-- dump date 20140620_072332 -- class Genbank::misc_feature -- table misc_feature_note -- id note 760011000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 760011000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 760011000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000004 Walker A motif; other site 760011000005 ATP binding site [chemical binding]; other site 760011000006 Walker B motif; other site 760011000007 arginine finger; other site 760011000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 760011000009 DnaA box-binding interface [nucleotide binding]; other site 760011000010 DNA polymerase III subunit beta; Provisional; Region: PRK14940 760011000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 760011000012 putative DNA binding surface [nucleotide binding]; other site 760011000013 dimer interface [polypeptide binding]; other site 760011000014 beta-clamp/clamp loader binding surface; other site 760011000015 beta-clamp/translesion DNA polymerase binding surface; other site 760011000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 760011000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011000018 Walker A/P-loop; other site 760011000019 ATP binding site [chemical binding]; other site 760011000020 Q-loop/lid; other site 760011000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011000022 ABC transporter signature motif; other site 760011000023 Walker B; other site 760011000024 D-loop; other site 760011000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 760011000026 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 760011000027 Ribonuclease P; Region: Ribonuclease_P; pfam00825 760011000028 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 760011000029 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 760011000030 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 760011000031 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 760011000032 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 760011000033 G-X-X-G motif; other site 760011000034 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 760011000035 RxxxH motif; other site 760011000036 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 760011000037 glucose-6-phosphate isomerase; Provisional; Region: PRK04190 760011000038 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 760011000039 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 760011000040 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 760011000041 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760011000042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011000043 DNA-binding site [nucleotide binding]; DNA binding site 760011000044 UTRA domain; Region: UTRA; pfam07702 760011000045 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 760011000046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000047 Walker A motif; other site 760011000048 ATP binding site [chemical binding]; other site 760011000049 Walker B motif; other site 760011000050 arginine finger; other site 760011000051 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760011000052 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 760011000053 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011000054 putative ligand binding site [chemical binding]; other site 760011000055 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011000056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011000057 Walker A/P-loop; other site 760011000058 ATP binding site [chemical binding]; other site 760011000059 Q-loop/lid; other site 760011000060 ABC transporter signature motif; other site 760011000061 Walker B; other site 760011000062 D-loop; other site 760011000063 H-loop/switch region; other site 760011000064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011000065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000066 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011000067 TM-ABC transporter signature motif; other site 760011000068 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 760011000069 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 760011000070 N- and C-terminal domain interface [polypeptide binding]; other site 760011000071 active site 760011000072 MgATP binding site [chemical binding]; other site 760011000073 catalytic site [active] 760011000074 metal binding site [ion binding]; metal-binding site 760011000075 xylulose binding site [chemical binding]; other site 760011000076 putative homodimer interface [polypeptide binding]; other site 760011000077 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 760011000078 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 760011000079 N- and C-terminal domain interface [polypeptide binding]; other site 760011000080 active site 760011000081 MgATP binding site [chemical binding]; other site 760011000082 catalytic site [active] 760011000083 metal binding site [ion binding]; metal-binding site 760011000084 xylulose binding site [chemical binding]; other site 760011000085 putative homodimer interface [polypeptide binding]; other site 760011000086 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760011000087 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760011000088 active site 760011000089 catalytic tetrad [active] 760011000090 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760011000091 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 760011000092 substrate binding site [chemical binding]; other site 760011000093 dimer interface [polypeptide binding]; other site 760011000094 ATP binding site [chemical binding]; other site 760011000095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760011000096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011000097 DNA-binding site [nucleotide binding]; DNA binding site 760011000098 UTRA domain; Region: UTRA; pfam07702 760011000099 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 760011000100 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 760011000101 putative ligand binding site [chemical binding]; other site 760011000102 putative NAD binding site [chemical binding]; other site 760011000103 catalytic site [active] 760011000104 S-adenosylmethionine synthetase; Validated; Region: PRK05250 760011000105 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 760011000106 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 760011000107 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 760011000108 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 760011000109 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 760011000110 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 760011000111 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760011000112 substrate binding site [chemical binding]; other site 760011000113 ATP binding site [chemical binding]; other site 760011000114 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 760011000115 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 760011000116 hinge; other site 760011000117 active site 760011000118 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760011000119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000120 Walker A motif; other site 760011000121 ATP binding site [chemical binding]; other site 760011000122 Walker B motif; other site 760011000123 arginine finger; other site 760011000124 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760011000125 metal binding site [ion binding]; metal-binding site 760011000126 Uncharacterized conserved protein [Function unknown]; Region: COG1739 760011000127 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 760011000128 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 760011000129 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 760011000130 putative active site [active] 760011000131 nucleotide binding site [chemical binding]; other site 760011000132 nudix motif; other site 760011000133 putative metal binding site [ion binding]; other site 760011000134 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 760011000135 nucleotide binding site [chemical binding]; other site 760011000136 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 760011000137 intersubunit interface [polypeptide binding]; other site 760011000138 active site 760011000139 catalytic residue [active] 760011000140 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 760011000141 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760011000142 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760011000143 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 760011000144 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 760011000145 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 760011000146 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 760011000147 active site 760011000148 intersubunit interface [polypeptide binding]; other site 760011000149 catalytic residue [active] 760011000150 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760011000151 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 760011000152 substrate binding site [chemical binding]; other site 760011000153 ATP binding site [chemical binding]; other site 760011000154 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011000155 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000156 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000157 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 760011000158 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 760011000159 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 760011000160 DNA binding site [nucleotide binding] 760011000161 active site 760011000162 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 760011000163 Transcriptional regulator [Transcription]; Region: IclR; COG1414 760011000164 Bacterial transcriptional regulator; Region: IclR; pfam01614 760011000165 Glucuronate isomerase; Region: UxaC; pfam02614 760011000166 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 760011000167 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 760011000168 galactarate dehydratase; Region: galactar-dH20; TIGR03248 760011000169 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 760011000170 altronate oxidoreductase; Provisional; Region: PRK03643 760011000171 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 760011000172 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 760011000173 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 760011000174 Sodium Bile acid symporter family; Region: SBF; cl17470 760011000175 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000176 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000177 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000178 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000179 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000180 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000181 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000182 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000183 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000184 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000185 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000186 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011000187 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000188 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000189 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 760011000190 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000192 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000193 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000194 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000195 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000196 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000197 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000198 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000199 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000200 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000201 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000202 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011000203 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000204 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000205 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000206 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000207 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000208 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000209 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000210 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000211 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000212 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000213 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000214 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000215 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011000216 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 760011000217 ligand binding site [chemical binding]; other site 760011000218 dimerization interface [polypeptide binding]; other site 760011000219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011000220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000221 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000223 dimer interface [polypeptide binding]; other site 760011000224 conserved gate region; other site 760011000225 putative PBP binding loops; other site 760011000226 ABC-ATPase subunit interface; other site 760011000227 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000229 dimer interface [polypeptide binding]; other site 760011000230 conserved gate region; other site 760011000231 putative PBP binding loops; other site 760011000232 ABC-ATPase subunit interface; other site 760011000233 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011000234 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 760011000235 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000236 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000237 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000238 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000239 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000240 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000246 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011000247 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000248 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000249 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000250 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000251 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000252 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000253 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000254 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000255 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000256 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000257 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000258 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000259 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000260 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 760011000261 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 760011000262 ligand binding site [chemical binding]; other site 760011000263 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 760011000264 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011000265 Walker A/P-loop; other site 760011000266 ATP binding site [chemical binding]; other site 760011000267 Q-loop/lid; other site 760011000268 ABC transporter signature motif; other site 760011000269 Walker B; other site 760011000270 D-loop; other site 760011000271 H-loop/switch region; other site 760011000272 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011000273 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000274 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760011000275 TM-ABC transporter signature motif; other site 760011000276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000277 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760011000278 TM-ABC transporter signature motif; other site 760011000279 purine nucleoside phosphorylase; Provisional; Region: PRK08202 760011000280 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 760011000281 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 760011000282 classical (c) SDRs; Region: SDR_c; cd05233 760011000283 NAD(P) binding site [chemical binding]; other site 760011000284 active site 760011000285 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760011000286 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760011000287 active site 760011000288 metal binding site [ion binding]; metal-binding site 760011000289 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 760011000290 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 760011000291 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760011000292 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011000293 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 760011000294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011000295 Walker A/P-loop; other site 760011000296 ATP binding site [chemical binding]; other site 760011000297 Q-loop/lid; other site 760011000298 ABC transporter signature motif; other site 760011000299 Walker B; other site 760011000300 D-loop; other site 760011000301 H-loop/switch region; other site 760011000302 Transcriptional regulators [Transcription]; Region: FadR; COG2186 760011000303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011000304 DNA-binding site [nucleotide binding]; DNA binding site 760011000305 FCD domain; Region: FCD; pfam07729 760011000306 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 760011000307 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 760011000308 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 760011000309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011000310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011000311 DNA binding site [nucleotide binding] 760011000312 domain linker motif; other site 760011000313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011000314 dimerization interface [polypeptide binding]; other site 760011000315 ligand binding site [chemical binding]; other site 760011000316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760011000317 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760011000318 ligand binding site [chemical binding]; other site 760011000319 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000320 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011000321 TM-ABC transporter signature motif; other site 760011000322 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011000323 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011000324 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760011000325 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011000326 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011000327 Walker A/P-loop; other site 760011000328 ATP binding site [chemical binding]; other site 760011000329 Q-loop/lid; other site 760011000330 ABC transporter signature motif; other site 760011000331 Walker B; other site 760011000332 D-loop; other site 760011000333 H-loop/switch region; other site 760011000334 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011000335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011000336 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011000337 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760011000338 KduI/IolB family; Region: KduI; pfam04962 760011000339 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 760011000340 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 760011000341 PYR/PP interface [polypeptide binding]; other site 760011000342 dimer interface [polypeptide binding]; other site 760011000343 TPP binding site [chemical binding]; other site 760011000344 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 760011000345 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 760011000346 TPP-binding site [chemical binding]; other site 760011000347 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760011000348 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 760011000349 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 760011000350 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 760011000351 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 760011000352 Phosphoglycerate kinase; Region: PGK; pfam00162 760011000353 substrate binding site [chemical binding]; other site 760011000354 hinge regions; other site 760011000355 ADP binding site [chemical binding]; other site 760011000356 catalytic site [active] 760011000357 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 760011000358 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 760011000359 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 760011000360 HIGH motif; other site 760011000361 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760011000362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011000363 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011000364 active site 760011000365 KMSKS motif; other site 760011000366 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 760011000367 tRNA binding surface [nucleotide binding]; other site 760011000368 Fic family protein [Function unknown]; Region: COG3177 760011000369 Fic/DOC family; Region: Fic; pfam02661 760011000370 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 760011000371 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 760011000372 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 760011000373 FtsJ-like methyltransferase; Region: FtsJ; cl17430 760011000374 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 760011000375 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 760011000376 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 760011000377 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011000378 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760011000379 nucleotide binding site [chemical binding]; other site 760011000380 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 760011000381 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 760011000382 dimer interface [polypeptide binding]; other site 760011000383 active site 760011000384 glycine loop; other site 760011000385 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760011000386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011000387 DNA-binding site [nucleotide binding]; DNA binding site 760011000388 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760011000389 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760011000390 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760011000391 ligand binding site [chemical binding]; other site 760011000392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011000393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011000394 Walker A/P-loop; other site 760011000395 ATP binding site [chemical binding]; other site 760011000396 Q-loop/lid; other site 760011000397 ABC transporter signature motif; other site 760011000398 Walker B; other site 760011000399 D-loop; other site 760011000400 H-loop/switch region; other site 760011000401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011000402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011000404 TM-ABC transporter signature motif; other site 760011000405 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000406 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011000407 TM-ABC transporter signature motif; other site 760011000408 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011000409 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011000410 DNA binding site [nucleotide binding] 760011000411 domain linker motif; other site 760011000412 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011000413 ligand binding site [chemical binding]; other site 760011000414 dimerization interface [polypeptide binding]; other site 760011000415 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011000416 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011000417 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760011000418 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 760011000419 4Fe-4S binding domain; Region: Fer4; cl02805 760011000420 4Fe-4S binding domain; Region: Fer4; pfam00037 760011000421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 760011000422 FeS/SAM binding site; other site 760011000423 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 760011000424 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 760011000425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011000427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000428 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011000429 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760011000430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011000431 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 760011000432 TM-ABC transporter signature motif; other site 760011000433 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 760011000434 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 760011000435 TM-ABC transporter signature motif; other site 760011000436 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 760011000437 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 760011000438 Walker A/P-loop; other site 760011000439 ATP binding site [chemical binding]; other site 760011000440 Q-loop/lid; other site 760011000441 ABC transporter signature motif; other site 760011000442 Walker B; other site 760011000443 D-loop; other site 760011000444 H-loop/switch region; other site 760011000445 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 760011000446 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 760011000447 Walker A/P-loop; other site 760011000448 ATP binding site [chemical binding]; other site 760011000449 Q-loop/lid; other site 760011000450 ABC transporter signature motif; other site 760011000451 Walker B; other site 760011000452 D-loop; other site 760011000453 H-loop/switch region; other site 760011000454 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 760011000455 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 760011000456 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 760011000457 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 760011000458 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 760011000459 shikimate binding site; other site 760011000460 NAD(P) binding site [chemical binding]; other site 760011000461 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 760011000462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011000463 FeS/SAM binding site; other site 760011000464 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 760011000465 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 760011000466 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 760011000467 active site 760011000468 purine riboside binding site [chemical binding]; other site 760011000469 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 760011000470 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 760011000471 prolyl-tRNA synthetase; Provisional; Region: PRK09194 760011000472 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760011000473 motif 1; other site 760011000474 dimer interface [polypeptide binding]; other site 760011000475 active site 760011000476 motif 2; other site 760011000477 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 760011000478 putative deacylase active site [active] 760011000479 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760011000480 active site 760011000481 motif 3; other site 760011000482 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 760011000483 anticodon binding site; other site 760011000484 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 760011000485 intersubunit interface [polypeptide binding]; other site 760011000486 active site 760011000487 Zn2+ binding site [ion binding]; other site 760011000488 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 760011000489 TPP-binding site [chemical binding]; other site 760011000490 dimer interface [polypeptide binding]; other site 760011000491 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 760011000492 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 760011000493 PYR/PP interface [polypeptide binding]; other site 760011000494 dimer interface [polypeptide binding]; other site 760011000495 TPP binding site [chemical binding]; other site 760011000496 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760011000497 OsmC-like protein; Region: OsmC; pfam02566 760011000498 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 760011000499 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 760011000500 dimer interface [polypeptide binding]; other site 760011000501 anticodon binding site; other site 760011000502 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 760011000503 homodimer interface [polypeptide binding]; other site 760011000504 motif 1; other site 760011000505 active site 760011000506 motif 2; other site 760011000507 GAD domain; Region: GAD; pfam02938 760011000508 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760011000509 active site 760011000510 motif 3; other site 760011000511 Virulence protein [General function prediction only]; Region: COG3943 760011000512 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 760011000513 Divergent AAA domain; Region: AAA_4; pfam04326 760011000514 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760011000515 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760011000516 non-specific DNA interactions [nucleotide binding]; other site 760011000517 DNA binding site [nucleotide binding] 760011000518 sequence specific DNA binding site [nucleotide binding]; other site 760011000519 putative cAMP binding site [chemical binding]; other site 760011000520 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 760011000521 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 760011000522 putative ADP-ribose binding site [chemical binding]; other site 760011000523 putative active site [active] 760011000524 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 760011000525 Uncharacterized conserved protein [Function unknown]; Region: COG3595 760011000526 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 760011000527 phage shock protein C; Region: phageshock_pspC; TIGR02978 760011000528 PspC domain; Region: PspC; pfam04024 760011000529 phage shock protein A; Region: phageshock_pspA; TIGR02977 760011000530 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 760011000531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000532 Walker A motif; other site 760011000533 ATP binding site [chemical binding]; other site 760011000534 Walker B motif; other site 760011000535 arginine finger; other site 760011000536 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760011000537 PspC domain; Region: PspC; pfam04024 760011000538 phage shock protein A; Region: phageshock_pspA; TIGR02977 760011000539 Predicted methyltransferases [General function prediction only]; Region: COG0313 760011000540 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 760011000541 putative SAM binding site [chemical binding]; other site 760011000542 putative homodimer interface [polypeptide binding]; other site 760011000543 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760011000544 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 760011000545 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 760011000546 Uncharacterized conserved protein [Function unknown]; Region: COG0327 760011000547 dinuclear metal center protein, YbgI/SA1388 family; Region: YbgI_SA1388; TIGR00486 760011000548 lipoprotein signal peptidase; Provisional; Region: PRK14787 760011000549 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 760011000550 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 760011000551 active site 760011000552 DinB superfamily; Region: DinB_2; pfam12867 760011000553 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 760011000554 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 760011000555 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760011000556 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 760011000557 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760011000558 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760011000559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000560 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 760011000561 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 760011000562 N- and C-terminal domain interface [polypeptide binding]; other site 760011000563 D-xylulose kinase; Region: XylB; TIGR01312 760011000564 active site 760011000565 MgATP binding site [chemical binding]; other site 760011000566 catalytic site [active] 760011000567 metal binding site [ion binding]; metal-binding site 760011000568 xylulose binding site [chemical binding]; other site 760011000569 putative homodimer interface [polypeptide binding]; other site 760011000570 xylose isomerase; Provisional; Region: PRK05474 760011000571 xylose isomerase; Region: xylose_isom_A; TIGR02630 760011000572 putative pectinesterase; Region: PLN02432; cl01911 760011000573 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 760011000574 dimer interface [polypeptide binding]; other site 760011000575 Alkaline phosphatase homologues; Region: alkPPc; smart00098 760011000576 active site 760011000577 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 760011000578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760011000579 Walker A/P-loop; other site 760011000580 ATP binding site [chemical binding]; other site 760011000581 Q-loop/lid; other site 760011000582 ABC transporter signature motif; other site 760011000583 Walker B; other site 760011000584 D-loop; other site 760011000585 H-loop/switch region; other site 760011000586 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760011000587 FtsX-like permease family; Region: FtsX; pfam02687 760011000588 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 760011000589 Domain of unknown function DUF21; Region: DUF21; pfam01595 760011000590 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 760011000591 Transporter associated domain; Region: CorC_HlyC; pfam03471 760011000592 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 760011000593 Phosphate transporter family; Region: PHO4; pfam01384 760011000594 Predicted membrane protein [Function unknown]; Region: COG2510 760011000595 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 760011000596 Predicted membrane protein [Function unknown]; Region: COG2510 760011000597 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 760011000598 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 760011000599 Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159 760011000600 putative homodimer interface [polypeptide binding]; other site 760011000601 putative homotetramer interface [polypeptide binding]; other site 760011000602 putative allosteric switch controlling residues; other site 760011000603 putative metal binding site [ion binding]; other site 760011000604 putative homodimer-homodimer interface [polypeptide binding]; other site 760011000605 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000606 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000607 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000608 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000609 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000610 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000611 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000612 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000613 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000614 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000615 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000616 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 760011000617 putative acyl-acceptor binding pocket; other site 760011000618 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011000619 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011000620 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760011000621 Walker A/P-loop; other site 760011000622 ATP binding site [chemical binding]; other site 760011000623 Q-loop/lid; other site 760011000624 ABC transporter signature motif; other site 760011000625 Walker B; other site 760011000626 D-loop; other site 760011000627 H-loop/switch region; other site 760011000628 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011000629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011000630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011000631 Walker A/P-loop; other site 760011000632 ATP binding site [chemical binding]; other site 760011000633 Q-loop/lid; other site 760011000634 ABC transporter signature motif; other site 760011000635 Walker B; other site 760011000636 D-loop; other site 760011000637 H-loop/switch region; other site 760011000638 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011000639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011000640 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011000641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000642 dimer interface [polypeptide binding]; other site 760011000643 conserved gate region; other site 760011000644 putative PBP binding loops; other site 760011000645 ABC-ATPase subunit interface; other site 760011000646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000648 dimer interface [polypeptide binding]; other site 760011000649 conserved gate region; other site 760011000650 putative PBP binding loops; other site 760011000651 ABC-ATPase subunit interface; other site 760011000652 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 760011000653 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011000654 active site 760011000655 motif I; other site 760011000656 motif II; other site 760011000657 Response regulator receiver domain; Region: Response_reg; pfam00072 760011000658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011000659 active site 760011000660 phosphorylation site [posttranslational modification] 760011000661 intermolecular recognition site; other site 760011000662 dimerization interface [polypeptide binding]; other site 760011000663 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760011000664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000666 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760011000667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760011000668 dimerization interface [polypeptide binding]; other site 760011000669 Histidine kinase; Region: His_kinase; pfam06580 760011000670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011000671 ATP binding site [chemical binding]; other site 760011000672 Mg2+ binding site [ion binding]; other site 760011000673 G-X-G motif; other site 760011000674 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 760011000675 sequence-specific DNA binding site [nucleotide binding]; other site 760011000676 salt bridge; other site 760011000677 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 760011000678 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760011000679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760011000680 ATP binding site [chemical binding]; other site 760011000681 putative Mg++ binding site [ion binding]; other site 760011000682 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 760011000683 Fic family protein [Function unknown]; Region: COG3177 760011000684 Fic/DOC family; Region: Fic; pfam02661 760011000685 HipA-like C-terminal domain; Region: HipA_C; pfam07804 760011000686 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 760011000687 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 760011000688 Part of AAA domain; Region: AAA_19; pfam13245 760011000689 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 760011000690 Fic family protein [Function unknown]; Region: COG3177 760011000691 Fic/DOC family; Region: Fic; pfam02661 760011000692 HipA-like C-terminal domain; Region: HipA_C; pfam07804 760011000693 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 760011000694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760011000695 non-specific DNA binding site [nucleotide binding]; other site 760011000696 salt bridge; other site 760011000697 sequence-specific DNA binding site [nucleotide binding]; other site 760011000698 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011000699 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 760011000700 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011000701 homodimer interface [polypeptide binding]; other site 760011000702 catalytic residue [active] 760011000703 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 760011000704 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 760011000705 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 760011000706 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 760011000707 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 760011000708 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 760011000709 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 760011000710 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 760011000711 Integral membrane protein DUF92; Region: DUF92; pfam01940 760011000712 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 760011000713 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 760011000714 ring oligomerisation interface [polypeptide binding]; other site 760011000715 ATP/Mg binding site [chemical binding]; other site 760011000716 stacking interactions; other site 760011000717 hinge regions; other site 760011000718 Preprotein translocase subunit; Region: YajC; pfam02699 760011000719 protein-export membrane protein SecD; Region: secD; TIGR01129 760011000720 Protein export membrane protein; Region: SecD_SecF; cl14618 760011000721 LytB protein; Region: LYTB; cl00507 760011000722 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 760011000723 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 760011000724 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 760011000725 CoA binding domain; Region: CoA_binding; pfam02629 760011000726 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 760011000727 GAF domain; Region: GAF_2; pfam13185 760011000728 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 760011000729 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760011000730 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 760011000731 active site 760011000732 dimer interface [polypeptide binding]; other site 760011000733 motif 1; other site 760011000734 motif 2; other site 760011000735 motif 3; other site 760011000736 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 760011000737 anticodon binding site; other site 760011000738 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 760011000739 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 760011000740 active site 760011000741 Zn binding site [ion binding]; other site 760011000742 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 760011000743 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 760011000744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011000745 active site 760011000746 motif I; other site 760011000747 motif II; other site 760011000748 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 760011000749 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 760011000750 ABC-ATPase subunit interface; other site 760011000751 dimer interface [polypeptide binding]; other site 760011000752 putative PBP binding regions; other site 760011000753 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760011000754 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 760011000755 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 760011000756 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 760011000757 Walker A/P-loop; other site 760011000758 ATP binding site [chemical binding]; other site 760011000759 Q-loop/lid; other site 760011000760 ABC transporter signature motif; other site 760011000761 Walker B; other site 760011000762 D-loop; other site 760011000763 H-loop/switch region; other site 760011000764 NIL domain; Region: NIL; pfam09383 760011000765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000766 ABC-ATPase subunit interface; other site 760011000767 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 760011000768 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 760011000769 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 760011000770 RmuC family; Region: RmuC; pfam02646 760011000771 ornithine carbamoyltransferase; Validated; Region: PRK02102 760011000772 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760011000773 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760011000774 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000775 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000776 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000777 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000778 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000779 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000780 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000781 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000782 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000783 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000784 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000785 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000786 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000787 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000788 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000789 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000790 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000791 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000792 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000793 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000794 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 760011000795 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 760011000796 dimerization interface [polypeptide binding]; other site 760011000797 DPS ferroxidase diiron center [ion binding]; other site 760011000798 ion pore; other site 760011000799 GAF domain; Region: GAF; pfam01590 760011000800 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 760011000801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000802 Walker A motif; other site 760011000803 ATP binding site [chemical binding]; other site 760011000804 Walker B motif; other site 760011000805 arginine finger; other site 760011000806 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 760011000807 Clp amino terminal domain; Region: Clp_N; pfam02861 760011000808 Clp amino terminal domain; Region: Clp_N; pfam02861 760011000809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000810 Walker A motif; other site 760011000811 ATP binding site [chemical binding]; other site 760011000812 Walker B motif; other site 760011000813 arginine finger; other site 760011000814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000815 Walker A motif; other site 760011000816 ATP binding site [chemical binding]; other site 760011000817 Walker B motif; other site 760011000818 arginine finger; other site 760011000819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 760011000820 Protein of unknown function (DUF554); Region: DUF554; pfam04474 760011000821 hypothetical protein; Provisional; Region: PRK08262 760011000822 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760011000823 metal binding site [ion binding]; metal-binding site 760011000824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760011000825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760011000826 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011000827 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011000828 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011000829 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000830 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000831 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000832 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000833 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000834 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000835 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000836 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000837 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000838 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011000839 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011000840 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 760011000841 homodimer interface [polypeptide binding]; other site 760011000842 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 760011000843 active site pocket [active] 760011000844 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760011000845 KilA-N domain; Region: KilA-N; pfam04383 760011000846 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 760011000847 non-specific DNA binding site [nucleotide binding]; other site 760011000848 salt bridge; other site 760011000849 sequence-specific DNA binding site [nucleotide binding]; other site 760011000850 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 760011000851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011000852 S-adenosylmethionine binding site [chemical binding]; other site 760011000853 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 760011000854 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 760011000855 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 760011000856 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 760011000857 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760011000858 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 760011000859 Walker A/P-loop; other site 760011000860 ATP binding site [chemical binding]; other site 760011000861 Q-loop/lid; other site 760011000862 ABC transporter signature motif; other site 760011000863 Walker B; other site 760011000864 D-loop; other site 760011000865 H-loop/switch region; other site 760011000866 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 760011000867 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 760011000868 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 760011000869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760011000870 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 760011000871 dimer interface [polypeptide binding]; other site 760011000872 Cupin domain; Region: Cupin_2; pfam07883 760011000873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011000874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011000875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011000876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011000877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000878 dimer interface [polypeptide binding]; other site 760011000879 conserved gate region; other site 760011000880 putative PBP binding loops; other site 760011000881 ABC-ATPase subunit interface; other site 760011000882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011000883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000884 dimer interface [polypeptide binding]; other site 760011000885 conserved gate region; other site 760011000886 putative PBP binding loops; other site 760011000887 ABC-ATPase subunit interface; other site 760011000888 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760011000889 binding surface 760011000890 TPR repeat; Region: TPR_11; pfam13414 760011000891 TPR motif; other site 760011000892 Phosphotransferase enzyme family; Region: APH; pfam01636 760011000893 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 760011000894 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 760011000895 tetramer interface [polypeptide binding]; other site 760011000896 heme binding pocket [chemical binding]; other site 760011000897 NADPH binding site [chemical binding]; other site 760011000898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011000899 Walker A motif; other site 760011000900 ATP binding site [chemical binding]; other site 760011000901 Walker B motif; other site 760011000902 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 760011000903 aspartate kinase; Reviewed; Region: PRK09034 760011000904 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 760011000905 nucleotide binding site [chemical binding]; other site 760011000906 substrate binding site [chemical binding]; other site 760011000907 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 760011000908 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 760011000909 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 760011000910 Walker A/P-loop; other site 760011000911 ATP binding site [chemical binding]; other site 760011000912 Q-loop/lid; other site 760011000913 ABC transporter signature motif; other site 760011000914 Walker B; other site 760011000915 D-loop; other site 760011000916 H-loop/switch region; other site 760011000917 TOBE domain; Region: TOBE_2; pfam08402 760011000918 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 760011000919 active site 760011000920 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 760011000921 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 760011000922 Potassium binding sites [ion binding]; other site 760011000923 Cesium cation binding sites [ion binding]; other site 760011000924 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 760011000925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011000926 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 760011000927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000928 dimer interface [polypeptide binding]; other site 760011000929 conserved gate region; other site 760011000930 putative PBP binding loops; other site 760011000931 ABC-ATPase subunit interface; other site 760011000932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011000933 dimer interface [polypeptide binding]; other site 760011000934 conserved gate region; other site 760011000935 putative PBP binding loops; other site 760011000936 ABC-ATPase subunit interface; other site 760011000937 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760011000938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011000939 Walker A/P-loop; other site 760011000940 ATP binding site [chemical binding]; other site 760011000941 Q-loop/lid; other site 760011000942 ABC transporter signature motif; other site 760011000943 Walker B; other site 760011000944 D-loop; other site 760011000945 H-loop/switch region; other site 760011000946 TOBE domain; Region: TOBE_2; pfam08402 760011000947 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760011000948 MarR family; Region: MarR_2; pfam12802 760011000949 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 760011000950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760011000951 hydroxyglutarate oxidase; Provisional; Region: PRK11728 760011000952 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760011000953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760011000954 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760011000955 acyl-activating enzyme (AAE) consensus motif; other site 760011000956 acyl-activating enzyme (AAE) consensus motif; other site 760011000957 AMP binding site [chemical binding]; other site 760011000958 active site 760011000959 CoA binding site [chemical binding]; other site 760011000960 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 760011000961 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 760011000962 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 760011000963 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 760011000964 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 760011000965 active site 760011000966 catalytic site [active] 760011000967 substrate binding site [chemical binding]; other site 760011000968 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 760011000969 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 760011000970 active site 760011000971 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 760011000972 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 760011000973 Ligand Binding Site [chemical binding]; other site 760011000974 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 760011000975 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 760011000976 active site 760011000977 trimer interface [polypeptide binding]; other site 760011000978 allosteric site; other site 760011000979 active site lid [active] 760011000980 hexamer (dimer of trimers) interface [polypeptide binding]; other site 760011000981 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 760011000982 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 760011000983 putative active site [active] 760011000984 catalytic site [active] 760011000985 putative metal binding site [ion binding]; other site 760011000986 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 760011000987 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 760011000988 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 760011000989 Domain of unknown function DUF20; Region: UPF0118; pfam01594 760011000990 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760011000991 endonuclease III; Region: ENDO3c; smart00478 760011000992 minor groove reading motif; other site 760011000993 helix-hairpin-helix signature motif; other site 760011000994 substrate binding pocket [chemical binding]; other site 760011000995 active site 760011000996 Protein of unknown function, DUF606; Region: DUF606; pfam04657 760011000997 Protein of unknown function, DUF606; Region: DUF606; pfam04657 760011000998 phosphoserine phosphatase; Provisional; Region: thrH; PRK13582 760011000999 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 760011001000 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 760011001001 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 760011001002 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 760011001003 RNA binding site [nucleotide binding]; other site 760011001004 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 760011001005 YceG-like family; Region: YceG; pfam02618 760011001006 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 760011001007 dimerization interface [polypeptide binding]; other site 760011001008 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 760011001009 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 760011001010 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 760011001011 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 760011001012 active site 760011001013 nucleophile elbow; other site 760011001014 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 760011001015 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 760011001016 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 760011001017 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 760011001018 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 760011001019 putative active site [active] 760011001020 catalytic site [active] 760011001021 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 760011001022 putative active site [active] 760011001023 catalytic site [active] 760011001024 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 760011001025 diiron binding motif [ion binding]; other site 760011001026 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 760011001027 Trp repressor protein; Region: Trp_repressor; cl17266 760011001028 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 760011001029 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 760011001030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 760011001031 helicase 45; Provisional; Region: PTZ00424 760011001032 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 760011001033 ATP binding site [chemical binding]; other site 760011001034 Mg++ binding site [ion binding]; other site 760011001035 motif III; other site 760011001036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011001037 nucleotide binding region [chemical binding]; other site 760011001038 ATP-binding site [chemical binding]; other site 760011001039 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 760011001040 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 760011001041 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 760011001042 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 760011001043 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 760011001044 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 760011001045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001046 dimer interface [polypeptide binding]; other site 760011001047 conserved gate region; other site 760011001048 putative PBP binding loops; other site 760011001049 ABC-ATPase subunit interface; other site 760011001050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001051 dimer interface [polypeptide binding]; other site 760011001052 conserved gate region; other site 760011001053 putative PBP binding loops; other site 760011001054 ABC-ATPase subunit interface; other site 760011001055 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760011001056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011001057 Walker A/P-loop; other site 760011001058 ATP binding site [chemical binding]; other site 760011001059 Q-loop/lid; other site 760011001060 ABC transporter signature motif; other site 760011001061 Walker B; other site 760011001062 D-loop; other site 760011001063 H-loop/switch region; other site 760011001064 TOBE domain; Region: TOBE_2; pfam08402 760011001065 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 760011001066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 760011001067 Fic family protein [Function unknown]; Region: COG3177 760011001068 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760011001069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011001070 Walker A/P-loop; other site 760011001071 ATP binding site [chemical binding]; other site 760011001072 Q-loop/lid; other site 760011001073 ABC transporter signature motif; other site 760011001074 Walker B; other site 760011001075 D-loop; other site 760011001076 H-loop/switch region; other site 760011001077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001078 dimer interface [polypeptide binding]; other site 760011001079 conserved gate region; other site 760011001080 putative PBP binding loops; other site 760011001081 ABC-ATPase subunit interface; other site 760011001082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760011001083 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760011001084 substrate binding pocket [chemical binding]; other site 760011001085 membrane-bound complex binding site; other site 760011001086 hinge residues; other site 760011001087 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 760011001088 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 760011001089 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 760011001090 putative valine binding site [chemical binding]; other site 760011001091 dimer interface [polypeptide binding]; other site 760011001092 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 760011001093 ketol-acid reductoisomerase; Provisional; Region: PRK05479 760011001094 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 760011001095 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 760011001096 2-isopropylmalate synthase; Validated; Region: PRK00915 760011001097 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 760011001098 active site 760011001099 catalytic residues [active] 760011001100 metal binding site [ion binding]; metal-binding site 760011001101 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 760011001102 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 760011001103 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 760011001104 active site 760011001105 catalytic residues [active] 760011001106 metal binding site [ion binding]; metal-binding site 760011001107 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 760011001108 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 760011001109 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 760011001110 substrate binding site [chemical binding]; other site 760011001111 ligand binding site [chemical binding]; other site 760011001112 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 760011001113 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 760011001114 substrate binding site [chemical binding]; other site 760011001115 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 760011001116 tartrate dehydrogenase; Region: TTC; TIGR02089 760011001117 6-phosphogluconate dehydratase; Region: edd; TIGR01196 760011001118 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 760011001119 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 760011001120 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 760011001121 PYR/PP interface [polypeptide binding]; other site 760011001122 dimer interface [polypeptide binding]; other site 760011001123 TPP binding site [chemical binding]; other site 760011001124 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 760011001125 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 760011001126 TPP-binding site [chemical binding]; other site 760011001127 dimer interface [polypeptide binding]; other site 760011001128 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 760011001129 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 760011001130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011001131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011001132 putative substrate translocation pore; other site 760011001133 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 760011001134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011001135 active site 760011001136 motif I; other site 760011001137 motif II; other site 760011001138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011001139 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011001140 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011001141 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011001142 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001143 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 760011001144 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001145 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001146 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001147 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001148 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001149 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001150 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001151 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001152 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001153 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011001154 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011001155 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011001156 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001157 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001158 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001159 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001160 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001161 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001162 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001163 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001164 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001165 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001166 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001167 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011001168 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011001169 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011001170 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001171 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001172 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001173 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760011001175 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 760011001176 putative ligand binding site [chemical binding]; other site 760011001177 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011001178 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011001179 Walker A/P-loop; other site 760011001180 ATP binding site [chemical binding]; other site 760011001181 Q-loop/lid; other site 760011001182 ABC transporter signature motif; other site 760011001183 Walker B; other site 760011001184 D-loop; other site 760011001185 H-loop/switch region; other site 760011001186 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011001187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011001188 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011001189 TM-ABC transporter signature motif; other site 760011001190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011001191 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011001192 TM-ABC transporter signature motif; other site 760011001193 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 760011001194 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 760011001195 putative N- and C-terminal domain interface [polypeptide binding]; other site 760011001196 putative active site [active] 760011001197 MgATP binding site [chemical binding]; other site 760011001198 catalytic site [active] 760011001199 metal binding site [ion binding]; metal-binding site 760011001200 putative carbohydrate binding site [chemical binding]; other site 760011001201 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 760011001202 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 760011001203 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011001204 DNA binding site [nucleotide binding] 760011001205 domain linker motif; other site 760011001206 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760011001207 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011001208 ligand binding site [chemical binding]; other site 760011001209 L-arabinose isomerase; Provisional; Region: PRK02929 760011001210 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 760011001211 hexamer (dimer of trimers) interface [polypeptide binding]; other site 760011001212 trimer interface [polypeptide binding]; other site 760011001213 substrate binding site [chemical binding]; other site 760011001214 Mn binding site [ion binding]; other site 760011001215 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 760011001216 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 760011001217 intersubunit interface [polypeptide binding]; other site 760011001218 active site 760011001219 Zn2+ binding site [ion binding]; other site 760011001220 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 760011001221 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 760011001222 putative catalytic cysteine [active] 760011001223 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 760011001224 putative active site [active] 760011001225 metal binding site [ion binding]; metal-binding site 760011001226 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 760011001227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011001228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760011001229 active site 760011001230 phosphorylation site [posttranslational modification] 760011001231 intermolecular recognition site; other site 760011001232 dimerization interface [polypeptide binding]; other site 760011001233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760011001234 DNA binding site [nucleotide binding] 760011001235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760011001236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011001237 active site 760011001238 phosphorylation site [posttranslational modification] 760011001239 intermolecular recognition site; other site 760011001240 dimerization interface [polypeptide binding]; other site 760011001241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760011001242 DNA binding site [nucleotide binding] 760011001243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760011001244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760011001245 dimer interface [polypeptide binding]; other site 760011001246 phosphorylation site [posttranslational modification] 760011001247 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 760011001248 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 760011001249 domain interfaces; other site 760011001250 active site 760011001251 FMN-binding domain; Region: FMN_bind; cl01081 760011001252 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 760011001253 L-aspartate oxidase; Provisional; Region: PRK06175 760011001254 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 760011001255 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 760011001256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001257 dimer interface [polypeptide binding]; other site 760011001258 conserved gate region; other site 760011001259 putative PBP binding loops; other site 760011001260 ABC-ATPase subunit interface; other site 760011001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011001262 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 760011001263 Walker A/P-loop; other site 760011001264 ATP binding site [chemical binding]; other site 760011001265 Q-loop/lid; other site 760011001266 ABC transporter signature motif; other site 760011001267 Walker B; other site 760011001268 D-loop; other site 760011001269 H-loop/switch region; other site 760011001270 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 760011001271 catalytic loop [active] 760011001272 iron binding site [ion binding]; other site 760011001273 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 760011001274 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 760011001275 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 760011001276 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; smart00902 760011001277 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 760011001278 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 760011001279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760011001280 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760011001281 Protein of unknown function (DUF975); Region: DUF975; cl10504 760011001282 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 760011001283 active site 760011001284 DNA binding site [nucleotide binding] 760011001285 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760011001286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011001287 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 760011001288 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760011001289 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760011001290 Sulfatase; Region: Sulfatase; pfam00884 760011001291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011001292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011001293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001294 dimer interface [polypeptide binding]; other site 760011001295 ABC-ATPase subunit interface; other site 760011001296 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011001297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001298 dimer interface [polypeptide binding]; other site 760011001299 conserved gate region; other site 760011001300 ABC-ATPase subunit interface; other site 760011001301 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 760011001302 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 760011001303 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 760011001304 Sulfatase; Region: Sulfatase; cl17466 760011001305 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760011001306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 760011001307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011001308 H+ Antiporter protein; Region: 2A0121; TIGR00900 760011001309 putative substrate translocation pore; other site 760011001310 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760011001311 metal-binding site [ion binding] 760011001312 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 760011001313 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760011001314 metal-binding site [ion binding] 760011001315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760011001316 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760011001317 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 760011001318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760011001319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760011001320 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 760011001321 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760011001322 active site 760011001323 metal binding site [ion binding]; metal-binding site 760011001324 homotetramer interface [polypeptide binding]; other site 760011001325 glutamate dehydrogenase; Provisional; Region: PRK09414 760011001326 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 760011001327 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 760011001328 NAD(P) binding site [chemical binding]; other site 760011001329 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 760011001330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011001331 putative substrate translocation pore; other site 760011001332 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 760011001333 FAD binding domain; Region: FAD_binding_4; pfam01565 760011001334 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 760011001335 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 760011001336 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760011001337 active site 760011001338 HIGH motif; other site 760011001339 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 760011001340 KMSKS motif; other site 760011001341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760011001342 tRNA binding surface [nucleotide binding]; other site 760011001343 anticodon binding site; other site 760011001344 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 760011001345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760011001346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760011001347 DNA binding residues [nucleotide binding] 760011001348 Putative zinc-finger; Region: zf-HC2; pfam13490 760011001349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011001350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001351 dimer interface [polypeptide binding]; other site 760011001352 conserved gate region; other site 760011001353 putative PBP binding loops; other site 760011001354 ABC-ATPase subunit interface; other site 760011001355 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011001356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001357 dimer interface [polypeptide binding]; other site 760011001358 conserved gate region; other site 760011001359 ABC-ATPase subunit interface; other site 760011001360 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 760011001361 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011001362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011001363 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 760011001364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011001365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011001366 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 760011001367 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760011001368 HIGH motif; other site 760011001369 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760011001370 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760011001371 active site 760011001372 KMSKS motif; other site 760011001373 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 760011001374 tRNA binding surface [nucleotide binding]; other site 760011001375 anticodon binding site; other site 760011001376 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 760011001377 Peptidase family U32; Region: Peptidase_U32; pfam01136 760011001378 ATP-dependent protease La; Region: lon; TIGR00763 760011001379 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011001380 Walker A motif; other site 760011001381 ATP binding site [chemical binding]; other site 760011001382 Walker B motif; other site 760011001383 arginine finger; other site 760011001384 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 760011001385 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 760011001386 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 760011001387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 760011001388 dimerization interface [polypeptide binding]; other site 760011001389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760011001390 dimer interface [polypeptide binding]; other site 760011001391 phosphorylation site [posttranslational modification] 760011001392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011001393 ATP binding site [chemical binding]; other site 760011001394 Mg2+ binding site [ion binding]; other site 760011001395 G-X-G motif; other site 760011001396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760011001397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011001398 active site 760011001399 phosphorylation site [posttranslational modification] 760011001400 intermolecular recognition site; other site 760011001401 dimerization interface [polypeptide binding]; other site 760011001402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760011001403 DNA binding site [nucleotide binding] 760011001404 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 760011001405 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 760011001406 Recombination protein O N terminal; Region: RecO_N; pfam11967 760011001407 Recombination protein O C terminal; Region: RecO_C; pfam02565 760011001408 DHH family; Region: DHH; pfam01368 760011001409 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 760011001410 DHHA1 domain; Region: DHHA1; pfam02272 760011001411 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 760011001412 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 760011001413 Protein of unknown function DUF111; Region: DUF111; cl03398 760011001414 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 760011001415 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 760011001416 NAD binding site [chemical binding]; other site 760011001417 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 760011001418 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011001419 catalytic residue [active] 760011001420 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 760011001421 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 760011001422 putative DNA binding site [nucleotide binding]; other site 760011001423 putative Zn2+ binding site [ion binding]; other site 760011001424 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 760011001425 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 760011001426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011001427 ATP binding site [chemical binding]; other site 760011001428 Mg2+ binding site [ion binding]; other site 760011001429 G-X-G motif; other site 760011001430 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 760011001431 ATP binding site [chemical binding]; other site 760011001432 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 760011001433 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 760011001434 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 760011001435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011001436 Zn2+ binding site [ion binding]; other site 760011001437 Mg2+ binding site [ion binding]; other site 760011001438 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760011001439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011001440 FeS/SAM binding site; other site 760011001441 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 760011001442 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011001443 FeS/SAM binding site; other site 760011001444 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 760011001445 Methyltransferase domain; Region: Methyltransf_31; pfam13847 760011001446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011001447 S-adenosylmethionine binding site [chemical binding]; other site 760011001448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011001449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011001450 putative substrate translocation pore; other site 760011001451 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011001452 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 760011001453 FeS/SAM binding site; other site 760011001454 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 760011001455 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011001456 active site 760011001457 HIGH motif; other site 760011001458 nucleotide binding site [chemical binding]; other site 760011001459 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760011001460 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760011001461 active site 760011001462 KMSKS motif; other site 760011001463 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 760011001464 tRNA binding surface [nucleotide binding]; other site 760011001465 anticodon binding site; other site 760011001466 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 760011001467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760011001468 dimerization interface [polypeptide binding]; other site 760011001469 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 760011001470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 760011001471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760011001472 dimer interface [polypeptide binding]; other site 760011001473 phosphorylation site [posttranslational modification] 760011001474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011001475 ATP binding site [chemical binding]; other site 760011001476 Mg2+ binding site [ion binding]; other site 760011001477 G-X-G motif; other site 760011001478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 760011001479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011001480 active site 760011001481 phosphorylation site [posttranslational modification] 760011001482 intermolecular recognition site; other site 760011001483 dimerization interface [polypeptide binding]; other site 760011001484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 760011001485 DNA binding site [nucleotide binding] 760011001486 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760011001487 catalytic core [active] 760011001488 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760011001489 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760011001490 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760011001491 ligand binding site [chemical binding]; other site 760011001492 flexible hinge region; other site 760011001493 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 760011001494 putative switch regulator; other site 760011001495 non-specific DNA interactions [nucleotide binding]; other site 760011001496 DNA binding site [nucleotide binding] 760011001497 sequence specific DNA binding site [nucleotide binding]; other site 760011001498 putative cAMP binding site [chemical binding]; other site 760011001499 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 760011001500 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 760011001501 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 760011001502 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 760011001503 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 760011001504 dimer interface [polypeptide binding]; other site 760011001505 putative threonine allosteric regulatory site; other site 760011001506 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 760011001507 putative threonine allosteric regulatory site; other site 760011001508 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 760011001509 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 760011001510 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 760011001511 threonine synthase; Validated; Region: PRK09225 760011001512 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 760011001513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011001514 catalytic residue [active] 760011001515 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 760011001516 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 760011001517 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 760011001518 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 760011001519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011001520 ATP binding site [chemical binding]; other site 760011001521 putative Mg++ binding site [ion binding]; other site 760011001522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011001523 nucleotide binding region [chemical binding]; other site 760011001524 ATP-binding site [chemical binding]; other site 760011001525 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760011001526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 760011001527 putative acyl-acceptor binding pocket; other site 760011001528 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011001529 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011001530 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011001531 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001532 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001533 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001534 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001535 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011001536 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 760011001537 PBP superfamily domain; Region: PBP_like_2; cl17296 760011001538 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 760011001539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001540 dimer interface [polypeptide binding]; other site 760011001541 conserved gate region; other site 760011001542 putative PBP binding loops; other site 760011001543 ABC-ATPase subunit interface; other site 760011001544 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 760011001545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001546 dimer interface [polypeptide binding]; other site 760011001547 conserved gate region; other site 760011001548 putative PBP binding loops; other site 760011001549 ABC-ATPase subunit interface; other site 760011001550 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 760011001551 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 760011001552 Walker A/P-loop; other site 760011001553 ATP binding site [chemical binding]; other site 760011001554 Q-loop/lid; other site 760011001555 ABC transporter signature motif; other site 760011001556 Walker B; other site 760011001557 D-loop; other site 760011001558 H-loop/switch region; other site 760011001559 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 760011001560 PhoU domain; Region: PhoU; pfam01895 760011001561 PhoU domain; Region: PhoU; pfam01895 760011001562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011001563 S-adenosylmethionine binding site [chemical binding]; other site 760011001564 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 760011001565 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 760011001566 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011001567 catalytic residue [active] 760011001568 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011001569 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011001570 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011001571 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001572 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001573 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001574 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001575 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001576 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001577 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001578 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001579 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001580 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001581 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011001582 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011001583 4-alpha-glucanotransferase; Provisional; Region: PRK14508 760011001584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011001585 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011001586 DNA binding site [nucleotide binding] 760011001587 domain linker motif; other site 760011001588 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011001589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011001590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001591 dimer interface [polypeptide binding]; other site 760011001592 conserved gate region; other site 760011001593 putative PBP binding loops; other site 760011001594 ABC-ATPase subunit interface; other site 760011001595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001596 dimer interface [polypeptide binding]; other site 760011001597 conserved gate region; other site 760011001598 putative PBP binding loops; other site 760011001599 ABC-ATPase subunit interface; other site 760011001600 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 760011001601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011001602 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 760011001603 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760011001604 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 760011001605 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 760011001606 active site 760011001607 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 760011001608 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760011001609 catalytic residue [active] 760011001610 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760011001611 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760011001612 active site 760011001613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760011001614 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760011001615 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 760011001616 GTPase RsgA; Reviewed; Region: PRK00098 760011001617 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 760011001618 RNA binding site [nucleotide binding]; other site 760011001619 homodimer interface [polypeptide binding]; other site 760011001620 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 760011001621 GTPase/Zn-binding domain interface [polypeptide binding]; other site 760011001622 GTP/Mg2+ binding site [chemical binding]; other site 760011001623 G4 box; other site 760011001624 G5 box; other site 760011001625 G1 box; other site 760011001626 Switch I region; other site 760011001627 G2 box; other site 760011001628 G3 box; other site 760011001629 Switch II region; other site 760011001630 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 760011001631 MutS domain III; Region: MutS_III; pfam05192 760011001632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011001633 Walker A/P-loop; other site 760011001634 ATP binding site [chemical binding]; other site 760011001635 Q-loop/lid; other site 760011001636 ABC transporter signature motif; other site 760011001637 Walker B; other site 760011001638 D-loop; other site 760011001639 H-loop/switch region; other site 760011001640 Smr domain; Region: Smr; pfam01713 760011001641 Protein of unknown function (DUF969); Region: DUF969; pfam06149 760011001642 Predicted membrane protein [Function unknown]; Region: COG3817 760011001643 Protein of unknown function (DUF979); Region: DUF979; pfam06166 760011001644 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 760011001645 putative substrate binding pocket [chemical binding]; other site 760011001646 AC domain interface; other site 760011001647 catalytic triad [active] 760011001648 AB domain interface; other site 760011001649 interchain disulfide; other site 760011001650 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 760011001651 putative active site pocket [active] 760011001652 dimerization interface [polypeptide binding]; other site 760011001653 putative catalytic residue [active] 760011001654 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 760011001655 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 760011001656 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 760011001657 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011001658 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 760011001659 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 760011001660 GcpE protein; Region: GcpE; pfam04551 760011001661 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 760011001662 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 760011001663 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760011001664 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 760011001665 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 760011001666 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 760011001667 PhoH-like protein; Region: PhoH; pfam02562 760011001668 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 760011001669 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 760011001670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011001671 Zn2+ binding site [ion binding]; other site 760011001672 Mg2+ binding site [ion binding]; other site 760011001673 metal-binding heat shock protein; Provisional; Region: PRK00016 760011001674 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 760011001675 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 760011001676 Transporter associated domain; Region: CorC_HlyC; smart01091 760011001677 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 760011001678 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 760011001679 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 760011001680 Phosphoglycerate kinase; Region: PGK; pfam00162 760011001681 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 760011001682 substrate binding site [chemical binding]; other site 760011001683 hinge regions; other site 760011001684 ADP binding site [chemical binding]; other site 760011001685 catalytic site [active] 760011001686 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 760011001687 triosephosphate isomerase; Provisional; Region: PRK14565 760011001688 substrate binding site [chemical binding]; other site 760011001689 dimer interface [polypeptide binding]; other site 760011001690 catalytic triad [active] 760011001691 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011001692 SurA N-terminal domain; Region: SurA_N; pfam09312 760011001693 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760011001694 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 760011001695 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 760011001696 active site 760011001697 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 760011001698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011001699 active site 760011001700 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 760011001701 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 760011001702 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 760011001703 homodimer interface [polypeptide binding]; other site 760011001704 NADP binding site [chemical binding]; other site 760011001705 substrate binding site [chemical binding]; other site 760011001706 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335 760011001707 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760011001708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011001709 FeS/SAM binding site; other site 760011001710 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 760011001711 classical (c) SDRs; Region: SDR_c; cd05233 760011001712 NAD(P) binding site [chemical binding]; other site 760011001713 active site 760011001714 NAD-dependent deacetylase; Provisional; Region: PRK00481 760011001715 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 760011001716 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 760011001717 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 760011001718 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 760011001719 putative metal binding site [ion binding]; other site 760011001720 Nucleopolyhedrovirus protein of unknown function (DUF912); Region: DUF912; pfam06024 760011001721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011001722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011001723 DNA binding site [nucleotide binding] 760011001724 domain linker motif; other site 760011001725 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 760011001726 ligand binding site [chemical binding]; other site 760011001727 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011001728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001729 dimer interface [polypeptide binding]; other site 760011001730 conserved gate region; other site 760011001731 putative PBP binding loops; other site 760011001732 ABC-ATPase subunit interface; other site 760011001733 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011001734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011001735 dimer interface [polypeptide binding]; other site 760011001736 conserved gate region; other site 760011001737 ABC-ATPase subunit interface; other site 760011001738 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 760011001739 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 760011001740 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 760011001741 hypothetical protein; Provisional; Region: PRK08392 760011001742 active site 760011001743 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 760011001744 sucrose phosphorylase; Provisional; Region: PRK13840 760011001745 active site 760011001746 homodimer interface [polypeptide binding]; other site 760011001747 catalytic site [active] 760011001748 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 760011001749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760011001750 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011001751 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 760011001752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011001753 DNA-binding site [nucleotide binding]; DNA binding site 760011001754 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 760011001755 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 760011001756 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 760011001757 THF binding site; other site 760011001758 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 760011001759 substrate binding site [chemical binding]; other site 760011001760 THF binding site; other site 760011001761 zinc-binding site [ion binding]; other site 760011001762 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 760011001763 FAD binding site [chemical binding]; other site 760011001764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760011001765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760011001766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760011001767 dimerization interface [polypeptide binding]; other site 760011001768 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 760011001769 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 760011001770 RNA/DNA hybrid binding site [nucleotide binding]; other site 760011001771 active site 760011001772 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 760011001773 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760011001774 Walker A/P-loop; other site 760011001775 ATP binding site [chemical binding]; other site 760011001776 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 760011001777 Q-loop/lid; other site 760011001778 ABC transporter signature motif; other site 760011001779 Walker B; other site 760011001780 D-loop; other site 760011001781 H-loop/switch region; other site 760011001782 signal recognition particle protein; Provisional; Region: PRK10867 760011001783 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 760011001784 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 760011001785 P loop; other site 760011001786 GTP binding site [chemical binding]; other site 760011001787 Signal peptide binding domain; Region: SRP_SPB; pfam02978 760011001788 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 760011001789 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 760011001790 hypothetical protein; Provisional; Region: PRK00468 760011001791 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 760011001792 RimM N-terminal domain; Region: RimM; pfam01782 760011001793 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 760011001794 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 760011001795 hypothetical protein; Reviewed; Region: PRK12497 760011001796 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 760011001797 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 760011001798 active site 760011001799 (T/H)XGH motif; other site 760011001800 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 760011001801 acyl carrier protein; Provisional; Region: acpP; PRK00982 760011001802 ribonuclease III; Reviewed; Region: rnc; PRK00102 760011001803 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 760011001804 dimerization interface [polypeptide binding]; other site 760011001805 active site 760011001806 metal binding site [ion binding]; metal-binding site 760011001807 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 760011001808 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 760011001809 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 760011001810 active site 760011001811 NTP binding site [chemical binding]; other site 760011001812 metal binding triad [ion binding]; metal-binding site 760011001813 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 760011001814 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011001815 Zn2+ binding site [ion binding]; other site 760011001816 Mg2+ binding site [ion binding]; other site 760011001817 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 760011001818 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 760011001819 HIGH motif; other site 760011001820 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 760011001821 active site 760011001822 KMSKS motif; other site 760011001823 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 760011001824 tRNA binding surface [nucleotide binding]; other site 760011001825 anticodon binding site; other site 760011001826 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 760011001827 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 760011001828 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 760011001829 Ligand Binding Site [chemical binding]; other site 760011001830 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 760011001831 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 760011001832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011001833 catalytic residue [active] 760011001834 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 760011001835 dimer interface [polypeptide binding]; other site 760011001836 active site 760011001837 metal binding site [ion binding]; metal-binding site 760011001838 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760011001839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011001840 ATP binding site [chemical binding]; other site 760011001841 putative Mg++ binding site [ion binding]; other site 760011001842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011001843 nucleotide binding region [chemical binding]; other site 760011001844 ATP-binding site [chemical binding]; other site 760011001845 Helicase associated domain (HA2); Region: HA2; pfam04408 760011001846 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 760011001847 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 760011001848 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 760011001849 dimer interface [polypeptide binding]; other site 760011001850 motif 1; other site 760011001851 active site 760011001852 motif 2; other site 760011001853 motif 3; other site 760011001854 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 760011001855 anticodon binding site; other site 760011001856 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 760011001857 active site 760011001858 NTP binding site [chemical binding]; other site 760011001859 metal binding triad [ion binding]; metal-binding site 760011001860 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 760011001861 AAA domain; Region: AAA_17; pfam13207 760011001862 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 760011001863 SLBB domain; Region: SLBB; pfam10531 760011001864 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760011001865 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 760011001866 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 760011001867 FMN-binding domain; Region: FMN_bind; pfam04205 760011001868 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 760011001869 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 760011001870 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 760011001871 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 760011001872 peptide chain release factor 2; Validated; Region: prfB; PRK00578 760011001873 PCRF domain; Region: PCRF; pfam03462 760011001874 RF-1 domain; Region: RF-1; pfam00472 760011001875 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 760011001876 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 760011001877 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760011001878 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 760011001879 FtsX-like permease family; Region: FtsX; pfam02687 760011001880 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760011001881 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760011001882 Walker A/P-loop; other site 760011001883 ATP binding site [chemical binding]; other site 760011001884 Q-loop/lid; other site 760011001885 ABC transporter signature motif; other site 760011001886 Walker B; other site 760011001887 D-loop; other site 760011001888 H-loop/switch region; other site 760011001889 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 760011001890 FtsX-like permease family; Region: FtsX; pfam02687 760011001891 ribonuclease Z; Region: RNase_Z; TIGR02651 760011001892 Septum formation initiator; Region: DivIC; cl17659 760011001893 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 760011001894 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 760011001895 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 760011001896 Thiamine pyrophosphokinase; Region: TPK; cd07995 760011001897 active site 760011001898 dimerization interface [polypeptide binding]; other site 760011001899 thiamine binding site [chemical binding]; other site 760011001900 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037 760011001901 homotrimer interaction site [polypeptide binding]; other site 760011001902 active site 760011001903 Helix-turn-helix domain; Region: HTH_17; pfam12728 760011001904 DNA adenine methylase (dam); Region: dam; TIGR00571 760011001905 DpnII restriction endonuclease; Region: DpnII; pfam04556 760011001906 DNA methylase; Region: N6_N4_Mtase; cl17433 760011001907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011001908 S-adenosylmethionine binding site [chemical binding]; other site 760011001909 DNA methylase; Region: N6_N4_Mtase; cl17433 760011001910 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 760011001911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760011001912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760011001913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760011001914 dimerization interface [polypeptide binding]; other site 760011001915 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011001916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760011001917 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760011001918 active site 760011001919 catalytic tetrad [active] 760011001920 Uncharacterized conserved protein [Function unknown]; Region: COG4925 760011001921 maltose O-acetyltransferase; Provisional; Region: PRK10092 760011001922 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 760011001923 active site 760011001924 substrate binding site [chemical binding]; other site 760011001925 trimer interface [polypeptide binding]; other site 760011001926 CoA binding site [chemical binding]; other site 760011001927 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760011001928 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 760011001929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760011001930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760011001931 FMN-binding domain; Region: FMN_bind; cl01081 760011001932 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 760011001933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 760011001934 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760011001935 Walker A/P-loop; other site 760011001936 ATP binding site [chemical binding]; other site 760011001937 Q-loop/lid; other site 760011001938 ABC transporter signature motif; other site 760011001939 Walker B; other site 760011001940 D-loop; other site 760011001941 H-loop/switch region; other site 760011001942 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 760011001943 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 760011001944 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 760011001945 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 760011001946 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 760011001947 FMN binding site [chemical binding]; other site 760011001948 dimer interface [polypeptide binding]; other site 760011001949 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 760011001950 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760011001951 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 760011001952 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 760011001953 active site 760011001954 dimer interface [polypeptide binding]; other site 760011001955 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 760011001956 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 760011001957 active site 760011001958 FMN binding site [chemical binding]; other site 760011001959 substrate binding site [chemical binding]; other site 760011001960 3Fe-4S cluster binding site [ion binding]; other site 760011001961 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 760011001962 domain interface; other site 760011001963 Predicted transcriptional regulator [Transcription]; Region: COG1959 760011001964 Transcriptional regulator; Region: Rrf2; pfam02082 760011001965 Predicted transcriptional regulator [Transcription]; Region: COG1959 760011001966 Transcriptional regulator; Region: Rrf2; cl17282 760011001967 short chain dehydrogenase; Provisional; Region: PRK06179 760011001968 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 760011001969 NADP binding site [chemical binding]; other site 760011001970 active site 760011001971 steroid binding site; other site 760011001972 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 760011001973 active site 760011001974 catalytic residues [active] 760011001975 DNA binding site [nucleotide binding] 760011001976 Int/Topo IB signature motif; other site 760011001977 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 760011001978 SmpB-tmRNA interface; other site 760011001979 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 760011001980 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 760011001981 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760011001982 Catalytic site [active] 760011001983 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 760011001984 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 760011001985 HemN C-terminal domain; Region: HemN_C; pfam06969 760011001986 hypothetical protein; Validated; Region: PRK00110 760011001987 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 760011001988 active site 760011001989 putative DNA-binding cleft [nucleotide binding]; other site 760011001990 dimer interface [polypeptide binding]; other site 760011001991 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 760011001992 RuvA N terminal domain; Region: RuvA_N; pfam01330 760011001993 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 760011001994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011001995 Walker A motif; other site 760011001996 ATP binding site [chemical binding]; other site 760011001997 Walker B motif; other site 760011001998 arginine finger; other site 760011001999 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 760011002000 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 760011002001 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 760011002002 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 760011002003 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 760011002004 TMP-binding site; other site 760011002005 ATP-binding site [chemical binding]; other site 760011002006 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 760011002007 Family of unknown function (DUF490); Region: DUF490; pfam04357 760011002008 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 760011002009 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760011002010 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760011002011 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760011002012 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 760011002013 Surface antigen; Region: Bac_surface_Ag; pfam01103 760011002014 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 760011002015 MutS domain I; Region: MutS_I; pfam01624 760011002016 MutS domain II; Region: MutS_II; pfam05188 760011002017 MutS domain III; Region: MutS_III; pfam05192 760011002018 MutS domain V; Region: MutS_V; pfam00488 760011002019 Walker A/P-loop; other site 760011002020 ATP binding site [chemical binding]; other site 760011002021 Q-loop/lid; other site 760011002022 ABC transporter signature motif; other site 760011002023 Walker B; other site 760011002024 D-loop; other site 760011002025 H-loop/switch region; other site 760011002026 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 760011002027 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011002028 active site 760011002029 Sm and related proteins; Region: Sm_like; cl00259 760011002030 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 760011002031 heptamer interface [polypeptide binding]; other site 760011002032 Sm1 motif; other site 760011002033 hexamer interface [polypeptide binding]; other site 760011002034 RNA binding site [nucleotide binding]; other site 760011002035 Sm2 motif; other site 760011002036 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 760011002037 NusA N-terminal domain; Region: NusA_N; pfam08529 760011002038 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 760011002039 RNA binding site [nucleotide binding]; other site 760011002040 homodimer interface [polypeptide binding]; other site 760011002041 NusA-like KH domain; Region: KH_5; pfam13184 760011002042 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 760011002043 G-X-X-G motif; other site 760011002044 translation initiation factor IF-2; Region: IF-2; TIGR00487 760011002045 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 760011002046 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 760011002047 G1 box; other site 760011002048 putative GEF interaction site [polypeptide binding]; other site 760011002049 GTP/Mg2+ binding site [chemical binding]; other site 760011002050 Switch I region; other site 760011002051 G2 box; other site 760011002052 G3 box; other site 760011002053 Switch II region; other site 760011002054 G4 box; other site 760011002055 G5 box; other site 760011002056 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 760011002057 Translation-initiation factor 2; Region: IF-2; pfam11987 760011002058 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 760011002059 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 760011002060 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 760011002061 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 760011002062 RNA binding site [nucleotide binding]; other site 760011002063 active site 760011002064 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 760011002065 active site 760011002066 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 760011002067 16S/18S rRNA binding site [nucleotide binding]; other site 760011002068 S13e-L30e interaction site [polypeptide binding]; other site 760011002069 25S rRNA binding site [nucleotide binding]; other site 760011002070 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 760011002071 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 760011002072 RNase E interface [polypeptide binding]; other site 760011002073 trimer interface [polypeptide binding]; other site 760011002074 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 760011002075 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 760011002076 RNase E interface [polypeptide binding]; other site 760011002077 trimer interface [polypeptide binding]; other site 760011002078 active site 760011002079 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 760011002080 putative nucleic acid binding region [nucleotide binding]; other site 760011002081 G-X-X-G motif; other site 760011002082 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 760011002083 RNA binding site [nucleotide binding]; other site 760011002084 domain interface; other site 760011002085 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 760011002086 trimer interface [polypeptide binding]; other site 760011002087 active site 760011002088 Predicted permeases [General function prediction only]; Region: COG0795 760011002089 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760011002090 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760011002091 Predicted permeases [General function prediction only]; Region: COG0795 760011002092 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 760011002093 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 760011002094 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 760011002095 integral membrane protein MviN; Region: mviN; TIGR01695 760011002096 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 760011002097 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 760011002098 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 760011002099 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 760011002100 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 760011002101 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 760011002102 substrate binding site [chemical binding]; other site 760011002103 hexamer interface [polypeptide binding]; other site 760011002104 metal binding site [ion binding]; metal-binding site 760011002105 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 760011002106 putative active site [active] 760011002107 dimerization interface [polypeptide binding]; other site 760011002108 putative tRNAtyr binding site [nucleotide binding]; other site 760011002109 recombinase A; Provisional; Region: recA; PRK09354 760011002110 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 760011002111 hexamer interface [polypeptide binding]; other site 760011002112 Walker A motif; other site 760011002113 ATP binding site [chemical binding]; other site 760011002114 Walker B motif; other site 760011002115 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 760011002116 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 760011002117 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 760011002118 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760011002119 RNA binding surface [nucleotide binding]; other site 760011002120 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 760011002121 active site 760011002122 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 760011002123 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 760011002124 CMP-binding site; other site 760011002125 The sites determining sugar specificity; other site 760011002126 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 760011002127 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 760011002128 RNA binding site [nucleotide binding]; other site 760011002129 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 760011002130 RNA binding site [nucleotide binding]; other site 760011002131 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 760011002132 RNA binding site [nucleotide binding]; other site 760011002133 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 760011002134 RNA binding site [nucleotide binding]; other site 760011002135 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 760011002136 RNA binding site [nucleotide binding]; other site 760011002137 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 760011002138 RNA binding site [nucleotide binding]; other site 760011002139 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 760011002140 Tetratricopeptide repeat; Region: TPR_6; pfam13174 760011002141 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 760011002142 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 760011002143 homodimer interface [polypeptide binding]; other site 760011002144 metal binding site [ion binding]; metal-binding site 760011002145 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 760011002146 homodimer interface [polypeptide binding]; other site 760011002147 active site 760011002148 putative chemical substrate binding site [chemical binding]; other site 760011002149 metal binding site [ion binding]; metal-binding site 760011002150 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 760011002151 Putative zinc ribbon domain; Region: DUF164; pfam02591 760011002152 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 760011002153 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 760011002154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760011002155 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 760011002156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760011002157 DNA binding residues [nucleotide binding] 760011002158 DNA primase; Validated; Region: dnaG; PRK05667 760011002159 CHC2 zinc finger; Region: zf-CHC2; pfam01807 760011002160 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 760011002161 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 760011002162 active site 760011002163 metal binding site [ion binding]; metal-binding site 760011002164 interdomain interaction site; other site 760011002165 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 760011002166 Flagellin N-methylase; Region: FliB; cl00497 760011002167 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 760011002168 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760011002169 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760011002170 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760011002171 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 760011002172 Type III pantothenate kinase; Region: Pan_kinase; cl17198 760011002173 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 760011002174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760011002175 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760011002176 ABC transporter; Region: ABC_tran_2; pfam12848 760011002177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760011002178 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011002179 active site 760011002180 UGMP family protein; Validated; Region: PRK09604 760011002181 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 760011002182 pyruvate phosphate dikinase; Provisional; Region: PRK09279 760011002183 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 760011002184 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760011002185 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760011002186 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 760011002187 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 760011002188 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 760011002189 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 760011002190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 760011002191 DNA binding residues [nucleotide binding] 760011002192 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 760011002193 oligomerisation interface [polypeptide binding]; other site 760011002194 mobile loop; other site 760011002195 roof hairpin; other site 760011002196 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 760011002197 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 760011002198 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760011002199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011002200 active site 760011002201 phosphorylation site [posttranslational modification] 760011002202 intermolecular recognition site; other site 760011002203 dimerization interface [polypeptide binding]; other site 760011002204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011002205 Walker A motif; other site 760011002206 ATP binding site [chemical binding]; other site 760011002207 Walker B motif; other site 760011002208 arginine finger; other site 760011002209 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760011002210 sensory histidine kinase AtoS; Provisional; Region: PRK11360 760011002211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760011002212 dimer interface [polypeptide binding]; other site 760011002213 phosphorylation site [posttranslational modification] 760011002214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011002215 ATP binding site [chemical binding]; other site 760011002216 Mg2+ binding site [ion binding]; other site 760011002217 G-X-G motif; other site 760011002218 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 760011002219 DNA polymerase III subunit delta'; Validated; Region: PRK08485 760011002220 Colicin V production protein; Region: Colicin_V; pfam02674 760011002221 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 760011002222 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 760011002223 active site 760011002224 homodimer interface [polypeptide binding]; other site 760011002225 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 760011002226 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 760011002227 SEC-C motif; Region: SEC-C; pfam02810 760011002228 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 760011002229 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760011002230 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 760011002231 Peptidase family M23; Region: Peptidase_M23; pfam01551 760011002232 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 760011002233 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 760011002234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 760011002235 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 760011002236 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760011002237 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 760011002238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011002239 Walker A motif; other site 760011002240 ATP binding site [chemical binding]; other site 760011002241 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 760011002242 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 760011002243 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 760011002244 active site 760011002245 HslU subunit interaction site [polypeptide binding]; other site 760011002246 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760011002247 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 760011002248 active site 760011002249 DNA binding site [nucleotide binding] 760011002250 Int/Topo IB signature motif; other site 760011002251 DNA protecting protein DprA; Region: dprA; TIGR00732 760011002252 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 760011002253 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 760011002254 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760011002255 active site 760011002256 DNA binding site [nucleotide binding] 760011002257 Int/Topo IB signature motif; other site 760011002258 cell division protein FtsZ; Validated; Region: PRK09330 760011002259 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 760011002260 nucleotide binding site [chemical binding]; other site 760011002261 SulA interaction site; other site 760011002262 cell division protein FtsA; Region: ftsA; TIGR01174 760011002263 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760011002264 nucleotide binding site [chemical binding]; other site 760011002265 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 760011002266 Cell division protein FtsA; Region: FtsA; pfam14450 760011002267 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 760011002268 cell division protein FtsW; Region: ftsW; TIGR02614 760011002269 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 760011002270 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 760011002271 Mg++ binding site [ion binding]; other site 760011002272 putative catalytic motif [active] 760011002273 putative substrate binding site [chemical binding]; other site 760011002274 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760011002275 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 760011002276 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760011002277 Cell division protein FtsL; Region: FtsL; cl11433 760011002278 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 760011002279 MraW methylase family; Region: Methyltransf_5; cl17771 760011002280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 760011002281 MraZ protein; Region: MraZ; pfam02381 760011002282 MraZ protein; Region: MraZ; pfam02381 760011002283 Uncharacterized conserved protein [Function unknown]; Region: COG1543 760011002284 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 760011002285 active site 760011002286 substrate binding site [chemical binding]; other site 760011002287 catalytic site [active] 760011002288 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 760011002289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 760011002290 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 760011002291 active site 760011002292 catalytic site [active] 760011002293 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 760011002294 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 760011002295 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760011002296 Walker A/P-loop; other site 760011002297 ATP binding site [chemical binding]; other site 760011002298 Q-loop/lid; other site 760011002299 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 760011002300 ABC transporter signature motif; other site 760011002301 Walker B; other site 760011002302 D-loop; other site 760011002303 H-loop/switch region; other site 760011002304 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 760011002305 ATP-NAD kinase; Region: NAD_kinase; pfam01513 760011002306 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 760011002307 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760011002308 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011002309 catalytic residue [active] 760011002310 peroxiredoxin; Region: AhpC; TIGR03137 760011002311 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 760011002312 dimer interface [polypeptide binding]; other site 760011002313 decamer (pentamer of dimers) interface [polypeptide binding]; other site 760011002314 catalytic triad [active] 760011002315 peroxidatic and resolving cysteines [active] 760011002316 Mg chelatase-related protein; Region: TIGR00368 760011002317 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 760011002318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011002319 Walker A motif; other site 760011002320 ATP binding site [chemical binding]; other site 760011002321 Walker B motif; other site 760011002322 arginine finger; other site 760011002323 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 760011002324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002325 dimer interface [polypeptide binding]; other site 760011002326 conserved gate region; other site 760011002327 putative PBP binding loops; other site 760011002328 ABC-ATPase subunit interface; other site 760011002329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002331 dimer interface [polypeptide binding]; other site 760011002332 conserved gate region; other site 760011002333 ABC-ATPase subunit interface; other site 760011002334 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011002335 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011002336 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 760011002337 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 760011002338 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 760011002339 inhibitor binding site; inhibition site 760011002340 active site 760011002341 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 760011002342 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 760011002343 metal-binding site [ion binding] 760011002344 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760011002345 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760011002346 elongation factor G; Reviewed; Region: PRK12739 760011002347 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 760011002348 G1 box; other site 760011002349 putative GEF interaction site [polypeptide binding]; other site 760011002350 GTP/Mg2+ binding site [chemical binding]; other site 760011002351 Switch I region; other site 760011002352 G2 box; other site 760011002353 G3 box; other site 760011002354 Switch II region; other site 760011002355 G4 box; other site 760011002356 G5 box; other site 760011002357 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 760011002358 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 760011002359 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 760011002360 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 760011002361 elongation factor G; Reviewed; Region: PRK12740 760011002362 G1 box; other site 760011002363 putative GEF interaction site [polypeptide binding]; other site 760011002364 GTP/Mg2+ binding site [chemical binding]; other site 760011002365 Switch I region; other site 760011002366 G2 box; other site 760011002367 G3 box; other site 760011002368 Switch II region; other site 760011002369 G4 box; other site 760011002370 G5 box; other site 760011002371 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 760011002372 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 760011002373 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 760011002374 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 760011002375 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 760011002376 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 760011002377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011002378 ATP binding site [chemical binding]; other site 760011002379 putative Mg++ binding site [ion binding]; other site 760011002380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011002381 nucleotide binding region [chemical binding]; other site 760011002382 ATP-binding site [chemical binding]; other site 760011002383 TRCF domain; Region: TRCF; pfam03461 760011002384 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 760011002385 active site 760011002386 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 760011002387 Family description; Region: ACT_7; pfam13840 760011002388 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 760011002389 ATP cone domain; Region: ATP-cone; pfam03477 760011002390 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 760011002391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011002392 Zn2+ binding site [ion binding]; other site 760011002393 Mg2+ binding site [ion binding]; other site 760011002394 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 760011002395 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 760011002396 active site 760011002397 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 760011002398 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 760011002399 Tetramer interface [polypeptide binding]; other site 760011002400 active site 760011002401 FMN-binding site [chemical binding]; other site 760011002402 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 760011002403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760011002404 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760011002405 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760011002406 ATP binding site [chemical binding]; other site 760011002407 putative Mg++ binding site [ion binding]; other site 760011002408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011002409 nucleotide binding region [chemical binding]; other site 760011002410 ATP-binding site [chemical binding]; other site 760011002411 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 760011002412 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 760011002413 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 760011002414 active site 760011002415 catalytic residue [active] 760011002416 dimer interface [polypeptide binding]; other site 760011002417 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 760011002418 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 760011002419 shikimate binding site; other site 760011002420 NAD(P) binding site [chemical binding]; other site 760011002421 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 760011002422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011002423 Walker A/P-loop; other site 760011002424 ATP binding site [chemical binding]; other site 760011002425 Q-loop/lid; other site 760011002426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760011002427 ABC transporter signature motif; other site 760011002428 Walker B; other site 760011002429 D-loop; other site 760011002430 ABC transporter; Region: ABC_tran_2; pfam12848 760011002431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 760011002432 Maf-like protein; Region: Maf; pfam02545 760011002433 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 760011002434 active site 760011002435 dimer interface [polypeptide binding]; other site 760011002436 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 760011002437 rRNA interaction site [nucleotide binding]; other site 760011002438 S8 interaction site; other site 760011002439 putative laminin-1 binding site; other site 760011002440 translation elongation factor Ts; Region: tsf; TIGR00116 760011002441 UBA/TS-N domain; Region: UBA; pfam00627 760011002442 Elongation factor TS; Region: EF_TS; pfam00889 760011002443 Elongation factor TS; Region: EF_TS; pfam00889 760011002444 ribosome recycling factor; Reviewed; Region: frr; PRK00083 760011002445 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 760011002446 hinge region; other site 760011002447 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 760011002448 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 760011002449 catalytic residue [active] 760011002450 putative FPP diphosphate binding site; other site 760011002451 putative FPP binding hydrophobic cleft; other site 760011002452 dimer interface [polypeptide binding]; other site 760011002453 putative IPP diphosphate binding site; other site 760011002454 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 760011002455 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 760011002456 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 760011002457 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 760011002458 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 760011002459 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 760011002460 RIP metalloprotease RseP; Region: TIGR00054 760011002461 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 760011002462 active site 760011002463 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760011002464 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 760011002465 protein binding site [polypeptide binding]; other site 760011002466 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 760011002467 putative substrate binding region [chemical binding]; other site 760011002468 replicative DNA helicase; Region: DnaB; TIGR00665 760011002469 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 760011002470 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 760011002471 Walker A motif; other site 760011002472 ATP binding site [chemical binding]; other site 760011002473 Walker B motif; other site 760011002474 DNA binding loops [nucleotide binding] 760011002475 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 760011002476 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 760011002477 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 760011002478 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 760011002479 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760011002480 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760011002481 dimer interface [polypeptide binding]; other site 760011002482 ssDNA binding site [nucleotide binding]; other site 760011002483 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760011002484 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 760011002485 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 760011002486 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 760011002487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760011002488 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760011002489 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 760011002490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 760011002491 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 760011002492 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 760011002493 active site 760011002494 HIGH motif; other site 760011002495 KMSKS motif; other site 760011002496 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 760011002497 tRNA binding surface [nucleotide binding]; other site 760011002498 anticodon binding site; other site 760011002499 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 760011002500 putative tRNA-binding site [nucleotide binding]; other site 760011002501 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 760011002502 HflK protein; Region: hflK; TIGR01933 760011002503 HflC protein; Region: hflC; TIGR01932 760011002504 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 760011002505 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 760011002506 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760011002507 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760011002508 Walker A/P-loop; other site 760011002509 ATP binding site [chemical binding]; other site 760011002510 Q-loop/lid; other site 760011002511 ABC transporter signature motif; other site 760011002512 Walker B; other site 760011002513 D-loop; other site 760011002514 H-loop/switch region; other site 760011002515 argininosuccinate synthase; Provisional; Region: PRK13820 760011002516 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 760011002517 ANP binding site [chemical binding]; other site 760011002518 Substrate Binding Site II [chemical binding]; other site 760011002519 Substrate Binding Site I [chemical binding]; other site 760011002520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 760011002521 dimerization interface [polypeptide binding]; other site 760011002522 putative DNA binding site [nucleotide binding]; other site 760011002523 putative Zn2+ binding site [ion binding]; other site 760011002524 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 760011002525 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 760011002526 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 760011002527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011002528 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002530 dimer interface [polypeptide binding]; other site 760011002531 conserved gate region; other site 760011002532 putative PBP binding loops; other site 760011002533 ABC-ATPase subunit interface; other site 760011002534 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002536 dimer interface [polypeptide binding]; other site 760011002537 conserved gate region; other site 760011002538 ABC-ATPase subunit interface; other site 760011002539 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 760011002540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011002541 DNA-binding site [nucleotide binding]; DNA binding site 760011002542 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011002543 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011002544 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760011002545 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760011002546 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760011002547 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 760011002548 active site 760011002549 catalytic triad [active] 760011002550 oxyanion hole [active] 760011002551 Probable beta-xylosidase; Provisional; Region: PLN03080 760011002552 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 760011002553 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 760011002554 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011002555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002556 dimer interface [polypeptide binding]; other site 760011002557 conserved gate region; other site 760011002558 putative PBP binding loops; other site 760011002559 ABC-ATPase subunit interface; other site 760011002560 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002562 dimer interface [polypeptide binding]; other site 760011002563 putative PBP binding loops; other site 760011002564 ABC-ATPase subunit interface; other site 760011002565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011002566 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 760011002567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760011002568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011002569 active site 760011002570 phosphorylation site [posttranslational modification] 760011002571 intermolecular recognition site; other site 760011002572 dimerization interface [polypeptide binding]; other site 760011002573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760011002574 DNA binding residues [nucleotide binding] 760011002575 dimerization interface [polypeptide binding]; other site 760011002576 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011002577 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011002578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 760011002579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011002580 ATP binding site [chemical binding]; other site 760011002581 Mg2+ binding site [ion binding]; other site 760011002582 G-X-G motif; other site 760011002583 adenylate kinase; Reviewed; Region: adk; PRK00279 760011002584 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 760011002585 AMP-binding site [chemical binding]; other site 760011002586 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 760011002587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011002588 active site 760011002589 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760011002590 binding surface 760011002591 TPR motif; other site 760011002592 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 760011002593 RNA/DNA hybrid binding site [nucleotide binding]; other site 760011002594 active site 760011002595 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 760011002596 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 760011002597 putative active site; other site 760011002598 putative metal binding residues [ion binding]; other site 760011002599 signature motif; other site 760011002600 putative triphosphate binding site [ion binding]; other site 760011002601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011002602 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011002603 putative substrate translocation pore; other site 760011002604 Divergent PAP2 family; Region: DUF212; pfam02681 760011002605 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760011002606 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760011002607 substrate binding pocket [chemical binding]; other site 760011002608 membrane-bound complex binding site; other site 760011002609 hinge residues; other site 760011002610 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760011002611 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 760011002612 substrate binding pocket [chemical binding]; other site 760011002613 membrane-bound complex binding site; other site 760011002614 hinge residues; other site 760011002615 Helix-turn-helix domain; Region: HTH_38; pfam13936 760011002616 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 760011002617 Integrase core domain; Region: rve; pfam00665 760011002618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002619 dimer interface [polypeptide binding]; other site 760011002620 conserved gate region; other site 760011002621 putative PBP binding loops; other site 760011002622 ABC-ATPase subunit interface; other site 760011002623 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760011002624 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 760011002625 Walker A/P-loop; other site 760011002626 ATP binding site [chemical binding]; other site 760011002627 Q-loop/lid; other site 760011002628 ABC transporter signature motif; other site 760011002629 Walker B; other site 760011002630 D-loop; other site 760011002631 H-loop/switch region; other site 760011002632 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760011002633 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 760011002634 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 760011002635 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 760011002636 Part of AAA domain; Region: AAA_19; pfam13245 760011002637 Family description; Region: UvrD_C_2; pfam13538 760011002638 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760011002639 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760011002640 P-loop; other site 760011002641 Magnesium ion binding site [ion binding]; other site 760011002642 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760011002643 Magnesium ion binding site [ion binding]; other site 760011002644 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 760011002645 beta-galactosidase; Region: BGL; TIGR03356 760011002646 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 760011002647 active site 760011002648 putative catalytic site [active] 760011002649 DNA binding site [nucleotide binding] 760011002650 putative phosphate binding site [ion binding]; other site 760011002651 metal binding site A [ion binding]; metal-binding site 760011002652 AP binding site [nucleotide binding]; other site 760011002653 metal binding site B [ion binding]; metal-binding site 760011002654 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 760011002655 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 760011002656 G1 box; other site 760011002657 putative GEF interaction site [polypeptide binding]; other site 760011002658 GTP/Mg2+ binding site [chemical binding]; other site 760011002659 Switch I region; other site 760011002660 G2 box; other site 760011002661 G3 box; other site 760011002662 Switch II region; other site 760011002663 G4 box; other site 760011002664 G5 box; other site 760011002665 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 760011002666 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 760011002667 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 760011002668 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 760011002669 Coenzyme A binding pocket [chemical binding]; other site 760011002670 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760011002671 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 760011002672 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760011002673 Beta-Casp domain; Region: Beta-Casp; smart01027 760011002674 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 760011002675 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 760011002676 active site 760011002677 phosphorylation site [posttranslational modification] 760011002678 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 760011002679 Ligand Binding Site [chemical binding]; other site 760011002680 ATP synthase subunit D; Region: ATP-synt_D; cl00613 760011002681 V-type ATP synthase subunit B; Provisional; Region: PRK04196 760011002682 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760011002683 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 760011002684 Walker A motif homologous position; other site 760011002685 Walker B motif; other site 760011002686 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760011002687 V-type ATP synthase subunit A; Provisional; Region: PRK04192 760011002688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 760011002689 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 760011002690 Walker A motif/ATP binding site; other site 760011002691 Walker B motif; other site 760011002692 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 760011002693 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 760011002694 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 760011002695 Archaeal/vacuolar-type H+-ATPase subunit F [Energy production and conversion]; Region: NtpG; COG1436 760011002696 ATP synthase subunit C; Region: ATP-synt_C; cl00466 760011002697 V-type ATP synthase subunit I; Validated; Region: PRK05771 760011002698 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 760011002699 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 760011002700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 760011002701 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 760011002702 Probable transposase; Region: OrfB_IS605; pfam01385 760011002703 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 760011002704 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 760011002705 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 760011002706 DNA binding residues [nucleotide binding] 760011002707 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 760011002708 catalytic residues [active] 760011002709 catalytic nucleophile [active] 760011002710 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 760011002711 Fic/DOC family; Region: Fic; cl00960 760011002712 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 760011002713 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 760011002714 Ca binding site [ion binding]; other site 760011002715 active site 760011002716 catalytic site [active] 760011002717 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 760011002718 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 760011002719 Melibiase; Region: Melibiase; pfam02065 760011002720 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 760011002721 beta-galactosidase; Region: BGL; TIGR03356 760011002722 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 760011002723 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 760011002724 AzlC protein; Region: AzlC; pfam03591 760011002725 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 760011002726 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 760011002727 putative ligand binding site [chemical binding]; other site 760011002728 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760011002729 active site 760011002730 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 760011002731 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 760011002732 active site 760011002733 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760011002734 substrate binding site [chemical binding]; other site 760011002735 catalytic residues [active] 760011002736 dimer interface [polypeptide binding]; other site 760011002737 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 760011002738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011002739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011002740 homodimer interface [polypeptide binding]; other site 760011002741 catalytic residue [active] 760011002742 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 760011002743 dihydrodipicolinate synthase; Region: dapA; TIGR00674 760011002744 dimer interface [polypeptide binding]; other site 760011002745 active site 760011002746 catalytic residue [active] 760011002747 dihydrodipicolinate reductase; Provisional; Region: PRK00048 760011002748 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 760011002749 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 760011002750 DNA topoisomerase III; Provisional; Region: PRK07726 760011002751 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 760011002752 active site 760011002753 putative interdomain interaction site [polypeptide binding]; other site 760011002754 putative metal-binding site [ion binding]; other site 760011002755 putative nucleotide binding site [chemical binding]; other site 760011002756 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 760011002757 domain I; other site 760011002758 DNA binding groove [nucleotide binding] 760011002759 phosphate binding site [ion binding]; other site 760011002760 domain II; other site 760011002761 domain III; other site 760011002762 nucleotide binding site [chemical binding]; other site 760011002763 catalytic site [active] 760011002764 domain IV; other site 760011002765 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 760011002766 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 760011002767 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 760011002768 generic binding surface I; other site 760011002769 generic binding surface II; other site 760011002770 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 760011002771 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 760011002772 DJ-1 family protein; Region: not_thiJ; TIGR01383 760011002773 conserved cys residue [active] 760011002774 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 760011002775 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 760011002776 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760011002777 active site 760011002778 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011002779 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011002780 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011002781 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011002782 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011002783 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011002784 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011002785 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011002786 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011002787 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011002788 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 760011002789 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 760011002790 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 760011002791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011002792 Walker A motif; other site 760011002793 ATP binding site [chemical binding]; other site 760011002794 Walker B motif; other site 760011002795 arginine finger; other site 760011002796 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 760011002797 trigger factor; Provisional; Region: tig; PRK01490 760011002798 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760011002799 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 760011002800 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 760011002801 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 760011002802 oligomer interface [polypeptide binding]; other site 760011002803 active site residues [active] 760011002804 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 760011002805 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 760011002806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011002807 Walker A motif; other site 760011002808 ATP binding site [chemical binding]; other site 760011002809 Walker B motif; other site 760011002810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 760011002811 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 760011002812 DHH family; Region: DHH; pfam01368 760011002813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 760011002814 active site 760011002815 dimerization interface [polypeptide binding]; other site 760011002816 oligoendopeptidase F; Region: pepF; TIGR00181 760011002817 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 760011002818 active site 760011002819 Zn binding site [ion binding]; other site 760011002820 Helix-turn-helix domain; Region: HTH_17; cl17695 760011002821 Domain of unknown function (DUF4301); Region: DUF4301; pfam14134 760011002822 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 760011002823 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 760011002824 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 760011002825 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 760011002826 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 760011002827 Protein of unknown function (DUF935); Region: DUF935; pfam06074 760011002828 Terminase-like family; Region: Terminase_6; pfam03237 760011002829 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 760011002830 Beta protein; Region: Beta_protein; pfam14350 760011002831 Predicted transcriptional regulator [Transcription]; Region: COG2932 760011002832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760011002833 non-specific DNA binding site [nucleotide binding]; other site 760011002834 salt bridge; other site 760011002835 sequence-specific DNA binding site [nucleotide binding]; other site 760011002836 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760011002837 Catalytic site [active] 760011002838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760011002839 sequence-specific DNA binding site [nucleotide binding]; other site 760011002840 salt bridge; other site 760011002841 Bacteriophage Mu transposase; Region: DDE_2; pfam02914 760011002842 AAA domain; Region: AAA_22; pfam13401 760011002843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 760011002844 Walker A motif; other site 760011002845 ATP binding site [chemical binding]; other site 760011002846 Walker B motif; other site 760011002847 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 760011002848 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 760011002849 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 760011002850 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 760011002851 DNA binding site [nucleotide binding] 760011002852 active site 760011002853 Int/Topo IB signature motif; other site 760011002854 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760011002855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 760011002856 active site 760011002857 metal binding site [ion binding]; metal-binding site 760011002858 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 760011002859 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760011002860 minor groove reading motif; other site 760011002861 helix-hairpin-helix signature motif; other site 760011002862 substrate binding pocket [chemical binding]; other site 760011002863 active site 760011002864 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 760011002865 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 760011002866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011002867 FeS/SAM binding site; other site 760011002868 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 760011002869 ATP cone domain; Region: ATP-cone; pfam03477 760011002870 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 760011002871 Class III ribonucleotide reductase; Region: RNR_III; cd01675 760011002872 active site 760011002873 Zn binding site [ion binding]; other site 760011002874 glycine loop; other site 760011002875 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760011002876 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 760011002877 Walker A/P-loop; other site 760011002878 ATP binding site [chemical binding]; other site 760011002879 Q-loop/lid; other site 760011002880 ABC transporter signature motif; other site 760011002881 Walker B; other site 760011002882 D-loop; other site 760011002883 H-loop/switch region; other site 760011002884 TOBE domain; Region: TOBE_2; pfam08402 760011002885 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011002886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002887 dimer interface [polypeptide binding]; other site 760011002888 conserved gate region; other site 760011002889 putative PBP binding loops; other site 760011002890 ABC-ATPase subunit interface; other site 760011002891 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760011002892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002893 dimer interface [polypeptide binding]; other site 760011002894 conserved gate region; other site 760011002895 putative PBP binding loops; other site 760011002896 ABC-ATPase subunit interface; other site 760011002897 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 760011002898 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 760011002899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760011002900 Coenzyme A binding pocket [chemical binding]; other site 760011002901 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 760011002902 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 760011002903 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760011002904 Domain of unknown function (DUF386); Region: DUF386; cl01047 760011002905 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 760011002906 glutamyl-tRNA reductase; Region: hemA; TIGR01035 760011002907 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 760011002908 NAD(P) binding pocket [chemical binding]; other site 760011002909 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 760011002910 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 760011002911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760011002912 minor groove reading motif; other site 760011002913 helix-hairpin-helix signature motif; other site 760011002914 active site 760011002915 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 760011002916 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 760011002917 dimerization interface [polypeptide binding]; other site 760011002918 ATP binding site [chemical binding]; other site 760011002919 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 760011002920 dimerization interface [polypeptide binding]; other site 760011002921 ATP binding site [chemical binding]; other site 760011002922 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 760011002923 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 760011002924 dimerization interface [polypeptide binding]; other site 760011002925 putative ATP binding site [chemical binding]; other site 760011002926 phosphoribosylformylglycinamidine synthase I; Region: FGAM_synth_I; TIGR01737 760011002927 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 760011002928 conserved cys residue [active] 760011002929 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 760011002930 active site 760011002931 ATP binding site [chemical binding]; other site 760011002932 substrate binding site [chemical binding]; other site 760011002933 AIR carboxylase; Region: AIRC; cl00310 760011002934 amidophosphoribosyltransferase; Provisional; Region: PRK09246 760011002935 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 760011002936 active site 760011002937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011002938 active site 760011002939 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 760011002940 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 760011002941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011002942 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 760011002943 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 760011002944 active site 760011002945 substrate binding site [chemical binding]; other site 760011002946 cosubstrate binding site; other site 760011002947 catalytic site [active] 760011002948 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 760011002949 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 760011002950 homotrimer interaction site [polypeptide binding]; other site 760011002951 putative active site [active] 760011002952 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 760011002953 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011002954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002955 dimer interface [polypeptide binding]; other site 760011002956 conserved gate region; other site 760011002957 putative PBP binding loops; other site 760011002958 ABC-ATPase subunit interface; other site 760011002959 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011002960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011002961 dimer interface [polypeptide binding]; other site 760011002962 conserved gate region; other site 760011002963 putative PBP binding loops; other site 760011002964 ABC-ATPase subunit interface; other site 760011002965 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011002966 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011002967 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 760011002968 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 760011002969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011002970 catalytic residue [active] 760011002971 LabA_like proteins; Region: LabA_like; cd06167 760011002972 putative metal binding site [ion binding]; other site 760011002973 TM2 domain; Region: TM2; pfam05154 760011002974 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 760011002975 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 760011002976 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760011002977 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 760011002978 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 760011002979 propionate/acetate kinase; Provisional; Region: PRK12379 760011002980 DJ-1 family protein; Region: not_thiJ; TIGR01383 760011002981 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 760011002982 conserved cys residue [active] 760011002983 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 760011002984 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 760011002985 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760011002986 Tetratricopeptide repeat; Region: TPR_12; pfam13424 760011002987 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760011002988 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 760011002989 putative ligand binding site [chemical binding]; other site 760011002990 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 760011002991 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 760011002992 TM-ABC transporter signature motif; other site 760011002993 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 760011002994 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 760011002995 TM-ABC transporter signature motif; other site 760011002996 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 760011002997 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 760011002998 Walker A/P-loop; other site 760011002999 ATP binding site [chemical binding]; other site 760011003000 Q-loop/lid; other site 760011003001 ABC transporter signature motif; other site 760011003002 Walker B; other site 760011003003 D-loop; other site 760011003004 H-loop/switch region; other site 760011003005 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 760011003006 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 760011003007 Walker A/P-loop; other site 760011003008 ATP binding site [chemical binding]; other site 760011003009 Q-loop/lid; other site 760011003010 ABC transporter signature motif; other site 760011003011 Walker B; other site 760011003012 D-loop; other site 760011003013 H-loop/switch region; other site 760011003014 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 760011003015 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760011003016 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 760011003017 acyl-activating enzyme (AAE) consensus motif; other site 760011003018 acyl-activating enzyme (AAE) consensus motif; other site 760011003019 putative AMP binding site [chemical binding]; other site 760011003020 putative active site [active] 760011003021 putative CoA binding site [chemical binding]; other site 760011003022 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 760011003023 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 760011003024 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 760011003025 putative dimer interface [polypeptide binding]; other site 760011003026 putative anticodon binding site; other site 760011003027 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 760011003028 homodimer interface [polypeptide binding]; other site 760011003029 motif 1; other site 760011003030 motif 2; other site 760011003031 active site 760011003032 motif 3; other site 760011003033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760011003034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760011003035 DNA binding residues [nucleotide binding] 760011003036 dimerization interface [polypeptide binding]; other site 760011003037 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 760011003038 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 760011003039 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 760011003040 active site 760011003041 ADP/pyrophosphate binding site [chemical binding]; other site 760011003042 dimerization interface [polypeptide binding]; other site 760011003043 allosteric effector site; other site 760011003044 fructose-1,6-bisphosphate binding site; other site 760011003045 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 760011003046 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760011003047 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760011003048 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH5; cd08189 760011003049 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 760011003050 putative active site [active] 760011003051 metal binding site [ion binding]; metal-binding site 760011003052 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 760011003053 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 760011003054 NAD(P) binding site [chemical binding]; other site 760011003055 catalytic residues [active] 760011003056 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011003057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011003058 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011003059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003060 dimer interface [polypeptide binding]; other site 760011003061 conserved gate region; other site 760011003062 putative PBP binding loops; other site 760011003063 ABC-ATPase subunit interface; other site 760011003064 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011003065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003066 dimer interface [polypeptide binding]; other site 760011003067 conserved gate region; other site 760011003068 putative PBP binding loops; other site 760011003069 ABC-ATPase subunit interface; other site 760011003070 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760011003071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011003072 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760011003073 nucleotide binding site [chemical binding]; other site 760011003074 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 760011003075 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 760011003076 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 760011003077 active site 760011003078 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 760011003079 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 760011003080 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 760011003081 acyl-activating enzyme (AAE) consensus motif; other site 760011003082 putative AMP binding site [chemical binding]; other site 760011003083 putative active site [active] 760011003084 putative CoA binding site [chemical binding]; other site 760011003085 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 760011003086 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760011003087 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 760011003088 Domain of unknown function (DUF814); Region: DUF814; pfam05670 760011003089 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 760011003090 active site 760011003091 metal binding site [ion binding]; metal-binding site 760011003092 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 760011003093 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 760011003094 cytidylate kinase; Provisional; Region: PRK04182 760011003095 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 760011003096 CMP-binding site; other site 760011003097 The sites determining sugar specificity; other site 760011003098 hypothetical protein; Provisional; Region: PRK11820 760011003099 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 760011003100 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 760011003101 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 760011003102 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760011003103 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 760011003104 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 760011003105 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 760011003106 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 760011003107 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 760011003108 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 760011003109 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011003110 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 760011003111 active site 760011003112 DNA polymerase IV; Validated; Region: PRK02406 760011003113 DNA binding site [nucleotide binding] 760011003114 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 760011003115 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 760011003116 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 760011003117 seryl-tRNA synthetase; Provisional; Region: PRK05431 760011003118 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 760011003119 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 760011003120 dimer interface [polypeptide binding]; other site 760011003121 active site 760011003122 motif 1; other site 760011003123 motif 2; other site 760011003124 motif 3; other site 760011003125 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 760011003126 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 760011003127 active site 760011003128 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 760011003129 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 760011003130 active site 760011003131 metal binding site [ion binding]; metal-binding site 760011003132 gamma-glutamyl kinase; Provisional; Region: PRK05429 760011003133 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 760011003134 nucleotide binding site [chemical binding]; other site 760011003135 homotetrameric interface [polypeptide binding]; other site 760011003136 putative phosphate binding site [ion binding]; other site 760011003137 putative allosteric binding site; other site 760011003138 PUA domain; Region: PUA; pfam01472 760011003139 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 760011003140 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 760011003141 putative catalytic cysteine [active] 760011003142 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 760011003143 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 760011003144 active site 760011003145 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 760011003146 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 760011003147 intersubunit interface [polypeptide binding]; other site 760011003148 active site 760011003149 zinc binding site [ion binding]; other site 760011003150 Na+ binding site [ion binding]; other site 760011003151 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 760011003152 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760011003153 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 760011003154 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 760011003155 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 760011003156 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 760011003157 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 760011003158 23S rRNA binding site [nucleotide binding]; other site 760011003159 L21 binding site [polypeptide binding]; other site 760011003160 L13 binding site [polypeptide binding]; other site 760011003161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 760011003162 binding surface 760011003163 TPR motif; other site 760011003164 TPR repeat; Region: TPR_11; pfam13414 760011003165 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 760011003166 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 760011003167 Glycoprotease family; Region: Peptidase_M22; pfam00814 760011003168 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 760011003169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 760011003170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760011003171 glycogen synthase; Provisional; Region: glgA; PRK00654 760011003172 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 760011003173 ADP-binding pocket [chemical binding]; other site 760011003174 homodimer interface [polypeptide binding]; other site 760011003175 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 760011003176 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 760011003177 ligand binding site; other site 760011003178 oligomer interface; other site 760011003179 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 760011003180 dimer interface [polypeptide binding]; other site 760011003181 N-terminal domain interface [polypeptide binding]; other site 760011003182 sulfate 1 binding site; other site 760011003183 Uncharacterized conserved protein [Function unknown]; Region: COG0062 760011003184 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 760011003185 putative substrate binding site [chemical binding]; other site 760011003186 putative ATP binding site [chemical binding]; other site 760011003187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760011003188 non-specific DNA binding site [nucleotide binding]; other site 760011003189 salt bridge; other site 760011003190 sequence-specific DNA binding site [nucleotide binding]; other site 760011003191 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011003192 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 760011003193 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 760011003194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003195 dimer interface [polypeptide binding]; other site 760011003196 conserved gate region; other site 760011003197 putative PBP binding loops; other site 760011003198 ABC-ATPase subunit interface; other site 760011003199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003200 dimer interface [polypeptide binding]; other site 760011003201 conserved gate region; other site 760011003202 putative PBP binding loops; other site 760011003203 ABC-ATPase subunit interface; other site 760011003204 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 760011003205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011003206 Walker A/P-loop; other site 760011003207 ATP binding site [chemical binding]; other site 760011003208 Q-loop/lid; other site 760011003209 ABC transporter signature motif; other site 760011003210 Walker B; other site 760011003211 D-loop; other site 760011003212 H-loop/switch region; other site 760011003213 excinuclease ABC subunit B; Provisional; Region: PRK05298 760011003214 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 760011003215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011003216 ATP-binding site [chemical binding]; other site 760011003217 ATP binding site [chemical binding]; other site 760011003218 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011003219 nucleotide binding region [chemical binding]; other site 760011003220 ATP-binding site [chemical binding]; other site 760011003221 Ultra-violet resistance protein B; Region: UvrB; pfam12344 760011003222 UvrB/uvrC motif; Region: UVR; pfam02151 760011003223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 760011003224 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 760011003225 protein binding site [polypeptide binding]; other site 760011003226 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 760011003227 ApbE family; Region: ApbE; pfam02424 760011003228 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 760011003229 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760011003230 putative substrate binding site [chemical binding]; other site 760011003231 putative ATP binding site [chemical binding]; other site 760011003232 HD supefamily hydrolase [General function prediction only]; Region: COG3294 760011003233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011003234 Zn2+ binding site [ion binding]; other site 760011003235 Mg2+ binding site [ion binding]; other site 760011003236 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 760011003237 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011003238 active site 760011003239 HIGH motif; other site 760011003240 nucleotide binding site [chemical binding]; other site 760011003241 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 760011003242 KMSKS motif; other site 760011003243 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 760011003244 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011003245 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011003246 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 760011003247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003248 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003249 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003250 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003251 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003252 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003253 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003254 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003255 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760011003256 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760011003257 DNA binding residues [nucleotide binding] 760011003258 dimerization interface [polypeptide binding]; other site 760011003259 Rubrerythrin [Energy production and conversion]; Region: COG1592 760011003260 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 760011003261 binuclear metal center [ion binding]; other site 760011003262 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 760011003263 iron binding site [ion binding]; other site 760011003264 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 760011003265 metal binding site 2 [ion binding]; metal-binding site 760011003266 putative DNA binding helix; other site 760011003267 metal binding site 1 [ion binding]; metal-binding site 760011003268 dimer interface [polypeptide binding]; other site 760011003269 structural Zn2+ binding site [ion binding]; other site 760011003270 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 760011003271 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760011003272 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 760011003273 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 760011003274 active site 760011003275 substrate binding site [chemical binding]; other site 760011003276 metal binding site [ion binding]; metal-binding site 760011003277 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 760011003278 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 760011003279 NAD binding site [chemical binding]; other site 760011003280 homodimer interface [polypeptide binding]; other site 760011003281 active site 760011003282 substrate binding site [chemical binding]; other site 760011003283 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 760011003284 MarR family; Region: MarR_2; pfam12802 760011003285 FeoA domain; Region: FeoA; pfam04023 760011003286 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 760011003287 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 760011003288 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 760011003289 G1 box; other site 760011003290 GTP/Mg2+ binding site [chemical binding]; other site 760011003291 Switch I region; other site 760011003292 G2 box; other site 760011003293 G3 box; other site 760011003294 Switch II region; other site 760011003295 G4 box; other site 760011003296 G5 box; other site 760011003297 Nucleoside recognition; Region: Gate; pfam07670 760011003298 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 760011003299 Nucleoside recognition; Region: Gate; pfam07670 760011003300 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 760011003301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760011003302 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760011003303 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760011003304 active site 760011003305 metal binding site [ion binding]; metal-binding site 760011003306 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 760011003307 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 760011003308 active site 760011003309 metal binding site [ion binding]; metal-binding site 760011003310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 760011003311 Haemolytic domain; Region: Haemolytic; pfam01809 760011003312 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 760011003313 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 760011003314 Sugar specificity; other site 760011003315 Pyrimidine base specificity; other site 760011003316 ATP-binding site [chemical binding]; other site 760011003317 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 760011003318 active site 760011003319 catalytic residues [active] 760011003320 GTP-binding protein LepA; Provisional; Region: PRK05433 760011003321 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 760011003322 G1 box; other site 760011003323 putative GEF interaction site [polypeptide binding]; other site 760011003324 GTP/Mg2+ binding site [chemical binding]; other site 760011003325 Switch I region; other site 760011003326 G2 box; other site 760011003327 G3 box; other site 760011003328 Switch II region; other site 760011003329 G4 box; other site 760011003330 G5 box; other site 760011003331 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 760011003332 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 760011003333 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 760011003334 FtsH Extracellular; Region: FtsH_ext; pfam06480 760011003335 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 760011003336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011003337 Walker A motif; other site 760011003338 ATP binding site [chemical binding]; other site 760011003339 Walker B motif; other site 760011003340 arginine finger; other site 760011003341 Peptidase family M41; Region: Peptidase_M41; pfam01434 760011003342 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 760011003343 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 760011003344 Ligand Binding Site [chemical binding]; other site 760011003345 TilS substrate C-terminal domain; Region: TilS_C; cl17443 760011003346 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 760011003347 putative active site [active] 760011003348 catalytic residue [active] 760011003349 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 760011003350 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 760011003351 5S rRNA interface [nucleotide binding]; other site 760011003352 CTC domain interface [polypeptide binding]; other site 760011003353 L16 interface [polypeptide binding]; other site 760011003354 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 760011003355 SpoVG; Region: SpoVG; cl00915 760011003356 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 760011003357 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 760011003358 ligand binding site [chemical binding]; other site 760011003359 active site 760011003360 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 760011003361 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 760011003362 acyl-activating enzyme (AAE) consensus motif; other site 760011003363 putative AMP binding site [chemical binding]; other site 760011003364 putative active site [active] 760011003365 putative CoA binding site [chemical binding]; other site 760011003366 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 760011003367 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 760011003368 active site 760011003369 putative substrate binding pocket [chemical binding]; other site 760011003370 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 760011003371 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 760011003372 active site 760011003373 HIGH motif; other site 760011003374 dimer interface [polypeptide binding]; other site 760011003375 KMSKS motif; other site 760011003376 glycyl-tRNA synthetase; Provisional; Region: PRK04173 760011003377 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 760011003378 dimer interface [polypeptide binding]; other site 760011003379 motif 1; other site 760011003380 active site 760011003381 motif 2; other site 760011003382 motif 3; other site 760011003383 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 760011003384 anticodon binding site; other site 760011003385 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 760011003386 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760011003387 active site 760011003388 HIGH motif; other site 760011003389 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 760011003390 active site 760011003391 KMSKS motif; other site 760011003392 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 760011003393 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760011003394 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 760011003395 nucleophilic elbow; other site 760011003396 catalytic triad; other site 760011003397 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760011003398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760011003399 DNA binding residues [nucleotide binding] 760011003400 dimerization interface [polypeptide binding]; other site 760011003401 RloB-like protein; Region: RloB; pfam13707 760011003402 AAA domain; Region: AAA_21; pfam13304 760011003403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011003404 Walker A/P-loop; other site 760011003405 ATP binding site [chemical binding]; other site 760011003406 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011003407 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011003408 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003409 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003410 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003411 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003412 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003413 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003414 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003415 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003416 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003417 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003418 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 760011003419 zinc binding site [ion binding]; other site 760011003420 putative ligand binding site [chemical binding]; other site 760011003421 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 760011003422 zinc binding site [ion binding]; other site 760011003423 putative ligand binding site [chemical binding]; other site 760011003424 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 760011003425 zinc binding site [ion binding]; other site 760011003426 putative ligand binding site [chemical binding]; other site 760011003427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003428 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 760011003429 TM-ABC transporter signature motif; other site 760011003430 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 760011003431 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011003432 Walker A/P-loop; other site 760011003433 ATP binding site [chemical binding]; other site 760011003434 Q-loop/lid; other site 760011003435 ABC transporter signature motif; other site 760011003436 Walker B; other site 760011003437 D-loop; other site 760011003438 H-loop/switch region; other site 760011003439 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760011003440 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 760011003441 Oligomerisation domain; Region: Oligomerisation; pfam02410 760011003442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 760011003443 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 760011003444 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 760011003445 active site 760011003446 (T/H)XGH motif; other site 760011003447 GTPase CgtA; Reviewed; Region: obgE; PRK12299 760011003448 GTP1/OBG; Region: GTP1_OBG; pfam01018 760011003449 Obg GTPase; Region: Obg; cd01898 760011003450 G1 box; other site 760011003451 GTP/Mg2+ binding site [chemical binding]; other site 760011003452 Switch I region; other site 760011003453 G2 box; other site 760011003454 G3 box; other site 760011003455 Switch II region; other site 760011003456 G4 box; other site 760011003457 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 760011003458 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 760011003459 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 760011003460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760011003461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760011003462 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 760011003463 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 760011003464 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 760011003465 active site 760011003466 HIGH motif; other site 760011003467 KMSK motif region; other site 760011003468 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760011003469 tRNA binding surface [nucleotide binding]; other site 760011003470 anticodon binding site; other site 760011003471 Biotin operon repressor [Transcription]; Region: BirA; COG1654 760011003472 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 760011003473 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 760011003474 BioY family; Region: BioY; pfam02632 760011003475 serine O-acetyltransferase; Region: cysE; TIGR01172 760011003476 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 760011003477 trimer interface [polypeptide binding]; other site 760011003478 active site 760011003479 substrate binding site [chemical binding]; other site 760011003480 CoA binding site [chemical binding]; other site 760011003481 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760011003482 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 760011003483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011003484 FeS/SAM binding site; other site 760011003485 arogenate dehydrogenase; Region: PLN02256 760011003486 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 760011003487 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 760011003488 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760011003489 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 760011003490 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 760011003491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011003492 S-adenosylmethionine binding site [chemical binding]; other site 760011003493 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 760011003494 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 760011003495 active site 760011003496 substrate binding site [chemical binding]; other site 760011003497 metal binding site [ion binding]; metal-binding site 760011003498 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760011003499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011003500 motif II; other site 760011003501 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 760011003502 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 760011003503 putative RNA binding site [nucleotide binding]; other site 760011003504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011003505 S-adenosylmethionine binding site [chemical binding]; other site 760011003506 Flagellin N-methylase; Region: FliB; pfam03692 760011003507 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 760011003508 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 760011003509 oligomer interface [polypeptide binding]; other site 760011003510 Cl binding site [ion binding]; other site 760011003511 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 760011003512 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 760011003513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 760011003514 active site 760011003515 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760011003516 phosphate binding site [ion binding]; other site 760011003517 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 760011003518 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 760011003519 FAD binding pocket [chemical binding]; other site 760011003520 conserved FAD binding motif [chemical binding]; other site 760011003521 phosphate binding motif [ion binding]; other site 760011003522 beta-alpha-beta structure motif; other site 760011003523 NAD binding pocket [chemical binding]; other site 760011003524 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 760011003525 active site 760011003526 dimer interface [polypeptide binding]; other site 760011003527 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011003528 active site 760011003529 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 760011003530 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 760011003531 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 760011003532 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 760011003533 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 760011003534 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 760011003535 putative deacylase active site [active] 760011003536 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 760011003537 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011003538 motif II; other site 760011003539 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 760011003540 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 760011003541 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011003542 FeS/SAM binding site; other site 760011003543 Uncharacterized conserved protein [Function unknown]; Region: COG0432 760011003544 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003545 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011003546 TM-ABC transporter signature motif; other site 760011003547 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011003548 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011003549 Walker A/P-loop; other site 760011003550 ATP binding site [chemical binding]; other site 760011003551 Q-loop/lid; other site 760011003552 ABC transporter signature motif; other site 760011003553 Walker B; other site 760011003554 D-loop; other site 760011003555 H-loop/switch region; other site 760011003556 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011003557 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011003558 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011003559 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760011003560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760011003561 NAD(P) binding site [chemical binding]; other site 760011003562 active site 760011003563 Transcriptional regulators [Transcription]; Region: FadR; COG2186 760011003564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011003565 DNA-binding site [nucleotide binding]; DNA binding site 760011003566 FCD domain; Region: FCD; pfam07729 760011003567 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 760011003568 classical (c) SDRs; Region: SDR_c; cd05233 760011003569 NAD(P) binding site [chemical binding]; other site 760011003570 active site 760011003571 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 760011003572 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011003573 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011003574 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760011003575 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760011003576 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760011003577 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 760011003578 active site 760011003579 aspartate aminotransferase; Provisional; Region: PRK07568 760011003580 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011003581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011003582 homodimer interface [polypeptide binding]; other site 760011003583 catalytic residue [active] 760011003584 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 760011003585 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 760011003586 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011003587 active site 760011003588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011003589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003590 dimer interface [polypeptide binding]; other site 760011003591 conserved gate region; other site 760011003592 putative PBP binding loops; other site 760011003593 ABC-ATPase subunit interface; other site 760011003594 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760011003595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003596 dimer interface [polypeptide binding]; other site 760011003597 conserved gate region; other site 760011003598 putative PBP binding loops; other site 760011003599 ABC-ATPase subunit interface; other site 760011003600 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011003601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011003602 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 760011003603 homodimer interface [polypeptide binding]; other site 760011003604 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 760011003605 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 760011003606 active site 760011003607 homodimer interface [polypeptide binding]; other site 760011003608 catalytic site [active] 760011003609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011003610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011003611 DNA binding site [nucleotide binding] 760011003612 domain linker motif; other site 760011003613 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011003614 ligand binding site [chemical binding]; other site 760011003615 dimerization interface [polypeptide binding]; other site 760011003616 argininosuccinate lyase; Provisional; Region: PRK00855 760011003617 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 760011003618 active sites [active] 760011003619 tetramer interface [polypeptide binding]; other site 760011003620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760011003621 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760011003622 catalytic residues [active] 760011003623 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 760011003624 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 760011003625 dimer interface [polypeptide binding]; other site 760011003626 ssDNA binding site [nucleotide binding]; other site 760011003627 tetramer (dimer of dimers) interface [polypeptide binding]; other site 760011003628 AAK_UMPK-PyrH-Pf: UMP kinase (UMPK)-Pf, the mostly archaeal uridine monophosphate kinase (uridylate kinase) enzymes that catalyze UMP phosphorylation and play a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back...; Region: AAK_UMPK-PyrH-Pf; cd04253 760011003629 nucleotide binding site [chemical binding]; other site 760011003630 homodimeric interface [polypeptide binding]; other site 760011003631 uridine monophosphate binding site [chemical binding]; other site 760011003632 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760011003633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011003634 FeS/SAM binding site; other site 760011003635 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 760011003636 active site 760011003637 nucleophile elbow; other site 760011003638 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 760011003639 pyridoxal binding site [chemical binding]; other site 760011003640 dimer interface [polypeptide binding]; other site 760011003641 ATP binding site [chemical binding]; other site 760011003642 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 760011003643 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 760011003644 active site 760011003645 substrate binding site [chemical binding]; other site 760011003646 metal binding site [ion binding]; metal-binding site 760011003647 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760011003648 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 760011003649 Hexokinase; Region: Hexokinase_2; pfam03727 760011003650 exonuclease I; Provisional; Region: sbcB; PRK11779 760011003651 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 760011003652 active site 760011003653 catalytic site [active] 760011003654 substrate binding site [chemical binding]; other site 760011003655 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 760011003656 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011003657 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011003658 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003659 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003660 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003661 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003662 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003663 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003664 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011003665 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003666 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011003667 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 760011003668 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 760011003669 substrate-cofactor binding pocket; other site 760011003670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011003671 catalytic residue [active] 760011003672 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 760011003673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760011003674 NAD(P) binding site [chemical binding]; other site 760011003675 active site 760011003676 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 760011003677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 760011003678 non-specific DNA binding site [nucleotide binding]; other site 760011003679 salt bridge; other site 760011003680 sequence-specific DNA binding site [nucleotide binding]; other site 760011003681 Cupin domain; Region: Cupin_2; pfam07883 760011003682 MFS/sugar transport protein; Region: MFS_2; pfam13347 760011003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011003684 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 760011003685 Melibiase; Region: Melibiase; pfam02065 760011003686 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 760011003687 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 760011003688 Ca binding site [ion binding]; other site 760011003689 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003691 dimer interface [polypeptide binding]; other site 760011003692 conserved gate region; other site 760011003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 760011003694 ABC-ATPase subunit interface; other site 760011003695 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011003696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011003697 dimer interface [polypeptide binding]; other site 760011003698 conserved gate region; other site 760011003699 ABC-ATPase subunit interface; other site 760011003700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011003701 Helix-turn-helix domain; Region: HTH_18; pfam12833 760011003702 peptide chain release factor 1; Validated; Region: prfA; PRK00591 760011003703 PCRF domain; Region: PCRF; pfam03462 760011003704 RF-1 domain; Region: RF-1; pfam00472 760011003705 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 760011003706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011003707 S-adenosylmethionine binding site [chemical binding]; other site 760011003708 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 760011003709 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011003710 Zn2+ binding site [ion binding]; other site 760011003711 Mg2+ binding site [ion binding]; other site 760011003712 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 760011003713 synthetase active site [active] 760011003714 NTP binding site [chemical binding]; other site 760011003715 metal binding site [ion binding]; metal-binding site 760011003716 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 760011003717 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 760011003718 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 760011003719 PLD-like domain; Region: PLDc_2; pfam13091 760011003720 putative active site [active] 760011003721 catalytic site [active] 760011003722 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 760011003723 PLD-like domain; Region: PLDc_2; pfam13091 760011003724 putative active site [active] 760011003725 catalytic site [active] 760011003726 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 760011003727 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011003728 motif II; other site 760011003729 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 760011003730 active site 760011003731 catalytic motif [active] 760011003732 Zn binding site [ion binding]; other site 760011003733 serine hydroxymethyltransferase; Provisional; Region: PRK13580 760011003734 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 760011003735 dimer interface [polypeptide binding]; other site 760011003736 active site 760011003737 glycine-pyridoxal phosphate binding site [chemical binding]; other site 760011003738 folate binding site [chemical binding]; other site 760011003739 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 760011003740 rRNA binding site [nucleotide binding]; other site 760011003741 predicted 30S ribosome binding site; other site 760011003742 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 760011003743 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 760011003744 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 760011003745 Smr domain; Region: Smr; pfam01713 760011003746 FOG: CBS domain [General function prediction only]; Region: COG0517 760011003747 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 760011003748 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 760011003749 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 760011003750 Walker A/P-loop; other site 760011003751 ATP binding site [chemical binding]; other site 760011003752 Q-loop/lid; other site 760011003753 ABC transporter signature motif; other site 760011003754 Walker B; other site 760011003755 D-loop; other site 760011003756 H-loop/switch region; other site 760011003757 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 760011003758 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 760011003759 Walker A/P-loop; other site 760011003760 ATP binding site [chemical binding]; other site 760011003761 Q-loop/lid; other site 760011003762 ABC transporter signature motif; other site 760011003763 Walker B; other site 760011003764 D-loop; other site 760011003765 H-loop/switch region; other site 760011003766 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003767 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 760011003768 TM-ABC transporter signature motif; other site 760011003769 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003770 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 760011003771 TM-ABC transporter signature motif; other site 760011003772 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760011003773 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011003774 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 760011003775 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 760011003776 dimer interface [polypeptide binding]; other site 760011003777 FMN binding site [chemical binding]; other site 760011003778 NADPH bind site [chemical binding]; other site 760011003779 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 760011003780 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 760011003781 active site 760011003782 interdomain interaction site; other site 760011003783 putative metal-binding site [ion binding]; other site 760011003784 nucleotide binding site [chemical binding]; other site 760011003785 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 760011003786 domain I; other site 760011003787 phosphate binding site [ion binding]; other site 760011003788 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 760011003789 domain II; other site 760011003790 domain III; other site 760011003791 nucleotide binding site [chemical binding]; other site 760011003792 DNA binding groove [nucleotide binding] 760011003793 catalytic site [active] 760011003794 domain IV; other site 760011003795 GTP-binding protein YchF; Reviewed; Region: PRK09601 760011003796 YchF GTPase; Region: YchF; cd01900 760011003797 G1 box; other site 760011003798 GTP/Mg2+ binding site [chemical binding]; other site 760011003799 Switch I region; other site 760011003800 G2 box; other site 760011003801 Switch II region; other site 760011003802 G3 box; other site 760011003803 G4 box; other site 760011003804 G5 box; other site 760011003805 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 760011003806 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 760011003807 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 760011003808 HflX GTPase family; Region: HflX; cd01878 760011003809 G1 box; other site 760011003810 GTP/Mg2+ binding site [chemical binding]; other site 760011003811 Switch I region; other site 760011003812 G2 box; other site 760011003813 G3 box; other site 760011003814 Switch II region; other site 760011003815 G4 box; other site 760011003816 G5 box; other site 760011003817 OPT oligopeptide transporter protein; Region: OPT; cl14607 760011003818 putative oligopeptide transporter, OPT family; Region: TIGR00733 760011003819 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 760011003820 alanyl-tRNA synthetase; Provisional; Region: PRK01584 760011003821 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 760011003822 motif 1; other site 760011003823 active site 760011003824 motif 2; other site 760011003825 motif 3; other site 760011003826 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760011003827 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 760011003828 DNA protecting protein DprA; Region: dprA; TIGR00732 760011003829 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 760011003830 Isochorismatase family; Region: Isochorismatase; pfam00857 760011003831 catalytic triad [active] 760011003832 conserved cis-peptide bond; other site 760011003833 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 760011003834 active site 760011003835 tetramer interface [polypeptide binding]; other site 760011003836 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 760011003837 FMN binding site [chemical binding]; other site 760011003838 dimer interface [polypeptide binding]; other site 760011003839 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 760011003840 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 760011003841 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003842 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760011003843 TM-ABC transporter signature motif; other site 760011003844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011003845 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 760011003846 TM-ABC transporter signature motif; other site 760011003847 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 760011003848 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011003849 Walker A/P-loop; other site 760011003850 ATP binding site [chemical binding]; other site 760011003851 Q-loop/lid; other site 760011003852 ABC transporter signature motif; other site 760011003853 Walker B; other site 760011003854 D-loop; other site 760011003855 H-loop/switch region; other site 760011003856 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011003857 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 760011003858 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 760011003859 ligand binding site [chemical binding]; other site 760011003860 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760011003861 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760011003862 Walker A/P-loop; other site 760011003863 ATP binding site [chemical binding]; other site 760011003864 Q-loop/lid; other site 760011003865 ABC transporter signature motif; other site 760011003866 Walker B; other site 760011003867 D-loop; other site 760011003868 H-loop/switch region; other site 760011003869 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 760011003870 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 760011003871 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 760011003872 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 760011003873 active site 760011003874 phosphorylation site [posttranslational modification] 760011003875 putative oxidoreductase; Provisional; Region: PRK12831 760011003876 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 760011003877 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760011003878 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760011003879 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 760011003880 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 760011003881 FAD binding pocket [chemical binding]; other site 760011003882 FAD binding motif [chemical binding]; other site 760011003883 phosphate binding motif [ion binding]; other site 760011003884 beta-alpha-beta structure motif; other site 760011003885 NAD binding pocket [chemical binding]; other site 760011003886 Iron coordination center [ion binding]; other site 760011003887 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 760011003888 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 760011003889 putative dimer interface [polypeptide binding]; other site 760011003890 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760011003891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011003892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011003893 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 760011003894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 760011003895 ABC-ATPase subunit interface; other site 760011003896 dimer interface [polypeptide binding]; other site 760011003897 putative PBP binding regions; other site 760011003898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 760011003899 ABC-ATPase subunit interface; other site 760011003900 dimer interface [polypeptide binding]; other site 760011003901 putative PBP binding regions; other site 760011003902 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 760011003903 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 760011003904 Walker A/P-loop; other site 760011003905 ATP binding site [chemical binding]; other site 760011003906 Q-loop/lid; other site 760011003907 ABC transporter signature motif; other site 760011003908 Walker B; other site 760011003909 D-loop; other site 760011003910 H-loop/switch region; other site 760011003911 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 760011003912 intersubunit interface [polypeptide binding]; other site 760011003913 helicase Cas3; Provisional; Region: PRK09694 760011003914 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 760011003915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760011003916 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 760011003917 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 760011003918 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 760011003919 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 760011003920 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 760011003921 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 760011003922 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 760011003923 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 760011003924 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 760011003925 HNH endonuclease; Region: HNH_2; pfam13391 760011003926 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 760011003927 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 760011003928 Divergent AAA domain; Region: AAA_4; pfam04326 760011003929 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760011003930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 760011003931 putative DNA binding site [nucleotide binding]; other site 760011003932 putative Zn2+ binding site [ion binding]; other site 760011003933 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 760011003934 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 760011003935 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 760011003936 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 760011003937 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 760011003938 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 760011003939 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 760011003940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011003941 H+ Antiporter protein; Region: 2A0121; TIGR00900 760011003942 putative substrate translocation pore; other site 760011003943 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760011003944 Divergent AAA domain; Region: AAA_4; pfam04326 760011003945 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 760011003946 AIPR protein; Region: AIPR; pfam10592 760011003947 crystallin beta/gamma motif-containing protein; Region: PHA00657 760011003948 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 760011003949 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 760011003950 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 760011003951 TrkA-N domain; Region: TrkA_N; pfam02254 760011003952 TrkA-C domain; Region: TrkA_C; pfam02080 760011003953 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 760011003954 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 760011003955 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 760011003956 TrkA-N domain; Region: TrkA_N; pfam02254 760011003957 TrkA-C domain; Region: TrkA_C; pfam02080 760011003958 TrkA-N domain; Region: TrkA_N; pfam02254 760011003959 TrkA-C domain; Region: TrkA_C; pfam02080 760011003960 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 760011003961 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 760011003962 A new structural DNA glycosylase; Region: AlkD_like; cd06561 760011003963 active site 760011003964 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 760011003965 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 760011003966 active site 760011003967 dimer interface [polypeptide binding]; other site 760011003968 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 760011003969 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 760011003970 catalytic residues [active] 760011003971 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 760011003972 putative FMN binding site [chemical binding]; other site 760011003973 Uncharacterized conserved protein [Function unknown]; Region: COG1284 760011003974 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760011003975 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 760011003976 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 760011003977 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 760011003978 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 760011003979 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 760011003980 Transcriptional regulators [Transcription]; Region: GntR; COG1802 760011003981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011003982 DNA-binding site [nucleotide binding]; DNA binding site 760011003983 FCD domain; Region: FCD; pfam07729 760011003984 mannonate dehydratase; Provisional; Region: PRK03906 760011003985 mannonate dehydratase; Region: uxuA; TIGR00695 760011003986 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 760011003987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 760011003988 Coenzyme A binding pocket [chemical binding]; other site 760011003989 enolase; Provisional; Region: eno; PRK00077 760011003990 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 760011003991 dimer interface [polypeptide binding]; other site 760011003992 metal binding site [ion binding]; metal-binding site 760011003993 substrate binding pocket [chemical binding]; other site 760011003994 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760011003995 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760011003996 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 760011003997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011003998 recombination regulator RecX; Reviewed; Region: recX; PRK00117 760011003999 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 760011004000 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 760011004001 23S rRNA interface [nucleotide binding]; other site 760011004002 L3 interface [polypeptide binding]; other site 760011004003 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760011004004 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 760011004005 Part of AAA domain; Region: AAA_19; pfam13245 760011004006 Family description; Region: UvrD_C_2; pfam13538 760011004007 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 760011004008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 760011004009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011004010 FeS/SAM binding site; other site 760011004011 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 760011004012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004013 dimer interface [polypeptide binding]; other site 760011004014 conserved gate region; other site 760011004015 putative PBP binding loops; other site 760011004016 ABC-ATPase subunit interface; other site 760011004017 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 760011004018 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 760011004019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004020 dimer interface [polypeptide binding]; other site 760011004021 conserved gate region; other site 760011004022 putative PBP binding loops; other site 760011004023 ABC-ATPase subunit interface; other site 760011004024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 760011004025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760011004026 Walker A/P-loop; other site 760011004027 ATP binding site [chemical binding]; other site 760011004028 Q-loop/lid; other site 760011004029 ABC transporter signature motif; other site 760011004030 Walker B; other site 760011004031 D-loop; other site 760011004032 H-loop/switch region; other site 760011004033 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 760011004034 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 760011004035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 760011004036 Walker A/P-loop; other site 760011004037 ATP binding site [chemical binding]; other site 760011004038 Q-loop/lid; other site 760011004039 ABC transporter signature motif; other site 760011004040 Walker B; other site 760011004041 D-loop; other site 760011004042 H-loop/switch region; other site 760011004043 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 760011004044 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 760011004045 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760011004046 peptide binding site [polypeptide binding]; other site 760011004047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011004048 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 760011004049 Walker A/P-loop; other site 760011004050 ATP binding site [chemical binding]; other site 760011004051 Q-loop/lid; other site 760011004052 ABC transporter signature motif; other site 760011004053 Walker B; other site 760011004054 D-loop; other site 760011004055 H-loop/switch region; other site 760011004056 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 760011004057 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 760011004058 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 760011004059 NAD(P) binding site [chemical binding]; other site 760011004060 LDH/MDH dimer interface [polypeptide binding]; other site 760011004061 substrate binding site [chemical binding]; other site 760011004062 Response regulator receiver domain; Region: Response_reg; pfam00072 760011004063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011004064 active site 760011004065 phosphorylation site [posttranslational modification] 760011004066 intermolecular recognition site; other site 760011004067 dimerization interface [polypeptide binding]; other site 760011004068 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011004069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004071 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004073 dimer interface [polypeptide binding]; other site 760011004074 conserved gate region; other site 760011004075 putative PBP binding loops; other site 760011004076 ABC-ATPase subunit interface; other site 760011004077 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760011004078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004079 dimer interface [polypeptide binding]; other site 760011004080 conserved gate region; other site 760011004081 putative PBP binding loops; other site 760011004082 ABC-ATPase subunit interface; other site 760011004083 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011004084 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011004085 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 760011004086 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 760011004087 putative NADP binding site [chemical binding]; other site 760011004088 putative substrate binding site [chemical binding]; other site 760011004089 active site 760011004090 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 760011004091 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 760011004092 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 760011004093 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 760011004094 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 760011004095 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 760011004096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011004097 catalytic residue [active] 760011004098 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 760011004099 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 760011004100 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011004101 catalytic residue [active] 760011004102 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 760011004103 lipoyl attachment site [posttranslational modification]; other site 760011004104 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 760011004105 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 760011004106 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 760011004107 active site 760011004108 8-oxo-dGMP binding site [chemical binding]; other site 760011004109 nudix motif; other site 760011004110 metal binding site [ion binding]; metal-binding site 760011004111 Predicted permeases [General function prediction only]; Region: COG0679 760011004112 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 760011004113 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 760011004114 phosphate binding site [ion binding]; other site 760011004115 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 760011004116 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 760011004117 methionine sulfoxide reductase A; Provisional; Region: PRK14054 760011004118 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 760011004119 ZIP Zinc transporter; Region: Zip; pfam02535 760011004120 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 760011004121 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 760011004122 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760011004123 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 760011004124 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760011004125 active site 760011004126 metal binding site [ion binding]; metal-binding site 760011004127 homotetramer interface [polypeptide binding]; other site 760011004128 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004129 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004130 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004133 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004134 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004135 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004136 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004137 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004138 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004139 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004140 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004141 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004142 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 760011004143 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 760011004144 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 760011004145 active site 760011004146 Fic family protein [Function unknown]; Region: COG3177 760011004147 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 760011004148 Fic/DOC family; Region: Fic; pfam02661 760011004149 Flagellin N-methylase; Region: FliB; cl00497 760011004150 Survival protein SurE; Region: SurE; pfam01975 760011004151 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 760011004152 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 760011004153 transcription termination factor Rho; Provisional; Region: rho; PRK09376 760011004154 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 760011004155 RNA binding site [nucleotide binding]; other site 760011004156 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 760011004157 multimer interface [polypeptide binding]; other site 760011004158 Walker A motif; other site 760011004159 ATP binding site [chemical binding]; other site 760011004160 Walker B motif; other site 760011004161 competence/damage-inducible protein CinA N-terminal domain; Region: cinA_nterm; TIGR00200 760011004162 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 760011004163 putative MPT binding site; other site 760011004164 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 760011004165 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 760011004166 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 760011004167 putative active site [active] 760011004168 catalytic triad [active] 760011004169 putative dimer interface [polypeptide binding]; other site 760011004170 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 760011004171 IHF - DNA interface [nucleotide binding]; other site 760011004172 IHF dimer interface [polypeptide binding]; other site 760011004173 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 760011004174 PSP1 C-terminal conserved region; Region: PSP1; cl00770 760011004175 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 760011004176 active site 760011004177 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 760011004178 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 760011004179 FMN binding site [chemical binding]; other site 760011004180 active site 760011004181 catalytic residues [active] 760011004182 substrate binding site [chemical binding]; other site 760011004183 Phosphoribosylamine-glycine ligase [Nucleotide transport and metabolism]; Region: PurD; COG0151 760011004184 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 760011004185 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011004186 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 760011004187 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011004188 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004189 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004190 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 760011004191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004192 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004193 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004194 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004195 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004196 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004197 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004198 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004199 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004200 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004201 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004202 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760011004204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760011004205 active site 760011004206 catalytic tetrad [active] 760011004207 Bacterial sugar transferase; Region: Bac_transf; pfam02397 760011004208 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011004209 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004210 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004211 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004212 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004213 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004214 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004215 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004216 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004217 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004218 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004219 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004220 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004222 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 760011004223 Protein of unknown function (DUF1538); Region: DUF1538; pfam07556 760011004224 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 760011004225 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 760011004226 NAD binding site [chemical binding]; other site 760011004227 substrate binding site [chemical binding]; other site 760011004228 homodimer interface [polypeptide binding]; other site 760011004229 active site 760011004230 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 760011004231 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 760011004232 substrate binding site [chemical binding]; other site 760011004233 dimer interface [polypeptide binding]; other site 760011004234 ATP binding site [chemical binding]; other site 760011004235 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011004236 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011004237 TM-ABC transporter signature motif; other site 760011004238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011004239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011004240 TM-ABC transporter signature motif; other site 760011004241 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011004242 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011004243 Walker A/P-loop; other site 760011004244 ATP binding site [chemical binding]; other site 760011004245 Q-loop/lid; other site 760011004246 ABC transporter signature motif; other site 760011004247 Walker B; other site 760011004248 D-loop; other site 760011004249 H-loop/switch region; other site 760011004250 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011004251 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 760011004252 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011004253 ligand binding site [chemical binding]; other site 760011004254 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011004255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011004256 DNA binding site [nucleotide binding] 760011004257 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011004258 ligand binding site [chemical binding]; other site 760011004259 dimerization interface [polypeptide binding]; other site 760011004260 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 760011004261 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 760011004262 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004263 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011004264 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004265 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004266 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004267 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 760011004268 Omptin family; Region: Omptin; cl01886 760011004269 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 760011004270 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 760011004271 active site 760011004272 catalytic triad [active] 760011004273 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 760011004274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011004275 Walker A motif; other site 760011004276 ATP binding site [chemical binding]; other site 760011004277 Walker B motif; other site 760011004278 arginine finger; other site 760011004279 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 760011004280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 760011004281 active site 760011004282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011004283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011004284 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760011004285 Walker A/P-loop; other site 760011004286 ATP binding site [chemical binding]; other site 760011004287 Q-loop/lid; other site 760011004288 ABC transporter signature motif; other site 760011004289 Walker B; other site 760011004290 D-loop; other site 760011004291 H-loop/switch region; other site 760011004292 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011004293 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011004294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011004295 Walker A/P-loop; other site 760011004296 ATP binding site [chemical binding]; other site 760011004297 Q-loop/lid; other site 760011004298 ABC transporter signature motif; other site 760011004299 Walker B; other site 760011004300 D-loop; other site 760011004301 H-loop/switch region; other site 760011004302 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760011004303 MarR family; Region: MarR_2; pfam12802 760011004304 hypothetical protein; Provisional; Region: PRK09273 760011004305 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 760011004306 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 760011004307 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760011004308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011004310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004311 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011004312 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011004313 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 760011004314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004315 dimer interface [polypeptide binding]; other site 760011004316 conserved gate region; other site 760011004317 putative PBP binding loops; other site 760011004318 ABC-ATPase subunit interface; other site 760011004319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011004320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004321 dimer interface [polypeptide binding]; other site 760011004322 conserved gate region; other site 760011004323 putative PBP binding loops; other site 760011004324 ABC-ATPase subunit interface; other site 760011004325 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 760011004326 active site 760011004327 catalytic site [active] 760011004328 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 760011004329 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 760011004330 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 760011004331 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004332 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004333 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004334 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004335 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004336 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004337 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004338 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004339 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004340 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004341 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004342 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004343 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004344 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 760011004345 nucleotide binding site/active site [active] 760011004346 HIT family signature motif; other site 760011004347 catalytic residue [active] 760011004348 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 760011004349 catalytic triad [active] 760011004350 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 760011004351 tRNA synthetase B5 domain; Region: B5; pfam03484 760011004352 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 760011004353 dimer interface [polypeptide binding]; other site 760011004354 motif 1; other site 760011004355 motif 3; other site 760011004356 motif 2; other site 760011004357 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 760011004358 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 760011004359 dimer interface [polypeptide binding]; other site 760011004360 motif 1; other site 760011004361 active site 760011004362 motif 2; other site 760011004363 motif 3; other site 760011004364 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011004365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011004366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011004367 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 760011004368 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760011004369 tetramer interface [polypeptide binding]; other site 760011004370 TPP-binding site [chemical binding]; other site 760011004371 heterodimer interface [polypeptide binding]; other site 760011004372 phosphorylation loop region [posttranslational modification] 760011004373 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760011004374 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 760011004375 alpha subunit interface [polypeptide binding]; other site 760011004376 TPP binding site [chemical binding]; other site 760011004377 heterodimer interface [polypeptide binding]; other site 760011004378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760011004379 Flavin Reductases; Region: FlaRed; cl00801 760011004380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011004381 active site 760011004382 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 760011004383 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 760011004384 active site 760011004385 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 760011004386 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 760011004387 GDP-binding site [chemical binding]; other site 760011004388 ACT binding site; other site 760011004389 IMP binding site; other site 760011004390 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 760011004391 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011004392 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004393 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004394 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004395 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004396 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004397 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004398 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004399 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004400 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004401 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004402 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004403 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004404 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 760011004405 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 760011004406 tetramer interface [polypeptide binding]; other site 760011004407 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 760011004408 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 760011004409 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 760011004410 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 760011004411 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 760011004412 dimer interface [polypeptide binding]; other site 760011004413 ADP-ribose binding site [chemical binding]; other site 760011004414 active site 760011004415 nudix motif; other site 760011004416 metal binding site [ion binding]; metal-binding site 760011004417 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 760011004418 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 760011004419 Walker A motif; other site 760011004420 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 760011004421 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 760011004422 active site 760011004423 catalytic residues [active] 760011004424 metal binding site [ion binding]; metal-binding site 760011004425 homodimer binding site [polypeptide binding]; other site 760011004426 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 760011004427 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760011004428 carboxyltransferase (CT) interaction site; other site 760011004429 biotinylation site [posttranslational modification]; other site 760011004430 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760011004431 carboxyltransferase (CT) interaction site; other site 760011004432 biotinylation site [posttranslational modification]; other site 760011004433 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 760011004434 catalytic motif [active] 760011004435 Zn binding site [ion binding]; other site 760011004436 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 760011004437 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 760011004438 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 760011004439 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 760011004440 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 760011004441 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 760011004442 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 760011004443 active site 760011004444 catalytic site [active] 760011004445 substrate binding site [chemical binding]; other site 760011004446 HRDC domain; Region: HRDC; cl02578 760011004447 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 760011004448 active site 760011004449 substrate-binding site [chemical binding]; other site 760011004450 metal-binding site [ion binding] 760011004451 GTP binding site [chemical binding]; other site 760011004452 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 760011004453 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 760011004454 ligand binding site [chemical binding]; other site 760011004455 flexible hinge region; other site 760011004456 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 760011004457 Peptidase family U32; Region: Peptidase_U32; pfam01136 760011004458 Collagenase; Region: DUF3656; pfam12392 760011004459 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 760011004460 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 760011004461 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 760011004462 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760011004463 GMP synthase; Reviewed; Region: guaA; PRK00074 760011004464 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 760011004465 AMP/PPi binding site [chemical binding]; other site 760011004466 candidate oxyanion hole; other site 760011004467 catalytic triad [active] 760011004468 potential glutamine specificity residues [chemical binding]; other site 760011004469 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 760011004470 ATP Binding subdomain [chemical binding]; other site 760011004471 Ligand Binding sites [chemical binding]; other site 760011004472 Dimerization subdomain; other site 760011004473 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 760011004474 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 760011004475 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 760011004476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011004477 Walker A/P-loop; other site 760011004478 ATP binding site [chemical binding]; other site 760011004479 Q-loop/lid; other site 760011004480 ABC transporter signature motif; other site 760011004481 Walker B; other site 760011004482 D-loop; other site 760011004483 H-loop/switch region; other site 760011004484 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760011004485 Walker A/P-loop; other site 760011004486 ATP binding site [chemical binding]; other site 760011004487 Q-loop/lid; other site 760011004488 ABC transporter signature motif; other site 760011004489 Walker B; other site 760011004490 D-loop; other site 760011004491 H-loop/switch region; other site 760011004492 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760011004493 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 760011004494 putative acyl-acceptor binding pocket; other site 760011004495 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011004496 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011004497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011004498 Walker A/P-loop; other site 760011004499 ATP binding site [chemical binding]; other site 760011004500 Q-loop/lid; other site 760011004501 ABC transporter signature motif; other site 760011004502 Walker B; other site 760011004503 D-loop; other site 760011004504 H-loop/switch region; other site 760011004505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 760011004506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 760011004507 ATP binding site [chemical binding]; other site 760011004508 putative Mg++ binding site [ion binding]; other site 760011004509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011004510 nucleotide binding region [chemical binding]; other site 760011004511 ATP-binding site [chemical binding]; other site 760011004512 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 760011004513 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 760011004514 homodimer interface [polypeptide binding]; other site 760011004515 substrate-cofactor binding pocket; other site 760011004516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011004517 catalytic residue [active] 760011004518 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 760011004519 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 760011004520 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 760011004521 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 760011004522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011004523 S-adenosylmethionine binding site [chemical binding]; other site 760011004524 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 760011004525 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 760011004526 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 760011004527 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 760011004528 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 760011004529 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 760011004530 trmE is a tRNA modification GTPase; Region: trmE; cd04164 760011004531 G1 box; other site 760011004532 GTP/Mg2+ binding site [chemical binding]; other site 760011004533 Switch I region; other site 760011004534 G2 box; other site 760011004535 Switch II region; other site 760011004536 G3 box; other site 760011004537 G4 box; other site 760011004538 G5 box; other site 760011004539 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 760011004540 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 760011004541 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 760011004542 motif 1; other site 760011004543 dimer interface [polypeptide binding]; other site 760011004544 active site 760011004545 motif 2; other site 760011004546 motif 3; other site 760011004547 elongation factor P; Validated; Region: PRK00529 760011004548 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 760011004549 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 760011004550 RNA binding site [nucleotide binding]; other site 760011004551 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 760011004552 RNA binding site [nucleotide binding]; other site 760011004553 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011004554 Radical SAM superfamily; Region: Radical_SAM; pfam04055 760011004555 FeS/SAM binding site; other site 760011004556 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 760011004557 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011004558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011004559 YhhN-like protein; Region: YhhN; pfam07947 760011004560 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004561 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004562 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 760011004563 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 760011004564 CoA-binding site [chemical binding]; other site 760011004565 ATP-binding [chemical binding]; other site 760011004566 DNA polymerase I; Provisional; Region: PRK05755 760011004567 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 760011004568 active site 760011004569 metal binding site 1 [ion binding]; metal-binding site 760011004570 putative 5' ssDNA interaction site; other site 760011004571 metal binding site 3; metal-binding site 760011004572 metal binding site 2 [ion binding]; metal-binding site 760011004573 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 760011004574 putative DNA binding site [nucleotide binding]; other site 760011004575 putative metal binding site [ion binding]; other site 760011004576 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 760011004577 active site 760011004578 catalytic site [active] 760011004579 substrate binding site [chemical binding]; other site 760011004580 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 760011004581 active site 760011004582 DNA binding site [nucleotide binding] 760011004583 catalytic site [active] 760011004584 putative hydrolase; Provisional; Region: PRK02113 760011004585 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 760011004586 Fijivirus P9-2 protein; Region: Fijivirus_P9-2; pfam06837 760011004587 NAD synthetase; Reviewed; Region: nadE; PRK02628 760011004588 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 760011004589 multimer interface [polypeptide binding]; other site 760011004590 active site 760011004591 catalytic triad [active] 760011004592 protein interface 1 [polypeptide binding]; other site 760011004593 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 760011004594 homodimer interface [polypeptide binding]; other site 760011004595 NAD binding pocket [chemical binding]; other site 760011004596 ATP binding pocket [chemical binding]; other site 760011004597 Mg binding site [ion binding]; other site 760011004598 active-site loop [active] 760011004599 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 760011004600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011004601 S-adenosylmethionine binding site [chemical binding]; other site 760011004602 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 760011004603 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 760011004604 Zn binding site [ion binding]; other site 760011004605 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 760011004606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011004607 active site 760011004608 phosphorylation site [posttranslational modification] 760011004609 intermolecular recognition site; other site 760011004610 dimerization interface [polypeptide binding]; other site 760011004611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011004612 Walker A motif; other site 760011004613 ATP binding site [chemical binding]; other site 760011004614 Walker B motif; other site 760011004615 arginine finger; other site 760011004616 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 760011004617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760011004618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 760011004619 dimer interface [polypeptide binding]; other site 760011004620 phosphorylation site [posttranslational modification] 760011004621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011004622 ATP binding site [chemical binding]; other site 760011004623 Mg2+ binding site [ion binding]; other site 760011004624 G-X-G motif; other site 760011004625 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 760011004626 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 760011004627 FtsX-like permease family; Region: FtsX; pfam02687 760011004628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 760011004629 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 760011004630 Walker A/P-loop; other site 760011004631 ATP binding site [chemical binding]; other site 760011004632 Q-loop/lid; other site 760011004633 ABC transporter signature motif; other site 760011004634 Walker B; other site 760011004635 D-loop; other site 760011004636 H-loop/switch region; other site 760011004637 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 760011004638 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 760011004639 HlyD family secretion protein; Region: HlyD_3; pfam13437 760011004640 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 760011004641 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 760011004642 dimerization interface [polypeptide binding]; other site 760011004643 domain crossover interface; other site 760011004644 redox-dependent activation switch; other site 760011004645 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 760011004646 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 760011004647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 760011004648 Methyltransferase domain; Region: Methyltransf_26; pfam13659 760011004649 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 760011004650 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 760011004651 Fic/DOC family; Region: Fic; cl00960 760011004652 MarR family; Region: MarR_2; cl17246 760011004653 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011004654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760011004655 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 760011004656 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011004657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004658 dimer interface [polypeptide binding]; other site 760011004659 conserved gate region; other site 760011004660 putative PBP binding loops; other site 760011004661 ABC-ATPase subunit interface; other site 760011004662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004663 dimer interface [polypeptide binding]; other site 760011004664 conserved gate region; other site 760011004665 putative PBP binding loops; other site 760011004666 ABC-ATPase subunit interface; other site 760011004667 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011004668 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 760011004669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 760011004670 YheO-like PAS domain; Region: PAS_6; pfam08348 760011004671 HTH domain; Region: HTH_22; pfam13309 760011004672 hypothetical protein; Provisional; Region: PRK02947 760011004673 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 760011004674 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 760011004675 MarR family; Region: MarR_2; cl17246 760011004676 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 760011004677 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 760011004678 active site 760011004679 HIGH motif; other site 760011004680 dimer interface [polypeptide binding]; other site 760011004681 KMSKS motif; other site 760011004682 magnesium-transporting ATPase; Provisional; Region: PRK15122 760011004683 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 760011004684 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760011004685 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760011004686 Soluble P-type ATPase [General function prediction only]; Region: COG4087 760011004687 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760011004688 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 760011004689 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 760011004690 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 760011004691 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 760011004692 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760011004693 homodimer interface [polypeptide binding]; other site 760011004694 substrate-cofactor binding pocket; other site 760011004695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011004696 catalytic residue [active] 760011004697 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 760011004698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011004699 active site 760011004700 phosphorylation site [posttranslational modification] 760011004701 intermolecular recognition site; other site 760011004702 dimerization interface [polypeptide binding]; other site 760011004703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004704 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760011004705 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760011004706 dimerization interface [polypeptide binding]; other site 760011004707 Histidine kinase; Region: His_kinase; pfam06580 760011004708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011004709 ATP binding site [chemical binding]; other site 760011004710 Mg2+ binding site [ion binding]; other site 760011004711 G-X-G motif; other site 760011004712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011004713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011004714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004715 conserved gate region; other site 760011004716 dimer interface [polypeptide binding]; other site 760011004717 putative PBP binding loops; other site 760011004718 ABC-ATPase subunit interface; other site 760011004719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011004720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004721 dimer interface [polypeptide binding]; other site 760011004722 conserved gate region; other site 760011004723 putative PBP binding loops; other site 760011004724 ABC-ATPase subunit interface; other site 760011004725 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760011004726 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 760011004727 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 760011004728 NADP binding site [chemical binding]; other site 760011004729 homodimer interface [polypeptide binding]; other site 760011004730 active site 760011004731 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004732 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004733 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004734 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004735 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004736 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004737 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004738 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004739 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004740 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004741 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011004742 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004743 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004744 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004745 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004746 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004747 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004748 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004749 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004750 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004751 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 760011004753 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 760011004754 Uncharacterized conserved protein [Function unknown]; Region: COG1912 760011004755 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 760011004756 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 760011004757 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 760011004758 active site 760011004759 metal binding site [ion binding]; metal-binding site 760011004760 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 760011004761 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760011004762 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760011004763 Walker A/P-loop; other site 760011004764 ATP binding site [chemical binding]; other site 760011004765 Q-loop/lid; other site 760011004766 ABC transporter signature motif; other site 760011004767 Walker B; other site 760011004768 D-loop; other site 760011004769 H-loop/switch region; other site 760011004770 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 760011004771 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 760011004772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 760011004773 Walker A/P-loop; other site 760011004774 ATP binding site [chemical binding]; other site 760011004775 Q-loop/lid; other site 760011004776 ABC transporter signature motif; other site 760011004777 Walker B; other site 760011004778 D-loop; other site 760011004779 H-loop/switch region; other site 760011004780 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 760011004781 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011004782 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004783 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004784 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004785 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004786 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004787 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004788 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004789 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004790 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004791 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004792 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004793 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004794 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004795 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011004796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011004797 TM-ABC transporter signature motif; other site 760011004798 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011004799 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011004800 Walker A/P-loop; other site 760011004801 ATP binding site [chemical binding]; other site 760011004802 Q-loop/lid; other site 760011004803 ABC transporter signature motif; other site 760011004804 Walker B; other site 760011004805 D-loop; other site 760011004806 H-loop/switch region; other site 760011004807 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011004808 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011004809 Response regulator receiver domain; Region: Response_reg; pfam00072 760011004810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011004811 active site 760011004812 phosphorylation site [posttranslational modification] 760011004813 intermolecular recognition site; other site 760011004814 dimerization interface [polypeptide binding]; other site 760011004815 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011004816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011004817 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760011004818 Cache domain; Region: Cache_1; pfam02743 760011004819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760011004820 dimerization interface [polypeptide binding]; other site 760011004821 Histidine kinase; Region: His_kinase; pfam06580 760011004822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011004823 ATP binding site [chemical binding]; other site 760011004824 Mg2+ binding site [ion binding]; other site 760011004825 G-X-G motif; other site 760011004826 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011004827 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011004828 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 760011004829 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 760011004830 ligand binding site [chemical binding]; other site 760011004831 calcium binding site [ion binding]; other site 760011004832 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011004833 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011004834 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004835 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004836 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004837 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004838 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004839 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004840 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004841 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004842 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004843 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011004844 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011004845 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 760011004846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004847 dimer interface [polypeptide binding]; other site 760011004848 conserved gate region; other site 760011004849 putative PBP binding loops; other site 760011004850 ABC-ATPase subunit interface; other site 760011004851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004852 dimer interface [polypeptide binding]; other site 760011004853 conserved gate region; other site 760011004854 putative PBP binding loops; other site 760011004855 ABC-ATPase subunit interface; other site 760011004856 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 760011004857 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 760011004858 substrate binding pocket [chemical binding]; other site 760011004859 membrane-bound complex binding site; other site 760011004860 hinge residues; other site 760011004861 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 760011004862 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 760011004863 Walker A/P-loop; other site 760011004864 ATP binding site [chemical binding]; other site 760011004865 Q-loop/lid; other site 760011004866 ABC transporter signature motif; other site 760011004867 Walker B; other site 760011004868 D-loop; other site 760011004869 H-loop/switch region; other site 760011004870 S-ribosylhomocysteinase; Provisional; Region: PRK02260 760011004871 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 760011004872 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 760011004873 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 760011004874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004875 dimer interface [polypeptide binding]; other site 760011004876 conserved gate region; other site 760011004877 putative PBP binding loops; other site 760011004878 ABC-ATPase subunit interface; other site 760011004879 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011004880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011004881 dimer interface [polypeptide binding]; other site 760011004882 conserved gate region; other site 760011004883 putative PBP binding loops; other site 760011004884 ABC-ATPase subunit interface; other site 760011004885 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011004886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011004887 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760011004888 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 760011004889 AP (apurinic/apyrimidinic) site pocket; other site 760011004890 DNA interaction; other site 760011004891 Metal-binding active site; metal-binding site 760011004892 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 760011004893 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 760011004894 DNA binding residues [nucleotide binding] 760011004895 dimer interface [polypeptide binding]; other site 760011004896 hypothetical protein; Reviewed; Region: PRK00024 760011004897 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 760011004898 MPN+ (JAMM) motif; other site 760011004899 Zinc-binding site [ion binding]; other site 760011004900 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 760011004901 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 760011004902 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 760011004903 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 760011004904 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 760011004905 metal binding site [ion binding]; metal-binding site 760011004906 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 760011004907 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 760011004908 substrate binding site [chemical binding]; other site 760011004909 glutamase interaction surface [polypeptide binding]; other site 760011004910 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 760011004911 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 760011004912 catalytic residues [active] 760011004913 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 760011004914 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 760011004915 putative active site [active] 760011004916 oxyanion strand; other site 760011004917 catalytic triad [active] 760011004918 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 760011004919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011004920 active site 760011004921 motif I; other site 760011004922 motif II; other site 760011004923 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 760011004924 putative active site pocket [active] 760011004925 4-fold oligomerization interface [polypeptide binding]; other site 760011004926 metal binding residues [ion binding]; metal-binding site 760011004927 3-fold/trimer interface [polypeptide binding]; other site 760011004928 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 760011004929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011004930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011004931 homodimer interface [polypeptide binding]; other site 760011004932 catalytic residue [active] 760011004933 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 760011004934 histidinol dehydrogenase; Region: hisD; TIGR00069 760011004935 NAD binding site [chemical binding]; other site 760011004936 dimerization interface [polypeptide binding]; other site 760011004937 product binding site; other site 760011004938 substrate binding site [chemical binding]; other site 760011004939 zinc binding site [ion binding]; other site 760011004940 catalytic residues [active] 760011004941 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 760011004942 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 760011004943 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 760011004944 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 760011004945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011004946 motif II; other site 760011004947 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 760011004948 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760011004949 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 760011004950 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 760011004951 hinge; other site 760011004952 active site 760011004953 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 760011004954 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 760011004955 tetramer interface [polypeptide binding]; other site 760011004956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011004957 catalytic residue [active] 760011004958 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 760011004959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011004960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011004961 homodimer interface [polypeptide binding]; other site 760011004962 catalytic residue [active] 760011004963 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 760011004964 Part of AAA domain; Region: AAA_19; pfam13245 760011004965 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 760011004966 Family description; Region: UvrD_C_2; pfam13538 760011004967 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760011004968 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 760011004969 CAAX protease self-immunity; Region: Abi; pfam02517 760011004970 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 760011004971 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 760011004972 active site 760011004973 substrate binding site [chemical binding]; other site 760011004974 Mg2+ binding site [ion binding]; other site 760011004975 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 760011004976 active site 760011004977 NAD binding site [chemical binding]; other site 760011004978 metal binding site [ion binding]; metal-binding site 760011004979 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 760011004980 crystallin beta/gamma motif-containing protein; Region: PHA00657 760011004981 crystallin beta/gamma motif-containing protein; Region: PHA00657 760011004982 MAEBL; Provisional; Region: PTZ00121 760011004983 Fumarase C-terminus; Region: Fumerase_C; cl00795 760011004984 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 760011004985 VanZ like family; Region: VanZ; cl01971 760011004986 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 760011004987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011004988 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 760011004989 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 760011004990 active site 760011004991 nucleophile elbow; other site 760011004992 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 760011004993 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 760011004994 putative active site [active] 760011004995 substrate binding site [chemical binding]; other site 760011004996 putative cosubstrate binding site; other site 760011004997 catalytic site [active] 760011004998 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 760011004999 substrate binding site [chemical binding]; other site 760011005000 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 760011005001 active site 760011005002 catalytic residues [active] 760011005003 metal binding site [ion binding]; metal-binding site 760011005004 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005005 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005006 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 760011005007 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005008 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005009 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005010 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005011 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005012 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005013 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005014 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005015 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005016 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005017 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005018 primosome assembly protein PriA; Validated; Region: PRK05580 760011005019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011005020 ATP binding site [chemical binding]; other site 760011005021 putative Mg++ binding site [ion binding]; other site 760011005022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011005023 ATP-binding site [chemical binding]; other site 760011005024 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 760011005025 Fe-S cluster binding site [ion binding]; other site 760011005026 active site 760011005027 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 760011005028 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 760011005029 dimerization interface 3.5A [polypeptide binding]; other site 760011005030 active site 760011005031 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 760011005032 YbbR-like protein; Region: YbbR; pfam07949 760011005033 Uncharacterized conserved protein [Function unknown]; Region: COG1624 760011005034 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 760011005035 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 760011005036 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 760011005037 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 760011005038 Peptidase M16C associated; Region: M16C_assoc; pfam08367 760011005039 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 760011005040 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 760011005041 active site 760011005042 catalytic site [active] 760011005043 peptidase T; Region: peptidase-T; TIGR01882 760011005044 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 760011005045 metal binding site [ion binding]; metal-binding site 760011005046 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011005047 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005048 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005051 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005057 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005058 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005060 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 760011005061 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 760011005062 CoA binding domain; Region: CoA_binding; pfam02629 760011005063 Homoserine O-succinyltransferase; Region: HTS; pfam04204 760011005064 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 760011005065 proposed active site lysine [active] 760011005066 conserved cys residue [active] 760011005067 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 760011005068 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 760011005069 homodimer interface [polypeptide binding]; other site 760011005070 substrate-cofactor binding pocket; other site 760011005071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011005072 catalytic residue [active] 760011005073 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 760011005074 putative catalytic site [active] 760011005075 putative metal binding site [ion binding]; other site 760011005076 putative phosphate binding site [ion binding]; other site 760011005077 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011005078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011005079 putative substrate translocation pore; other site 760011005080 HEAT repeats; Region: HEAT_2; pfam13646 760011005081 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 760011005082 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 760011005083 oligomer interface [polypeptide binding]; other site 760011005084 active site residues [active] 760011005085 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 760011005086 MgtC family; Region: MgtC; pfam02308 760011005087 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 760011005088 GTPase Era; Reviewed; Region: era; PRK00089 760011005089 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 760011005090 G1 box; other site 760011005091 GTP/Mg2+ binding site [chemical binding]; other site 760011005092 Switch I region; other site 760011005093 G2 box; other site 760011005094 Switch II region; other site 760011005095 G3 box; other site 760011005096 G4 box; other site 760011005097 G5 box; other site 760011005098 KH domain; Region: KH_2; pfam07650 760011005099 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011005100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760011005101 nucleotide binding site [chemical binding]; other site 760011005102 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 760011005103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 760011005104 active site 760011005105 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011005106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005107 dimer interface [polypeptide binding]; other site 760011005108 conserved gate region; other site 760011005109 putative PBP binding loops; other site 760011005110 ABC-ATPase subunit interface; other site 760011005111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005112 dimer interface [polypeptide binding]; other site 760011005113 conserved gate region; other site 760011005114 putative PBP binding loops; other site 760011005115 ABC-ATPase subunit interface; other site 760011005116 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011005117 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 760011005118 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 760011005119 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 760011005120 active site 760011005121 substrate binding site [chemical binding]; other site 760011005122 metal binding site [ion binding]; metal-binding site 760011005123 Lysyl-tRNA synthetase (class I) [Translation, ribosomal structure and biogenesis]; Region: LysS; COG1384 760011005124 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011005125 active site 760011005126 nucleotide binding site [chemical binding]; other site 760011005127 HIGH motif; other site 760011005128 KMSKS motif; other site 760011005129 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 760011005130 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 760011005131 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 760011005132 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760011005133 HIGH motif; other site 760011005134 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 760011005135 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 760011005136 active site 760011005137 KMSKS motif; other site 760011005138 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 760011005139 tRNA binding surface [nucleotide binding]; other site 760011005140 anticodon binding site; other site 760011005141 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 760011005142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011005143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011005144 putative substrate translocation pore; other site 760011005145 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 760011005146 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 760011005147 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 760011005148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011005149 Walker A/P-loop; other site 760011005150 ATP binding site [chemical binding]; other site 760011005151 Q-loop/lid; other site 760011005152 ABC transporter signature motif; other site 760011005153 Walker B; other site 760011005154 D-loop; other site 760011005155 H-loop/switch region; other site 760011005156 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 760011005157 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 760011005158 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 760011005159 Part of AAA domain; Region: AAA_19; pfam13245 760011005160 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 760011005161 AAA domain; Region: AAA_12; pfam13087 760011005162 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 760011005163 Fic family protein [Function unknown]; Region: COG3177 760011005164 Fic/DOC family; Region: Fic; pfam02661 760011005165 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 760011005166 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 760011005167 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 760011005168 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 760011005169 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 760011005170 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 760011005171 ligand binding site [chemical binding]; other site 760011005172 homodimer interface [polypeptide binding]; other site 760011005173 NAD(P) binding site [chemical binding]; other site 760011005174 trimer interface B [polypeptide binding]; other site 760011005175 trimer interface A [polypeptide binding]; other site 760011005176 FAD binding domain; Region: FAD_binding_4; pfam01565 760011005177 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 760011005178 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 760011005179 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 760011005180 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 760011005181 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 760011005182 Ligand binding site [chemical binding]; other site 760011005183 Electron transfer flavoprotein domain; Region: ETF; pfam01012 760011005184 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 760011005185 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 760011005186 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760011005187 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760011005188 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 760011005189 dimerization domain swap beta strand [polypeptide binding]; other site 760011005190 regulatory protein interface [polypeptide binding]; other site 760011005191 active site 760011005192 regulatory phosphorylation site [posttranslational modification]; other site 760011005193 putative mutase; Provisional; Region: PRK12383 760011005194 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 760011005195 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 760011005196 dimer interface [polypeptide binding]; other site 760011005197 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 760011005198 active site 760011005199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 760011005200 substrate binding site [chemical binding]; other site 760011005201 catalytic residue [active] 760011005202 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 760011005203 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011005204 catalytic residue [active] 760011005205 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 760011005206 active site 760011005207 substrate binding pocket [chemical binding]; other site 760011005208 homodimer interaction site [polypeptide binding]; other site 760011005209 Protein of unknown function; Region: YhfT; pfam10797 760011005210 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 760011005211 PRD domain; Region: PRD; pfam00874 760011005212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011005213 DNA-binding site [nucleotide binding]; DNA binding site 760011005214 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 760011005215 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 760011005216 dimer interface [polypeptide binding]; other site 760011005217 active site 760011005218 metal binding site [ion binding]; metal-binding site 760011005219 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011005220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011005221 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760011005222 Walker A/P-loop; other site 760011005223 ATP binding site [chemical binding]; other site 760011005224 Q-loop/lid; other site 760011005225 ABC transporter signature motif; other site 760011005226 Walker B; other site 760011005227 D-loop; other site 760011005228 H-loop/switch region; other site 760011005229 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011005230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011005231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011005232 Walker A/P-loop; other site 760011005233 ATP binding site [chemical binding]; other site 760011005234 Q-loop/lid; other site 760011005235 ABC transporter signature motif; other site 760011005236 Walker B; other site 760011005237 D-loop; other site 760011005238 H-loop/switch region; other site 760011005239 MarR family; Region: MarR_2; pfam12802 760011005240 Transcriptional regulators [Transcription]; Region: MarR; COG1846 760011005241 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011005242 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005243 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005246 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005248 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005249 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005250 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005251 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011005252 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005253 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005254 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005255 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005256 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005257 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005258 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005259 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005260 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005261 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005262 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005263 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011005264 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005265 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005266 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 760011005267 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 760011005268 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005269 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005270 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005271 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005272 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005273 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005274 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005275 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005276 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005277 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005278 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 760011005279 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 760011005280 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760011005281 hypothetical protein; Provisional; Region: PRK10621 760011005282 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760011005283 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 760011005284 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011005285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011005286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005287 dimer interface [polypeptide binding]; other site 760011005288 conserved gate region; other site 760011005289 ABC-ATPase subunit interface; other site 760011005290 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011005291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005292 dimer interface [polypeptide binding]; other site 760011005293 conserved gate region; other site 760011005294 ABC-ATPase subunit interface; other site 760011005295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011005296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011005297 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 760011005298 Walker A/P-loop; other site 760011005299 ATP binding site [chemical binding]; other site 760011005300 Q-loop/lid; other site 760011005301 ABC transporter signature motif; other site 760011005302 Walker B; other site 760011005303 D-loop; other site 760011005304 H-loop/switch region; other site 760011005305 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 760011005306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 760011005307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011005308 Walker A/P-loop; other site 760011005309 ATP binding site [chemical binding]; other site 760011005310 Q-loop/lid; other site 760011005311 ABC transporter signature motif; other site 760011005312 Walker B; other site 760011005313 D-loop; other site 760011005314 H-loop/switch region; other site 760011005315 beta-phosphoglucomutase; Region: bPGM; TIGR01990 760011005316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011005317 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 760011005318 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 760011005319 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 760011005320 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011005321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005322 dimer interface [polypeptide binding]; other site 760011005323 conserved gate region; other site 760011005324 putative PBP binding loops; other site 760011005325 ABC-ATPase subunit interface; other site 760011005326 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 760011005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011005328 dimer interface [polypeptide binding]; other site 760011005329 conserved gate region; other site 760011005330 ABC-ATPase subunit interface; other site 760011005331 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 760011005332 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011005333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011005334 DNA binding site [nucleotide binding] 760011005335 domain linker motif; other site 760011005336 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011005337 dimerization interface [polypeptide binding]; other site 760011005338 ligand binding site [chemical binding]; other site 760011005339 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 760011005340 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 760011005341 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 760011005342 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005343 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005344 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760011005345 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 760011005346 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 760011005347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011005348 FeS/SAM binding site; other site 760011005349 Pyruvate formate lyase 1; Region: PFL1; cd01678 760011005350 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 760011005351 coenzyme A binding site [chemical binding]; other site 760011005352 active site 760011005353 catalytic residues [active] 760011005354 glycine loop; other site 760011005355 asparagine synthetase AsnA; Provisional; Region: PRK05425 760011005356 motif 1; other site 760011005357 dimer interface [polypeptide binding]; other site 760011005358 active site 760011005359 motif 2; other site 760011005360 motif 3; other site 760011005361 flavoprotein, HI0933 family; Region: TIGR00275 760011005362 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 760011005363 Predicted flavoprotein [General function prediction only]; Region: COG0431 760011005364 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005365 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005366 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 760011005367 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760011005368 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 760011005369 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760011005370 glycerol kinase; Provisional; Region: glpK; PRK00047 760011005371 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 760011005372 N- and C-terminal domain interface [polypeptide binding]; other site 760011005373 active site 760011005374 MgATP binding site [chemical binding]; other site 760011005375 catalytic site [active] 760011005376 metal binding site [ion binding]; metal-binding site 760011005377 glycerol binding site [chemical binding]; other site 760011005378 homotetramer interface [polypeptide binding]; other site 760011005379 homodimer interface [polypeptide binding]; other site 760011005380 FBP binding site [chemical binding]; other site 760011005381 protein IIAGlc interface [polypeptide binding]; other site 760011005382 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 760011005383 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 760011005384 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 760011005385 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 760011005386 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 760011005387 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 760011005388 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 760011005389 dimer interface [polypeptide binding]; other site 760011005390 active site 760011005391 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 760011005392 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 760011005393 NAD(P) binding site [chemical binding]; other site 760011005394 homotetramer interface [polypeptide binding]; other site 760011005395 homodimer interface [polypeptide binding]; other site 760011005396 active site 760011005397 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 760011005398 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 760011005399 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 760011005400 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 760011005401 carboxyltransferase (CT) interaction site; other site 760011005402 biotinylation site [posttranslational modification]; other site 760011005403 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 760011005404 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760011005405 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011005406 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 760011005407 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 760011005408 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 760011005409 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 760011005410 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 760011005411 acyl-activating enzyme (AAE) consensus motif; other site 760011005412 AMP binding site [chemical binding]; other site 760011005413 active site 760011005414 CoA binding site [chemical binding]; other site 760011005415 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 760011005416 active site 1 [active] 760011005417 active site 2 [active] 760011005418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011005419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 760011005420 putative substrate translocation pore; other site 760011005421 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 760011005422 dimer interface [polypeptide binding]; other site 760011005423 catalytic triad [active] 760011005424 peroxidatic and resolving cysteines [active] 760011005425 Cupin domain; Region: Cupin_2; pfam07883 760011005426 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 760011005427 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 760011005428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760011005429 NAD(P) binding site [chemical binding]; other site 760011005430 active site 760011005431 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 760011005432 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 760011005433 active site 760011005434 FMN binding site [chemical binding]; other site 760011005435 substrate binding site [chemical binding]; other site 760011005436 putative catalytic residue [active] 760011005437 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011005438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011005439 DNA binding site [nucleotide binding] 760011005440 domain linker motif; other site 760011005441 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011005442 dimerization interface [polypeptide binding]; other site 760011005443 ligand binding site [chemical binding]; other site 760011005444 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 760011005445 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 760011005446 Walker A/P-loop; other site 760011005447 ATP binding site [chemical binding]; other site 760011005448 Q-loop/lid; other site 760011005449 ABC transporter signature motif; other site 760011005450 Walker B; other site 760011005451 D-loop; other site 760011005452 H-loop/switch region; other site 760011005453 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 760011005454 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 760011005455 Walker A/P-loop; other site 760011005456 ATP binding site [chemical binding]; other site 760011005457 Q-loop/lid; other site 760011005458 ABC transporter signature motif; other site 760011005459 Walker B; other site 760011005460 D-loop; other site 760011005461 H-loop/switch region; other site 760011005462 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 760011005463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005464 TM-ABC transporter signature motif; other site 760011005465 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005466 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 760011005467 TM-ABC transporter signature motif; other site 760011005468 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 760011005469 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011005470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 760011005471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 760011005472 active site 760011005473 catalytic tetrad [active] 760011005474 YmdB-like protein; Region: YmdB; pfam13277 760011005475 active site 760011005476 metal binding site [ion binding]; metal-binding site 760011005477 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 760011005478 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 760011005479 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 760011005480 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 760011005481 Walker A/P-loop; other site 760011005482 ATP binding site [chemical binding]; other site 760011005483 Q-loop/lid; other site 760011005484 ABC transporter signature motif; other site 760011005485 Walker B; other site 760011005486 D-loop; other site 760011005487 H-loop/switch region; other site 760011005488 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 760011005489 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 760011005490 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 760011005491 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 760011005492 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 760011005493 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 760011005494 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 760011005495 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 760011005496 Hpr binding site; other site 760011005497 active site 760011005498 homohexamer subunit interaction site [polypeptide binding]; other site 760011005499 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 760011005500 dimerization domain swap beta strand [polypeptide binding]; other site 760011005501 regulatory protein interface [polypeptide binding]; other site 760011005502 active site 760011005503 regulatory phosphorylation site [posttranslational modification]; other site 760011005504 LexA repressor; Validated; Region: PRK00215 760011005505 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 760011005506 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 760011005507 Catalytic site [active] 760011005508 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 760011005509 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 760011005510 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 760011005511 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 760011005512 GIY-YIG motif/motif A; other site 760011005513 active site 760011005514 catalytic site [active] 760011005515 putative DNA binding site [nucleotide binding]; other site 760011005516 metal binding site [ion binding]; metal-binding site 760011005517 UvrB/uvrC motif; Region: UVR; pfam02151 760011005518 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 760011005519 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 760011005520 RNA methyltransferase, RsmE family; Region: TIGR00046 760011005521 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 760011005522 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 760011005523 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 760011005524 peptide binding site [polypeptide binding]; other site 760011005525 4-alpha-glucanotransferase; Provisional; Region: PRK14508 760011005526 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 760011005527 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 760011005528 substrate binding site; other site 760011005529 dimer interface; other site 760011005530 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 760011005531 homotrimer interaction site [polypeptide binding]; other site 760011005532 zinc binding site [ion binding]; other site 760011005533 CDP-binding sites; other site 760011005534 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 760011005535 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 760011005536 elongation factor G; Reviewed; Region: PRK12740 760011005537 G1 box; other site 760011005538 putative GEF interaction site [polypeptide binding]; other site 760011005539 GTP/Mg2+ binding site [chemical binding]; other site 760011005540 Switch I region; other site 760011005541 G2 box; other site 760011005542 G3 box; other site 760011005543 Switch II region; other site 760011005544 G4 box; other site 760011005545 G5 box; other site 760011005546 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 760011005547 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 760011005548 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 760011005549 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 760011005550 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760011005551 active site 2 [active] 760011005552 active site 1 [active] 760011005553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760011005554 active site 2 [active] 760011005555 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 760011005556 putative active site [active] 760011005557 catalytic residue [active] 760011005558 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005559 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005560 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005561 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005562 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005563 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005564 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005565 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005566 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005567 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005568 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011005570 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011005571 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 760011005572 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 760011005573 Walker A/P-loop; other site 760011005574 ATP binding site [chemical binding]; other site 760011005575 Q-loop/lid; other site 760011005576 ABC transporter signature motif; other site 760011005577 Walker B; other site 760011005578 D-loop; other site 760011005579 H-loop/switch region; other site 760011005580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 760011005581 DNA-binding site [nucleotide binding]; DNA binding site 760011005582 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 760011005583 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 760011005584 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 760011005585 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 760011005586 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 760011005587 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 760011005588 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760011005589 tetramer interface [polypeptide binding]; other site 760011005590 catalytic Zn binding site [ion binding]; other site 760011005591 NADP binding site [chemical binding]; other site 760011005592 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 760011005593 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 760011005594 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 760011005595 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 760011005596 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 760011005597 homodimer interface [polypeptide binding]; other site 760011005598 substrate-cofactor binding pocket; other site 760011005599 catalytic residue [active] 760011005600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760011005601 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760011005602 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 760011005603 threonine dehydratase; Provisional; Region: PRK08198 760011005604 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 760011005605 tetramer interface [polypeptide binding]; other site 760011005606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011005607 catalytic residue [active] 760011005608 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 760011005609 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011005610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 760011005611 nucleotide binding site [chemical binding]; other site 760011005612 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 760011005613 dimer interface [polypeptide binding]; other site 760011005614 active site 760011005615 Response regulator receiver domain; Region: Response_reg; pfam00072 760011005616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011005617 active site 760011005618 phosphorylation site [posttranslational modification] 760011005619 intermolecular recognition site; other site 760011005620 dimerization interface [polypeptide binding]; other site 760011005621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011005622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011005623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011005624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 760011005625 Histidine kinase; Region: His_kinase; pfam06580 760011005626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011005627 ATP binding site [chemical binding]; other site 760011005628 Mg2+ binding site [ion binding]; other site 760011005629 G-X-G motif; other site 760011005630 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011005631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011005632 Walker A/P-loop; other site 760011005633 ATP binding site [chemical binding]; other site 760011005634 Q-loop/lid; other site 760011005635 ABC transporter signature motif; other site 760011005636 Walker B; other site 760011005637 H-loop/switch region; other site 760011005638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011005639 Walker A/P-loop; other site 760011005640 ATP binding site [chemical binding]; other site 760011005641 Q-loop/lid; other site 760011005642 Walker B; other site 760011005643 D-loop; other site 760011005644 H-loop/switch region; other site 760011005645 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011005646 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011005647 Walker A/P-loop; other site 760011005648 ATP binding site [chemical binding]; other site 760011005649 Q-loop/lid; other site 760011005650 ABC transporter signature motif; other site 760011005651 Walker B; other site 760011005652 D-loop; other site 760011005653 H-loop/switch region; other site 760011005654 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011005655 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005656 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011005657 TM-ABC transporter signature motif; other site 760011005658 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760011005659 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 760011005660 putative ligand binding site [chemical binding]; other site 760011005661 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 760011005662 active site 760011005663 catalytic triad [active] 760011005664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 760011005665 catalytic core [active] 760011005666 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 760011005667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 760011005668 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 760011005669 histidinol-phosphatase; Reviewed; Region: PRK08123 760011005670 active site 760011005671 dimer interface [polypeptide binding]; other site 760011005672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 760011005673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 760011005674 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 760011005675 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 760011005676 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 760011005677 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 760011005678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011005679 motif II; other site 760011005680 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 760011005681 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005682 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005683 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005684 Transposase [DNA replication, recombination, and repair]; Region: COG5421 760011005685 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 760011005686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 760011005687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 760011005688 DNA binding residues [nucleotide binding] 760011005689 dimerization interface [polypeptide binding]; other site 760011005690 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 760011005691 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 760011005692 NAD(P) binding site [chemical binding]; other site 760011005693 LDH/MDH dimer interface [polypeptide binding]; other site 760011005694 substrate binding site [chemical binding]; other site 760011005695 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011005696 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 760011005697 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005698 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011005699 TM-ABC transporter signature motif; other site 760011005700 SKIP/SNW domain; Region: SKIP_SNW; pfam02731 760011005701 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011005702 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011005703 Walker A/P-loop; other site 760011005704 ATP binding site [chemical binding]; other site 760011005705 Q-loop/lid; other site 760011005706 ABC transporter signature motif; other site 760011005707 Walker B; other site 760011005708 D-loop; other site 760011005709 H-loop/switch region; other site 760011005710 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011005711 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 760011005712 N- and C-terminal domain interface [polypeptide binding]; other site 760011005713 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 760011005714 active site 760011005715 putative catalytic site [active] 760011005716 metal binding site [ion binding]; metal-binding site 760011005717 ATP binding site [chemical binding]; other site 760011005718 carbohydrate binding site [chemical binding]; other site 760011005719 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 760011005720 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 760011005721 putative NAD(P) binding site [chemical binding]; other site 760011005722 catalytic Zn binding site [ion binding]; other site 760011005723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 760011005724 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 760011005725 NAD(P) binding site [chemical binding]; other site 760011005726 active site 760011005727 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 760011005728 active site 760011005729 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 760011005730 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 760011005731 tetramer interface [polypeptide binding]; other site 760011005732 TPP-binding site [chemical binding]; other site 760011005733 heterodimer interface [polypeptide binding]; other site 760011005734 phosphorylation loop region [posttranslational modification] 760011005735 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 760011005736 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 760011005737 PYR/PP interface [polypeptide binding]; other site 760011005738 dimer interface [polypeptide binding]; other site 760011005739 TPP binding site [chemical binding]; other site 760011005740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 760011005741 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 760011005742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 760011005743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 760011005744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 760011005745 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 760011005746 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 760011005747 E3 interaction surface; other site 760011005748 lipoyl attachment site [posttranslational modification]; other site 760011005749 e3 binding domain; Region: E3_binding; pfam02817 760011005750 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 760011005751 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 760011005752 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 760011005753 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 760011005754 Domain of unknown function (DUF718); Region: DUF718; pfam05336 760011005755 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005756 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011005757 TM-ABC transporter signature motif; other site 760011005758 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005759 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011005760 TM-ABC transporter signature motif; other site 760011005761 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011005762 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011005763 Walker A/P-loop; other site 760011005764 ATP binding site [chemical binding]; other site 760011005765 Q-loop/lid; other site 760011005766 ABC transporter signature motif; other site 760011005767 Walker B; other site 760011005768 D-loop; other site 760011005769 H-loop/switch region; other site 760011005770 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011005771 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 760011005772 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 760011005773 ligand binding site [chemical binding]; other site 760011005774 Uncharacterized conserved protein [Function unknown]; Region: COG3347 760011005775 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 760011005776 active site 760011005777 intersubunit interface [polypeptide binding]; other site 760011005778 Zn2+ binding site [ion binding]; other site 760011005779 L-rhamnose isomerase; Provisional; Region: PRK01076 760011005780 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 760011005781 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 760011005782 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 760011005783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011005784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011005785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011005786 DNA binding site [nucleotide binding] 760011005787 domain linker motif; other site 760011005788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 760011005789 dimerization interface [polypeptide binding]; other site 760011005790 ligand binding site [chemical binding]; other site 760011005791 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 760011005792 L-fucose isomerase; Provisional; Region: fucI; PRK10991 760011005793 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 760011005794 hexamer (dimer of trimers) interface [polypeptide binding]; other site 760011005795 trimer interface [polypeptide binding]; other site 760011005796 substrate binding site [chemical binding]; other site 760011005797 Mn binding site [ion binding]; other site 760011005798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 760011005799 putative substrate translocation pore; other site 760011005800 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 760011005801 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 760011005802 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 760011005803 metal binding site [ion binding]; metal-binding site 760011005804 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 760011005805 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005806 TM-ABC transporter signature motif; other site 760011005807 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 760011005808 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011005809 TM-ABC transporter signature motif; other site 760011005810 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011005811 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 760011005812 Walker A/P-loop; other site 760011005813 ATP binding site [chemical binding]; other site 760011005814 Q-loop/lid; other site 760011005815 ABC transporter signature motif; other site 760011005816 Walker B; other site 760011005817 D-loop; other site 760011005818 H-loop/switch region; other site 760011005819 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011005820 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 760011005821 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 760011005822 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 760011005823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 760011005824 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 760011005825 chaperone protein DnaJ; Provisional; Region: PRK10767 760011005826 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760011005827 HSP70 interaction site [polypeptide binding]; other site 760011005828 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 760011005829 substrate binding site [polypeptide binding]; other site 760011005830 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 760011005831 Zn binding sites [ion binding]; other site 760011005832 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 760011005833 dimer interface [polypeptide binding]; other site 760011005834 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 760011005835 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 760011005836 nucleotide binding site [chemical binding]; other site 760011005837 NEF interaction site [polypeptide binding]; other site 760011005838 SBD interface [polypeptide binding]; other site 760011005839 GrpE; Region: GrpE; pfam01025 760011005840 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 760011005841 dimer interface [polypeptide binding]; other site 760011005842 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 760011005843 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 760011005844 Malic enzyme, N-terminal domain; Region: malic; pfam00390 760011005845 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 760011005846 putative NAD(P) binding site [chemical binding]; other site 760011005847 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011005848 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011005849 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 760011005850 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 760011005851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 760011005852 motif I; other site 760011005853 active site 760011005854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011005855 motif II; other site 760011005856 GTP-binding protein Der; Reviewed; Region: PRK00093 760011005857 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 760011005858 G1 box; other site 760011005859 GTP/Mg2+ binding site [chemical binding]; other site 760011005860 Switch I region; other site 760011005861 G2 box; other site 760011005862 Switch II region; other site 760011005863 G3 box; other site 760011005864 G4 box; other site 760011005865 G5 box; other site 760011005866 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 760011005867 G1 box; other site 760011005868 GTP/Mg2+ binding site [chemical binding]; other site 760011005869 Switch I region; other site 760011005870 G2 box; other site 760011005871 G3 box; other site 760011005872 Switch II region; other site 760011005873 G4 box; other site 760011005874 G5 box; other site 760011005875 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 760011005876 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 760011005877 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 760011005878 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 760011005879 Sporulation and spore germination; Region: Germane; pfam10646 760011005880 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 760011005881 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 760011005882 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 760011005883 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 760011005884 putative active site [active] 760011005885 metal binding site [ion binding]; metal-binding site 760011005886 homodimer binding site [polypeptide binding]; other site 760011005887 phosphodiesterase; Provisional; Region: PRK12704 760011005888 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 760011005889 Zn2+ binding site [ion binding]; other site 760011005890 Mg2+ binding site [ion binding]; other site 760011005891 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 760011005892 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 760011005893 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 760011005894 alphaNTD homodimer interface [polypeptide binding]; other site 760011005895 alphaNTD - beta interaction site [polypeptide binding]; other site 760011005896 alphaNTD - beta' interaction site [polypeptide binding]; other site 760011005897 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 760011005898 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 760011005899 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 760011005900 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 760011005901 RNA binding surface [nucleotide binding]; other site 760011005902 30S ribosomal protein S11; Validated; Region: PRK05309 760011005903 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 760011005904 30S ribosomal protein S13; Region: bact_S13; TIGR03631 760011005905 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 760011005906 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 760011005907 SecY translocase; Region: SecY; pfam00344 760011005908 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 760011005909 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 760011005910 23S rRNA binding site [nucleotide binding]; other site 760011005911 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 760011005912 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 760011005913 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 760011005914 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 760011005915 23S rRNA interface [nucleotide binding]; other site 760011005916 L21e interface [polypeptide binding]; other site 760011005917 5S rRNA interface [nucleotide binding]; other site 760011005918 L27 interface [polypeptide binding]; other site 760011005919 L5 interface [polypeptide binding]; other site 760011005920 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 760011005921 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760011005922 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 760011005923 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 760011005924 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 760011005925 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 760011005926 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 760011005927 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 760011005928 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 760011005929 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 760011005930 RNA binding site [nucleotide binding]; other site 760011005931 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 760011005932 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 760011005933 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 760011005934 putative translocon interaction site; other site 760011005935 signal recognition particle (SRP54) interaction site; other site 760011005936 L23 interface [polypeptide binding]; other site 760011005937 trigger factor interaction site; other site 760011005938 23S rRNA interface [nucleotide binding]; other site 760011005939 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 760011005940 23S rRNA interface [nucleotide binding]; other site 760011005941 5S rRNA interface [nucleotide binding]; other site 760011005942 putative antibiotic binding site [chemical binding]; other site 760011005943 L25 interface [polypeptide binding]; other site 760011005944 L27 interface [polypeptide binding]; other site 760011005945 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 760011005946 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 760011005947 G-X-X-G motif; other site 760011005948 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 760011005949 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 760011005950 putative translocon binding site; other site 760011005951 protein-rRNA interface [nucleotide binding]; other site 760011005952 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 760011005953 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 760011005954 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 760011005955 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 760011005956 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 760011005957 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 760011005958 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 760011005959 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 760011005960 elongation factor Tu; Reviewed; Region: PRK00049 760011005961 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 760011005962 G1 box; other site 760011005963 GEF interaction site [polypeptide binding]; other site 760011005964 GTP/Mg2+ binding site [chemical binding]; other site 760011005965 Switch I region; other site 760011005966 G2 box; other site 760011005967 G3 box; other site 760011005968 Switch II region; other site 760011005969 G4 box; other site 760011005970 G5 box; other site 760011005971 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 760011005972 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 760011005973 Antibiotic Binding Site [chemical binding]; other site 760011005974 30S ribosomal protein S7; Validated; Region: PRK05302 760011005975 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 760011005976 S17 interaction site [polypeptide binding]; other site 760011005977 S8 interaction site; other site 760011005978 16S rRNA interaction site [nucleotide binding]; other site 760011005979 streptomycin interaction site [chemical binding]; other site 760011005980 23S rRNA interaction site [nucleotide binding]; other site 760011005981 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 760011005982 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 760011005983 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 760011005984 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 760011005985 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 760011005986 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 760011005987 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 760011005988 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 760011005989 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 760011005990 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 760011005991 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 760011005992 DNA binding site [nucleotide binding] 760011005993 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 760011005994 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 760011005995 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 760011005996 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 760011005997 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 760011005998 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 760011005999 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 760011006000 RPB10 interaction site [polypeptide binding]; other site 760011006001 RPB1 interaction site [polypeptide binding]; other site 760011006002 RPB11 interaction site [polypeptide binding]; other site 760011006003 RPB3 interaction site [polypeptide binding]; other site 760011006004 RPB12 interaction site [polypeptide binding]; other site 760011006005 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 760011006006 core dimer interface [polypeptide binding]; other site 760011006007 peripheral dimer interface [polypeptide binding]; other site 760011006008 L10 interface [polypeptide binding]; other site 760011006009 L11 interface [polypeptide binding]; other site 760011006010 putative EF-Tu interaction site [polypeptide binding]; other site 760011006011 putative EF-G interaction site [polypeptide binding]; other site 760011006012 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 760011006013 23S rRNA interface [nucleotide binding]; other site 760011006014 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 760011006015 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 760011006016 mRNA/rRNA interface [nucleotide binding]; other site 760011006017 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 760011006018 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 760011006019 23S rRNA interface [nucleotide binding]; other site 760011006020 L7/L12 interface [polypeptide binding]; other site 760011006021 putative thiostrepton binding site; other site 760011006022 L25 interface [polypeptide binding]; other site 760011006023 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 760011006024 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 760011006025 putative homodimer interface [polypeptide binding]; other site 760011006026 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 760011006027 heterodimer interface [polypeptide binding]; other site 760011006028 homodimer interface [polypeptide binding]; other site 760011006029 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 760011006030 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 760011006031 UMP phosphatase; Provisional; Region: PRK10444 760011006032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011006033 active site 760011006034 motif I; other site 760011006035 motif II; other site 760011006036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 760011006037 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 760011006038 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760011006039 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011006040 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 760011006041 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 760011006042 ATP-grasp domain; Region: ATP-grasp_4; cl17255 760011006043 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 760011006044 IMP binding site; other site 760011006045 dimer interface [polypeptide binding]; other site 760011006046 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 760011006047 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 760011006048 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 760011006049 catalytic site [active] 760011006050 subunit interface [polypeptide binding]; other site 760011006051 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011006052 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006053 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006057 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006058 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006060 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006061 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006062 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760011006063 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 760011006064 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 760011006065 active site 760011006066 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011006067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011006068 dimer interface [polypeptide binding]; other site 760011006069 conserved gate region; other site 760011006070 putative PBP binding loops; other site 760011006071 ABC-ATPase subunit interface; other site 760011006072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 760011006073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 760011006074 dimer interface [polypeptide binding]; other site 760011006075 conserved gate region; other site 760011006076 putative PBP binding loops; other site 760011006077 ABC-ATPase subunit interface; other site 760011006078 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 760011006079 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 760011006080 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 760011006081 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 760011006082 dimerization interface [polypeptide binding]; other site 760011006083 Histidine kinase; Region: His_kinase; pfam06580 760011006084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011006085 ATP binding site [chemical binding]; other site 760011006086 Mg2+ binding site [ion binding]; other site 760011006087 G-X-G motif; other site 760011006088 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 760011006089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 760011006090 active site 760011006091 phosphorylation site [posttranslational modification] 760011006092 intermolecular recognition site; other site 760011006093 dimerization interface [polypeptide binding]; other site 760011006094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011006095 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011006096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 760011006097 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 760011006098 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 760011006099 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498 760011006100 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 760011006101 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 760011006102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 760011006103 active site 760011006104 nucleotide binding site [chemical binding]; other site 760011006105 HIGH motif; other site 760011006106 KMSKS motif; other site 760011006107 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 760011006108 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 760011006109 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 760011006110 Citrate transporter; Region: CitMHS; pfam03600 760011006111 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 760011006112 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 760011006113 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 760011006114 citrate lyase subunit gamma; Provisional; Region: PRK13253 760011006115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 760011006116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 760011006117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 760011006118 dimerization interface [polypeptide binding]; other site 760011006119 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 760011006120 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 760011006121 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 760011006122 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006123 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006124 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006125 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006126 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006127 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006128 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006129 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006130 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006133 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 760011006134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 760011006135 FeS/SAM binding site; other site 760011006136 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 760011006137 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 760011006138 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 760011006139 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 760011006140 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 760011006141 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 760011006142 dimer interface [polypeptide binding]; other site 760011006143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011006144 catalytic residue [active] 760011006145 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 760011006146 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 760011006147 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 760011006148 trimerization site [polypeptide binding]; other site 760011006149 active site 760011006150 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 760011006151 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 760011006152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 760011006153 catalytic residue [active] 760011006154 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 760011006155 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 760011006156 FeS assembly protein SufB; Region: sufB; TIGR01980 760011006157 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 760011006158 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 760011006159 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 760011006160 Walker A/P-loop; other site 760011006161 ATP binding site [chemical binding]; other site 760011006162 Q-loop/lid; other site 760011006163 ABC transporter signature motif; other site 760011006164 Walker B; other site 760011006165 D-loop; other site 760011006166 H-loop/switch region; other site 760011006167 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 760011006168 dimer interface [polypeptide binding]; other site 760011006169 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 760011006170 putative radical transfer pathway; other site 760011006171 diiron center [ion binding]; other site 760011006172 tyrosyl radical; other site 760011006173 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364 760011006174 ATP cone domain; Region: ATP-cone; pfam03477 760011006175 Class I ribonucleotide reductase; Region: RNR_I; cd01679 760011006176 active site 760011006177 dimer interface [polypeptide binding]; other site 760011006178 catalytic residues [active] 760011006179 effector binding site; other site 760011006180 R2 peptide binding site; other site 760011006181 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 760011006182 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 760011006183 purine monophosphate binding site [chemical binding]; other site 760011006184 dimer interface [polypeptide binding]; other site 760011006185 putative catalytic residues [active] 760011006186 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 760011006187 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 760011006188 glutamate dehydrogenase; Provisional; Region: PRK09414 760011006189 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 760011006190 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 760011006191 NAD(P) binding site [chemical binding]; other site 760011006192 asparagine synthetase B; Provisional; Region: asnB; PRK09431 760011006193 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 760011006194 active site 760011006195 dimer interface [polypeptide binding]; other site 760011006196 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 760011006197 Ligand Binding Site [chemical binding]; other site 760011006198 Molecular Tunnel; other site 760011006199 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011006200 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006201 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006202 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006203 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006204 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006205 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006206 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006207 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006208 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006209 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006210 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006211 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006212 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006213 acetylornithine aminotransferase; Provisional; Region: PRK02627 760011006214 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 760011006215 inhibitor-cofactor binding pocket; inhibition site 760011006216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011006217 catalytic residue [active] 760011006218 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 760011006219 feedback inhibition sensing region; other site 760011006220 homohexameric interface [polypeptide binding]; other site 760011006221 nucleotide binding site [chemical binding]; other site 760011006222 N-acetyl-L-glutamate binding site [chemical binding]; other site 760011006223 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 760011006224 heterotetramer interface [polypeptide binding]; other site 760011006225 active site pocket [active] 760011006226 cleavage site 760011006227 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 760011006228 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 760011006229 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 760011006230 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 760011006231 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 760011006232 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 760011006233 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 760011006234 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 760011006235 MarR family; Region: MarR_2; pfam12802 760011006236 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 760011006237 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 760011006238 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 760011006239 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 760011006240 ANTAR domain; Region: ANTAR; pfam03861 760011006241 CTP synthetase; Validated; Region: pyrG; PRK05380 760011006242 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 760011006243 Catalytic site [active] 760011006244 active site 760011006245 UTP binding site [chemical binding]; other site 760011006246 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 760011006247 active site 760011006248 putative oxyanion hole; other site 760011006249 catalytic triad [active] 760011006250 Arginine repressor [Transcription]; Region: ArgR; COG1438 760011006251 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 760011006252 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 760011006253 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 760011006254 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 760011006255 active site 760011006256 dimer interface [polypeptide binding]; other site 760011006257 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 760011006258 dimer interface [polypeptide binding]; other site 760011006259 active site 760011006260 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 760011006261 6-phosphofructokinase; Region: PLN02884 760011006262 active site 760011006263 ADP/pyrophosphate binding site [chemical binding]; other site 760011006264 dimerization interface [polypeptide binding]; other site 760011006265 allosteric effector site; other site 760011006266 fructose-1,6-bisphosphate binding site; other site 760011006267 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 760011006268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 760011006269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 760011006270 homodimer interface [polypeptide binding]; other site 760011006271 catalytic residue [active] 760011006272 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 760011006273 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 760011006274 nucleotide binding pocket [chemical binding]; other site 760011006275 K-X-D-G motif; other site 760011006276 catalytic site [active] 760011006277 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 760011006278 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 760011006279 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 760011006280 active site 760011006281 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 760011006282 Dimer interface [polypeptide binding]; other site 760011006283 BRCT sequence motif; other site 760011006284 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 760011006285 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 760011006286 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 760011006287 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 760011006288 active site 760011006289 PHP Thumb interface [polypeptide binding]; other site 760011006290 metal binding site [ion binding]; metal-binding site 760011006291 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 760011006292 generic binding surface I; other site 760011006293 generic binding surface II; other site 760011006294 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 760011006295 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 760011006296 ATP binding site [chemical binding]; other site 760011006297 putative Mg++ binding site [ion binding]; other site 760011006298 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 760011006299 nucleotide binding region [chemical binding]; other site 760011006300 ATP-binding site [chemical binding]; other site 760011006301 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 760011006302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 760011006303 S-adenosylmethionine binding site [chemical binding]; other site 760011006304 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 760011006305 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 760011006306 active site 760011006307 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 760011006308 active site 2 [active] 760011006309 active site 1 [active] 760011006310 SlyX; Region: SlyX; pfam04102 760011006311 Rubredoxin [Energy production and conversion]; Region: COG1773 760011006312 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 760011006313 iron binding site [ion binding]; other site 760011006314 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006315 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006316 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006317 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006318 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006319 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006320 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006321 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006322 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006323 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006324 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006325 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006326 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006327 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 760011006328 FMN binding site [chemical binding]; other site 760011006329 dimer interface [polypeptide binding]; other site 760011006330 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 760011006331 putative dimer interface [polypeptide binding]; other site 760011006332 catalytic triad [active] 760011006333 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 760011006334 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 760011006335 dimer interface [polypeptide binding]; other site 760011006336 PYR/PP interface [polypeptide binding]; other site 760011006337 TPP binding site [chemical binding]; other site 760011006338 substrate binding site [chemical binding]; other site 760011006339 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 760011006340 Domain of unknown function; Region: EKR; cl11037 760011006341 4Fe-4S binding domain; Region: Fer4_6; pfam12837 760011006342 4Fe-4S binding domain; Region: Fer4; pfam00037 760011006343 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 760011006344 TPP-binding site [chemical binding]; other site 760011006345 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 760011006346 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 760011006347 oligomer interface [polypeptide binding]; other site 760011006348 active site 760011006349 metal binding site [ion binding]; metal-binding site 760011006350 Uncharacterized conserved protein [Function unknown]; Region: COG5476 760011006351 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 760011006352 MlrC C-terminus; Region: MlrC_C; pfam07171 760011006353 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 760011006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 760011006355 phosphorylation site [posttranslational modification] 760011006356 intermolecular recognition site; other site 760011006357 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 760011006358 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 760011006359 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 760011006360 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 760011006361 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 760011006362 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 760011006363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 760011006364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 760011006365 TM-ABC transporter signature motif; other site 760011006366 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 760011006367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 760011006368 Walker A/P-loop; other site 760011006369 ATP binding site [chemical binding]; other site 760011006370 Q-loop/lid; other site 760011006371 ABC transporter signature motif; other site 760011006372 Walker B; other site 760011006373 D-loop; other site 760011006374 H-loop/switch region; other site 760011006375 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 760011006376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 760011006377 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 760011006378 ligand binding site [chemical binding]; other site 760011006379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 760011006380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 760011006381 DNA binding site [nucleotide binding] 760011006382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 760011006383 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 760011006384 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 760011006385 active site 760011006386 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 760011006387 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 760011006388 CAP-like domain; other site 760011006389 active site 760011006390 primary dimer interface [polypeptide binding]; other site 760011006391 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 760011006392 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 760011006393 ATP binding site [chemical binding]; other site 760011006394 Mg2+ binding site [ion binding]; other site 760011006395 G-X-G motif; other site 760011006396 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 760011006397 anchoring element; other site 760011006398 dimer interface [polypeptide binding]; other site 760011006399 ATP binding site [chemical binding]; other site 760011006400 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 760011006401 active site 760011006402 putative metal-binding site [ion binding]; other site 760011006403 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 760011006404 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 760011006405 Mechanosensitive ion channel; Region: MS_channel; pfam00924 760011006406 heat shock protein 90; Provisional; Region: PRK05218 760011006407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011006408 ATP binding site [chemical binding]; other site 760011006409 Mg2+ binding site [ion binding]; other site 760011006410 G-X-G motif; other site 760011006411 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 760011006412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 760011006413 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 760011006414 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 760011006415 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 760011006416 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 760011006417 Prephenate dehydratase; Region: PDT; pfam00800 760011006418 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 760011006419 putative L-Phe binding site [chemical binding]; other site 760011006420 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 760011006421 endonuclease III; Region: ENDO3c; smart00478 760011006422 minor groove reading motif; other site 760011006423 helix-hairpin-helix signature motif; other site 760011006424 substrate binding pocket [chemical binding]; other site 760011006425 active site 760011006426 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 760011006427 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006428 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 760011006430 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 760011006431 putative active site [active] 760011006432 catalytic residue [active] 760011006433 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 760011006434 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 760011006435 active site 760011006436 catalytic site [active] 760011006437 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 760011006438 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 760011006439 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006440 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006441 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006442 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006443 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006444 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006445 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006446 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006447 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006448 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006449 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006450 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006451 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760011006452 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 760011006453 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 760011006454 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 760011006455 active site 760011006456 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 760011006457 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 760011006458 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 760011006459 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 760011006460 Catalytic dyad [active] 760011006461 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 760011006462 RNA methyltransferase, RsmE family; Region: TIGR00046 760011006463 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 760011006464 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 760011006465 Probable transposase; Region: OrfB_IS605; pfam01385 760011006466 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 760011006467 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 760011006468 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 760011006469 DNA binding residues [nucleotide binding] 760011006470 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 760011006471 catalytic residues [active] 760011006472 catalytic nucleophile [active] 760011006473 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 760011006474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 760011006475 Walker A motif; other site 760011006476 ATP binding site [chemical binding]; other site 760011006477 Walker B motif; other site 760011006478 recombination protein RecR; Reviewed; Region: recR; PRK00076 760011006479 RecR protein; Region: RecR; pfam02132 760011006480 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 760011006481 putative active site [active] 760011006482 putative metal-binding site [ion binding]; other site 760011006483 tetramer interface [polypeptide binding]; other site 760011006484 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 760011006485 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 760011006486 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 760011006487 NADP binding site [chemical binding]; other site 760011006488 homodimer interface [polypeptide binding]; other site 760011006489 active site 760011006490 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 760011006491 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 760011006492 putative metal binding site [ion binding]; other site 760011006493 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 760011006494 HSP70 interaction site [polypeptide binding]; other site 760011006495 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 760011006496 Trehalase; Region: Trehalase; cl17346 760011006497 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 760011006498 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 760011006499 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 760011006500 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 760011006501 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 760011006502 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 760011006503 active site 760011006504 dimer interface [polypeptide binding]; other site 760011006505 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 760011006506 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 760011006507 metal binding site [ion binding]; metal-binding site 760011006508 dimer interface [polypeptide binding]; other site 760011006509 Protein of unknown function (DUF3988); Region: DUF3988; pfam13149 760011006510 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006511 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006522 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006523 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 760011006524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 760011006525 putative acyl-acceptor binding pocket; other site 760011006526 N-terminal domain found in Bacteroides fragilis Nctc 9343 BF2867 and related proteins; Region: BF2867_like_N; cd13120 760011006527 C-terminal domain found in Bacteroides fragilisNctc 9343 BF2867 and related proteins; Region: BF2867_like_C; cd13121 760011006528 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006529 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006530 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006531 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006532 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006533 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006534 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006535 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006536 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 760011006537 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 760011006538 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 760011006539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 760011006540 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 760011006541 Protein of unknown function DUF45; Region: DUF45; pfam01863 760011006542 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 760011006543 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 760011006544 DNA repair protein RadA; Provisional; Region: PRK11823 760011006545 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 760011006546 Walker A motif; other site 760011006547 ATP binding site [chemical binding]; other site 760011006548 Walker B motif; other site 760011006549 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 760011006550 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 760011006551 active site 760011006552 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 760011006553 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 760011006554 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 760011006555 ParB-like nuclease domain; Region: ParB; smart00470 760011006556 KorB domain; Region: KorB; pfam08535 760011006557 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 760011006558 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760011006559 P-loop; other site 760011006560 Magnesium ion binding site [ion binding]; other site 760011006561 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 760011006562 Magnesium ion binding site [ion binding]; other site 760011006563 NifU-like domain; Region: NifU; pfam01106 760011006564 DNA gyrase subunit A; Validated; Region: PRK05560 760011006565 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 760011006566 CAP-like domain; other site 760011006567 active site 760011006568 primary dimer interface [polypeptide binding]; other site 760011006569 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760011006570 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760011006571 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760011006572 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760011006573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 760011006574 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 760011006575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 760011006576 ATP binding site [chemical binding]; other site 760011006577 Mg2+ binding site [ion binding]; other site 760011006578 G-X-G motif; other site 760011006579 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 760011006580 anchoring element; other site 760011006581 dimer interface [polypeptide binding]; other site 760011006582 ATP binding site [chemical binding]; other site 760011006583 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 760011006584 active site 760011006585 putative metal-binding site [ion binding]; other site 760011006586 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986