	active site
317655004837	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
317655004838	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
317655004839	putative heme binding site [chemical binding]; other site
317655004840	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
317655004841	GIY-YIG motif/motif A; other site
317655004842	putative active site [active]
317655004843	putative metal binding site [ion binding]; other site
317655004844	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
317655004845	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
317655004846	active site
317655004847	HIGH motif; other site
317655004848	dimer interface [polypeptide binding]; other site
317655004849	KMSKS motif; other site
317655004850	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655004851	RNA binding surface [nucleotide binding]; other site
317655004852	PilZ domain; Region: PilZ; pfam07238
317655004853	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
317655004854	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
317655004855	generic binding surface II; other site
317655004856	ssDNA binding site; other site
317655004857	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655004858	ATP binding site [chemical binding]; other site
317655004859	putative Mg++ binding site [ion binding]; other site
317655004860	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655004861	nucleotide binding region [chemical binding]; other site
317655004862	ATP-binding site [chemical binding]; other site
317655004863	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
317655004864	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
317655004865	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
317655004866	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655004867	ATP binding site [chemical binding]; other site
317655004868	putative Mg++ binding site [ion binding]; other site
317655004869	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655004870	nucleotide binding region [chemical binding]; other site
317655004871	ATP-binding site [chemical binding]; other site
317655004872	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
317655004873	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655004874	metal binding site [ion binding]; metal-binding site
317655004875	active site
317655004876	I-site; other site
317655004877	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655004878	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
317655004879	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655004880	FeS/SAM binding site; other site
317655004881	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
317655004882	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
317655004883	ATP-NAD kinase; Region: NAD_kinase; pfam01513
317655004884	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
317655004885	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
317655004886	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655004887	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655004888	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
317655004889	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
317655004890	active site
317655004891	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
317655004892	dimer interface [polypeptide binding]; other site
317655004893	non-prolyl cis peptide bond; other site
317655004894	insertion regions; other site
317655004895	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
317655004896	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
317655004897	active site
317655004898	catalytic tetrad [active]
317655004899	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655004900	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655004901	DNA binding site [nucleotide binding]
317655004902	domain linker motif; other site
317655004903	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
317655004904	putative ligand binding site [chemical binding]; other site
317655004905	putative dimerization interface [polypeptide binding]; other site
317655004906	alpha-glucosidase; Provisional; Region: PRK10426
317655004907	Iron/zinc purple acid phosphatase-like protein C; Region: Metallophos_C; pfam14008
317655004908	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
317655004909	putative active site [active]
317655004910	putative catalytic site [active]
317655004911	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655004912	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655004913	N-terminal plug; other site
317655004914	ligand-binding site [chemical binding]; other site
317655004915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655004916	D-galactonate transporter; Region: 2A0114; TIGR00893
317655004917	putative substrate translocation pore; other site
317655004918	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
317655004919	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
317655004920	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
317655004921	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
317655004922	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
317655004923	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
317655004924	FixH; Region: FixH; pfam05751
317655004925	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
317655004926	4Fe-4S binding domain; Region: Fer4_5; pfam12801
317655004927	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
317655004928	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
317655004929	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
317655004930	Cytochrome c; Region: Cytochrom_C; pfam00034
317655004931	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
317655004932	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
317655004933	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
317655004934	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
317655004935	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
317655004936	Low-spin heme binding site [chemical binding]; other site
317655004937	Putative water exit pathway; other site
317655004938	Binuclear center (active site) [active]
317655004939	Putative proton exit pathway; other site
317655004940	OmpW family; Region: OmpW; pfam03922
317655004941	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655004942	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655004943	ligand binding site [chemical binding]; other site
317655004944	flexible hinge region; other site
317655004945	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
317655004946	putative switch regulator; other site
317655004947	non-specific DNA interactions [nucleotide binding]; other site
317655004948	DNA binding site [nucleotide binding]
317655004949	sequence specific DNA binding site [nucleotide binding]; other site
317655004950	putative cAMP binding site [chemical binding]; other site
317655004951	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
317655004952	Ligand Binding Site [chemical binding]; other site
317655004953	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
317655004954	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
317655004955	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655004956	Radical SAM superfamily; Region: Radical_SAM; pfam04055
317655004957	FeS/SAM binding site; other site
317655004958	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
317655004959	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
317655004960	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
317655004961	B12 binding site [chemical binding]; other site
317655004962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655004963	FeS/SAM binding site; other site
317655004964	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
317655004965	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
317655004966	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655004967	DNA-binding site [nucleotide binding]; DNA binding site
317655004968	UTRA domain; Region: UTRA; pfam07702
317655004969	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
317655004970	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655004971	active site
317655004972	imidazolonepropionase; Validated; Region: PRK09356
317655004973	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
317655004974	active site
317655004975	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
317655004976	active sites [active]
317655004977	tetramer interface [polypeptide binding]; other site
317655004978	N-formylglutamate amidohydrolase; Region: FGase; cl01522
317655004979	urocanate hydratase; Provisional; Region: PRK05414
317655004980	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655004981	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
317655004982	active site
317655004983	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
317655004984	Uncharacterized conserved protein [Function unknown]; Region: COG3777
317655004985	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
317655004986	active site 2 [active]
317655004987	active site 1 [active]
317655004988	MASE1; Region: MASE1; pfam05231
317655004989	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655004990	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655004991	metal binding site [ion binding]; metal-binding site
317655004992	active site
317655004993	I-site; other site
317655004994	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655004995	WHG domain; Region: WHG; pfam13305
317655004996	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
317655004997	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
317655004998	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
317655004999	L11 interface [polypeptide binding]; other site
317655005000	putative EF-Tu interaction site [polypeptide binding]; other site
317655005001	putative EF-G interaction site [polypeptide binding]; other site
317655005002	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
317655005003	23S rRNA interface [nucleotide binding]; other site
317655005004	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
317655005005	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
317655005006	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
317655005007	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
317655005008	amino acid transporter; Region: 2A0306; TIGR00909
317655005009	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
317655005010	GTPase CgtA; Reviewed; Region: obgE; PRK12299
317655005011	GTP1/OBG; Region: GTP1_OBG; pfam01018
317655005012	Obg GTPase; Region: Obg; cd01898
317655005013	G1 box; other site
317655005014	GTP/Mg2+ binding site [chemical binding]; other site
317655005015	Switch I region; other site
317655005016	G2 box; other site
317655005017	G3 box; other site
317655005018	Switch II region; other site
317655005019	G4 box; other site
317655005020	G5 box; other site
317655005021	Methyltransferase domain; Region: Methyltransf_31; pfam13847
317655005022	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655005023	S-adenosylmethionine binding site [chemical binding]; other site
317655005024	recombination protein F; Reviewed; Region: recF; PRK00064
317655005025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655005026	Walker A/P-loop; other site
317655005027	ATP binding site [chemical binding]; other site
317655005028	Q-loop/lid; other site
317655005029	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655005030	ABC transporter signature motif; other site
317655005031	Walker B; other site
317655005032	D-loop; other site
317655005033	H-loop/switch region; other site
317655005034	PspC domain; Region: PspC; pfam04024
317655005035	2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291
317655005036	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
317655005037	NADP binding site [chemical binding]; other site
317655005038	dimer interface [polypeptide binding]; other site
317655005039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655005040	non-specific DNA binding site [nucleotide binding]; other site
317655005041	salt bridge; other site
317655005042	sequence-specific DNA binding site [nucleotide binding]; other site
317655005043	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
317655005044	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
317655005045	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
317655005046	Protein export membrane protein; Region: SecD_SecF; pfam02355
317655005047	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
317655005048	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
317655005049	Preprotein translocase subunit; Region: YajC; pfam02699
317655005050	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
317655005051	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
317655005052	NAD(P) binding site [chemical binding]; other site
317655005053	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
317655005054	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
317655005055	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
317655005056	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
317655005057	putative hydrophobic ligand binding site [chemical binding]; other site
317655005058	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
317655005059	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
317655005060	motif 1; other site
317655005061	active site
317655005062	motif 2; other site
317655005063	motif 3; other site
317655005064	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
317655005065	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655005066	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
317655005067	putative C-terminal domain interface [polypeptide binding]; other site
317655005068	putative GSH binding site (G-site) [chemical binding]; other site
317655005069	putative dimer interface [polypeptide binding]; other site
317655005070	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
317655005071	N-terminal domain interface [polypeptide binding]; other site
317655005072	dimer interface [polypeptide binding]; other site
317655005073	substrate binding pocket (H-site) [chemical binding]; other site
317655005074	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
317655005075	putative active site [active]
317655005076	Mn binding site [ion binding]; other site
317655005077	recombinase A; Provisional; Region: recA; PRK09354
317655005078	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
317655005079	hexamer interface [polypeptide binding]; other site
317655005080	Walker A motif; other site
317655005081	ATP binding site [chemical binding]; other site
317655005082	Walker B motif; other site
317655005083	cheY-homologous receiver domain; Region: REC; smart00448
317655005084	active site
317655005085	phosphorylation site [posttranslational modification]
317655005086	intermolecular recognition site; other site
317655005087	dimerization interface [polypeptide binding]; other site
317655005088	PAS domain; Region: PAS; smart00091
317655005089	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655005090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655005091	dimer interface [polypeptide binding]; other site
317655005092	phosphorylation site [posttranslational modification]
317655005093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655005094	ATP binding site [chemical binding]; other site
317655005095	Mg2+ binding site [ion binding]; other site
317655005096	G-X-G motif; other site
317655005097	Response regulator receiver domain; Region: Response_reg; pfam00072
317655005098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655005099	active site
317655005100	phosphorylation site [posttranslational modification]
317655005101	intermolecular recognition site; other site
317655005102	dimerization interface [polypeptide binding]; other site
317655005103	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
317655005104	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
317655005105	active site
317655005106	Zn binding site [ion binding]; other site
317655005107	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
317655005108	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
317655005109	SmpB-tmRNA interface; other site
317655005110	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
317655005111	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
317655005112	dimer interface [polypeptide binding]; other site
317655005113	active site
317655005114	catalytic residue [active]
317655005115	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
317655005116	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655005117	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655005118	catalytic residue [active]
317655005119	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
317655005120	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
317655005121	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
317655005122	Caspase domain; Region: Peptidase_C14; pfam00656
317655005123	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
317655005124	Sel1-like repeats; Region: SEL1; smart00671
317655005125	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
317655005126	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
317655005127	amidase catalytic site [active]
317655005128	Zn binding residues [ion binding]; other site
317655005129	substrate binding site [chemical binding]; other site
317655005130	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
317655005131	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
317655005132	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
317655005133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655005134	active site
317655005135	phosphorylation site [posttranslational modification]
317655005136	intermolecular recognition site; other site
317655005137	dimerization interface [polypeptide binding]; other site
317655005138	CheB methylesterase; Region: CheB_methylest; pfam01339
317655005139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655005140	Response regulator receiver domain; Region: Response_reg; pfam00072
317655005141	active site
317655005142	phosphorylation site [posttranslational modification]
317655005143	intermolecular recognition site; other site
317655005144	dimerization interface [polypeptide binding]; other site
317655005145	CheW-like domain; Region: CheW; pfam01584
317655005146	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
317655005147	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
317655005148	putative binding surface; other site
317655005149	active site
317655005150	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
317655005151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655005152	ATP binding site [chemical binding]; other site
317655005153	Mg2+ binding site [ion binding]; other site
317655005154	G-X-G motif; other site
317655005155	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
317655005156	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
317655005157	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
317655005158	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655005159	RNA binding surface [nucleotide binding]; other site
317655005160	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
317655005161	active site
317655005162	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
317655005163	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
317655005164	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655005165	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655005166	DNA binding residues [nucleotide binding]
317655005167	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
317655005168	LytTr DNA-binding domain; Region: LytTR; smart00850
317655005169	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655005170	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
317655005171	Transglycosylase; Region: Transgly; cl17702
317655005172	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
317655005173	HSP70 interaction site [polypeptide binding]; other site
317655005174	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
317655005175	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655005176	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
317655005177	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
317655005178	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
317655005179	dimer interface [polypeptide binding]; other site
317655005180	anticodon binding site; other site
317655005181	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
317655005182	homodimer interface [polypeptide binding]; other site
317655005183	motif 1; other site
317655005184	active site
317655005185	motif 2; other site
317655005186	GAD domain; Region: GAD; pfam02938
317655005187	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
317655005188	active site
317655005189	motif 3; other site
317655005190	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
317655005191	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
317655005192	catalytic site [active]
317655005193	putative active site [active]
317655005194	putative substrate binding site [chemical binding]; other site
317655005195	HRDC domain; Region: HRDC; pfam00570
317655005196	exopolyphosphatase; Region: exo_poly_only; TIGR03706
317655005197	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
317655005198	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
317655005199	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
317655005200	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
317655005201	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
317655005202	putative domain interface [polypeptide binding]; other site
317655005203	putative active site [active]
317655005204	catalytic site [active]
317655005205	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
317655005206	putative domain interface [polypeptide binding]; other site
317655005207	putative active site [active]
317655005208	catalytic site [active]
317655005209	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
317655005210	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
317655005211	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
317655005212	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
317655005213	dimerization interface [polypeptide binding]; other site
317655005214	putative ATP binding site [chemical binding]; other site
317655005215	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
317655005216	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
317655005217	active site
317655005218	substrate binding site [chemical binding]; other site
317655005219	cosubstrate binding site; other site
317655005220	catalytic site [active]
317655005221	Protein of unknown function (DUF419); Region: DUF419; pfam04237
317655005222	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
317655005223	active site
317655005224	multimer interface [polypeptide binding]; other site
317655005225	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
317655005226	multifunctional aminopeptidase A; Provisional; Region: PRK00913
317655005227	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
317655005228	interface (dimer of trimers) [polypeptide binding]; other site
317655005229	Substrate-binding/catalytic site; other site
317655005230	Zn-binding sites [ion binding]; other site
317655005231	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
317655005232	OstA-like protein; Region: OstA; cl00844
317655005233	Organic solvent tolerance protein; Region: OstA_C; pfam04453
317655005234	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
317655005235	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655005236	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655005237	acyl-activating enzyme (AAE) consensus motif; other site
317655005238	acyl-activating enzyme (AAE) consensus motif; other site
317655005239	putative AMP binding site [chemical binding]; other site
317655005240	putative active site [active]
317655005241	putative CoA binding site [chemical binding]; other site
317655005242	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
317655005243	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
317655005244	Phosphotransferase enzyme family; Region: APH; pfam01636
317655005245	active site
317655005246	substrate binding site [chemical binding]; other site
317655005247	ATP binding site [chemical binding]; other site
317655005248	Winged helix-turn helix; Region: HTH_29; pfam13551
317655005249	Integrase core domain; Region: rve; pfam00665
317655005250	Integrase core domain; Region: rve_3; pfam13683
317655005251	Transcriptional regulators [Transcription]; Region: MarR; COG1846
317655005252	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
317655005253	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
317655005254	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
317655005255	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
317655005256	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655005257	active site
317655005258	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
317655005259	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
317655005260	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
317655005261	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655005262	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
317655005263	Class I ribonucleotide reductase; Region: RNR_I; cd01679
317655005264	active site
317655005265	dimer interface [polypeptide binding]; other site
317655005266	catalytic residues [active]
317655005267	effector binding site; other site
317655005268	R2 peptide binding site; other site
317655005269	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
317655005270	putative active site [active]
317655005271	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
317655005272	dimer interface [polypeptide binding]; other site
317655005273	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
317655005274	putative radical transfer pathway; other site
317655005275	diiron center [ion binding]; other site
317655005276	tyrosyl radical; other site
317655005277	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
317655005278	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
317655005279	Winged helix-turn helix; Region: HTH_29; pfam13551
317655005280	Integrase core domain; Region: rve; pfam00665
317655005281	Integrase core domain; Region: rve_3; pfam13683
317655005282	Superoxide dismutase [Fe]; Provisional; Region: PTZ00078
317655005283	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
317655005284	hypothetical protein; Provisional; Region: PRK09272
317655005285	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
317655005286	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
317655005287	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655005288	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
317655005289	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
317655005290	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
317655005291	GSH binding site [chemical binding]; other site
317655005292	catalytic residues [active]
317655005293	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
317655005294	active site
317655005295	8-oxo-dGMP binding site [chemical binding]; other site
317655005296	nudix motif; other site
317655005297	metal binding site [ion binding]; metal-binding site
317655005298	Flp/Fap pilin component; Region: Flp_Fap; cl01585
317655005299	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
317655005300	Peptidase family M48; Region: Peptidase_M48; pfam01435
317655005301	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
317655005302	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
317655005303	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
317655005304	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655005305	active site
317655005306	DNA binding site [nucleotide binding]
317655005307	Int/Topo IB signature motif; other site
317655005308	shikimate kinase; Provisional; Region: PRK13946
317655005309	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
317655005310	ADP binding site [chemical binding]; other site
317655005311	magnesium binding site [ion binding]; other site
317655005312	putative shikimate binding site; other site
317655005313	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
317655005314	active site
317655005315	dimer interface [polypeptide binding]; other site
317655005316	metal binding site [ion binding]; metal-binding site
317655005317	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
317655005318	putative hydrophobic ligand binding site [chemical binding]; other site
317655005319	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655005320	dimerization interface [polypeptide binding]; other site
317655005321	putative DNA binding site [nucleotide binding]; other site
317655005322	putative Zn2+ binding site [ion binding]; other site
317655005323	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
317655005324	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
317655005325	TrkA-N domain; Region: TrkA_N; pfam02254
317655005326	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
317655005327	trimerization site [polypeptide binding]; other site
317655005328	active site
317655005329	DNA repair protein RadA; Provisional; Region: PRK11823
317655005330	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655005331	Walker A motif; other site
317655005332	ATP binding site [chemical binding]; other site
317655005333	Walker B motif; other site
317655005334	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
317655005335	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
317655005336	active site
317655005337	intersubunit interactions; other site
317655005338	catalytic residue [active]
317655005339	enoyl-CoA hydratase; Provisional; Region: PRK08252
317655005340	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655005341	substrate binding site [chemical binding]; other site
317655005342	oxyanion hole (OAH) forming residues; other site
317655005343	trimer interface [polypeptide binding]; other site
317655005344	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
317655005345	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
317655005346	active site
317655005347	aldehyde dehydrogenase family 7 member; Region: PLN02315
317655005348	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
317655005349	tetrameric interface [polypeptide binding]; other site
317655005350	NAD binding site [chemical binding]; other site
317655005351	catalytic residues [active]
317655005352	acetyl-CoA synthetase; Provisional; Region: PRK00174
317655005353	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
317655005354	active site
317655005355	CoA binding site [chemical binding]; other site
317655005356	acyl-activating enzyme (AAE) consensus motif; other site
317655005357	AMP binding site [chemical binding]; other site
317655005358	acetate binding site [chemical binding]; other site
317655005359	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
317655005360	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
317655005361	active site
317655005362	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
317655005363	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
317655005364	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
317655005365	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
317655005366	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
317655005367	Uncharacterized conserved protein [Function unknown]; Region: COG2308
317655005368	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
317655005369	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
317655005370	SEC-C motif; Region: SEC-C; pfam02810
317655005371	short chain dehydrogenase; Provisional; Region: PRK08267
317655005372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655005373	NAD(P) binding site [chemical binding]; other site
317655005374	active site
317655005375	CcmB protein; Region: CcmB; cl17444
317655005376	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
317655005377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655005378	Walker A/P-loop; other site
317655005379	ATP binding site [chemical binding]; other site
317655005380	ABC transporter signature motif; other site
317655005381	Walker B; other site
317655005382	D-loop; other site
317655005383	H-loop/switch region; other site
317655005384	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
317655005385	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
317655005386	aromatic arch; other site
317655005387	DCoH dimer interaction site [polypeptide binding]; other site
317655005388	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
317655005389	DCoH tetramer interaction site [polypeptide binding]; other site
317655005390	substrate binding site [chemical binding]; other site
317655005391	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
317655005392	ArsC family; Region: ArsC; pfam03960
317655005393	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
317655005394	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
317655005395	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
317655005396	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
317655005397	HI0933-like protein; Region: HI0933_like; pfam03486
317655005398	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655005399	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
317655005400	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
317655005401	ATP binding site [chemical binding]; other site
317655005402	putative Mg++ binding site [ion binding]; other site
317655005403	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655005404	nucleotide binding region [chemical binding]; other site
317655005405	ATP-binding site [chemical binding]; other site
317655005406	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
317655005407	RNA binding site [nucleotide binding]; other site
317655005408	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
317655005409	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
317655005410	NADP binding site [chemical binding]; other site
317655005411	dimer interface [polypeptide binding]; other site
317655005412	S-formylglutathione hydrolase; Region: PLN02442
317655005413	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
317655005414	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
317655005415	putative deacylase active site [active]
317655005416	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
317655005417	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655005418	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
317655005419	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
317655005420	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
317655005421	putative active site [active]
317655005422	putative substrate binding site [chemical binding]; other site
317655005423	putative cosubstrate binding site; other site
317655005424	catalytic site [active]
317655005425	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
317655005426	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655005427	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
317655005428	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
317655005429	substrate binding site [chemical binding]; other site
317655005430	catalytic Zn binding site [ion binding]; other site
317655005431	NAD binding site [chemical binding]; other site
317655005432	structural Zn binding site [ion binding]; other site
317655005433	dimer interface [polypeptide binding]; other site
317655005434	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655005435	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
317655005436	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655005437	active site
317655005438	threonine dehydratase; Provisional; Region: PRK07334
317655005439	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
317655005440	tetramer interface [polypeptide binding]; other site
317655005441	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655005442	catalytic residue [active]
317655005443	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
317655005444	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
317655005445	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
317655005446	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655005447	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
317655005448	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
317655005449	active site
317655005450	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
317655005451	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
317655005452	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
317655005453	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
317655005454	phosphate binding site [ion binding]; other site
317655005455	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
317655005456	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
317655005457	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
317655005458	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
317655005459	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
317655005460	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655005461	Coenzyme A binding pocket [chemical binding]; other site
317655005462	SnoaL-like domain; Region: SnoaL_4; cl17707
317655005463	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
317655005464	Acyltransferase family; Region: Acyl_transf_3; pfam01757
317655005465	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
317655005466	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
317655005467	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
317655005468	classical (c) SDRs; Region: SDR_c; cd05233
317655005469	NAD(P) binding site [chemical binding]; other site
317655005470	active site
317655005471	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
317655005472	EamA-like transporter family; Region: EamA; pfam00892
317655005473	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655005474	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655005475	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
317655005476	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655005477	putative DNA binding site [nucleotide binding]; other site
317655005478	putative Zn2+ binding site [ion binding]; other site
317655005479	MarR family; Region: MarR_2; cl17246
317655005480	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655005481	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655005482	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
317655005483	active site
317655005484	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
317655005485	Phosphotransferase enzyme family; Region: APH; pfam01636
317655005486	putative active site [active]
317655005487	putative substrate binding site [chemical binding]; other site
317655005488	ATP binding site [chemical binding]; other site
317655005489	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
317655005490	EamA-like transporter family; Region: EamA; pfam00892
317655005491	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
317655005492	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655005493	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
317655005494	putative C-terminal domain interface [polypeptide binding]; other site
317655005495	putative GSH binding site (G-site) [chemical binding]; other site
317655005496	putative dimer interface [polypeptide binding]; other site
317655005497	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
317655005498	N-terminal domain interface [polypeptide binding]; other site
317655005499	dimer interface [polypeptide binding]; other site
317655005500	substrate binding pocket (H-site) [chemical binding]; other site
317655005501	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
317655005502	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655005503	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
317655005504	acyl-activating enzyme (AAE) consensus motif; other site
317655005505	acyl-activating enzyme (AAE) consensus motif; other site
317655005506	putative AMP binding site [chemical binding]; other site
317655005507	putative active site [active]
317655005508	putative CoA binding site [chemical binding]; other site
317655005509	Protein of unknown function (DUF938); Region: DUF938; pfam06080
317655005510	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
317655005511	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655005512	catalytic residue [active]
317655005513	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
317655005514	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
317655005515	tetramer interface [polypeptide binding]; other site
317655005516	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655005517	catalytic residue [active]
317655005518	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
317655005519	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
317655005520	lipoyl attachment site [posttranslational modification]; other site
317655005521	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
317655005522	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
317655005523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655005524	NAD(P) binding site [chemical binding]; other site
317655005525	active site
317655005526	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
317655005527	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
317655005528	Zn2+ binding site [ion binding]; other site
317655005529	Mg2+ binding site [ion binding]; other site
317655005530	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
317655005531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655005532	binding surface
317655005533	TPR motif; other site
317655005534	Sporulation related domain; Region: SPOR; cl10051
317655005535	cell division protein FtsZ; Validated; Region: PRK09330
317655005536	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
317655005537	nucleotide binding site [chemical binding]; other site
317655005538	SulA interaction site; other site
317655005539	cell division protein FtsA; Region: ftsA; TIGR01174
317655005540	Cell division protein FtsA; Region: FtsA; smart00842
317655005541	Cell division protein FtsA; Region: FtsA; pfam14450
317655005542	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
317655005543	Cell division protein FtsQ; Region: FtsQ; pfam03799
317655005544	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
317655005545	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
317655005546	ATP-grasp domain; Region: ATP-grasp_4; cl17255
317655005547	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
317655005548	FAD binding domain; Region: FAD_binding_4; pfam01565
317655005549	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
317655005550	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
317655005551	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
317655005552	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
317655005553	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
317655005554	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
317655005555	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
317655005556	active site
317655005557	homodimer interface [polypeptide binding]; other site
317655005558	cell division protein FtsW; Region: ftsW; TIGR02614
317655005559	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
317655005560	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
317655005561	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
317655005562	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
317655005563	Mg++ binding site [ion binding]; other site
317655005564	putative catalytic motif [active]
317655005565	putative substrate binding site [chemical binding]; other site
317655005566	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
317655005567	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
317655005568	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
317655005569	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
317655005570	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
317655005571	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
317655005572	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
317655005573	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
317655005574	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
317655005575	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
317655005576	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
317655005577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655005578	S-adenosylmethionine binding site [chemical binding]; other site
317655005579	cell division protein MraZ; Reviewed; Region: PRK00326
317655005580	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
317655005581	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
317655005582	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
317655005583	dimer interface [polypeptide binding]; other site
317655005584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655005585	catalytic residue [active]
317655005586	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655005587	N-terminal plug; other site
317655005588	ligand-binding site [chemical binding]; other site
317655005589	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655005590	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
317655005591	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655005592	NAD(P) binding site [chemical binding]; other site
317655005593	active site
317655005594	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
317655005595	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
317655005596	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
317655005597	dimer interface [polypeptide binding]; other site
317655005598	catalytic triad [active]
317655005599	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
317655005600	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
317655005601	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
317655005602	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
317655005603	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
317655005604	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
317655005605	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
317655005606	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
317655005607	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
317655005608	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655005609	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
317655005610	dimerization interface [polypeptide binding]; other site
317655005611	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655005612	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
317655005613	Sel1-like repeats; Region: SEL1; smart00671
317655005614	Sporulation related domain; Region: SPOR; pfam05036
317655005615	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
317655005616	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
317655005617	P-loop; other site
317655005618	Magnesium ion binding site [ion binding]; other site
317655005619	Sporulation related domain; Region: SPOR; pfam05036
317655005620	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
317655005621	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
317655005622	GTP cyclohydrolase I; Provisional; Region: PLN03044
317655005623	active site
317655005624	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655005625	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655005626	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655005627	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655005628	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655005629	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655005630	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655005631	Maf-like protein; Region: Maf; pfam02545
317655005632	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
317655005633	active site
317655005634	dimer interface [polypeptide binding]; other site
317655005635	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
317655005636	rRNA binding site [nucleotide binding]; other site
317655005637	predicted 30S ribosome binding site; other site
317655005638	Cupin-like domain; Region: Cupin_8; pfam13621
317655005639	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
317655005640	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
317655005641	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
317655005642	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
317655005643	active site
317655005644	dimer interface [polypeptide binding]; other site
317655005645	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
317655005646	Ligand Binding Site [chemical binding]; other site
317655005647	Molecular Tunnel; other site
317655005648	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
317655005649	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
317655005650	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
317655005651	EpsI family protein; Region: EpsI_fam; TIGR02914
317655005652	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
317655005653	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
317655005654	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
317655005655	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
317655005656	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
317655005657	putative active site [active]
317655005658	putative catalytic site [active]
317655005659	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
317655005660	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655005661	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
317655005662	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
317655005663	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
317655005664	Chain length determinant protein; Region: Wzz; cl15801
317655005665	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
317655005666	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
317655005667	SLBB domain; Region: SLBB; pfam10531
317655005668	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
317655005669	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
317655005670	dimer interface [polypeptide binding]; other site
317655005671	active site
317655005672	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655005673	catalytic residues [active]
317655005674	substrate binding site [chemical binding]; other site
317655005675	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
317655005676	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655005677	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
317655005678	acyl-activating enzyme (AAE) consensus motif; other site
317655005679	acyl-activating enzyme (AAE) consensus motif; other site
317655005680	AMP binding site [chemical binding]; other site
317655005681	active site
317655005682	CoA binding site [chemical binding]; other site
317655005683	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
317655005684	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
317655005685	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
317655005686	malate synthase G; Provisional; Region: PRK02999
317655005687	active site
317655005688	WYL domain; Region: WYL; cl14852
317655005689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655005690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655005691	metal binding site [ion binding]; metal-binding site
317655005692	active site
317655005693	I-site; other site
317655005694	hypothetical protein; Provisional; Region: PRK07338
317655005695	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
317655005696	metal binding site [ion binding]; metal-binding site
317655005697	dimer interface [polypeptide binding]; other site
317655005698	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
317655005699	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
317655005700	succinylarginine dihydrolase; Provisional; Region: PRK13281
317655005701	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655005702	poly(3-hydroxyalkanoate) depolymerase; Region: PHA_depoly_arom; TIGR02240
317655005703	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
317655005704	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
317655005705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655005706	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
317655005707	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
317655005708	ATP binding site [chemical binding]; other site
317655005709	Mg++ binding site [ion binding]; other site
317655005710	motif III; other site
317655005711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655005712	nucleotide binding region [chemical binding]; other site
317655005713	ATP-binding site [chemical binding]; other site
317655005714	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
317655005715	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
317655005716	N- and C-terminal domain interface [polypeptide binding]; other site
317655005717	active site
317655005718	MgATP binding site [chemical binding]; other site
317655005719	catalytic site [active]
317655005720	metal binding site [ion binding]; metal-binding site
317655005721	glycerol binding site [chemical binding]; other site
317655005722	homotetramer interface [polypeptide binding]; other site
317655005723	homodimer interface [polypeptide binding]; other site
317655005724	FBP binding site [chemical binding]; other site
317655005725	protein IIAGlc interface [polypeptide binding]; other site
317655005726	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
317655005727	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
317655005728	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
317655005729	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
317655005730	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
317655005731	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
317655005732	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
317655005733	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
317655005734	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
317655005735	Surface antigen; Region: Bac_surface_Ag; pfam01103
317655005736	Surface antigen; Region: Bac_surface_Ag; pfam01103
317655005737	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
317655005738	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
317655005739	active site
317655005740	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
317655005741	protein binding site [polypeptide binding]; other site
317655005742	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
317655005743	putative substrate binding region [chemical binding]; other site
317655005744	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
317655005745	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
317655005746	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
317655005747	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
317655005748	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
317655005749	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
317655005750	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
317655005751	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
317655005752	catalytic residue [active]
317655005753	putative FPP diphosphate  binding site; other site
317655005754	putative FPP binding hydrophobic cleft; other site
317655005755	dimer interface [polypeptide binding]; other site
317655005756	putative IPP diphosphate binding site; other site
317655005757	ribosome recycling factor; Reviewed; Region: frr; PRK00083
317655005758	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
317655005759	hinge region; other site
317655005760	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
317655005761	putative nucleotide binding site [chemical binding]; other site
317655005762	uridine monophosphate binding site [chemical binding]; other site
317655005763	homohexameric interface [polypeptide binding]; other site
317655005764	elongation factor Ts; Provisional; Region: tsf; PRK09377
317655005765	UBA/TS-N domain; Region: UBA; pfam00627
317655005766	Elongation factor TS; Region: EF_TS; pfam00889
317655005767	Elongation factor TS; Region: EF_TS; pfam00889
317655005768	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
317655005769	rRNA interaction site [nucleotide binding]; other site
317655005770	S8 interaction site; other site
317655005771	putative laminin-1 binding site; other site
317655005772	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
317655005773	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
317655005774	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
317655005775	isocitrate dehydrogenase; Validated; Region: PRK08299
317655005776	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
317655005777	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
317655005778	TrkA-N domain; Region: TrkA_N; pfam02254
317655005779	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655005780	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
317655005781	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655005782	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655005783	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655005784	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
317655005785	nitrilase; Region: PLN02798
317655005786	putative active site [active]
317655005787	catalytic triad [active]
317655005788	dimer interface [polypeptide binding]; other site
317655005789	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
317655005790	nudix motif; other site
317655005791	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
317655005792	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
317655005793	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655005794	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655005795	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
317655005796	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
317655005797	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
317655005798	NAD binding site [chemical binding]; other site
317655005799	Phe binding site; other site
317655005800	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655005801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655005802	putative DNA binding site [nucleotide binding]; other site
317655005803	putative Zn2+ binding site [ion binding]; other site
317655005804	AsnC family; Region: AsnC_trans_reg; pfam01037
317655005805	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
317655005806	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
317655005807	active site
317655005808	Uncharacterized conserved protein [Function unknown]; Region: COG3339
317655005809	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
317655005810	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655005811	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
317655005812	GAF domain; Region: GAF_2; pfam13185
317655005813	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
317655005814	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
317655005815	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
317655005816	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
317655005817	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
317655005818	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
317655005819	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655005820	Walker A/P-loop; other site
317655005821	ATP binding site [chemical binding]; other site
317655005822	Q-loop/lid; other site
317655005823	ABC transporter signature motif; other site
317655005824	Walker B; other site
317655005825	D-loop; other site
317655005826	H-loop/switch region; other site
317655005827	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
317655005828	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
317655005829	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
317655005830	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
317655005831	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
317655005832	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655005833	ligand binding site [chemical binding]; other site
317655005834	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
317655005835	Putative phage tail protein; Region: Phage-tail_3; pfam13550
317655005836	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
317655005837	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
317655005838	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
317655005839	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
317655005840	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
317655005841	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
317655005842	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
317655005843	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
317655005844	Phage capsid family; Region: Phage_capsid; pfam05065
317655005845	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
317655005846	Phage-related protein [Function unknown]; Region: COG4695
317655005847	Phage portal protein; Region: Phage_portal; pfam04860
317655005848	Uncharacterized conserved protein [Function unknown]; Region: COG1432
317655005849	LabA_like proteins; Region: LabA_like; cd06167
317655005850	putative metal binding site [ion binding]; other site
317655005851	Uncharacterized conserved protein [Function unknown]; Region: COG5323
317655005852	Terminase-like family; Region: Terminase_6; pfam03237
317655005853	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
317655005854	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655005855	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
317655005856	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655005857	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
317655005858	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655005859	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655005860	active site
317655005861	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
317655005862	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
317655005863	active site
317655005864	purine riboside binding site [chemical binding]; other site
317655005865	rod shape-determining protein MreB; Provisional; Region: PRK13927
317655005866	MreB and similar proteins; Region: MreB_like; cd10225
317655005867	nucleotide binding site [chemical binding]; other site
317655005868	Mg binding site [ion binding]; other site
317655005869	putative protofilament interaction site [polypeptide binding]; other site
317655005870	RodZ interaction site [polypeptide binding]; other site
317655005871	putative diguanylate cyclase; Provisional; Region: PRK09776
317655005872	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
317655005873	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
317655005874	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
317655005875	active site
317655005876	HIGH motif; other site
317655005877	dimer interface [polypeptide binding]; other site
317655005878	KMSKS motif; other site
317655005879	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
317655005880	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
317655005881	Preprotein translocase subunit SecB; Region: SecB; pfam02556
317655005882	SecA binding site; other site
317655005883	Preprotein binding site; other site
317655005884	Tim44-like domain; Region: Tim44; pfam04280
317655005885	MltA specific insert domain; Region: MltA; smart00925
317655005886	3D domain; Region: 3D; pfam06725
317655005887	Smr domain; Region: Smr; pfam01713
317655005888	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
317655005889	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
317655005890	metal binding site [ion binding]; metal-binding site
317655005891	dimer interface [polypeptide binding]; other site
317655005892	Cupin domain; Region: Cupin_2; cl17218
317655005893	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655005894	Cytochrome P450; Region: p450; cl12078
317655005895	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
317655005896	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
317655005897	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
317655005898	thiamine-monophosphate kinase; Region: thiL; TIGR01379
317655005899	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
317655005900	ATP binding site [chemical binding]; other site
317655005901	dimerization interface [polypeptide binding]; other site
317655005902	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
317655005903	histidinol dehydrogenase; Region: hisD; TIGR00069
317655005904	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
317655005905	NAD binding site [chemical binding]; other site
317655005906	dimerization interface [polypeptide binding]; other site
317655005907	product binding site; other site
317655005908	substrate binding site [chemical binding]; other site
317655005909	zinc binding site [ion binding]; other site
317655005910	catalytic residues [active]
317655005911	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
317655005912	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
317655005913	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
317655005914	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
317655005915	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
317655005916	Ligand Binding Site [chemical binding]; other site
317655005917	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
317655005918	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655005919	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655005920	GTP-binding protein LepA; Provisional; Region: PRK05433
317655005921	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
317655005922	G1 box; other site
317655005923	putative GEF interaction site [polypeptide binding]; other site
317655005924	GTP/Mg2+ binding site [chemical binding]; other site
317655005925	Switch I region; other site
317655005926	G2 box; other site
317655005927	G3 box; other site
317655005928	Switch II region; other site
317655005929	G4 box; other site
317655005930	G5 box; other site
317655005931	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
317655005932	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
317655005933	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
317655005934	SnoaL-like domain; Region: SnoaL_2; pfam12680
317655005935	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
317655005936	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
317655005937	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655005938	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655005939	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
317655005940	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
317655005941	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
317655005942	active site
317655005943	substrate-binding site [chemical binding]; other site
317655005944	metal-binding site [ion binding]
317655005945	ATP binding site [chemical binding]; other site
317655005946	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
317655005947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655005948	active site
317655005949	phosphorylation site [posttranslational modification]
317655005950	intermolecular recognition site; other site
317655005951	dimerization interface [polypeptide binding]; other site
317655005952	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
317655005953	DNA binding site [nucleotide binding]
317655005954	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
317655005955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655005956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655005957	dimer interface [polypeptide binding]; other site
317655005958	phosphorylation site [posttranslational modification]
317655005959	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655005960	ATP binding site [chemical binding]; other site
317655005961	Mg2+ binding site [ion binding]; other site
317655005962	G-X-G motif; other site
317655005963	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
317655005964	Hpr binding site; other site
317655005965	active site
317655005966	homohexamer subunit interaction site [polypeptide binding]; other site
317655005967	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
317655005968	shikimate kinase; Reviewed; Region: aroK; PRK00131
317655005969	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
317655005970	active pocket/dimerization site; other site
317655005971	active site
317655005972	phosphorylation site [posttranslational modification]
317655005973	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
317655005974	dimerization domain swap beta strand [polypeptide binding]; other site
317655005975	regulatory protein interface [polypeptide binding]; other site
317655005976	active site
317655005977	regulatory phosphorylation site [posttranslational modification]; other site
317655005978	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
317655005979	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
317655005980	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
317655005981	Predicted membrane protein [Function unknown]; Region: COG3650
317655005982	META domain; Region: META; pfam03724
317655005983	RmuC family; Region: RmuC; pfam02646
317655005984	Protein of unknown function (DUF461); Region: DUF461; pfam04314
317655005985	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
317655005986	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
317655005987	nucleotide binding site [chemical binding]; other site
317655005988	NEF interaction site [polypeptide binding]; other site
317655005989	SBD interface [polypeptide binding]; other site
317655005990	chaperone protein DnaJ; Provisional; Region: PRK10767
317655005991	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
317655005992	HSP70 interaction site [polypeptide binding]; other site
317655005993	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
317655005994	substrate binding site [polypeptide binding]; other site
317655005995	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
317655005996	Zn binding sites [ion binding]; other site
317655005997	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
317655005998	dimer interface [polypeptide binding]; other site
317655005999	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
317655006000	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655006001	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
317655006002	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
317655006003	Uncharacterized conserved protein [Function unknown]; Region: COG2128
317655006004	Predicted membrane protein [Function unknown]; Region: COG2259
317655006005	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
317655006006	PhoH-like protein; Region: PhoH; pfam02562
317655006007	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
317655006008	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
317655006009	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655006010	FeS/SAM binding site; other site
317655006011	TRAM domain; Region: TRAM; cl01282
317655006012	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
317655006013	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
317655006014	putative acyl-acceptor binding pocket; other site
317655006015	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
317655006016	metal binding site 2 [ion binding]; metal-binding site
317655006017	putative DNA binding helix; other site
317655006018	metal binding site 1 [ion binding]; metal-binding site
317655006019	dimer interface [polypeptide binding]; other site
317655006020	structural Zn2+ binding site [ion binding]; other site
317655006021	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
317655006022	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
317655006023	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655006024	Coenzyme A binding pocket [chemical binding]; other site
317655006025	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
317655006026	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
317655006027	putative FMN binding site [chemical binding]; other site
317655006028	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
317655006029	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
317655006030	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655006031	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
317655006032	putative dimer interface [polypeptide binding]; other site
317655006033	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655006034	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
317655006035	putative dimer interface [polypeptide binding]; other site
317655006036	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
317655006037	Usg-like family; Region: Usg; pfam06233
317655006038	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
317655006039	oligomerisation interface [polypeptide binding]; other site
317655006040	mobile loop; other site
317655006041	roof hairpin; other site
317655006042	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
317655006043	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
317655006044	ring oligomerisation interface [polypeptide binding]; other site
317655006045	ATP/Mg binding site [chemical binding]; other site
317655006046	stacking interactions; other site
317655006047	hinge regions; other site
317655006048	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
317655006049	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
317655006050	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
317655006051	putative catalytic residue [active]
317655006052	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
317655006053	HlyD family secretion protein; Region: HlyD; pfam00529
317655006054	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655006055	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
317655006056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655006057	putative substrate translocation pore; other site
317655006058	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
317655006059	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
317655006060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655006061	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
317655006062	Predicted transcriptional regulator [Transcription]; Region: COG2944
317655006063	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655006064	non-specific DNA binding site [nucleotide binding]; other site
317655006065	salt bridge; other site
317655006066	sequence-specific DNA binding site [nucleotide binding]; other site
317655006067	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655006068	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
317655006069	C-terminal domain interface [polypeptide binding]; other site
317655006070	GSH binding site (G-site) [chemical binding]; other site
317655006071	dimer interface [polypeptide binding]; other site
317655006072	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
317655006073	N-terminal domain interface [polypeptide binding]; other site
317655006074	dimer interface [polypeptide binding]; other site
317655006075	substrate binding pocket (H-site) [chemical binding]; other site
317655006076	CHASE domain; Region: CHASE; pfam03924
317655006077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
317655006078	HWE histidine kinase; Region: HWE_HK; smart00911
317655006079	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655006080	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655006081	DNA binding site [nucleotide binding]
317655006082	domain linker motif; other site
317655006083	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
317655006084	putative dimerization interface [polypeptide binding]; other site
317655006085	putative ligand binding site [chemical binding]; other site
317655006086	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
317655006087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655006088	N-terminal plug; other site
317655006089	ligand-binding site [chemical binding]; other site
317655006090	Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505
317655006091	aconitate hydratase; Validated; Region: PRK09277
317655006092	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
317655006093	substrate binding site [chemical binding]; other site
317655006094	ligand binding site [chemical binding]; other site
317655006095	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
317655006096	substrate binding site [chemical binding]; other site
317655006097	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
317655006098	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
317655006099	oligomer interface [polypeptide binding]; other site
317655006100	metal binding site [ion binding]; metal-binding site
317655006101	metal binding site [ion binding]; metal-binding site
317655006102	putative Cl binding site [ion binding]; other site
317655006103	basic sphincter; other site
317655006104	hydrophobic gate; other site
317655006105	periplasmic entrance; other site
317655006106	MarR family; Region: MarR_2; cl17246
317655006107	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
317655006108	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
317655006109	Catalytic site; other site
317655006110	camphor resistance protein CrcB; Provisional; Region: PRK14195
317655006111	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
317655006112	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
317655006113	active site
317655006114	ATP12 chaperone protein; Region: ATP12; pfam07542
317655006115	Transposase domain (DUF772); Region: DUF772; pfam05598
317655006116	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655006117	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
317655006118	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
317655006119	putative active site [active]
317655006120	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
317655006121	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
317655006122	CAP-like domain; other site
317655006123	active site
317655006124	primary dimer interface [polypeptide binding]; other site
317655006125	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655006126	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655006127	metal binding site [ion binding]; metal-binding site
317655006128	active site
317655006129	I-site; other site
317655006130	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655006131	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
317655006132	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
317655006133	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
317655006134	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
317655006135	putative active site [active]
317655006136	putative CoA binding site [chemical binding]; other site
317655006137	nudix motif; other site
317655006138	metal binding site [ion binding]; metal-binding site
317655006139	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
317655006140	Predicted acetyltransferase [General function prediction only]; Region: COG3153
317655006141	Dihydroneopterin aldolase; Region: FolB; smart00905
317655006142	short chain dehydrogenase; Provisional; Region: PRK09134
317655006143	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655006144	NAD(P) binding site [chemical binding]; other site
317655006145	active site
317655006146	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655006147	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
317655006148	tetramerization interface [polypeptide binding]; other site
317655006149	NAD(P) binding site [chemical binding]; other site
317655006150	catalytic residues [active]
317655006151	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
317655006152	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
317655006153	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
317655006154	Protein of unknown function (DUF2855); Region: DUF2855; pfam11017
317655006155	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
317655006156	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655006157	motif II; other site
317655006158	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655006159	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655006160	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
317655006161	dimerization interface [polypeptide binding]; other site
317655006162	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
317655006163	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
317655006164	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655006165	extended (e) SDRs; Region: SDR_e; cd08946
317655006166	NAD(P) binding site [chemical binding]; other site
317655006167	active site
317655006168	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
317655006169	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655006170	putative C-terminal domain interface [polypeptide binding]; other site
317655006171	putative GSH binding site (G-site) [chemical binding]; other site
317655006172	putative dimer interface [polypeptide binding]; other site
317655006173	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
317655006174	putative N-terminal domain interface [polypeptide binding]; other site
317655006175	putative dimer interface [polypeptide binding]; other site
317655006176	putative substrate binding pocket (H-site) [chemical binding]; other site
317655006177	beta-carotene hydroxylase; Region: PLN02601
317655006178	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
317655006179	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
317655006180	substrate binding site [chemical binding]; other site
317655006181	ligand binding site [chemical binding]; other site
317655006182	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655006183	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
317655006184	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
317655006185	substrate binding site [chemical binding]; other site
317655006186	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
317655006187	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
317655006188	NAD(P) binding site [chemical binding]; other site
317655006189	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
317655006190	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
317655006191	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
317655006192	putative NAD(P) binding site [chemical binding]; other site
317655006193	active site
317655006194	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
317655006195	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
317655006196	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
317655006197	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655006198	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
317655006199	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
317655006200	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
317655006201	active site
317655006202	dimer interface [polypeptide binding]; other site
317655006203	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
317655006204	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
317655006205	active site
317655006206	FMN binding site [chemical binding]; other site
317655006207	substrate binding site [chemical binding]; other site
317655006208	3Fe-4S cluster binding site [ion binding]; other site
317655006209	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
317655006210	domain interface; other site
317655006211	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655006212	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
317655006213	C-terminal domain interface [polypeptide binding]; other site
317655006214	GSH binding site (G-site) [chemical binding]; other site
317655006215	dimer interface [polypeptide binding]; other site
317655006216	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
317655006217	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655006218	S-adenosylmethionine binding site [chemical binding]; other site
317655006219	aspartate kinase; Reviewed; Region: PRK06635
317655006220	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
317655006221	putative nucleotide binding site [chemical binding]; other site
317655006222	putative catalytic residues [active]
317655006223	putative Mg ion binding site [ion binding]; other site
317655006224	putative aspartate binding site [chemical binding]; other site
317655006225	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
317655006226	putative allosteric regulatory site; other site
317655006227	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
317655006228	putative allosteric regulatory residue; other site
317655006229	Intracellular septation protein A; Region: IspA; cl01098
317655006230	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
317655006231	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
317655006232	heme binding site [chemical binding]; other site
317655006233	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
317655006234	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
317655006235	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
317655006236	FMN binding site [chemical binding]; other site
317655006237	substrate binding site [chemical binding]; other site
317655006238	putative catalytic residue [active]
317655006239	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
317655006240	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
317655006241	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
317655006242	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
317655006243	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
317655006244	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
317655006245	active site
317655006246	Uncharacterized conserved protein [Function unknown]; Region: COG3791
317655006247	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655006248	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655006249	recombination factor protein RarA; Reviewed; Region: PRK13342
317655006250	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655006251	Walker A motif; other site
317655006252	ATP binding site [chemical binding]; other site
317655006253	Walker B motif; other site
317655006254	arginine finger; other site
317655006255	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
317655006256	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
317655006257	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
317655006258	FOG: CBS domain [General function prediction only]; Region: COG0517
317655006259	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
317655006260	Transporter associated domain; Region: CorC_HlyC; smart01091
317655006261	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
317655006262	Mechanosensitive ion channel; Region: MS_channel; pfam00924
317655006263	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
317655006264	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
317655006265	putative active site [active]
317655006266	putative catalytic site [active]
317655006267	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
317655006268	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655006269	dimer interface [polypeptide binding]; other site
317655006270	active site
317655006271	Uncharacterized conserved protein [Function unknown]; Region: COG2128
317655006272	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
317655006273	Uncharacterized conserved protein [Function unknown]; Region: COG1359
317655006274	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
317655006275	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
317655006276	DNA binding residues [nucleotide binding]
317655006277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655006278	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
317655006279	active site
317655006280	metal binding site [ion binding]; metal-binding site
317655006281	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
317655006282	Transposase domain (DUF772); Region: DUF772; pfam05598
317655006283	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655006284	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
317655006285	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
317655006286	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
317655006287	substrate-cofactor binding pocket; other site
317655006288	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655006289	catalytic residue [active]
317655006290	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655006291	dimer interface [polypeptide binding]; other site
317655006292	phosphorylation site [posttranslational modification]
317655006293	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655006294	ATP binding site [chemical binding]; other site
317655006295	Mg2+ binding site [ion binding]; other site
317655006296	G-X-G motif; other site
317655006297	Response regulator receiver domain; Region: Response_reg; pfam00072
317655006298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655006299	active site
317655006300	phosphorylation site [posttranslational modification]
317655006301	intermolecular recognition site; other site
317655006302	dimerization interface [polypeptide binding]; other site
317655006303	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
317655006304	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
317655006305	Predicted permeases [General function prediction only]; Region: COG0795
317655006306	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
317655006307	Predicted permeases [General function prediction only]; Region: COG0795
317655006308	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
317655006309	Fatty acid desaturase; Region: FA_desaturase; pfam00487
317655006310	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060
317655006311	putative di-iron ligands [ion binding]; other site
317655006312	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
317655006313	putative acetyltransferase; Provisional; Region: PRK03624
317655006314	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
317655006315	putative catalytic site [active]
317655006316	putative phosphate binding site [ion binding]; other site
317655006317	active site
317655006318	metal binding site A [ion binding]; metal-binding site
317655006319	DNA binding site [nucleotide binding]
317655006320	putative AP binding site [nucleotide binding]; other site
317655006321	putative metal binding site B [ion binding]; other site
317655006322	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
317655006323	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
317655006324	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655006325	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
317655006326	dinuclear metal binding motif [ion binding]; other site
317655006327	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
317655006328	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
317655006329	catalytic triad [active]
317655006330	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
317655006331	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
317655006332	metal binding triad; other site
317655006333	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
317655006334	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
317655006335	metal binding triad; other site
317655006336	two-component response regulator; Provisional; Region: PRK09191
317655006337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655006338	active site
317655006339	phosphorylation site [posttranslational modification]
317655006340	intermolecular recognition site; other site
317655006341	dimerization interface [polypeptide binding]; other site
317655006342	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
317655006343	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
317655006344	Hemerythrin-like domain; Region: Hr-like; cd12108
317655006345	Fe binding site [ion binding]; other site
317655006346	PAS domain; Region: PAS_9; pfam13426
317655006347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655006348	putative active site [active]
317655006349	heme pocket [chemical binding]; other site
317655006350	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655006351	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655006352	metal binding site [ion binding]; metal-binding site
317655006353	active site
317655006354	I-site; other site
317655006355	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655006356	PilZ domain; Region: PilZ; pfam07238
317655006357	PilZ domain; Region: PilZ; pfam07238
317655006358	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655006359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655006360	non-specific DNA binding site [nucleotide binding]; other site
317655006361	salt bridge; other site
317655006362	sequence-specific DNA binding site [nucleotide binding]; other site
317655006363	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
317655006364	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
317655006365	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
317655006366	active site
317655006367	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
317655006368	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
317655006369	active site
317655006370	(T/H)XGH motif; other site
317655006371	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
317655006372	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
317655006373	substrate binding pocket [chemical binding]; other site
317655006374	chain length determination region; other site
317655006375	substrate-Mg2+ binding site; other site
317655006376	catalytic residues [active]
317655006377	aspartate-rich region 1; other site
317655006378	active site lid residues [active]
317655006379	aspartate-rich region 2; other site
317655006380	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
317655006381	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
317655006382	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
317655006383	dimerization interface [polypeptide binding]; other site
317655006384	ATP binding site [chemical binding]; other site
317655006385	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
317655006386	dimerization interface [polypeptide binding]; other site
317655006387	ATP binding site [chemical binding]; other site
317655006388	Protein of unknown function DUF72; Region: DUF72; pfam01904
317655006389	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
317655006390	Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney,  using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144
317655006391	putative FMN binding site [chemical binding]; other site
317655006392	putative dimer interface [polypeptide binding]; other site
317655006393	Predicted membrane protein [Function unknown]; Region: COG2311
317655006394	Protein of unknown function (DUF418); Region: DUF418; cl12135
317655006395	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
317655006396	putative binding surface; other site
317655006397	active site
317655006398	GTP-binding protein Der; Reviewed; Region: PRK00093
317655006399	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
317655006400	G1 box; other site
317655006401	GTP/Mg2+ binding site [chemical binding]; other site
317655006402	Switch I region; other site
317655006403	G2 box; other site
317655006404	Switch II region; other site
317655006405	G3 box; other site
317655006406	G4 box; other site
317655006407	G5 box; other site
317655006408	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
317655006409	G1 box; other site
317655006410	GTP/Mg2+ binding site [chemical binding]; other site
317655006411	Switch I region; other site
317655006412	G2 box; other site
317655006413	G3 box; other site
317655006414	Switch II region; other site
317655006415	G4 box; other site
317655006416	G5 box; other site
317655006417	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
317655006418	Trp docking motif [polypeptide binding]; other site
317655006419	active site
317655006420	PQQ-like domain; Region: PQQ_2; pfam13360
317655006421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
317655006422	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
317655006423	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
317655006424	oligomerization interface [polypeptide binding]; other site
317655006425	active site
317655006426	metal binding site [ion binding]; metal-binding site
317655006427	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
317655006428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
317655006429	non-specific DNA binding site [nucleotide binding]; other site
317655006430	salt bridge; other site
317655006431	sequence-specific DNA binding site [nucleotide binding]; other site
317655006432	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
317655006433	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
317655006434	putative active site [active]
317655006435	catalytic site [active]
317655006436	putative metal binding site [ion binding]; other site
317655006437	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
317655006438	ArsC family; Region: ArsC; pfam03960
317655006439	putative catalytic residues [active]
317655006440	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655006441	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655006442	ligand binding site [chemical binding]; other site
317655006443	flexible hinge region; other site
317655006444	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
317655006445	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
317655006446	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
317655006447	PA/protease or protease-like domain interface [polypeptide binding]; other site
317655006448	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
317655006449	Peptidase family M28; Region: Peptidase_M28; pfam04389
317655006450	metal binding site [ion binding]; metal-binding site
317655006451	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
317655006452	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
317655006453	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
317655006454	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
317655006455	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
317655006456	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
317655006457	gamma-glutamyl kinase; Provisional; Region: PRK05429
317655006458	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
317655006459	nucleotide binding site [chemical binding]; other site
317655006460	substrate binding site [chemical binding]; other site
317655006461	PUA domain; Region: PUA; cl00607
317655006462	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655006463	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655006464	NAD(P) binding site [chemical binding]; other site
317655006465	active site
317655006466	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
317655006467	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
317655006468	tandem repeat interface [polypeptide binding]; other site
317655006469	oligomer interface [polypeptide binding]; other site
317655006470	active site residues [active]
317655006471	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
317655006472	tandem repeat interface [polypeptide binding]; other site
317655006473	oligomer interface [polypeptide binding]; other site
317655006474	active site residues [active]
317655006475	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
317655006476	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
317655006477	Predicted membrane protein [Function unknown]; Region: COG2860
317655006478	UPF0126 domain; Region: UPF0126; pfam03458
317655006479	UPF0126 domain; Region: UPF0126; pfam03458
317655006480	Uncharacterized conserved protein [Function unknown]; Region: COG3791
317655006481	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06115
317655006482	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
317655006483	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655006484	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655006485	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448
317655006486	GIY-YIG motif/motif A; other site
317655006487	putative active site [active]
317655006488	putative metal binding site [ion binding]; other site
317655006489	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
317655006490	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
317655006491	E3 interaction surface; other site
317655006492	lipoyl attachment site [posttranslational modification]; other site
317655006493	e3 binding domain; Region: E3_binding; pfam02817
317655006494	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
317655006495	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
317655006496	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
317655006497	TPP-binding site [chemical binding]; other site
317655006498	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
317655006499	dimer interface [polypeptide binding]; other site
317655006500	PYR/PP interface [polypeptide binding]; other site
317655006501	TPP binding site [chemical binding]; other site
317655006502	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
317655006503	CoA binding domain; Region: CoA_binding; smart00881
317655006504	CoA-ligase; Region: Ligase_CoA; pfam00549
317655006505	malate dehydrogenase; Reviewed; Region: PRK06223
317655006506	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
317655006507	NAD(P) binding site [chemical binding]; other site
317655006508	dimer interface [polypeptide binding]; other site
317655006509	tetramer (dimer of dimers) interface [polypeptide binding]; other site
317655006510	substrate binding site [chemical binding]; other site
317655006511	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u9; cd10933
317655006512	putative active site [active]
317655006513	putative catalytic site [active]
317655006514	Predicted ATPase [General function prediction only]; Region: COG1485
317655006515	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
317655006516	CoenzymeA binding site [chemical binding]; other site
317655006517	subunit interaction site [polypeptide binding]; other site
317655006518	PHB binding site; other site
317655006519	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
317655006520	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
317655006521	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
317655006522	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
317655006523	Nucleopolyhedrovirus protein of unknown function (DUF918); Region: DUF918; pfam06033
317655006524	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
317655006525	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
317655006526	HIT family signature motif; other site
317655006527	catalytic residue [active]
317655006528	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
317655006529	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
317655006530	active site
317655006531	metal-binding site
317655006532	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
317655006533	active site
317655006534	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
317655006535	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
317655006536	substrate binding pocket [chemical binding]; other site
317655006537	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655006538	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
317655006539	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
317655006540	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
317655006541	putative active site [active]
317655006542	putative metal binding site [ion binding]; other site
317655006543	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
317655006544	Ecdysteroid kinase; Region: EcKinase; cl17738
317655006545	Phosphotransferase enzyme family; Region: APH; pfam01636
317655006546	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
317655006547	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
317655006548	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
317655006549	protein binding site [polypeptide binding]; other site
317655006550	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
317655006551	protein binding site [polypeptide binding]; other site
317655006552	HflC protein; Region: hflC; TIGR01932
317655006553	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
317655006554	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
317655006555	HflK protein; Region: hflK; TIGR01933
317655006556	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
317655006557	Walker A motif; other site
317655006558	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
317655006559	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
317655006560	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
317655006561	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
317655006562	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
317655006563	ferrochelatase; Reviewed; Region: hemH; PRK00035
317655006564	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
317655006565	active site
317655006566	C-terminal domain interface [polypeptide binding]; other site
317655006567	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
317655006568	active site
317655006569	N-terminal domain interface [polypeptide binding]; other site
317655006570	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
317655006571	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
317655006572	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
317655006573	NAD(P) binding site [chemical binding]; other site
317655006574	homotetramer interface [polypeptide binding]; other site
317655006575	homodimer interface [polypeptide binding]; other site
317655006576	active site
317655006577	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
317655006578	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
317655006579	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
317655006580	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655006581	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655006582	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
317655006583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
317655006584	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
317655006585	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
317655006586	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
317655006587	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
317655006588	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
317655006589	putative NADH binding site [chemical binding]; other site
317655006590	putative active site [active]
317655006591	nudix motif; other site
317655006592	putative metal binding site [ion binding]; other site
317655006593	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655006594	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655006595	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
317655006596	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
317655006597	minor groove reading motif; other site
317655006598	helix-hairpin-helix signature motif; other site
317655006599	substrate binding pocket [chemical binding]; other site
317655006600	active site
317655006601	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
317655006602	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
317655006603	DNA binding and oxoG recognition site [nucleotide binding]
317655006604	Protein of unknown function (DUF721); Region: DUF721; pfam05258
317655006605	Thioredoxin; Region: Thioredoxin_4; pfam13462
317655006606	Thioredoxin; Region: Thioredoxin_4; cl17273
317655006607	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
317655006608	Walker A/P-loop; other site
317655006609	ATP binding site [chemical binding]; other site
317655006610	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
317655006611	ABC transporter signature motif; other site
317655006612	Walker B; other site
317655006613	D-loop; other site
317655006614	H-loop/switch region; other site
317655006615	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
317655006616	UbiA prenyltransferase family; Region: UbiA; pfam01040
317655006617	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
317655006618	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
317655006619	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
317655006620	TadE-like protein; Region: TadE; pfam07811
317655006621	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
317655006622	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
317655006623	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
317655006624	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
317655006625	metal ion-dependent adhesion site (MIDAS); other site
317655006626	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
317655006627	RNA methyltransferase, RsmE family; Region: TIGR00046
317655006628	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
317655006629	Domain of unknown function DUF11; Region: DUF11; cl17728
317655006630	Domain of unknown function DUF11; Region: DUF11; cl17728
317655006631	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
317655006632	primosome assembly protein PriA; Validated; Region: PRK05580
317655006633	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655006634	ATP binding site [chemical binding]; other site
317655006635	putative Mg++ binding site [ion binding]; other site
317655006636	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
317655006637	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
317655006638	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
317655006639	tetramer interface [polypeptide binding]; other site
317655006640	active site
317655006641	Mg2+/Mn2+ binding site [ion binding]; other site
317655006642	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
317655006643	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
317655006644	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
317655006645	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
317655006646	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
317655006647	DNA binding site [nucleotide binding]
317655006648	active site
317655006649	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
317655006650	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
317655006651	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
317655006652	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
317655006653	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
317655006654	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
317655006655	beta subunit interaction interface [polypeptide binding]; other site
317655006656	Walker A motif; other site
317655006657	ATP binding site [chemical binding]; other site
317655006658	Walker B motif; other site
317655006659	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
317655006660	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
317655006661	core domain interface [polypeptide binding]; other site
317655006662	delta subunit interface [polypeptide binding]; other site
317655006663	epsilon subunit interface [polypeptide binding]; other site
317655006664	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
317655006665	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
317655006666	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
317655006667	alpha subunit interaction interface [polypeptide binding]; other site
317655006668	Walker A motif; other site
317655006669	ATP binding site [chemical binding]; other site
317655006670	Walker B motif; other site
317655006671	inhibitor binding site; inhibition site
317655006672	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
317655006673	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
317655006674	gamma subunit interface [polypeptide binding]; other site
317655006675	epsilon subunit interface [polypeptide binding]; other site
317655006676	LBP interface [polypeptide binding]; other site
317655006677	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
317655006678	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
317655006679	ATP binding site [chemical binding]; other site
317655006680	Walker A motif; other site
317655006681	hexamer interface [polypeptide binding]; other site
317655006682	Walker B motif; other site
317655006683	Predicted methyltransferase [General function prediction only]; Region: COG4798
317655006684	Methyltransferase domain; Region: Methyltransf_23; pfam13489
317655006685	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
317655006686	NADH dehydrogenase; Validated; Region: PRK08183
317655006687	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
317655006688	acyl-CoA synthetase; Validated; Region: PRK09192
317655006689	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
317655006690	acyl-activating enzyme (AAE) consensus motif; other site
317655006691	active site
317655006692	PAS domain S-box; Region: sensory_box; TIGR00229
317655006693	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655006694	putative active site [active]
317655006695	heme pocket [chemical binding]; other site
317655006696	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655006697	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655006698	metal binding site [ion binding]; metal-binding site
317655006699	active site
317655006700	I-site; other site
317655006701	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655006702	CHAP domain; Region: CHAP; cl17642
317655006703	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
317655006704	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
317655006705	DNA methylase; Region: N6_N4_Mtase; pfam01555
317655006706	Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195
317655006707	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
317655006708	pseudouridine synthase; Region: TIGR00093
317655006709	active site
317655006710	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
317655006711	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
317655006712	G1 box; other site
317655006713	putative GEF interaction site [polypeptide binding]; other site
317655006714	GTP/Mg2+ binding site [chemical binding]; other site
317655006715	Switch I region; other site
317655006716	G2 box; other site
317655006717	G3 box; other site
317655006718	Switch II region; other site
317655006719	G4 box; other site
317655006720	G5 box; other site
317655006721	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
317655006722	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
317655006723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655006724	binding surface
317655006725	TPR motif; other site
317655006726	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655006727	binding surface
317655006728	TPR motif; other site
317655006729	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
317655006730	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
317655006731	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
317655006732	ferredoxin-NADP+ reductase; Region: PLN02852
317655006733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
317655006734	Predicted membrane protein [Function unknown]; Region: COG4270
317655006735	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
317655006736	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
317655006737	active site
317655006738	dimer interface [polypeptide binding]; other site
317655006739	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655006740	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655006741	active site
317655006742	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
317655006743	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
317655006744	metal binding site [ion binding]; metal-binding site
317655006745	dimer interface [polypeptide binding]; other site
317655006746	L-aspartate oxidase; Provisional; Region: PRK09077
317655006747	L-aspartate oxidase; Provisional; Region: PRK06175
317655006748	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
317655006749	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
317655006750	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655006751	Walker A/P-loop; other site
317655006752	ATP binding site [chemical binding]; other site
317655006753	Q-loop/lid; other site
317655006754	ABC transporter signature motif; other site
317655006755	Walker B; other site
317655006756	D-loop; other site
317655006757	H-loop/switch region; other site
317655006758	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
317655006759	Zinc-finger domain; Region: zf-CHCC; pfam10276
317655006760	protease TldD; Provisional; Region: tldD; PRK10735
317655006761	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
317655006762	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
317655006763	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
317655006764	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
317655006765	putative catalytic site [active]
317655006766	putative metal binding site [ion binding]; other site
317655006767	putative phosphate binding site [ion binding]; other site
317655006768	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
317655006769	Nitrogen regulatory protein P-II; Region: P-II; smart00938
317655006770	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
317655006771	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655006772	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655006773	N-terminal plug; other site
317655006774	ligand-binding site [chemical binding]; other site
317655006775	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655006776	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
317655006777	active site
317655006778	MarR family; Region: MarR_2; cl17246
317655006779	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655006780	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
317655006781	choline dehydrogenase; Validated; Region: PRK02106
317655006782	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
317655006783	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
317655006784	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
317655006785	Putative phosphatase (DUF442); Region: DUF442; cl17385
317655006786	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
317655006787	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655006788	ATP binding site [chemical binding]; other site
317655006789	putative Mg++ binding site [ion binding]; other site
317655006790	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655006791	nucleotide binding region [chemical binding]; other site
317655006792	ATP-binding site [chemical binding]; other site
317655006793	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
317655006794	HRDC domain; Region: HRDC; pfam00570
317655006795	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
317655006796	amphipathic channel; other site
317655006797	Asn-Pro-Ala signature motifs; other site
317655006798	Low molecular weight phosphatase family; Region: LMWPc; cl00105
317655006799	active site
317655006800	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
317655006801	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655006802	putative metal binding site [ion binding]; other site
317655006803	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655006804	putative DNA binding site [nucleotide binding]; other site
317655006805	putative Zn2+ binding site [ion binding]; other site
317655006806	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
317655006807	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
317655006808	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655006809	Walker A/P-loop; other site
317655006810	ATP binding site [chemical binding]; other site
317655006811	Q-loop/lid; other site
317655006812	ABC transporter signature motif; other site
317655006813	Walker B; other site
317655006814	D-loop; other site
317655006815	H-loop/switch region; other site
317655006816	OstA-like protein; Region: OstA; cl00844
317655006817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
317655006818	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
317655006819	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
317655006820	catalytic site [active]
317655006821	putative active site [active]
317655006822	putative substrate binding site [chemical binding]; other site
317655006823	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
317655006824	DNA-binding site [nucleotide binding]; DNA binding site
317655006825	RNA-binding motif; other site
317655006826	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
317655006827	DNA-binding site [nucleotide binding]; DNA binding site
317655006828	RNA-binding motif; other site
317655006829	Protein of unknown function, DUF606; Region: DUF606; pfam04657
317655006830	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
317655006831	active site 1 [active]
317655006832	dimer interface [polypeptide binding]; other site
317655006833	hexamer interface [polypeptide binding]; other site
317655006834	active site 2 [active]
317655006835	SnoaL-like domain; Region: SnoaL_2; pfam12680
317655006836	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
317655006837	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655006838	active site
317655006839	metal binding site [ion binding]; metal-binding site
317655006840	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
317655006841	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655006842	putative C-terminal domain interface [polypeptide binding]; other site
317655006843	putative GSH binding site (G-site) [chemical binding]; other site
317655006844	putative dimer interface [polypeptide binding]; other site
317655006845	C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206
317655006846	putative N-terminal domain interface [polypeptide binding]; other site
317655006847	putative dimer interface [polypeptide binding]; other site
317655006848	putative substrate binding pocket (H-site) [chemical binding]; other site
317655006849	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
317655006850	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655006851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655006852	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
317655006853	putative effector binding pocket; other site
317655006854	putative dimerization interface [polypeptide binding]; other site
317655006855	MltA-interacting protein MipA; Region: MipA; cl01504
317655006856	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
317655006857	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
317655006858	TPP-binding site; other site
317655006859	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
317655006860	PYR/PP interface [polypeptide binding]; other site
317655006861	dimer interface [polypeptide binding]; other site
317655006862	TPP binding site [chemical binding]; other site
317655006863	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
317655006864	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
317655006865	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
317655006866	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
317655006867	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655006868	active site
317655006869	HIGH motif; other site
317655006870	nucleotide binding site [chemical binding]; other site
317655006871	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
317655006872	active site
317655006873	KMSKS motif; other site
317655006874	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
317655006875	tRNA binding surface [nucleotide binding]; other site
317655006876	anticodon binding site; other site
317655006877	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
317655006878	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
317655006879	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
317655006880	active site
317655006881	Riboflavin kinase; Region: Flavokinase; smart00904
317655006882	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
317655006883	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
317655006884	active site
317655006885	dimer interface [polypeptide binding]; other site
317655006886	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
317655006887	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
317655006888	folate binding site [chemical binding]; other site
317655006889	NADP+ binding site [chemical binding]; other site
317655006890	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
317655006891	ATP-grasp domain; Region: ATP-grasp; pfam02222
317655006892	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
317655006893	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655006894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655006895	metal binding site [ion binding]; metal-binding site
317655006896	active site
317655006897	I-site; other site
317655006898	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
317655006899	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
317655006900	dimerization interface [polypeptide binding]; other site
317655006901	DPS ferroxidase diiron center [ion binding]; other site
317655006902	ion pore; other site
317655006903	Uncharacterized conserved protein [Function unknown]; Region: COG3791
317655006904	Predicted transcriptional regulator [Transcription]; Region: COG2378
317655006905	HTH domain; Region: HTH_11; pfam08279
317655006906	WYL domain; Region: WYL; pfam13280
317655006907	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
317655006908	ThiC-associated domain; Region: ThiC-associated; pfam13667
317655006909	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
317655006910	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
317655006911	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
317655006912	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
317655006913	Protein of unknown function (DUF962); Region: DUF962; pfam06127
317655006914	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
317655006915	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
317655006916	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
317655006917	ligand binding site [chemical binding]; other site
317655006918	active site
317655006919	UGI interface [polypeptide binding]; other site
317655006920	catalytic site [active]
317655006921	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655006922	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655006923	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
317655006924	metal binding site [ion binding]; metal-binding site
317655006925	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
317655006926	nucleotide binding site/active site [active]
317655006927	HIT family signature motif; other site
317655006928	catalytic residue [active]
317655006929	MG2 domain; Region: A2M_N; pfam01835
317655006930	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
317655006931	Alpha-2-macroglobulin family; Region: A2M; pfam00207
317655006932	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
317655006933	Transglycosylase; Region: Transgly; pfam00912
317655006934	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
317655006935	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
317655006936	amino acid transporter; Region: 2A0306; TIGR00909
317655006937	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
317655006938	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
317655006939	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655006940	putative substrate translocation pore; other site
317655006941	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655006942	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
317655006943	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655006944	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
317655006945	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
317655006946	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
317655006947	Penicillin amidase; Region: Penicil_amidase; pfam01804
317655006948	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
317655006949	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
317655006950	active site
317655006951	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
317655006952	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
317655006953	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
317655006954	interface (dimer of trimers) [polypeptide binding]; other site
317655006955	Substrate-binding/catalytic site; other site
317655006956	Zn-binding sites [ion binding]; other site
317655006957	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
317655006958	Clp amino terminal domain; Region: Clp_N; pfam02861
317655006959	Clp amino terminal domain; Region: Clp_N; pfam02861
317655006960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655006961	Walker A motif; other site
317655006962	ATP binding site [chemical binding]; other site
317655006963	Walker B motif; other site
317655006964	arginine finger; other site
317655006965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655006966	Walker A motif; other site
317655006967	ATP binding site [chemical binding]; other site
317655006968	Walker B motif; other site
317655006969	arginine finger; other site
317655006970	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
317655006971	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
317655006972	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
317655006973	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655006974	Outer membrane efflux protein; Region: OEP; pfam02321
317655006975	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
317655006976	Domain of unknown function (DUF4102); Region: DUF4102; pfam13356
317655006977	Winged helix-turn helix; Region: HTH_29; pfam13551
317655006978	Integrase core domain; Region: rve; pfam00665
317655006979	Integrase core domain; Region: rve_3; pfam13683
317655006980	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
317655006981	active site
317655006982	catalytic residues [active]
317655006983	DNA binding site [nucleotide binding]
317655006984	Int/Topo IB signature motif; other site
317655006985	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655006986	dimerization interface [polypeptide binding]; other site
317655006987	putative DNA binding site [nucleotide binding]; other site
317655006988	putative Zn2+ binding site [ion binding]; other site
317655006989	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
317655006990	ArsC family; Region: ArsC; pfam03960
317655006991	catalytic residues [active]
317655006992	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
317655006993	arsenical-resistance protein; Region: acr3; TIGR00832
317655006994	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655006995	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655006996	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
317655006997	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
317655006998	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655006999	DNA-binding site [nucleotide binding]; DNA binding site
317655007000	UTRA domain; Region: UTRA; pfam07702
317655007001	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
317655007002	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
317655007003	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007004	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655007005	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655007006	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
317655007007	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
317655007008	Walker A/P-loop; other site
317655007009	ATP binding site [chemical binding]; other site
317655007010	Q-loop/lid; other site
317655007011	ABC transporter signature motif; other site
317655007012	Walker B; other site
317655007013	D-loop; other site
317655007014	H-loop/switch region; other site
317655007015	cystathionine beta-lyase, bacterial; Region: cysta_beta_ly_B; TIGR01324
317655007016	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
317655007017	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655007018	catalytic residue [active]
317655007019	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
317655007020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655007021	conserved gate region; other site
317655007022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655007023	conserved gate region; other site
317655007024	ABC-ATPase subunit interface; other site
317655007025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
317655007026	dimer interface [polypeptide binding]; other site
317655007027	conserved gate region; other site
317655007028	putative PBP binding loops; other site
317655007029	ABC-ATPase subunit interface; other site
317655007030	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
317655007031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
317655007032	substrate binding pocket [chemical binding]; other site
317655007033	membrane-bound complex binding site; other site
317655007034	hinge residues; other site
317655007035	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
317655007036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655007037	The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456
317655007038	putative dimerization interface [polypeptide binding]; other site
317655007039	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007040	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655007041	N-terminal plug; other site
317655007042	ligand-binding site [chemical binding]; other site
317655007043	Protein of unknown function, DUF; Region: DUF411; cl01142
317655007044	Domain of unknown function (DUF305); Region: DUF305; cl17794
317655007045	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
317655007046	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
317655007047	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
317655007048	Multicopper oxidase; Region: Cu-oxidase; pfam00394
317655007049	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
317655007050	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
317655007051	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655007052	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655007053	DNA binding residues [nucleotide binding]
317655007054	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
317655007055	dimer interface [polypeptide binding]; other site
317655007056	CopC domain; Region: CopC; pfam04234
317655007057	Copper resistance protein D; Region: CopD; cl00563
317655007058	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
317655007059	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
317655007060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655007061	S-adenosylmethionine binding site [chemical binding]; other site
317655007062	YHS domain; Region: YHS; pfam04945
317655007063	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
317655007064	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
317655007065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655007066	motif II; other site
317655007067	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
317655007068	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
317655007069	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
317655007070	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655007071	N-terminal plug; other site
317655007072	ligand-binding site [chemical binding]; other site
317655007073	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
317655007074	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
317655007075	DNA binding residues [nucleotide binding]
317655007076	dimer interface [polypeptide binding]; other site
317655007077	mercury binding site [ion binding]; other site
317655007078	Glutaredoxin; Region: Glutaredoxin; pfam00462
317655007079	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
317655007080	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007081	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
317655007082	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
317655007083	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007084	DNA binding residues [nucleotide binding]
317655007085	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
317655007086	dimer interface [polypeptide binding]; other site
317655007087	putative metal binding site [ion binding]; other site
317655007088	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655007089	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
317655007090	Outer membrane efflux protein; Region: OEP; pfam02321
317655007091	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
317655007092	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
317655007093	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007094	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
317655007095	Helix-turn-helix domain; Region: HTH_28; pfam13518
317655007096	Winged helix-turn helix; Region: HTH_29; pfam13551
317655007097	Homeodomain-like domain; Region: HTH_32; pfam13565
317655007098	Integrase core domain; Region: rve; pfam00665
317655007099	DDE domain; Region: DDE_Tnp_IS240; pfam13610
317655007100	Integrase core domain; Region: rve_3; pfam13683
317655007101	YHS domain; Region: YHS; pfam04945
317655007102	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
317655007103	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
317655007104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655007105	motif II; other site
317655007106	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II and Staphylococcus aureus AldA1 (SACOL0154)-like; Region: ALDH_ACDHII_AcoD-like; cd07559
317655007107	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
317655007108	NAD(P) binding site [chemical binding]; other site
317655007109	catalytic residues [active]
317655007110	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
317655007111	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
317655007112	NAD binding site [chemical binding]; other site
317655007113	substrate binding site [chemical binding]; other site
317655007114	catalytic Zn binding site [ion binding]; other site
317655007115	tetramer interface [polypeptide binding]; other site
317655007116	structural Zn binding site [ion binding]; other site
317655007117	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
317655007118	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
317655007119	Multicopper oxidase; Region: Cu-oxidase; pfam00394
317655007120	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
317655007121	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
317655007122	PAS domain; Region: PAS_9; pfam13426
317655007123	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655007124	putative active site [active]
317655007125	heme pocket [chemical binding]; other site
317655007126	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
317655007127	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
317655007128	putative active site [active]
317655007129	heme pocket [chemical binding]; other site
317655007130	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
317655007131	dimer interface [polypeptide binding]; other site
317655007132	phosphorylation site [posttranslational modification]
317655007133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655007134	ATP binding site [chemical binding]; other site
317655007135	Mg2+ binding site [ion binding]; other site
317655007136	G-X-G motif; other site
317655007137	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
317655007138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655007139	active site
317655007140	phosphorylation site [posttranslational modification]
317655007141	intermolecular recognition site; other site
317655007142	dimerization interface [polypeptide binding]; other site
317655007143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655007144	DNA binding residues [nucleotide binding]
317655007145	dimerization interface [polypeptide binding]; other site
317655007146	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
317655007147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655007148	active site
317655007149	phosphorylation site [posttranslational modification]
317655007150	intermolecular recognition site; other site
317655007151	dimerization interface [polypeptide binding]; other site
317655007152	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655007153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655007154	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
317655007155	dimerization interface [polypeptide binding]; other site
317655007156	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
317655007157	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217
317655007158	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
317655007159	FAD binding pocket [chemical binding]; other site
317655007160	FAD binding motif [chemical binding]; other site
317655007161	phosphate binding motif [ion binding]; other site
317655007162	beta-alpha-beta structure motif; other site
317655007163	NAD binding pocket [chemical binding]; other site
317655007164	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
317655007165	catalytic loop [active]
317655007166	iron binding site [ion binding]; other site
317655007167	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
317655007168	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
317655007169	DNA binding residues [nucleotide binding]
317655007170	dimer interface [polypeptide binding]; other site
317655007171	metal binding site [ion binding]; metal-binding site
317655007172	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
317655007173	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
317655007174	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655007175	active site
317655007176	thymidine phosphorylase; Provisional; Region: PRK04350
317655007177	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
317655007178	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
317655007179	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
317655007180	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
317655007181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655007182	Beta-Casp domain; Region: Beta-Casp; smart01027
317655007183	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
317655007184	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
317655007185	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
317655007186	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
317655007187	VirB7 interaction site; other site
317655007188	conjugal transfer protein TrbF; Provisional; Region: PRK13872
317655007189	conjugal transfer protein TrbL; Provisional; Region: PRK13875
317655007190	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
317655007191	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
317655007192	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
317655007193	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
317655007194	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
317655007195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655007196	Walker A/P-loop; other site
317655007197	ATP binding site [chemical binding]; other site
317655007198	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
317655007199	TrbC/VIRB2 family; Region: TrbC; pfam04956
317655007200	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
317655007201	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655007202	Walker A motif; other site
317655007203	ATP binding site [chemical binding]; other site
317655007204	Walker B motif; other site
317655007205	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
317655007206	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655007207	DNA binding residues [nucleotide binding]
317655007208	dimerization interface [polypeptide binding]; other site
317655007209	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
317655007210	MPN+ (JAMM) motif; other site
317655007211	Zinc-binding site [ion binding]; other site
317655007212	MarR family; Region: MarR_2; pfam12802
317655007213	Transcriptional regulators [Transcription]; Region: MarR; COG1846
317655007214	TrwC relaxase; Region: TrwC; pfam08751
317655007215	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
317655007216	AAA domain; Region: AAA_30; pfam13604
317655007217	Family description; Region: UvrD_C_2; pfam13538
317655007218	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655007219	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
317655007220	Walker A motif; other site
317655007221	ATP binding site [chemical binding]; other site
317655007222	Walker B motif; other site
317655007223	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
317655007224	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655007225	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655007226	catalytic residue [active]
317655007227	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
317655007228	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
317655007229	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
317655007230	Helix-turn-helix domain; Region: HTH_17; pfam12728
317655007231	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
317655007232	Uncharacterized conserved protein [Function unknown]; Region: COG5489
317655007233	Protein of unknown function (DUF736); Region: DUF736; pfam05284
317655007234	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655007235	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655007236	Beta-lactamase; Region: Beta-lactamase; cl17358
317655007237	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007238	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655007239	N-terminal plug; other site
317655007240	ligand-binding site [chemical binding]; other site
317655007241	Transcriptional regulators [Transcription]; Region: FadR; COG2186
317655007242	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655007243	DNA-binding site [nucleotide binding]; DNA binding site
317655007244	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655007245	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655007246	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007247	DNA binding residues [nucleotide binding]
317655007248	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
317655007249	dimer interface [polypeptide binding]; other site
317655007250	putative metal binding site [ion binding]; other site
317655007251	MerT mercuric transport protein; Region: MerT; cl03578
317655007252	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
317655007253	metal-binding site [ion binding]
317655007254	mercuric reductase; Region: MerA; TIGR02053
317655007255	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655007256	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655007257	Abi-like protein; Region: Abi_2; pfam07751
317655007258	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
317655007259	active site
317655007260	NTP binding site [chemical binding]; other site
317655007261	metal binding triad [ion binding]; metal-binding site
317655007262	antibiotic binding site [chemical binding]; other site
317655007263	HEPN domain; Region: HEPN; cl00824
317655007264	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
317655007265	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
317655007266	active site
317655007267	metal binding site [ion binding]; metal-binding site
317655007268	interdomain interaction site; other site
317655007269	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
317655007270	ParB-like nuclease domain; Region: ParBc; pfam02195
317655007271	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
317655007272	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
317655007273	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
317655007274	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
317655007275	Autoinducer binding domain; Region: Autoind_bind; pfam03472
317655007276	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655007277	DNA binding residues [nucleotide binding]
317655007278	dimerization interface [polypeptide binding]; other site
317655007279	Autoinducer synthetase; Region: Autoind_synth; cl17404
317655007280	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
317655007281	Transcriptional regulators [Transcription]; Region: GntR; COG1802
317655007282	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655007283	DNA-binding site [nucleotide binding]; DNA binding site
317655007284	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
317655007285	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655007286	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655007287	DNA binding residues [nucleotide binding]
317655007288	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
317655007289	FecR protein; Region: FecR; pfam04773
317655007290	Secretin and TonB N terminus short domain; Region: STN; smart00965
317655007291	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007292	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655007293	N-terminal plug; other site
317655007294	ligand-binding site [chemical binding]; other site
317655007295	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
317655007296	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655007297	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
317655007298	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
317655007299	Ligand Binding Site [chemical binding]; other site
317655007300	Molecular Tunnel; other site
317655007301	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
317655007302	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
317655007303	active site
317655007304	DNA binding site [nucleotide binding]
317655007305	Int/Topo IB signature motif; other site
317655007306	arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690
317655007307	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655007308	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
317655007309	Sodium Bile acid symporter family; Region: SBF; cl17470
317655007310	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
317655007311	ArsC family; Region: ArsC; pfam03960
317655007312	catalytic residues [active]
317655007313	Low molecular weight phosphatase family; Region: LMWPc; cd00115
317655007314	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
317655007315	active site
317655007316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655007317	dimerization interface [polypeptide binding]; other site
317655007318	putative DNA binding site [nucleotide binding]; other site
317655007319	putative Zn2+ binding site [ion binding]; other site
317655007320	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
317655007321	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
317655007322	DNA binding residues [nucleotide binding]
317655007323	dimer interface [polypeptide binding]; other site
317655007324	copper binding site [ion binding]; other site
317655007325	YHS domain; Region: YHS; pfam04945
317655007326	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
317655007327	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
317655007328	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655007329	motif II; other site
317655007330	Protein of unknown function, DUF; Region: DUF411; cl01142
317655007331	Outer membrane efflux protein; Region: OEP; pfam02321
317655007332	Outer membrane efflux protein; Region: OEP; pfam02321
317655007333	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
317655007334	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007335	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
317655007336	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
317655007337	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
317655007338	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
317655007339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655007340	NAD(P) binding site [chemical binding]; other site
317655007341	active site
317655007342	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
317655007343	putative active site [active]
317655007344	redox center [active]
317655007345	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655007346	Cytochrome P450; Region: p450; cl12078
317655007347	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007348	DNA binding residues [nucleotide binding]
317655007349	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
317655007350	dimer interface [polypeptide binding]; other site
317655007351	putative metal binding site [ion binding]; other site
317655007352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655007353	S-adenosylmethionine binding site [chemical binding]; other site
317655007354	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655007355	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
317655007356	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
317655007357	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007358	DNA binding residues [nucleotide binding]
317655007359	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
317655007360	dimer interface [polypeptide binding]; other site
317655007361	putative metal binding site [ion binding]; other site
317655007362	MerT mercuric transport protein; Region: MerT; cl03578
317655007363	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
317655007364	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
317655007365	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
317655007366	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007367	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
317655007368	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
317655007369	Eukaryotic phosphomannomutase; Region: PMM; cl17107
317655007370	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
317655007371	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007372	DNA binding residues [nucleotide binding]
317655007373	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
317655007374	dimer interface [polypeptide binding]; other site
317655007375	putative metal binding site [ion binding]; other site
317655007376	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655007377	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
317655007378	Ligand Binding Site [chemical binding]; other site
317655007379	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655007380	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
317655007381	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
317655007382	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007383	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
317655007384	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
317655007385	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
317655007386	putative hydrophobic ligand binding site [chemical binding]; other site
317655007387	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
317655007388	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
317655007389	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
317655007390	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
317655007391	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
317655007392	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
317655007393	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
317655007394	putative hydrophobic ligand binding site [chemical binding]; other site
317655007395	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
317655007396	Autoinducer binding domain; Region: Autoind_bind; pfam03472
317655007397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655007398	DNA binding residues [nucleotide binding]
317655007399	dimerization interface [polypeptide binding]; other site
317655007400	Autoinducer synthetase; Region: Autoind_synth; cl17404
317655007401	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
317655007402	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
317655007403	DNA-binding site [nucleotide binding]; DNA binding site
317655007404	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
317655007405	putative active site [active]
317655007406	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
317655007407	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
317655007408	active site
317655007409	NTP binding site [chemical binding]; other site
317655007410	metal binding triad [ion binding]; metal-binding site
317655007411	antibiotic binding site [chemical binding]; other site
317655007412	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
317655007413	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
317655007414	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
317655007415	oligomeric interface; other site
317655007416	putative active site [active]
317655007417	homodimer interface [polypeptide binding]; other site
317655007418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655007419	RNA polymerase factor sigma-70; Validated; Region: PRK09047
317655007420	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655007421	DNA binding residues [nucleotide binding]
317655007422	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
317655007423	FecR protein; Region: FecR; pfam04773
317655007424	Secretin and TonB N terminus short domain; Region: STN; smart00965
317655007425	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655007426	N-terminal plug; other site
317655007427	ligand-binding site [chemical binding]; other site
317655007428	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007429	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
317655007430	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655007431	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
317655007432	Ligand Binding Site [chemical binding]; other site
317655007433	Molecular Tunnel; other site
317655007434	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
317655007435	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
317655007436	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
317655007437	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
317655007438	VirB7 interaction site; other site
317655007439	conjugal transfer protein TrbF; Provisional; Region: PRK13872
317655007440	conjugal transfer protein TrbL; Provisional; Region: PRK13875
317655007441	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
317655007442	conjugative transfer region protein TrbK; Region: other_trbK; TIGR04360
317655007443	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
317655007444	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
317655007445	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
317655007446	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655007447	Walker A/P-loop; other site
317655007448	ATP binding site [chemical binding]; other site
317655007449	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
317655007450	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
317655007451	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
317655007452	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
317655007453	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655007454	Walker A motif; other site
317655007455	ATP binding site [chemical binding]; other site
317655007456	Walker B motif; other site
317655007457	Fic family protein [Function unknown]; Region: COG3177
317655007458	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
317655007459	Fic/DOC family; Region: Fic; pfam02661
317655007460	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
317655007461	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
317655007462	Walker A motif; other site
317655007463	ATP binding site [chemical binding]; other site
317655007464	Walker B motif; other site
317655007465	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
317655007466	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
317655007467	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
317655007468	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655007469	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655007470	catalytic residue [active]
317655007471	Protein of unknown function (DUF736); Region: DUF736; pfam05284
317655007472	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
317655007473	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
317655007474	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
317655007475	Replication initiator protein A; Region: RPA; pfam10134
317655007476	Helix-turn-helix domain; Region: HTH_17; pfam12728
317655007477	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
317655007478	Uncharacterized conserved protein [Function unknown]; Region: COG5489
317655007479	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
317655007480	IHF dimer interface [polypeptide binding]; other site
317655007481	IHF - DNA interface [nucleotide binding]; other site
317655007482	Protein of unknown function (DUF736); Region: DUF736; pfam05284
317655007483	PLD-like domain; Region: PLDc_2; pfam13091
317655007484	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
317655007485	putative active site [active]
317655007486	catalytic site [active]
317655007487	DEAD/DEAH box helicase; Region: DEAD; pfam00270
317655007488	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655007489	ATP-binding site [chemical binding]; other site
317655007490	AAA ATPase domain; Region: AAA_16; pfam13191
317655007491	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655007492	ATP binding site [chemical binding]; other site
317655007493	putative Mg++ binding site [ion binding]; other site
317655007494	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655007495	nucleotide binding region [chemical binding]; other site
317655007496	ATP-binding site [chemical binding]; other site
317655007497	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655007498	ATP binding site [chemical binding]; other site
317655007499	putative Mg++ binding site [ion binding]; other site
317655007500	nucleotide binding region [chemical binding]; other site
317655007501	helicase superfamily c-terminal domain; Region: HELICc; smart00490
317655007502	ATP-binding site [chemical binding]; other site
317655007503	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
317655007504	Ligand Binding Site [chemical binding]; other site
317655007505	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
317655007506	active site
317655007507	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
317655007508	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
317655007509	DGQHR domain; Region: DGQHR; TIGR03187
317655007510	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
317655007511	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
317655007512	DGQHR domain; Region: DGQHR; TIGR03187
317655007513	DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172
317655007514	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
317655007515	Toprim domain; Region: Toprim_3; pfam13362
317655007516	Methyltransferase domain; Region: Methyltransf_26; pfam13659
317655007517	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
317655007518	Helicase_C-like; Region: Helicase_C_4; pfam13871
317655007519	Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502
317655007520	ParB-like nuclease domain; Region: ParBc; cl02129
317655007521	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
317655007522	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
317655007523	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
317655007524	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
317655007525	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
317655007526	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
317655007527	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
317655007528	catalytic residues [active]
317655007529	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
317655007530	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
317655007531	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
317655007532	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
317655007533	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
317655007534	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
317655007535	Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548
317655007536	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
317655007537	putative catalytic site [active]
317655007538	putative phosphate binding site [ion binding]; other site
317655007539	active site
317655007540	metal binding site A [ion binding]; metal-binding site
317655007541	DNA binding site [nucleotide binding]
317655007542	putative AP binding site [nucleotide binding]; other site
317655007543	putative metal binding site B [ion binding]; other site
317655007544	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
317655007545	dimerization interface [polypeptide binding]; other site
317655007546	active site
317655007547	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
317655007548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655007549	active site
317655007550	phosphorylation site [posttranslational modification]
317655007551	intermolecular recognition site; other site
317655007552	dimerization interface [polypeptide binding]; other site
317655007553	LytTr DNA-binding domain; Region: LytTR; smart00850
317655007554	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
317655007555	Histidine kinase; Region: His_kinase; pfam06580
317655007556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655007557	ATP binding site [chemical binding]; other site
317655007558	Mg2+ binding site [ion binding]; other site
317655007559	G-X-G motif; other site
317655007560	Predicted transcriptional regulators [Transcription]; Region: COG1733
317655007561	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655007562	dimerization interface [polypeptide binding]; other site
317655007563	putative DNA binding site [nucleotide binding]; other site
317655007564	putative Zn2+ binding site [ion binding]; other site
317655007565	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
317655007566	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
317655007567	active site
317655007568	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
317655007569	HD domain; Region: HD_4; pfam13328
317655007570	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
317655007571	synthetase active site [active]
317655007572	NTP binding site [chemical binding]; other site
317655007573	metal binding site [ion binding]; metal-binding site
317655007574	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
317655007575	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
317655007576	DoxX; Region: DoxX; pfam07681
317655007577	RNA polymerase sigma factor; Provisional; Region: PRK12539
317655007578	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655007579	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655007580	DNA binding residues [nucleotide binding]
317655007581	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
317655007582	mercuric reductase; Region: MerA; TIGR02053
317655007583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655007584	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655007585	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
317655007586	metal-binding site [ion binding]
317655007587	MerT mercuric transport protein; Region: MerT; cl03578
317655007588	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
317655007589	DNA binding residues [nucleotide binding]
317655007590	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
317655007591	dimer interface [polypeptide binding]; other site
317655007592	putative metal binding site [ion binding]; other site
317655007593	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
317655007594	FOG: CBS domain [General function prediction only]; Region: COG0517
317655007595	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
317655007596	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
317655007597	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
317655007598	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655007599	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655007600	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
317655007601	active site 1 [active]
317655007602	dimer interface [polypeptide binding]; other site
317655007603	hexamer interface [polypeptide binding]; other site
317655007604	active site 2 [active]
317655007605	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
317655007606	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
317655007607	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
317655007608	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
317655007609	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
317655007610	Nucleoside recognition; Region: Gate; pfam07670
317655007611	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
317655007612	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
317655007613	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655007614	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655007615	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
317655007616	catalytic residues [active]
317655007617	Uncharacterized conserved protein [Function unknown]; Region: COG0398
317655007618	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
317655007619	mercuric reductase; Validated; Region: PRK06370
317655007620	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
317655007621	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
317655007622	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
317655007623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655007624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655007625	DNA binding residues [nucleotide binding]
317655007626	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
317655007627	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
317655007628	FOG: CBS domain [General function prediction only]; Region: COG0517
317655007629	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
317655007630	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
317655007631	Uncharacterized conserved protein [Function unknown]; Region: COG5316
317655007632	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
317655007633	Uncharacterized conserved protein [Function unknown]; Region: COG5316
317655007634	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
317655007635	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
317655007636	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
317655007637	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655007638	S-adenosylmethionine binding site [chemical binding]; other site
317655007639	peptide chain release factor 1; Validated; Region: prfA; PRK00591
317655007640	This domain is found in peptide chain release factors; Region: PCRF; smart00937
317655007641	RF-1 domain; Region: RF-1; pfam00472
317655007642	histidyl-tRNA synthetase; Region: hisS; TIGR00442
317655007643	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
317655007644	dimer interface [polypeptide binding]; other site
317655007645	motif 1; other site
317655007646	active site
317655007647	motif 2; other site
317655007648	motif 3; other site
317655007649	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
317655007650	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
317655007651	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
317655007652	protein binding site [polypeptide binding]; other site
317655007653	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
317655007654	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
317655007655	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
317655007656	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
317655007657	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
317655007658	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
317655007659	oligomeric interface; other site
317655007660	putative active site [active]
317655007661	homodimer interface [polypeptide binding]; other site
317655007662	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
317655007663	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
317655007664	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655007665	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
317655007666	dimerization interface [polypeptide binding]; other site
317655007667	substrate binding pocket [chemical binding]; other site
317655007668	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
317655007669	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655007670	ligand binding site [chemical binding]; other site
317655007671	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
317655007672	RimM N-terminal domain; Region: RimM; pfam01782
317655007673	PRC-barrel domain; Region: PRC; pfam05239
317655007674	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
317655007675	signal recognition particle protein; Provisional; Region: PRK10867
317655007676	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
317655007677	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
317655007678	P loop; other site
317655007679	GTP binding site [chemical binding]; other site
317655007680	Signal peptide binding domain; Region: SRP_SPB; pfam02978
317655007681	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
317655007682	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
317655007683	metal binding site [ion binding]; metal-binding site
317655007684	active site
317655007685	I-site; other site
317655007686	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
317655007687	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
317655007688	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
317655007689	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
317655007690	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
317655007691	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
317655007692	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
317655007693	FeS/SAM binding site; other site
317655007694	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
317655007695	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
317655007696	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
317655007697	P loop; other site
317655007698	GTP binding site [chemical binding]; other site
317655007699	Intracellular septation protein A; Region: IspA; pfam04279
317655007700	Predicted membrane protein [Function unknown]; Region: COG3748
317655007701	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
317655007702	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
317655007703	trimer interface [polypeptide binding]; other site
317655007704	putative metal binding site [ion binding]; other site
317655007705	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655007706	S-adenosylmethionine binding site [chemical binding]; other site
317655007707	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
317655007708	dimer interface [polypeptide binding]; other site
317655007709	active site
317655007710	aspartate-rich active site metal binding site; other site
317655007711	allosteric magnesium binding site [ion binding]; other site
317655007712	Schiff base residues; other site
317655007713	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
317655007714	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655007715	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
317655007716	ATP binding site [chemical binding]; other site
317655007717	putative Mg++ binding site [ion binding]; other site
317655007718	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655007719	nucleotide binding region [chemical binding]; other site
317655007720	ATP-binding site [chemical binding]; other site
317655007721	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
317655007722	RNA binding surface [nucleotide binding]; other site
317655007723	Ferredoxin [Energy production and conversion]; Region: COG1146
317655007724	4Fe-4S binding domain; Region: Fer4; cl02805
317655007725	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
317655007726	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
317655007727	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
317655007728	oligomer interface [polypeptide binding]; other site
317655007729	active site residues [active]
317655007730	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
317655007731	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
317655007732	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655007733	Walker A motif; other site
317655007734	ATP binding site [chemical binding]; other site
317655007735	Walker B motif; other site
317655007736	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
317655007737	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
317655007738	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655007739	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
317655007740	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
317655007741	minor groove reading motif; other site
317655007742	helix-hairpin-helix signature motif; other site
317655007743	substrate binding pocket [chemical binding]; other site
317655007744	active site
317655007745	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
317655007746	dihydrodipicolinate reductase; Provisional; Region: PRK00048
317655007747	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
317655007748	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
317655007749	NAD-dependent deacetylase; Provisional; Region: PRK00481
317655007750	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
317655007751	NAD+ binding site [chemical binding]; other site
317655007752	substrate binding site [chemical binding]; other site
317655007753	Zn binding site [ion binding]; other site
317655007754	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
317655007755	nucleoside/Zn binding site; other site
317655007756	dimer interface [polypeptide binding]; other site
317655007757	catalytic motif [active]
317655007758	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
317655007759	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
317655007760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
317655007761	exopolyphosphatase; Region: exo_poly_only; TIGR03706
317655007762	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
317655007763	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
317655007764	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
317655007765	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
317655007766	Catalytic dyad [active]
317655007767	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
317655007768	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
317655007769	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
317655007770	catalytic triad [active]
317655007771	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
317655007772	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
317655007773	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
317655007774	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
317655007775	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655007776	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
317655007777	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
317655007778	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
317655007779	ATP binding site [chemical binding]; other site
317655007780	Walker A motif; other site
317655007781	hexamer interface [polypeptide binding]; other site
317655007782	Walker B motif; other site
317655007783	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
317655007784	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655007785	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
317655007786	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
317655007787	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655007788	binding surface
317655007789	Tetratricopeptide repeat; Region: TPR_16; pfam13432
317655007790	TPR motif; other site
317655007791	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
317655007792	Uncharacterized conserved protein [Function unknown]; Region: COG5276
317655007793	LVIVD repeat; Region: LVIVD; pfam08309
317655007794	Domain of unknown function (DUF336); Region: DUF336; cl01249
317655007795	Domain of unknown function (DUF336); Region: DUF336; cl01249
317655007796	Domain of unknown function (DUF336); Region: DUF336; cl01249
317655007797	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
317655007798	glutamate dehydrogenase; Provisional; Region: PRK09414
317655007799	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
317655007800	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
317655007801	NAD(P) binding site [chemical binding]; other site
317655007802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655007803	TPR motif; other site
317655007804	TPR repeat; Region: TPR_11; pfam13414
317655007805	binding surface
317655007806	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
317655007807	Proline dehydrogenase; Region: Pro_dh; pfam01619
317655007808	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
317655007809	Glutamate binding site [chemical binding]; other site
317655007810	NAD binding site [chemical binding]; other site
317655007811	catalytic residues [active]
317655007812	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
317655007813	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
317655007814	putative DNA binding site [nucleotide binding]; other site
317655007815	putative Zn2+ binding site [ion binding]; other site
317655007816	AsnC family; Region: AsnC_trans_reg; pfam01037
317655007817	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
317655007818	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
317655007819	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655007820	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655007821	putative substrate translocation pore; other site
317655007822	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
317655007823	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
317655007824	putative MPT binding site; other site
317655007825	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
317655007826	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
317655007827	putative C-terminal domain interface [polypeptide binding]; other site
317655007828	putative GSH binding site (G-site) [chemical binding]; other site
317655007829	putative dimer interface [polypeptide binding]; other site
317655007830	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
317655007831	dimer interface [polypeptide binding]; other site
317655007832	N-terminal domain interface [polypeptide binding]; other site
317655007833	putative substrate binding pocket (H-site) [chemical binding]; other site
317655007834	DNA Polymerase Y-family; Region: PolY_like; cd03468
317655007835	active site
317655007836	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
317655007837	DNA binding site [nucleotide binding]
317655007838	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
317655007839	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
317655007840	putative active site [active]
317655007841	putative PHP Thumb interface [polypeptide binding]; other site
317655007842	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
317655007843	generic binding surface II; other site
317655007844	generic binding surface I; other site
317655007845	Helix-turn-helix domain; Region: HTH_18; pfam12833
317655007846	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
317655007847	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
317655007848	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
317655007849	dimer interface [polypeptide binding]; other site
317655007850	motif 1; other site
317655007851	active site
317655007852	motif 2; other site
317655007853	motif 3; other site
317655007854	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
317655007855	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
317655007856	putative tRNA-binding site [nucleotide binding]; other site
317655007857	B3/4 domain; Region: B3_4; pfam03483
317655007858	tRNA synthetase B5 domain; Region: B5; smart00874
317655007859	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
317655007860	dimer interface [polypeptide binding]; other site
317655007861	motif 1; other site
317655007862	motif 3; other site
317655007863	motif 2; other site
317655007864	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
317655007865	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
317655007866	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
317655007867	Sulfate transporter family; Region: Sulfate_transp; pfam00916
317655007868	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
317655007869	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
317655007870	Ligand Binding Site [chemical binding]; other site
317655007871	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
317655007872	Ligand Binding Site [chemical binding]; other site
317655007873	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
317655007874	PII uridylyl-transferase; Provisional; Region: PRK05092
317655007875	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
317655007876	metal binding triad; other site
317655007877	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
317655007878	HD domain; Region: HD; pfam01966
317655007879	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
317655007880	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
317655007881	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
317655007882	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
317655007883	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655007884	Coenzyme A binding pocket [chemical binding]; other site
317655007885	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
317655007886	MutS domain I; Region: MutS_I; pfam01624
317655007887	MutS domain II; Region: MutS_II; pfam05188
317655007888	MutS domain III; Region: MutS_III; pfam05192
317655007889	MutS domain III; Region: MutS_III; pfam05192
317655007890	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
317655007891	Walker A/P-loop; other site
317655007892	ATP binding site [chemical binding]; other site
317655007893	Q-loop/lid; other site
317655007894	ABC transporter signature motif; other site
317655007895	Walker B; other site
317655007896	D-loop; other site
317655007897	H-loop/switch region; other site
317655007898	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
317655007899	Malic enzyme, N-terminal domain; Region: malic; pfam00390
317655007900	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
317655007901	putative NAD(P) binding site [chemical binding]; other site
317655007902	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
317655007903	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
317655007904	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
317655007905	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
317655007906	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
317655007907	adenylate kinase; Reviewed; Region: adk; PRK00279
317655007908	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
317655007909	AMP-binding site [chemical binding]; other site
317655007910	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
317655007911	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
317655007912	SecY translocase; Region: SecY; pfam00344
317655007913	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
317655007914	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
317655007915	23S rRNA binding site [nucleotide binding]; other site
317655007916	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
317655007917	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
317655007918	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
317655007919	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
317655007920	5S rRNA interface [nucleotide binding]; other site
317655007921	23S rRNA interface [nucleotide binding]; other site
317655007922	L5 interface [polypeptide binding]; other site
317655007923	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
317655007924	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
317655007925	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
317655007926	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
317655007927	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
317655007928	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
317655007929	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
317655007930	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
317655007931	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
317655007932	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
317655007933	RNA binding site [nucleotide binding]; other site
317655007934	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
317655007935	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
317655007936	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
317655007937	putative translocon interaction site; other site
317655007938	signal recognition particle (SRP54) interaction site; other site
317655007939	L23 interface [polypeptide binding]; other site
317655007940	trigger factor interaction site; other site
317655007941	23S rRNA interface [nucleotide binding]; other site
317655007942	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
317655007943	23S rRNA interface [nucleotide binding]; other site
317655007944	5S rRNA interface [nucleotide binding]; other site
317655007945	putative antibiotic binding site [chemical binding]; other site
317655007946	L25 interface [polypeptide binding]; other site
317655007947	L27 interface [polypeptide binding]; other site
317655007948	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
317655007949	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
317655007950	G-X-X-G motif; other site
317655007951	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
317655007952	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
317655007953	putative translocon binding site; other site
317655007954	protein-rRNA interface [nucleotide binding]; other site
317655007955	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
317655007956	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
317655007957	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
317655007958	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
317655007959	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
317655007960	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
317655007961	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
317655007962	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
317655007963	elongation factor Tu; Reviewed; Region: PRK00049
317655007964	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
317655007965	G1 box; other site
317655007966	GEF interaction site [polypeptide binding]; other site
317655007967	GTP/Mg2+ binding site [chemical binding]; other site
317655007968	Switch I region; other site
317655007969	G2 box; other site
317655007970	G3 box; other site
317655007971	Switch II region; other site
317655007972	G4 box; other site
317655007973	G5 box; other site
317655007974	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
317655007975	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
317655007976	Antibiotic Binding Site [chemical binding]; other site
317655007977	elongation factor G; Reviewed; Region: PRK00007
317655007978	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
317655007979	G1 box; other site
317655007980	putative GEF interaction site [polypeptide binding]; other site
317655007981	GTP/Mg2+ binding site [chemical binding]; other site
317655007982	Switch I region; other site
317655007983	G2 box; other site
317655007984	G3 box; other site
317655007985	Switch II region; other site
317655007986	G4 box; other site
317655007987	G5 box; other site
317655007988	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
317655007989	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
317655007990	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
317655007991	30S ribosomal protein S7; Validated; Region: PRK05302
317655007992	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
317655007993	S17 interaction site [polypeptide binding]; other site
317655007994	S8 interaction site; other site
317655007995	16S rRNA interaction site [nucleotide binding]; other site
317655007996	streptomycin interaction site [chemical binding]; other site
317655007997	23S rRNA interaction site [nucleotide binding]; other site
317655007998	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
317655007999	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
317655008000	catalytic nucleophile [active]
317655008001	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
317655008002	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
317655008003	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
317655008004	active site
317655008005	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
317655008006	catalytic triad [active]
317655008007	putative active site [active]
317655008008	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
317655008009	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655008010	motif II; other site
317655008011	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
317655008012	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
317655008013	trimer interface [polypeptide binding]; other site
317655008014	active site
317655008015	substrate binding site [chemical binding]; other site
317655008016	CoA binding site [chemical binding]; other site
317655008017	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
317655008018	catalytic core [active]
317655008019	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
317655008020	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
317655008021	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
317655008022	putative dimer interface [polypeptide binding]; other site
317655008023	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655008024	Coenzyme A binding pocket [chemical binding]; other site
317655008025	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
317655008026	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
317655008027	active site
317655008028	Zn binding site [ion binding]; other site
317655008029	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
317655008030	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
317655008031	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
317655008032	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
317655008033	active site
317655008034	phosphorylation site [posttranslational modification]
317655008035	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
317655008036	30S subunit binding site; other site
317655008037	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
317655008038	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
317655008039	active site
317655008040	catalytic site [active]
317655008041	substrate binding site [chemical binding]; other site
317655008042	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
317655008043	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
317655008044	CoA-binding site [chemical binding]; other site
317655008045	ATP-binding [chemical binding]; other site
317655008046	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
317655008047	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
317655008048	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
317655008049	shikimate binding site; other site
317655008050	NAD(P) binding site [chemical binding]; other site
317655008051	Maf-like protein; Region: Maf; pfam02545
317655008052	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
317655008053	active site
317655008054	dimer interface [polypeptide binding]; other site
317655008055	PEP synthetase regulatory protein; Provisional; Region: PRK05339
317655008056	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
317655008057	substrate binding site [chemical binding]; other site
317655008058	active site
317655008059	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
317655008060	transcription termination factor Rho; Provisional; Region: rho; PRK09376
317655008061	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
317655008062	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
317655008063	RNA binding site [nucleotide binding]; other site
317655008064	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
317655008065	multimer interface [polypeptide binding]; other site
317655008066	Walker A motif; other site
317655008067	ATP binding site [chemical binding]; other site
317655008068	Walker B motif; other site
317655008069	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
317655008070	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
317655008071	inhibitor binding site; inhibition site
317655008072	catalytic motif [active]
317655008073	Catalytic residue [active]
317655008074	Active site flap [active]
317655008075	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
317655008076	SnoaL-like domain; Region: SnoaL_2; pfam12680
317655008077	Dienelactone hydrolase family; Region: DLH; pfam01738
317655008078	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
317655008079	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
317655008080	trmE is a tRNA modification GTPase; Region: trmE; cd04164
317655008081	G1 box; other site
317655008082	GTP/Mg2+ binding site [chemical binding]; other site
317655008083	Switch I region; other site
317655008084	G2 box; other site
317655008085	Switch II region; other site
317655008086	G3 box; other site
317655008087	G4 box; other site
317655008088	G5 box; other site
317655008089	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
317655008090	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
317655008091	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
317655008092	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
317655008093	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
317655008094	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
317655008095	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
317655008096	P-loop; other site
317655008097	Magnesium ion binding site [ion binding]; other site
317655008098	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
317655008099	Magnesium ion binding site [ion binding]; other site
317655008100	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
317655008101	ParB-like nuclease domain; Region: ParBc; pfam02195
317655008102	KorB domain; Region: KorB; pfam08535
317655008103	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
317655008104	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
317655008105	hypothetical protein; Provisional; Region: PRK07208
317655008106	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
317655008107	GtrA-like protein; Region: GtrA; pfam04138
317655008108	oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154
317655008109	methionine sulfoxide reductase B; Provisional; Region: PRK00222
317655008110	SelR domain; Region: SelR; pfam01641
317655008111	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
317655008112	Cytochrome P450; Region: p450; cl12078
317655008113	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
317655008114	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
317655008115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
317655008116	Walker A/P-loop; other site
317655008117	ATP binding site [chemical binding]; other site
317655008118	Q-loop/lid; other site
317655008119	ABC transporter signature motif; other site
317655008120	Walker B; other site
317655008121	D-loop; other site
317655008122	H-loop/switch region; other site
317655008123	epoxyqueuosine reductase; Region: TIGR00276
317655008124	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
317655008125	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
317655008126	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
317655008127	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
317655008128	substrate binding site [chemical binding]; other site
317655008129	ATP binding site [chemical binding]; other site
317655008130	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
317655008131	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
317655008132	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
317655008133	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
317655008134	UGMP family protein; Validated; Region: PRK09604
317655008135	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
317655008136	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
317655008137	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
317655008138	domain interfaces; other site
317655008139	active site
317655008140	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
317655008141	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
317655008142	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
317655008143	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008144	FAD binding site [chemical binding]; other site
317655008145	substrate binding pocket [chemical binding]; other site
317655008146	catalytic base [active]
317655008147	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
317655008148	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655008149	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655008150	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655008151	N-terminal plug; other site
317655008152	ligand-binding site [chemical binding]; other site
317655008153	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655008154	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655008155	WHG domain; Region: WHG; pfam13305
317655008156	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
317655008157	Methyltransferase domain; Region: Methyltransf_23; pfam13489
317655008158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655008159	S-adenosylmethionine binding site [chemical binding]; other site
317655008160	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
317655008161	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
317655008162	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
317655008163	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
317655008164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655008165	homodimer interface [polypeptide binding]; other site
317655008166	catalytic residue [active]
317655008167	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
317655008168	prephenate dehydrogenase; Validated; Region: PRK08507
317655008169	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
317655008170	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
317655008171	putative acyl-acceptor binding pocket; other site
317655008172	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
317655008173	putative active site [active]
317655008174	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
317655008175	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
317655008176	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
317655008177	Walker A/P-loop; other site
317655008178	ATP binding site [chemical binding]; other site
317655008179	Q-loop/lid; other site
317655008180	ABC transporter signature motif; other site
317655008181	Walker B; other site
317655008182	D-loop; other site
317655008183	H-loop/switch region; other site
317655008184	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
317655008185	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
317655008186	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
317655008187	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
317655008188	CoA-transferase family III; Region: CoA_transf_3; pfam02515
317655008189	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
317655008190	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655008191	dimer interface [polypeptide binding]; other site
317655008192	active site
317655008193	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008194	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655008195	active site
317655008196	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
317655008197	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655008198	DNA binding residues [nucleotide binding]
317655008199	dimerization interface [polypeptide binding]; other site
317655008200	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
317655008201	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655008202	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655008203	DNA binding residues [nucleotide binding]
317655008204	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
317655008205	FHIPEP family; Region: FHIPEP; pfam00771
317655008206	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
317655008207	N-acetyl-D-glucosamine binding site [chemical binding]; other site
317655008208	catalytic residue [active]
317655008209	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
317655008210	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
317655008211	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
317655008212	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
317655008213	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
317655008214	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
317655008215	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
317655008216	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
317655008217	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
317655008218	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
317655008219	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
317655008220	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
317655008221	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
317655008222	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
317655008223	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
317655008224	Flagellar L-ring protein; Region: FlgH; pfam02107
317655008225	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
317655008226	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
317655008227	Rod binding protein; Region: Rod-binding; pfam10135
317655008228	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
317655008229	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
317655008230	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
317655008231	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
317655008232	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
317655008233	flagellar motor protein MotA; Validated; Region: PRK09110
317655008234	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
317655008235	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
317655008236	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655008237	ligand binding site [chemical binding]; other site
317655008238	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
317655008239	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655008240	Walker A motif; other site
317655008241	ATP binding site [chemical binding]; other site
317655008242	Walker B motif; other site
317655008243	arginine finger; other site
317655008244	Flagellar protein FliS; Region: FliS; cl00654
317655008245	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
317655008246	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
317655008247	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
317655008248	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
317655008249	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
317655008250	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
317655008251	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
317655008252	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
317655008253	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
317655008254	flagellar motor switch protein FliN; Region: fliN; TIGR02480
317655008255	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
317655008256	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
317655008257	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
317655008258	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
317655008259	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
317655008260	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
317655008261	Walker A motif; other site
317655008262	ATP binding site [chemical binding]; other site
317655008263	Walker B motif; other site
317655008264	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
317655008265	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
317655008266	FliG C-terminal domain; Region: FliG_C; pfam01706
317655008267	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
317655008268	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
317655008269	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
317655008270	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
317655008271	flagellin; Provisional; Region: PRK12802
317655008272	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
317655008273	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
317655008274	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
317655008275	23S rRNA binding site [nucleotide binding]; other site
317655008276	L21 binding site [polypeptide binding]; other site
317655008277	L13 binding site [polypeptide binding]; other site
317655008278	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
317655008279	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
317655008280	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
317655008281	active site
317655008282	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
317655008283	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
317655008284	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
317655008285	active site
317655008286	NAD synthetase; Provisional; Region: PRK13981
317655008287	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
317655008288	multimer interface [polypeptide binding]; other site
317655008289	active site
317655008290	catalytic triad [active]
317655008291	protein interface 1 [polypeptide binding]; other site
317655008292	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
317655008293	homodimer interface [polypeptide binding]; other site
317655008294	NAD binding pocket [chemical binding]; other site
317655008295	ATP binding pocket [chemical binding]; other site
317655008296	Mg binding site [ion binding]; other site
317655008297	active-site loop [active]
317655008298	Predicted membrane protein [Function unknown]; Region: COG2259
317655008299	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
317655008300	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655008301	active site
317655008302	HIGH motif; other site
317655008303	nucleotide binding site [chemical binding]; other site
317655008304	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
317655008305	active site
317655008306	KMSKS motif; other site
317655008307	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
317655008308	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
317655008309	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
317655008310	MarR family; Region: MarR_2; pfam12802
317655008311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
317655008312	Coenzyme A binding pocket [chemical binding]; other site
317655008313	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
317655008314	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
317655008315	inhibitor-cofactor binding pocket; inhibition site
317655008316	pyridoxal 5'-phosphate binding site [chemical binding]; other site
317655008317	catalytic residue [active]
317655008318	Ectoine synthase; Region: Ectoine_synth; pfam06339
317655008319	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
317655008320	aspartate kinase; Validated; Region: PRK09181
317655008321	AAK_AK-Ectoine: Amino Acid Kinase Superfamily (AAK), AK-Ectoine; this CD includes the N-terminal catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway found in Methylomicrobium...; Region: AAK_AK-Ectoine; cd04248
317655008322	putative catalytic residues [active]
317655008323	putative nucleotide binding site [chemical binding]; other site
317655008324	putative aspartate binding site [chemical binding]; other site
317655008325	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
317655008326	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
317655008327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655008328	putative substrate translocation pore; other site
317655008329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655008330	metabolite-proton symporter; Region: 2A0106; TIGR00883
317655008331	putative substrate translocation pore; other site
317655008332	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
317655008333	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
317655008334	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
317655008335	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
317655008336	DNA binding residues [nucleotide binding]
317655008337	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
317655008338	active site
317655008339	catalytic triad [active]
317655008340	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
317655008341	DNA binding residues [nucleotide binding]
317655008342	dimerization interface [polypeptide binding]; other site
317655008343	Acyl transferase domain; Region: Acyl_transf_1; cl08282
317655008344	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
317655008345	tetramer interface [polypeptide binding]; other site
317655008346	TPP-binding site [chemical binding]; other site
317655008347	heterodimer interface [polypeptide binding]; other site
317655008348	phosphorylation loop region [posttranslational modification]
317655008349	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
317655008350	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
317655008351	PYR/PP interface [polypeptide binding]; other site
317655008352	dimer interface [polypeptide binding]; other site
317655008353	TPP binding site [chemical binding]; other site
317655008354	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
317655008355	MoxR-like ATPases [General function prediction only]; Region: COG0714
317655008356	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
317655008357	Walker A motif; other site
317655008358	ATP binding site [chemical binding]; other site
317655008359	Walker B motif; other site
317655008360	arginine finger; other site
317655008361	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
317655008362	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
317655008363	metal ion-dependent adhesion site (MIDAS); other site
317655008364	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
317655008365	Predicted membrane protein/domain [Function unknown]; Region: COG1714
317655008366	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
317655008367	putative FMN binding site [chemical binding]; other site
317655008368	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
317655008369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
317655008370	Mg2+ binding site [ion binding]; other site
317655008371	G-X-G motif; other site
317655008372	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
317655008373	anchoring element; other site
317655008374	dimer interface [polypeptide binding]; other site
317655008375	ATP binding site [chemical binding]; other site
317655008376	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
317655008377	active site
317655008378	putative metal-binding site [ion binding]; other site
317655008379	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
317655008380	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
317655008381	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
317655008382	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
317655008383	methionine sulfoxide reductase B; Provisional; Region: PRK00222
317655008384	SelR domain; Region: SelR; pfam01641
317655008385	Transglycosylase; Region: Transgly; pfam00912
317655008386	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
317655008387	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
317655008388	Protein of unknown function DUF45; Region: DUF45; pfam01863
317655008389	hypothetical protein; Provisional; Region: PRK05170
317655008390	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
317655008391	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
317655008392	Cu(I) binding site [ion binding]; other site
317655008393	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
317655008394	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
317655008395	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
317655008396	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
317655008397	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
317655008398	dimerization interface [polypeptide binding]; other site
317655008399	active site
317655008400	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
317655008401	homopentamer interface [polypeptide binding]; other site
317655008402	active site
317655008403	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
317655008404	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
317655008405	FMN binding site [chemical binding]; other site
317655008406	active site
317655008407	substrate binding site [chemical binding]; other site
317655008408	catalytic residue [active]
317655008409	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
317655008410	COQ9; Region: COQ9; pfam08511
317655008411	FeoA domain; Region: FeoA; pfam04023
317655008412	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
317655008413	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
317655008414	G1 box; other site
317655008415	GTP/Mg2+ binding site [chemical binding]; other site
317655008416	Switch I region; other site
317655008417	G2 box; other site
317655008418	G3 box; other site
317655008419	Switch II region; other site
317655008420	G4 box; other site
317655008421	G5 box; other site
317655008422	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
317655008423	Nucleoside recognition; Region: Gate; pfam07670
317655008424	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
317655008425	Nucleoside recognition; Region: Gate; pfam07670
317655008426	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
317655008427	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
317655008428	dimer interface [polypeptide binding]; other site
317655008429	ssDNA binding site [nucleotide binding]; other site
317655008430	tetramer (dimer of dimers) interface [polypeptide binding]; other site
317655008431	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
317655008432	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
317655008433	Lumazine binding domain; Region: Lum_binding; pfam00677
317655008434	Lumazine binding domain; Region: Lum_binding; pfam00677
317655008435	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
317655008436	active site
317655008437	Zn binding site [ion binding]; other site
317655008438	RibD C-terminal domain; Region: RibD_C; cl17279
317655008439	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655008440	active site
317655008441	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
317655008442	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
317655008443	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
317655008444	active site
317655008445	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
317655008446	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655008447	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655008448	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655008449	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
317655008450	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
317655008451	motif II; other site
317655008452	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
317655008453	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
317655008454	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
317655008455	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
317655008456	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
317655008457	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
317655008458	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
317655008459	Walker A/P-loop; other site
317655008460	ATP binding site [chemical binding]; other site
317655008461	Q-loop/lid; other site
317655008462	ABC transporter signature motif; other site
317655008463	Walker B; other site
317655008464	D-loop; other site
317655008465	H-loop/switch region; other site
317655008466	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
317655008467	active site
317655008468	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
317655008469	substrate binding site [chemical binding]; other site
317655008470	metal binding site [ion binding]; metal-binding site
317655008471	ATPase MipZ; Region: MipZ; pfam09140
317655008472	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
317655008473	P-loop; other site
317655008474	Magnesium ion binding site [ion binding]; other site
317655008475	Pantoate-beta-alanine ligase; Region: PanC; cd00560
317655008476	active site
317655008477	ATP-binding site [chemical binding]; other site
317655008478	pantoate-binding site; other site
317655008479	HXXH motif; other site
317655008480	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
317655008481	Sel1 repeat; Region: Sel1; cl02723
317655008482	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
317655008483	Protein of unknown function, DUF482; Region: DUF482; pfam04339
317655008484	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
317655008485	homotrimer interaction site [polypeptide binding]; other site
317655008486	putative active site [active]
317655008487	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
317655008488	Response regulator receiver domain; Region: Response_reg; pfam00072
317655008489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
317655008490	active site
317655008491	phosphorylation site [posttranslational modification]
317655008492	intermolecular recognition site; other site
317655008493	dimerization interface [polypeptide binding]; other site
317655008494	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008495	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655008496	active site
317655008497	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
317655008498	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
317655008499	Family description; Region: UvrD_C_2; pfam13538
317655008500	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
317655008501	DHH family; Region: DHH; pfam01368
317655008502	Predicted membrane protein [Function unknown]; Region: COG3428
317655008503	Bacterial PH domain; Region: DUF304; pfam03703
317655008504	Bacterial PH domain; Region: DUF304; pfam03703
317655008505	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
317655008506	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
317655008507	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
317655008508	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
317655008509	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
317655008510	Lipopolysaccharide-assembly; Region: LptE; pfam04390
317655008511	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
317655008512	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
317655008513	HIGH motif; other site
317655008514	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
317655008515	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655008516	active site
317655008517	KMSKS motif; other site
317655008518	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
317655008519	tRNA binding surface [nucleotide binding]; other site
317655008520	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
317655008521	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
317655008522	thiamine phosphate binding site [chemical binding]; other site
317655008523	active site
317655008524	pyrophosphate binding site [ion binding]; other site
317655008525	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
317655008526	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655008527	catalytic residue [active]
317655008528	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
317655008529	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
317655008530	ATP binding site [chemical binding]; other site
317655008531	putative Mg++ binding site [ion binding]; other site
317655008532	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
317655008533	nucleotide binding region [chemical binding]; other site
317655008534	ATP-binding site [chemical binding]; other site
317655008535	DEAD/H associated; Region: DEAD_assoc; pfam08494
317655008536	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
317655008537	catalytic motif [active]
317655008538	Catalytic residue [active]
317655008539	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
317655008540	catalytic motif [active]
317655008541	Catalytic residue [active]
317655008542	metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123
317655008543	active site
317655008544	metal binding site [ion binding]; metal-binding site
317655008545	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655008546	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008547	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008548	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
317655008549	Iron-sulfur protein interface; other site
317655008550	proximal quinone binding site [chemical binding]; other site
317655008551	SdhD (CybS) interface [polypeptide binding]; other site
317655008552	proximal heme binding site [chemical binding]; other site
317655008553	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
317655008554	putative SdhC subunit interface [polypeptide binding]; other site
317655008555	putative proximal heme binding site [chemical binding]; other site
317655008556	putative Iron-sulfur protein interface [polypeptide binding]; other site
317655008557	putative proximal quinone binding site; other site
317655008558	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
317655008559	L-aspartate oxidase; Provisional; Region: PRK06175
317655008560	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
317655008561	Transcriptional regulators [Transcription]; Region: PurR; COG1609
317655008562	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
317655008563	DNA binding site [nucleotide binding]
317655008564	domain linker motif; other site
317655008565	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
317655008566	putative dimerization interface [polypeptide binding]; other site
317655008567	putative ligand binding site [chemical binding]; other site
317655008568	hypothetical protein; Provisional; Region: PRK09273
317655008569	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
317655008570	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
317655008571	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
317655008572	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
317655008573	NADP binding site [chemical binding]; other site
317655008574	homodimer interface [polypeptide binding]; other site
317655008575	active site
317655008576	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
317655008577	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
317655008578	substrate binding site [chemical binding]; other site
317655008579	ATP binding site [chemical binding]; other site
317655008580	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
317655008581	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
317655008582	substrate binding pocket [chemical binding]; other site
317655008583	catalytic triad [active]
317655008584	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
317655008585	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
317655008586	Cupin domain; Region: Cupin_2; cl17218
317655008587	Pectate lyase; Region: Pec_lyase_C; cl01593
317655008588	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
317655008589	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008590	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008591	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
317655008592	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
317655008593	active site
317655008594	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
317655008595	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
317655008596	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
317655008597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655008598	Major Facilitator Superfamily; Region: MFS_1; pfam07690
317655008599	putative substrate translocation pore; other site
317655008600	glucuronate isomerase; Reviewed; Region: PRK02925
317655008601	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
317655008602	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
317655008603	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
317655008604	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
317655008605	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655008606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655008607	LysR substrate binding domain; Region: LysR_substrate; pfam03466
317655008608	dimerization interface [polypeptide binding]; other site
317655008609	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
317655008610	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
317655008611	tetrameric interface [polypeptide binding]; other site
317655008612	NAD binding site [chemical binding]; other site
317655008613	catalytic residues [active]
317655008614	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
317655008615	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
317655008616	homotrimer interaction site [polypeptide binding]; other site
317655008617	putative active site [active]
317655008618	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008619	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
317655008620	substrate binding pocket [chemical binding]; other site
317655008621	FAD binding site [chemical binding]; other site
317655008622	catalytic base [active]
317655008623	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
317655008624	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655008625	substrate binding site [chemical binding]; other site
317655008626	oxyanion hole (OAH) forming residues; other site
317655008627	trimer interface [polypeptide binding]; other site
317655008628	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
317655008629	enoyl-CoA hydratase; Provisional; Region: PRK05862
317655008630	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655008631	substrate binding site [chemical binding]; other site
317655008632	oxyanion hole (OAH) forming residues; other site
317655008633	trimer interface [polypeptide binding]; other site
317655008634	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
317655008635	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
317655008636	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
317655008637	dimer interface [polypeptide binding]; other site
317655008638	substrate binding site [chemical binding]; other site
317655008639	metal binding sites [ion binding]; metal-binding site
317655008640	Mechanosensitive ion channel; Region: MS_channel; pfam00924
317655008641	cystathionine beta-lyase; Provisional; Region: PRK09028
317655008642	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
317655008643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
317655008644	catalytic residue [active]
317655008645	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
317655008646	Chromate transporter; Region: Chromate_transp; pfam02417
317655008647	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
317655008648	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
317655008649	active site residue [active]
317655008650	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
317655008651	active site residue [active]
317655008652	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
317655008653	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655008654	active site
317655008655	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
317655008656	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
317655008657	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
317655008658	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
317655008659	substrate binding site [chemical binding]; other site
317655008660	oxyanion hole (OAH) forming residues; other site
317655008661	trimer interface [polypeptide binding]; other site
317655008662	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
317655008663	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
317655008664	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
317655008665	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
317655008666	Beta-lactamase; Region: Beta-lactamase; pfam00144
317655008667	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
317655008668	classical (c) SDRs; Region: SDR_c; cd05233
317655008669	NAD(P) binding site [chemical binding]; other site
317655008670	active site
317655008671	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
317655008672	classical (c) SDRs; Region: SDR_c; cd05233
317655008673	NAD(P) binding site [chemical binding]; other site
317655008674	active site
317655008675	Phosphotransferase enzyme family; Region: APH; pfam01636
317655008676	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
317655008677	putative active site [active]
317655008678	putative substrate binding site [chemical binding]; other site
317655008679	ATP binding site [chemical binding]; other site
317655008680	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
317655008681	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
317655008682	NAD binding site [chemical binding]; other site
317655008683	catalytic Zn binding site [ion binding]; other site
317655008684	substrate binding site [chemical binding]; other site
317655008685	structural Zn binding site [ion binding]; other site
317655008686	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008687	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655008688	active site
317655008689	MFS/sugar transport protein; Region: MFS_2; pfam13347
317655008690	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
317655008691	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
317655008692	classical (c) SDRs; Region: SDR_c; cd05233
317655008693	NAD(P) binding site [chemical binding]; other site
317655008694	active site
317655008695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655008696	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
317655008697	active site
317655008698	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008699	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
317655008700	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
317655008701	active site
317655008702	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
317655008703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655008704	NAD(P) binding site [chemical binding]; other site
317655008705	active site
317655008706	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
317655008707	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
317655008708	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
317655008709	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
317655008710	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
317655008711	active site
317655008712	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
317655008713	active site
317655008714	HIGH motif; other site
317655008715	nucleotide binding site [chemical binding]; other site
317655008716	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
317655008717	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
317655008718	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
317655008719	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
317655008720	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
317655008721	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
317655008722	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
317655008723	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
317655008724	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
317655008725	Beta/Gamma crystallin; Region: Crystall; cl02528
317655008726	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
317655008727	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
317655008728	Nucleoside recognition; Region: Gate; pfam07670
317655008729	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
317655008730	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
317655008731	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
317655008732	feedback inhibition sensing region; other site
317655008733	homohexameric interface [polypeptide binding]; other site
317655008734	nucleotide binding site [chemical binding]; other site
317655008735	N-acetyl-L-glutamate binding site [chemical binding]; other site
317655008736	YGGT family; Region: YGGT; pfam02325
317655008737	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
317655008738	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
317655008739	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
317655008740	homodimer interface [polypeptide binding]; other site
317655008741	NADP binding site [chemical binding]; other site
317655008742	substrate binding site [chemical binding]; other site
317655008743	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
317655008744	putative outer membrane lipoprotein; Provisional; Region: PRK10510
317655008745	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
317655008746	ligand binding site [chemical binding]; other site
317655008747	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
317655008748	Domain of unknown function DUF21; Region: DUF21; pfam01595
317655008749	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
317655008750	Transporter associated domain; Region: CorC_HlyC; smart01091
317655008751	Uncharacterized conserved protein [Function unknown]; Region: COG3743
317655008752	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
317655008753	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
317655008754	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
317655008755	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
317655008756	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
317655008757	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
317655008758	generic binding surface II; other site
317655008759	generic binding surface I; other site
317655008760	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3908
317655008761	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
317655008762	Peptidase family M23; Region: Peptidase_M23; pfam01551
317655008763	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
317655008764	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008765	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008766	TPR repeat; Region: TPR_11; pfam13414
317655008767	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
317655008768	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
317655008769	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
317655008770	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
317655008771	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
317655008772	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
317655008773	HlyD family secretion protein; Region: HlyD_3; pfam13437
317655008774	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
317655008775	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655008776	putative substrate translocation pore; other site
317655008777	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
317655008778	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
317655008779	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655008780	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655008781	ABC transporter; Region: ABC_tran_2; pfam12848
317655008782	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
317655008783	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
317655008784	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
317655008785	dimer interface [polypeptide binding]; other site
317655008786	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
317655008787	active site
317655008788	Fe binding site [ion binding]; other site
317655008789	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
317655008790	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
317655008791	Zn binding site [ion binding]; other site
317655008792	Bacterial transcriptional activator domain; Region: BTAD; smart01043
317655008793	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
317655008794	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
317655008795	purine monophosphate binding site [chemical binding]; other site
317655008796	dimer interface [polypeptide binding]; other site
317655008797	putative catalytic residues [active]
317655008798	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
317655008799	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
317655008800	Phytase; Region: Phytase; cl17685
317655008801	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
317655008802	N-terminal plug; other site
317655008803	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
317655008804	ligand-binding site [chemical binding]; other site
317655008805	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
317655008806	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
317655008807	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
317655008808	substrate binding site [chemical binding]; other site
317655008809	hexamer interface [polypeptide binding]; other site
317655008810	metal binding site [ion binding]; metal-binding site
317655008811	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
317655008812	AAA domain; Region: AAA_28; pfam13521
317655008813	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
317655008814	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
317655008815	active site lid residues [active]
317655008816	substrate binding pocket [chemical binding]; other site
317655008817	catalytic residues [active]
317655008818	substrate-Mg2+ binding site; other site
317655008819	aspartate-rich region 1; other site
317655008820	aspartate-rich region 2; other site
317655008821	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
317655008822	phytoene desaturase; Region: crtI_fam; TIGR02734
317655008823	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
317655008824	hydroxyglutarate oxidase; Provisional; Region: PRK11728
317655008825	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
317655008826	lycopene cyclase; Region: lycopene_cycl; TIGR01789
317655008827	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
317655008828	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
317655008829	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
317655008830	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
317655008831	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
317655008832	putative active site [active]
317655008833	catalytic triad [active]
317655008834	putative dimer interface [polypeptide binding]; other site
317655008835	S-adenosylmethionine synthetase; Validated; Region: PRK05250
317655008836	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
317655008837	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
317655008838	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
317655008839	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
317655008840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
317655008841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
317655008842	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
317655008843	putative effector binding pocket; other site
317655008844	putative dimerization interface [polypeptide binding]; other site
317655008845	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
317655008846	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
317655008847	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
317655008848	dimer interface [polypeptide binding]; other site
317655008849	active site
317655008850	CoA binding pocket [chemical binding]; other site
317655008851	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
317655008852	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
317655008853	substrate binding site [chemical binding]; other site
317655008854	glutamase interaction surface [polypeptide binding]; other site
317655008855	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
317655008856	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
317655008857	catalytic residues [active]
317655008858	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
317655008859	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
317655008860	putative active site [active]
317655008861	oxyanion strand; other site
317655008862	catalytic triad [active]
317655008863	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
317655008864	putative active site pocket [active]
317655008865	4-fold oligomerization interface [polypeptide binding]; other site
317655008866	metal binding residues [ion binding]; metal-binding site
317655008867	3-fold/trimer interface [polypeptide binding]; other site
317655008868	Stringent starvation protein B; Region: SspB; pfam04386
317655008869	fumarate hydratase; Reviewed; Region: fumC; PRK00485
317655008870	Class II fumarases; Region: Fumarase_classII; cd01362
317655008871	active site
317655008872	tetramer interface [polypeptide binding]; other site
317655008873	hypothetical protein; Provisional; Region: PRK00944
317655008874	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
317655008875	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
317655008876	catalytic site [active]
317655008877	G-X2-G-X-G-K; other site
317655008878	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
317655008879	active site
317655008880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
317655008881	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
317655008882	NAD(P) binding site [chemical binding]; other site
317655008883	active site
317655008884	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
317655008885	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
317655008886	dimer interface [polypeptide binding]; other site
317655008887	active site
317655008888	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
317655008889	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
317655008890	active site
317655008891	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
317655008892	Strictosidine synthase; Region: Str_synth; pfam03088
317655008893	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
317655008894	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
317655008895	active site
317655008896	Zn binding site [ion binding]; other site
317655008897	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
317655008898	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
317655008899	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
317655008900	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
317655008901	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
317655008902	ligand binding site [chemical binding]; other site
317655008903	flexible hinge region; other site
317655008904	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
317655008905	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
317655008906	[2Fe-2S] cluster binding site [ion binding]; other site
317655008907	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
317655008908	alpha subunit interface [polypeptide binding]; other site
317655008909	active site
317655008910	substrate binding site [chemical binding]; other site
317655008911	Fe binding site [ion binding]; other site
317655008912	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
317655008913	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
317655008914	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
317655008915	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
317655008916	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
317655008917	Tetratricopeptide repeat; Region: TPR_16; pfam13432
317655008918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655008919	TPR motif; other site
317655008920	binding surface
317655008921	Tetratricopeptide repeat; Region: TPR_16; pfam13432
317655008922	Tetratricopeptide repeat; Region: TPR_16; pfam13432
317655008923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655008924	TPR motif; other site
317655008925	binding surface
317655008926	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
317655008927	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
317655008928	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
317655008929	Peptidase family M48; Region: Peptidase_M48; cl12018
317655008930	TPR repeat; Region: TPR_11; pfam13414
317655008931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
317655008932	TPR motif; other site
317655008933	binding surface
317655008934	TPR repeat; Region: TPR_11; pfam13414
317655008935	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
317655008936	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
317655008937	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
317655008938	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
317655008939	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
317655008940	active site
317655008941	metal binding site [ion binding]; metal-binding site
317655008942	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
317655008943	FAD binding domain; Region: FAD_binding_4; pfam01565
317655008944	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
317655008945	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
317655008946	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
317655008947	dimer interface [polypeptide binding]; other site
317655008948	active site
317655008949	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
317655008950	substrate binding site [chemical binding]; other site
317655008951	catalytic residue [active]
317655008952	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
317655008953	Transglycosylase; Region: Transgly; pfam00912
317655008954	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
317655008955	peptide chain release factor 2; Validated; Region: prfB; PRK00578
317655008956	This domain is found in peptide chain release factors; Region: PCRF; smart00937
317655008957	RF-1 domain; Region: RF-1; pfam00472
317655008958	Methyltransferase domain; Region: Methyltransf_31; pfam13847
317655008959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655008960	S-adenosylmethionine binding site [chemical binding]; other site
317655008961	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
317655008962	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
317655008963	ATP binding site [chemical binding]; other site
317655008964	substrate interface [chemical binding]; other site
317655008965	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
317655008966	trimer interface [polypeptide binding]; other site
317655008967	active site
317655008968	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
317655008969	Flavoprotein; Region: Flavoprotein; pfam02441
317655008970	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
317655008971	CcdB protein; Region: CcdB; cl03380
317655008972	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
317655008973	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
317655008974	ABC1 family; Region: ABC1; pfam03109
317655008975	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
317655008976	active site
317655008977	ATP binding site [chemical binding]; other site
317655008978	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
317655008979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
317655008980	S-adenosylmethionine binding site [chemical binding]; other site
317655008981	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
317655008982	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
317655008983	DNA binding site [nucleotide binding]
317655008984	catalytic residue [active]
317655008985	H2TH interface [polypeptide binding]; other site
317655008986	putative catalytic residues [active]
317655008987	turnover-facilitating residue; other site
317655008988	intercalation triad [nucleotide binding]; other site
317655008989	8OG recognition residue [nucleotide binding]; other site
317655008990	putative reading head residues; other site
317655008991	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
317655008992	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239