-- dump date 20140620_072446 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573413000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 573413000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 573413000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413000004 Walker A motif; other site 573413000005 ATP binding site [chemical binding]; other site 573413000006 Walker B motif; other site 573413000007 arginine finger; other site 573413000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573413000009 DnaA box-binding interface [nucleotide binding]; other site 573413000010 DNA polymerase III subunit beta; Provisional; Region: PRK14940 573413000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573413000012 putative DNA binding surface [nucleotide binding]; other site 573413000013 dimer interface [polypeptide binding]; other site 573413000014 beta-clamp/clamp loader binding surface; other site 573413000015 beta-clamp/translesion DNA polymerase binding surface; other site 573413000016 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 573413000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413000018 Walker A/P-loop; other site 573413000019 ATP binding site [chemical binding]; other site 573413000020 Q-loop/lid; other site 573413000021 Protein of unknown function (DUF721); Region: DUF721; pfam05258 573413000022 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 573413000023 Ribonuclease P; Region: Ribonuclease_P; pfam00825 573413000024 membrane protein insertase; Provisional; Region: PRK01318 573413000025 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 573413000026 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 573413000027 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 573413000028 G-X-X-G motif; other site 573413000029 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 573413000030 RxxxH motif; other site 573413000031 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573413000032 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573413000033 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573413000034 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573413000035 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 573413000036 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 573413000037 putative active site [active] 573413000038 putative metal binding site [ion binding]; other site 573413000039 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413000040 active site 573413000041 phosphorylation site [posttranslational modification] 573413000042 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413000043 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 573413000044 catalytic loop [active] 573413000045 iron binding site [ion binding]; other site 573413000046 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413000047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413000048 DNA binding site [nucleotide binding] 573413000049 domain linker motif; other site 573413000050 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413000051 dimerization interface [polypeptide binding]; other site 573413000052 ligand binding site [chemical binding]; other site 573413000053 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413000054 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 573413000055 active site 573413000056 metal binding site [ion binding]; metal-binding site 573413000057 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573413000058 SelR domain; Region: SelR; pfam01641 573413000059 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 573413000060 putative FMN binding site [chemical binding]; other site 573413000061 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 573413000062 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413000063 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573413000064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413000065 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413000066 substrate binding pocket [chemical binding]; other site 573413000067 membrane-bound complex binding site; other site 573413000068 hinge residues; other site 573413000069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413000070 Histidine kinase; Region: HisKA_2; pfam07568 573413000071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413000072 ATP binding site [chemical binding]; other site 573413000073 Mg2+ binding site [ion binding]; other site 573413000074 G-X-G motif; other site 573413000075 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413000076 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413000077 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413000078 putative active site [active] 573413000079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413000080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000081 putative PBP binding loops; other site 573413000082 dimer interface [polypeptide binding]; other site 573413000083 ABC-ATPase subunit interface; other site 573413000084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573413000085 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573413000086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000087 dimer interface [polypeptide binding]; other site 573413000088 conserved gate region; other site 573413000089 putative PBP binding loops; other site 573413000090 ABC-ATPase subunit interface; other site 573413000091 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413000092 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413000093 Walker A/P-loop; other site 573413000094 ATP binding site [chemical binding]; other site 573413000095 Q-loop/lid; other site 573413000096 ABC transporter signature motif; other site 573413000097 Walker B; other site 573413000098 D-loop; other site 573413000099 H-loop/switch region; other site 573413000100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573413000101 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 573413000102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413000103 Walker A/P-loop; other site 573413000104 ATP binding site [chemical binding]; other site 573413000105 Q-loop/lid; other site 573413000106 ABC transporter signature motif; other site 573413000107 Walker B; other site 573413000108 D-loop; other site 573413000109 H-loop/switch region; other site 573413000110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573413000111 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413000112 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 573413000113 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573413000114 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573413000115 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 573413000116 oligomer interface [polypeptide binding]; other site 573413000117 active site 573413000118 metal binding site [ion binding]; metal-binding site 573413000119 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413000120 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413000121 catalytic residue [active] 573413000122 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413000123 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 573413000124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413000125 dimerization interface [polypeptide binding]; other site 573413000126 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413000127 dimer interface [polypeptide binding]; other site 573413000128 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 573413000129 putative CheW interface [polypeptide binding]; other site 573413000130 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 573413000131 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 573413000132 metal binding site [ion binding]; metal-binding site 573413000133 dimer interface [polypeptide binding]; other site 573413000134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413000135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413000136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413000137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413000138 Outer membrane efflux protein; Region: OEP; pfam02321 573413000139 Outer membrane efflux protein; Region: OEP; pfam02321 573413000140 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 573413000141 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573413000142 carboxyltransferase (CT) interaction site; other site 573413000143 biotinylation site [posttranslational modification]; other site 573413000144 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413000145 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413000146 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413000147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413000148 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413000149 Zn2+ binding site [ion binding]; other site 573413000150 Mg2+ binding site [ion binding]; other site 573413000151 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573413000152 active site 573413000153 nucleophile elbow; other site 573413000154 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413000155 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573413000156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413000157 DNA binding site [nucleotide binding] 573413000158 domain linker motif; other site 573413000159 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413000160 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413000161 ligand binding site [chemical binding]; other site 573413000162 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413000163 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413000164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000165 dimer interface [polypeptide binding]; other site 573413000166 conserved gate region; other site 573413000167 putative PBP binding loops; other site 573413000168 ABC-ATPase subunit interface; other site 573413000169 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413000170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000171 dimer interface [polypeptide binding]; other site 573413000172 conserved gate region; other site 573413000173 putative PBP binding loops; other site 573413000174 ABC-ATPase subunit interface; other site 573413000175 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573413000176 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573413000177 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 573413000178 active site 573413000179 catalytic site [active] 573413000180 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 573413000181 amino acid transporter; Region: 2A0306; TIGR00909 573413000182 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 573413000183 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 573413000184 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 573413000185 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 573413000186 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 573413000187 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 573413000188 Substrate-binding site [chemical binding]; other site 573413000189 Substrate specificity [chemical binding]; other site 573413000190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413000191 DNA-binding site [nucleotide binding]; DNA binding site 573413000192 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413000193 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413000194 ligand binding site [chemical binding]; other site 573413000195 dimerization interface [polypeptide binding]; other site 573413000196 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413000197 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 573413000198 putative ligand binding site [chemical binding]; other site 573413000199 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413000200 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413000201 Walker A/P-loop; other site 573413000202 ATP binding site [chemical binding]; other site 573413000203 Q-loop/lid; other site 573413000204 ABC transporter signature motif; other site 573413000205 Walker B; other site 573413000206 D-loop; other site 573413000207 H-loop/switch region; other site 573413000208 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413000209 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000210 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413000211 TM-ABC transporter signature motif; other site 573413000212 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413000213 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413000214 nucleotide binding site [chemical binding]; other site 573413000215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413000216 Histidine kinase; Region: HisKA_2; pfam07568 573413000217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413000218 ATP binding site [chemical binding]; other site 573413000219 Mg2+ binding site [ion binding]; other site 573413000220 G-X-G motif; other site 573413000221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413000222 dimer interface [polypeptide binding]; other site 573413000223 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413000224 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413000225 dimer interface [polypeptide binding]; other site 573413000226 putative CheW interface [polypeptide binding]; other site 573413000227 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 573413000228 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 573413000229 domain interfaces; other site 573413000230 active site 573413000231 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 573413000232 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 573413000233 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573413000234 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573413000235 Walker A/P-loop; other site 573413000236 ATP binding site [chemical binding]; other site 573413000237 Q-loop/lid; other site 573413000238 ABC transporter signature motif; other site 573413000239 Walker B; other site 573413000240 D-loop; other site 573413000241 H-loop/switch region; other site 573413000242 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 573413000243 FeS assembly protein SufB; Region: sufB; TIGR01980 573413000244 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 573413000245 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573413000246 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573413000247 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573413000248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413000249 catalytic residue [active] 573413000250 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573413000251 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573413000252 trimerization site [polypeptide binding]; other site 573413000253 active site 573413000254 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413000255 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413000256 DNA binding site [nucleotide binding] 573413000257 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413000258 ligand binding site [chemical binding]; other site 573413000259 dimerization interface [polypeptide binding]; other site 573413000260 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413000261 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413000262 inhibitor site; inhibition site 573413000263 active site 573413000264 dimer interface [polypeptide binding]; other site 573413000265 catalytic residue [active] 573413000266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413000267 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413000268 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413000269 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 573413000270 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 573413000271 DAK2 domain; Region: Dak2; pfam02734 573413000272 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413000273 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413000274 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573413000275 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573413000276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413000277 Amidohydrolase; Region: Amidohydro_2; pfam04909 573413000278 Amidohydrolase; Region: Amidohydro_2; pfam04909 573413000279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413000280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413000281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413000282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413000283 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 573413000284 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573413000285 active site 573413000286 catalytic site [active] 573413000287 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573413000288 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573413000289 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 573413000290 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 573413000291 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573413000292 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573413000293 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573413000294 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573413000295 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 573413000296 Trehalase; Region: Trehalase; cl17346 573413000297 recombination protein RecR; Reviewed; Region: recR; PRK00076 573413000298 RecR protein; Region: RecR; pfam02132 573413000299 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573413000300 putative active site [active] 573413000301 putative metal-binding site [ion binding]; other site 573413000302 tetramer interface [polypeptide binding]; other site 573413000303 hypothetical protein; Validated; Region: PRK00153 573413000304 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06647 573413000305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413000306 Walker A motif; other site 573413000307 ATP binding site [chemical binding]; other site 573413000308 Walker B motif; other site 573413000309 arginine finger; other site 573413000310 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 573413000311 endonuclease IV; Provisional; Region: PRK01060 573413000312 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 573413000313 AP (apurinic/apyrimidinic) site pocket; other site 573413000314 DNA interaction; other site 573413000315 Metal-binding active site; metal-binding site 573413000316 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 573413000317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413000318 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573413000319 IHF dimer interface [polypeptide binding]; other site 573413000320 IHF - DNA interface [nucleotide binding]; other site 573413000321 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413000322 active site 573413000323 metal binding site [ion binding]; metal-binding site 573413000324 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 573413000325 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573413000326 active site 573413000327 ATP binding site [chemical binding]; other site 573413000328 substrate binding site [chemical binding]; other site 573413000329 activation loop (A-loop); other site 573413000330 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 573413000331 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573413000332 metal ion-dependent adhesion site (MIDAS); other site 573413000333 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413000334 EamA-like transporter family; Region: EamA; pfam00892 573413000335 EamA-like transporter family; Region: EamA; pfam00892 573413000336 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 573413000337 Zn binding site [ion binding]; other site 573413000338 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 573413000339 putative active site [active] 573413000340 nucleotide binding site [chemical binding]; other site 573413000341 nudix motif; other site 573413000342 putative metal binding site [ion binding]; other site 573413000343 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 573413000344 Hemerythrin; Region: Hemerythrin; cd12107 573413000345 Fe binding site [ion binding]; other site 573413000346 Hemerythrin; Region: Hemerythrin; cd12107 573413000347 Fe binding site [ion binding]; other site 573413000348 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 573413000349 A new structural DNA glycosylase; Region: AlkD_like; cd06561 573413000350 active site 573413000351 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 573413000352 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413000353 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413000354 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 573413000355 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573413000356 cytosine deaminase; Provisional; Region: PRK05985 573413000357 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 573413000358 active site 573413000359 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 573413000360 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573413000361 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573413000362 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 573413000363 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413000364 peptidase; Reviewed; Region: PRK13004 573413000365 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 573413000366 putative metal binding site [ion binding]; other site 573413000367 putative dimer interface [polypeptide binding]; other site 573413000368 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 573413000369 phenylhydantoinase; Validated; Region: PRK08323 573413000370 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 573413000371 tetramer interface [polypeptide binding]; other site 573413000372 active site 573413000373 peptidase; Reviewed; Region: PRK13004 573413000374 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413000375 metal binding site [ion binding]; metal-binding site 573413000376 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413000377 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413000378 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413000379 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413000380 Walker A/P-loop; other site 573413000381 ATP binding site [chemical binding]; other site 573413000382 Q-loop/lid; other site 573413000383 ABC transporter signature motif; other site 573413000384 Walker B; other site 573413000385 D-loop; other site 573413000386 H-loop/switch region; other site 573413000387 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413000388 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413000389 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000390 TM-ABC transporter signature motif; other site 573413000391 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000392 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413000393 TM-ABC transporter signature motif; other site 573413000394 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413000395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413000396 DNA-binding site [nucleotide binding]; DNA binding site 573413000397 UTRA domain; Region: UTRA; pfam07702 573413000398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573413000399 Transposase; Region: HTH_Tnp_1; pfam01527 573413000400 HTH-like domain; Region: HTH_21; pfam13276 573413000401 Integrase core domain; Region: rve; pfam00665 573413000402 DDE domain; Region: DDE_Tnp_IS240; pfam13610 573413000403 Integrase core domain; Region: rve_3; pfam13683 573413000404 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573413000405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413000406 Coenzyme A binding pocket [chemical binding]; other site 573413000407 Putative esterase; Region: Esterase; pfam00756 573413000408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 573413000409 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573413000410 Helix-turn-helix domain; Region: HTH_18; pfam12833 573413000411 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413000412 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 573413000413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 573413000414 YheO-like PAS domain; Region: PAS_6; pfam08348 573413000415 HTH domain; Region: HTH_22; pfam13309 573413000416 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 573413000417 Na2 binding site [ion binding]; other site 573413000418 putative substrate binding site 1 [chemical binding]; other site 573413000419 Na binding site 1 [ion binding]; other site 573413000420 putative substrate binding site 2 [chemical binding]; other site 573413000421 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 573413000422 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413000423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413000424 catalytic residue [active] 573413000425 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573413000426 homotrimer interaction site [polypeptide binding]; other site 573413000427 putative active site [active] 573413000428 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573413000429 trimer interface [polypeptide binding]; other site 573413000430 active site 573413000431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413000432 Zn2+ binding site [ion binding]; other site 573413000433 Mg2+ binding site [ion binding]; other site 573413000434 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413000435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413000436 active site 573413000437 phosphorylation site [posttranslational modification] 573413000438 intermolecular recognition site; other site 573413000439 dimerization interface [polypeptide binding]; other site 573413000440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413000441 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573413000442 Walker A motif; other site 573413000443 ATP binding site [chemical binding]; other site 573413000444 Walker B motif; other site 573413000445 arginine finger; other site 573413000446 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573413000447 anti sigma factor interaction site; other site 573413000448 regulatory phosphorylation site [posttranslational modification]; other site 573413000449 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 573413000450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413000451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 573413000452 DNA binding site [nucleotide binding] 573413000453 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413000454 HSP70 interaction site [polypeptide binding]; other site 573413000455 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573413000456 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573413000457 hinge; other site 573413000458 active site 573413000459 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 573413000460 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 573413000461 Glycosyl transferase WecB/TagA/CpsF family; Region: Glyco_tran_WecB; pfam03808 573413000462 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573413000463 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 573413000464 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 573413000465 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 573413000466 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 573413000467 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 573413000468 Catalytic dyad [active] 573413000469 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573413000470 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573413000471 P-loop; other site 573413000472 Protein of unknown function (DUF342); Region: DUF342; pfam03961 573413000473 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 573413000474 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573413000475 putative binding surface; other site 573413000476 active site 573413000477 Melibiase; Region: Melibiase; pfam02065 573413000478 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573413000479 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 573413000480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413000481 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573413000482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413000483 DNA binding residues [nucleotide binding] 573413000484 Response regulator receiver domain; Region: Response_reg; pfam00072 573413000485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413000486 active site 573413000487 phosphorylation site [posttranslational modification] 573413000488 intermolecular recognition site; other site 573413000489 dimerization interface [polypeptide binding]; other site 573413000490 High-affinity nickel-transport protein; Region: NicO; cl00964 573413000491 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 573413000492 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573413000493 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573413000494 G1 box; other site 573413000495 GTP/Mg2+ binding site [chemical binding]; other site 573413000496 Switch I region; other site 573413000497 G2 box; other site 573413000498 G3 box; other site 573413000499 Switch II region; other site 573413000500 G4 box; other site 573413000501 G5 box; other site 573413000502 Nucleoside recognition; Region: Gate; pfam07670 573413000503 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573413000504 Nucleoside recognition; Region: Gate; pfam07670 573413000505 FeoA domain; Region: FeoA; pfam04023 573413000506 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 573413000507 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 573413000508 THF binding site; other site 573413000509 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 573413000510 substrate binding site [chemical binding]; other site 573413000511 THF binding site; other site 573413000512 zinc-binding site [ion binding]; other site 573413000513 FeoA domain; Region: FeoA; pfam04023 573413000514 FeoA domain; Region: FeoA; pfam04023 573413000515 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 573413000516 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573413000517 G1 box; other site 573413000518 GTP/Mg2+ binding site [chemical binding]; other site 573413000519 Switch I region; other site 573413000520 G2 box; other site 573413000521 G3 box; other site 573413000522 Switch II region; other site 573413000523 G4 box; other site 573413000524 G5 box; other site 573413000525 Nucleoside recognition; Region: Gate; pfam07670 573413000526 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573413000527 Nucleoside recognition; Region: Gate; pfam07670 573413000528 Protein of unknown function (DUF2023); Region: DUF2023; pfam09633 573413000529 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573413000530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413000531 Zn2+ binding site [ion binding]; other site 573413000532 Mg2+ binding site [ion binding]; other site 573413000533 flavodoxin FldA; Validated; Region: PRK09267 573413000534 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 573413000535 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 573413000536 active site 573413000537 C-terminal domain interface [polypeptide binding]; other site 573413000538 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 573413000539 active site 573413000540 N-terminal domain interface [polypeptide binding]; other site 573413000541 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 573413000542 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573413000543 N-terminal plug; other site 573413000544 ligand-binding site [chemical binding]; other site 573413000545 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 573413000546 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 573413000547 putative dimer interface [polypeptide binding]; other site 573413000548 active site pocket [active] 573413000549 putative cataytic base [active] 573413000550 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 573413000551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413000552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413000553 homodimer interface [polypeptide binding]; other site 573413000554 catalytic residue [active] 573413000555 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 573413000556 cobyric acid synthase; Provisional; Region: PRK00784 573413000557 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413000558 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413000559 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 573413000560 catalytic triad [active] 573413000561 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413000562 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413000563 intersubunit interface [polypeptide binding]; other site 573413000564 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413000565 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413000566 ABC-ATPase subunit interface; other site 573413000567 dimer interface [polypeptide binding]; other site 573413000568 putative PBP binding regions; other site 573413000569 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413000570 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413000571 Walker A/P-loop; other site 573413000572 ATP binding site [chemical binding]; other site 573413000573 Q-loop/lid; other site 573413000574 ABC transporter signature motif; other site 573413000575 Walker B; other site 573413000576 D-loop; other site 573413000577 H-loop/switch region; other site 573413000578 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 573413000579 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413000580 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 573413000581 catalytic triad [active] 573413000582 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 573413000583 Precorrin-8X methylmutase; Region: CbiC; pfam02570 573413000584 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 573413000585 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 573413000586 active site 573413000587 putative homodimer interface [polypeptide binding]; other site 573413000588 SAM binding site [chemical binding]; other site 573413000589 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 573413000590 active site 573413000591 SAM binding site [chemical binding]; other site 573413000592 homodimer interface [polypeptide binding]; other site 573413000593 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 573413000594 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 573413000595 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 573413000596 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 573413000597 active site 573413000598 SAM binding site [chemical binding]; other site 573413000599 homodimer interface [polypeptide binding]; other site 573413000600 Cysteine-rich small domain; Region: zf-like; cl00946 573413000601 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573413000602 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 573413000603 active site 573413000604 catalytic triad [active] 573413000605 dimer interface [polypeptide binding]; other site 573413000606 PIN domain; Region: PIN_3; pfam13470 573413000607 HicB family; Region: HicB; pfam05534 573413000608 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 573413000609 active site 573413000610 SAM binding site [chemical binding]; other site 573413000611 homodimer interface [polypeptide binding]; other site 573413000612 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573413000613 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 573413000614 putative PBP binding regions; other site 573413000615 ABC-ATPase subunit interface; other site 573413000616 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573413000617 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573413000618 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 573413000619 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573413000620 putative metal binding residues [ion binding]; other site 573413000621 hypothetical protein; Region: PHA01748 573413000622 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413000623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413000624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573413000625 dimerization interface [polypeptide binding]; other site 573413000626 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413000627 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573413000628 NAD(P) binding site [chemical binding]; other site 573413000629 active site 573413000630 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413000631 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413000632 inhibitor site; inhibition site 573413000633 active site 573413000634 dimer interface [polypeptide binding]; other site 573413000635 catalytic residue [active] 573413000636 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 573413000637 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573413000638 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413000639 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413000640 acetylornithine deacetylase; Provisional; Region: PRK07522 573413000641 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 573413000642 metal binding site [ion binding]; metal-binding site 573413000643 putative dimer interface [polypeptide binding]; other site 573413000644 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 573413000645 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 573413000646 FeoC like transcriptional regulator; Region: FeoC; cl17677 573413000647 Flagellin N-methylase; Region: FliB; pfam03692 573413000648 cyclase homology domain; Region: CHD; cd07302 573413000649 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413000650 nucleotidyl binding site; other site 573413000651 metal binding site [ion binding]; metal-binding site 573413000652 dimer interface [polypeptide binding]; other site 573413000653 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573413000654 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 573413000655 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 573413000656 active site 573413000657 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573413000658 Cation efflux family; Region: Cation_efflux; pfam01545 573413000659 phosphoglyceromutase; Provisional; Region: PRK05434 573413000660 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 573413000661 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413000662 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413000663 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413000664 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 573413000665 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413000666 ligand binding site [chemical binding]; other site 573413000667 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413000668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413000669 Walker A/P-loop; other site 573413000670 ATP binding site [chemical binding]; other site 573413000671 Q-loop/lid; other site 573413000672 ABC transporter signature motif; other site 573413000673 Walker B; other site 573413000674 D-loop; other site 573413000675 H-loop/switch region; other site 573413000676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413000677 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000678 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413000679 TM-ABC transporter signature motif; other site 573413000680 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000681 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413000682 TM-ABC transporter signature motif; other site 573413000683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413000684 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 573413000685 nucleotide binding site [chemical binding]; other site 573413000686 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 573413000687 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 573413000688 DOMON domain; Region: DOMON; pfam03351 573413000689 putative ligand binding site [chemical binding]; other site 573413000690 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573413000691 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573413000692 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413000693 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413000694 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413000695 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573413000696 intersubunit interface [polypeptide binding]; other site 573413000697 active site 573413000698 Zn2+ binding site [ion binding]; other site 573413000699 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413000700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413000701 DNA binding site [nucleotide binding] 573413000702 domain linker motif; other site 573413000703 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413000704 ligand binding site [chemical binding]; other site 573413000705 dimerization interface [polypeptide binding]; other site 573413000706 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 573413000707 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413000708 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 573413000709 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 573413000710 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413000711 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 573413000712 ligand binding site [chemical binding]; other site 573413000713 dimerization interface [polypeptide binding]; other site 573413000714 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 573413000715 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413000716 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413000717 Walker A/P-loop; other site 573413000718 ATP binding site [chemical binding]; other site 573413000719 Q-loop/lid; other site 573413000720 ABC transporter signature motif; other site 573413000721 Walker B; other site 573413000722 D-loop; other site 573413000723 H-loop/switch region; other site 573413000724 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413000725 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413000726 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413000727 TM-ABC transporter signature motif; other site 573413000728 aspartate aminotransferase; Provisional; Region: PRK06836 573413000729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413000730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413000731 homodimer interface [polypeptide binding]; other site 573413000732 catalytic residue [active] 573413000733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 573413000734 YheO-like PAS domain; Region: PAS_6; pfam08348 573413000735 HTH domain; Region: HTH_22; pfam13309 573413000736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 573413000737 YheO-like PAS domain; Region: PAS_6; pfam08348 573413000738 HTH domain; Region: HTH_22; pfam13309 573413000739 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 573413000740 Na binding site [ion binding]; other site 573413000741 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 573413000742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413000743 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573413000744 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573413000745 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413000746 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573413000747 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573413000748 substrate binding pocket [chemical binding]; other site 573413000749 chain length determination region; other site 573413000750 substrate-Mg2+ binding site; other site 573413000751 catalytic residues [active] 573413000752 aspartate-rich region 1; other site 573413000753 active site lid residues [active] 573413000754 aspartate-rich region 2; other site 573413000755 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413000756 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413000757 photolyase PhrII; Region: phr2; TIGR00591 573413000758 DNA photolyase; Region: DNA_photolyase; pfam00875 573413000759 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 573413000760 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573413000761 DHH family; Region: DHH; pfam01368 573413000762 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573413000763 Flavodoxin domain; Region: Flavodoxin_5; cl17428 573413000764 Protein of unknown function (DUF401); Region: DUF401; cl00830 573413000765 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573413000766 metal binding site 2 [ion binding]; metal-binding site 573413000767 putative DNA binding helix; other site 573413000768 metal binding site 1 [ion binding]; metal-binding site 573413000769 dimer interface [polypeptide binding]; other site 573413000770 structural Zn2+ binding site [ion binding]; other site 573413000771 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 573413000772 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 573413000773 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 573413000774 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573413000775 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 573413000776 switch II; other site 573413000777 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 573413000778 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 573413000779 P loop nucleotide binding; other site 573413000780 switch II; other site 573413000781 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 573413000782 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573413000783 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 573413000784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413000785 dimerization interface [polypeptide binding]; other site 573413000786 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413000787 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413000788 dimer interface [polypeptide binding]; other site 573413000789 putative CheW interface [polypeptide binding]; other site 573413000790 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 573413000791 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 573413000792 Glycosyl hydrolase family 79, N-terminal domain; Region: Glyco_hydro_79n; pfam03662 573413000793 Predicted secreted protein (DUF2259); Region: DUF2259; cl02309 573413000794 prolyl-tRNA synthetase; Provisional; Region: PRK08661 573413000795 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 573413000796 dimer interface [polypeptide binding]; other site 573413000797 motif 1; other site 573413000798 active site 573413000799 motif 2; other site 573413000800 motif 3; other site 573413000801 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 573413000802 anticodon binding site; other site 573413000803 zinc-binding site [ion binding]; other site 573413000804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413000805 NAD(P) binding site [chemical binding]; other site 573413000806 active site 573413000807 NAD synthetase; Provisional; Region: PRK13981 573413000808 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573413000809 multimer interface [polypeptide binding]; other site 573413000810 active site 573413000811 catalytic triad [active] 573413000812 protein interface 1 [polypeptide binding]; other site 573413000813 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573413000814 homodimer interface [polypeptide binding]; other site 573413000815 NAD binding pocket [chemical binding]; other site 573413000816 ATP binding pocket [chemical binding]; other site 573413000817 Mg binding site [ion binding]; other site 573413000818 active-site loop [active] 573413000819 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573413000820 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573413000821 active site 573413000822 catalytic site [active] 573413000823 Bifunctional nuclease; Region: DNase-RNase; pfam02577 573413000824 UvrB/uvrC motif; Region: UVR; pfam02151 573413000825 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 573413000826 active site 573413000827 butyrate kinase; Provisional; Region: PRK03011 573413000828 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573413000829 putative active site [active] 573413000830 catalytic residue [active] 573413000831 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 573413000832 PGAP1-like protein; Region: PGAP1; pfam07819 573413000833 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 573413000834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413000835 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413000836 active site 573413000837 catalytic tetrad [active] 573413000838 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573413000839 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573413000840 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573413000841 catalytic residue [active] 573413000842 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 573413000843 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 573413000844 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 573413000845 Prephenate dehydratase; Region: PDT; pfam00800 573413000846 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573413000847 putative L-Phe binding site [chemical binding]; other site 573413000848 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 573413000849 hypothetical protein; Validated; Region: PRK07121 573413000850 Predicted oxidoreductase [General function prediction only]; Region: COG3573 573413000851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413000852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413000853 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 573413000854 dimerization interface [polypeptide binding]; other site 573413000855 substrate binding pocket [chemical binding]; other site 573413000856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413000857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413000858 PAS domain; Region: PAS_9; pfam13426 573413000859 putative active site [active] 573413000860 heme pocket [chemical binding]; other site 573413000861 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413000862 cyclase homology domain; Region: CHD; cd07302 573413000863 nucleotidyl binding site; other site 573413000864 metal binding site [ion binding]; metal-binding site 573413000865 dimer interface [polypeptide binding]; other site 573413000866 HEAT repeats; Region: HEAT_2; pfam13646 573413000867 HEAT repeats; Region: HEAT_2; pfam13646 573413000868 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 573413000869 protein binding surface [polypeptide binding]; other site 573413000870 HEAT repeats; Region: HEAT_2; pfam13646 573413000871 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 573413000872 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573413000873 HIGH motif; other site 573413000874 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573413000875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413000876 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 573413000877 active site 573413000878 KMSKS motif; other site 573413000879 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573413000880 tRNA binding surface [nucleotide binding]; other site 573413000881 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573413000882 Domain of unknown function DUF21; Region: DUF21; pfam01595 573413000883 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573413000884 Transporter associated domain; Region: CorC_HlyC; smart01091 573413000885 heat shock protein 90; Provisional; Region: PRK05218 573413000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413000887 ATP binding site [chemical binding]; other site 573413000888 Mg2+ binding site [ion binding]; other site 573413000889 G-X-G motif; other site 573413000890 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 573413000891 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 573413000892 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 573413000893 Response regulator receiver domain; Region: Response_reg; pfam00072 573413000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413000895 active site 573413000896 phosphorylation site [posttranslational modification] 573413000897 intermolecular recognition site; other site 573413000898 dimerization interface [polypeptide binding]; other site 573413000899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 573413000900 active site 573413000901 phosphorylation site [posttranslational modification] 573413000902 intermolecular recognition site; other site 573413000903 dimerization interface [polypeptide binding]; other site 573413000904 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573413000905 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573413000906 anti sigma factor interaction site; other site 573413000907 regulatory phosphorylation site [posttranslational modification]; other site 573413000908 Predicted transcriptional regulators [Transcription]; Region: COG1695 573413000909 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573413000910 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573413000911 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413000912 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413000913 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413000914 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 573413000915 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413000916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573413000917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413000918 putative DNA binding site [nucleotide binding]; other site 573413000919 putative Zn2+ binding site [ion binding]; other site 573413000920 NlpC/P60 family; Region: NLPC_P60; cl17555 573413000921 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 573413000922 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 573413000923 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 573413000924 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573413000925 adenosine deaminase; Provisional; Region: PRK09358 573413000926 active site 573413000927 B12 binding domain; Region: B12-binding; pfam02310 573413000928 B12 binding site [chemical binding]; other site 573413000929 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 573413000930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413000931 FeS/SAM binding site; other site 573413000932 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413000933 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 573413000934 N- and C-terminal domain interface [polypeptide binding]; other site 573413000935 active site 573413000936 MgATP binding site [chemical binding]; other site 573413000937 catalytic site [active] 573413000938 metal binding site [ion binding]; metal-binding site 573413000939 carbohydrate binding site [chemical binding]; other site 573413000940 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573413000941 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573413000942 intersubunit interface [polypeptide binding]; other site 573413000943 active site 573413000944 Zn2+ binding site [ion binding]; other site 573413000945 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 573413000946 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413000947 AP (apurinic/apyrimidinic) site pocket; other site 573413000948 DNA interaction; other site 573413000949 Metal-binding active site; metal-binding site 573413000950 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 573413000951 active site 573413000952 dimer interface [polypeptide binding]; other site 573413000953 magnesium binding site [ion binding]; other site 573413000954 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 573413000955 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573413000956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413000957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413000958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000959 dimer interface [polypeptide binding]; other site 573413000960 conserved gate region; other site 573413000961 putative PBP binding loops; other site 573413000962 ABC-ATPase subunit interface; other site 573413000963 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413000964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413000965 dimer interface [polypeptide binding]; other site 573413000966 conserved gate region; other site 573413000967 putative PBP binding loops; other site 573413000968 ABC-ATPase subunit interface; other site 573413000969 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413000970 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413000971 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573413000972 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413000973 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573413000974 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573413000975 dimer interface [polypeptide binding]; other site 573413000976 anticodon binding site; other site 573413000977 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573413000978 homodimer interface [polypeptide binding]; other site 573413000979 motif 1; other site 573413000980 active site 573413000981 motif 2; other site 573413000982 GAD domain; Region: GAD; pfam02938 573413000983 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 573413000984 motif 3; other site 573413000985 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573413000986 putative active site [active] 573413000987 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 573413000988 Predicted methyltransferases [General function prediction only]; Region: COG0313 573413000989 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573413000990 putative SAM binding site [chemical binding]; other site 573413000991 putative homodimer interface [polypeptide binding]; other site 573413000992 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 573413000993 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413000994 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413000995 active site 573413000996 NAD binding site [chemical binding]; other site 573413000997 metal binding site [ion binding]; metal-binding site 573413000998 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573413000999 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573413001000 catalytic residues [active] 573413001001 HDOD domain; Region: HDOD; pfam08668 573413001002 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413001003 Zn2+ binding site [ion binding]; other site 573413001004 Mg2+ binding site [ion binding]; other site 573413001005 AAA domain; Region: AAA_32; pfam13654 573413001006 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 573413001007 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573413001008 Uncharacterized conserved protein [Function unknown]; Region: COG0327 573413001009 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 573413001010 signal peptidase II; Provisional; Region: lspA; PRK01574 573413001011 lipoprotein signal peptidase; Provisional; Region: PRK14787 573413001012 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 573413001013 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413001014 peroxiredoxin; Provisional; Region: PRK13189 573413001015 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 573413001016 dimer interface [polypeptide binding]; other site 573413001017 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573413001018 catalytic triad [active] 573413001019 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573413001020 metal binding site 2 [ion binding]; metal-binding site 573413001021 putative DNA binding helix; other site 573413001022 metal binding site 1 [ion binding]; metal-binding site 573413001023 dimer interface [polypeptide binding]; other site 573413001024 structural Zn2+ binding site [ion binding]; other site 573413001025 FlgD Tudor-like domain; Region: FLgD_tudor; cl17881 573413001026 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573413001027 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573413001028 putative acyl-acceptor binding pocket; other site 573413001029 phenylhydantoinase; Validated; Region: PRK08323 573413001030 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413001031 active site 573413001032 TPR repeat; Region: TPR_11; pfam13414 573413001033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413001034 binding surface 573413001035 TPR motif; other site 573413001036 TPR repeat; Region: TPR_11; pfam13414 573413001037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413001038 TPR motif; other site 573413001039 binding surface 573413001040 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 573413001041 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 573413001042 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 573413001043 putative active site [active] 573413001044 putative metal binding site [ion binding]; other site 573413001045 Predicted transcriptional regulators [Transcription]; Region: COG1378 573413001046 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 573413001047 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 573413001048 C-terminal domain interface [polypeptide binding]; other site 573413001049 sugar binding site [chemical binding]; other site 573413001050 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573413001051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413001052 motif II; other site 573413001053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413001054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413001055 putative substrate translocation pore; other site 573413001056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413001057 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165 573413001058 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573413001059 putative ligand binding site [chemical binding]; other site 573413001060 NAD binding site [chemical binding]; other site 573413001061 dimer interface [polypeptide binding]; other site 573413001062 putative catalytic site [active] 573413001063 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 573413001064 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 573413001065 dimerization interface [polypeptide binding]; other site 573413001066 domain crossover interface; other site 573413001067 redox-dependent activation switch; other site 573413001068 methionine sulfoxide reductase A; Provisional; Region: PRK14054 573413001069 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573413001070 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 573413001071 dimerization interface [polypeptide binding]; other site 573413001072 ligand binding site [chemical binding]; other site 573413001073 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413001074 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573413001075 TM-ABC transporter signature motif; other site 573413001076 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 573413001077 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573413001078 TM-ABC transporter signature motif; other site 573413001079 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573413001080 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573413001081 Walker A/P-loop; other site 573413001082 ATP binding site [chemical binding]; other site 573413001083 Q-loop/lid; other site 573413001084 ABC transporter signature motif; other site 573413001085 Walker B; other site 573413001086 D-loop; other site 573413001087 H-loop/switch region; other site 573413001088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573413001089 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573413001090 Walker A/P-loop; other site 573413001091 ATP binding site [chemical binding]; other site 573413001092 Q-loop/lid; other site 573413001093 ABC transporter signature motif; other site 573413001094 Walker B; other site 573413001095 D-loop; other site 573413001096 H-loop/switch region; other site 573413001097 FOG: CBS domain [General function prediction only]; Region: COG0517 573413001098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 573413001099 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413001100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413001101 substrate binding pocket [chemical binding]; other site 573413001102 membrane-bound complex binding site; other site 573413001103 hinge residues; other site 573413001104 PAS domain; Region: PAS_9; pfam13426 573413001105 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413001106 Histidine kinase; Region: HisKA_2; pfam07568 573413001107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001108 ATP binding site [chemical binding]; other site 573413001109 Mg2+ binding site [ion binding]; other site 573413001110 G-X-G motif; other site 573413001111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413001112 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413001113 Walker A/P-loop; other site 573413001114 ATP binding site [chemical binding]; other site 573413001115 Q-loop/lid; other site 573413001116 ABC transporter signature motif; other site 573413001117 Walker B; other site 573413001118 D-loop; other site 573413001119 H-loop/switch region; other site 573413001120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573413001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001122 dimer interface [polypeptide binding]; other site 573413001123 conserved gate region; other site 573413001124 putative PBP binding loops; other site 573413001125 ABC-ATPase subunit interface; other site 573413001126 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413001127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413001128 substrate binding pocket [chemical binding]; other site 573413001129 membrane-bound complex binding site; other site 573413001130 hinge residues; other site 573413001131 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 573413001132 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573413001133 putative dimer interface [polypeptide binding]; other site 573413001134 [2Fe-2S] cluster binding site [ion binding]; other site 573413001135 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413001136 dimer interface [polypeptide binding]; other site 573413001137 [2Fe-2S] cluster binding site [ion binding]; other site 573413001138 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573413001139 SLBB domain; Region: SLBB; pfam10531 573413001140 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573413001141 4Fe-4S binding domain; Region: Fer4; pfam00037 573413001142 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413001143 4Fe-4S binding domain; Region: Fer4; pfam00037 573413001144 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413001145 catalytic loop [active] 573413001146 iron binding site [ion binding]; other site 573413001147 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573413001148 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413001149 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413001150 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413001151 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573413001152 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573413001153 putative dimer interface [polypeptide binding]; other site 573413001154 [2Fe-2S] cluster binding site [ion binding]; other site 573413001155 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573413001156 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 573413001157 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 573413001158 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 573413001159 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 573413001160 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 573413001161 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 573413001162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413001163 Walker A/P-loop; other site 573413001164 ATP binding site [chemical binding]; other site 573413001165 Q-loop/lid; other site 573413001166 ABC transporter signature motif; other site 573413001167 Walker B; other site 573413001168 D-loop; other site 573413001169 H-loop/switch region; other site 573413001170 Protein of unknown function DUF89; Region: DUF89; cl15397 573413001171 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 573413001172 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413001173 putative active site [active] 573413001174 metal binding site [ion binding]; metal-binding site 573413001175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413001176 Histidine kinase; Region: HisKA_2; pfam07568 573413001177 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573413001178 ATP binding site [chemical binding]; other site 573413001179 Mg2+ binding site [ion binding]; other site 573413001180 G-X-G motif; other site 573413001181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573413001182 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413001183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413001184 Cache domain; Region: Cache_2; pfam08269 573413001185 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573413001186 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413001187 dimerization interface [polypeptide binding]; other site 573413001188 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413001189 dimer interface [polypeptide binding]; other site 573413001190 putative CheW interface [polypeptide binding]; other site 573413001191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413001192 Histidine kinase; Region: HisKA_2; pfam07568 573413001193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001194 ATP binding site [chemical binding]; other site 573413001195 Mg2+ binding site [ion binding]; other site 573413001196 G-X-G motif; other site 573413001197 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 573413001198 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 573413001199 PAS fold; Region: PAS_4; pfam08448 573413001200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413001201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413001202 metal binding site [ion binding]; metal-binding site 573413001203 active site 573413001204 I-site; other site 573413001205 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 573413001206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413001207 putative substrate translocation pore; other site 573413001208 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 573413001209 active site 573413001210 putative catalytic site [active] 573413001211 phosphate binding site A [ion binding]; other site 573413001212 DNA binding site [nucleotide binding] 573413001213 metal binding site A [ion binding]; metal-binding site 573413001214 putative AP binding site [nucleotide binding]; other site 573413001215 putative metal binding site B [ion binding]; other site 573413001216 phosphate binding site B [ion binding]; other site 573413001217 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413001218 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413001219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413001220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413001221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001222 dimer interface [polypeptide binding]; other site 573413001223 conserved gate region; other site 573413001224 putative PBP binding loops; other site 573413001225 ABC-ATPase subunit interface; other site 573413001226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413001227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001228 dimer interface [polypeptide binding]; other site 573413001229 conserved gate region; other site 573413001230 putative PBP binding loops; other site 573413001231 ABC-ATPase subunit interface; other site 573413001232 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413001233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001234 active site 573413001235 phosphorylation site [posttranslational modification] 573413001236 intermolecular recognition site; other site 573413001237 dimerization interface [polypeptide binding]; other site 573413001238 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413001239 DNA binding residues [nucleotide binding] 573413001240 dimerization interface [polypeptide binding]; other site 573413001241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413001242 Histidine kinase; Region: HisKA_3; pfam07730 573413001243 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 573413001244 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413001245 active site 573413001246 putative substrate binding pocket [chemical binding]; other site 573413001247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413001248 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 573413001249 phosphate binding site [ion binding]; other site 573413001250 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 573413001251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413001252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413001253 4Fe-4S binding domain; Region: Fer4; pfam00037 573413001254 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413001255 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 573413001256 putative active site [active] 573413001257 metal binding site [ion binding]; metal-binding site 573413001258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413001259 oxidoreductase; Provisional; Region: PRK06196 573413001260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413001261 NAD(P) binding site [chemical binding]; other site 573413001262 active site 573413001263 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 573413001264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413001265 NAD(P) binding site [chemical binding]; other site 573413001266 active site 573413001267 Divergent AAA domain; Region: AAA_4; pfam04326 573413001268 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 573413001269 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 573413001270 PIN domain; Region: PIN_3; pfam13470 573413001271 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573413001272 active site 573413001273 NTP binding site [chemical binding]; other site 573413001274 metal binding triad [ion binding]; metal-binding site 573413001275 antibiotic binding site [chemical binding]; other site 573413001276 HEPN domain; Region: HEPN; pfam05168 573413001277 YaaC-like Protein; Region: YaaC; pfam14175 573413001278 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 573413001279 AAA domain; Region: AAA_14; pfam13173 573413001280 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573413001281 PIN domain; Region: PIN_3; cl17397 573413001282 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573413001283 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413001284 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413001285 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 573413001286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413001287 Coenzyme A binding pocket [chemical binding]; other site 573413001288 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 573413001289 Fic family protein [Function unknown]; Region: COG3177 573413001290 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 573413001291 Fic/DOC family; Region: Fic; pfam02661 573413001292 Uncharacterized proteins similar to Bacteroides ovatus 4320; Region: Bacova_04320_like; cd12190 573413001293 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413001294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413001295 DNA-binding site [nucleotide binding]; DNA binding site 573413001296 FCD domain; Region: FCD; pfam07729 573413001297 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413001298 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413001299 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413001300 putative active site [active] 573413001301 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413001302 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413001303 inhibitor site; inhibition site 573413001304 active site 573413001305 dimer interface [polypeptide binding]; other site 573413001306 catalytic residue [active] 573413001307 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413001308 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413001309 substrate binding site [chemical binding]; other site 573413001310 ATP binding site [chemical binding]; other site 573413001311 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573413001312 classical (c) SDRs; Region: SDR_c; cd05233 573413001313 NAD(P) binding site [chemical binding]; other site 573413001314 active site 573413001315 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413001316 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413001317 NAD(P) binding site [chemical binding]; other site 573413001318 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413001319 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 573413001320 NAD binding site [chemical binding]; other site 573413001321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413001322 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413001323 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413001324 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413001325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413001326 DNA-binding site [nucleotide binding]; DNA binding site 573413001327 FCD domain; Region: FCD; pfam07729 573413001328 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 573413001329 Prominin; Region: Prominin; pfam05478 573413001330 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573413001331 MULE transposase domain; Region: MULE; pfam10551 573413001332 AAA domain; Region: AAA_14; pfam13173 573413001333 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 573413001334 putative transposase OrfB; Reviewed; Region: PHA02517 573413001335 HTH-like domain; Region: HTH_21; pfam13276 573413001336 Integrase core domain; Region: rve; pfam00665 573413001337 Integrase core domain; Region: rve_3; pfam13683 573413001338 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 573413001339 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 573413001340 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413001341 active site 573413001342 putative substrate binding pocket [chemical binding]; other site 573413001343 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 573413001344 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413001345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413001346 DNA-binding site [nucleotide binding]; DNA binding site 573413001347 UTRA domain; Region: UTRA; cl17743 573413001348 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413001349 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413001350 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 573413001351 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 573413001352 putative FMN binding site [chemical binding]; other site 573413001353 NADPH bind site [chemical binding]; other site 573413001354 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 573413001355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413001356 FeS/SAM binding site; other site 573413001357 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 573413001358 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573413001359 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573413001360 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573413001361 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 573413001362 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 573413001363 active site 573413001364 dimer interface [polypeptide binding]; other site 573413001365 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 573413001366 FMN binding site [chemical binding]; other site 573413001367 dimer interface [polypeptide binding]; other site 573413001368 MoxR-like ATPases [General function prediction only]; Region: COG0714 573413001369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413001370 Walker A motif; other site 573413001371 ATP binding site [chemical binding]; other site 573413001372 Walker B motif; other site 573413001373 arginine finger; other site 573413001374 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 573413001375 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573413001376 metal ion-dependent adhesion site (MIDAS); other site 573413001377 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 573413001378 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 573413001379 metal ion-dependent adhesion site (MIDAS); other site 573413001380 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573413001381 metal ion-dependent adhesion site (MIDAS); other site 573413001382 TPR repeat; Region: TPR_11; pfam13414 573413001383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413001384 TPR motif; other site 573413001385 binding surface 573413001386 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413001387 Oxygen tolerance; Region: BatD; pfam13584 573413001388 Smr domain; Region: Smr; pfam01713 573413001389 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573413001390 rRNA binding site [nucleotide binding]; other site 573413001391 predicted 30S ribosome binding site; other site 573413001392 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 573413001393 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 573413001394 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 573413001395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573413001396 ATP binding site [chemical binding]; other site 573413001397 putative Mg++ binding site [ion binding]; other site 573413001398 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 573413001399 RNA binding site [nucleotide binding]; other site 573413001400 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413001401 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413001402 ligand binding site [chemical binding]; other site 573413001403 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 573413001404 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 573413001405 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573413001406 Na binding site [ion binding]; other site 573413001407 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413001408 catalytic loop [active] 573413001409 iron binding site [ion binding]; other site 573413001410 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 573413001411 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413001412 4Fe-4S binding domain; Region: Fer4; pfam00037 573413001413 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413001414 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573413001415 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413001416 dimer interface [polypeptide binding]; other site 573413001417 [2Fe-2S] cluster binding site [ion binding]; other site 573413001418 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573413001419 SLBB domain; Region: SLBB; pfam10531 573413001420 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573413001421 putative oxidoreductase; Provisional; Region: PRK12831 573413001422 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413001423 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 573413001424 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573413001425 putative dimer interface [polypeptide binding]; other site 573413001426 [2Fe-2S] cluster binding site [ion binding]; other site 573413001427 PAS fold; Region: PAS; pfam00989 573413001428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413001429 putative active site [active] 573413001430 heme pocket [chemical binding]; other site 573413001431 GAF domain; Region: GAF_3; pfam13492 573413001432 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413001433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413001434 putative active site [active] 573413001435 heme pocket [chemical binding]; other site 573413001436 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413001437 dimer interface [polypeptide binding]; other site 573413001438 phosphorylation site [posttranslational modification] 573413001439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001440 ATP binding site [chemical binding]; other site 573413001441 Mg2+ binding site [ion binding]; other site 573413001442 G-X-G motif; other site 573413001443 Response regulator receiver domain; Region: Response_reg; pfam00072 573413001444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001445 active site 573413001446 phosphorylation site [posttranslational modification] 573413001447 intermolecular recognition site; other site 573413001448 dimerization interface [polypeptide binding]; other site 573413001449 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573413001450 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573413001451 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 573413001452 homodimer interface [polypeptide binding]; other site 573413001453 substrate-cofactor binding pocket; other site 573413001454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001455 catalytic residue [active] 573413001456 serine racemase; Region: PLN02970 573413001457 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573413001458 tetramer interface [polypeptide binding]; other site 573413001459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001460 catalytic residue [active] 573413001461 Sulphur transport; Region: Sulf_transp; pfam04143 573413001462 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 573413001463 CPxP motif; other site 573413001464 Sulphur transport; Region: Sulf_transp; pfam04143 573413001465 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573413001466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413001467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413001468 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573413001469 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573413001470 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573413001471 putative dimer interface [polypeptide binding]; other site 573413001472 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 573413001473 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573413001474 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573413001475 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413001476 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413001477 dimer interface [polypeptide binding]; other site 573413001478 putative CheW interface [polypeptide binding]; other site 573413001479 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573413001480 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573413001481 putative acyl-acceptor binding pocket; other site 573413001482 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573413001483 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573413001484 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 573413001485 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573413001486 active site 573413001487 metal binding site [ion binding]; metal-binding site 573413001488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413001489 dimerization interface [polypeptide binding]; other site 573413001490 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413001491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413001492 dimer interface [polypeptide binding]; other site 573413001493 putative CheW interface [polypeptide binding]; other site 573413001494 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 573413001495 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573413001496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001497 active site 573413001498 phosphorylation site [posttranslational modification] 573413001499 intermolecular recognition site; other site 573413001500 dimerization interface [polypeptide binding]; other site 573413001501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413001502 Walker A motif; other site 573413001503 ATP binding site [chemical binding]; other site 573413001504 Walker B motif; other site 573413001505 arginine finger; other site 573413001506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413001507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413001508 dimer interface [polypeptide binding]; other site 573413001509 phosphorylation site [posttranslational modification] 573413001510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001511 ATP binding site [chemical binding]; other site 573413001512 Mg2+ binding site [ion binding]; other site 573413001513 G-X-G motif; other site 573413001514 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 573413001515 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 573413001516 diiron binding motif [ion binding]; other site 573413001517 4Fe-4S binding domain; Region: Fer4_5; pfam12801 573413001518 4Fe-4S dicluster domain; Region: Fer4_18; pfam13746 573413001519 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413001520 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 573413001521 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573413001522 inhibitor-cofactor binding pocket; inhibition site 573413001523 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001524 catalytic residue [active] 573413001525 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573413001526 Peptidase family U32; Region: Peptidase_U32; pfam01136 573413001527 Peptidase family U32; Region: Peptidase_U32; cl03113 573413001528 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 573413001529 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 573413001530 TM-ABC transporter signature motif; other site 573413001531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413001532 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 573413001533 TM-ABC transporter signature motif; other site 573413001534 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413001535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413001536 Walker A/P-loop; other site 573413001537 ATP binding site [chemical binding]; other site 573413001538 Q-loop/lid; other site 573413001539 ABC transporter signature motif; other site 573413001540 Walker B; other site 573413001541 D-loop; other site 573413001542 H-loop/switch region; other site 573413001543 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413001544 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 573413001545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413001546 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573413001547 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573413001548 Bacterial transcriptional regulator; Region: IclR; pfam01614 573413001549 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 573413001550 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573413001551 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573413001552 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413001553 inhibitor site; inhibition site 573413001554 active site 573413001555 dimer interface [polypeptide binding]; other site 573413001556 catalytic residue [active] 573413001557 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413001558 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413001559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413001560 aspartate aminotransferase; Provisional; Region: PRK05764 573413001561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413001562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001563 homodimer interface [polypeptide binding]; other site 573413001564 catalytic residue [active] 573413001565 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573413001566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413001567 dimerization interface [polypeptide binding]; other site 573413001568 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413001569 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413001570 dimer interface [polypeptide binding]; other site 573413001571 putative CheW interface [polypeptide binding]; other site 573413001572 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573413001573 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413001574 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413001575 active site 573413001576 NAD binding site [chemical binding]; other site 573413001577 metal binding site [ion binding]; metal-binding site 573413001578 Protein of unknown function (DUF523); Region: DUF523; pfam04463 573413001579 Uncharacterized conserved protein [Function unknown]; Region: COG3272 573413001580 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 573413001581 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413001582 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413001583 DNA-binding site [nucleotide binding]; DNA binding site 573413001584 FCD domain; Region: FCD; pfam07729 573413001585 GAF domain; Region: GAF; cl17456 573413001586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413001587 metal binding site [ion binding]; metal-binding site 573413001588 active site 573413001589 I-site; other site 573413001590 SET domain; Region: SET; pfam00856 573413001591 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413001592 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413001593 Walker A/P-loop; other site 573413001594 ATP binding site [chemical binding]; other site 573413001595 Q-loop/lid; other site 573413001596 ABC transporter signature motif; other site 573413001597 Walker B; other site 573413001598 D-loop; other site 573413001599 H-loop/switch region; other site 573413001600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001601 dimer interface [polypeptide binding]; other site 573413001602 conserved gate region; other site 573413001603 putative PBP binding loops; other site 573413001604 ABC-ATPase subunit interface; other site 573413001605 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413001606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413001607 substrate binding pocket [chemical binding]; other site 573413001608 membrane-bound complex binding site; other site 573413001609 hinge residues; other site 573413001610 Cache domain; Region: Cache_1; pfam02743 573413001611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413001612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001613 ATP binding site [chemical binding]; other site 573413001614 Mg2+ binding site [ion binding]; other site 573413001615 G-X-G motif; other site 573413001616 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413001617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001618 active site 573413001619 phosphorylation site [posttranslational modification] 573413001620 intermolecular recognition site; other site 573413001621 dimerization interface [polypeptide binding]; other site 573413001622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413001623 DNA binding residues [nucleotide binding] 573413001624 dimerization interface [polypeptide binding]; other site 573413001625 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 573413001626 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 573413001627 drug efflux system protein MdtG; Provisional; Region: PRK09874 573413001628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413001629 putative substrate translocation pore; other site 573413001630 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 573413001631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573413001632 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 573413001633 diiron binding motif [ion binding]; other site 573413001634 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 573413001635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413001636 PAS domain; Region: PAS_9; pfam13426 573413001637 putative active site [active] 573413001638 heme pocket [chemical binding]; other site 573413001639 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413001640 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413001641 putative active site [active] 573413001642 heme pocket [chemical binding]; other site 573413001643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413001644 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413001645 putative active site [active] 573413001646 heme pocket [chemical binding]; other site 573413001647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413001648 dimer interface [polypeptide binding]; other site 573413001649 phosphorylation site [posttranslational modification] 573413001650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001651 ATP binding site [chemical binding]; other site 573413001652 Mg2+ binding site [ion binding]; other site 573413001653 G-X-G motif; other site 573413001654 serine/threonine protein kinase; Provisional; Region: PRK11768 573413001655 intracellular protease, PfpI family; Region: PfpI; TIGR01382 573413001656 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 573413001657 proposed catalytic triad [active] 573413001658 conserved cys residue [active] 573413001659 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413001660 EamA-like transporter family; Region: EamA; pfam00892 573413001661 EamA-like transporter family; Region: EamA; pfam00892 573413001662 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573413001663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413001664 Histidine kinase; Region: HisKA_2; pfam07568 573413001665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001666 ATP binding site [chemical binding]; other site 573413001667 Mg2+ binding site [ion binding]; other site 573413001668 G-X-G motif; other site 573413001669 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573413001670 synthetase active site [active] 573413001671 NTP binding site [chemical binding]; other site 573413001672 metal binding site [ion binding]; metal-binding site 573413001673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413001674 binding surface 573413001675 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413001676 TPR motif; other site 573413001677 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413001678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413001679 FeS/SAM binding site; other site 573413001680 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 573413001681 classical (c) SDRs; Region: SDR_c; cd05233 573413001682 NAD(P) binding site [chemical binding]; other site 573413001683 active site 573413001684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413001685 Histidine kinase; Region: HisKA_3; pfam07730 573413001686 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573413001687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413001688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001689 active site 573413001690 phosphorylation site [posttranslational modification] 573413001691 intermolecular recognition site; other site 573413001692 dimerization interface [polypeptide binding]; other site 573413001693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413001694 DNA binding residues [nucleotide binding] 573413001695 dimerization interface [polypeptide binding]; other site 573413001696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413001697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413001698 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001700 dimer interface [polypeptide binding]; other site 573413001701 conserved gate region; other site 573413001702 ABC-ATPase subunit interface; other site 573413001703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413001704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001705 dimer interface [polypeptide binding]; other site 573413001706 conserved gate region; other site 573413001707 putative PBP binding loops; other site 573413001708 ABC-ATPase subunit interface; other site 573413001709 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573413001710 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 573413001711 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573413001712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 573413001713 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 573413001714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 573413001715 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 573413001716 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 573413001717 Sporulation related domain; Region: SPOR; pfam05036 573413001718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413001719 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413001720 TM-ABC transporter signature motif; other site 573413001721 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413001722 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413001723 TM-ABC transporter signature motif; other site 573413001724 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413001725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413001726 Walker A/P-loop; other site 573413001727 ATP binding site [chemical binding]; other site 573413001728 Q-loop/lid; other site 573413001729 ABC transporter signature motif; other site 573413001730 Walker B; other site 573413001731 D-loop; other site 573413001732 H-loop/switch region; other site 573413001733 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413001734 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413001735 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413001736 phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK06827 573413001737 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573413001738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413001739 active site 573413001740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413001741 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413001742 nucleotide binding site [chemical binding]; other site 573413001743 Protein of unknown function DUF45; Region: DUF45; pfam01863 573413001744 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573413001745 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573413001746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413001747 putative DNA binding site [nucleotide binding]; other site 573413001748 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573413001749 putative Zn2+ binding site [ion binding]; other site 573413001750 Bacterial transcriptional regulator; Region: IclR; pfam01614 573413001751 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573413001752 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573413001753 Bacterial transcriptional regulator; Region: IclR; pfam01614 573413001754 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 573413001755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573413001756 inhibitor-cofactor binding pocket; inhibition site 573413001757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001758 catalytic residue [active] 573413001759 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573413001760 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573413001761 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413001762 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 573413001763 metal binding site [ion binding]; metal-binding site 573413001764 dimer interface [polypeptide binding]; other site 573413001765 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413001766 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573413001767 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 573413001768 DctM-like transporters; Region: DctM; pfam06808 573413001769 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573413001770 hypothetical protein; Provisional; Region: PRK07475 573413001771 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 573413001772 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573413001773 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 573413001774 active site 573413001775 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573413001776 tetramer interface [polypeptide binding]; other site 573413001777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413001778 catalytic residue [active] 573413001779 ectoine utilization protein EutC; Validated; Region: PRK08291 573413001780 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 573413001781 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 573413001782 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 573413001783 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 573413001784 active site 573413001785 aspartate kinase; Reviewed; Region: PRK09034 573413001786 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573413001787 nucleotide binding site [chemical binding]; other site 573413001788 substrate binding site [chemical binding]; other site 573413001789 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573413001790 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573413001791 HD supefamily hydrolase [General function prediction only]; Region: COG3294 573413001792 PilZ domain; Region: PilZ; pfam07238 573413001793 CheD chemotactic sensory transduction; Region: CheD; cl00810 573413001794 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573413001795 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573413001796 Walker A/P-loop; other site 573413001797 ATP binding site [chemical binding]; other site 573413001798 Q-loop/lid; other site 573413001799 ABC transporter signature motif; other site 573413001800 Walker B; other site 573413001801 D-loop; other site 573413001802 H-loop/switch region; other site 573413001803 TOBE domain; Region: TOBE; pfam03459 573413001804 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 573413001805 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 573413001806 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573413001807 DNA binding site [nucleotide binding] 573413001808 active site 573413001809 Uncharacterized conserved protein [Function unknown]; Region: COG1432 573413001810 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 573413001811 putative metal binding site [ion binding]; other site 573413001812 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 573413001813 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 573413001814 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 573413001815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573413001816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413001817 S-adenosylmethionine binding site [chemical binding]; other site 573413001818 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 573413001819 dimer interface [polypeptide binding]; other site 573413001820 catalytic triad [active] 573413001821 peroxidatic and resolving cysteines [active] 573413001822 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 573413001823 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 573413001824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413001825 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573413001826 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 573413001827 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573413001828 E3 interaction surface; other site 573413001829 lipoyl attachment site [posttranslational modification]; other site 573413001830 e3 binding domain; Region: E3_binding; pfam02817 573413001831 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 573413001832 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 573413001833 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 573413001834 alpha subunit interface [polypeptide binding]; other site 573413001835 TPP binding site [chemical binding]; other site 573413001836 heterodimer interface [polypeptide binding]; other site 573413001837 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413001838 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 573413001839 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 573413001840 tetramer interface [polypeptide binding]; other site 573413001841 TPP-binding site [chemical binding]; other site 573413001842 heterodimer interface [polypeptide binding]; other site 573413001843 phosphorylation loop region [posttranslational modification] 573413001844 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573413001845 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573413001846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413001847 non-specific DNA binding site [nucleotide binding]; other site 573413001848 salt bridge; other site 573413001849 sequence-specific DNA binding site [nucleotide binding]; other site 573413001850 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 573413001851 FMN-binding domain; Region: FMN_bind; cl01081 573413001852 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 573413001853 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 573413001854 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 573413001855 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413001856 catalytic loop [active] 573413001857 iron binding site [ion binding]; other site 573413001858 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573413001859 FAD binding pocket [chemical binding]; other site 573413001860 conserved FAD binding motif [chemical binding]; other site 573413001861 phosphate binding motif [ion binding]; other site 573413001862 beta-alpha-beta structure motif; other site 573413001863 NAD binding pocket [chemical binding]; other site 573413001864 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 573413001865 DNA-binding interface [nucleotide binding]; DNA binding site 573413001866 WYL domain; Region: WYL; pfam13280 573413001867 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 573413001868 Rubrerythrin [Energy production and conversion]; Region: COG1592 573413001869 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 573413001870 binuclear metal center [ion binding]; other site 573413001871 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 573413001872 iron binding site [ion binding]; other site 573413001873 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 573413001874 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 573413001875 non-heme iron binding site [ion binding]; other site 573413001876 dimer interface [polypeptide binding]; other site 573413001877 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 573413001878 non-heme iron binding site [ion binding]; other site 573413001879 dimer interface [polypeptide binding]; other site 573413001880 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 573413001881 Ferritin-like domain; Region: Ferritin; pfam00210 573413001882 ferroxidase diiron center [ion binding]; other site 573413001883 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 573413001884 Rubredoxin; Region: Rubredoxin; pfam00301 573413001885 iron binding site [ion binding]; other site 573413001886 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413001887 FeS/SAM binding site; other site 573413001888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 573413001889 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 573413001890 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 573413001891 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 573413001892 substrate binding pocket [chemical binding]; other site 573413001893 dimer interface [polypeptide binding]; other site 573413001894 inhibitor binding site; inhibition site 573413001895 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573413001896 B12 binding site [chemical binding]; other site 573413001897 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 573413001898 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 573413001899 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413001900 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 573413001901 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573413001902 dimer interface [polypeptide binding]; other site 573413001903 PYR/PP interface [polypeptide binding]; other site 573413001904 TPP binding site [chemical binding]; other site 573413001905 substrate binding site [chemical binding]; other site 573413001906 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413001907 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 573413001908 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 573413001909 TPP-binding site [chemical binding]; other site 573413001910 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573413001911 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 573413001912 Fasciclin domain; Region: Fasciclin; pfam02469 573413001913 ABC transporter ATPase component; Reviewed; Region: PRK11147 573413001914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413001915 ABC transporter; Region: ABC_tran_2; pfam12848 573413001916 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413001917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573413001918 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 573413001919 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573413001920 dimer interface [polypeptide binding]; other site 573413001921 PYR/PP interface [polypeptide binding]; other site 573413001922 TPP binding site [chemical binding]; other site 573413001923 substrate binding site [chemical binding]; other site 573413001924 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 573413001925 Domain of unknown function; Region: EKR; pfam10371 573413001926 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573413001927 4Fe-4S binding domain; Region: Fer4; pfam00037 573413001928 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 573413001929 TPP-binding site [chemical binding]; other site 573413001930 dimer interface [polypeptide binding]; other site 573413001931 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573413001932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413001933 dimerization interface [polypeptide binding]; other site 573413001934 Histidine kinase; Region: His_kinase; pfam06580 573413001935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413001936 ATP binding site [chemical binding]; other site 573413001937 Mg2+ binding site [ion binding]; other site 573413001938 G-X-G motif; other site 573413001939 Response regulator receiver domain; Region: Response_reg; pfam00072 573413001940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413001941 active site 573413001942 phosphorylation site [posttranslational modification] 573413001943 intermolecular recognition site; other site 573413001944 dimerization interface [polypeptide binding]; other site 573413001945 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573413001946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413001947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001948 dimer interface [polypeptide binding]; other site 573413001949 putative PBP binding loops; other site 573413001950 ABC-ATPase subunit interface; other site 573413001951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001952 dimer interface [polypeptide binding]; other site 573413001953 conserved gate region; other site 573413001954 putative PBP binding loops; other site 573413001955 ABC-ATPase subunit interface; other site 573413001956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413001957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413001958 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 573413001959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573413001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413001961 Coenzyme A binding pocket [chemical binding]; other site 573413001962 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413001963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413001964 DNA-binding site [nucleotide binding]; DNA binding site 573413001965 UTRA domain; Region: UTRA; pfam07702 573413001966 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 573413001967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573413001968 active site 573413001969 metal binding site [ion binding]; metal-binding site 573413001970 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573413001971 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413001972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001973 dimer interface [polypeptide binding]; other site 573413001974 conserved gate region; other site 573413001975 putative PBP binding loops; other site 573413001976 ABC-ATPase subunit interface; other site 573413001977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413001978 dimer interface [polypeptide binding]; other site 573413001979 conserved gate region; other site 573413001980 putative PBP binding loops; other site 573413001981 ABC-ATPase subunit interface; other site 573413001982 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413001983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413001984 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 573413001985 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 573413001986 active site 573413001987 homodimer interface [polypeptide binding]; other site 573413001988 catalytic site [active] 573413001989 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573413001990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413001991 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573413001992 dimer interface [polypeptide binding]; other site 573413001993 ADP-ribose binding site [chemical binding]; other site 573413001994 active site 573413001995 nudix motif; other site 573413001996 metal binding site [ion binding]; metal-binding site 573413001997 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 573413001998 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 573413001999 putative active site [active] 573413002000 FecR protein; Region: FecR; pfam04773 573413002001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413002002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413002003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573413002004 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 573413002005 Sulfatase; Region: Sulfatase; cl17466 573413002006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413002007 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413002008 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413002009 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 573413002010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413002011 FeS/SAM binding site; other site 573413002012 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573413002013 Domain of unknown function (DUF202); Region: DUF202; pfam02656 573413002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413002016 active site 573413002017 phosphorylation site [posttranslational modification] 573413002018 intermolecular recognition site; other site 573413002019 dimerization interface [polypeptide binding]; other site 573413002020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413002021 DNA binding site [nucleotide binding] 573413002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413002023 dimer interface [polypeptide binding]; other site 573413002024 phosphorylation site [posttranslational modification] 573413002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413002026 ATP binding site [chemical binding]; other site 573413002027 Mg2+ binding site [ion binding]; other site 573413002028 G-X-G motif; other site 573413002029 Response regulator receiver domain; Region: Response_reg; pfam00072 573413002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413002031 active site 573413002032 phosphorylation site [posttranslational modification] 573413002033 intermolecular recognition site; other site 573413002034 dimerization interface [polypeptide binding]; other site 573413002035 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573413002036 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 573413002037 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413002038 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413002039 Uncharacterized conserved protein [Function unknown]; Region: COG1262 573413002040 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 573413002041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413002042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413002043 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 573413002044 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573413002045 putative acetyltransferase; Provisional; Region: PRK03624 573413002046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413002047 Coenzyme A binding pocket [chemical binding]; other site 573413002048 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573413002049 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573413002050 active site 573413002051 metal binding site [ion binding]; metal-binding site 573413002052 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413002053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413002054 dimer interface [polypeptide binding]; other site 573413002055 putative CheW interface [polypeptide binding]; other site 573413002056 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 573413002057 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 573413002058 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 573413002059 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 573413002060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413002061 UDP-galactopyranose mutase; Region: GLF; pfam03275 573413002062 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573413002063 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573413002064 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573413002065 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573413002066 Walker A/P-loop; other site 573413002067 ATP binding site [chemical binding]; other site 573413002068 Q-loop/lid; other site 573413002069 ABC transporter signature motif; other site 573413002070 Walker B; other site 573413002071 D-loop; other site 573413002072 H-loop/switch region; other site 573413002073 Rhamnan synthesis protein F; Region: RgpF; pfam05045 573413002074 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413002075 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 573413002076 active site 573413002077 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413002078 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413002079 active site 573413002080 Methyltransferase domain; Region: Methyltransf_24; pfam13578 573413002081 Tropomyosin; Region: Tropomyosin; pfam00261 573413002082 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 573413002083 linker region; other site 573413002084 Rhamnan synthesis protein F; Region: RgpF; pfam05045 573413002085 Protein of unknown function (DUF616); Region: DUF616; pfam04765 573413002086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413002087 active site 573413002088 Uncharacterized conserved protein [Function unknown]; Region: COG5663 573413002089 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 573413002090 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573413002091 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573413002092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573413002093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413002094 NAD(P) binding site [chemical binding]; other site 573413002095 active site 573413002096 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573413002097 Ligand binding site; other site 573413002098 Putative Catalytic site; other site 573413002099 DXD motif; other site 573413002100 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413002101 FeS/SAM binding site; other site 573413002102 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 573413002103 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573413002104 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573413002105 substrate binding site; other site 573413002106 tetramer interface; other site 573413002107 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573413002108 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573413002109 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573413002110 NADP binding site [chemical binding]; other site 573413002111 active site 573413002112 putative substrate binding site [chemical binding]; other site 573413002113 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573413002114 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573413002115 NAD binding site [chemical binding]; other site 573413002116 substrate binding site [chemical binding]; other site 573413002117 homodimer interface [polypeptide binding]; other site 573413002118 active site 573413002119 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573413002120 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413002121 active site 573413002122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413002123 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573413002124 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413002125 active site 573413002126 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413002127 active site 573413002128 Phage Tail Collar Domain; Region: Collar; pfam07484 573413002129 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573413002130 active site 573413002131 catalytic site [active] 573413002132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 573413002133 Homeodomain-like domain; Region: HTH_32; pfam13565 573413002134 Integrase core domain; Region: rve; pfam00665 573413002135 Integrase core domain; Region: rve_3; pfam13683 573413002136 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 573413002137 dimerization interface [polypeptide binding]; other site 573413002138 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 573413002139 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 573413002140 putative sugar binding sites [chemical binding]; other site 573413002141 Q-X-W motif; other site 573413002142 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413002143 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 573413002144 putative active site [active] 573413002145 homotetrameric interface [polypeptide binding]; other site 573413002146 metal binding site [ion binding]; metal-binding site 573413002147 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413002148 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573413002149 active site 573413002150 NTP binding site [chemical binding]; other site 573413002151 metal binding triad [ion binding]; metal-binding site 573413002152 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 573413002153 PemK-like protein; Region: PemK; pfam02452 573413002154 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 573413002155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002157 DNA binding site [nucleotide binding] 573413002158 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413002159 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413002160 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413002161 ligand binding site [chemical binding]; other site 573413002162 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413002163 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413002164 Walker A/P-loop; other site 573413002165 ATP binding site [chemical binding]; other site 573413002166 Q-loop/lid; other site 573413002167 ABC transporter signature motif; other site 573413002168 Walker B; other site 573413002169 D-loop; other site 573413002170 H-loop/switch region; other site 573413002171 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413002172 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002173 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413002174 TM-ABC transporter signature motif; other site 573413002175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413002176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413002177 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413002178 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413002179 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 573413002180 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 573413002181 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573413002182 putative glycosyl transferase; Provisional; Region: PRK10073 573413002183 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413002184 active site 573413002185 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413002186 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413002187 active site 573413002188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413002189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573413002190 Walker A/P-loop; other site 573413002191 ATP binding site [chemical binding]; other site 573413002192 Q-loop/lid; other site 573413002193 ABC transporter signature motif; other site 573413002194 Walker B; other site 573413002195 D-loop; other site 573413002196 H-loop/switch region; other site 573413002197 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573413002198 FtsX-like permease family; Region: FtsX; pfam02687 573413002199 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573413002200 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413002201 FtsX-like permease family; Region: FtsX; pfam02687 573413002202 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413002203 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413002204 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413002205 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002206 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413002207 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 573413002208 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002210 dimer interface [polypeptide binding]; other site 573413002211 conserved gate region; other site 573413002212 putative PBP binding loops; other site 573413002213 ABC-ATPase subunit interface; other site 573413002214 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573413002215 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 573413002216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413002217 motif II; other site 573413002218 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573413002219 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573413002220 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413002221 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413002222 ligand binding site [chemical binding]; other site 573413002223 flexible hinge region; other site 573413002224 AAA ATPase domain; Region: AAA_16; pfam13191 573413002225 Archaeal ATPase; Region: Arch_ATPase; pfam01637 573413002226 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 573413002227 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413002228 dimer interface [polypeptide binding]; other site 573413002229 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573413002230 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 573413002231 putative PBP binding regions; other site 573413002232 ABC-ATPase subunit interface; other site 573413002233 Domain of unknown function (DUF1893); Region: TM1506; pfam08973 573413002234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413002235 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 573413002236 Walker A/P-loop; other site 573413002237 ATP binding site [chemical binding]; other site 573413002238 Q-loop/lid; other site 573413002239 ABC transporter signature motif; other site 573413002240 Walker B; other site 573413002241 D-loop; other site 573413002242 H-loop/switch region; other site 573413002243 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 573413002244 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 573413002245 dimerization interface [polypeptide binding]; other site 573413002246 putative active cleft [active] 573413002247 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002248 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413002249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002250 dimer interface [polypeptide binding]; other site 573413002251 conserved gate region; other site 573413002252 putative PBP binding loops; other site 573413002253 ABC-ATPase subunit interface; other site 573413002254 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002256 dimer interface [polypeptide binding]; other site 573413002257 conserved gate region; other site 573413002258 putative PBP binding loops; other site 573413002259 ABC-ATPase subunit interface; other site 573413002260 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413002261 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413002262 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413002263 FGGY family of carbohydrate kinases; Region: FGGY; cd00366 573413002264 N- and C-terminal domain interface [polypeptide binding]; other site 573413002265 active site 573413002266 MgATP binding site [chemical binding]; other site 573413002267 catalytic site [active] 573413002268 metal binding site [ion binding]; metal-binding site 573413002269 carbohydrate binding site [chemical binding]; other site 573413002270 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413002271 intersubunit interface [polypeptide binding]; other site 573413002272 active site 573413002273 zinc binding site [ion binding]; other site 573413002274 Na+ binding site [ion binding]; other site 573413002275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002276 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413002277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002278 putative PBP binding loops; other site 573413002279 ABC-ATPase subunit interface; other site 573413002280 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002282 dimer interface [polypeptide binding]; other site 573413002283 conserved gate region; other site 573413002284 putative PBP binding loops; other site 573413002285 ABC-ATPase subunit interface; other site 573413002286 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413002287 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413002288 substrate binding site [chemical binding]; other site 573413002289 ATP binding site [chemical binding]; other site 573413002290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413002291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413002292 active site 573413002293 phosphorylation site [posttranslational modification] 573413002294 intermolecular recognition site; other site 573413002295 dimerization interface [polypeptide binding]; other site 573413002296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413002297 DNA binding residues [nucleotide binding] 573413002298 dimerization interface [polypeptide binding]; other site 573413002299 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 573413002300 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 573413002301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413002302 non-specific DNA binding site [nucleotide binding]; other site 573413002303 salt bridge; other site 573413002304 sequence-specific DNA binding site [nucleotide binding]; other site 573413002305 Cupin domain; Region: Cupin_2; pfam07883 573413002306 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 573413002307 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413002308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413002309 NAD(P) binding site [chemical binding]; other site 573413002310 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573413002311 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413002312 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413002313 NAD(P) binding site [chemical binding]; other site 573413002314 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413002315 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413002316 Metal-binding active site; metal-binding site 573413002317 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413002318 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 573413002319 putative ligand binding site [chemical binding]; other site 573413002320 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573413002321 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413002322 Walker A/P-loop; other site 573413002323 ATP binding site [chemical binding]; other site 573413002324 Q-loop/lid; other site 573413002325 ABC transporter signature motif; other site 573413002326 Walker B; other site 573413002327 D-loop; other site 573413002328 H-loop/switch region; other site 573413002329 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413002330 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002331 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413002332 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573413002333 TM-ABC transporter signature motif; other site 573413002334 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413002335 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413002336 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413002337 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413002338 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 573413002339 Fic family protein [Function unknown]; Region: COG3177 573413002340 Fic/DOC family; Region: Fic; pfam02661 573413002341 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413002342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413002343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413002344 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 573413002345 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413002346 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413002347 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573413002348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413002349 motif II; other site 573413002350 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573413002351 thiamine phosphate binding site [chemical binding]; other site 573413002352 active site 573413002353 pyrophosphate binding site [ion binding]; other site 573413002354 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 573413002355 substrate binding site [chemical binding]; other site 573413002356 multimerization interface [polypeptide binding]; other site 573413002357 ATP binding site [chemical binding]; other site 573413002358 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573413002359 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573413002360 substrate binding site [chemical binding]; other site 573413002361 dimer interface [polypeptide binding]; other site 573413002362 ATP binding site [chemical binding]; other site 573413002363 fructoselysine 3-epimerase; Provisional; Region: PRK09856 573413002364 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413002365 Methyltransferase domain; Region: Methyltransf_32; pfam13679 573413002366 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 573413002367 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 573413002368 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413002369 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413002370 metal binding site [ion binding]; metal-binding site 573413002371 active site 573413002372 I-site; other site 573413002373 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413002374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413002375 S-adenosylmethionine binding site [chemical binding]; other site 573413002376 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 573413002377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413002378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413002379 DNA binding residues [nucleotide binding] 573413002380 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413002381 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413002382 inhibitor site; inhibition site 573413002383 active site 573413002384 dimer interface [polypeptide binding]; other site 573413002385 catalytic residue [active] 573413002386 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 573413002387 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573413002388 NADP binding site [chemical binding]; other site 573413002389 homodimer interface [polypeptide binding]; other site 573413002390 active site 573413002391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413002392 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413002393 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413002394 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413002395 AP (apurinic/apyrimidinic) site pocket; other site 573413002396 DNA interaction; other site 573413002397 Metal-binding active site; metal-binding site 573413002398 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 573413002399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413002400 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413002401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 573413002402 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 573413002403 HIT family signature motif; other site 573413002404 catalytic residue [active] 573413002405 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 573413002406 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413002407 putative ligand binding site [chemical binding]; other site 573413002408 putative NAD binding site [chemical binding]; other site 573413002409 catalytic site [active] 573413002410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002412 DNA binding site [nucleotide binding] 573413002413 domain linker motif; other site 573413002414 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002415 dimerization interface [polypeptide binding]; other site 573413002416 ligand binding site [chemical binding]; other site 573413002417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413002418 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413002419 substrate binding site [chemical binding]; other site 573413002420 ATP binding site [chemical binding]; other site 573413002421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002423 DNA binding site [nucleotide binding] 573413002424 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002425 dimerization interface [polypeptide binding]; other site 573413002426 ligand binding site [chemical binding]; other site 573413002427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002429 dimer interface [polypeptide binding]; other site 573413002430 conserved gate region; other site 573413002431 putative PBP binding loops; other site 573413002432 ABC-ATPase subunit interface; other site 573413002433 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573413002434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002435 dimer interface [polypeptide binding]; other site 573413002436 conserved gate region; other site 573413002437 putative PBP binding loops; other site 573413002438 ABC-ATPase subunit interface; other site 573413002439 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 573413002440 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 573413002441 NAD(P) binding site [chemical binding]; other site 573413002442 LDH/MDH dimer interface [polypeptide binding]; other site 573413002443 substrate binding site [chemical binding]; other site 573413002444 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 573413002445 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413002446 ATP binding site [chemical binding]; other site 573413002447 substrate binding site [chemical binding]; other site 573413002448 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002449 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413002450 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002451 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002452 DNA binding site [nucleotide binding] 573413002453 domain linker motif; other site 573413002454 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002455 dimerization interface [polypeptide binding]; other site 573413002456 ligand binding site [chemical binding]; other site 573413002457 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 573413002458 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 573413002459 NAD(P) binding site [chemical binding]; other site 573413002460 catalytic residues [active] 573413002461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002462 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002463 ligand binding site [chemical binding]; other site 573413002464 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413002465 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413002466 DNA-binding site [nucleotide binding]; DNA binding site 573413002467 FCD domain; Region: FCD; pfam07729 573413002468 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413002469 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573413002470 dimer interface [polypeptide binding]; other site 573413002471 active site 573413002472 catalytic residue [active] 573413002473 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413002474 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413002475 inhibitor site; inhibition site 573413002476 active site 573413002477 dimer interface [polypeptide binding]; other site 573413002478 catalytic residue [active] 573413002479 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413002480 substrate binding pocket [chemical binding]; other site 573413002481 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413002482 membrane-bound complex binding site; other site 573413002483 hinge residues; other site 573413002484 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413002485 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413002486 Walker A/P-loop; other site 573413002487 ATP binding site [chemical binding]; other site 573413002488 Q-loop/lid; other site 573413002489 ABC transporter signature motif; other site 573413002490 Walker B; other site 573413002491 D-loop; other site 573413002492 H-loop/switch region; other site 573413002493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002494 dimer interface [polypeptide binding]; other site 573413002495 conserved gate region; other site 573413002496 putative PBP binding loops; other site 573413002497 ABC-ATPase subunit interface; other site 573413002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002499 dimer interface [polypeptide binding]; other site 573413002500 conserved gate region; other site 573413002501 putative PBP binding loops; other site 573413002502 ABC-ATPase subunit interface; other site 573413002503 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573413002504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413002505 catalytic residue [active] 573413002506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413002507 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573413002508 substrate binding site [chemical binding]; other site 573413002509 dimer interface [polypeptide binding]; other site 573413002510 ATP binding site [chemical binding]; other site 573413002511 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573413002512 putative active site [active] 573413002513 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 573413002514 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573413002515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413002516 DNA-binding site [nucleotide binding]; DNA binding site 573413002517 FCD domain; Region: FCD; pfam07729 573413002518 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413002519 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413002520 inhibitor site; inhibition site 573413002521 active site 573413002522 dimer interface [polypeptide binding]; other site 573413002523 catalytic residue [active] 573413002524 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002525 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002527 dimer interface [polypeptide binding]; other site 573413002528 conserved gate region; other site 573413002529 putative PBP binding loops; other site 573413002530 ABC-ATPase subunit interface; other site 573413002531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573413002533 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 573413002534 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 573413002535 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 573413002536 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 573413002537 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 573413002538 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413002539 AAA domain; Region: AAA_33; pfam13671 573413002540 AAA domain; Region: AAA_17; pfam13207 573413002541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002542 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413002543 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002545 putative PBP binding loops; other site 573413002546 ABC-ATPase subunit interface; other site 573413002547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002549 dimer interface [polypeptide binding]; other site 573413002550 conserved gate region; other site 573413002551 ABC-ATPase subunit interface; other site 573413002552 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573413002553 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573413002554 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 573413002555 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 573413002556 putative substrate binding site [chemical binding]; other site 573413002557 putative ATP binding site [chemical binding]; other site 573413002558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413002559 L-fuculokinase; Region: fuculo_kin_coli; TIGR02628 573413002560 nucleotide binding site [chemical binding]; other site 573413002561 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413002562 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413002563 intersubunit interface [polypeptide binding]; other site 573413002564 active site 573413002565 zinc binding site [ion binding]; other site 573413002566 Na+ binding site [ion binding]; other site 573413002567 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413002568 intersubunit interface [polypeptide binding]; other site 573413002569 active site 573413002570 zinc binding site [ion binding]; other site 573413002571 Na+ binding site [ion binding]; other site 573413002572 D-allose kinase; Provisional; Region: PRK09698 573413002573 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413002574 Predicted kinase [General function prediction only]; Region: COG0645 573413002575 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573413002576 active site 573413002577 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 573413002578 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573413002579 substrate binding site [chemical binding]; other site 573413002580 hexamer interface [polypeptide binding]; other site 573413002581 metal binding site [ion binding]; metal-binding site 573413002582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413002583 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 573413002584 putative ligand binding site [chemical binding]; other site 573413002585 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002586 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413002587 TM-ABC transporter signature motif; other site 573413002588 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413002589 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413002590 Walker A/P-loop; other site 573413002591 ATP binding site [chemical binding]; other site 573413002592 Q-loop/lid; other site 573413002593 ABC transporter signature motif; other site 573413002594 Walker B; other site 573413002595 D-loop; other site 573413002596 H-loop/switch region; other site 573413002597 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413002598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413002599 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413002600 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413002601 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 573413002602 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 573413002603 active site pocket [active] 573413002604 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 573413002605 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 573413002606 active site 573413002607 metal binding site [ion binding]; metal-binding site 573413002608 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413002609 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413002610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413002611 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 573413002612 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573413002613 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573413002614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413002615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413002616 DNA-binding site [nucleotide binding]; DNA binding site 573413002617 FCD domain; Region: FCD; pfam07729 573413002618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413002619 DNA-binding site [nucleotide binding]; DNA binding site 573413002620 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413002621 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 573413002622 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413002623 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413002624 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413002625 ligand binding site [chemical binding]; other site 573413002626 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002627 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413002628 TM-ABC transporter signature motif; other site 573413002629 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413002630 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413002631 Walker A/P-loop; other site 573413002632 ATP binding site [chemical binding]; other site 573413002633 Q-loop/lid; other site 573413002634 ABC transporter signature motif; other site 573413002635 Walker B; other site 573413002636 D-loop; other site 573413002637 H-loop/switch region; other site 573413002638 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413002639 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 573413002640 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413002641 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002642 TM-ABC transporter signature motif; other site 573413002643 alpha-galactosidase; Provisional; Region: PRK15076 573413002644 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 573413002645 NAD(P) binding site [chemical binding]; other site 573413002646 LDH/MDH dimer interface [polypeptide binding]; other site 573413002647 substrate binding site [chemical binding]; other site 573413002648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002650 dimer interface [polypeptide binding]; other site 573413002651 conserved gate region; other site 573413002652 putative PBP binding loops; other site 573413002653 ABC-ATPase subunit interface; other site 573413002654 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002656 dimer interface [polypeptide binding]; other site 573413002657 ABC-ATPase subunit interface; other site 573413002658 putative PBP binding loops; other site 573413002659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413002661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002663 DNA binding site [nucleotide binding] 573413002664 domain linker motif; other site 573413002665 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002666 ligand binding site [chemical binding]; other site 573413002667 dimerization interface [polypeptide binding]; other site 573413002668 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413002669 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 573413002670 ligand binding site [chemical binding]; other site 573413002671 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413002672 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413002673 Walker A/P-loop; other site 573413002674 ATP binding site [chemical binding]; other site 573413002675 Q-loop/lid; other site 573413002676 ABC transporter signature motif; other site 573413002677 Walker B; other site 573413002678 D-loop; other site 573413002679 H-loop/switch region; other site 573413002680 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413002681 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002682 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413002683 TM-ABC transporter signature motif; other site 573413002684 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413002685 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413002686 TM-ABC transporter signature motif; other site 573413002687 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 573413002688 active site 573413002689 tetramer interface [polypeptide binding]; other site 573413002690 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 573413002691 homodimer interface [polypeptide binding]; other site 573413002692 homotetramer interface [polypeptide binding]; other site 573413002693 active site pocket [active] 573413002694 cleavage site 573413002695 FMN-binding domain; Region: FMN_bind; cl01081 573413002696 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413002697 L-aspartate oxidase; Provisional; Region: PRK06175 573413002698 Predicted oxidoreductase [General function prediction only]; Region: COG3573 573413002699 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573413002700 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 573413002701 DNA binding residues [nucleotide binding] 573413002702 dimer interface [polypeptide binding]; other site 573413002703 FMN-binding domain; Region: FMN_bind; cl01081 573413002704 FAD binding domain; Region: FAD_binding_2; pfam00890 573413002705 L-aspartate oxidase; Provisional; Region: PRK06175 573413002706 FMN-binding domain; Region: FMN_bind; cl01081 573413002707 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413002708 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413002709 PAS domain; Region: PAS_9; pfam13426 573413002710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413002711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413002712 metal binding site [ion binding]; metal-binding site 573413002713 active site 573413002714 I-site; other site 573413002715 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 573413002716 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 573413002717 dimer interface [polypeptide binding]; other site 573413002718 active site 573413002719 metal binding site [ion binding]; metal-binding site 573413002720 Cache domain; Region: Cache_1; pfam02743 573413002721 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413002722 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413002723 metal binding site [ion binding]; metal-binding site 573413002724 active site 573413002725 I-site; other site 573413002726 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413002727 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 573413002728 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573413002729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413002730 ATP binding site [chemical binding]; other site 573413002731 ATP binding site [chemical binding]; other site 573413002732 putative Mg++ binding site [ion binding]; other site 573413002733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413002734 nucleotide binding region [chemical binding]; other site 573413002735 ATP-binding site [chemical binding]; other site 573413002736 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 573413002737 HRDC domain; Region: HRDC; pfam00570 573413002738 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 573413002739 putative active site [active] 573413002740 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573413002741 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573413002742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413002743 DNA-binding site [nucleotide binding]; DNA binding site 573413002744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413002745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413002746 homodimer interface [polypeptide binding]; other site 573413002747 catalytic residue [active] 573413002748 FMN-binding domain; Region: FMN_bind; cl01081 573413002749 FMN-binding domain; Region: FMN_bind; pfam04205 573413002750 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413002751 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 573413002752 Predicted oxidoreductase [General function prediction only]; Region: COG3573 573413002753 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413002754 active site 573413002755 metal binding site [ion binding]; metal-binding site 573413002756 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 573413002757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413002758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413002759 DNA binding residues [nucleotide binding] 573413002760 dimerization interface [polypeptide binding]; other site 573413002761 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573413002762 B12 binding site [chemical binding]; other site 573413002763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413002764 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573413002765 FeS/SAM binding site; other site 573413002766 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573413002767 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573413002768 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573413002769 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 573413002770 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573413002771 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573413002772 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 573413002773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413002774 active site 573413002775 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413002776 substrate binding site [chemical binding]; other site 573413002777 ATP binding site [chemical binding]; other site 573413002778 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 573413002779 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 573413002780 GTP binding site; other site 573413002781 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 573413002782 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573413002783 DHHA1 domain; Region: DHHA1; pfam02272 573413002784 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413002785 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413002786 dimer interface [polypeptide binding]; other site 573413002787 putative CheW interface [polypeptide binding]; other site 573413002788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413002789 PAS fold; Region: PAS_3; pfam08447 573413002790 putative active site [active] 573413002791 heme pocket [chemical binding]; other site 573413002792 PAS domain S-box; Region: sensory_box; TIGR00229 573413002793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413002794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413002795 ATP binding site [chemical binding]; other site 573413002796 Mg2+ binding site [ion binding]; other site 573413002797 G-X-G motif; other site 573413002798 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 573413002799 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573413002800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413002801 catalytic residue [active] 573413002802 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 573413002803 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 573413002804 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573413002805 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 573413002806 putative NAD(P) binding site [chemical binding]; other site 573413002807 active site 573413002808 Predicted transcriptional regulator [Transcription]; Region: COG2345 573413002809 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413002810 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413002811 metal binding site [ion binding]; metal-binding site 573413002812 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 573413002813 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 573413002814 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 573413002815 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 573413002816 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 573413002817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002819 DNA binding site [nucleotide binding] 573413002820 domain linker motif; other site 573413002821 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002822 ligand binding site [chemical binding]; other site 573413002823 dimerization interface [polypeptide binding]; other site 573413002824 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 573413002825 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 573413002826 Ligand Binding Site [chemical binding]; other site 573413002827 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 573413002828 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573413002829 active site 573413002830 interdomain interaction site; other site 573413002831 putative metal-binding site [ion binding]; other site 573413002832 nucleotide binding site [chemical binding]; other site 573413002833 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 573413002834 domain I; other site 573413002835 phosphate binding site [ion binding]; other site 573413002836 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573413002837 domain II; other site 573413002838 domain III; other site 573413002839 nucleotide binding site [chemical binding]; other site 573413002840 DNA binding groove [nucleotide binding] 573413002841 catalytic site [active] 573413002842 domain IV; other site 573413002843 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573413002844 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573413002845 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573413002846 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 573413002847 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573413002848 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573413002849 nucleophilic elbow; other site 573413002850 catalytic triad; other site 573413002851 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 573413002852 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 573413002853 Walker A/P-loop; other site 573413002854 ATP binding site [chemical binding]; other site 573413002855 Q-loop/lid; other site 573413002856 ABC transporter signature motif; other site 573413002857 Walker B; other site 573413002858 D-loop; other site 573413002859 H-loop/switch region; other site 573413002860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413002861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002862 dimer interface [polypeptide binding]; other site 573413002863 conserved gate region; other site 573413002864 putative PBP binding loops; other site 573413002865 ABC-ATPase subunit interface; other site 573413002866 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 573413002867 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 573413002868 Outer membrane efflux protein; Region: OEP; pfam02321 573413002869 Outer membrane efflux protein; Region: OEP; pfam02321 573413002870 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413002871 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413002872 Protein export membrane protein; Region: SecD_SecF; cl14618 573413002873 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 573413002874 Protein of unknown function, DUF608; Region: DUF608; pfam04685 573413002875 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 573413002876 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 573413002877 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 573413002878 putative ADP-binding pocket [chemical binding]; other site 573413002879 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573413002880 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 573413002881 active site 573413002882 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 573413002883 agmatinase; Region: agmatinase; TIGR01230 573413002884 putative active site [active] 573413002885 Mn binding site [ion binding]; other site 573413002886 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 573413002887 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 573413002888 dimer interface [polypeptide binding]; other site 573413002889 active site 573413002890 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413002891 catalytic residues [active] 573413002892 substrate binding site [chemical binding]; other site 573413002893 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 573413002894 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 573413002895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413002896 S-adenosylmethionine binding site [chemical binding]; other site 573413002897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002899 DNA binding site [nucleotide binding] 573413002900 domain linker motif; other site 573413002901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413002902 ligand binding site [chemical binding]; other site 573413002903 dimerization interface [polypeptide binding]; other site 573413002904 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 573413002905 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 573413002906 active site 573413002907 homodimer interface [polypeptide binding]; other site 573413002908 catalytic site [active] 573413002909 TIGR03545 family protein; Region: TIGR03545 573413002910 TIGR03546 family protein; Region: TIGR03546 573413002911 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413002912 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413002913 substrate binding site [chemical binding]; other site 573413002914 ATP binding site [chemical binding]; other site 573413002915 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 573413002916 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573413002917 active site 573413002918 intersubunit interface [polypeptide binding]; other site 573413002919 catalytic residue [active] 573413002920 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 573413002921 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 573413002922 Bacterial transcriptional regulator; Region: IclR; pfam01614 573413002923 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413002924 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413002925 substrate binding pocket [chemical binding]; other site 573413002926 membrane-bound complex binding site; other site 573413002927 hinge residues; other site 573413002928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573413002929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002930 dimer interface [polypeptide binding]; other site 573413002931 conserved gate region; other site 573413002932 putative PBP binding loops; other site 573413002933 ABC-ATPase subunit interface; other site 573413002934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413002935 ABC-ATPase subunit interface; other site 573413002936 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413002937 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413002938 Walker A/P-loop; other site 573413002939 ATP binding site [chemical binding]; other site 573413002940 Q-loop/lid; other site 573413002941 ABC transporter signature motif; other site 573413002942 Walker B; other site 573413002943 D-loop; other site 573413002944 H-loop/switch region; other site 573413002945 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573413002946 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413002947 catalytic residue [active] 573413002948 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 573413002949 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 573413002950 NADP binding site [chemical binding]; other site 573413002951 homodimer interface [polypeptide binding]; other site 573413002952 active site 573413002953 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413002954 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413002955 NAD(P) binding site [chemical binding]; other site 573413002956 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 573413002957 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 573413002958 ligand binding site [chemical binding]; other site 573413002959 NAD binding site [chemical binding]; other site 573413002960 catalytic site [active] 573413002961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413002962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413002963 DNA binding site [nucleotide binding] 573413002964 domain linker motif; other site 573413002965 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413002966 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 573413002967 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573413002968 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 573413002969 trimer interface [polypeptide binding]; other site 573413002970 active site 573413002971 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 573413002972 catalytic site [active] 573413002973 SGNH_hydrolase subfamily, similar to arylesterase (7-aminocephalosporanic acid-deacetylating enzyme) of A. tumefaciens. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of...; Region: SGNH_arylesterase_like; cd01839 573413002974 active site 573413002975 catalytic triad [active] 573413002976 oxyanion hole [active] 573413002977 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 573413002978 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573413002979 Clp amino terminal domain; Region: Clp_N; pfam02861 573413002980 Clp amino terminal domain; Region: Clp_N; pfam02861 573413002981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413002982 Walker A motif; other site 573413002983 ATP binding site [chemical binding]; other site 573413002984 Walker B motif; other site 573413002985 arginine finger; other site 573413002986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413002987 Walker A motif; other site 573413002988 ATP binding site [chemical binding]; other site 573413002989 Walker B motif; other site 573413002990 arginine finger; other site 573413002991 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573413002992 Protein of unknown function (DUF3187); Region: DUF3187; pfam11383 573413002993 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 573413002994 Ligand binding site; other site 573413002995 metal-binding site 573413002996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413002997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413002998 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413002999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003000 dimer interface [polypeptide binding]; other site 573413003001 conserved gate region; other site 573413003002 putative PBP binding loops; other site 573413003003 ABC-ATPase subunit interface; other site 573413003004 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003006 dimer interface [polypeptide binding]; other site 573413003007 conserved gate region; other site 573413003008 putative PBP binding loops; other site 573413003009 ABC-ATPase subunit interface; other site 573413003010 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573413003011 metal ion-dependent adhesion site (MIDAS); other site 573413003012 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 573413003013 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 573413003014 Protein of unknown function (DUF554); Region: DUF554; pfam04474 573413003015 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573413003016 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573413003017 homodimer interface [polypeptide binding]; other site 573413003018 active site pocket [active] 573413003019 Nif-specific regulatory protein; Region: nifA; TIGR01817 573413003020 GAF domain; Region: GAF; pfam01590 573413003021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413003022 Walker A motif; other site 573413003023 ATP binding site [chemical binding]; other site 573413003024 Walker B motif; other site 573413003025 arginine finger; other site 573413003026 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413003027 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 573413003028 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 573413003029 transcription termination/antitermination factor NusG; Region: nusG; TIGR00922 573413003030 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573413003031 putative homodimer interface [polypeptide binding]; other site 573413003032 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573413003033 heterodimer interface [polypeptide binding]; other site 573413003034 homodimer interface [polypeptide binding]; other site 573413003035 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573413003036 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573413003037 23S rRNA interface [nucleotide binding]; other site 573413003038 L7/L12 interface [polypeptide binding]; other site 573413003039 putative thiostrepton binding site; other site 573413003040 L25 interface [polypeptide binding]; other site 573413003041 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573413003042 mRNA/rRNA interface [nucleotide binding]; other site 573413003043 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573413003044 23S rRNA interface [nucleotide binding]; other site 573413003045 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573413003046 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573413003047 peripheral dimer interface [polypeptide binding]; other site 573413003048 core dimer interface [polypeptide binding]; other site 573413003049 L10 interface [polypeptide binding]; other site 573413003050 L11 interface [polypeptide binding]; other site 573413003051 putative EF-Tu interaction site [polypeptide binding]; other site 573413003052 putative EF-G interaction site [polypeptide binding]; other site 573413003053 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573413003054 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573413003055 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573413003056 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573413003057 RPB10 interaction site [polypeptide binding]; other site 573413003058 RPB1 interaction site [polypeptide binding]; other site 573413003059 RPB11 interaction site [polypeptide binding]; other site 573413003060 RPB3 interaction site [polypeptide binding]; other site 573413003061 RPB12 interaction site [polypeptide binding]; other site 573413003062 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573413003063 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 573413003064 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573413003065 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573413003066 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573413003067 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573413003068 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 573413003069 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573413003070 DNA binding site [nucleotide binding] 573413003071 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573413003072 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573413003073 S17 interaction site [polypeptide binding]; other site 573413003074 S8 interaction site; other site 573413003075 16S rRNA interaction site [nucleotide binding]; other site 573413003076 streptomycin interaction site [chemical binding]; other site 573413003077 23S rRNA interaction site [nucleotide binding]; other site 573413003078 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573413003079 30S ribosomal protein S7; Validated; Region: PRK05302 573413003080 elongation factor Tu; Reviewed; Region: PRK00049 573413003081 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573413003082 G1 box; other site 573413003083 GEF interaction site [polypeptide binding]; other site 573413003084 GTP/Mg2+ binding site [chemical binding]; other site 573413003085 Switch I region; other site 573413003086 G2 box; other site 573413003087 G3 box; other site 573413003088 Switch II region; other site 573413003089 G4 box; other site 573413003090 G5 box; other site 573413003091 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573413003092 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573413003093 Antibiotic Binding Site [chemical binding]; other site 573413003094 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573413003095 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573413003096 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573413003097 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573413003098 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573413003099 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573413003100 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573413003101 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573413003102 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573413003103 putative translocon binding site; other site 573413003104 protein-rRNA interface [nucleotide binding]; other site 573413003105 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573413003106 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573413003107 G-X-X-G motif; other site 573413003108 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573413003109 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573413003110 23S rRNA interface [nucleotide binding]; other site 573413003111 5S rRNA interface [nucleotide binding]; other site 573413003112 putative antibiotic binding site [chemical binding]; other site 573413003113 L25 interface [polypeptide binding]; other site 573413003114 L27 interface [polypeptide binding]; other site 573413003115 50S ribosomal protein L29; Reviewed; Region: PRK00306 573413003116 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573413003117 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573413003118 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573413003119 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573413003120 RNA binding site [nucleotide binding]; other site 573413003121 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573413003122 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573413003123 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573413003124 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 573413003125 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573413003126 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573413003127 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573413003128 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573413003129 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573413003130 23S rRNA interface [nucleotide binding]; other site 573413003131 L21e interface [polypeptide binding]; other site 573413003132 5S rRNA interface [nucleotide binding]; other site 573413003133 L27 interface [polypeptide binding]; other site 573413003134 L5 interface [polypeptide binding]; other site 573413003135 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573413003136 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573413003137 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573413003138 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573413003139 23S rRNA binding site [nucleotide binding]; other site 573413003140 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573413003141 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573413003142 SecY translocase; Region: SecY; pfam00344 573413003143 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 573413003144 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 573413003145 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573413003146 30S ribosomal protein S11; Validated; Region: PRK05309 573413003147 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573413003148 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573413003149 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573413003150 RNA binding surface [nucleotide binding]; other site 573413003151 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573413003152 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573413003153 alphaNTD homodimer interface [polypeptide binding]; other site 573413003154 alphaNTD - beta interaction site [polypeptide binding]; other site 573413003155 alphaNTD - beta' interaction site [polypeptide binding]; other site 573413003156 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573413003157 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573413003158 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 573413003159 Carbon starvation protein CstA; Region: CstA; pfam02554 573413003160 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573413003161 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 573413003162 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 573413003163 P loop; other site 573413003164 Nucleotide binding site [chemical binding]; other site 573413003165 DTAP/Switch II; other site 573413003166 Switch I; other site 573413003167 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413003168 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413003169 ligand binding site [chemical binding]; other site 573413003170 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413003171 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413003172 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413003173 dimer interface [polypeptide binding]; other site 573413003174 putative CheW interface [polypeptide binding]; other site 573413003175 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 573413003176 Malic enzyme, N-terminal domain; Region: malic; pfam00390 573413003177 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 573413003178 putative NAD(P) binding site [chemical binding]; other site 573413003179 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 573413003180 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 573413003181 Phosphoglycerate kinase; Region: PGK; pfam00162 573413003182 substrate binding site [chemical binding]; other site 573413003183 hinge regions; other site 573413003184 ADP binding site [chemical binding]; other site 573413003185 catalytic site [active] 573413003186 glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207 573413003187 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573413003188 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573413003189 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 573413003190 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573413003191 tetramer interface [polypeptide binding]; other site 573413003192 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 573413003193 active site 573413003194 Mg2+/Mn2+ binding site [ion binding]; other site 573413003195 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573413003196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413003197 DNA-binding site [nucleotide binding]; DNA binding site 573413003198 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573413003199 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573413003200 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 573413003201 putative ligand binding site [chemical binding]; other site 573413003202 putative NAD binding site [chemical binding]; other site 573413003203 catalytic site [active] 573413003204 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413003205 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 573413003206 putative N- and C-terminal domain interface [polypeptide binding]; other site 573413003207 putative active site [active] 573413003208 MgATP binding site [chemical binding]; other site 573413003209 catalytic site [active] 573413003210 metal binding site [ion binding]; metal-binding site 573413003211 putative xylulose binding site [chemical binding]; other site 573413003212 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573413003213 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 573413003214 intersubunit interface [polypeptide binding]; other site 573413003215 active site 573413003216 Zn2+ binding site [ion binding]; other site 573413003217 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 573413003218 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413003219 AP (apurinic/apyrimidinic) site pocket; other site 573413003220 DNA interaction; other site 573413003221 Metal-binding active site; metal-binding site 573413003222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413003223 Methyltransferase domain; Region: Methyltransf_25; pfam13649 573413003224 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 573413003225 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413003226 metal binding site [ion binding]; metal-binding site 573413003227 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 573413003228 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573413003229 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573413003230 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 573413003231 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573413003232 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 573413003233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003234 dimer interface [polypeptide binding]; other site 573413003235 conserved gate region; other site 573413003236 ABC-ATPase subunit interface; other site 573413003237 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 573413003238 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 573413003239 Walker A/P-loop; other site 573413003240 ATP binding site [chemical binding]; other site 573413003241 Q-loop/lid; other site 573413003242 ABC transporter signature motif; other site 573413003243 Walker B; other site 573413003244 D-loop; other site 573413003245 H-loop/switch region; other site 573413003246 FOG: CBS domain [General function prediction only]; Region: COG0517 573413003247 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573413003248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003249 dimer interface [polypeptide binding]; other site 573413003250 conserved gate region; other site 573413003251 putative PBP binding loops; other site 573413003252 ABC-ATPase subunit interface; other site 573413003253 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413003254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413003255 putative Zn2+ binding site [ion binding]; other site 573413003256 putative DNA binding site [nucleotide binding]; other site 573413003257 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 573413003258 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 573413003259 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 573413003260 Predicted permeases [General function prediction only]; Region: COG0701 573413003261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573413003262 catalytic core [active] 573413003263 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 573413003264 cyclase homology domain; Region: CHD; cd07302 573413003265 nucleotidyl binding site; other site 573413003266 metal binding site [ion binding]; metal-binding site 573413003267 dimer interface [polypeptide binding]; other site 573413003268 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573413003269 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573413003270 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 573413003271 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573413003272 N-terminal plug; other site 573413003273 ligand-binding site [chemical binding]; other site 573413003274 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573413003275 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413003276 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413003277 homodimer interface [polypeptide binding]; other site 573413003278 catalytic residue [active] 573413003279 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413003280 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 573413003281 putative ligand binding site [chemical binding]; other site 573413003282 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 573413003283 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413003284 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413003285 dimer interface [polypeptide binding]; other site 573413003286 putative PBP binding regions; other site 573413003287 ABC-ATPase subunit interface; other site 573413003288 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413003289 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413003290 Walker A/P-loop; other site 573413003291 ATP binding site [chemical binding]; other site 573413003292 Q-loop/lid; other site 573413003293 ABC transporter signature motif; other site 573413003294 Walker B; other site 573413003295 D-loop; other site 573413003296 H-loop/switch region; other site 573413003297 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573413003298 homotrimer interaction site [polypeptide binding]; other site 573413003299 putative active site [active] 573413003300 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413003301 dipeptidase, putative; Region: dipeptidaselike; TIGR01887 573413003302 metal binding site [ion binding]; metal-binding site 573413003303 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 573413003304 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 573413003305 putative substrate binding site [chemical binding]; other site 573413003306 nucleotide binding site [chemical binding]; other site 573413003307 nucleotide binding site [chemical binding]; other site 573413003308 homodimer interface [polypeptide binding]; other site 573413003309 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 573413003310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413003311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413003312 homodimer interface [polypeptide binding]; other site 573413003313 catalytic residue [active] 573413003314 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 573413003315 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413003316 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413003317 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413003318 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 573413003319 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413003320 nucleotide binding site [chemical binding]; other site 573413003321 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 573413003322 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573413003323 PYR/PP interface [polypeptide binding]; other site 573413003324 dimer interface [polypeptide binding]; other site 573413003325 TPP binding site [chemical binding]; other site 573413003326 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413003327 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573413003328 TPP-binding site [chemical binding]; other site 573413003329 dimer interface [polypeptide binding]; other site 573413003330 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413003331 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 573413003332 ligand binding site [chemical binding]; other site 573413003333 dimerization interface [polypeptide binding]; other site 573413003334 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 573413003335 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413003336 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413003337 Walker A/P-loop; other site 573413003338 ATP binding site [chemical binding]; other site 573413003339 Q-loop/lid; other site 573413003340 ABC transporter signature motif; other site 573413003341 Walker B; other site 573413003342 D-loop; other site 573413003343 H-loop/switch region; other site 573413003344 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413003345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003346 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413003347 TM-ABC transporter signature motif; other site 573413003348 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 573413003349 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 573413003350 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573413003351 substrate binding site [chemical binding]; other site 573413003352 trimer interface [polypeptide binding]; other site 573413003353 Mn binding site [ion binding]; other site 573413003354 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 573413003355 asparagine synthetase AsnA; Provisional; Region: PRK05425 573413003356 motif 1; other site 573413003357 dimer interface [polypeptide binding]; other site 573413003358 active site 573413003359 motif 2; other site 573413003360 motif 3; other site 573413003361 Hemerythrin; Region: Hemerythrin; cd12107 573413003362 Fe binding site [ion binding]; other site 573413003363 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 573413003364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573413003365 Uncharacterized conserved protein [Function unknown]; Region: COG3339 573413003366 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 573413003367 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 573413003368 Dimer interface [polypeptide binding]; other site 573413003369 anticodon binding site; other site 573413003370 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573413003371 motif 1; other site 573413003372 dimer interface [polypeptide binding]; other site 573413003373 active site 573413003374 motif 2; other site 573413003375 motif 3; other site 573413003376 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573413003377 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573413003378 GatB domain; Region: GatB_Yqey; smart00845 573413003379 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573413003380 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 573413003381 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 573413003382 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 573413003383 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413003384 active site 573413003385 metal binding site [ion binding]; metal-binding site 573413003386 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 573413003387 hybrid cluster protein; Provisional; Region: PRK05290 573413003388 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413003389 ACS interaction site; other site 573413003390 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 573413003391 hybrid metal cluster; other site 573413003392 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413003393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413003394 ligand binding site [chemical binding]; other site 573413003395 flexible hinge region; other site 573413003396 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573413003397 putative switch regulator; other site 573413003398 non-specific DNA interactions [nucleotide binding]; other site 573413003399 DNA binding site [nucleotide binding] 573413003400 sequence specific DNA binding site [nucleotide binding]; other site 573413003401 putative cAMP binding site [chemical binding]; other site 573413003402 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573413003403 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573413003404 dimer interface [polypeptide binding]; other site 573413003405 active site 573413003406 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413003407 substrate binding site [chemical binding]; other site 573413003408 catalytic residues [active] 573413003409 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 573413003410 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573413003411 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573413003412 inner membrane protein; Provisional; Region: PRK11715 573413003413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413003414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413003415 active site 573413003416 phosphorylation site [posttranslational modification] 573413003417 intermolecular recognition site; other site 573413003418 dimerization interface [polypeptide binding]; other site 573413003419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413003420 DNA binding site [nucleotide binding] 573413003421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413003422 HAMP domain; Region: HAMP; pfam00672 573413003423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413003424 dimer interface [polypeptide binding]; other site 573413003425 phosphorylation site [posttranslational modification] 573413003426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003427 ATP binding site [chemical binding]; other site 573413003428 Mg2+ binding site [ion binding]; other site 573413003429 G-X-G motif; other site 573413003430 cytosine deaminase; Validated; Region: PRK07572 573413003431 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 573413003432 active site 573413003433 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413003434 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 573413003435 ligand binding site [chemical binding]; other site 573413003436 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003437 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413003438 TM-ABC transporter signature motif; other site 573413003439 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003440 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413003441 TM-ABC transporter signature motif; other site 573413003442 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413003443 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413003444 Walker A/P-loop; other site 573413003445 ATP binding site [chemical binding]; other site 573413003446 Q-loop/lid; other site 573413003447 ABC transporter signature motif; other site 573413003448 Walker B; other site 573413003449 D-loop; other site 573413003450 H-loop/switch region; other site 573413003451 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413003452 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413003453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413003454 DNA-binding site [nucleotide binding]; DNA binding site 573413003455 UTRA domain; Region: UTRA; cl17743 573413003456 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 573413003457 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413003458 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413003459 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413003460 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413003461 catalytic loop [active] 573413003462 iron binding site [ion binding]; other site 573413003463 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413003464 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 573413003465 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413003466 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413003467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413003468 Histidine kinase; Region: HisKA_3; pfam07730 573413003469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003470 ATP binding site [chemical binding]; other site 573413003471 Mg2+ binding site [ion binding]; other site 573413003472 G-X-G motif; other site 573413003473 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413003474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413003475 active site 573413003476 phosphorylation site [posttranslational modification] 573413003477 intermolecular recognition site; other site 573413003478 dimerization interface [polypeptide binding]; other site 573413003479 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413003480 DNA binding residues [nucleotide binding] 573413003481 dimerization interface [polypeptide binding]; other site 573413003482 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413003483 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413003484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003485 dimer interface [polypeptide binding]; other site 573413003486 conserved gate region; other site 573413003487 putative PBP binding loops; other site 573413003488 ABC-ATPase subunit interface; other site 573413003489 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003491 dimer interface [polypeptide binding]; other site 573413003492 conserved gate region; other site 573413003493 putative PBP binding loops; other site 573413003494 ABC-ATPase subunit interface; other site 573413003495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413003496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413003497 active site 573413003498 catalytic tetrad [active] 573413003499 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 573413003500 Na2 binding site [ion binding]; other site 573413003501 putative substrate binding site 1 [chemical binding]; other site 573413003502 Na binding site 1 [ion binding]; other site 573413003503 putative substrate binding site 2 [chemical binding]; other site 573413003504 Predicted transcriptional regulator [Transcription]; Region: COG2378 573413003505 HTH domain; Region: HTH_11; pfam08279 573413003506 WYL domain; Region: WYL; pfam13280 573413003507 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 573413003508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573413003509 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 573413003510 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 573413003511 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 573413003512 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 573413003513 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 573413003514 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 573413003515 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 573413003516 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 573413003517 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 573413003518 Chromate transporter; Region: Chromate_transp; pfam02417 573413003519 Chromate transporter; Region: Chromate_transp; pfam02417 573413003520 Family description; Region: VCBS; pfam13517 573413003521 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 573413003522 putative active site [active] 573413003523 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573413003524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413003525 non-specific DNA binding site [nucleotide binding]; other site 573413003526 salt bridge; other site 573413003527 sequence-specific DNA binding site [nucleotide binding]; other site 573413003528 Domain of unknown function (DUF955); Region: DUF955; cl01076 573413003529 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 573413003530 YARHG domain; Region: YARHG; pfam13308 573413003531 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 573413003532 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 573413003533 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573413003534 catalytic core [active] 573413003535 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413003536 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573413003537 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413003538 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 573413003539 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573413003540 dimer interface [polypeptide binding]; other site 573413003541 active site 573413003542 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413003543 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 573413003544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003545 dimer interface [polypeptide binding]; other site 573413003546 conserved gate region; other site 573413003547 putative PBP binding loops; other site 573413003548 ABC-ATPase subunit interface; other site 573413003549 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003551 dimer interface [polypeptide binding]; other site 573413003552 conserved gate region; other site 573413003553 putative PBP binding loops; other site 573413003554 ABC-ATPase subunit interface; other site 573413003555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413003556 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413003557 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413003558 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413003559 substrate binding site [chemical binding]; other site 573413003560 ATP binding site [chemical binding]; other site 573413003561 Sensory domain found in PocR; Region: PocR; pfam10114 573413003562 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 573413003563 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413003564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413003565 putative active site [active] 573413003566 heme pocket [chemical binding]; other site 573413003567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413003568 dimer interface [polypeptide binding]; other site 573413003569 phosphorylation site [posttranslational modification] 573413003570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003571 ATP binding site [chemical binding]; other site 573413003572 Mg2+ binding site [ion binding]; other site 573413003573 G-X-G motif; other site 573413003574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413003575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413003576 active site 573413003577 phosphorylation site [posttranslational modification] 573413003578 intermolecular recognition site; other site 573413003579 dimerization interface [polypeptide binding]; other site 573413003580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413003581 DNA binding residues [nucleotide binding] 573413003582 dimerization interface [polypeptide binding]; other site 573413003583 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413003584 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413003585 catalytic loop [active] 573413003586 iron binding site [ion binding]; other site 573413003587 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413003588 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573413003589 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413003590 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413003591 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 573413003592 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 573413003593 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 573413003594 Ligand binding site [chemical binding]; other site 573413003595 Electron transfer flavoprotein domain; Region: ETF; pfam01012 573413003596 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 573413003597 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 573413003598 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 573413003599 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 573413003600 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 573413003601 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 573413003602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413003603 DNA binding site [nucleotide binding] 573413003604 domain linker motif; other site 573413003605 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413003606 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413003607 ligand binding site [chemical binding]; other site 573413003608 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413003609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413003610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413003611 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 573413003612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413003613 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413003614 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413003615 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413003616 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413003617 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413003618 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413003619 Walker A/P-loop; other site 573413003620 ATP binding site [chemical binding]; other site 573413003621 Q-loop/lid; other site 573413003622 ABC transporter signature motif; other site 573413003623 Walker B; other site 573413003624 D-loop; other site 573413003625 H-loop/switch region; other site 573413003626 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413003627 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003628 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413003629 TM-ABC transporter signature motif; other site 573413003630 AAA domain; Region: AAA_14; pfam13173 573413003631 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 573413003632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573413003633 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573413003634 AMP binding site [chemical binding]; other site 573413003635 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 573413003636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413003637 active site 573413003638 nucleotide binding site [chemical binding]; other site 573413003639 HIGH motif; other site 573413003640 KMSKS motif; other site 573413003641 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 573413003642 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 573413003643 Flavodoxin domain; Region: Flavodoxin_3; pfam12641 573413003644 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413003645 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413003646 ABC-ATPase subunit interface; other site 573413003647 dimer interface [polypeptide binding]; other site 573413003648 putative PBP binding regions; other site 573413003649 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413003650 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413003651 Walker A/P-loop; other site 573413003652 ATP binding site [chemical binding]; other site 573413003653 Q-loop/lid; other site 573413003654 ABC transporter signature motif; other site 573413003655 Walker B; other site 573413003656 D-loop; other site 573413003657 H-loop/switch region; other site 573413003658 putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107 573413003659 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413003660 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 573413003661 intersubunit interface [polypeptide binding]; other site 573413003662 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 573413003663 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 573413003664 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573413003665 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573413003666 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573413003667 enterobactin receptor protein; Provisional; Region: PRK13483 573413003668 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573413003669 N-terminal plug; other site 573413003670 ligand-binding site [chemical binding]; other site 573413003671 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 573413003672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413003673 NAD(P) binding site [chemical binding]; other site 573413003674 active site 573413003675 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 573413003676 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 573413003677 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 573413003678 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 573413003679 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 573413003680 hypothetical protein; Provisional; Region: PRK09947 573413003681 putative oxidoreductase; Provisional; Region: PRK09849 573413003682 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 573413003683 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573413003684 hypothetical protein; Provisional; Region: PRK09898 573413003685 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413003686 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 573413003687 Domain of unknown function (DUF364); Region: DUF364; pfam04016 573413003688 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573413003689 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 573413003690 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573413003691 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 573413003692 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573413003693 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 573413003694 active site 573413003695 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573413003696 Beta-lactamase; Region: Beta-lactamase; cl17358 573413003697 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 573413003698 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 573413003699 putative active site [active] 573413003700 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 573413003701 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413003702 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 573413003703 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413003704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003705 dimer interface [polypeptide binding]; other site 573413003706 conserved gate region; other site 573413003707 putative PBP binding loops; other site 573413003708 ABC-ATPase subunit interface; other site 573413003709 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573413003710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573413003711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003712 dimer interface [polypeptide binding]; other site 573413003713 conserved gate region; other site 573413003714 putative PBP binding loops; other site 573413003715 ABC-ATPase subunit interface; other site 573413003716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413003717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413003718 Walker A/P-loop; other site 573413003719 ATP binding site [chemical binding]; other site 573413003720 Q-loop/lid; other site 573413003721 ABC transporter signature motif; other site 573413003722 Walker B; other site 573413003723 D-loop; other site 573413003724 H-loop/switch region; other site 573413003725 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413003726 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 573413003727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413003728 Walker A/P-loop; other site 573413003729 ATP binding site [chemical binding]; other site 573413003730 Q-loop/lid; other site 573413003731 ABC transporter signature motif; other site 573413003732 Walker B; other site 573413003733 D-loop; other site 573413003734 H-loop/switch region; other site 573413003735 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413003736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413003737 Coenzyme A binding pocket [chemical binding]; other site 573413003738 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573413003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413003740 Coenzyme A binding pocket [chemical binding]; other site 573413003741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573413003742 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573413003743 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 573413003744 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413003745 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413003746 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413003747 putative active site [active] 573413003748 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413003749 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 573413003750 substrate binding site [chemical binding]; other site 573413003751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413003752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003753 dimer interface [polypeptide binding]; other site 573413003754 conserved gate region; other site 573413003755 putative PBP binding loops; other site 573413003756 ABC-ATPase subunit interface; other site 573413003757 dipeptide transporter; Provisional; Region: PRK10913 573413003758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003759 dimer interface [polypeptide binding]; other site 573413003760 conserved gate region; other site 573413003761 putative PBP binding loops; other site 573413003762 ABC-ATPase subunit interface; other site 573413003763 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413003764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413003765 Walker A/P-loop; other site 573413003766 ATP binding site [chemical binding]; other site 573413003767 Q-loop/lid; other site 573413003768 ABC transporter signature motif; other site 573413003769 Walker B; other site 573413003770 D-loop; other site 573413003771 H-loop/switch region; other site 573413003772 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413003773 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413003774 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413003775 Walker A/P-loop; other site 573413003776 ATP binding site [chemical binding]; other site 573413003777 Q-loop/lid; other site 573413003778 ABC transporter signature motif; other site 573413003779 Walker B; other site 573413003780 D-loop; other site 573413003781 H-loop/switch region; other site 573413003782 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413003783 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413003784 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413003785 DNA binding site [nucleotide binding] 573413003786 domain linker motif; other site 573413003787 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413003788 dimerization interface [polypeptide binding]; other site 573413003789 ligand binding site [chemical binding]; other site 573413003790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003791 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413003792 TM-ABC transporter signature motif; other site 573413003793 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413003794 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413003795 Walker A/P-loop; other site 573413003796 ATP binding site [chemical binding]; other site 573413003797 Q-loop/lid; other site 573413003798 ABC transporter signature motif; other site 573413003799 Walker B; other site 573413003800 D-loop; other site 573413003801 H-loop/switch region; other site 573413003802 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413003803 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413003804 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413003805 ligand binding site [chemical binding]; other site 573413003806 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413003807 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573413003808 substrate binding site [chemical binding]; other site 573413003809 dimer interface [polypeptide binding]; other site 573413003810 ATP binding site [chemical binding]; other site 573413003811 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 573413003812 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573413003813 intersubunit interface [polypeptide binding]; other site 573413003814 active site 573413003815 catalytic residue [active] 573413003816 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413003817 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413003818 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573413003819 substrate binding site [chemical binding]; other site 573413003820 dimer interface [polypeptide binding]; other site 573413003821 ATP binding site [chemical binding]; other site 573413003822 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 573413003823 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 573413003824 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413003825 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 573413003826 ligand binding site [chemical binding]; other site 573413003827 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413003828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413003829 catalytic loop [active] 573413003830 iron binding site [ion binding]; other site 573413003831 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413003832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003833 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413003834 TM-ABC transporter signature motif; other site 573413003835 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413003836 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413003837 TM-ABC transporter signature motif; other site 573413003838 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413003839 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413003840 Walker A/P-loop; other site 573413003841 ATP binding site [chemical binding]; other site 573413003842 Q-loop/lid; other site 573413003843 ABC transporter signature motif; other site 573413003844 Walker B; other site 573413003845 D-loop; other site 573413003846 H-loop/switch region; other site 573413003847 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413003848 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413003849 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413003850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413003851 Histidine kinase; Region: HisKA_2; pfam07568 573413003852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003853 ATP binding site [chemical binding]; other site 573413003854 Mg2+ binding site [ion binding]; other site 573413003855 G-X-G motif; other site 573413003856 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 573413003857 Two component regulator propeller; Region: Reg_prop; pfam07494 573413003858 Two component regulator propeller; Region: Reg_prop; pfam07494 573413003859 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 573413003860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413003861 dimer interface [polypeptide binding]; other site 573413003862 phosphorylation site [posttranslational modification] 573413003863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003864 ATP binding site [chemical binding]; other site 573413003865 Mg2+ binding site [ion binding]; other site 573413003866 G-X-G motif; other site 573413003867 Response regulator receiver domain; Region: Response_reg; pfam00072 573413003868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413003869 active site 573413003870 phosphorylation site [posttranslational modification] 573413003871 intermolecular recognition site; other site 573413003872 dimerization interface [polypeptide binding]; other site 573413003873 Predicted kinase [General function prediction only]; Region: COG0645 573413003874 AAA domain; Region: AAA_17; pfam13207 573413003875 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 573413003876 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413003877 tetramer interface [polypeptide binding]; other site 573413003878 catalytic Zn binding site [ion binding]; other site 573413003879 NADP binding site [chemical binding]; other site 573413003880 hypothetical protein; Provisional; Region: PRK04164 573413003881 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573413003882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573413003883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413003884 Coenzyme A binding pocket [chemical binding]; other site 573413003885 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 573413003886 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 573413003887 metal binding site [ion binding]; metal-binding site 573413003888 dimer interface [polypeptide binding]; other site 573413003889 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 573413003890 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573413003891 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573413003892 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413003893 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413003894 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413003895 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413003896 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413003897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003898 dimer interface [polypeptide binding]; other site 573413003899 conserved gate region; other site 573413003900 putative PBP binding loops; other site 573413003901 ABC-ATPase subunit interface; other site 573413003902 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003904 dimer interface [polypeptide binding]; other site 573413003905 conserved gate region; other site 573413003906 putative PBP binding loops; other site 573413003907 ABC-ATPase subunit interface; other site 573413003908 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 573413003909 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573413003910 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 573413003911 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 573413003912 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 573413003913 putative active site [active] 573413003914 Predicted integral membrane protein [Function unknown]; Region: COG0392 573413003915 Uncharacterized conserved protein [Function unknown]; Region: COG2898 573413003916 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 573413003917 Cobalt transport protein; Region: CbiQ; cl00463 573413003918 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413003919 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413003920 Walker A/P-loop; other site 573413003921 ATP binding site [chemical binding]; other site 573413003922 Q-loop/lid; other site 573413003923 ABC transporter signature motif; other site 573413003924 Walker B; other site 573413003925 D-loop; other site 573413003926 H-loop/switch region; other site 573413003927 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413003928 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413003929 Walker A/P-loop; other site 573413003930 ATP binding site [chemical binding]; other site 573413003931 Q-loop/lid; other site 573413003932 ABC transporter signature motif; other site 573413003933 Walker B; other site 573413003934 D-loop; other site 573413003935 H-loop/switch region; other site 573413003936 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573413003937 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 573413003938 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573413003939 AsnC family; Region: AsnC_trans_reg; pfam01037 573413003940 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 573413003941 putative deacylase active site [active] 573413003942 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 573413003943 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413003944 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413003945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003946 dimer interface [polypeptide binding]; other site 573413003947 conserved gate region; other site 573413003948 putative PBP binding loops; other site 573413003949 ABC-ATPase subunit interface; other site 573413003950 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003952 dimer interface [polypeptide binding]; other site 573413003953 conserved gate region; other site 573413003954 putative PBP binding loops; other site 573413003955 ABC-ATPase subunit interface; other site 573413003956 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573413003957 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573413003958 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573413003959 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573413003960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413003961 dimerization interface [polypeptide binding]; other site 573413003962 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 573413003963 ligand binding site [chemical binding]; other site 573413003964 Histidine kinase; Region: HisKA_3; pfam07730 573413003965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413003966 ATP binding site [chemical binding]; other site 573413003967 Mg2+ binding site [ion binding]; other site 573413003968 G-X-G motif; other site 573413003969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413003970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413003971 active site 573413003972 phosphorylation site [posttranslational modification] 573413003973 intermolecular recognition site; other site 573413003974 dimerization interface [polypeptide binding]; other site 573413003975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413003976 DNA binding residues [nucleotide binding] 573413003977 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573413003978 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 573413003979 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 573413003980 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413003981 active site 573413003982 putative substrate binding pocket [chemical binding]; other site 573413003983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003984 dimer interface [polypeptide binding]; other site 573413003985 conserved gate region; other site 573413003986 putative PBP binding loops; other site 573413003987 ABC-ATPase subunit interface; other site 573413003988 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413003989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413003990 dimer interface [polypeptide binding]; other site 573413003991 conserved gate region; other site 573413003992 putative PBP binding loops; other site 573413003993 ABC-ATPase subunit interface; other site 573413003994 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413003995 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413003996 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573413003997 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573413003998 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573413003999 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573413004000 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573413004001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413004002 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413004003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413004004 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413004005 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413004006 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413004007 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 573413004008 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413004009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004010 dimer interface [polypeptide binding]; other site 573413004011 conserved gate region; other site 573413004012 putative PBP binding loops; other site 573413004013 ABC-ATPase subunit interface; other site 573413004014 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413004015 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413004016 DNA-binding site [nucleotide binding]; DNA binding site 573413004017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413004018 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413004019 dimerization interface [polypeptide binding]; other site 573413004020 ligand binding site [chemical binding]; other site 573413004021 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573413004022 active site 573413004023 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 573413004024 putative active site [active] 573413004025 catalytic site [active] 573413004026 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 573413004027 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 573413004028 active site 573413004029 catalytic site [active] 573413004030 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 573413004031 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 573413004032 FMN-binding domain; Region: FMN_bind; pfam04205 573413004033 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413004034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413004035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413004036 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 573413004037 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 573413004038 NAD(P) binding site [chemical binding]; other site 573413004039 LDH/MDH dimer interface [polypeptide binding]; other site 573413004040 substrate binding site [chemical binding]; other site 573413004041 alpha-galactosidase; Provisional; Region: PRK15076 573413004042 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 573413004043 NAD binding site [chemical binding]; other site 573413004044 sugar binding site [chemical binding]; other site 573413004045 divalent metal binding site [ion binding]; other site 573413004046 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413004047 dimer interface [polypeptide binding]; other site 573413004048 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 573413004049 active site 573413004050 catalytic residues [active] 573413004051 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413004052 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413004053 TM-ABC transporter signature motif; other site 573413004054 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413004055 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 573413004056 Walker A/P-loop; other site 573413004057 ATP binding site [chemical binding]; other site 573413004058 Q-loop/lid; other site 573413004059 ABC transporter signature motif; other site 573413004060 Walker B; other site 573413004061 D-loop; other site 573413004062 H-loop/switch region; other site 573413004063 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413004064 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 573413004065 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 573413004066 ligand binding site [chemical binding]; other site 573413004067 calcium binding site [ion binding]; other site 573413004068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413004069 putative DNA binding site [nucleotide binding]; other site 573413004070 putative Zn2+ binding site [ion binding]; other site 573413004071 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413004072 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413004073 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 573413004074 AzlC protein; Region: AzlC; pfam03591 573413004075 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 573413004076 AAA ATPase domain; Region: AAA_16; pfam13191 573413004077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413004078 binding surface 573413004079 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413004080 TPR motif; other site 573413004081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413004082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413004083 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413004084 DNA binding residues [nucleotide binding] 573413004085 dimerization interface [polypeptide binding]; other site 573413004086 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 573413004087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413004088 FeS/SAM binding site; other site 573413004089 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 573413004090 Cache domain; Region: Cache_1; pfam02743 573413004091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413004092 Histidine kinase; Region: HisKA_2; pfam07568 573413004093 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413004094 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573413004095 FtsX-like permease family; Region: FtsX; pfam02687 573413004096 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413004097 FtsX-like permease family; Region: FtsX; pfam02687 573413004098 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413004099 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573413004100 Walker A/P-loop; other site 573413004101 ATP binding site [chemical binding]; other site 573413004102 Q-loop/lid; other site 573413004103 ABC transporter signature motif; other site 573413004104 Walker B; other site 573413004105 D-loop; other site 573413004106 H-loop/switch region; other site 573413004107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413004108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413004109 dimer interface [polypeptide binding]; other site 573413004110 phosphorylation site [posttranslational modification] 573413004111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004112 ATP binding site [chemical binding]; other site 573413004113 Mg2+ binding site [ion binding]; other site 573413004114 G-X-G motif; other site 573413004115 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413004116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004117 active site 573413004118 phosphorylation site [posttranslational modification] 573413004119 intermolecular recognition site; other site 573413004120 dimerization interface [polypeptide binding]; other site 573413004121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413004122 DNA binding site [nucleotide binding] 573413004123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413004124 S-adenosylmethionine binding site [chemical binding]; other site 573413004125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 573413004126 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 573413004127 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 573413004128 putative aldolase; Validated; Region: PRK08130 573413004129 intersubunit interface [polypeptide binding]; other site 573413004130 active site 573413004131 Zn2+ binding site [ion binding]; other site 573413004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 573413004133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 573413004134 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413004135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413004136 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 573413004137 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 573413004138 Propionate catabolism activator; Region: PrpR_N; pfam06506 573413004139 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 573413004140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413004141 Walker A motif; other site 573413004142 ATP binding site [chemical binding]; other site 573413004143 Walker B motif; other site 573413004144 arginine finger; other site 573413004145 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413004146 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696 573413004147 nudix motif; other site 573413004148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413004149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413004150 DNA binding residues [nucleotide binding] 573413004151 dimerization interface [polypeptide binding]; other site 573413004152 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573413004153 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413004154 Walker A/P-loop; other site 573413004155 ATP binding site [chemical binding]; other site 573413004156 Q-loop/lid; other site 573413004157 ABC transporter signature motif; other site 573413004158 Walker B; other site 573413004159 D-loop; other site 573413004160 H-loop/switch region; other site 573413004161 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573413004162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413004163 dimer interface [polypeptide binding]; other site 573413004164 phosphorylation site [posttranslational modification] 573413004165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004166 ATP binding site [chemical binding]; other site 573413004167 Mg2+ binding site [ion binding]; other site 573413004168 G-X-G motif; other site 573413004169 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573413004170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004171 active site 573413004172 phosphorylation site [posttranslational modification] 573413004173 intermolecular recognition site; other site 573413004174 dimerization interface [polypeptide binding]; other site 573413004175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413004176 Walker A motif; other site 573413004177 ATP binding site [chemical binding]; other site 573413004178 Walker B motif; other site 573413004179 arginine finger; other site 573413004180 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413004181 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 573413004182 active site 573413004183 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413004184 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413004185 ligand binding site [chemical binding]; other site 573413004186 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413004187 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413004188 Walker A/P-loop; other site 573413004189 ATP binding site [chemical binding]; other site 573413004190 Q-loop/lid; other site 573413004191 ABC transporter signature motif; other site 573413004192 Walker B; other site 573413004193 D-loop; other site 573413004194 H-loop/switch region; other site 573413004195 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413004196 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 573413004197 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413004198 TM-ABC transporter signature motif; other site 573413004199 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413004200 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413004201 ligand binding site [chemical binding]; other site 573413004202 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413004203 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413004204 TM-ABC transporter signature motif; other site 573413004205 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 573413004206 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 573413004207 Protein export membrane protein; Region: SecD_SecF; cl14618 573413004208 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413004209 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413004210 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573413004211 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413004212 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413004213 substrate binding site [chemical binding]; other site 573413004214 ATP binding site [chemical binding]; other site 573413004215 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413004216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413004217 Walker A/P-loop; other site 573413004218 ATP binding site [chemical binding]; other site 573413004219 Q-loop/lid; other site 573413004220 ABC transporter signature motif; other site 573413004221 Walker B; other site 573413004222 D-loop; other site 573413004223 H-loop/switch region; other site 573413004224 TOBE domain; Region: TOBE_2; pfam08402 573413004225 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413004226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004227 dimer interface [polypeptide binding]; other site 573413004228 conserved gate region; other site 573413004229 putative PBP binding loops; other site 573413004230 ABC-ATPase subunit interface; other site 573413004231 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004233 dimer interface [polypeptide binding]; other site 573413004234 conserved gate region; other site 573413004235 putative PBP binding loops; other site 573413004236 ABC-ATPase subunit interface; other site 573413004237 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 573413004238 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 573413004239 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413004240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413004241 DNA-binding site [nucleotide binding]; DNA binding site 573413004242 UTRA domain; Region: UTRA; cl17743 573413004243 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413004244 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413004245 TM-ABC transporter signature motif; other site 573413004246 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413004247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413004248 TM-ABC transporter signature motif; other site 573413004249 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413004250 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413004251 Walker A/P-loop; other site 573413004252 ATP binding site [chemical binding]; other site 573413004253 Q-loop/lid; other site 573413004254 ABC transporter signature motif; other site 573413004255 Walker B; other site 573413004256 D-loop; other site 573413004257 H-loop/switch region; other site 573413004258 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413004259 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413004260 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 573413004261 ligand binding site [chemical binding]; other site 573413004262 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 573413004263 putative active site [active] 573413004264 oligoendopeptidase F; Region: pepF; TIGR00181 573413004265 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 573413004266 active site 573413004267 Zn binding site [ion binding]; other site 573413004268 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573413004269 active site 573413004270 dimerization interface [polypeptide binding]; other site 573413004271 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573413004272 DHH family; Region: DHH; pfam01368 573413004273 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573413004274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413004275 Walker A motif; other site 573413004276 ATP binding site [chemical binding]; other site 573413004277 Walker B motif; other site 573413004278 arginine finger; other site 573413004279 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573413004280 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573413004281 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573413004282 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573413004283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573413004284 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 573413004285 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573413004286 oligomer interface [polypeptide binding]; other site 573413004287 active site residues [active] 573413004288 trigger factor; Provisional; Region: tig; PRK01490 573413004289 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573413004290 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573413004291 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 573413004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413004293 Walker A motif; other site 573413004294 ATP binding site [chemical binding]; other site 573413004295 Walker B motif; other site 573413004296 arginine finger; other site 573413004297 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573413004298 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573413004299 anti sigma factor interaction site; other site 573413004300 regulatory phosphorylation site [posttranslational modification]; other site 573413004301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573413004302 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573413004303 Mg2+ binding site [ion binding]; other site 573413004304 G-X-G motif; other site 573413004305 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413004306 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573413004307 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413004308 dimer interface [polypeptide binding]; other site 573413004309 [2Fe-2S] cluster binding site [ion binding]; other site 573413004310 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413004311 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413004312 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413004313 Putative Fe-S cluster; Region: FeS; cl17515 573413004314 PAS domain; Region: PAS; smart00091 573413004315 PAS fold; Region: PAS_7; pfam12860 573413004316 putative active site [active] 573413004317 heme pocket [chemical binding]; other site 573413004318 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573413004319 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573413004320 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573413004321 putative acyl-acceptor binding pocket; other site 573413004322 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573413004323 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573413004324 Chromate transporter; Region: Chromate_transp; pfam02417 573413004325 Chromate transporter; Region: Chromate_transp; pfam02417 573413004326 hypothetical protein; Provisional; Region: PRK04334 573413004327 NIL domain; Region: NIL; pfam09383 573413004328 4Fe-4S binding domain; Region: Fer4; pfam00037 573413004329 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573413004330 4Fe-4S binding domain; Region: Fer4; cl02805 573413004331 Domain of unknown function DUF39; Region: DUF39; pfam01837 573413004332 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413004333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004334 active site 573413004335 phosphorylation site [posttranslational modification] 573413004336 intermolecular recognition site; other site 573413004337 dimerization interface [polypeptide binding]; other site 573413004338 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 573413004339 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 573413004340 active site 573413004341 PHP-associated; Region: PHP_C; pfam13263 573413004342 DRTGG domain; Region: DRTGG; pfam07085 573413004343 FOG: CBS domain [General function prediction only]; Region: COG0517 573413004344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573413004345 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413004346 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 573413004347 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573413004348 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 573413004349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413004350 non-specific DNA binding site [nucleotide binding]; other site 573413004351 salt bridge; other site 573413004352 sequence-specific DNA binding site [nucleotide binding]; other site 573413004353 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573413004354 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 573413004355 anti sigma factor interaction site; other site 573413004356 regulatory phosphorylation site [posttranslational modification]; other site 573413004357 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573413004358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004359 Mg2+ binding site [ion binding]; other site 573413004360 G-X-G motif; other site 573413004361 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413004362 dimerization interface [polypeptide binding]; other site 573413004363 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413004364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413004365 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573413004366 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573413004367 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 573413004368 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 573413004369 active site 573413004370 metal binding site [ion binding]; metal-binding site 573413004371 DNA binding site [nucleotide binding] 573413004372 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 573413004373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413004374 Walker A/P-loop; other site 573413004375 ATP binding site [chemical binding]; other site 573413004376 Q-loop/lid; other site 573413004377 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 573413004378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413004379 ABC transporter signature motif; other site 573413004380 Walker B; other site 573413004381 D-loop; other site 573413004382 H-loop/switch region; other site 573413004383 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413004384 active site 573413004385 phosphorylation site [posttranslational modification] 573413004386 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573413004387 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 573413004388 FOG: CBS domain [General function prediction only]; Region: COG0517 573413004389 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 573413004390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413004391 S-adenosylmethionine binding site [chemical binding]; other site 573413004392 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573413004393 Y-family of DNA polymerases; Region: PolY; cl12025 573413004394 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573413004395 ssDNA binding site; other site 573413004396 generic binding surface II; other site 573413004397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413004398 ATP binding site [chemical binding]; other site 573413004399 putative Mg++ binding site [ion binding]; other site 573413004400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413004401 nucleotide binding region [chemical binding]; other site 573413004402 ATP-binding site [chemical binding]; other site 573413004403 YGGT family; Region: YGGT; pfam02325 573413004404 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573413004405 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 573413004406 active site 573413004407 PHP Thumb interface [polypeptide binding]; other site 573413004408 metal binding site [ion binding]; metal-binding site 573413004409 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573413004410 generic binding surface II; other site 573413004411 generic binding surface I; other site 573413004412 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 573413004413 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413004414 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 573413004415 catalytic loop [active] 573413004416 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573413004417 iron binding site [ion binding]; other site 573413004418 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413004419 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573413004420 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413004421 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413004422 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573413004423 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 573413004424 inhibitor-cofactor binding pocket; inhibition site 573413004425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004426 catalytic residue [active] 573413004427 CoA binding domain; Region: CoA_binding; cl17356 573413004428 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 573413004429 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 573413004430 NAD(P) binding site [chemical binding]; other site 573413004431 homodimer interface [polypeptide binding]; other site 573413004432 substrate binding site [chemical binding]; other site 573413004433 active site 573413004434 Transcription antiterminator [Transcription]; Region: NusG; COG0250 573413004435 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 573413004436 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573413004437 heterodimer interface [polypeptide binding]; other site 573413004438 homodimer interface [polypeptide binding]; other site 573413004439 Sporulation related domain; Region: SPOR; pfam05036 573413004440 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 573413004441 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573413004442 nucleotide binding pocket [chemical binding]; other site 573413004443 K-X-D-G motif; other site 573413004444 catalytic site [active] 573413004445 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573413004446 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 573413004447 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573413004448 Dimer interface [polypeptide binding]; other site 573413004449 BRCT sequence motif; other site 573413004450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573413004451 PEGA domain; Region: PEGA; pfam08308 573413004452 PEGA domain; Region: PEGA; pfam08308 573413004453 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 573413004454 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 573413004455 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573413004456 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573413004457 generic binding surface II; other site 573413004458 generic binding surface I; other site 573413004459 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413004460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413004461 binding surface 573413004462 TPR motif; other site 573413004463 TPR repeat; Region: TPR_11; pfam13414 573413004464 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 573413004465 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 573413004466 Ca binding site [ion binding]; other site 573413004467 active site 573413004468 catalytic site [active] 573413004469 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413004470 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413004471 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413004472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413004473 DNA-binding site [nucleotide binding]; DNA binding site 573413004474 FCD domain; Region: FCD; pfam07729 573413004475 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413004476 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413004477 inhibitor site; inhibition site 573413004478 active site 573413004479 dimer interface [polypeptide binding]; other site 573413004480 catalytic residue [active] 573413004481 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413004482 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573413004483 substrate binding site [chemical binding]; other site 573413004484 dimer interface [polypeptide binding]; other site 573413004485 ATP binding site [chemical binding]; other site 573413004486 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 573413004487 putative active site [active] 573413004488 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413004489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413004490 substrate binding pocket [chemical binding]; other site 573413004491 membrane-bound complex binding site; other site 573413004492 hinge residues; other site 573413004493 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413004494 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413004495 Walker A/P-loop; other site 573413004496 ATP binding site [chemical binding]; other site 573413004497 Q-loop/lid; other site 573413004498 ABC transporter signature motif; other site 573413004499 Walker B; other site 573413004500 D-loop; other site 573413004501 H-loop/switch region; other site 573413004502 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573413004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004504 dimer interface [polypeptide binding]; other site 573413004505 conserved gate region; other site 573413004506 putative PBP binding loops; other site 573413004507 ABC-ATPase subunit interface; other site 573413004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004509 dimer interface [polypeptide binding]; other site 573413004510 conserved gate region; other site 573413004511 putative PBP binding loops; other site 573413004512 ABC-ATPase subunit interface; other site 573413004513 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 573413004514 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573413004515 active site 573413004516 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413004517 dimer interface [polypeptide binding]; other site 573413004518 substrate binding site [chemical binding]; other site 573413004519 catalytic residues [active] 573413004520 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 573413004521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413004522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004523 homodimer interface [polypeptide binding]; other site 573413004524 catalytic residue [active] 573413004525 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 573413004526 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 573413004527 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 573413004528 Cache domain; Region: Cache_2; cl07034 573413004529 Cache domain; Region: Cache_1; pfam02743 573413004530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413004531 dimerization interface [polypeptide binding]; other site 573413004532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413004533 Histidine kinase; Region: HisKA_2; pfam07568 573413004534 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 573413004535 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 573413004536 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 573413004537 active site 573413004538 dimer interface [polypeptide binding]; other site 573413004539 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413004540 dimerization interface [polypeptide binding]; other site 573413004541 Histidine kinase; Region: His_kinase; pfam06580 573413004542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004543 ATP binding site [chemical binding]; other site 573413004544 Mg2+ binding site [ion binding]; other site 573413004545 G-X-G motif; other site 573413004546 Response regulator receiver domain; Region: Response_reg; pfam00072 573413004547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004548 active site 573413004549 phosphorylation site [posttranslational modification] 573413004550 intermolecular recognition site; other site 573413004551 dimerization interface [polypeptide binding]; other site 573413004552 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573413004553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413004554 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 573413004555 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573413004556 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413004557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004558 dimer interface [polypeptide binding]; other site 573413004559 conserved gate region; other site 573413004560 putative PBP binding loops; other site 573413004561 ABC-ATPase subunit interface; other site 573413004562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413004563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573413004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004565 dimer interface [polypeptide binding]; other site 573413004566 ABC-ATPase subunit interface; other site 573413004567 putative PBP binding loops; other site 573413004568 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413004569 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413004570 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573413004571 active site 573413004572 catalytic site [active] 573413004573 substrate binding site [chemical binding]; other site 573413004574 HRDC domain; Region: HRDC; cl02578 573413004575 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413004576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413004577 S-adenosylmethionine binding site [chemical binding]; other site 573413004578 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413004579 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413004580 intersubunit interface [polypeptide binding]; other site 573413004581 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413004582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413004583 ABC-ATPase subunit interface; other site 573413004584 dimer interface [polypeptide binding]; other site 573413004585 putative PBP binding regions; other site 573413004586 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413004587 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413004588 Walker A/P-loop; other site 573413004589 ATP binding site [chemical binding]; other site 573413004590 Q-loop/lid; other site 573413004591 ABC transporter signature motif; other site 573413004592 Walker B; other site 573413004593 D-loop; other site 573413004594 H-loop/switch region; other site 573413004595 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 573413004596 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413004597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004598 active site 573413004599 phosphorylation site [posttranslational modification] 573413004600 intermolecular recognition site; other site 573413004601 dimerization interface [polypeptide binding]; other site 573413004602 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413004603 DNA binding site [nucleotide binding] 573413004604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413004605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413004606 dimer interface [polypeptide binding]; other site 573413004607 phosphorylation site [posttranslational modification] 573413004608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004609 ATP binding site [chemical binding]; other site 573413004610 Mg2+ binding site [ion binding]; other site 573413004611 G-X-G motif; other site 573413004612 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413004613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004614 active site 573413004615 phosphorylation site [posttranslational modification] 573413004616 intermolecular recognition site; other site 573413004617 dimerization interface [polypeptide binding]; other site 573413004618 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413004619 intersubunit interface [polypeptide binding]; other site 573413004620 active site 573413004621 zinc binding site [ion binding]; other site 573413004622 Na+ binding site [ion binding]; other site 573413004623 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413004624 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413004625 substrate binding site [chemical binding]; other site 573413004626 ATP binding site [chemical binding]; other site 573413004627 threonine synthase; Validated; Region: PRK06260 573413004628 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 573413004629 homodimer interface [polypeptide binding]; other site 573413004630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004631 catalytic residue [active] 573413004632 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 573413004633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413004634 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 573413004635 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413004636 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 573413004637 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413004638 active site 573413004639 peptidase; Reviewed; Region: PRK13004 573413004640 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 573413004641 putative metal binding site [ion binding]; other site 573413004642 putative dimer interface [polypeptide binding]; other site 573413004643 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573413004644 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413004645 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413004646 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413004647 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413004648 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 573413004649 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 573413004650 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413004651 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 573413004652 active site 573413004653 putative substrate binding pocket [chemical binding]; other site 573413004654 putative oxidoreductase; Provisional; Region: PRK09799 573413004655 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 573413004656 putative hypoxanthine oxidase; Provisional; Region: PRK09800 573413004657 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413004658 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 573413004659 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413004660 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 573413004661 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573413004662 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573413004663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413004664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413004665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004666 dimer interface [polypeptide binding]; other site 573413004667 conserved gate region; other site 573413004668 putative PBP binding loops; other site 573413004669 ABC-ATPase subunit interface; other site 573413004670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413004671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004672 dimer interface [polypeptide binding]; other site 573413004673 conserved gate region; other site 573413004674 putative PBP binding loops; other site 573413004675 ABC-ATPase subunit interface; other site 573413004676 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 573413004677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413004678 putative DNA binding site [nucleotide binding]; other site 573413004679 putative Zn2+ binding site [ion binding]; other site 573413004680 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413004681 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413004682 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 573413004683 Uncharacterized conserved protein [Function unknown]; Region: COG5476 573413004684 MlrC C-terminus; Region: MlrC_C; pfam07171 573413004685 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 573413004686 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413004687 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 573413004688 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573413004689 active site 573413004690 Sensory domain found in PocR; Region: PocR; pfam10114 573413004691 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 573413004692 PAS fold; Region: PAS_4; pfam08448 573413004693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413004694 Histidine kinase; Region: HisKA_2; pfam07568 573413004695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004696 ATP binding site [chemical binding]; other site 573413004697 Mg2+ binding site [ion binding]; other site 573413004698 G-X-G motif; other site 573413004699 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 573413004700 SurA N-terminal domain; Region: SurA_N_3; cl07813 573413004701 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573413004702 HAMP domain; Region: HAMP; pfam00672 573413004703 dimerization interface [polypeptide binding]; other site 573413004704 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413004705 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413004706 dimer interface [polypeptide binding]; other site 573413004707 putative CheW interface [polypeptide binding]; other site 573413004708 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413004709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573413004710 catalytic residues [active] 573413004711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413004712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413004713 Response regulator receiver domain; Region: Response_reg; pfam00072 573413004714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004715 active site 573413004716 phosphorylation site [posttranslational modification] 573413004717 intermolecular recognition site; other site 573413004718 dimerization interface [polypeptide binding]; other site 573413004719 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573413004720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004721 ATP binding site [chemical binding]; other site 573413004722 Mg2+ binding site [ion binding]; other site 573413004723 G-X-G motif; other site 573413004724 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573413004725 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573413004726 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573413004727 N-acetylglutamate synthase; Validated; Region: PRK05279 573413004728 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573413004729 nucleotide binding site [chemical binding]; other site 573413004730 substrate binding site [chemical binding]; other site 573413004731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413004732 Coenzyme A binding pocket [chemical binding]; other site 573413004733 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413004734 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413004735 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413004736 Walker A/P-loop; other site 573413004737 ATP binding site [chemical binding]; other site 573413004738 Q-loop/lid; other site 573413004739 ABC transporter signature motif; other site 573413004740 Walker B; other site 573413004741 D-loop; other site 573413004742 H-loop/switch region; other site 573413004743 BioY family; Region: BioY; pfam02632 573413004744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413004745 putative DNA binding site [nucleotide binding]; other site 573413004746 dimerization interface [polypeptide binding]; other site 573413004747 putative Zn2+ binding site [ion binding]; other site 573413004748 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573413004749 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573413004750 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 573413004751 Response regulator receiver domain; Region: Response_reg; pfam00072 573413004752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004753 active site 573413004754 phosphorylation site [posttranslational modification] 573413004755 intermolecular recognition site; other site 573413004756 dimerization interface [polypeptide binding]; other site 573413004757 PAS domain; Region: PAS; smart00091 573413004758 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573413004759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413004760 dimer interface [polypeptide binding]; other site 573413004761 phosphorylation site [posttranslational modification] 573413004762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413004763 ATP binding site [chemical binding]; other site 573413004764 Mg2+ binding site [ion binding]; other site 573413004765 G-X-G motif; other site 573413004766 Response regulator receiver domain; Region: Response_reg; pfam00072 573413004767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004768 active site 573413004769 phosphorylation site [posttranslational modification] 573413004770 intermolecular recognition site; other site 573413004771 dimerization interface [polypeptide binding]; other site 573413004772 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573413004773 trimerization site [polypeptide binding]; other site 573413004774 active site 573413004775 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573413004776 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573413004777 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413004778 catalytic residue [active] 573413004779 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 573413004780 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573413004781 homodimer interface [polypeptide binding]; other site 573413004782 substrate-cofactor binding pocket; other site 573413004783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004784 catalytic residue [active] 573413004785 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 573413004786 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 573413004787 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 573413004788 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413004789 active site 573413004790 putative substrate binding pocket [chemical binding]; other site 573413004791 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 573413004792 Isochorismatase family; Region: Isochorismatase; pfam00857 573413004793 catalytic triad [active] 573413004794 metal binding site [ion binding]; metal-binding site 573413004795 conserved cis-peptide bond; other site 573413004796 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 573413004797 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 573413004798 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 573413004799 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573413004800 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 573413004801 putative active site [active] 573413004802 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 573413004803 MarC family integral membrane protein; Region: MarC; cl00919 573413004804 GAF domain; Region: GAF; pfam01590 573413004805 GAF domain; Region: GAF_2; pfam13185 573413004806 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413004807 Zn2+ binding site [ion binding]; other site 573413004808 Mg2+ binding site [ion binding]; other site 573413004809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413004810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413004811 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413004812 bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376 573413004813 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573413004814 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573413004815 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 573413004816 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 573413004817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413004818 active site 573413004819 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413004820 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413004821 phosphate binding site [ion binding]; other site 573413004822 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 573413004823 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573413004824 FAD binding pocket [chemical binding]; other site 573413004825 conserved FAD binding motif [chemical binding]; other site 573413004826 phosphate binding motif [ion binding]; other site 573413004827 beta-alpha-beta structure motif; other site 573413004828 NAD binding pocket [chemical binding]; other site 573413004829 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413004830 active site 573413004831 Amidohydrolase; Region: Amidohydro_4; pfam13147 573413004832 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413004833 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413004834 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573413004835 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 573413004836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413004837 active site 573413004838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573413004839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413004840 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573413004841 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 573413004842 active site 573413004843 catalytic triad [active] 573413004844 dimer interface [polypeptide binding]; other site 573413004845 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413004846 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 573413004847 putative active site [active] 573413004848 metal binding site [ion binding]; metal-binding site 573413004849 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 573413004850 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573413004851 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573413004852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004853 catalytic residue [active] 573413004854 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 573413004855 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573413004856 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573413004857 Tetramer interface [polypeptide binding]; other site 573413004858 active site 573413004859 FMN-binding site [chemical binding]; other site 573413004860 shikimate kinase; Reviewed; Region: aroK; PRK00131 573413004861 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573413004862 active site 573413004863 fumarate hydratase; Reviewed; Region: fumC; PRK00485 573413004864 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 573413004865 tetramer interface [polypeptide binding]; other site 573413004866 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413004868 active site 573413004869 phosphorylation site [posttranslational modification] 573413004870 intermolecular recognition site; other site 573413004871 dimerization interface [polypeptide binding]; other site 573413004872 PAS fold; Region: PAS; pfam00989 573413004873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413004874 putative active site [active] 573413004875 heme pocket [chemical binding]; other site 573413004876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413004877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413004878 metal binding site [ion binding]; metal-binding site 573413004879 active site 573413004880 I-site; other site 573413004881 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573413004882 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 573413004883 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 573413004884 active site 573413004885 metal binding site [ion binding]; metal-binding site 573413004886 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 573413004887 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413004888 Zn2+ binding site [ion binding]; other site 573413004889 Mg2+ binding site [ion binding]; other site 573413004890 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 573413004891 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413004892 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413004893 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 573413004894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413004895 FeS/SAM binding site; other site 573413004896 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 573413004897 ATP cone domain; Region: ATP-cone; pfam03477 573413004898 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573413004899 effector binding site; other site 573413004900 active site 573413004901 Zn binding site [ion binding]; other site 573413004902 glycine loop; other site 573413004903 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413004904 catalytic residues [active] 573413004905 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 573413004906 ATP cone domain; Region: ATP-cone; pfam03477 573413004907 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 573413004908 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 573413004909 Bacterial Ig-like domain; Region: Big_5; pfam13205 573413004910 MG2 domain; Region: A2M_N; pfam01835 573413004911 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 573413004912 Alpha-2-macroglobulin family; Region: A2M; pfam00207 573413004913 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 573413004914 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 573413004915 Transglycosylase; Region: Transgly; pfam00912 573413004916 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573413004917 DNA methylase; Region: N6_N4_Mtase; pfam01555 573413004918 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573413004919 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 573413004920 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 573413004921 active site 573413004922 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413004923 substrate binding site [chemical binding]; other site 573413004924 catalytic residues [active] 573413004925 dimer interface [polypeptide binding]; other site 573413004926 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 573413004927 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413004928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413004929 homodimer interface [polypeptide binding]; other site 573413004930 catalytic residue [active] 573413004931 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573413004932 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573413004933 dimer interface [polypeptide binding]; other site 573413004934 active site 573413004935 catalytic residue [active] 573413004936 aspartate kinase, monofunctional class; Region: asp_kin_monofn; TIGR00656 573413004937 NTPase; Region: NTPase_1; cl17478 573413004938 LPP20 lipoprotein; Region: LPP20; pfam02169 573413004939 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573413004940 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 573413004941 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 573413004942 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573413004943 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 573413004944 active site 573413004945 substrate binding site [chemical binding]; other site 573413004946 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 573413004947 FMN binding site [chemical binding]; other site 573413004948 putative catalytic residues [active] 573413004949 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573413004950 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573413004951 catalytic residues [active] 573413004952 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 573413004953 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573413004954 metal-binding site [ion binding] 573413004955 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 573413004956 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 573413004957 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 573413004958 active site 573413004959 substrate binding site [chemical binding]; other site 573413004960 metal binding site [ion binding]; metal-binding site 573413004961 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 573413004962 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573413004963 Amidohydrolase; Region: Amidohydro_2; pfam04909 573413004964 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 573413004965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413004966 active site 573413004967 HIGH motif; other site 573413004968 nucleotide binding site [chemical binding]; other site 573413004969 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 573413004970 KMSKS motif; other site 573413004971 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 573413004972 GAF domain; Region: GAF_3; pfam13492 573413004973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413004974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413004975 metal binding site [ion binding]; metal-binding site 573413004976 active site 573413004977 I-site; other site 573413004978 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 573413004979 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413004980 Walker A/P-loop; other site 573413004981 ATP binding site [chemical binding]; other site 573413004982 Q-loop/lid; other site 573413004983 ABC transporter signature motif; other site 573413004984 Walker B; other site 573413004985 D-loop; other site 573413004986 H-loop/switch region; other site 573413004987 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 573413004988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413004989 Walker A/P-loop; other site 573413004990 ATP binding site [chemical binding]; other site 573413004991 Q-loop/lid; other site 573413004992 ABC transporter signature motif; other site 573413004993 Walker B; other site 573413004994 D-loop; other site 573413004995 H-loop/switch region; other site 573413004996 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 573413004997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413004998 dimer interface [polypeptide binding]; other site 573413004999 conserved gate region; other site 573413005000 putative PBP binding loops; other site 573413005001 ABC-ATPase subunit interface; other site 573413005002 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 573413005003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005004 dimer interface [polypeptide binding]; other site 573413005005 conserved gate region; other site 573413005006 putative PBP binding loops; other site 573413005007 ABC-ATPase subunit interface; other site 573413005008 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 573413005009 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 573413005010 PAS domain; Region: PAS_9; pfam13426 573413005011 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413005012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413005013 Histidine kinase; Region: HisKA_2; pfam07568 573413005014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005015 ATP binding site [chemical binding]; other site 573413005016 Mg2+ binding site [ion binding]; other site 573413005017 G-X-G motif; other site 573413005018 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413005019 EamA-like transporter family; Region: EamA; cl17759 573413005020 histidinol-phosphatase; Provisional; Region: PRK07328 573413005021 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 573413005022 active site 573413005023 Trp repressor protein; Region: Trp_repressor; cl17266 573413005024 Esterase/lipase [General function prediction only]; Region: COG1647 573413005025 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573413005026 Na binding site [ion binding]; other site 573413005027 TIR domain; Region: TIR_2; cl17458 573413005028 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 573413005029 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 573413005030 Uncharacterized protein family (UPF0164); Region: UPF0164; pfam03687 573413005031 TPR repeat; Region: TPR_11; pfam13414 573413005032 Tetratricopeptide repeat; Region: TPR_2; pfam07719 573413005033 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 573413005034 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 573413005035 Double zinc ribbon; Region: DZR; pfam12773 573413005036 Sugar fermentation stimulation protein; Region: SfsA; cl00647 573413005037 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573413005038 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573413005039 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413005040 acyl-activating enzyme (AAE) consensus motif; other site 573413005041 acyl-activating enzyme (AAE) consensus motif; other site 573413005042 putative AMP binding site [chemical binding]; other site 573413005043 putative active site [active] 573413005044 putative CoA binding site [chemical binding]; other site 573413005045 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 573413005046 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 573413005047 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573413005048 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 573413005049 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573413005050 catalytic residues [active] 573413005051 CAAX protease self-immunity; Region: Abi; pfam02517 573413005052 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 573413005053 PilZ domain; Region: PilZ; pfam07238 573413005054 Competence protein; Region: Competence; pfam03772 573413005055 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573413005056 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 573413005057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 573413005058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413005059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413005060 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 573413005061 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 573413005062 arogenate dehydrogenase; Region: PLN02256 573413005063 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 573413005064 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573413005065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413005066 TPR motif; other site 573413005067 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413005068 binding surface 573413005069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413005070 TPR motif; other site 573413005071 binding surface 573413005072 TPR repeat; Region: TPR_11; pfam13414 573413005073 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573413005074 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 573413005075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413005076 FeS/SAM binding site; other site 573413005077 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413005078 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413005079 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 573413005080 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 573413005081 DctM-like transporters; Region: DctM; pfam06808 573413005082 TIGR04076 family protein; Region: TIGR04076 573413005083 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573413005084 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 573413005085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413005086 active site 573413005087 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413005088 binding surface 573413005089 TPR motif; other site 573413005090 adenylate kinase; Reviewed; Region: adk; PRK00279 573413005091 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573413005092 AMP-binding site [chemical binding]; other site 573413005093 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573413005094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573413005095 Ligand Binding Site [chemical binding]; other site 573413005096 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573413005097 Ligand Binding Site [chemical binding]; other site 573413005098 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573413005099 putative CheA interaction surface; other site 573413005100 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 573413005101 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413005102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413005103 catalytic residue [active] 573413005104 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 573413005105 ATP-NAD kinase; Region: NAD_kinase; pfam01513 573413005106 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573413005107 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573413005108 Walker A/P-loop; other site 573413005109 ATP binding site [chemical binding]; other site 573413005110 Q-loop/lid; other site 573413005111 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573413005112 ABC transporter signature motif; other site 573413005113 Walker B; other site 573413005114 D-loop; other site 573413005115 H-loop/switch region; other site 573413005116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413005118 S-adenosylmethionine binding site [chemical binding]; other site 573413005119 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 573413005120 active site 573413005121 catalytic site [active] 573413005122 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 573413005123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 573413005124 Uncharacterized conserved protein [Function unknown]; Region: COG1543 573413005125 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 573413005126 active site 573413005127 substrate binding site [chemical binding]; other site 573413005128 catalytic site [active] 573413005129 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 573413005130 cell division protein MraZ; Reviewed; Region: PRK00326 573413005131 MraZ protein; Region: MraZ; pfam02381 573413005132 MraZ protein; Region: MraZ; pfam02381 573413005133 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 573413005134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413005135 S-adenosylmethionine binding site [chemical binding]; other site 573413005136 Cell division protein FtsL; Region: FtsL; cl11433 573413005137 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573413005138 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 573413005139 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573413005140 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573413005141 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573413005142 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573413005143 Mg++ binding site [ion binding]; other site 573413005144 putative catalytic motif [active] 573413005145 putative substrate binding site [chemical binding]; other site 573413005146 cell division protein FtsW; Region: ftsW; TIGR02614 573413005147 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573413005148 cell division protein FtsA; Region: ftsA; TIGR01174 573413005149 Cell division protein FtsA; Region: FtsA; smart00842 573413005150 Cell division protein FtsA; Region: FtsA; pfam14450 573413005151 cell division protein FtsZ; Validated; Region: PRK09330 573413005152 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573413005153 nucleotide binding site [chemical binding]; other site 573413005154 SulA interaction site; other site 573413005155 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 573413005156 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573413005157 active site 573413005158 Int/Topo IB signature motif; other site 573413005159 TPR repeat; Region: TPR_11; pfam13414 573413005160 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 573413005161 DNA protecting protein DprA; Region: dprA; TIGR00732 573413005162 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573413005163 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 573413005164 active site 573413005165 DNA binding site [nucleotide binding] 573413005166 Int/Topo IB signature motif; other site 573413005167 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 573413005168 active site 573413005169 HslU subunit interaction site [polypeptide binding]; other site 573413005170 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 573413005171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413005172 Walker A motif; other site 573413005173 ATP binding site [chemical binding]; other site 573413005174 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 573413005175 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573413005176 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12622 573413005177 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 573413005178 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 573413005179 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573413005180 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573413005181 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 573413005182 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 573413005183 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 573413005184 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 573413005185 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 573413005186 FliG C-terminal domain; Region: FliG_C; pfam01706 573413005187 flagellar assembly protein H; Validated; Region: fliH; PRK06669 573413005188 Flagellar assembly protein FliH; Region: FliH; pfam02108 573413005189 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 573413005190 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573413005191 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 573413005192 Walker A motif/ATP binding site; other site 573413005193 Walker B motif; other site 573413005194 phosphodiesterase; Provisional; Region: PRK12704 573413005195 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 573413005196 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 573413005197 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 573413005198 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 573413005199 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573413005200 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 573413005201 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573413005202 Flagellar protein (FlbD); Region: FlbD; pfam06289 573413005203 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 573413005204 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 573413005205 flagellar motor protein MotB; Validated; Region: motB; PRK06667 573413005206 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 573413005207 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413005208 ligand binding site [chemical binding]; other site 573413005209 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK06654 573413005210 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 573413005211 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 573413005212 flagellar motor switch protein; Validated; Region: PRK08119 573413005213 Chemotaxis phosphatase CheX; Region: CheX; cl15816 573413005214 flagellar motor switch protein FliN; Region: fliN; TIGR02480 573413005215 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 573413005216 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 573413005217 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 573413005218 flagellar biosynthetic protein FliR; Region: fliR; TIGR01400 573413005219 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 573413005220 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573413005221 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 573413005222 FHIPEP family; Region: FHIPEP; pfam00771 573413005223 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 573413005224 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413005225 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573413005226 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573413005227 P-loop; other site 573413005228 Nop14-like family; Region: Nop14; pfam04147 573413005229 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 573413005230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413005231 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573413005232 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413005233 DNA binding residues [nucleotide binding] 573413005234 Protein of unknown function (DUF342); Region: DUF342; pfam03961 573413005235 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 573413005236 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 573413005237 nucleotide binding site [chemical binding]; other site 573413005238 putative NEF/HSP70 interaction site [polypeptide binding]; other site 573413005239 SBD interface [polypeptide binding]; other site 573413005240 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413005241 HSP70 interaction site [polypeptide binding]; other site 573413005242 HEAT repeats; Region: HEAT_2; pfam13646 573413005243 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413005244 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573413005245 putative binding surface; other site 573413005246 active site 573413005247 P2 response regulator binding domain; Region: P2; pfam07194 573413005248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005249 ATP binding site [chemical binding]; other site 573413005250 Mg2+ binding site [ion binding]; other site 573413005251 G-X-G motif; other site 573413005252 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573413005253 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005255 ABC transporter; Region: ABC_tran_2; pfam12848 573413005256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005257 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413005258 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 573413005259 putative substrate binding site [chemical binding]; other site 573413005260 putative ATP binding site [chemical binding]; other site 573413005261 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 573413005262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 573413005263 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413005264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413005265 dimer interface [polypeptide binding]; other site 573413005266 putative CheW interface [polypeptide binding]; other site 573413005267 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573413005268 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573413005269 substrate binding pocket [chemical binding]; other site 573413005270 chain length determination region; other site 573413005271 substrate-Mg2+ binding site; other site 573413005272 catalytic residues [active] 573413005273 aspartate-rich region 1; other site 573413005274 active site lid residues [active] 573413005275 aspartate-rich region 2; other site 573413005276 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 573413005277 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413005278 Predicted membrane protein [Function unknown]; Region: COG2259 573413005279 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 573413005280 ApbE family; Region: ApbE; pfam02424 573413005281 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 573413005282 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 573413005283 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573413005284 PYR/PP interface [polypeptide binding]; other site 573413005285 dimer interface [polypeptide binding]; other site 573413005286 TPP binding site [chemical binding]; other site 573413005287 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573413005288 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573413005289 TPP-binding site [chemical binding]; other site 573413005290 dimer interface [polypeptide binding]; other site 573413005291 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573413005292 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573413005293 putative valine binding site [chemical binding]; other site 573413005294 dimer interface [polypeptide binding]; other site 573413005295 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573413005296 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573413005297 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573413005298 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573413005299 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 573413005300 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 573413005301 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 573413005302 active site 573413005303 catalytic residues [active] 573413005304 metal binding site [ion binding]; metal-binding site 573413005305 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573413005306 2-isopropylmalate synthase; Validated; Region: PRK00915 573413005307 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 573413005308 active site 573413005309 catalytic residues [active] 573413005310 metal binding site [ion binding]; metal-binding site 573413005311 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 573413005312 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573413005313 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573413005314 substrate binding site [chemical binding]; other site 573413005315 ligand binding site [chemical binding]; other site 573413005316 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 573413005317 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573413005318 substrate binding site [chemical binding]; other site 573413005319 tartrate dehydrogenase; Region: TTC; TIGR02089 573413005320 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 573413005321 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413005322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413005323 putative active site [active] 573413005324 heme pocket [chemical binding]; other site 573413005325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413005326 dimer interface [polypeptide binding]; other site 573413005327 phosphorylation site [posttranslational modification] 573413005328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005329 ATP binding site [chemical binding]; other site 573413005330 Mg2+ binding site [ion binding]; other site 573413005331 G-X-G motif; other site 573413005332 Response regulator receiver domain; Region: Response_reg; pfam00072 573413005333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005334 active site 573413005335 phosphorylation site [posttranslational modification] 573413005336 intermolecular recognition site; other site 573413005337 dimerization interface [polypeptide binding]; other site 573413005338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413005339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005340 ATP binding site [chemical binding]; other site 573413005341 Mg2+ binding site [ion binding]; other site 573413005342 G-X-G motif; other site 573413005343 Response regulator receiver domain; Region: Response_reg; pfam00072 573413005344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005345 active site 573413005346 phosphorylation site [posttranslational modification] 573413005347 intermolecular recognition site; other site 573413005348 dimerization interface [polypeptide binding]; other site 573413005349 Protein of unknown function (DUF342); Region: DUF342; pfam03961 573413005350 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 573413005351 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413005352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413005353 DNA-binding site [nucleotide binding]; DNA binding site 573413005354 UTRA domain; Region: UTRA; pfam07702 573413005355 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413005356 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413005357 nucleotide binding site [chemical binding]; other site 573413005358 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 573413005359 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573413005360 putative active site; other site 573413005361 catalytic residue [active] 573413005362 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413005363 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413005364 NAD(P) binding site [chemical binding]; other site 573413005365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413005366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005368 dimer interface [polypeptide binding]; other site 573413005369 conserved gate region; other site 573413005370 putative PBP binding loops; other site 573413005371 ABC-ATPase subunit interface; other site 573413005372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005374 dimer interface [polypeptide binding]; other site 573413005375 conserved gate region; other site 573413005376 putative PBP binding loops; other site 573413005377 ABC-ATPase subunit interface; other site 573413005378 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 573413005379 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573413005380 dimer interface [polypeptide binding]; other site 573413005381 putative functional site; other site 573413005382 putative MPT binding site; other site 573413005383 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 573413005384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413005385 FeS/SAM binding site; other site 573413005386 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 573413005387 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cd00528 573413005388 trimer interface [polypeptide binding]; other site 573413005389 dimer interface [polypeptide binding]; other site 573413005390 putative active site [active] 573413005391 MOSC domain; Region: MOSC; pfam03473 573413005392 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 573413005393 MPT binding site; other site 573413005394 trimer interface [polypeptide binding]; other site 573413005395 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573413005396 catalytic core [active] 573413005397 cobalamin synthase; Reviewed; Region: cobS; PRK00235 573413005398 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 573413005399 homotrimer interface [polypeptide binding]; other site 573413005400 Walker A motif; other site 573413005401 GTP binding site [chemical binding]; other site 573413005402 Walker B motif; other site 573413005403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413005404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413005405 TM-ABC transporter signature motif; other site 573413005406 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573413005407 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413005408 Walker A/P-loop; other site 573413005409 ATP binding site [chemical binding]; other site 573413005410 Q-loop/lid; other site 573413005411 ABC transporter signature motif; other site 573413005412 Walker B; other site 573413005413 D-loop; other site 573413005414 H-loop/switch region; other site 573413005415 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413005416 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 573413005417 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413005418 putative ligand binding site [chemical binding]; other site 573413005419 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413005420 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413005421 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413005422 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413005423 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413005424 Walker A/P-loop; other site 573413005425 ATP binding site [chemical binding]; other site 573413005426 Q-loop/lid; other site 573413005427 ABC transporter signature motif; other site 573413005428 Walker B; other site 573413005429 D-loop; other site 573413005430 H-loop/switch region; other site 573413005431 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413005432 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 573413005433 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 573413005434 FAD binding pocket [chemical binding]; other site 573413005435 FAD binding motif [chemical binding]; other site 573413005436 phosphate binding motif [ion binding]; other site 573413005437 beta-alpha-beta structure motif; other site 573413005438 NAD binding pocket [chemical binding]; other site 573413005439 Iron coordination center [ion binding]; other site 573413005440 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 573413005441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413005442 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413005443 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413005444 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413005445 active site 573413005446 phosphorylation site [posttranslational modification] 573413005447 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 573413005448 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 573413005449 TRAM domain; Region: TRAM; cl01282 573413005450 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573413005451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413005452 S-adenosylmethionine binding site [chemical binding]; other site 573413005453 glycerol kinase; Provisional; Region: glpK; PRK00047 573413005454 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413005455 nucleotide binding site [chemical binding]; other site 573413005456 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 573413005457 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 573413005458 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 573413005459 putative active site [active] 573413005460 catalytic site [active] 573413005461 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 573413005462 putative active site [active] 573413005463 catalytic site [active] 573413005464 TIGR00159 family protein; Region: TIGR00159 573413005465 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 573413005466 YbbR-like protein; Region: YbbR; pfam07949 573413005467 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 573413005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 573413005469 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 573413005470 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 573413005471 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573413005472 dimerization interface 3.5A [polypeptide binding]; other site 573413005473 active site 573413005474 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 573413005475 Fe-S cluster binding site [ion binding]; other site 573413005476 active site 573413005477 primosome assembly protein PriA; Validated; Region: PRK05580 573413005478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413005479 ATP binding site [chemical binding]; other site 573413005480 putative Mg++ binding site [ion binding]; other site 573413005481 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 573413005482 phosphatidylinositol 3-phosphate binding site [chemical binding]; other site 573413005483 Zn binding sites [ion binding]; other site 573413005484 helicase superfamily c-terminal domain; Region: HELICc; smart00490 573413005485 ATP-binding site [chemical binding]; other site 573413005486 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573413005487 active site 573413005488 catalytic residues [active] 573413005489 metal binding site [ion binding]; metal-binding site 573413005490 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573413005491 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573413005492 putative active site [active] 573413005493 substrate binding site [chemical binding]; other site 573413005494 putative cosubstrate binding site; other site 573413005495 catalytic site [active] 573413005496 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573413005497 substrate binding site [chemical binding]; other site 573413005498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 573413005499 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573413005500 PASTA domain; Region: PASTA; pfam03793 573413005501 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573413005502 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005504 dimer interface [polypeptide binding]; other site 573413005505 conserved gate region; other site 573413005506 putative PBP binding loops; other site 573413005507 ABC-ATPase subunit interface; other site 573413005508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005509 dimer interface [polypeptide binding]; other site 573413005510 conserved gate region; other site 573413005511 putative PBP binding loops; other site 573413005512 ABC-ATPase subunit interface; other site 573413005513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413005514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413005515 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573413005516 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573413005517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 573413005518 Propionate catabolism activator; Region: PrpR_N; pfam06506 573413005519 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 573413005520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413005521 Walker A motif; other site 573413005522 ATP binding site [chemical binding]; other site 573413005523 Walker B motif; other site 573413005524 arginine finger; other site 573413005525 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573413005526 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413005527 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413005528 Walker A/P-loop; other site 573413005529 ATP binding site [chemical binding]; other site 573413005530 Q-loop/lid; other site 573413005531 ABC transporter signature motif; other site 573413005532 Walker B; other site 573413005533 D-loop; other site 573413005534 H-loop/switch region; other site 573413005535 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413005536 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413005537 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413005538 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413005539 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413005540 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413005541 TM-ABC transporter signature motif; other site 573413005542 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413005543 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413005544 Propionate catabolism activator; Region: PrpR_N; pfam06506 573413005545 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 573413005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413005547 Walker A motif; other site 573413005548 ATP binding site [chemical binding]; other site 573413005549 Walker B motif; other site 573413005550 arginine finger; other site 573413005551 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413005552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 573413005553 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 573413005554 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413005555 putative active site [active] 573413005556 metal binding site [ion binding]; metal-binding site 573413005557 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 573413005558 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 573413005559 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413005560 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 573413005561 inhibitor site; inhibition site 573413005562 active site 573413005563 dimer interface [polypeptide binding]; other site 573413005564 catalytic residue [active] 573413005565 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413005566 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 573413005567 ligand binding site [chemical binding]; other site 573413005568 NAD binding site [chemical binding]; other site 573413005569 dimerization interface [polypeptide binding]; other site 573413005570 catalytic site [active] 573413005571 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 573413005572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413005573 active site 573413005574 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413005575 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 573413005576 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 573413005577 DctM-like transporters; Region: DctM; pfam06808 573413005578 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573413005579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413005580 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 573413005581 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573413005582 active site 573413005583 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 573413005584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413005585 putative ADP-binding pocket [chemical binding]; other site 573413005586 Domain of unknown function (DUF386); Region: DUF386; cl01047 573413005587 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 573413005588 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 573413005589 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869 573413005590 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573413005591 serine O-acetyltransferase; Region: cysE; TIGR01172 573413005592 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 573413005593 trimer interface [polypeptide binding]; other site 573413005594 active site 573413005595 substrate binding site [chemical binding]; other site 573413005596 CoA binding site [chemical binding]; other site 573413005597 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573413005598 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573413005599 putative dimer interface [polypeptide binding]; other site 573413005600 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573413005601 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573413005602 putative dimer interface [polypeptide binding]; other site 573413005603 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 573413005604 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573413005605 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573413005606 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573413005607 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573413005608 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 573413005609 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573413005610 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 573413005611 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 573413005612 CoA binding domain; Region: CoA_binding; pfam02629 573413005613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573413005614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573413005615 active site 573413005616 ATP binding site [chemical binding]; other site 573413005617 substrate binding site [chemical binding]; other site 573413005618 activation loop (A-loop); other site 573413005619 Predicted ATPase [General function prediction only]; Region: COG3899 573413005620 AAA ATPase domain; Region: AAA_16; pfam13191 573413005621 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413005622 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413005623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413005624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413005625 dimer interface [polypeptide binding]; other site 573413005626 phosphorylation site [posttranslational modification] 573413005627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005628 ATP binding site [chemical binding]; other site 573413005629 Mg2+ binding site [ion binding]; other site 573413005630 G-X-G motif; other site 573413005631 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413005632 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005634 active site 573413005635 phosphorylation site [posttranslational modification] 573413005636 intermolecular recognition site; other site 573413005637 dimerization interface [polypeptide binding]; other site 573413005638 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413005639 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413005640 metal binding site [ion binding]; metal-binding site 573413005641 active site 573413005642 I-site; other site 573413005643 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413005644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413005645 Walker A/P-loop; other site 573413005646 ATP binding site [chemical binding]; other site 573413005647 Q-loop/lid; other site 573413005648 ABC transporter signature motif; other site 573413005649 Walker B; other site 573413005650 D-loop; other site 573413005651 H-loop/switch region; other site 573413005652 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413005653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005654 dimer interface [polypeptide binding]; other site 573413005655 conserved gate region; other site 573413005656 putative PBP binding loops; other site 573413005657 ABC-ATPase subunit interface; other site 573413005658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005659 dimer interface [polypeptide binding]; other site 573413005660 conserved gate region; other site 573413005661 putative PBP binding loops; other site 573413005662 ABC-ATPase subunit interface; other site 573413005663 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 573413005664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413005665 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573413005666 dimerization interface [polypeptide binding]; other site 573413005667 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413005668 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413005669 putative active site [active] 573413005670 heme pocket [chemical binding]; other site 573413005671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413005672 dimer interface [polypeptide binding]; other site 573413005673 phosphorylation site [posttranslational modification] 573413005674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005675 ATP binding site [chemical binding]; other site 573413005676 Mg2+ binding site [ion binding]; other site 573413005677 G-X-G motif; other site 573413005678 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413005679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005680 active site 573413005681 phosphorylation site [posttranslational modification] 573413005682 intermolecular recognition site; other site 573413005683 dimerization interface [polypeptide binding]; other site 573413005684 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413005685 DNA binding site [nucleotide binding] 573413005686 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573413005687 PhoU domain; Region: PhoU; pfam01895 573413005688 PhoU domain; Region: PhoU; pfam01895 573413005689 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 573413005690 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573413005691 Walker A/P-loop; other site 573413005692 ATP binding site [chemical binding]; other site 573413005693 Q-loop/lid; other site 573413005694 ABC transporter signature motif; other site 573413005695 Walker B; other site 573413005696 D-loop; other site 573413005697 H-loop/switch region; other site 573413005698 PBP superfamily domain; Region: PBP_like_2; cl17296 573413005699 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 573413005700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005701 dimer interface [polypeptide binding]; other site 573413005702 conserved gate region; other site 573413005703 putative PBP binding loops; other site 573413005704 ABC-ATPase subunit interface; other site 573413005705 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 573413005706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005707 dimer interface [polypeptide binding]; other site 573413005708 conserved gate region; other site 573413005709 putative PBP binding loops; other site 573413005710 ABC-ATPase subunit interface; other site 573413005711 PBP superfamily domain; Region: PBP_like_2; cl17296 573413005712 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573413005713 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573413005714 active site 573413005715 homodimer interface [polypeptide binding]; other site 573413005716 Colicin V production protein; Region: Colicin_V; pfam02674 573413005717 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 573413005718 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573413005719 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573413005720 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413005721 putative active site [active] 573413005722 heme pocket [chemical binding]; other site 573413005723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413005724 dimer interface [polypeptide binding]; other site 573413005725 phosphorylation site [posttranslational modification] 573413005726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005727 ATP binding site [chemical binding]; other site 573413005728 Mg2+ binding site [ion binding]; other site 573413005729 G-X-G motif; other site 573413005730 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573413005731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005732 active site 573413005733 phosphorylation site [posttranslational modification] 573413005734 intermolecular recognition site; other site 573413005735 dimerization interface [polypeptide binding]; other site 573413005736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413005737 Walker A motif; other site 573413005738 ATP binding site [chemical binding]; other site 573413005739 Walker B motif; other site 573413005740 arginine finger; other site 573413005741 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413005742 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413005743 HSP70 interaction site [polypeptide binding]; other site 573413005744 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 573413005745 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 573413005746 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 573413005747 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 573413005748 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573413005749 oligomerisation interface [polypeptide binding]; other site 573413005750 mobile loop; other site 573413005751 roof hairpin; other site 573413005752 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573413005753 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 573413005754 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413005755 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573413005756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413005757 DNA binding residues [nucleotide binding] 573413005758 pyruvate phosphate dikinase; Provisional; Region: PRK09279 573413005759 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573413005760 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573413005761 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413005762 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413005763 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 573413005764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573413005765 minor groove reading motif; other site 573413005766 helix-hairpin-helix signature motif; other site 573413005767 substrate binding pocket [chemical binding]; other site 573413005768 active site 573413005769 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 573413005770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005772 ABC transporter; Region: ABC_tran_2; pfam12848 573413005773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413005774 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 573413005775 Flavoprotein; Region: Flavoprotein; pfam02441 573413005776 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 573413005777 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 573413005778 L-tyrosine decarboxylase; Provisional; Region: PRK13520 573413005779 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413005780 catalytic residue [active] 573413005781 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 573413005782 oligomerization interface [polypeptide binding]; other site 573413005783 active site 573413005784 metal binding site [ion binding]; metal-binding site 573413005785 hypothetical protein; Provisional; Region: PRK13761 573413005786 Predicted archaeal kinase (sugar kinase superfamily) [General function prediction only]; Region: COG1829 573413005787 PQQ-like domain; Region: PQQ_2; pfam13360 573413005788 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 573413005789 active site 573413005790 HEAT repeats; Region: HEAT_2; pfam13646 573413005791 Borrelia P83/100 protein; Region: Borrelia_P83; pfam05262 573413005792 ParB-like nuclease domain; Region: ParB; smart00470 573413005793 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 573413005794 Transglycosylase; Region: Transgly; pfam00912 573413005795 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573413005796 PEGA domain; Region: PEGA; pfam08308 573413005797 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413005798 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413005799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413005800 TPR motif; other site 573413005801 binding surface 573413005802 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573413005803 mce related protein; Region: MCE; pfam02470 573413005804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413005805 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 573413005806 Walker A/P-loop; other site 573413005807 ATP binding site [chemical binding]; other site 573413005808 Q-loop/lid; other site 573413005809 ABC transporter signature motif; other site 573413005810 Walker B; other site 573413005811 D-loop; other site 573413005812 H-loop/switch region; other site 573413005813 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573413005814 Permease; Region: Permease; pfam02405 573413005815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413005816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413005817 ligand binding site [chemical binding]; other site 573413005818 flexible hinge region; other site 573413005819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413005820 binding surface 573413005821 TPR repeat; Region: TPR_11; pfam13414 573413005822 TPR motif; other site 573413005823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413005824 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413005825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413005826 ligand binding site [chemical binding]; other site 573413005827 flexible hinge region; other site 573413005828 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573413005829 DNA binding site [nucleotide binding] 573413005830 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 573413005831 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573413005832 FCD domain; Region: FCD; pfam07729 573413005833 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 573413005834 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573413005835 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 573413005836 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573413005837 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 573413005838 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 573413005839 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 573413005840 N-terminal plug; other site 573413005841 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413005842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005843 dimer interface [polypeptide binding]; other site 573413005844 conserved gate region; other site 573413005845 putative PBP binding loops; other site 573413005846 ABC-ATPase subunit interface; other site 573413005847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413005848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005849 dimer interface [polypeptide binding]; other site 573413005850 conserved gate region; other site 573413005851 putative PBP binding loops; other site 573413005852 ABC-ATPase subunit interface; other site 573413005853 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413005854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413005855 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413005856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005857 ATP binding site [chemical binding]; other site 573413005858 Mg2+ binding site [ion binding]; other site 573413005859 G-X-G motif; other site 573413005860 transcriptional regulator NarL; Provisional; Region: PRK10651 573413005861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005862 active site 573413005863 phosphorylation site [posttranslational modification] 573413005864 intermolecular recognition site; other site 573413005865 dimerization interface [polypeptide binding]; other site 573413005866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413005867 DNA binding residues [nucleotide binding] 573413005868 dimerization interface [polypeptide binding]; other site 573413005869 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 573413005870 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 573413005871 NAD binding site [chemical binding]; other site 573413005872 homodimer interface [polypeptide binding]; other site 573413005873 active site 573413005874 substrate binding site [chemical binding]; other site 573413005875 Phosphotransferase enzyme family; Region: APH; pfam01636 573413005876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413005877 active site 573413005878 Sensory domain found in PocR; Region: PocR; pfam10114 573413005879 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 573413005880 Helix-turn-helix domain; Region: HTH_18; pfam12833 573413005881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413005882 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413005883 Protein export membrane protein; Region: SecD_SecF; cl14618 573413005884 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413005885 Bacterial Ig-like domain; Region: Big_5; pfam13205 573413005886 Bacterial Ig-like domain; Region: Big_5; pfam13205 573413005887 Bacterial Ig-like domain; Region: Big_5; pfam13205 573413005888 Bacterial Ig-like domain; Region: Big_5; pfam13205 573413005889 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573413005890 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 573413005891 E3 interaction surface; other site 573413005892 lipoyl attachment site [posttranslational modification]; other site 573413005893 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413005894 Outer membrane efflux protein; Region: OEP; pfam02321 573413005895 Outer membrane efflux protein; Region: OEP; pfam02321 573413005896 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413005897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413005898 TPR motif; other site 573413005899 binding surface 573413005900 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 573413005901 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573413005902 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413005903 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413005904 DNA binding site [nucleotide binding] 573413005905 domain linker motif; other site 573413005906 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413005907 dimerization interface [polypeptide binding]; other site 573413005908 ligand binding site [chemical binding]; other site 573413005909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413005910 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413005911 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413005912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005913 dimer interface [polypeptide binding]; other site 573413005914 conserved gate region; other site 573413005915 putative PBP binding loops; other site 573413005916 ABC-ATPase subunit interface; other site 573413005917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413005918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005919 dimer interface [polypeptide binding]; other site 573413005920 conserved gate region; other site 573413005921 putative PBP binding loops; other site 573413005922 ABC-ATPase subunit interface; other site 573413005923 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 573413005924 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573413005925 putative catalytic site [active] 573413005926 putative metal binding site [ion binding]; other site 573413005927 putative phosphate binding site [ion binding]; other site 573413005928 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573413005929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413005930 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413005931 active site 573413005932 catalytic tetrad [active] 573413005933 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 573413005934 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 573413005935 putative active site [active] 573413005936 metal binding site [ion binding]; metal-binding site 573413005937 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573413005938 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 573413005939 DNA binding residues [nucleotide binding] 573413005940 putative dimer interface [polypeptide binding]; other site 573413005941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 573413005942 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413005943 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 573413005944 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413005945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005946 dimer interface [polypeptide binding]; other site 573413005947 conserved gate region; other site 573413005948 putative PBP binding loops; other site 573413005949 ABC-ATPase subunit interface; other site 573413005950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413005951 dimer interface [polypeptide binding]; other site 573413005952 conserved gate region; other site 573413005953 putative PBP binding loops; other site 573413005954 ABC-ATPase subunit interface; other site 573413005955 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 573413005956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413005957 Walker A/P-loop; other site 573413005958 ATP binding site [chemical binding]; other site 573413005959 Q-loop/lid; other site 573413005960 ABC transporter signature motif; other site 573413005961 Walker B; other site 573413005962 D-loop; other site 573413005963 H-loop/switch region; other site 573413005964 TOBE domain; Region: TOBE_2; pfam08402 573413005965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413005967 active site 573413005968 phosphorylation site [posttranslational modification] 573413005969 intermolecular recognition site; other site 573413005970 dimerization interface [polypeptide binding]; other site 573413005971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413005972 DNA binding site [nucleotide binding] 573413005973 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413005974 PAS domain; Region: PAS; smart00091 573413005975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413005976 dimer interface [polypeptide binding]; other site 573413005977 phosphorylation site [posttranslational modification] 573413005978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413005979 ATP binding site [chemical binding]; other site 573413005980 Mg2+ binding site [ion binding]; other site 573413005981 G-X-G motif; other site 573413005982 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 573413005983 active site 573413005984 substrate binding site [chemical binding]; other site 573413005985 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573413005986 metal binding site [ion binding]; metal-binding site 573413005987 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 573413005988 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573413005989 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 573413005990 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816 573413005991 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 573413005992 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573413005993 Flagellar P-ring protein; Region: FlgI; pfam02119 573413005994 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 573413005995 Rod binding protein; Region: Rod-binding; pfam10135 573413005996 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573413005997 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 573413005998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413005999 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573413006000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413006001 DNA binding residues [nucleotide binding] 573413006002 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 573413006003 NodB motif; other site 573413006004 putative active site [active] 573413006005 putative catalytic site [active] 573413006006 Zn binding site [ion binding]; other site 573413006007 UGMP family protein; Validated; Region: PRK09604 573413006008 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573413006009 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 573413006010 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 573413006011 P-loop; other site 573413006012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413006013 active site 573413006014 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573413006015 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 573413006016 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 573413006017 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413006018 active site 573413006019 HIGH motif; other site 573413006020 nucleotide binding site [chemical binding]; other site 573413006021 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573413006022 KMSK motif region; other site 573413006023 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573413006024 tRNA binding surface [nucleotide binding]; other site 573413006025 anticodon binding site; other site 573413006026 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573413006027 Protein of unknown function (DUF464); Region: DUF464; cl01080 573413006028 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573413006029 GTPase CgtA; Reviewed; Region: obgE; PRK12299 573413006030 GTP1/OBG; Region: GTP1_OBG; pfam01018 573413006031 Obg GTPase; Region: Obg; cd01898 573413006032 G1 box; other site 573413006033 GTP/Mg2+ binding site [chemical binding]; other site 573413006034 Switch I region; other site 573413006035 G2 box; other site 573413006036 G3 box; other site 573413006037 Switch II region; other site 573413006038 G4 box; other site 573413006039 G5 box; other site 573413006040 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 573413006041 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573413006042 active site 573413006043 (T/H)XGH motif; other site 573413006044 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413006045 Zn2+ binding site [ion binding]; other site 573413006046 Mg2+ binding site [ion binding]; other site 573413006047 Transcriptional regulator [Transcription]; Region: LytR; COG1316 573413006048 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 573413006049 Oligomerisation domain; Region: Oligomerisation; cl00519 573413006050 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573413006051 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 573413006052 regulatory protein SpoVG; Reviewed; Region: PRK13259 573413006053 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 573413006054 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573413006055 5S rRNA interface [nucleotide binding]; other site 573413006056 CTC domain interface [polypeptide binding]; other site 573413006057 L16 interface [polypeptide binding]; other site 573413006058 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573413006059 putative active site [active] 573413006060 catalytic residue [active] 573413006061 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 573413006062 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573413006063 Ligand Binding Site [chemical binding]; other site 573413006064 TilS substrate C-terminal domain; Region: TilS_C; smart00977 573413006065 FtsH Extracellular; Region: FtsH_ext; pfam06480 573413006066 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573413006067 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 573413006068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413006069 Walker A motif; other site 573413006070 ATP binding site [chemical binding]; other site 573413006071 Walker B motif; other site 573413006072 arginine finger; other site 573413006073 Peptidase family M41; Region: Peptidase_M41; pfam01434 573413006074 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 573413006075 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573413006076 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573413006077 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 573413006078 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573413006079 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413006080 putative binding surface; other site 573413006081 active site 573413006082 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573413006083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413006084 ATP binding site [chemical binding]; other site 573413006085 Mg2+ binding site [ion binding]; other site 573413006086 G-X-G motif; other site 573413006087 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573413006088 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 573413006089 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573413006090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413006091 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573413006092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006093 active site 573413006094 phosphorylation site [posttranslational modification] 573413006095 intermolecular recognition site; other site 573413006096 dimerization interface [polypeptide binding]; other site 573413006097 CheB methylesterase; Region: CheB_methylest; pfam01339 573413006098 Response regulator receiver domain; Region: Response_reg; pfam00072 573413006099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006100 active site 573413006101 phosphorylation site [posttranslational modification] 573413006102 intermolecular recognition site; other site 573413006103 dimerization interface [polypeptide binding]; other site 573413006104 PAS domain S-box; Region: sensory_box; TIGR00229 573413006105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413006106 putative active site [active] 573413006107 heme pocket [chemical binding]; other site 573413006108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413006109 Histidine kinase; Region: HisKA_3; pfam07730 573413006110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413006111 ATP binding site [chemical binding]; other site 573413006112 Mg2+ binding site [ion binding]; other site 573413006113 G-X-G motif; other site 573413006114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413006115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006116 active site 573413006117 phosphorylation site [posttranslational modification] 573413006118 intermolecular recognition site; other site 573413006119 dimerization interface [polypeptide binding]; other site 573413006120 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413006121 DNA binding residues [nucleotide binding] 573413006122 dimerization interface [polypeptide binding]; other site 573413006123 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413006124 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006125 active site 573413006126 phosphorylation site [posttranslational modification] 573413006127 intermolecular recognition site; other site 573413006128 dimerization interface [polypeptide binding]; other site 573413006129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413006130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413006131 dimer interface [polypeptide binding]; other site 573413006132 phosphorylation site [posttranslational modification] 573413006133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413006134 ATP binding site [chemical binding]; other site 573413006135 Mg2+ binding site [ion binding]; other site 573413006136 G-X-G motif; other site 573413006137 Response regulator receiver domain; Region: Response_reg; pfam00072 573413006138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006139 active site 573413006140 phosphorylation site [posttranslational modification] 573413006141 intermolecular recognition site; other site 573413006142 dimerization interface [polypeptide binding]; other site 573413006143 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413006144 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413006145 putative active site [active] 573413006146 heme pocket [chemical binding]; other site 573413006147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413006148 dimer interface [polypeptide binding]; other site 573413006149 phosphorylation site [posttranslational modification] 573413006150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413006151 ATP binding site [chemical binding]; other site 573413006152 Mg2+ binding site [ion binding]; other site 573413006153 G-X-G motif; other site 573413006154 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413006155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006156 active site 573413006157 phosphorylation site [posttranslational modification] 573413006158 intermolecular recognition site; other site 573413006159 dimerization interface [polypeptide binding]; other site 573413006160 GTP-binding protein LepA; Provisional; Region: PRK05433 573413006161 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573413006162 G1 box; other site 573413006163 putative GEF interaction site [polypeptide binding]; other site 573413006164 GTP/Mg2+ binding site [chemical binding]; other site 573413006165 Switch I region; other site 573413006166 G2 box; other site 573413006167 G3 box; other site 573413006168 Switch II region; other site 573413006169 G4 box; other site 573413006170 G5 box; other site 573413006171 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573413006172 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573413006173 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573413006174 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 573413006175 SurA N-terminal domain; Region: SurA_N_3; cl07813 573413006176 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573413006177 DnaJ_C chaperone protein; Provisional; Region: PTZ00037 573413006178 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 573413006179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413006180 dimerization interface [polypeptide binding]; other site 573413006181 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413006182 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413006183 dimer interface [polypeptide binding]; other site 573413006184 putative CheW interface [polypeptide binding]; other site 573413006185 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 573413006186 DNA methylase; Region: N6_N4_Mtase; pfam01555 573413006187 hypothetical protein; Provisional; Region: PRK13560 573413006188 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413006189 PAS domain; Region: PAS_9; pfam13426 573413006190 putative active site [active] 573413006191 heme pocket [chemical binding]; other site 573413006192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413006193 PAS domain; Region: PAS_9; pfam13426 573413006194 putative active site [active] 573413006195 heme pocket [chemical binding]; other site 573413006196 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413006197 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413006198 DNA binding residues [nucleotide binding] 573413006199 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413006200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413006201 DNA-binding site [nucleotide binding]; DNA binding site 573413006202 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413006203 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413006204 dimerization interface [polypeptide binding]; other site 573413006205 ligand binding site [chemical binding]; other site 573413006206 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 573413006207 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413006208 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413006209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006210 dimer interface [polypeptide binding]; other site 573413006211 conserved gate region; other site 573413006212 putative PBP binding loops; other site 573413006213 ABC-ATPase subunit interface; other site 573413006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006215 dimer interface [polypeptide binding]; other site 573413006216 conserved gate region; other site 573413006217 putative PBP binding loops; other site 573413006218 ABC-ATPase subunit interface; other site 573413006219 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 573413006220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413006221 Walker A/P-loop; other site 573413006222 ATP binding site [chemical binding]; other site 573413006223 Q-loop/lid; other site 573413006224 ABC transporter signature motif; other site 573413006225 Walker B; other site 573413006226 D-loop; other site 573413006227 H-loop/switch region; other site 573413006228 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 573413006229 Trehalase; Region: Trehalase; cl17346 573413006230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413006231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413006232 DNA binding site [nucleotide binding] 573413006233 domain linker motif; other site 573413006234 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413006235 dimerization interface [polypeptide binding]; other site 573413006236 ligand binding site [chemical binding]; other site 573413006237 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 573413006238 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413006239 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 573413006240 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413006241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006242 dimer interface [polypeptide binding]; other site 573413006243 conserved gate region; other site 573413006244 putative PBP binding loops; other site 573413006245 ABC-ATPase subunit interface; other site 573413006246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006247 dimer interface [polypeptide binding]; other site 573413006248 conserved gate region; other site 573413006249 putative PBP binding loops; other site 573413006250 ABC-ATPase subunit interface; other site 573413006251 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413006252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413006253 Walker A/P-loop; other site 573413006254 ATP binding site [chemical binding]; other site 573413006255 Q-loop/lid; other site 573413006256 ABC transporter signature motif; other site 573413006257 Walker B; other site 573413006258 D-loop; other site 573413006259 H-loop/switch region; other site 573413006260 TOBE domain; Region: TOBE_2; pfam08402 573413006261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413006262 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573413006263 active site 573413006264 motif I; other site 573413006265 motif II; other site 573413006266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413006267 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413006268 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413006269 substrate binding site [chemical binding]; other site 573413006270 ATP binding site [chemical binding]; other site 573413006271 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413006272 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413006273 DNA binding site [nucleotide binding] 573413006274 domain linker motif; other site 573413006275 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413006276 dimerization interface [polypeptide binding]; other site 573413006277 ligand binding site [chemical binding]; other site 573413006278 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 573413006279 active site 573413006280 PHP-associated; Region: PHP_C; pfam13263 573413006281 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573413006282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413006283 active site 573413006284 motif I; other site 573413006285 motif II; other site 573413006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006287 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413006288 dimer interface [polypeptide binding]; other site 573413006289 conserved gate region; other site 573413006290 putative PBP binding loops; other site 573413006291 ABC-ATPase subunit interface; other site 573413006292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006293 dimer interface [polypeptide binding]; other site 573413006294 conserved gate region; other site 573413006295 putative PBP binding loops; other site 573413006296 ABC-ATPase subunit interface; other site 573413006297 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413006298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413006299 Walker A/P-loop; other site 573413006300 ATP binding site [chemical binding]; other site 573413006301 Q-loop/lid; other site 573413006302 ABC transporter signature motif; other site 573413006303 Walker B; other site 573413006304 D-loop; other site 573413006305 H-loop/switch region; other site 573413006306 TOBE domain; Region: TOBE_2; pfam08402 573413006307 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 573413006308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413006309 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413006310 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413006311 substrate binding site [chemical binding]; other site 573413006312 ATP binding site [chemical binding]; other site 573413006313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413006314 DNA-binding site [nucleotide binding]; DNA binding site 573413006315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413006316 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413006317 ligand binding site [chemical binding]; other site 573413006318 dimerization interface [polypeptide binding]; other site 573413006319 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413006320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413006321 nucleotide binding site [chemical binding]; other site 573413006322 Class I aldolases; Region: Aldolase_Class_I; cl17187 573413006323 catalytic residue [active] 573413006324 hypothetical protein; Provisional; Region: PRK02947 573413006325 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413006326 putative active site [active] 573413006327 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413006328 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 573413006329 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413006330 putative ligand binding site [chemical binding]; other site 573413006331 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573413006332 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413006333 Walker A/P-loop; other site 573413006334 ATP binding site [chemical binding]; other site 573413006335 Q-loop/lid; other site 573413006336 ABC transporter signature motif; other site 573413006337 Walker B; other site 573413006338 D-loop; other site 573413006339 H-loop/switch region; other site 573413006340 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413006341 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413006342 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413006343 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413006344 TM-ABC transporter signature motif; other site 573413006345 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 573413006346 Uncharacterized conserved protein [Function unknown]; Region: COG2006 573413006347 Protein of unknown function (DUF3276); Region: DUF3276; pfam11680 573413006348 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573413006349 RNA/DNA hybrid binding site [nucleotide binding]; other site 573413006350 active site 573413006351 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 573413006352 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573413006353 Walker A/P-loop; other site 573413006354 ATP binding site [chemical binding]; other site 573413006355 Q-loop/lid; other site 573413006356 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 573413006357 ABC transporter signature motif; other site 573413006358 Walker B; other site 573413006359 D-loop; other site 573413006360 H-loop/switch region; other site 573413006361 Sel1 repeat; Region: Sel1; cl02723 573413006362 signal recognition particle protein; Provisional; Region: PRK10867 573413006363 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573413006364 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573413006365 P loop; other site 573413006366 GTP binding site [chemical binding]; other site 573413006367 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573413006368 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 573413006369 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 573413006370 hypothetical protein; Provisional; Region: PRK00468 573413006371 G-X-X-G motif; other site 573413006372 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 573413006373 RimM N-terminal domain; Region: RimM; pfam01782 573413006374 PRC-barrel domain; Region: PRC; pfam05239 573413006375 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573413006376 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573413006377 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 573413006378 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573413006379 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413006380 Zn2+ binding site [ion binding]; other site 573413006381 Mg2+ binding site [ion binding]; other site 573413006382 hypothetical protein; Reviewed; Region: PRK12497 573413006383 Predicted transcriptional regulators [Transcription]; Region: COG1695 573413006384 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573413006385 HEAT-like repeat; Region: HEAT_EZ; pfam13513 573413006386 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573413006387 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573413006388 active site 573413006389 (T/H)XGH motif; other site 573413006390 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 573413006391 acyl carrier protein; Provisional; Region: acpP; PRK00982 573413006392 ribonuclease III; Reviewed; Region: rnc; PRK00102 573413006393 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573413006394 dimerization interface [polypeptide binding]; other site 573413006395 active site 573413006396 metal binding site [ion binding]; metal-binding site 573413006397 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573413006398 dsRNA binding site [nucleotide binding]; other site 573413006399 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573413006400 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 573413006401 active site 573413006402 NTP binding site [chemical binding]; other site 573413006403 metal binding triad [ion binding]; metal-binding site 573413006404 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573413006405 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413006406 Zn2+ binding site [ion binding]; other site 573413006407 Mg2+ binding site [ion binding]; other site 573413006408 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 573413006409 flagellin; Provisional; Region: PRK12804 573413006410 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573413006411 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573413006412 6-phosphofructokinase; Provisional; Region: PRK03202 573413006413 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 573413006414 active site 573413006415 ADP/pyrophosphate binding site [chemical binding]; other site 573413006416 dimerization interface [polypeptide binding]; other site 573413006417 allosteric effector site; other site 573413006418 fructose-1,6-bisphosphate binding site; other site 573413006419 polyphosphate kinase 1; Region: poly_P_kin; TIGR03705 573413006420 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 573413006421 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 573413006422 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 573413006423 domain interface [polypeptide binding]; other site 573413006424 active site 573413006425 catalytic site [active] 573413006426 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 573413006427 putative active site [active] 573413006428 catalytic site [active] 573413006429 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 573413006430 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573413006431 HIGH motif; other site 573413006432 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573413006433 active site 573413006434 KMSKS motif; other site 573413006435 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 573413006436 tRNA binding surface [nucleotide binding]; other site 573413006437 anticodon binding site; other site 573413006438 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 573413006439 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573413006440 putative active site [active] 573413006441 oxyanion strand; other site 573413006442 catalytic triad [active] 573413006443 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573413006444 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573413006445 substrate binding site [chemical binding]; other site 573413006446 glutamase interaction surface [polypeptide binding]; other site 573413006447 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 573413006448 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 573413006449 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 573413006450 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 573413006451 Ligand Binding Site [chemical binding]; other site 573413006452 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413006453 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573413006454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413006455 catalytic residue [active] 573413006456 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413006457 dimerization interface [polypeptide binding]; other site 573413006458 putative DNA binding site [nucleotide binding]; other site 573413006459 putative Zn2+ binding site [ion binding]; other site 573413006460 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573413006461 active site 573413006462 dimer interface [polypeptide binding]; other site 573413006463 metal binding site [ion binding]; metal-binding site 573413006464 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573413006465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413006466 ATP binding site [chemical binding]; other site 573413006467 putative Mg++ binding site [ion binding]; other site 573413006468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413006469 nucleotide binding region [chemical binding]; other site 573413006470 ATP-binding site [chemical binding]; other site 573413006471 Helicase associated domain (HA2); Region: HA2; pfam04408 573413006472 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 573413006473 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 573413006474 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573413006475 dimer interface [polypeptide binding]; other site 573413006476 motif 1; other site 573413006477 active site 573413006478 motif 2; other site 573413006479 motif 3; other site 573413006480 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573413006481 anticodon binding site; other site 573413006482 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573413006483 active site 573413006484 NTP binding site [chemical binding]; other site 573413006485 metal binding triad [ion binding]; metal-binding site 573413006486 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573413006487 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 573413006488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413006489 binding surface 573413006490 TPR motif; other site 573413006491 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 573413006492 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 573413006493 SLBB domain; Region: SLBB; pfam10531 573413006494 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413006495 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 573413006496 FMN-binding domain; Region: FMN_bind; cl01081 573413006497 electron transport complex RsxE subunit; Provisional; Region: PRK12405 573413006498 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 573413006499 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413006500 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 573413006501 4Fe-4S binding domain; Region: Fer4; pfam00037 573413006502 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 573413006503 active site 573413006504 catalytic site [active] 573413006505 homodimer interface [polypeptide binding]; other site 573413006506 Lid 1; other site 573413006507 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 573413006508 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 573413006509 peptide chain release factor 2; Validated; Region: prfB; PRK00578 573413006510 PCRF domain; Region: PCRF; pfam03462 573413006511 RF-1 domain; Region: RF-1; pfam00472 573413006512 Response regulator receiver domain; Region: Response_reg; pfam00072 573413006513 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006514 active site 573413006515 phosphorylation site [posttranslational modification] 573413006516 intermolecular recognition site; other site 573413006517 dimerization interface [polypeptide binding]; other site 573413006518 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 573413006519 PEGA domain; Region: PEGA; pfam08308 573413006520 PEGA domain; Region: PEGA; pfam08308 573413006521 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573413006522 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 573413006523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413006524 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573413006525 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413006526 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413006527 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573413006528 Walker A/P-loop; other site 573413006529 ATP binding site [chemical binding]; other site 573413006530 Q-loop/lid; other site 573413006531 ABC transporter signature motif; other site 573413006532 Walker B; other site 573413006533 D-loop; other site 573413006534 H-loop/switch region; other site 573413006535 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573413006536 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413006537 FtsX-like permease family; Region: FtsX; pfam02687 573413006538 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 573413006539 UvrB/uvrC motif; Region: UVR; pfam02151 573413006540 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 573413006541 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 573413006542 ADP binding site [chemical binding]; other site 573413006543 phosphagen binding site; other site 573413006544 substrate specificity loop; other site 573413006545 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 573413006546 Clp amino terminal domain; Region: Clp_N; pfam02861 573413006547 Clp amino terminal domain; Region: Clp_N; pfam02861 573413006548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413006549 Walker A motif; other site 573413006550 ATP binding site [chemical binding]; other site 573413006551 Walker B motif; other site 573413006552 arginine finger; other site 573413006553 UvrB/uvrC motif; Region: UVR; pfam02151 573413006554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413006555 Walker A motif; other site 573413006556 ATP binding site [chemical binding]; other site 573413006557 Walker B motif; other site 573413006558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573413006559 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573413006560 active site 573413006561 catalytic site [active] 573413006562 substrate binding site [chemical binding]; other site 573413006563 ribonuclease Z; Region: RNase_Z; TIGR02651 573413006564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413006565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413006566 metal binding site [ion binding]; metal-binding site 573413006567 active site 573413006568 I-site; other site 573413006569 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 573413006570 putative ligand binding pocket/active site [active] 573413006571 putative metal binding site [ion binding]; other site 573413006572 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 573413006573 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 573413006574 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 573413006575 Septum formation initiator; Region: DivIC; cl17659 573413006576 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 573413006577 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 573413006578 Thiamine pyrophosphokinase; Region: TPK; cd07995 573413006579 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 573413006580 active site 573413006581 dimerization interface [polypeptide binding]; other site 573413006582 thiamine binding site [chemical binding]; other site 573413006583 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 573413006584 nucleotide binding site/active site [active] 573413006585 HIT family signature motif; other site 573413006586 catalytic residue [active] 573413006587 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573413006588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413006589 motif II; other site 573413006590 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573413006591 active site 573413006592 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 573413006593 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573413006594 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573413006595 S-layer homology domain; Region: SLH; pfam00395 573413006596 S-layer homology domain; Region: SLH; pfam00395 573413006597 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 573413006598 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 573413006599 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573413006600 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 573413006601 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 573413006602 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573413006603 Interdomain contacts; other site 573413006604 Cytokine receptor motif; other site 573413006605 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 573413006606 Helix-turn-helix domain; Region: HTH_18; pfam12833 573413006607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413006608 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 573413006609 putative active site [active] 573413006610 putative acetyltransferase; Provisional; Region: PRK03624 573413006611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413006612 Coenzyme A binding pocket [chemical binding]; other site 573413006613 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 573413006614 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 573413006615 active site 573413006616 substrate binding site [chemical binding]; other site 573413006617 Mg2+ binding site [ion binding]; other site 573413006618 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573413006619 MULE transposase domain; Region: MULE; pfam10551 573413006620 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 573413006621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573413006622 HerA helicase [Replication, recombination, and repair]; Region: COG0433 573413006623 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 573413006624 DNA binding residues [nucleotide binding] 573413006625 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 573413006626 RecT family; Region: RecT; cl04285 573413006627 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413006628 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413006629 dimer interface [polypeptide binding]; other site 573413006630 ssDNA binding site [nucleotide binding]; other site 573413006631 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413006632 Phage terminase, small subunit; Region: Terminase_4; pfam05119 573413006633 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573413006634 Phage-related protein [Function unknown]; Region: COG4695 573413006635 Phage portal protein; Region: Phage_portal; pfam04860 573413006636 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 573413006637 oligomer interface [polypeptide binding]; other site 573413006638 active site residues [active] 573413006639 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573413006640 Phage capsid family; Region: Phage_capsid; pfam05065 573413006641 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 573413006642 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 573413006643 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573413006644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 573413006645 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 573413006646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 573413006647 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573413006648 active site 573413006649 catalytic residues [active] 573413006650 DNA binding site [nucleotide binding] 573413006651 Int/Topo IB signature motif; other site 573413006652 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 573413006653 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573413006654 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573413006655 SmpB-tmRNA interface; other site 573413006656 PEGA domain; Region: PEGA; pfam08308 573413006657 Uncharacterized conserved protein [Function unknown]; Region: COG1262 573413006658 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 573413006659 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 573413006660 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573413006661 Catalytic site [active] 573413006662 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573413006663 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573413006664 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 573413006665 HemN C-terminal domain; Region: HemN_C; pfam06969 573413006666 hypothetical protein; Validated; Region: PRK00110 573413006667 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 573413006668 active site 573413006669 putative DNA-binding cleft [nucleotide binding]; other site 573413006670 dimer interface [polypeptide binding]; other site 573413006671 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 573413006672 RuvA N terminal domain; Region: RuvA_N; pfam01330 573413006673 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573413006674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413006675 Walker A motif; other site 573413006676 ATP binding site [chemical binding]; other site 573413006677 Walker B motif; other site 573413006678 arginine finger; other site 573413006679 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573413006680 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 573413006681 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 573413006682 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573413006683 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 573413006684 TMP-binding site; other site 573413006685 ATP-binding site [chemical binding]; other site 573413006686 Family of unknown function (DUF490); Region: DUF490; pfam04357 573413006687 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 573413006688 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413006689 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413006690 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413006691 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413006692 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 573413006693 Surface antigen; Region: Bac_surface_Ag; pfam01103 573413006694 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 573413006695 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 573413006696 MutS domain I; Region: MutS_I; pfam01624 573413006697 MutS domain II; Region: MutS_II; pfam05188 573413006698 MutS domain III; Region: MutS_III; pfam05192 573413006699 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 573413006700 Walker A/P-loop; other site 573413006701 ATP binding site [chemical binding]; other site 573413006702 Q-loop/lid; other site 573413006703 ABC transporter signature motif; other site 573413006704 Walker B; other site 573413006705 D-loop; other site 573413006706 H-loop/switch region; other site 573413006707 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 573413006708 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413006709 active site 573413006710 hypothetical protein; Provisional; Region: PRK14637 573413006711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779 573413006712 heptamer interface [polypeptide binding]; other site 573413006713 Sm1 motif; other site 573413006714 hexamer interface [polypeptide binding]; other site 573413006715 RNA binding site [nucleotide binding]; other site 573413006716 Sm2 motif; other site 573413006717 transcription termination factor NusA; Region: NusA; TIGR01953 573413006718 NusA N-terminal domain; Region: NusA_N; pfam08529 573413006719 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573413006720 RNA binding site [nucleotide binding]; other site 573413006721 homodimer interface [polypeptide binding]; other site 573413006722 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573413006723 G-X-X-G motif; other site 573413006724 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573413006725 G-X-X-G motif; other site 573413006726 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 573413006727 Double zinc ribbon; Region: DZR; pfam12773 573413006728 translation initiation factor IF-2; Region: IF-2; TIGR00487 573413006729 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573413006730 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573413006731 G1 box; other site 573413006732 putative GEF interaction site [polypeptide binding]; other site 573413006733 GTP/Mg2+ binding site [chemical binding]; other site 573413006734 Switch I region; other site 573413006735 G2 box; other site 573413006736 G3 box; other site 573413006737 Switch II region; other site 573413006738 G4 box; other site 573413006739 G5 box; other site 573413006740 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573413006741 Translation-initiation factor 2; Region: IF-2; pfam11987 573413006742 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573413006743 Ribosome-binding factor A; Region: RBFA; pfam02033 573413006744 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573413006745 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 573413006746 RNA binding site [nucleotide binding]; other site 573413006747 active site 573413006748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413006749 active site 573413006750 nucleotide binding site [chemical binding]; other site 573413006751 HIGH motif; other site 573413006752 KMSKS motif; other site 573413006753 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573413006754 16S/18S rRNA binding site [nucleotide binding]; other site 573413006755 S13e-L30e interaction site [polypeptide binding]; other site 573413006756 25S rRNA binding site [nucleotide binding]; other site 573413006757 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 573413006758 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 573413006759 RNase E interface [polypeptide binding]; other site 573413006760 trimer interface [polypeptide binding]; other site 573413006761 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573413006762 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573413006763 RNase E interface [polypeptide binding]; other site 573413006764 trimer interface [polypeptide binding]; other site 573413006765 active site 573413006766 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573413006767 putative nucleic acid binding region [nucleotide binding]; other site 573413006768 G-X-X-G motif; other site 573413006769 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573413006770 RNA binding site [nucleotide binding]; other site 573413006771 domain interface; other site 573413006772 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573413006773 trimer interface [polypeptide binding]; other site 573413006774 active site 573413006775 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573413006776 Predicted permeases [General function prediction only]; Region: COG0795 573413006777 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 573413006778 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 573413006779 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573413006780 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 573413006781 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 573413006782 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573413006783 HEAT repeats; Region: HEAT_2; pfam13646 573413006784 HEAT repeats; Region: HEAT_2; pfam13646 573413006785 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 573413006786 integrin inhibitor binding pocket; other site 573413006787 metal ion-dependent adhesion site (MIDAS); other site 573413006788 integrin-collagen binding site; other site 573413006789 putative vWF-collagen binding site; other site 573413006790 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 573413006791 transcript cleavage factor/unknown domain fusion protein; Provisional; Region: PRK14720 573413006792 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573413006793 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573413006794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413006795 TPR motif; other site 573413006796 TPR repeat; Region: TPR_11; pfam13414 573413006797 binding surface 573413006798 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 573413006799 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 573413006800 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413006801 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413006802 catalytic loop [active] 573413006803 iron binding site [ion binding]; other site 573413006804 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413006805 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 573413006806 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413006807 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413006808 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 573413006809 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573413006810 substrate binding site [chemical binding]; other site 573413006811 hexamer interface [polypeptide binding]; other site 573413006812 metal binding site [ion binding]; metal-binding site 573413006813 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573413006814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413006815 binding surface 573413006816 TPR motif; other site 573413006817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413006818 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413006819 TPR motif; other site 573413006820 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413006821 binding surface 573413006822 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 573413006823 putative active site [active] 573413006824 dimerization interface [polypeptide binding]; other site 573413006825 putative tRNAtyr binding site [nucleotide binding]; other site 573413006826 recombinase A; Provisional; Region: recA; PRK09354 573413006827 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573413006828 hexamer interface [polypeptide binding]; other site 573413006829 Walker A motif; other site 573413006830 ATP binding site [chemical binding]; other site 573413006831 Walker B motif; other site 573413006832 ScpA/B protein; Region: ScpA_ScpB; cl00598 573413006833 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 573413006834 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573413006835 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573413006836 RNA binding surface [nucleotide binding]; other site 573413006837 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 573413006838 active site 573413006839 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 573413006840 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573413006841 CMP-binding site; other site 573413006842 The sites determining sugar specificity; other site 573413006843 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 573413006844 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573413006845 RNA binding site [nucleotide binding]; other site 573413006846 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573413006847 RNA binding site [nucleotide binding]; other site 573413006848 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573413006849 RNA binding site [nucleotide binding]; other site 573413006850 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573413006851 RNA binding site [nucleotide binding]; other site 573413006852 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573413006853 RNA binding site [nucleotide binding]; other site 573413006854 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 573413006855 RNA binding site [nucleotide binding]; other site 573413006856 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 573413006857 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413006858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413006859 Walker A motif; other site 573413006860 ATP binding site [chemical binding]; other site 573413006861 Walker B motif; other site 573413006862 arginine finger; other site 573413006863 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573413006864 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573413006865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413006866 TPR motif; other site 573413006867 binding surface 573413006868 CHASE2 domain; Region: CHASE2; pfam05226 573413006869 CHASE2 domain; Region: CHASE2; pfam05226 573413006870 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413006871 cyclase homology domain; Region: CHD; cd07302 573413006872 nucleotidyl binding site; other site 573413006873 metal binding site [ion binding]; metal-binding site 573413006874 dimer interface [polypeptide binding]; other site 573413006875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413006876 Response regulator receiver domain; Region: Response_reg; pfam00072 573413006877 active site 573413006878 phosphorylation site [posttranslational modification] 573413006879 intermolecular recognition site; other site 573413006880 dimerization interface [polypeptide binding]; other site 573413006881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413006882 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413006883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413006884 Histidine kinase; Region: His_kinase; pfam06580 573413006885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413006886 ATP binding site [chemical binding]; other site 573413006887 Mg2+ binding site [ion binding]; other site 573413006888 G-X-G motif; other site 573413006889 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413006890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413006891 Walker A/P-loop; other site 573413006892 ATP binding site [chemical binding]; other site 573413006893 Q-loop/lid; other site 573413006894 ABC transporter signature motif; other site 573413006895 Walker B; other site 573413006896 H-loop/switch region; other site 573413006897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413006898 Walker A/P-loop; other site 573413006899 ATP binding site [chemical binding]; other site 573413006900 Q-loop/lid; other site 573413006901 Walker B; other site 573413006902 D-loop; other site 573413006903 H-loop/switch region; other site 573413006904 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413006905 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413006906 TM-ABC transporter signature motif; other site 573413006907 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413006908 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413006909 Walker A/P-loop; other site 573413006910 ATP binding site [chemical binding]; other site 573413006911 Q-loop/lid; other site 573413006912 ABC transporter signature motif; other site 573413006913 Walker B; other site 573413006914 D-loop; other site 573413006915 H-loop/switch region; other site 573413006916 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413006917 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413006918 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413006919 TM-ABC transporter signature motif; other site 573413006920 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413006921 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 573413006922 putative ligand binding site [chemical binding]; other site 573413006923 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 573413006924 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 573413006925 homodimer interface [polypeptide binding]; other site 573413006926 metal binding site [ion binding]; metal-binding site 573413006927 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 573413006928 homodimer interface [polypeptide binding]; other site 573413006929 active site 573413006930 putative chemical substrate binding site [chemical binding]; other site 573413006931 metal binding site [ion binding]; metal-binding site 573413006932 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 573413006933 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573413006934 B12 binding site [chemical binding]; other site 573413006935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413006936 FeS/SAM binding site; other site 573413006937 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 573413006938 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 573413006939 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 573413006940 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 573413006941 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 573413006942 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573413006943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573413006944 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 573413006945 rod shape-determining protein MreC; Provisional; Region: PRK13922 573413006946 rod shape-determining protein MreC; Region: MreC; pfam04085 573413006947 rod shape-determining protein MreB; Provisional; Region: PRK13927 573413006948 MreB and similar proteins; Region: MreB_like; cd10225 573413006949 nucleotide binding site [chemical binding]; other site 573413006950 Mg binding site [ion binding]; other site 573413006951 putative protofilament interaction site [polypeptide binding]; other site 573413006952 RodZ interaction site [polypeptide binding]; other site 573413006953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413006954 TPR motif; other site 573413006955 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413006956 binding surface 573413006957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413006958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413006959 binding surface 573413006960 TPR motif; other site 573413006961 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413006962 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 573413006963 Putative zinc ribbon domain; Region: DUF164; pfam02591 573413006964 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 573413006965 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 573413006966 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573413006967 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413006968 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573413006969 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413006970 DNA binding residues [nucleotide binding] 573413006971 DNA primase, catalytic core; Region: dnaG; TIGR01391 573413006972 CHC2 zinc finger; Region: zf-CHC2; pfam01807 573413006973 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573413006974 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573413006975 active site 573413006976 metal binding site [ion binding]; metal-binding site 573413006977 interdomain interaction site; other site 573413006978 YceG-like family; Region: YceG; pfam02618 573413006979 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 573413006980 dimerization interface [polypeptide binding]; other site 573413006981 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413006982 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413006983 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413006984 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413006985 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413006986 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413006987 ligand binding site [chemical binding]; other site 573413006988 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 573413006989 Flagellin N-methylase; Region: FliB; cl00497 573413006990 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 573413006991 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 573413006992 putative transposase OrfB; Reviewed; Region: PHA02517 573413006993 HTH-like domain; Region: HTH_21; pfam13276 573413006994 Integrase core domain; Region: rve; pfam00665 573413006995 Integrase core domain; Region: rve_3; pfam13683 573413006996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413006997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413006998 dimer interface [polypeptide binding]; other site 573413006999 conserved gate region; other site 573413007000 putative PBP binding loops; other site 573413007001 ABC-ATPase subunit interface; other site 573413007002 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413007003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007004 dimer interface [polypeptide binding]; other site 573413007005 conserved gate region; other site 573413007006 putative PBP binding loops; other site 573413007007 ABC-ATPase subunit interface; other site 573413007008 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413007009 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413007010 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413007011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413007012 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413007013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413007014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413007015 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573413007016 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573413007017 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573413007018 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573413007019 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 573413007020 PEGA domain; Region: PEGA; pfam08308 573413007021 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 573413007022 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413007023 EamA-like transporter family; Region: EamA; pfam00892 573413007024 EamA-like transporter family; Region: EamA; pfam00892 573413007025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413007026 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413007027 dimerization interface [polypeptide binding]; other site 573413007028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413007029 dimer interface [polypeptide binding]; other site 573413007030 phosphorylation site [posttranslational modification] 573413007031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007032 ATP binding site [chemical binding]; other site 573413007033 Mg2+ binding site [ion binding]; other site 573413007034 G-X-G motif; other site 573413007035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413007036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007037 active site 573413007038 phosphorylation site [posttranslational modification] 573413007039 intermolecular recognition site; other site 573413007040 dimerization interface [polypeptide binding]; other site 573413007041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413007042 DNA binding site [nucleotide binding] 573413007043 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573413007044 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 573413007045 nucleotide binding site [chemical binding]; other site 573413007046 NEF interaction site [polypeptide binding]; other site 573413007047 SBD interface [polypeptide binding]; other site 573413007048 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 573413007049 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413007050 HSP70 interaction site [polypeptide binding]; other site 573413007051 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 573413007052 Response regulator receiver domain; Region: Response_reg; pfam00072 573413007053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007054 active site 573413007055 phosphorylation site [posttranslational modification] 573413007056 intermolecular recognition site; other site 573413007057 dimerization interface [polypeptide binding]; other site 573413007058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413007059 Histidine kinase; Region: HisKA_2; pfam07568 573413007060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007061 ATP binding site [chemical binding]; other site 573413007062 Mg2+ binding site [ion binding]; other site 573413007063 G-X-G motif; other site 573413007064 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 573413007065 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413007066 MarR family; Region: MarR; pfam01047 573413007067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413007068 Coenzyme A binding pocket [chemical binding]; other site 573413007069 CAAX protease self-immunity; Region: Abi; pfam02517 573413007070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 573413007071 Protein of unknown function, DUF606; Region: DUF606; pfam04657 573413007072 Rrf2 family protein; Region: rrf2_super; TIGR00738 573413007073 Transcriptional regulator; Region: Rrf2; pfam02082 573413007074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 573413007075 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573413007076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413007077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413007078 dimer interface [polypeptide binding]; other site 573413007079 putative CheW interface [polypeptide binding]; other site 573413007080 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 573413007081 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 573413007082 active site 573413007083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413007084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007085 dimer interface [polypeptide binding]; other site 573413007086 conserved gate region; other site 573413007087 putative PBP binding loops; other site 573413007088 ABC-ATPase subunit interface; other site 573413007089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007090 dimer interface [polypeptide binding]; other site 573413007091 conserved gate region; other site 573413007092 putative PBP binding loops; other site 573413007093 ABC-ATPase subunit interface; other site 573413007094 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413007095 PBP superfamily domain; Region: PBP_like_2; cl17296 573413007096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413007097 MarR family; Region: MarR_2; pfam12802 573413007098 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413007099 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413007100 DNA-J related protein; Region: DNAJ_related; pfam12339 573413007101 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413007102 HSP70 interaction site [polypeptide binding]; other site 573413007103 Uncharacterized conserved protein [Function unknown]; Region: COG2454 573413007104 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413007105 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413007106 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 573413007107 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 573413007108 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413007109 phosphate binding site [ion binding]; other site 573413007110 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573413007111 tetramer interface [polypeptide binding]; other site 573413007112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413007113 catalytic residue [active] 573413007114 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 573413007115 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 573413007116 tetramer interface [polypeptide binding]; other site 573413007117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413007118 catalytic residue [active] 573413007119 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573413007120 lipoyl attachment site [posttranslational modification]; other site 573413007121 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 573413007122 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 573413007123 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 573413007124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413007125 putative DNA binding site [nucleotide binding]; other site 573413007126 putative Zn2+ binding site [ion binding]; other site 573413007127 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 573413007128 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413007129 catalytic residue [active] 573413007130 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413007131 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 573413007132 ligand binding site [chemical binding]; other site 573413007133 NAD binding site [chemical binding]; other site 573413007134 dimerization interface [polypeptide binding]; other site 573413007135 catalytic site [active] 573413007136 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 573413007137 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413007138 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413007139 DHH family; Region: DHH; pfam01368 573413007140 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 573413007141 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 573413007142 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 573413007143 Recombination protein O N terminal; Region: RecO_N; pfam11967 573413007144 DNA repair protein RecO; Region: reco; TIGR00613 573413007145 Recombination protein O C terminal; Region: RecO_C; pfam02565 573413007146 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 573413007147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413007148 Walker A motif; other site 573413007149 ATP binding site [chemical binding]; other site 573413007150 Walker B motif; other site 573413007151 arginine finger; other site 573413007152 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573413007153 putative protease; Provisional; Region: PRK15452 573413007154 Peptidase family U32; Region: Peptidase_U32; pfam01136 573413007155 serine hydroxymethyltransferase; Provisional; Region: PRK13580 573413007156 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 573413007157 dimer interface [polypeptide binding]; other site 573413007158 active site 573413007159 glycine-pyridoxal phosphate binding site [chemical binding]; other site 573413007160 folate binding site [chemical binding]; other site 573413007161 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 573413007162 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573413007163 HIGH motif; other site 573413007164 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573413007165 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 573413007166 active site 573413007167 KMSKS motif; other site 573413007168 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573413007169 tRNA binding surface [nucleotide binding]; other site 573413007170 anticodon binding site; other site 573413007171 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 573413007172 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 573413007173 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413007174 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413007175 ligand binding site [chemical binding]; other site 573413007176 flexible hinge region; other site 573413007177 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413007178 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413007179 ligand binding site [chemical binding]; other site 573413007180 flexible hinge region; other site 573413007181 IPT/TIG domain; Region: TIG; pfam01833 573413007182 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 573413007183 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573413007184 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573413007185 Putative zinc-finger; Region: zf-HC2; pfam13490 573413007186 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 573413007187 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413007188 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413007189 DNA binding residues [nucleotide binding] 573413007190 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536 573413007191 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573413007192 active site 573413007193 HIGH motif; other site 573413007194 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573413007195 KMSKS motif; other site 573413007196 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573413007197 tRNA binding surface [nucleotide binding]; other site 573413007198 anticodon binding site; other site 573413007199 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 573413007200 FAD binding domain; Region: FAD_binding_4; pfam01565 573413007201 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573413007202 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 573413007203 MgtE intracellular N domain; Region: MgtE_N; pfam03448 573413007204 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 573413007205 Divalent cation transporter; Region: MgtE; pfam01769 573413007206 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 573413007207 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 573413007208 propionate/acetate kinase; Provisional; Region: PRK12379 573413007209 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 573413007210 active site 573413007211 catalytic residues [active] 573413007212 DNA binding site [nucleotide binding] 573413007213 Int/Topo IB signature motif; other site 573413007214 Protein of unknown function DUF262; Region: DUF262; pfam03235 573413007215 Abortive infection C-terminus; Region: Abi_C; pfam14355 573413007216 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573413007217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413007218 non-specific DNA binding site [nucleotide binding]; other site 573413007219 salt bridge; other site 573413007220 sequence-specific DNA binding site [nucleotide binding]; other site 573413007221 Helix-turn-helix domain; Region: HTH_17; pfam12728 573413007222 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 573413007223 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 573413007224 AAA domain; Region: AAA_24; pfam13479 573413007225 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573413007226 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413007227 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413007228 dimer interface [polypeptide binding]; other site 573413007229 ssDNA binding site [nucleotide binding]; other site 573413007230 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413007231 Phage terminase, small subunit; Region: Terminase_4; pfam05119 573413007232 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573413007233 DinB superfamily; Region: DinB_2; pfam12867 573413007234 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 573413007235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413007236 non-specific DNA binding site [nucleotide binding]; other site 573413007237 salt bridge; other site 573413007238 sequence-specific DNA binding site [nucleotide binding]; other site 573413007239 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 573413007240 Protein of unknown function (DUF497); Region: DUF497; pfam04365 573413007241 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 573413007242 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 573413007243 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 573413007244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 573413007245 Transposase; Region: HTH_Tnp_1; cl17663 573413007246 beta-lactamase TEM; Provisional; Region: PRK15442 573413007247 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 573413007248 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573413007249 MULE transposase domain; Region: MULE; pfam10551 573413007250 TIGR04076 family protein; Region: TIGR04076 573413007251 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 573413007252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413007253 active site 573413007254 nucleotide binding site [chemical binding]; other site 573413007255 HIGH motif; other site 573413007256 KMSKS motif; other site 573413007257 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 573413007258 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 573413007259 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 573413007260 Coenzyme A transferase; Region: CoA_trans; cl17247 573413007261 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 573413007262 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 573413007263 citrate lyase subunit gamma; Provisional; Region: PRK13253 573413007264 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573413007265 Putative esterase; Region: Esterase; pfam00756 573413007266 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413007267 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413007268 DNA binding site [nucleotide binding] 573413007269 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413007270 dimerization interface [polypeptide binding]; other site 573413007271 ligand binding site [chemical binding]; other site 573413007272 Predicted acyl esterases [General function prediction only]; Region: COG2936 573413007273 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 573413007274 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 573413007275 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413007276 Walker A/P-loop; other site 573413007277 ATP binding site [chemical binding]; other site 573413007278 Q-loop/lid; other site 573413007279 ABC transporter signature motif; other site 573413007280 Walker B; other site 573413007281 D-loop; other site 573413007282 H-loop/switch region; other site 573413007283 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573413007284 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413007285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413007286 Walker A/P-loop; other site 573413007287 ATP binding site [chemical binding]; other site 573413007288 Q-loop/lid; other site 573413007289 ABC transporter signature motif; other site 573413007290 Walker B; other site 573413007291 D-loop; other site 573413007292 H-loop/switch region; other site 573413007293 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413007294 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 573413007295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007296 dimer interface [polypeptide binding]; other site 573413007297 conserved gate region; other site 573413007298 putative PBP binding loops; other site 573413007299 ABC-ATPase subunit interface; other site 573413007300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413007301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007302 dimer interface [polypeptide binding]; other site 573413007303 conserved gate region; other site 573413007304 putative PBP binding loops; other site 573413007305 ABC-ATPase subunit interface; other site 573413007306 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413007307 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 573413007308 Putative esterase; Region: Esterase; pfam00756 573413007309 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573413007310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413007311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413007312 DNA binding site [nucleotide binding] 573413007313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413007314 dimerization interface [polypeptide binding]; other site 573413007315 ligand binding site [chemical binding]; other site 573413007316 NAD-dependent deacetylase; Provisional; Region: PRK00481 573413007317 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 573413007318 NAD+ binding site [chemical binding]; other site 573413007319 substrate binding site [chemical binding]; other site 573413007320 Zn binding site [ion binding]; other site 573413007321 HAMP domain; Region: HAMP; pfam00672 573413007322 dimerization interface [polypeptide binding]; other site 573413007323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413007324 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413007325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413007326 dimer interface [polypeptide binding]; other site 573413007327 putative CheW interface [polypeptide binding]; other site 573413007328 PAS domain; Region: PAS_9; pfam13426 573413007329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413007330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413007331 DNA binding residues [nucleotide binding] 573413007332 dimerization interface [polypeptide binding]; other site 573413007333 PAS domain; Region: PAS_9; pfam13426 573413007334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413007335 dimer interface [polypeptide binding]; other site 573413007336 phosphorylation site [posttranslational modification] 573413007337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007338 ATP binding site [chemical binding]; other site 573413007339 Mg2+ binding site [ion binding]; other site 573413007340 G-X-G motif; other site 573413007341 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413007342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007343 active site 573413007344 phosphorylation site [posttranslational modification] 573413007345 intermolecular recognition site; other site 573413007346 dimerization interface [polypeptide binding]; other site 573413007347 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413007348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413007349 putative active site [active] 573413007350 heme pocket [chemical binding]; other site 573413007351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413007352 dimer interface [polypeptide binding]; other site 573413007353 phosphorylation site [posttranslational modification] 573413007354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007355 ATP binding site [chemical binding]; other site 573413007356 Mg2+ binding site [ion binding]; other site 573413007357 G-X-G motif; other site 573413007358 Response regulator receiver domain; Region: Response_reg; pfam00072 573413007359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007360 active site 573413007361 phosphorylation site [posttranslational modification] 573413007362 intermolecular recognition site; other site 573413007363 dimerization interface [polypeptide binding]; other site 573413007364 Response regulator receiver domain; Region: Response_reg; pfam00072 573413007365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007366 active site 573413007367 phosphorylation site [posttranslational modification] 573413007368 intermolecular recognition site; other site 573413007369 dimerization interface [polypeptide binding]; other site 573413007370 TIGR04076 family protein; Region: TIGR04076 573413007371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413007372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413007373 active site 573413007374 catalytic tetrad [active] 573413007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413007376 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573413007377 putative active site [active] 573413007378 heme pocket [chemical binding]; other site 573413007379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413007380 putative active site [active] 573413007381 heme pocket [chemical binding]; other site 573413007382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413007383 dimer interface [polypeptide binding]; other site 573413007384 phosphorylation site [posttranslational modification] 573413007385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007386 ATP binding site [chemical binding]; other site 573413007387 Mg2+ binding site [ion binding]; other site 573413007388 G-X-G motif; other site 573413007389 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413007390 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413007391 DNA binding site [nucleotide binding] 573413007392 domain linker motif; other site 573413007393 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413007394 dimerization interface [polypeptide binding]; other site 573413007395 ligand binding site [chemical binding]; other site 573413007396 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573413007397 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573413007398 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573413007399 heterotetramer interface [polypeptide binding]; other site 573413007400 active site pocket [active] 573413007401 cleavage site 573413007402 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 573413007403 feedback inhibition sensing region; other site 573413007404 homohexameric interface [polypeptide binding]; other site 573413007405 nucleotide binding site [chemical binding]; other site 573413007406 N-acetyl-L-glutamate binding site [chemical binding]; other site 573413007407 acetylornithine aminotransferase; Provisional; Region: PRK02627 573413007408 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573413007409 inhibitor-cofactor binding pocket; inhibition site 573413007410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413007411 catalytic residue [active] 573413007412 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 573413007413 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 573413007414 ATP-binding site [chemical binding]; other site 573413007415 Sugar specificity; other site 573413007416 Pyrimidine base specificity; other site 573413007417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413007418 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413007419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413007420 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413007421 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 573413007422 DJ-1 family protein; Region: not_thiJ; TIGR01383 573413007423 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 573413007424 conserved cys residue [active] 573413007425 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 573413007426 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573413007427 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573413007428 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413007429 acyl-activating enzyme (AAE) consensus motif; other site 573413007430 putative AMP binding site [chemical binding]; other site 573413007431 putative active site [active] 573413007432 putative CoA binding site [chemical binding]; other site 573413007433 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 573413007434 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573413007435 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 573413007436 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 573413007437 putative dimer interface [polypeptide binding]; other site 573413007438 putative anticodon binding site; other site 573413007439 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 573413007440 homodimer interface [polypeptide binding]; other site 573413007441 motif 1; other site 573413007442 motif 2; other site 573413007443 active site 573413007444 motif 3; other site 573413007445 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 573413007446 DctM-like transporters; Region: DctM; pfam06808 573413007447 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 573413007448 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413007449 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573413007450 Predicted integral membrane protein [Function unknown]; Region: COG5660 573413007451 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 573413007452 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 573413007453 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573413007454 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573413007455 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 573413007456 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573413007457 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 573413007458 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 573413007459 active site 573413007460 ADP/pyrophosphate binding site [chemical binding]; other site 573413007461 dimerization interface [polypeptide binding]; other site 573413007462 allosteric effector site; other site 573413007463 fructose-1,6-bisphosphate binding site; other site 573413007464 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413007465 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413007466 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413007467 putative active site [active] 573413007468 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 573413007469 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573413007470 dimer interface [polypeptide binding]; other site 573413007471 active site 573413007472 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413007473 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413007474 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413007475 nucleotide binding site [chemical binding]; other site 573413007476 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413007477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007478 dimer interface [polypeptide binding]; other site 573413007479 conserved gate region; other site 573413007480 ABC-ATPase subunit interface; other site 573413007481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007482 dimer interface [polypeptide binding]; other site 573413007483 conserved gate region; other site 573413007484 putative PBP binding loops; other site 573413007485 ABC-ATPase subunit interface; other site 573413007486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413007487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413007488 Cache domain; Region: Cache_1; pfam02743 573413007489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413007490 dimerization interface [polypeptide binding]; other site 573413007491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413007492 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413007493 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413007494 dimer interface [polypeptide binding]; other site 573413007495 putative CheW interface [polypeptide binding]; other site 573413007496 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413007497 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413007498 active site 573413007499 NAD binding site [chemical binding]; other site 573413007500 metal binding site [ion binding]; metal-binding site 573413007501 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 573413007502 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573413007503 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413007504 acyl-activating enzyme (AAE) consensus motif; other site 573413007505 putative active site [active] 573413007506 putative AMP binding site [chemical binding]; other site 573413007507 putative CoA binding site [chemical binding]; other site 573413007508 FtsH Extracellular; Region: FtsH_ext; pfam06480 573413007509 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573413007510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413007511 Walker A motif; other site 573413007512 ATP binding site [chemical binding]; other site 573413007513 Walker B motif; other site 573413007514 arginine finger; other site 573413007515 Peptidase family M41; Region: Peptidase_M41; pfam01434 573413007516 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 573413007517 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 573413007518 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573413007519 histidinol dehydrogenase; Region: hisD; TIGR00069 573413007520 NAD binding site [chemical binding]; other site 573413007521 dimerization interface [polypeptide binding]; other site 573413007522 product binding site; other site 573413007523 substrate binding site [chemical binding]; other site 573413007524 zinc binding site [ion binding]; other site 573413007525 catalytic residues [active] 573413007526 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 573413007527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573413007528 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 573413007529 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413007530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413007531 homodimer interface [polypeptide binding]; other site 573413007532 catalytic residue [active] 573413007533 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 573413007534 putative ADP-ribose binding site [chemical binding]; other site 573413007535 putative active site [active] 573413007536 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 573413007537 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 573413007538 Domain of unknown function (DUF814); Region: DUF814; pfam05670 573413007539 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 573413007540 AMMECR1; Region: AMMECR1; pfam01871 573413007541 FecR protein; Region: FecR; pfam04773 573413007542 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573413007543 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573413007544 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573413007545 cytidylate kinase; Provisional; Region: PRK04182 573413007546 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573413007547 CMP-binding site; other site 573413007548 The sites determining sugar specificity; other site 573413007549 hypothetical protein; Provisional; Region: PRK11820 573413007550 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 573413007551 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 573413007552 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573413007553 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573413007554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573413007555 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573413007556 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 573413007557 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 573413007558 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 573413007559 putative active site [active] 573413007560 putative metal binding site [ion binding]; other site 573413007561 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573413007562 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 573413007563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 573413007564 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 573413007565 dimer interface [polypeptide binding]; other site 573413007566 pyridoxal binding site [chemical binding]; other site 573413007567 ATP binding site [chemical binding]; other site 573413007568 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 573413007569 active site 573413007570 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 573413007571 substrate binding site [chemical binding]; other site 573413007572 metal binding site [ion binding]; metal-binding site 573413007573 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573413007574 endonuclease III; Region: ENDO3c; smart00478 573413007575 minor groove reading motif; other site 573413007576 helix-hairpin-helix signature motif; other site 573413007577 substrate binding pocket [chemical binding]; other site 573413007578 active site 573413007579 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 573413007580 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573413007581 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573413007582 putative CheA interaction surface; other site 573413007583 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 573413007584 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 573413007585 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573413007586 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 573413007587 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573413007588 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 573413007589 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573413007590 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 573413007591 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573413007592 carboxyltransferase (CT) interaction site; other site 573413007593 biotinylation site [posttranslational modification]; other site 573413007594 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 573413007595 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 573413007596 dimer interface [polypeptide binding]; other site 573413007597 active site 573413007598 CoA binding pocket [chemical binding]; other site 573413007599 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573413007600 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 573413007601 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573413007602 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 573413007603 NAD(P) binding site [chemical binding]; other site 573413007604 homotetramer interface [polypeptide binding]; other site 573413007605 homodimer interface [polypeptide binding]; other site 573413007606 active site 573413007607 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 573413007608 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 573413007609 dimer interface [polypeptide binding]; other site 573413007610 active site 573413007611 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 573413007612 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 573413007613 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 573413007614 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 573413007615 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 573413007616 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 573413007617 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413007618 non-specific DNA binding site [nucleotide binding]; other site 573413007619 salt bridge; other site 573413007620 sequence-specific DNA binding site [nucleotide binding]; other site 573413007621 Cupin domain; Region: Cupin_2; cl17218 573413007622 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 573413007623 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 573413007624 cyclase homology domain; Region: CHD; cd07302 573413007625 nucleotidyl binding site; other site 573413007626 metal binding site [ion binding]; metal-binding site 573413007627 dimer interface [polypeptide binding]; other site 573413007628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 573413007629 Bacterial SH3 domain; Region: SH3_3; pfam08239 573413007630 chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029 573413007631 TrkA-C domain; Region: TrkA_C; pfam02080 573413007632 NMT1/THI5 like; Region: NMT1; pfam09084 573413007633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413007634 substrate binding pocket [chemical binding]; other site 573413007635 membrane-bound complex binding site; other site 573413007636 hinge residues; other site 573413007637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007638 ATP binding site [chemical binding]; other site 573413007639 Mg2+ binding site [ion binding]; other site 573413007640 G-X-G motif; other site 573413007641 Caspase domain; Region: Peptidase_C14; pfam00656 573413007642 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573413007643 asparagine synthetase B; Provisional; Region: asnB; PRK09431 573413007644 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 573413007645 active site 573413007646 dimer interface [polypeptide binding]; other site 573413007647 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 573413007648 Ligand Binding Site [chemical binding]; other site 573413007649 Molecular Tunnel; other site 573413007650 PAS fold; Region: PAS_4; pfam08448 573413007651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413007652 putative active site [active] 573413007653 heme pocket [chemical binding]; other site 573413007654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413007655 Histidine kinase; Region: HisKA_2; pfam07568 573413007656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007657 ATP binding site [chemical binding]; other site 573413007658 Mg2+ binding site [ion binding]; other site 573413007659 G-X-G motif; other site 573413007660 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 573413007661 Response regulator receiver domain; Region: Response_reg; pfam00072 573413007662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413007663 active site 573413007664 phosphorylation site [posttranslational modification] 573413007665 intermolecular recognition site; other site 573413007666 dimerization interface [polypeptide binding]; other site 573413007667 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 573413007668 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 573413007669 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 573413007670 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413007671 acyl-activating enzyme (AAE) consensus motif; other site 573413007672 putative AMP binding site [chemical binding]; other site 573413007673 putative active site [active] 573413007674 putative CoA binding site [chemical binding]; other site 573413007675 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 573413007676 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573413007677 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 573413007678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413007679 Walker A/P-loop; other site 573413007680 ATP binding site [chemical binding]; other site 573413007681 Q-loop/lid; other site 573413007682 ABC transporter signature motif; other site 573413007683 Walker B; other site 573413007684 D-loop; other site 573413007685 H-loop/switch region; other site 573413007686 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 573413007687 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413007688 TM-ABC transporter signature motif; other site 573413007689 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413007690 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 573413007691 zinc binding site [ion binding]; other site 573413007692 putative ligand binding site [chemical binding]; other site 573413007693 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 573413007694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413007695 motif II; other site 573413007696 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 573413007697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413007698 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 573413007699 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 573413007700 active site 573413007701 dimer interface [polypeptide binding]; other site 573413007702 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 573413007703 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573413007704 active site 573413007705 FMN binding site [chemical binding]; other site 573413007706 substrate binding site [chemical binding]; other site 573413007707 3Fe-4S cluster binding site [ion binding]; other site 573413007708 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 573413007709 domain interface; other site 573413007710 helicase 45; Provisional; Region: PTZ00424 573413007711 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573413007712 ATP binding site [chemical binding]; other site 573413007713 Mg++ binding site [ion binding]; other site 573413007714 motif III; other site 573413007715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413007716 nucleotide binding region [chemical binding]; other site 573413007717 ATP-binding site [chemical binding]; other site 573413007718 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 573413007719 RNA binding site [nucleotide binding]; other site 573413007720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413007721 Coenzyme A binding pocket [chemical binding]; other site 573413007722 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573413007723 excinuclease ABC subunit B; Provisional; Region: PRK05298 573413007724 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413007725 ATP binding site [chemical binding]; other site 573413007726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413007727 nucleotide binding region [chemical binding]; other site 573413007728 ATP-binding site [chemical binding]; other site 573413007729 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573413007730 UvrB/uvrC motif; Region: UVR; pfam02151 573413007731 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573413007732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573413007733 protein binding site [polypeptide binding]; other site 573413007734 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 573413007735 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573413007736 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 573413007737 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573413007738 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573413007739 RNA/DNA hybrid binding site [nucleotide binding]; other site 573413007740 active site 573413007741 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 573413007742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413007743 Walker A motif; other site 573413007744 ATP binding site [chemical binding]; other site 573413007745 Walker B motif; other site 573413007746 arginine finger; other site 573413007747 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 573413007748 active site 573413007749 catalytic residues [active] 573413007750 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 573413007751 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 573413007752 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573413007753 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573413007754 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413007755 Walker A/P-loop; other site 573413007756 ATP binding site [chemical binding]; other site 573413007757 Q-loop/lid; other site 573413007758 ABC transporter signature motif; other site 573413007759 Walker B; other site 573413007760 D-loop; other site 573413007761 H-loop/switch region; other site 573413007762 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 573413007763 putative active site [active] 573413007764 putative metal binding residues [ion binding]; other site 573413007765 signature motif; other site 573413007766 putative triphosphate binding site [ion binding]; other site 573413007767 dimer interface [polypeptide binding]; other site 573413007768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413007769 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413007770 putative substrate translocation pore; other site 573413007771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413007772 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573413007773 active site 573413007774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007775 ATP binding site [chemical binding]; other site 573413007776 Mg2+ binding site [ion binding]; other site 573413007777 G-X-G motif; other site 573413007778 PilZ domain; Region: PilZ; pfam07238 573413007779 PilZ domain; Region: PilZ; pfam07238 573413007780 aconitate hydratase; Validated; Region: PRK07229 573413007781 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 573413007782 substrate binding site [chemical binding]; other site 573413007783 ligand binding site [chemical binding]; other site 573413007784 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 573413007785 substrate binding site [chemical binding]; other site 573413007786 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 573413007787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413007788 Zn2+ binding site [ion binding]; other site 573413007789 Mg2+ binding site [ion binding]; other site 573413007790 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 573413007791 Ligand Binding Site [chemical binding]; other site 573413007792 Late competence development protein ComFB; Region: ComFB; pfam10719 573413007793 Protein of unknown function (DUF503); Region: DUF503; pfam04456 573413007794 FecR protein; Region: FecR; pfam04773 573413007795 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 573413007796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007797 ATP binding site [chemical binding]; other site 573413007798 Mg2+ binding site [ion binding]; other site 573413007799 G-X-G motif; other site 573413007800 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 573413007801 ATP binding site [chemical binding]; other site 573413007802 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 573413007803 TPR repeat; Region: TPR_11; pfam13414 573413007804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007805 binding surface 573413007806 TPR motif; other site 573413007807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007808 TPR repeat; Region: TPR_11; pfam13414 573413007809 binding surface 573413007810 TPR motif; other site 573413007811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007812 binding surface 573413007813 TPR repeat; Region: TPR_11; pfam13414 573413007814 TPR motif; other site 573413007815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007816 binding surface 573413007817 TPR motif; other site 573413007818 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413007819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007820 binding surface 573413007821 TPR motif; other site 573413007822 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413007823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007824 binding surface 573413007825 TPR motif; other site 573413007826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413007827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007828 binding surface 573413007829 TPR motif; other site 573413007830 TPR repeat; Region: TPR_11; pfam13414 573413007831 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007832 binding surface 573413007833 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413007834 TPR motif; other site 573413007835 TPR repeat; Region: TPR_11; pfam13414 573413007836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007837 binding surface 573413007838 TPR motif; other site 573413007839 TPR repeat; Region: TPR_11; pfam13414 573413007840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413007841 binding surface 573413007842 TPR motif; other site 573413007843 TPR repeat; Region: TPR_11; pfam13414 573413007844 Restriction endonuclease; Region: Mrr_cat; pfam04471 573413007845 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413007846 active site 573413007847 metal binding site [ion binding]; metal-binding site 573413007848 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 573413007849 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 573413007850 putative acyl-acceptor binding pocket; other site 573413007851 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 573413007852 ribonuclease PH; Reviewed; Region: rph; PRK00173 573413007853 oligomer interface [polypeptide binding]; other site 573413007854 RNA binding site [nucleotide binding]; other site 573413007855 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573413007856 Peptidase family U32; Region: Peptidase_U32; pfam01136 573413007857 Collagenase; Region: DUF3656; pfam12392 573413007858 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413007859 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413007860 ligand binding site [chemical binding]; other site 573413007861 flexible hinge region; other site 573413007862 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413007863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413007864 dimer interface [polypeptide binding]; other site 573413007865 phosphorylation site [posttranslational modification] 573413007866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413007867 ATP binding site [chemical binding]; other site 573413007868 Mg2+ binding site [ion binding]; other site 573413007869 G-X-G motif; other site 573413007870 Uncharacterized conserved protein [Function unknown]; Region: COG0432 573413007871 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 573413007872 ZIP Zinc transporter; Region: Zip; pfam02535 573413007873 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 573413007874 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 573413007875 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573413007876 purine monophosphate binding site [chemical binding]; other site 573413007877 dimer interface [polypeptide binding]; other site 573413007878 putative catalytic residues [active] 573413007879 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 573413007880 Adenylsuccinate lyase (ASL)_like; Region: Adenylsuccinate_lyase_like; cd01595 573413007881 tetramer interface [polypeptide binding]; other site 573413007882 active site 573413007883 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 573413007884 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 573413007885 active site 573413007886 substrate binding site [chemical binding]; other site 573413007887 metal binding site [ion binding]; metal-binding site 573413007888 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573413007889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 573413007890 motif I; other site 573413007891 active site 573413007892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413007893 motif II; other site 573413007894 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 573413007895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413007896 S-adenosylmethionine binding site [chemical binding]; other site 573413007897 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 573413007898 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573413007899 Part of AAA domain; Region: AAA_19; pfam13245 573413007900 Family description; Region: UvrD_C_2; pfam13538 573413007901 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573413007902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413007903 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413007904 EamA-like transporter family; Region: EamA; pfam00892 573413007905 EamA-like transporter family; Region: EamA; pfam00892 573413007906 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573413007907 active site 573413007908 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413007909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413007910 putative DNA binding site [nucleotide binding]; other site 573413007911 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573413007912 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 573413007913 intersubunit interface [polypeptide binding]; other site 573413007914 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 573413007915 active site 573413007916 Zn2+ binding site [ion binding]; other site 573413007917 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413007918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413007919 nucleotide binding site [chemical binding]; other site 573413007920 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413007921 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 573413007922 putative ligand binding site [chemical binding]; other site 573413007923 putative NAD binding site [chemical binding]; other site 573413007924 catalytic site [active] 573413007925 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 573413007926 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 573413007927 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 573413007928 Phosphotransferase enzyme family; Region: APH; pfam01636 573413007929 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 573413007930 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413007931 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413007932 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413007933 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 573413007934 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 573413007935 dimer interface [polypeptide binding]; other site 573413007936 active site 573413007937 metal binding site [ion binding]; metal-binding site 573413007938 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 573413007939 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573413007940 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 573413007941 active site 573413007942 trimer interface [polypeptide binding]; other site 573413007943 allosteric site; other site 573413007944 active site lid [active] 573413007945 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573413007946 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413007947 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413007948 nucleotide binding site [chemical binding]; other site 573413007949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413007950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413007951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413007952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007953 dimer interface [polypeptide binding]; other site 573413007954 conserved gate region; other site 573413007955 putative PBP binding loops; other site 573413007956 ABC-ATPase subunit interface; other site 573413007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007958 dimer interface [polypeptide binding]; other site 573413007959 conserved gate region; other site 573413007960 putative PBP binding loops; other site 573413007961 ABC-ATPase subunit interface; other site 573413007962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413007963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413007964 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413007965 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413007966 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573413007967 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573413007968 Methyltransferase domain; Region: Methyltransf_11; pfam08241 573413007969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007970 dimer interface [polypeptide binding]; other site 573413007971 conserved gate region; other site 573413007972 putative PBP binding loops; other site 573413007973 ABC-ATPase subunit interface; other site 573413007974 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413007975 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413007976 Walker A/P-loop; other site 573413007977 ATP binding site [chemical binding]; other site 573413007978 Q-loop/lid; other site 573413007979 ABC transporter signature motif; other site 573413007980 Walker B; other site 573413007981 D-loop; other site 573413007982 H-loop/switch region; other site 573413007983 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413007984 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413007985 substrate binding pocket [chemical binding]; other site 573413007986 membrane-bound complex binding site; other site 573413007987 hinge residues; other site 573413007988 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573413007989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413007990 dimer interface [polypeptide binding]; other site 573413007991 conserved gate region; other site 573413007992 putative PBP binding loops; other site 573413007993 ABC-ATPase subunit interface; other site 573413007994 GMP synthase; Reviewed; Region: guaA; PRK00074 573413007995 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573413007996 AMP/PPi binding site [chemical binding]; other site 573413007997 candidate oxyanion hole; other site 573413007998 catalytic triad [active] 573413007999 potential glutamine specificity residues [chemical binding]; other site 573413008000 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573413008001 ATP Binding subdomain [chemical binding]; other site 573413008002 Dimerization subdomain; other site 573413008003 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573413008004 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573413008005 GDP-binding site [chemical binding]; other site 573413008006 ACT binding site; other site 573413008007 IMP binding site; other site 573413008008 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413008009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008010 binding surface 573413008011 TPR motif; other site 573413008012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008013 TPR motif; other site 573413008014 binding surface 573413008015 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413008016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008017 TPR motif; other site 573413008018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413008019 binding surface 573413008020 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413008021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008022 binding surface 573413008023 TPR motif; other site 573413008024 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413008025 pyruvate phosphate dikinase; Provisional; Region: PRK09279 573413008026 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573413008027 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413008028 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413008029 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573413008030 metal ion-dependent adhesion site (MIDAS); other site 573413008031 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 573413008032 DHH family; Region: DHH; pfam01368 573413008033 DHHA1 domain; Region: DHHA1; pfam02272 573413008034 Sporulation related domain; Region: SPOR; pfam05036 573413008035 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14335 573413008036 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573413008037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413008038 FeS/SAM binding site; other site 573413008039 TRAM domain; Region: TRAM; pfam01938 573413008040 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 573413008041 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573413008042 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 573413008043 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573413008044 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573413008045 homodimer interface [polypeptide binding]; other site 573413008046 NADP binding site [chemical binding]; other site 573413008047 substrate binding site [chemical binding]; other site 573413008048 Response regulator receiver domain; Region: Response_reg; pfam00072 573413008049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413008050 active site 573413008051 phosphorylation site [posttranslational modification] 573413008052 intermolecular recognition site; other site 573413008053 dimerization interface [polypeptide binding]; other site 573413008054 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 573413008055 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 573413008056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413008057 dimer interface [polypeptide binding]; other site 573413008058 phosphorylation site [posttranslational modification] 573413008059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008060 ATP binding site [chemical binding]; other site 573413008061 Mg2+ binding site [ion binding]; other site 573413008062 G-X-G motif; other site 573413008063 Fn3 associated; Region: Fn3_assoc; pfam13287 573413008064 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 573413008065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413008066 active site 573413008067 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 573413008068 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573413008069 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573413008070 protein binding site [polypeptide binding]; other site 573413008071 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573413008072 protein binding site [polypeptide binding]; other site 573413008073 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573413008074 active site 573413008075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008076 binding surface 573413008077 TPR motif; other site 573413008078 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 573413008079 putative RNA binding site [nucleotide binding]; other site 573413008080 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 573413008081 SurA N-terminal domain; Region: SurA_N_3; cl07813 573413008082 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 573413008083 Preprotein translocase SecG subunit; Region: SecG; pfam03840 573413008084 triosephosphate isomerase; Provisional; Region: PRK14567 573413008085 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573413008086 substrate binding site [chemical binding]; other site 573413008087 dimer interface [polypeptide binding]; other site 573413008088 catalytic triad [active] 573413008089 Phosphoglycerate kinase; Region: PGK; pfam00162 573413008090 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 573413008091 substrate binding site [chemical binding]; other site 573413008092 hinge regions; other site 573413008093 ADP binding site [chemical binding]; other site 573413008094 catalytic site [active] 573413008095 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 573413008096 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 573413008097 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573413008098 TPR repeat; Region: TPR_11; pfam13414 573413008099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008100 binding surface 573413008101 TPR motif; other site 573413008102 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413008103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008104 TPR motif; other site 573413008105 binding surface 573413008106 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573413008107 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573413008108 Transporter associated domain; Region: CorC_HlyC; smart01091 573413008109 metal-binding heat shock protein; Provisional; Region: PRK00016 573413008110 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 573413008111 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 573413008112 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413008113 Zn2+ binding site [ion binding]; other site 573413008114 Mg2+ binding site [ion binding]; other site 573413008115 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573413008116 PhoH-like protein; Region: PhoH; pfam02562 573413008117 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 573413008118 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573413008119 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573413008120 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573413008121 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573413008122 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 573413008123 GcpE protein; Region: GcpE; pfam04551 573413008124 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573413008125 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573413008126 V-type ATP synthase subunit K; Validated; Region: PRK06649 573413008127 V-type ATP synthase subunit I; Validated; Region: PRK05771 573413008128 V-type ATP synthase subunit D; Provisional; Region: PRK02195 573413008129 V-type ATP synthase subunit B; Provisional; Region: PRK02118 573413008130 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573413008131 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 573413008132 Walker A motif homologous position; other site 573413008133 Walker B motif; other site 573413008134 V-type ATP synthase subunit A; Provisional; Region: PRK04192 573413008135 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573413008136 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 573413008137 Walker A motif/ATP binding site; other site 573413008138 Walker B motif; other site 573413008139 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573413008140 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 573413008141 V-type ATP synthase subunit E; Provisional; Region: PRK01558 573413008142 V-type ATP synthase subunit E; Provisional; Region: PRK01005 573413008143 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 573413008144 MutS domain III; Region: MutS_III; pfam05192 573413008145 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 573413008146 Walker A/P-loop; other site 573413008147 ATP binding site [chemical binding]; other site 573413008148 Q-loop/lid; other site 573413008149 ABC transporter signature motif; other site 573413008150 Walker B; other site 573413008151 D-loop; other site 573413008152 H-loop/switch region; other site 573413008153 Smr domain; Region: Smr; pfam01713 573413008154 Predicted GTPases [General function prediction only]; Region: COG1162 573413008155 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573413008156 RNA binding site [nucleotide binding]; other site 573413008157 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573413008158 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573413008159 GTP/Mg2+ binding site [chemical binding]; other site 573413008160 G4 box; other site 573413008161 G5 box; other site 573413008162 G1 box; other site 573413008163 Switch I region; other site 573413008164 G2 box; other site 573413008165 G3 box; other site 573413008166 Switch II region; other site 573413008167 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 573413008168 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573413008169 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 573413008170 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413008171 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573413008172 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573413008173 RNA binding surface [nucleotide binding]; other site 573413008174 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573413008175 active site 573413008176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573413008177 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413008178 catalytic residue [active] 573413008179 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 573413008180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573413008181 active site 573413008182 Int/Topo IB signature motif; other site 573413008183 DNA binding site [nucleotide binding] 573413008184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413008185 non-specific DNA binding site [nucleotide binding]; other site 573413008186 salt bridge; other site 573413008187 sequence-specific DNA binding site [nucleotide binding]; other site 573413008188 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573413008189 MPN+ (JAMM) motif; other site 573413008190 Zinc-binding site [ion binding]; other site 573413008191 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573413008192 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 573413008193 Phage capsid family; Region: Phage_capsid; pfam05065 573413008194 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 573413008195 Phage portal protein; Region: Phage_portal; pfam04860 573413008196 Phage-related protein [Function unknown]; Region: COG4695 573413008197 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 573413008198 Phage terminase, small subunit; Region: Terminase_4; pfam05119 573413008199 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573413008200 Ligand Binding Site [chemical binding]; other site 573413008201 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413008202 CRISPR/Cas system-associated RAMP superfamily protein Csf2; Region: Csf2_U; cl11864 573413008203 CRISPR/Cas system-associated protein Csf1; Region: Csf1_U; cd09705 573413008204 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413008205 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413008206 dimer interface [polypeptide binding]; other site 573413008207 ssDNA binding site [nucleotide binding]; other site 573413008208 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413008209 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573413008210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413008211 ATP binding site [chemical binding]; other site 573413008212 putative Mg++ binding site [ion binding]; other site 573413008213 DNA methylase; Region: N6_N4_Mtase; cl17433 573413008214 RecT family; Region: RecT; cl04285 573413008215 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573413008216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413008217 non-specific DNA binding site [nucleotide binding]; other site 573413008218 salt bridge; other site 573413008219 sequence-specific DNA binding site [nucleotide binding]; other site 573413008220 DNA polymerase X family; Region: POLXc; smart00483 573413008221 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 573413008222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573413008223 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 573413008224 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413008225 metal binding site [ion binding]; metal-binding site 573413008226 active site 573413008227 I-site; other site 573413008228 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573413008229 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413008230 catalytic residues [active] 573413008231 elongation factor G; Reviewed; Region: PRK00007 573413008232 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573413008233 G1 box; other site 573413008234 putative GEF interaction site [polypeptide binding]; other site 573413008235 GTP/Mg2+ binding site [chemical binding]; other site 573413008236 Switch I region; other site 573413008237 G2 box; other site 573413008238 G3 box; other site 573413008239 Switch II region; other site 573413008240 G4 box; other site 573413008241 G5 box; other site 573413008242 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573413008243 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 573413008244 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573413008245 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 573413008246 elongation factor G; Reviewed; Region: PRK12740 573413008247 G1 box; other site 573413008248 putative GEF interaction site [polypeptide binding]; other site 573413008249 GTP/Mg2+ binding site [chemical binding]; other site 573413008250 Switch I region; other site 573413008251 G2 box; other site 573413008252 G3 box; other site 573413008253 Switch II region; other site 573413008254 G4 box; other site 573413008255 G5 box; other site 573413008256 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573413008257 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573413008258 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573413008259 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113 573413008260 dimer interface [polypeptide binding]; other site 573413008261 Citrate synthase; Region: Citrate_synt; pfam00285 573413008262 active site 573413008263 citrylCoA binding site [chemical binding]; other site 573413008264 oxalacetate/citrate binding site [chemical binding]; other site 573413008265 coenzyme A binding site [chemical binding]; other site 573413008266 catalytic triad [active] 573413008267 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413008268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413008269 S-adenosylmethionine binding site [chemical binding]; other site 573413008270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413008271 GAF domain; Region: GAF; pfam01590 573413008272 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573413008273 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573413008274 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413008275 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413008276 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573413008277 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573413008278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413008279 ATP binding site [chemical binding]; other site 573413008280 putative Mg++ binding site [ion binding]; other site 573413008281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413008282 nucleotide binding region [chemical binding]; other site 573413008283 ATP-binding site [chemical binding]; other site 573413008284 TRCF domain; Region: TRCF; pfam03461 573413008285 PilZ domain; Region: PilZ; pfam07238 573413008286 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 573413008287 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413008288 FeS/SAM binding site; other site 573413008289 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 573413008290 Beta-lactamase; Region: Beta-lactamase; pfam00144 573413008291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413008292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413008293 DNA binding residues [nucleotide binding] 573413008294 The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843 573413008295 TM1410 hypothetical-related protein; Region: DUF297; cl00997 573413008296 Bacterial SH3 domain; Region: SH3_3; pfam08239 573413008297 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573413008298 Cyclophilin-like; Region: Cyclophil_like; cl17583 573413008299 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 573413008300 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 573413008301 Acetokinase family; Region: Acetate_kinase; cl17229 573413008302 propionate/acetate kinase; Provisional; Region: PRK12379 573413008303 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 573413008304 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573413008305 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 573413008306 membrane protein FdrA; Validated; Region: PRK06091 573413008307 CoA binding domain; Region: CoA_binding; pfam02629 573413008308 CoA-ligase; Region: Ligase_CoA; pfam00549 573413008309 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 573413008310 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 573413008311 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413008312 Walker A/P-loop; other site 573413008313 ATP binding site [chemical binding]; other site 573413008314 Q-loop/lid; other site 573413008315 ABC transporter signature motif; other site 573413008316 Walker B; other site 573413008317 D-loop; other site 573413008318 H-loop/switch region; other site 573413008319 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413008320 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413008321 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413008322 Walker A/P-loop; other site 573413008323 ATP binding site [chemical binding]; other site 573413008324 Q-loop/lid; other site 573413008325 ABC transporter signature motif; other site 573413008326 Walker B; other site 573413008327 D-loop; other site 573413008328 H-loop/switch region; other site 573413008329 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573413008330 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573413008331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413008332 dimer interface [polypeptide binding]; other site 573413008333 conserved gate region; other site 573413008334 putative PBP binding loops; other site 573413008335 ABC-ATPase subunit interface; other site 573413008336 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413008337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413008338 dimer interface [polypeptide binding]; other site 573413008339 conserved gate region; other site 573413008340 putative PBP binding loops; other site 573413008341 ABC-ATPase subunit interface; other site 573413008342 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413008343 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 573413008344 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573413008345 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 573413008346 putative ligand binding site [chemical binding]; other site 573413008347 putative NAD binding site [chemical binding]; other site 573413008348 catalytic site [active] 573413008349 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413008350 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 573413008351 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413008352 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413008353 DNA-binding site [nucleotide binding]; DNA binding site 573413008354 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573413008355 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413008356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413008357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413008358 active site 573413008359 catalytic tetrad [active] 573413008360 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413008361 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413008362 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413008363 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 573413008364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413008365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413008366 DNA binding site [nucleotide binding] 573413008367 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413008368 dimerization interface [polypeptide binding]; other site 573413008369 ligand binding site [chemical binding]; other site 573413008370 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573413008371 EamA-like transporter family; Region: EamA; pfam00892 573413008372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413008373 putative substrate translocation pore; other site 573413008374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413008375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413008376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008377 ATP binding site [chemical binding]; other site 573413008378 Mg2+ binding site [ion binding]; other site 573413008379 G-X-G motif; other site 573413008380 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413008381 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413008382 ligand binding site [chemical binding]; other site 573413008383 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 573413008384 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 573413008385 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413008386 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573413008387 intersubunit interface [polypeptide binding]; other site 573413008388 active site 573413008389 zinc binding site [ion binding]; other site 573413008390 Na+ binding site [ion binding]; other site 573413008391 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573413008392 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573413008393 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573413008394 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573413008395 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573413008396 23S rRNA binding site [nucleotide binding]; other site 573413008397 L21 binding site [polypeptide binding]; other site 573413008398 L13 binding site [polypeptide binding]; other site 573413008399 endonuclease subunit; Provisional; Region: 46; PHA02562 573413008400 Cell division protein ZapA; Region: ZapA; pfam05164 573413008401 PilZ domain; Region: PilZ; pfam07238 573413008402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008403 TPR motif; other site 573413008404 binding surface 573413008405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413008406 TPR repeat; Region: TPR_11; pfam13414 573413008407 binding surface 573413008408 TPR motif; other site 573413008409 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573413008410 flagellin; Provisional; Region: PRK12804 573413008411 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573413008412 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573413008413 flagellin; Provisional; Region: PRK12804 573413008414 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573413008415 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 573413008416 FlaG protein; Region: FlaG; pfam03646 573413008417 flagellar hook-associated protein FliD; Validated; Region: fliD; PRK06664 573413008418 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 573413008419 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 573413008420 PilZ domain; Region: PilZ; pfam07238 573413008421 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 573413008422 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573413008423 Glycoprotease family; Region: Peptidase_M22; pfam00814 573413008424 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413008425 Zn2+ binding site [ion binding]; other site 573413008426 Mg2+ binding site [ion binding]; other site 573413008427 carbon storage regulator; Provisional; Region: PRK01712 573413008428 flagellar assembly protein FliW; Provisional; Region: PRK13285 573413008429 flagellar hook-associated protein FlgL; Validated; Region: PRK06663 573413008430 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 573413008431 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06665 573413008432 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 573413008433 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 573413008434 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573413008435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413008436 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413008437 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573413008438 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573413008439 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573413008440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573413008441 Coenzyme A binding pocket [chemical binding]; other site 573413008442 glycogen synthase; Provisional; Region: glgA; PRK00654 573413008443 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 573413008444 ADP-binding pocket [chemical binding]; other site 573413008445 homodimer interface [polypeptide binding]; other site 573413008446 RNase_H superfamily; Region: RNase_H_2; pfam13482 573413008447 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 573413008448 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413008449 ATP binding site [chemical binding]; other site 573413008450 putative Mg++ binding site [ion binding]; other site 573413008451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413008452 nucleotide binding region [chemical binding]; other site 573413008453 ATP-binding site [chemical binding]; other site 573413008454 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 573413008455 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 573413008456 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573413008457 ligand binding site; other site 573413008458 oligomer interface; other site 573413008459 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573413008460 dimer interface [polypeptide binding]; other site 573413008461 N-terminal domain interface [polypeptide binding]; other site 573413008462 sulfate 1 binding site; other site 573413008463 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573413008464 active site 573413008465 8-oxo-dGMP binding site [chemical binding]; other site 573413008466 nudix motif; other site 573413008467 metal binding site [ion binding]; metal-binding site 573413008468 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 573413008469 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573413008470 putative substrate binding site [chemical binding]; other site 573413008471 putative ATP binding site [chemical binding]; other site 573413008472 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573413008473 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573413008474 SEC-C motif; Region: SEC-C; pfam02810 573413008475 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413008476 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413008477 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413008478 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413008479 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573413008480 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573413008481 Catalytic site [active] 573413008482 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573413008483 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573413008484 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573413008485 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 573413008486 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 573413008487 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573413008488 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 573413008489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413008490 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413008491 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573413008492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 573413008493 active site residue [active] 573413008494 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 573413008495 CPxP motif; other site 573413008496 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 573413008497 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 573413008498 putative active site [active] 573413008499 homotetrameric interface [polypeptide binding]; other site 573413008500 metal binding site [ion binding]; metal-binding site 573413008501 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573413008502 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573413008503 NAD(P) binding site [chemical binding]; other site 573413008504 catalytic residues [active] 573413008505 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 573413008506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413008507 putative active site [active] 573413008508 heme pocket [chemical binding]; other site 573413008509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413008510 Walker A motif; other site 573413008511 ATP binding site [chemical binding]; other site 573413008512 Walker B motif; other site 573413008513 arginine finger; other site 573413008514 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413008515 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413008516 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573413008517 active site 573413008518 metal binding site [ion binding]; metal-binding site 573413008519 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413008520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413008521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413008522 WHG domain; Region: WHG; pfam13305 573413008523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413008524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413008525 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 573413008526 putative dimerization interface [polypeptide binding]; other site 573413008527 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 573413008528 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 573413008529 active site 573413008530 catalytic residues [active] 573413008531 metal binding site [ion binding]; metal-binding site 573413008532 Cache domain; Region: Cache_1; pfam02743 573413008533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413008534 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 573413008535 putative ligand binding site [chemical binding]; other site 573413008536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413008538 TM-ABC transporter signature motif; other site 573413008539 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413008540 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413008541 Walker A/P-loop; other site 573413008542 ATP binding site [chemical binding]; other site 573413008543 Q-loop/lid; other site 573413008544 ABC transporter signature motif; other site 573413008545 Walker B; other site 573413008546 D-loop; other site 573413008547 H-loop/switch region; other site 573413008548 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413008549 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413008550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413008551 ABC transporter signature motif; other site 573413008552 Walker B; other site 573413008553 D-loop; other site 573413008554 H-loop/switch region; other site 573413008555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413008556 Walker A/P-loop; other site 573413008557 ATP binding site [chemical binding]; other site 573413008558 Q-loop/lid; other site 573413008559 ABC transporter signature motif; other site 573413008560 Walker B; other site 573413008561 D-loop; other site 573413008562 H-loop/switch region; other site 573413008563 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573413008564 Histidine kinase; Region: His_kinase; pfam06580 573413008565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008566 ATP binding site [chemical binding]; other site 573413008567 Mg2+ binding site [ion binding]; other site 573413008568 G-X-G motif; other site 573413008569 Response regulator receiver domain; Region: Response_reg; pfam00072 573413008570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413008571 active site 573413008572 phosphorylation site [posttranslational modification] 573413008573 intermolecular recognition site; other site 573413008574 dimerization interface [polypeptide binding]; other site 573413008575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413008576 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413008577 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413008578 Cache domain; Region: Cache_1; pfam02743 573413008579 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573413008580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413008581 dimerization interface [polypeptide binding]; other site 573413008582 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413008583 dimer interface [polypeptide binding]; other site 573413008584 putative CheW interface [polypeptide binding]; other site 573413008585 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573413008586 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573413008587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413008588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413008589 dimer interface [polypeptide binding]; other site 573413008590 conserved gate region; other site 573413008591 putative PBP binding loops; other site 573413008592 ABC-ATPase subunit interface; other site 573413008593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413008594 dimer interface [polypeptide binding]; other site 573413008595 conserved gate region; other site 573413008596 putative PBP binding loops; other site 573413008597 ABC-ATPase subunit interface; other site 573413008598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413008599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413008600 Predicted transcriptional regulator [Transcription]; Region: COG4189 573413008601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413008602 dimerization interface [polypeptide binding]; other site 573413008603 putative DNA binding site [nucleotide binding]; other site 573413008604 putative Zn2+ binding site [ion binding]; other site 573413008605 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 573413008606 B12 binding site [chemical binding]; other site 573413008607 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413008608 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573413008609 FeS/SAM binding site; other site 573413008610 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 573413008611 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413008612 DRTGG domain; Region: DRTGG; pfam07085 573413008613 CBS domain; Region: CBS; pfam00571 573413008614 DHH family; Region: DHH; pfam01368 573413008615 DHHA2 domain; Region: DHHA2; pfam02833 573413008616 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 573413008617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413008618 Histidine kinase; Region: HisKA_3; pfam07730 573413008619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008620 ATP binding site [chemical binding]; other site 573413008621 Mg2+ binding site [ion binding]; other site 573413008622 G-X-G motif; other site 573413008623 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413008624 substrate binding site [chemical binding]; other site 573413008625 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413008626 ATP binding site [chemical binding]; other site 573413008627 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 573413008628 active site 573413008629 catalytic motif [active] 573413008630 Zn binding site [ion binding]; other site 573413008631 peptidase; Reviewed; Region: PRK13004 573413008632 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413008633 metal binding site [ion binding]; metal-binding site 573413008634 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008635 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413008636 TM-ABC transporter signature motif; other site 573413008637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008638 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413008639 TM-ABC transporter signature motif; other site 573413008640 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413008641 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413008642 Walker A/P-loop; other site 573413008643 ATP binding site [chemical binding]; other site 573413008644 Q-loop/lid; other site 573413008645 ABC transporter signature motif; other site 573413008646 Walker B; other site 573413008647 D-loop; other site 573413008648 H-loop/switch region; other site 573413008649 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413008650 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413008651 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 573413008652 ligand binding site [chemical binding]; other site 573413008653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413008654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413008655 putative substrate translocation pore; other site 573413008656 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 573413008657 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413008658 active site 573413008659 putative substrate binding pocket [chemical binding]; other site 573413008660 RibD C-terminal domain; Region: RibD_C; cl17279 573413008661 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413008662 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413008663 DNA binding site [nucleotide binding] 573413008664 domain linker motif; other site 573413008665 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413008666 ligand binding site [chemical binding]; other site 573413008667 dimerization interface [polypeptide binding]; other site 573413008668 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573413008669 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 573413008670 CoenzymeA binding site [chemical binding]; other site 573413008671 subunit interaction site [polypeptide binding]; other site 573413008672 PHB binding site; other site 573413008673 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 573413008674 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 573413008675 trimer interface [polypeptide binding]; other site 573413008676 putative metal binding site [ion binding]; other site 573413008677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573413008678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413008679 NAD(P) binding site [chemical binding]; other site 573413008680 active site 573413008681 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008682 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413008683 TM-ABC transporter signature motif; other site 573413008684 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413008685 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413008686 Walker A/P-loop; other site 573413008687 ATP binding site [chemical binding]; other site 573413008688 Q-loop/lid; other site 573413008689 ABC transporter signature motif; other site 573413008690 Walker B; other site 573413008691 D-loop; other site 573413008692 H-loop/switch region; other site 573413008693 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413008694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413008695 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413008696 ligand binding site [chemical binding]; other site 573413008697 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 573413008698 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 573413008699 putative NAD(P) binding site [chemical binding]; other site 573413008700 catalytic Zn binding site [ion binding]; other site 573413008701 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413008702 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413008703 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413008704 NAD(P) binding site [chemical binding]; other site 573413008705 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413008706 intersubunit interface [polypeptide binding]; other site 573413008707 active site 573413008708 zinc binding site [ion binding]; other site 573413008709 Na+ binding site [ion binding]; other site 573413008710 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413008711 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413008712 substrate binding site [chemical binding]; other site 573413008713 ATP binding site [chemical binding]; other site 573413008714 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413008715 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573413008716 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413008717 Family description; Region: ACT_7; pfam13840 573413008718 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554 573413008719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413008720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413008721 active site 573413008722 phosphorylation site [posttranslational modification] 573413008723 intermolecular recognition site; other site 573413008724 dimerization interface [polypeptide binding]; other site 573413008725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413008726 DNA binding site [nucleotide binding] 573413008727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413008728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413008729 dimer interface [polypeptide binding]; other site 573413008730 phosphorylation site [posttranslational modification] 573413008731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008732 ATP binding site [chemical binding]; other site 573413008733 Mg2+ binding site [ion binding]; other site 573413008734 G-X-G motif; other site 573413008735 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 573413008736 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 573413008737 active pocket/dimerization site; other site 573413008738 active site 573413008739 phosphorylation site [posttranslational modification] 573413008740 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573413008741 dimerization domain swap beta strand [polypeptide binding]; other site 573413008742 regulatory protein interface [polypeptide binding]; other site 573413008743 active site 573413008744 regulatory phosphorylation site [posttranslational modification]; other site 573413008745 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573413008746 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573413008747 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413008748 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413008749 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 573413008750 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 573413008751 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 573413008752 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 573413008753 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573413008754 SelR domain; Region: SelR; pfam01641 573413008755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413008756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413008757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413008758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413008759 active site 573413008760 phosphorylation site [posttranslational modification] 573413008761 intermolecular recognition site; other site 573413008762 dimerization interface [polypeptide binding]; other site 573413008763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413008764 DNA binding residues [nucleotide binding] 573413008765 dimerization interface [polypeptide binding]; other site 573413008766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413008767 Histidine kinase; Region: HisKA_3; pfam07730 573413008768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008769 ATP binding site [chemical binding]; other site 573413008770 Mg2+ binding site [ion binding]; other site 573413008771 G-X-G motif; other site 573413008772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413008773 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413008774 ligand binding site [chemical binding]; other site 573413008775 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413008776 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413008777 Walker A/P-loop; other site 573413008778 ATP binding site [chemical binding]; other site 573413008779 Q-loop/lid; other site 573413008780 ABC transporter signature motif; other site 573413008781 Walker B; other site 573413008782 D-loop; other site 573413008783 H-loop/switch region; other site 573413008784 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413008785 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008786 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413008787 TM-ABC transporter signature motif; other site 573413008788 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413008789 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 573413008790 putative ligand binding residues [chemical binding]; other site 573413008791 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413008792 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413008793 ABC-ATPase subunit interface; other site 573413008794 dimer interface [polypeptide binding]; other site 573413008795 putative PBP binding regions; other site 573413008796 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413008797 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573413008798 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 573413008799 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 573413008800 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 573413008801 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573413008802 DNA binding site [nucleotide binding] 573413008803 active site 573413008804 flavodoxin; Provisional; Region: PRK06242 573413008805 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573413008806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413008807 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 573413008808 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573413008809 homotrimer interaction site [polypeptide binding]; other site 573413008810 putative active site [active] 573413008811 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 573413008812 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573413008813 ADP binding site [chemical binding]; other site 573413008814 magnesium binding site [ion binding]; other site 573413008815 putative shikimate binding site; other site 573413008816 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 573413008817 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413008818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413008819 nucleotide binding site [chemical binding]; other site 573413008820 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413008821 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 573413008822 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 573413008823 active site 573413008824 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 573413008825 Transcriptional regulators [Transcription]; Region: GntR; COG1802 573413008826 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413008827 DNA-binding site [nucleotide binding]; DNA binding site 573413008828 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573413008829 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413008830 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 573413008831 metal binding site [ion binding]; metal-binding site 573413008832 putative dimer interface [polypeptide binding]; other site 573413008833 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 573413008834 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413008835 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413008836 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413008837 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413008838 catalytic loop [active] 573413008839 iron binding site [ion binding]; other site 573413008840 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413008841 probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316 573413008842 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573413008843 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573413008844 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413008845 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413008846 catalytic loop [active] 573413008847 iron binding site [ion binding]; other site 573413008848 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413008849 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 573413008850 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 573413008851 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573413008852 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413008853 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413008854 phenylhydantoinase; Validated; Region: PRK08323 573413008855 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413008856 active site 573413008857 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573413008858 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 573413008859 phosphate binding site [ion binding]; other site 573413008860 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573413008861 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413008862 4Fe-4S binding domain; Region: Fer4; pfam00037 573413008863 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413008864 D-xylulose kinase; Region: XylB; TIGR01312 573413008865 nucleotide binding site [chemical binding]; other site 573413008866 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413008867 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413008868 NAD(P) binding site [chemical binding]; other site 573413008869 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 573413008870 Class I aldolases; Region: Aldolase_Class_I; cl17187 573413008871 catalytic residue [active] 573413008872 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413008873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413008874 DNA-binding site [nucleotide binding]; DNA binding site 573413008875 UTRA domain; Region: UTRA; pfam07702 573413008876 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573413008877 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 573413008878 NAD(P) binding site [chemical binding]; other site 573413008879 catalytic residues [active] 573413008880 FecR protein; Region: FecR; pfam04773 573413008881 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413008882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413008883 ligand binding site [chemical binding]; other site 573413008884 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 573413008885 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 573413008886 Ca binding site [ion binding]; other site 573413008887 active site 573413008888 catalytic site [active] 573413008889 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 573413008890 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413008891 catalytic loop [active] 573413008892 iron binding site [ion binding]; other site 573413008893 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 573413008894 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 573413008895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413008896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413008897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413008898 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 573413008899 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 573413008900 B12 binding site [chemical binding]; other site 573413008901 cobalt ligand [ion binding]; other site 573413008902 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 573413008903 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 573413008904 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 573413008905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413008906 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 573413008907 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 573413008908 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 573413008909 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 573413008910 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573413008911 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573413008912 putative valine binding site [chemical binding]; other site 573413008913 dimer interface [polypeptide binding]; other site 573413008914 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573413008915 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 573413008916 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573413008917 PYR/PP interface [polypeptide binding]; other site 573413008918 dimer interface [polypeptide binding]; other site 573413008919 TPP binding site [chemical binding]; other site 573413008920 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573413008921 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 573413008922 TPP-binding site [chemical binding]; other site 573413008923 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 573413008924 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 573413008925 active site 573413008926 multimer interface [polypeptide binding]; other site 573413008927 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 573413008928 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 573413008929 substrate-cofactor binding pocket; other site 573413008930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413008931 catalytic residue [active] 573413008932 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; Region: KDSR-like_SDR_c; cd08939 573413008933 putative NAD(P) binding site [chemical binding]; other site 573413008934 homotetramer interface [polypeptide binding]; other site 573413008935 active site 573413008936 homodimer interface [polypeptide binding]; other site 573413008937 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413008938 MarR family; Region: MarR_2; pfam12802 573413008939 MarR family; Region: MarR_2; cl17246 573413008940 peptidase; Reviewed; Region: PRK13004 573413008941 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413008942 metal binding site [ion binding]; metal-binding site 573413008943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413008944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413008945 dimerization interface [polypeptide binding]; other site 573413008946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413008947 dimer interface [polypeptide binding]; other site 573413008948 phosphorylation site [posttranslational modification] 573413008949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413008950 ATP binding site [chemical binding]; other site 573413008951 Mg2+ binding site [ion binding]; other site 573413008952 G-X-G motif; other site 573413008953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413008954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413008955 active site 573413008956 phosphorylation site [posttranslational modification] 573413008957 intermolecular recognition site; other site 573413008958 dimerization interface [polypeptide binding]; other site 573413008959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413008960 DNA binding site [nucleotide binding] 573413008961 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573413008962 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413008963 ATP binding site [chemical binding]; other site 573413008964 putative Mg++ binding site [ion binding]; other site 573413008965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413008966 nucleotide binding region [chemical binding]; other site 573413008967 ATP-binding site [chemical binding]; other site 573413008968 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573413008969 NlpC/P60 family; Region: NLPC_P60; pfam00877 573413008970 MORN repeat; Region: MORN; cl14787 573413008971 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 573413008972 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573413008973 active site 573413008974 Putative phosphatase (DUF442); Region: DUF442; cl17385 573413008975 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573413008976 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008977 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413008978 TM-ABC transporter signature motif; other site 573413008979 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413008980 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413008981 TM-ABC transporter signature motif; other site 573413008982 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413008983 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413008984 Walker A/P-loop; other site 573413008985 ATP binding site [chemical binding]; other site 573413008986 Q-loop/lid; other site 573413008987 ABC transporter signature motif; other site 573413008988 Walker B; other site 573413008989 D-loop; other site 573413008990 H-loop/switch region; other site 573413008991 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413008992 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413008993 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 573413008994 putative ligand binding site [chemical binding]; other site 573413008995 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 573413008996 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573413008997 nucleotide binding site [chemical binding]; other site 573413008998 substrate binding site [chemical binding]; other site 573413008999 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 573413009000 dimer interface [polypeptide binding]; other site 573413009001 putative threonine allosteric regulatory site; other site 573413009002 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 573413009003 putative threonine allosteric regulatory site; other site 573413009004 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573413009005 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573413009006 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573413009007 Hpt domain; Region: Hpt; pfam01627 573413009008 putative binding surface; other site 573413009009 active site 573413009010 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 573413009012 active site 573413009013 phosphorylation site [posttranslational modification] 573413009014 intermolecular recognition site; other site 573413009015 dimerization interface [polypeptide binding]; other site 573413009016 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009018 active site 573413009019 phosphorylation site [posttranslational modification] 573413009020 intermolecular recognition site; other site 573413009021 dimerization interface [polypeptide binding]; other site 573413009022 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413009023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413009024 metal binding site [ion binding]; metal-binding site 573413009025 active site 573413009026 I-site; other site 573413009027 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 573413009028 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 573413009029 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 573413009030 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573413009031 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573413009032 minor groove reading motif; other site 573413009033 helix-hairpin-helix signature motif; other site 573413009034 substrate binding pocket [chemical binding]; other site 573413009035 active site 573413009036 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 573413009037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573413009038 active site 573413009039 DNA binding site [nucleotide binding] 573413009040 Int/Topo IB signature motif; other site 573413009041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413009042 non-specific DNA binding site [nucleotide binding]; other site 573413009043 salt bridge; other site 573413009044 sequence-specific DNA binding site [nucleotide binding]; other site 573413009045 Helix-turn-helix domain; Region: HTH_17; pfam12728 573413009046 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413009047 non-specific DNA binding site [nucleotide binding]; other site 573413009048 salt bridge; other site 573413009049 sequence-specific DNA binding site [nucleotide binding]; other site 573413009050 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 573413009051 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 573413009052 AAA domain; Region: AAA_24; pfam13479 573413009053 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573413009054 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413009055 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413009056 dimer interface [polypeptide binding]; other site 573413009057 ssDNA binding site [nucleotide binding]; other site 573413009058 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413009059 large terminase protein; Provisional; Region: 17; PHA02533 573413009060 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 573413009061 hypothetical protein; Region: PHA00670 573413009062 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 573413009063 putative protease; Region: PHA00666 573413009064 major capsid protein; Region: PHA00665 573413009065 hypothetical protein; Region: PHA00664 573413009066 hypothetical protein; Region: PHA00662 573413009067 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 573413009068 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 573413009069 crystallin beta/gamma motif-containing protein; Region: PHA00657 573413009070 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 573413009071 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573413009072 structural tetrad; other site 573413009073 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 573413009074 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 573413009075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413009076 AAA domain; Region: AAA_22; pfam13401 573413009077 Walker A motif; other site 573413009078 ATP binding site [chemical binding]; other site 573413009079 Walker B motif; other site 573413009080 arginine finger; other site 573413009081 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916 573413009082 TIR domain; Region: TIR_2; pfam13676 573413009083 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573413009084 MULE transposase domain; Region: MULE; pfam10551 573413009085 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 573413009086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413009087 Coenzyme A binding pocket [chemical binding]; other site 573413009088 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413009089 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 573413009090 Predicted transcriptional regulators [Transcription]; Region: COG1733 573413009091 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573413009092 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 573413009093 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 573413009094 putative NAD(P) binding site [chemical binding]; other site 573413009095 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 573413009096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573413009097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413009098 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 573413009099 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 573413009100 4Fe-4S binding domain; Region: Fer4; pfam00037 573413009101 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 573413009102 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413009103 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 573413009104 metal binding site [ion binding]; metal-binding site 573413009105 dimer interface [polypeptide binding]; other site 573413009106 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 573413009107 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413009108 active site 573413009109 putative substrate binding pocket [chemical binding]; other site 573413009110 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009111 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 573413009112 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 573413009113 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413009114 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413009115 Walker A/P-loop; other site 573413009116 ATP binding site [chemical binding]; other site 573413009117 Q-loop/lid; other site 573413009118 ABC transporter signature motif; other site 573413009119 Walker B; other site 573413009120 D-loop; other site 573413009121 H-loop/switch region; other site 573413009122 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413009123 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413009124 Walker A/P-loop; other site 573413009125 ATP binding site [chemical binding]; other site 573413009126 Q-loop/lid; other site 573413009127 ABC transporter signature motif; other site 573413009128 Walker B; other site 573413009129 D-loop; other site 573413009130 H-loop/switch region; other site 573413009131 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413009132 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573413009133 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 573413009134 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009135 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 573413009136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009137 DNA-binding site [nucleotide binding]; DNA binding site 573413009138 UTRA domain; Region: UTRA; cl17743 573413009139 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 573413009140 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 573413009141 substrate binding pocket [chemical binding]; other site 573413009142 dimer interface [polypeptide binding]; other site 573413009143 inhibitor binding site; inhibition site 573413009144 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 573413009145 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cl00249 573413009146 trimer interface I [polypeptide binding]; other site 573413009147 putative substrate binding pocket [chemical binding]; other site 573413009148 trimer interface II [polypeptide binding]; other site 573413009149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009150 DNA-binding site [nucleotide binding]; DNA binding site 573413009151 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413009152 UTRA domain; Region: UTRA; cl17743 573413009153 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009155 active site 573413009156 phosphorylation site [posttranslational modification] 573413009157 intermolecular recognition site; other site 573413009158 dimerization interface [polypeptide binding]; other site 573413009159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413009160 Histidine kinase; Region: HisKA_2; pfam07568 573413009161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009162 ATP binding site [chemical binding]; other site 573413009163 Mg2+ binding site [ion binding]; other site 573413009164 G-X-G motif; other site 573413009165 PAS fold; Region: PAS; pfam00989 573413009166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413009167 putative active site [active] 573413009168 heme pocket [chemical binding]; other site 573413009169 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413009170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413009171 putative active site [active] 573413009172 heme pocket [chemical binding]; other site 573413009173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413009174 dimer interface [polypeptide binding]; other site 573413009175 phosphorylation site [posttranslational modification] 573413009176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009177 ATP binding site [chemical binding]; other site 573413009178 Mg2+ binding site [ion binding]; other site 573413009179 G-X-G motif; other site 573413009180 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413009181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009182 active site 573413009183 phosphorylation site [posttranslational modification] 573413009184 intermolecular recognition site; other site 573413009185 dimerization interface [polypeptide binding]; other site 573413009186 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 573413009187 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 573413009188 molybdopterin cofactor binding site; other site 573413009189 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 573413009190 molybdopterin cofactor binding site; other site 573413009191 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 573413009192 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 573413009193 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413009194 ATP binding site [chemical binding]; other site 573413009195 putative Mg++ binding site [ion binding]; other site 573413009196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413009197 nucleotide binding region [chemical binding]; other site 573413009198 ATP-binding site [chemical binding]; other site 573413009199 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 573413009200 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 573413009201 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 573413009202 active site 573413009203 catalytic residue [active] 573413009204 dimer interface [polypeptide binding]; other site 573413009205 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 573413009206 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573413009207 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573413009208 shikimate binding site; other site 573413009209 NAD(P) binding site [chemical binding]; other site 573413009210 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 573413009211 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 573413009212 isocitrate dehydrogenase; Validated; Region: PRK07362 573413009213 Tetratricopeptide repeat; Region: TPR_6; pfam13174 573413009214 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573413009215 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573413009216 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413009217 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413009218 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573413009219 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413009220 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413009221 ABC transporter; Region: ABC_tran_2; pfam12848 573413009222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573413009223 Maf-like protein; Reviewed; Region: PRK00078 573413009224 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573413009225 active site 573413009226 dimer interface [polypeptide binding]; other site 573413009227 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573413009228 rRNA interaction site [nucleotide binding]; other site 573413009229 S8 interaction site; other site 573413009230 putative laminin-1 binding site; other site 573413009231 elongation factor Ts; Provisional; Region: tsf; PRK09377 573413009232 UBA/TS-N domain; Region: UBA; pfam00627 573413009233 Elongation factor TS; Region: EF_TS; pfam00889 573413009234 Elongation factor TS; Region: EF_TS; pfam00889 573413009235 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573413009236 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573413009237 hinge region; other site 573413009238 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 573413009239 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 573413009240 catalytic residue [active] 573413009241 putative FPP diphosphate binding site; other site 573413009242 putative FPP binding hydrophobic cleft; other site 573413009243 dimer interface [polypeptide binding]; other site 573413009244 putative IPP diphosphate binding site; other site 573413009245 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573413009246 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 573413009247 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573413009248 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573413009249 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573413009250 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573413009251 RIP metalloprotease RseP; Region: TIGR00054 573413009252 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 573413009253 active site 573413009254 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573413009255 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 573413009256 protein binding site [polypeptide binding]; other site 573413009257 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 573413009258 putative substrate binding region [chemical binding]; other site 573413009259 CpXC protein; Region: CpXC; pfam14353 573413009260 FOG: WD40 repeat [General function prediction only]; Region: COG2319 573413009261 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 573413009262 structural tetrad; other site 573413009263 Late competence development protein ComFB; Region: ComFB; pfam10719 573413009264 replicative DNA helicase; Region: DnaB; TIGR00665 573413009265 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573413009266 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573413009267 Walker A motif; other site 573413009268 ATP binding site [chemical binding]; other site 573413009269 Walker B motif; other site 573413009270 DNA binding loops [nucleotide binding] 573413009271 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573413009272 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573413009273 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573413009274 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573413009275 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413009276 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413009277 dimer interface [polypeptide binding]; other site 573413009278 ssDNA binding site [nucleotide binding]; other site 573413009279 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413009280 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573413009281 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 573413009282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413009283 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 573413009284 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 573413009285 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413009286 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 573413009287 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573413009288 TPP-binding site; other site 573413009289 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 573413009290 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573413009291 PYR/PP interface [polypeptide binding]; other site 573413009292 dimer interface [polypeptide binding]; other site 573413009293 TPP binding site [chemical binding]; other site 573413009294 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413009295 Flagellar L-ring protein; Region: FlgH; cl17277 573413009296 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 573413009297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573413009298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573413009299 FemAB family; Region: FemAB; pfam02388 573413009300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573413009301 probable methionyl-tRNA synthetase; Region: PLN02610 573413009302 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573413009303 active site 573413009304 HIGH motif; other site 573413009305 KMSKS motif; other site 573413009306 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573413009307 tRNA binding surface [nucleotide binding]; other site 573413009308 anticodon binding site; other site 573413009309 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cd02153 573413009310 putative tRNA-binding site [nucleotide binding]; other site 573413009311 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 573413009312 HflK protein; Region: hflK; TIGR01933 573413009313 HflC protein; Region: hflC; TIGR01932 573413009314 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 573413009315 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 573413009316 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 573413009317 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 573413009318 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573413009319 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573413009320 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573413009321 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573413009322 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573413009323 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 573413009324 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573413009325 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 573413009326 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573413009327 FMN binding site [chemical binding]; other site 573413009328 dimer interface [polypeptide binding]; other site 573413009329 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573413009330 active site 573413009331 DNA polymerase IV; Validated; Region: PRK02406 573413009332 DNA binding site [nucleotide binding] 573413009333 Uncharacterized conserved protein [Function unknown]; Region: COG3391 573413009334 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 573413009335 Strictosidine synthase; Region: Str_synth; pfam03088 573413009336 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573413009337 NlpC/P60 family; Region: NLPC_P60; cl17555 573413009338 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573413009339 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573413009340 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 573413009341 seryl-tRNA synthetase; Provisional; Region: PRK05431 573413009342 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573413009343 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573413009344 dimer interface [polypeptide binding]; other site 573413009345 active site 573413009346 motif 1; other site 573413009347 motif 2; other site 573413009348 motif 3; other site 573413009349 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 573413009350 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 573413009351 active site 573413009352 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 573413009353 NeuB family; Region: NeuB; pfam03102 573413009354 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 573413009355 NeuB binding interface [polypeptide binding]; other site 573413009356 putative substrate binding site [chemical binding]; other site 573413009357 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009359 active site 573413009360 phosphorylation site [posttranslational modification] 573413009361 intermolecular recognition site; other site 573413009362 dimerization interface [polypeptide binding]; other site 573413009363 Chemotaxis phosphatase CheX; Region: CheX; cl15816 573413009364 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009366 active site 573413009367 phosphorylation site [posttranslational modification] 573413009368 intermolecular recognition site; other site 573413009369 dimerization interface [polypeptide binding]; other site 573413009370 CheD chemotactic sensory transduction; Region: CheD; cl00810 573413009371 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573413009372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009373 active site 573413009374 phosphorylation site [posttranslational modification] 573413009375 intermolecular recognition site; other site 573413009376 dimerization interface [polypeptide binding]; other site 573413009377 CheB methylesterase; Region: CheB_methylest; pfam01339 573413009378 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 573413009379 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 573413009380 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573413009381 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413009382 putative binding surface; other site 573413009383 active site 573413009384 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413009385 putative binding surface; other site 573413009386 active site 573413009387 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573413009388 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573413009389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009390 ATP binding site [chemical binding]; other site 573413009391 Mg2+ binding site [ion binding]; other site 573413009392 G-X-G motif; other site 573413009393 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573413009394 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413009395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009396 active site 573413009397 phosphorylation site [posttranslational modification] 573413009398 intermolecular recognition site; other site 573413009399 dimerization interface [polypeptide binding]; other site 573413009400 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413009401 dimer interface [polypeptide binding]; other site 573413009402 putative CheW interface [polypeptide binding]; other site 573413009403 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 573413009404 anti sigma factor interaction site; other site 573413009405 regulatory phosphorylation site [posttranslational modification]; other site 573413009406 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573413009407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009408 active site 573413009409 phosphorylation site [posttranslational modification] 573413009410 intermolecular recognition site; other site 573413009411 dimerization interface [polypeptide binding]; other site 573413009412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413009413 Zn2+ binding site [ion binding]; other site 573413009414 Mg2+ binding site [ion binding]; other site 573413009415 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009417 active site 573413009418 phosphorylation site [posttranslational modification] 573413009419 intermolecular recognition site; other site 573413009420 dimerization interface [polypeptide binding]; other site 573413009421 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 573413009422 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 573413009423 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 573413009424 putative CheA interaction surface; other site 573413009425 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 573413009426 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 573413009427 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413009428 putative binding surface; other site 573413009429 active site 573413009430 P2 response regulator binding domain; Region: P2; pfam07194 573413009431 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 573413009432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009433 ATP binding site [chemical binding]; other site 573413009434 G-X-G motif; other site 573413009435 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 573413009436 Flagellar filament outer layer protein Flaa; Region: FlaA; pfam04620 573413009437 Sporulation and spore germination; Region: Germane; pfam10646 573413009438 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 573413009439 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 573413009440 active site 573413009441 metal binding site [ion binding]; metal-binding site 573413009442 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 573413009443 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573413009444 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573413009445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413009446 S-adenosylmethionine binding site [chemical binding]; other site 573413009447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413009448 active site 573413009449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413009450 active site 573413009451 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 573413009452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413009453 FeS/SAM binding site; other site 573413009454 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 573413009455 gamma-glutamyl kinase; Provisional; Region: PRK05429 573413009456 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573413009457 nucleotide binding site [chemical binding]; other site 573413009458 homotetrameric interface [polypeptide binding]; other site 573413009459 putative phosphate binding site [ion binding]; other site 573413009460 putative allosteric binding site; other site 573413009461 PUA domain; Region: PUA; pfam01472 573413009462 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573413009463 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573413009464 putative catalytic cysteine [active] 573413009465 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009467 active site 573413009468 phosphorylation site [posttranslational modification] 573413009469 intermolecular recognition site; other site 573413009470 dimerization interface [polypeptide binding]; other site 573413009471 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 573413009472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413009473 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 573413009474 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 573413009475 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 573413009476 XdhC Rossmann domain; Region: XdhC_C; pfam13478 573413009477 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 573413009478 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 573413009479 selenophosphate synthetase; Provisional; Region: PRK00943 573413009480 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 573413009481 dimerization interface [polypeptide binding]; other site 573413009482 putative ATP binding site [chemical binding]; other site 573413009483 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 573413009484 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 573413009485 CPxP motif; other site 573413009486 DsrE/DsrF-like family; Region: DrsE; pfam02635 573413009487 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413009488 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413009489 intersubunit interface [polypeptide binding]; other site 573413009490 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413009491 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413009492 ABC-ATPase subunit interface; other site 573413009493 dimer interface [polypeptide binding]; other site 573413009494 putative PBP binding regions; other site 573413009495 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413009496 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413009497 Walker A/P-loop; other site 573413009498 ATP binding site [chemical binding]; other site 573413009499 Q-loop/lid; other site 573413009500 ABC transporter signature motif; other site 573413009501 Walker B; other site 573413009502 D-loop; other site 573413009503 H-loop/switch region; other site 573413009504 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 573413009505 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009506 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 573413009507 active site 573413009508 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 573413009509 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 573413009510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009511 active site 573413009512 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009513 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573413009514 Predicted transcriptional regulator [Transcription]; Region: COG1959 573413009515 Transcriptional regulator; Region: Rrf2; pfam02082 573413009516 Homoserine O-succinyltransferase; Region: HTS; pfam04204 573413009517 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 573413009518 proposed active site lysine [active] 573413009519 conserved cys residue [active] 573413009520 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573413009521 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573413009522 homodimer interface [polypeptide binding]; other site 573413009523 substrate-cofactor binding pocket; other site 573413009524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413009525 catalytic residue [active] 573413009526 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573413009527 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573413009528 dimer interface [polypeptide binding]; other site 573413009529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413009530 catalytic residue [active] 573413009531 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 573413009532 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 573413009533 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 573413009534 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 573413009535 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 573413009536 xanthine permease; Region: pbuX; TIGR03173 573413009537 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573413009538 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 573413009539 Cl- selectivity filter; other site 573413009540 Cl- binding residues [ion binding]; other site 573413009541 pore gating glutamate residue; other site 573413009542 dimer interface [polypeptide binding]; other site 573413009543 H+/Cl- coupling transport residue; other site 573413009544 TrkA-C domain; Region: TrkA_C; pfam02080 573413009545 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 573413009546 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573413009547 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413009548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009549 DNA-binding site [nucleotide binding]; DNA binding site 573413009550 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 573413009551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413009552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413009553 dimer interface [polypeptide binding]; other site 573413009554 conserved gate region; other site 573413009555 ABC-ATPase subunit interface; other site 573413009556 alpha-galactosidase; Provisional; Region: PRK15076 573413009557 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 573413009558 NAD(P) binding site [chemical binding]; other site 573413009559 LDH/MDH dimer interface [polypeptide binding]; other site 573413009560 substrate binding site [chemical binding]; other site 573413009561 Sodium Bile acid symporter family; Region: SBF; cl17470 573413009562 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 573413009563 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413009564 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413009565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413009566 substrate binding site [chemical binding]; other site 573413009567 ATP binding site [chemical binding]; other site 573413009568 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 573413009569 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413009570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413009571 DNA binding site [nucleotide binding] 573413009572 domain linker motif; other site 573413009573 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413009574 dimerization interface [polypeptide binding]; other site 573413009575 ligand binding site [chemical binding]; other site 573413009576 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 573413009577 biotin synthase; Provisional; Region: PRK07094 573413009578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413009579 FeS/SAM binding site; other site 573413009580 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 573413009581 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 573413009582 Carbon starvation protein CstA; Region: CstA; pfam02554 573413009583 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573413009584 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 573413009585 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 573413009586 P loop; other site 573413009587 Nucleotide binding site [chemical binding]; other site 573413009588 DTAP/Switch II; other site 573413009589 Switch I; other site 573413009590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413009591 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 573413009592 ATP binding site [chemical binding]; other site 573413009593 putative Mg++ binding site [ion binding]; other site 573413009594 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413009595 nucleotide binding region [chemical binding]; other site 573413009596 ATP-binding site [chemical binding]; other site 573413009597 DEAD/H associated; Region: DEAD_assoc; pfam08494 573413009598 HAMP domain; Region: HAMP; pfam00672 573413009599 dimerization interface [polypeptide binding]; other site 573413009600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413009601 Histidine kinase; Region: HisKA_2; pfam07568 573413009602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009603 ATP binding site [chemical binding]; other site 573413009604 Mg2+ binding site [ion binding]; other site 573413009605 G-X-G motif; other site 573413009606 bHLH-MYC and R2R3-MYB transcription factors N-terminal; Region: bHLH-MYC_N; pfam14215 573413009607 GAF domain; Region: GAF_2; pfam13185 573413009608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413009609 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413009610 dimer interface [polypeptide binding]; other site 573413009611 phosphorylation site [posttranslational modification] 573413009612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413009613 ATP binding site [chemical binding]; other site 573413009614 Mg2+ binding site [ion binding]; other site 573413009615 G-X-G motif; other site 573413009616 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009618 active site 573413009619 phosphorylation site [posttranslational modification] 573413009620 intermolecular recognition site; other site 573413009621 dimerization interface [polypeptide binding]; other site 573413009622 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 573413009623 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413009624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009625 DNA-binding site [nucleotide binding]; DNA binding site 573413009626 UTRA domain; Region: UTRA; cl17743 573413009627 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413009628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009629 DNA-binding site [nucleotide binding]; DNA binding site 573413009630 UTRA domain; Region: UTRA; cl17743 573413009631 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573413009632 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 573413009633 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573413009634 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 573413009635 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573413009636 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 573413009637 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573413009638 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573413009639 Protein of unknown function (DUF432); Region: DUF432; cl01027 573413009640 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413009641 catalytic residues [active] 573413009642 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413009643 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413009644 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413009645 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413009646 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 573413009647 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573413009648 PYR/PP interface [polypeptide binding]; other site 573413009649 dimer interface [polypeptide binding]; other site 573413009650 TPP binding site [chemical binding]; other site 573413009651 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573413009652 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 573413009653 TPP-binding site [chemical binding]; other site 573413009654 KduI/IolB family; Region: KduI; pfam04962 573413009655 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413009656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413009657 DNA binding site [nucleotide binding] 573413009658 domain linker motif; other site 573413009659 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413009660 dimerization interface [polypeptide binding]; other site 573413009661 ligand binding site [chemical binding]; other site 573413009662 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413009663 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413009664 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413009665 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 573413009666 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573413009667 PYR/PP interface [polypeptide binding]; other site 573413009668 dimer interface [polypeptide binding]; other site 573413009669 TPP binding site [chemical binding]; other site 573413009670 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413009671 transketolase; Reviewed; Region: PRK05899 573413009672 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573413009673 TPP-binding site [chemical binding]; other site 573413009674 dimer interface [polypeptide binding]; other site 573413009675 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413009676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413009677 DNA-binding site [nucleotide binding]; DNA binding site 573413009678 FCD domain; Region: FCD; pfam07729 573413009679 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 573413009680 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413009681 Protein export membrane protein; Region: SecD_SecF; cl14618 573413009682 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573413009683 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413009684 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413009685 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413009686 hypothetical protein; Provisional; Region: PRK10279 573413009687 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 573413009688 nucleophile elbow; other site 573413009689 Surface antigen; Region: Bac_surface_Ag; pfam01103 573413009690 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 573413009691 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573413009692 DNA binding site [nucleotide binding] 573413009693 active site 573413009694 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413009695 dimer interface [polypeptide binding]; other site 573413009696 [2Fe-2S] cluster binding site [ion binding]; other site 573413009697 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 573413009698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413009699 FeS/SAM binding site; other site 573413009700 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 573413009701 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573413009702 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 573413009703 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 573413009704 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573413009705 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573413009706 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 573413009707 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 573413009708 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 573413009709 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573413009710 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573413009711 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573413009712 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573413009713 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 573413009714 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 573413009715 Nucleotide-binding sites [chemical binding]; other site 573413009716 Walker A motif; other site 573413009717 Switch I region of nucleotide binding site; other site 573413009718 Fe4S4 binding sites [ion binding]; other site 573413009719 Switch II region of nucleotide binding site; other site 573413009720 Nif-specific regulatory protein; Region: nifA; TIGR01817 573413009721 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 573413009722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413009723 Walker A motif; other site 573413009724 ATP binding site [chemical binding]; other site 573413009725 Walker B motif; other site 573413009726 arginine finger; other site 573413009727 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 573413009728 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 573413009729 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 573413009730 active site 573413009731 catalytic residues [active] 573413009732 metal binding site [ion binding]; metal-binding site 573413009733 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 573413009734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413009735 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573413009736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413009737 dimer interface [polypeptide binding]; other site 573413009738 conserved gate region; other site 573413009739 putative PBP binding loops; other site 573413009740 ABC-ATPase subunit interface; other site 573413009741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413009742 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 573413009743 Walker A/P-loop; other site 573413009744 ATP binding site [chemical binding]; other site 573413009745 Q-loop/lid; other site 573413009746 ABC transporter signature motif; other site 573413009747 Walker B; other site 573413009748 D-loop; other site 573413009749 H-loop/switch region; other site 573413009750 TOBE domain; Region: TOBE; cl01440 573413009751 Creatinine amidohydrolase; Region: Creatininase; pfam02633 573413009752 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 573413009753 Na binding site [ion binding]; other site 573413009754 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413009755 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413009756 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413009757 putative active site [active] 573413009758 isoaspartyl dipeptidase; Provisional; Region: PRK10657 573413009759 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009760 active site 573413009761 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 573413009762 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573413009763 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413009764 metal binding site [ion binding]; metal-binding site 573413009765 Methyltransferase domain; Region: Methyltransf_23; pfam13489 573413009766 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413009767 S-adenosylmethionine binding site [chemical binding]; other site 573413009768 Predicted transcriptional regulators [Transcription]; Region: COG1695 573413009769 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 573413009770 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573413009771 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413009772 Histidine kinase; Region: HisKA_2; pfam07568 573413009773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573413009774 ATP binding site [chemical binding]; other site 573413009775 Mg2+ binding site [ion binding]; other site 573413009776 G-X-G motif; other site 573413009777 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573413009778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413009779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413009780 DNA binding site [nucleotide binding] 573413009781 domain linker motif; other site 573413009782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413009783 dimerization interface [polypeptide binding]; other site 573413009784 ligand binding site [chemical binding]; other site 573413009785 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413009786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413009787 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413009788 TM-ABC transporter signature motif; other site 573413009789 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413009790 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413009791 Walker A/P-loop; other site 573413009792 ATP binding site [chemical binding]; other site 573413009793 Q-loop/lid; other site 573413009794 ABC transporter signature motif; other site 573413009795 Walker B; other site 573413009796 D-loop; other site 573413009797 H-loop/switch region; other site 573413009798 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413009799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413009800 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 573413009801 putative ligand binding site [chemical binding]; other site 573413009802 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573413009803 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413009804 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413009805 nucleotide binding site [chemical binding]; other site 573413009806 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 573413009807 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 573413009808 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 573413009809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413009810 FeS/SAM binding site; other site 573413009811 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 573413009812 SEC-C motif; Region: SEC-C; pfam02810 573413009813 Sulfatase; Region: Sulfatase; cl17466 573413009814 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 573413009815 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 573413009816 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413009817 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 573413009818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413009819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413009820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573413009821 dimerization interface [polypeptide binding]; other site 573413009822 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573413009823 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573413009824 Rhomboid family; Region: Rhomboid; cl11446 573413009825 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573413009826 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413009827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413009828 DNA binding residues [nucleotide binding] 573413009829 dimerization interface [polypeptide binding]; other site 573413009830 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573413009831 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573413009832 RF-1 domain; Region: RF-1; pfam00472 573413009833 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573413009834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413009835 S-adenosylmethionine binding site [chemical binding]; other site 573413009836 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573413009837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413009838 Zn2+ binding site [ion binding]; other site 573413009839 Mg2+ binding site [ion binding]; other site 573413009840 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573413009841 synthetase active site [active] 573413009842 NTP binding site [chemical binding]; other site 573413009843 metal binding site [ion binding]; metal-binding site 573413009844 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573413009845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413009846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413009847 GTP-binding protein YchF; Reviewed; Region: PRK09601 573413009848 YchF GTPase; Region: YchF; cd01900 573413009849 G1 box; other site 573413009850 GTP/Mg2+ binding site [chemical binding]; other site 573413009851 Switch I region; other site 573413009852 G2 box; other site 573413009853 Switch II region; other site 573413009854 G3 box; other site 573413009855 G4 box; other site 573413009856 G5 box; other site 573413009857 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573413009858 exonuclease I; Provisional; Region: sbcB; PRK11779 573413009859 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 573413009860 active site 573413009861 catalytic site [active] 573413009862 substrate binding site [chemical binding]; other site 573413009863 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 573413009864 Predicted permease; Region: DUF318; cl17795 573413009865 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 573413009866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413009867 dimerization interface [polypeptide binding]; other site 573413009868 putative DNA binding site [nucleotide binding]; other site 573413009869 putative Zn2+ binding site [ion binding]; other site 573413009870 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413009871 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413009872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413009873 DNA binding site [nucleotide binding] 573413009874 domain linker motif; other site 573413009875 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413009876 dimerization interface [polypeptide binding]; other site 573413009877 ligand binding site [chemical binding]; other site 573413009878 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413009879 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413009880 substrate binding site [chemical binding]; other site 573413009881 ATP binding site [chemical binding]; other site 573413009882 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573413009883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413009884 motif II; other site 573413009885 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 573413009886 dimerization interface [polypeptide binding]; other site 573413009887 putative active cleft [active] 573413009888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413009889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413009890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413009891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413009892 dimer interface [polypeptide binding]; other site 573413009893 conserved gate region; other site 573413009894 putative PBP binding loops; other site 573413009895 ABC-ATPase subunit interface; other site 573413009896 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413009897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413009898 dimer interface [polypeptide binding]; other site 573413009899 conserved gate region; other site 573413009900 putative PBP binding loops; other site 573413009901 ABC-ATPase subunit interface; other site 573413009902 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413009903 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413009904 nucleotide binding site [chemical binding]; other site 573413009905 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 573413009906 dimer interface [polypeptide binding]; other site 573413009907 active site 573413009908 4Fe-4S binding domain; Region: Fer4; cl02805 573413009909 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 573413009910 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 573413009911 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 573413009912 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 573413009913 Bacterial SH3 domain; Region: SH3_3; pfam08239 573413009914 Caspase domain; Region: Peptidase_C14; pfam00656 573413009915 Fe-S metabolism associated domain; Region: SufE; cl00951 573413009916 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573413009917 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573413009918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413009919 catalytic residue [active] 573413009920 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 573413009921 trimer interface [polypeptide binding]; other site 573413009922 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573413009923 substrate binding site [chemical binding]; other site 573413009924 Mn binding site [ion binding]; other site 573413009925 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 573413009926 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 573413009927 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 573413009928 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413009929 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413009930 ligand binding site [chemical binding]; other site 573413009931 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413009932 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413009933 TM-ABC transporter signature motif; other site 573413009934 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413009935 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413009936 Walker A/P-loop; other site 573413009937 ATP binding site [chemical binding]; other site 573413009938 Q-loop/lid; other site 573413009939 ABC transporter signature motif; other site 573413009940 Walker B; other site 573413009941 D-loop; other site 573413009942 H-loop/switch region; other site 573413009943 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413009944 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573413009945 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573413009946 NAD(P) binding site [chemical binding]; other site 573413009947 catalytic residues [active] 573413009948 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413009949 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413009950 active site 573413009951 NAD binding site [chemical binding]; other site 573413009952 metal binding site [ion binding]; metal-binding site 573413009953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413009954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413009955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573413009956 dimerization interface [polypeptide binding]; other site 573413009957 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573413009958 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573413009959 HflX GTPase family; Region: HflX; cd01878 573413009960 G1 box; other site 573413009961 GTP/Mg2+ binding site [chemical binding]; other site 573413009962 Switch I region; other site 573413009963 G2 box; other site 573413009964 G3 box; other site 573413009965 Switch II region; other site 573413009966 G4 box; other site 573413009967 G5 box; other site 573413009968 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 573413009969 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413009970 active site 573413009971 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 573413009972 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 573413009973 EamA-like transporter family; Region: EamA; pfam00892 573413009974 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573413009975 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573413009976 metal-binding site [ion binding] 573413009977 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573413009978 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573413009979 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573413009980 metal-binding site [ion binding] 573413009981 Response regulator receiver domain; Region: Response_reg; pfam00072 573413009982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413009983 active site 573413009984 phosphorylation site [posttranslational modification] 573413009985 intermolecular recognition site; other site 573413009986 dimerization interface [polypeptide binding]; other site 573413009987 Nudix hydrolase homolog; Region: PLN02791 573413009988 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 573413009989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413009990 FeS/SAM binding site; other site 573413009991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413009992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413009993 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573413009994 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573413009995 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413009996 active site 573413009997 phosphorylation site [posttranslational modification] 573413009998 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573413009999 Ligand Binding Site [chemical binding]; other site 573413010000 ATP synthase subunit D; Region: ATP-synt_D; cl00613 573413010001 V-type ATP synthase subunit B; Provisional; Region: PRK04196 573413010002 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 573413010003 Walker A motif homologous position; other site 573413010004 Walker B motif; other site 573413010005 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573413010006 V-type ATP synthase subunit A; Provisional; Region: PRK04192 573413010007 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573413010008 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 573413010009 Walker A motif/ATP binding site; other site 573413010010 Walker B motif; other site 573413010011 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573413010012 V-type ATP synthase subunit E; Provisional; Region: PRK03963; cl17074 573413010013 ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991 573413010014 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; pfam01990 573413010015 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 573413010016 V-type ATP synthase subunit I; Validated; Region: PRK05771 573413010017 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 573413010018 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 573413010019 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573413010020 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413010021 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413010022 ligand binding site [chemical binding]; other site 573413010023 flexible hinge region; other site 573413010024 Ion channel; Region: Ion_trans_2; pfam07885 573413010025 TrkA-N domain; Region: TrkA_N; pfam02254 573413010026 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 573413010027 fructuronate transporter; Provisional; Region: PRK10034; cl15264 573413010028 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573413010029 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 573413010030 active site 573413010031 hypothetical protein; Validated; Region: PRK00228 573413010032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413010033 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573413010034 FeS/SAM binding site; other site 573413010035 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 573413010036 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 573413010037 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 573413010038 active site 573413010039 substrate binding site [chemical binding]; other site 573413010040 cosubstrate binding site; other site 573413010041 catalytic site [active] 573413010042 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573413010043 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573413010044 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573413010045 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573413010046 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573413010047 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573413010048 dimerization interface [polypeptide binding]; other site 573413010049 putative ATP binding site [chemical binding]; other site 573413010050 amidophosphoribosyltransferase; Provisional; Region: PRK05793 573413010051 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573413010052 active site 573413010053 tetramer interface [polypeptide binding]; other site 573413010054 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413010055 active site 573413010056 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 573413010057 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 573413010058 ATP binding site [chemical binding]; other site 573413010059 active site 573413010060 substrate binding site [chemical binding]; other site 573413010061 AIR carboxylase; Region: AIRC; pfam00731 573413010062 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 573413010063 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573413010064 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573413010065 dimerization interface [polypeptide binding]; other site 573413010066 ATP binding site [chemical binding]; other site 573413010067 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573413010068 dimerization interface [polypeptide binding]; other site 573413010069 ATP binding site [chemical binding]; other site 573413010070 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 573413010071 putative active site [active] 573413010072 catalytic triad [active] 573413010073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413010074 S-adenosylmethionine binding site [chemical binding]; other site 573413010075 Peptidase family M48; Region: Peptidase_M48; pfam01435 573413010076 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 573413010077 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573413010078 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 573413010079 active site 573413010080 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573413010081 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413010082 acyl-activating enzyme (AAE) consensus motif; other site 573413010083 putative AMP binding site [chemical binding]; other site 573413010084 putative active site [active] 573413010085 putative CoA binding site [chemical binding]; other site 573413010086 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 573413010087 FMN binding site [chemical binding]; other site 573413010088 dimer interface [polypeptide binding]; other site 573413010089 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 573413010090 LPP20 lipoprotein; Region: LPP20; cl15824 573413010091 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 573413010092 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573413010093 dimer interface [polypeptide binding]; other site 573413010094 motif 1; other site 573413010095 active site 573413010096 motif 2; other site 573413010097 motif 3; other site 573413010098 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 573413010099 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 573413010100 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 573413010101 putative active site pocket [active] 573413010102 4-fold oligomerization interface [polypeptide binding]; other site 573413010103 metal binding residues [ion binding]; metal-binding site 573413010104 3-fold/trimer interface [polypeptide binding]; other site 573413010105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010106 binding surface 573413010107 TPR motif; other site 573413010108 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573413010109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010110 binding surface 573413010111 TPR motif; other site 573413010112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010113 binding surface 573413010114 TPR motif; other site 573413010115 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010116 binding surface 573413010117 TPR motif; other site 573413010118 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 573413010119 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 573413010120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413010121 FeS/SAM binding site; other site 573413010122 alanyl-tRNA synthetase; Provisional; Region: PRK01584 573413010123 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573413010124 motif 1; other site 573413010125 active site 573413010126 motif 2; other site 573413010127 motif 3; other site 573413010128 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573413010129 TM2 domain; Region: TM2; pfam05154 573413010130 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 573413010131 FliG C-terminal domain; Region: FliG_C; pfam01706 573413010132 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 573413010133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413010134 active site 573413010135 metal binding site [ion binding]; metal-binding site 573413010136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413010137 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573413010138 Walker A/P-loop; other site 573413010139 ATP binding site [chemical binding]; other site 573413010140 Q-loop/lid; other site 573413010141 ABC transporter signature motif; other site 573413010142 Walker B; other site 573413010143 D-loop; other site 573413010144 H-loop/switch region; other site 573413010145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010146 dimer interface [polypeptide binding]; other site 573413010147 conserved gate region; other site 573413010148 putative PBP binding loops; other site 573413010149 ABC-ATPase subunit interface; other site 573413010150 NMT1/THI5 like; Region: NMT1; pfam09084 573413010151 NMT1-like family; Region: NMT1_2; pfam13379 573413010152 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573413010153 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573413010154 active site 573413010155 HIGH motif; other site 573413010156 dimer interface [polypeptide binding]; other site 573413010157 KMSKS motif; other site 573413010158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 573413010159 RNA binding surface [nucleotide binding]; other site 573413010160 glycyl-tRNA synthetase; Provisional; Region: PRK04173 573413010161 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 573413010162 dimer interface [polypeptide binding]; other site 573413010163 motif 1; other site 573413010164 active site 573413010165 motif 2; other site 573413010166 motif 3; other site 573413010167 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 573413010168 anticodon binding site; other site 573413010169 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573413010170 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573413010171 active site 573413010172 HIGH motif; other site 573413010173 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573413010174 active site 573413010175 KMSKS motif; other site 573413010176 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573413010177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413010178 Zn2+ binding site [ion binding]; other site 573413010179 Mg2+ binding site [ion binding]; other site 573413010180 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 573413010181 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 573413010182 active site 573413010183 Predicted permeases [General function prediction only]; Region: COG0679 573413010184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010185 DNA-binding site [nucleotide binding]; DNA binding site 573413010186 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413010187 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573413010188 Walker A/P-loop; other site 573413010189 ATP binding site [chemical binding]; other site 573413010190 Q-loop/lid; other site 573413010191 ABC transporter signature motif; other site 573413010192 Walker B; other site 573413010193 D-loop; other site 573413010194 H-loop/switch region; other site 573413010195 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 573413010196 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 573413010197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413010198 Walker A motif; other site 573413010199 ATP binding site [chemical binding]; other site 573413010200 Walker B motif; other site 573413010201 arginine finger; other site 573413010202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413010203 Walker A motif; other site 573413010204 ATP binding site [chemical binding]; other site 573413010205 Walker B motif; other site 573413010206 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573413010207 Uncharacterized conserved protein [Function unknown]; Region: COG2127 573413010208 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573413010209 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573413010210 trimerization site [polypeptide binding]; other site 573413010211 active site 573413010212 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573413010213 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 573413010214 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 573413010215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413010216 catalytic residue [active] 573413010217 Flagellin N-methylase; Region: FliB; cl00497 573413010218 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 573413010219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010220 binding surface 573413010221 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413010222 TPR motif; other site 573413010223 TPR repeat; Region: TPR_11; pfam13414 573413010224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010225 binding surface 573413010226 TPR motif; other site 573413010227 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 573413010228 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573413010229 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 573413010230 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573413010231 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573413010232 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 573413010233 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573413010234 putative active site [active] 573413010235 catalytic triad [active] 573413010236 putative dimer interface [polypeptide binding]; other site 573413010237 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573413010238 transcription termination factor Rho; Provisional; Region: rho; PRK09376 573413010239 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 573413010240 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 573413010241 RNA binding site [nucleotide binding]; other site 573413010242 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 573413010243 multimer interface [polypeptide binding]; other site 573413010244 Walker A motif; other site 573413010245 ATP binding site [chemical binding]; other site 573413010246 Walker B motif; other site 573413010247 competence damage-inducible protein A; Provisional; Region: PRK00549 573413010248 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 573413010249 putative MPT binding site; other site 573413010250 Competence-damaged protein; Region: CinA; pfam02464 573413010251 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573413010252 Response regulator receiver domain; Region: Response_reg; pfam00072 573413010253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413010254 active site 573413010255 phosphorylation site [posttranslational modification] 573413010256 intermolecular recognition site; other site 573413010257 dimerization interface [polypeptide binding]; other site 573413010258 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 573413010259 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573413010260 putative active site [active] 573413010261 catalytic triad [active] 573413010262 putative dimer interface [polypeptide binding]; other site 573413010263 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573413010264 IHF - DNA interface [nucleotide binding]; other site 573413010265 IHF dimer interface [polypeptide binding]; other site 573413010266 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573413010267 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 573413010268 Protein of unknown function (DUF327); Region: DUF327; pfam03885 573413010269 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 573413010270 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 573413010271 Lipoprotein; Region: Lipoprotein_6; pfam01441 573413010272 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 573413010273 Peptidase family M23; Region: Peptidase_M23; pfam01551 573413010274 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573413010275 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 573413010276 active site 573413010277 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 573413010278 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573413010279 FMN binding site [chemical binding]; other site 573413010280 active site 573413010281 catalytic residues [active] 573413010282 substrate binding site [chemical binding]; other site 573413010283 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573413010284 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573413010285 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573413010286 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573413010287 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573413010288 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 573413010289 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573413010290 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 573413010291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573413010292 HSP70 interaction site [polypeptide binding]; other site 573413010293 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 573413010294 substrate binding site [polypeptide binding]; other site 573413010295 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573413010296 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573413010297 dimer interface [polypeptide binding]; other site 573413010298 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573413010299 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 573413010300 nucleotide binding site [chemical binding]; other site 573413010301 NEF interaction site [polypeptide binding]; other site 573413010302 SBD interface [polypeptide binding]; other site 573413010303 Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432 573413010304 GrpE; Region: GrpE; pfam01025 573413010305 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573413010306 dimer interface [polypeptide binding]; other site 573413010307 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573413010308 V-type ATP synthase subunit I; Validated; Region: PRK05771 573413010309 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573413010310 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 573413010311 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573413010312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413010313 motif II; other site 573413010314 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 573413010315 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 573413010316 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 573413010317 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 573413010318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413010319 binding surface 573413010320 TPR motif; other site 573413010321 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573413010322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413010323 binding surface 573413010324 TPR motif; other site 573413010325 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 573413010326 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573413010327 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573413010328 DNA binding residues [nucleotide binding] 573413010329 GTP-binding protein Der; Reviewed; Region: PRK00093 573413010330 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573413010331 G1 box; other site 573413010332 GTP/Mg2+ binding site [chemical binding]; other site 573413010333 Switch I region; other site 573413010334 G2 box; other site 573413010335 Switch II region; other site 573413010336 G3 box; other site 573413010337 G4 box; other site 573413010338 G5 box; other site 573413010339 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573413010340 G1 box; other site 573413010341 GTP/Mg2+ binding site [chemical binding]; other site 573413010342 Switch I region; other site 573413010343 G2 box; other site 573413010344 G3 box; other site 573413010345 Switch II region; other site 573413010346 G4 box; other site 573413010347 G5 box; other site 573413010348 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573413010349 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573413010350 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413010351 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413010352 Sporulation and spore germination; Region: Germane; pfam10646 573413010353 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 573413010354 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 573413010355 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573413010356 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 573413010357 putative active site [active] 573413010358 metal binding site [ion binding]; metal-binding site 573413010359 homodimer binding site [polypeptide binding]; other site 573413010360 ribonuclease Y; Region: RNase_Y; TIGR03319 573413010361 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413010362 Zn2+ binding site [ion binding]; other site 573413010363 Mg2+ binding site [ion binding]; other site 573413010364 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573413010365 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573413010366 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573413010367 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413010368 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413010369 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 573413010370 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573413010371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010373 dimer interface [polypeptide binding]; other site 573413010374 conserved gate region; other site 573413010375 putative PBP binding loops; other site 573413010376 ABC-ATPase subunit interface; other site 573413010377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010378 dimer interface [polypeptide binding]; other site 573413010379 conserved gate region; other site 573413010380 putative PBP binding loops; other site 573413010381 ABC-ATPase subunit interface; other site 573413010382 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413010383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413010384 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413010385 MarR family; Region: MarR_2; pfam12802 573413010386 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413010387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413010388 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 573413010389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 573413010390 active site 573413010391 motif I; other site 573413010392 motif II; other site 573413010393 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 573413010394 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 573413010395 putative ADP-binding pocket [chemical binding]; other site 573413010396 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573413010397 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 573413010398 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 573413010399 active site 573413010400 Zn binding site [ion binding]; other site 573413010401 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 573413010402 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573413010403 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573413010404 active site 573413010405 dimer interface [polypeptide binding]; other site 573413010406 motif 1; other site 573413010407 motif 2; other site 573413010408 motif 3; other site 573413010409 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573413010410 anticodon binding site; other site 573413010411 acyl-CoA esterase; Provisional; Region: PRK10673 573413010412 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 573413010413 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 573413010414 aspartate racemase; Region: asp_race; TIGR00035 573413010415 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 573413010416 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413010417 active site 573413010418 motif I; other site 573413010419 motif II; other site 573413010420 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413010421 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 573413010422 putative FMN binding site [chemical binding]; other site 573413010423 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 573413010424 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 573413010425 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 573413010426 Protein export membrane protein; Region: SecD_SecF; pfam02355 573413010427 protein-export membrane protein SecD; Region: secD; TIGR01129 573413010428 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 573413010429 Preprotein translocase subunit; Region: YajC; pfam02699 573413010430 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573413010431 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573413010432 ring oligomerisation interface [polypeptide binding]; other site 573413010433 ATP/Mg binding site [chemical binding]; other site 573413010434 stacking interactions; other site 573413010435 hinge regions; other site 573413010436 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573413010437 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573413010438 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 573413010439 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 573413010440 Arginine repressor [Transcription]; Region: ArgR; COG1438 573413010441 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 573413010442 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 573413010443 argininosuccinate synthase; Provisional; Region: PRK13820 573413010444 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573413010445 ANP binding site [chemical binding]; other site 573413010446 Substrate Binding Site II [chemical binding]; other site 573413010447 Substrate Binding Site I [chemical binding]; other site 573413010448 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 573413010449 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573413010450 active site 573413010451 dimer interface [polypeptide binding]; other site 573413010452 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573413010453 dimer interface [polypeptide binding]; other site 573413010454 active site 573413010455 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573413010456 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413010457 dimer interface [polypeptide binding]; other site 573413010458 putative CheW interface [polypeptide binding]; other site 573413010459 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 573413010460 6-phosphofructokinase; Region: PLN02884 573413010461 active site 573413010462 ADP/pyrophosphate binding site [chemical binding]; other site 573413010463 dimerization interface [polypeptide binding]; other site 573413010464 allosteric effector site; other site 573413010465 fructose-1,6-bisphosphate binding site; other site 573413010466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010467 PAS domain; Region: PAS_9; pfam13426 573413010468 putative active site [active] 573413010469 heme pocket [chemical binding]; other site 573413010470 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413010471 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413010472 metal binding site [ion binding]; metal-binding site 573413010473 active site 573413010474 I-site; other site 573413010475 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573413010476 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 573413010477 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 573413010478 putative metal binding site [ion binding]; other site 573413010479 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 573413010480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413010481 Divergent PAP2 family; Region: DUF212; pfam02681 573413010482 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413010483 HEAT repeats; Region: HEAT_2; pfam13646 573413010484 arginine decarboxylase; Provisional; Region: PRK05354 573413010485 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 573413010486 dimer interface [polypeptide binding]; other site 573413010487 active site 573413010488 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573413010489 catalytic residues [active] 573413010490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573413010491 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573413010492 DNA binding site [nucleotide binding] 573413010493 active site 573413010494 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573413010495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413010496 active site 573413010497 catalytic tetrad [active] 573413010498 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413010499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413010500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010501 DNA-binding site [nucleotide binding]; DNA binding site 573413010502 FCD domain; Region: FCD; pfam07729 573413010503 galactonate dehydratase; Provisional; Region: PRK14017 573413010504 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 573413010505 active site pocket [active] 573413010506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413010507 putative substrate translocation pore; other site 573413010508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413010509 Predicted membrane protein [Function unknown]; Region: COG1288 573413010510 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 573413010511 alpha-glucosidase; Provisional; Region: PRK10426 573413010512 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 573413010513 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 573413010514 putative active site [active] 573413010515 putative catalytic site [active] 573413010516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010518 dimer interface [polypeptide binding]; other site 573413010519 conserved gate region; other site 573413010520 putative PBP binding loops; other site 573413010521 ABC-ATPase subunit interface; other site 573413010522 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010524 dimer interface [polypeptide binding]; other site 573413010525 conserved gate region; other site 573413010526 putative PBP binding loops; other site 573413010527 ABC-ATPase subunit interface; other site 573413010528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413010529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413010530 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 573413010531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413010532 active site 573413010533 phosphorylation site [posttranslational modification] 573413010534 intermolecular recognition site; other site 573413010535 dimerization interface [polypeptide binding]; other site 573413010536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413010537 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573413010538 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573413010539 Histidine kinase; Region: His_kinase; pfam06580 573413010540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413010541 ATP binding site [chemical binding]; other site 573413010542 Mg2+ binding site [ion binding]; other site 573413010543 G-X-G motif; other site 573413010544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413010545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413010546 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573413010547 Walker A/P-loop; other site 573413010548 ATP binding site [chemical binding]; other site 573413010549 Q-loop/lid; other site 573413010550 ABC transporter signature motif; other site 573413010551 Walker B; other site 573413010552 D-loop; other site 573413010553 H-loop/switch region; other site 573413010554 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413010555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413010556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413010557 Walker A/P-loop; other site 573413010558 ATP binding site [chemical binding]; other site 573413010559 Q-loop/lid; other site 573413010560 ABC transporter signature motif; other site 573413010561 Walker B; other site 573413010562 D-loop; other site 573413010563 H-loop/switch region; other site 573413010564 MarR family; Region: MarR_2; pfam12802 573413010565 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413010566 Short C-terminal domain; Region: SHOCT; pfam09851 573413010567 Predicted membrane protein [Function unknown]; Region: COG3462 573413010568 Short C-terminal domain; Region: SHOCT; pfam09851 573413010569 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 573413010570 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573413010571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413010572 motif II; other site 573413010573 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573413010574 putative dimer interface [polypeptide binding]; other site 573413010575 [2Fe-2S] cluster binding site [ion binding]; other site 573413010576 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 573413010577 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573413010578 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413010579 GAF domain; Region: GAF; pfam01590 573413010580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413010581 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573413010582 intersubunit interface [polypeptide binding]; other site 573413010583 active site 573413010584 Zn2+ binding site [ion binding]; other site 573413010585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 573413010586 Uncharacterized conserved protein [Function unknown]; Region: COG1359 573413010587 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 573413010588 tartrate dehydrogenase; Region: TTC; TIGR02089 573413010589 DctM-like transporters; Region: DctM; pfam06808 573413010590 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573413010591 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 573413010592 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413010593 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 573413010594 transcriptional regulator NanR; Provisional; Region: PRK03837 573413010595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010596 DNA-binding site [nucleotide binding]; DNA binding site 573413010597 FCD domain; Region: FCD; pfam07729 573413010598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413010599 Walker B; other site 573413010600 D-loop; other site 573413010601 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413010602 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 573413010603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413010604 catalytic residue [active] 573413010605 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413010606 dimer interface [polypeptide binding]; other site 573413010607 putative CheW interface [polypeptide binding]; other site 573413010608 Uncharacterized conserved protein [Function unknown]; Region: COG3287 573413010609 FIST N domain; Region: FIST; pfam08495 573413010610 FIST C domain; Region: FIST_C; pfam10442 573413010611 Predicted membrane protein [Function unknown]; Region: COG2855 573413010612 glycerate kinase; Region: TIGR00045 573413010613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413010614 binding surface 573413010615 TPR motif; other site 573413010616 fructuronate transporter; Provisional; Region: PRK10034; cl15264 573413010617 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 573413010618 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 573413010619 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413010620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010621 DNA-binding site [nucleotide binding]; DNA binding site 573413010622 FCD domain; Region: FCD; pfam07729 573413010623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573413010624 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413010625 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413010626 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573413010627 Walker A/P-loop; other site 573413010628 ATP binding site [chemical binding]; other site 573413010629 Q-loop/lid; other site 573413010630 ABC transporter signature motif; other site 573413010631 Walker B; other site 573413010632 D-loop; other site 573413010633 H-loop/switch region; other site 573413010634 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413010635 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573413010636 FtsX-like permease family; Region: FtsX; pfam02687 573413010637 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573413010638 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 573413010639 putative metal binding site [ion binding]; other site 573413010640 dimer interface [polypeptide binding]; other site 573413010641 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 573413010642 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413010643 substrate binding pocket [chemical binding]; other site 573413010644 membrane-bound complex binding site; other site 573413010645 hinge residues; other site 573413010646 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 573413010647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010648 conserved gate region; other site 573413010649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010650 putative PBP binding loops; other site 573413010651 dimer interface [polypeptide binding]; other site 573413010652 ABC-ATPase subunit interface; other site 573413010653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010654 dimer interface [polypeptide binding]; other site 573413010655 conserved gate region; other site 573413010656 putative PBP binding loops; other site 573413010657 ABC-ATPase subunit interface; other site 573413010658 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413010659 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413010660 Walker A/P-loop; other site 573413010661 ATP binding site [chemical binding]; other site 573413010662 Q-loop/lid; other site 573413010663 ABC transporter signature motif; other site 573413010664 Walker B; other site 573413010665 D-loop; other site 573413010666 H-loop/switch region; other site 573413010667 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573413010668 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 573413010669 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 573413010670 putative deacylase active site [active] 573413010671 MAC/Perforin domain; Region: MACPF; cl02616 573413010672 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413010673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573413010674 substrate binding pocket [chemical binding]; other site 573413010675 membrane-bound complex binding site; other site 573413010676 hinge residues; other site 573413010677 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573413010678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010679 dimer interface [polypeptide binding]; other site 573413010680 conserved gate region; other site 573413010681 putative PBP binding loops; other site 573413010682 ABC-ATPase subunit interface; other site 573413010683 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573413010684 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573413010685 Walker A/P-loop; other site 573413010686 ATP binding site [chemical binding]; other site 573413010687 Q-loop/lid; other site 573413010688 ABC transporter signature motif; other site 573413010689 Walker B; other site 573413010690 D-loop; other site 573413010691 H-loop/switch region; other site 573413010692 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010693 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010694 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010695 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010696 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010697 FG-GAP repeat; Region: FG-GAP_2; pfam14312 573413010698 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573413010699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413010700 active site 573413010701 catalytic tetrad [active] 573413010702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413010703 Peptidase family C69; Region: Peptidase_C69; cl17793 573413010704 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573413010705 active site 573413010706 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573413010707 active site 2 [active] 573413010708 active site 1 [active] 573413010709 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 573413010710 AMMECR1; Region: AMMECR1; cl00911 573413010711 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 573413010712 putative ligand binding pocket/active site [active] 573413010713 putative metal binding site [ion binding]; other site 573413010714 Protein of unknown function (DUF3160); Region: DUF3160; pfam11369 573413010715 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 573413010716 Na binding site [ion binding]; other site 573413010717 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413010718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413010719 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 573413010720 Protein export membrane protein; Region: SecD_SecF; cl14618 573413010721 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 573413010722 FMN-binding domain; Region: FMN_bind; pfam04205 573413010723 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413010724 L-aspartate oxidase; Provisional; Region: PRK06175 573413010725 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573413010726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413010727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413010728 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010730 dimer interface [polypeptide binding]; other site 573413010731 conserved gate region; other site 573413010732 putative PBP binding loops; other site 573413010733 ABC-ATPase subunit interface; other site 573413010734 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413010735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010736 ABC-ATPase subunit interface; other site 573413010737 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 573413010738 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 573413010739 citrylCoA binding site [chemical binding]; other site 573413010740 oxalacetate binding site [chemical binding]; other site 573413010741 coenzyme A binding site [chemical binding]; other site 573413010742 catalytic triad [active] 573413010743 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 573413010744 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 573413010745 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 573413010746 CoA binding domain; Region: CoA_binding_2; pfam13380 573413010747 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 573413010748 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 573413010749 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413010750 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413010751 DNA binding site [nucleotide binding] 573413010752 domain linker motif; other site 573413010753 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413010754 dimerization interface [polypeptide binding]; other site 573413010755 ligand binding site [chemical binding]; other site 573413010756 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 573413010757 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413010758 active site 573413010759 catalytic tetrad [active] 573413010760 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413010761 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413010762 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413010763 active site 573413010764 catalytic tetrad [active] 573413010765 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573413010766 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 573413010767 DNA binding residues [nucleotide binding] 573413010768 putative dimer interface [polypeptide binding]; other site 573413010769 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413010770 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413010771 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010772 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413010773 putative active site [active] 573413010774 heme pocket [chemical binding]; other site 573413010775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010776 putative active site [active] 573413010777 heme pocket [chemical binding]; other site 573413010778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413010779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413010780 ATP binding site [chemical binding]; other site 573413010781 Mg2+ binding site [ion binding]; other site 573413010782 G-X-G motif; other site 573413010783 Response regulator receiver domain; Region: Response_reg; pfam00072 573413010784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413010785 active site 573413010786 phosphorylation site [posttranslational modification] 573413010787 intermolecular recognition site; other site 573413010788 dimerization interface [polypeptide binding]; other site 573413010789 LabA_like proteins; Region: LabA_like; cd06167 573413010790 putative metal binding site [ion binding]; other site 573413010791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413010792 dimerization interface [polypeptide binding]; other site 573413010793 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 573413010794 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 573413010795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413010796 Zn2+ binding site [ion binding]; other site 573413010797 Mg2+ binding site [ion binding]; other site 573413010798 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573413010799 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573413010800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413010801 Walker A/P-loop; other site 573413010802 ATP binding site [chemical binding]; other site 573413010803 Q-loop/lid; other site 573413010804 ABC transporter signature motif; other site 573413010805 Walker B; other site 573413010806 D-loop; other site 573413010807 H-loop/switch region; other site 573413010808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413010809 non-specific DNA binding site [nucleotide binding]; other site 573413010810 salt bridge; other site 573413010811 sequence-specific DNA binding site [nucleotide binding]; other site 573413010812 Cupin domain; Region: Cupin_2; pfam07883 573413010813 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 573413010814 butyrate kinase; Provisional; Region: PRK03011 573413010815 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 573413010816 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 573413010817 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 573413010818 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 573413010819 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 573413010820 dimer interface [polypeptide binding]; other site 573413010821 PYR/PP interface [polypeptide binding]; other site 573413010822 TPP binding site [chemical binding]; other site 573413010823 substrate binding site [chemical binding]; other site 573413010824 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 573413010825 TPP-binding site; other site 573413010826 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573413010827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413010828 putative DNA binding site [nucleotide binding]; other site 573413010829 putative Zn2+ binding site [ion binding]; other site 573413010830 AsnC family; Region: AsnC_trans_reg; pfam01037 573413010831 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 573413010832 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010834 dimer interface [polypeptide binding]; other site 573413010835 conserved gate region; other site 573413010836 putative PBP binding loops; other site 573413010837 ABC-ATPase subunit interface; other site 573413010838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010839 dimer interface [polypeptide binding]; other site 573413010840 conserved gate region; other site 573413010841 putative PBP binding loops; other site 573413010842 ABC-ATPase subunit interface; other site 573413010843 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413010844 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413010845 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573413010846 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573413010847 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413010848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010849 DNA-binding site [nucleotide binding]; DNA binding site 573413010850 UTRA domain; Region: UTRA; pfam07702 573413010851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413010852 non-specific DNA binding site [nucleotide binding]; other site 573413010853 salt bridge; other site 573413010854 sequence-specific DNA binding site [nucleotide binding]; other site 573413010855 Domain of unknown function (DUF955); Region: DUF955; pfam06114 573413010856 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573413010857 active site 573413010858 NTP binding site [chemical binding]; other site 573413010859 metal binding triad [ion binding]; metal-binding site 573413010860 antibiotic binding site [chemical binding]; other site 573413010861 benzoate transporter; Region: benE; TIGR00843 573413010862 Class I aldolases; Region: Aldolase_Class_I; cl17187 573413010863 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 573413010864 catalytic residue [active] 573413010865 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413010866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413010867 DNA-binding site [nucleotide binding]; DNA binding site 573413010868 FCD domain; Region: FCD; pfam07729 573413010869 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413010870 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 573413010871 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 573413010872 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573413010873 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 573413010874 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 573413010875 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 573413010876 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 573413010877 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 573413010878 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573413010879 NAD(P) binding site [chemical binding]; other site 573413010880 catalytic residues [active] 573413010881 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413010882 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 573413010883 active site 573413010884 metal binding site [ion binding]; metal-binding site 573413010885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413010886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413010887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573413010888 dimerization interface [polypeptide binding]; other site 573413010889 Helix-turn-helix domain; Region: HTH_18; pfam12833 573413010890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413010891 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 573413010892 classical (c) SDRs; Region: SDR_c; cd05233 573413010893 NAD(P) binding site [chemical binding]; other site 573413010894 active site 573413010895 PAS domain; Region: PAS_9; pfam13426 573413010896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010897 putative active site [active] 573413010898 heme pocket [chemical binding]; other site 573413010899 PAS fold; Region: PAS_3; pfam08447 573413010900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010901 PAS domain; Region: PAS_9; pfam13426 573413010902 putative active site [active] 573413010903 heme pocket [chemical binding]; other site 573413010904 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413010905 Zn2+ binding site [ion binding]; other site 573413010906 Mg2+ binding site [ion binding]; other site 573413010907 Cache domain; Region: Cache_1; pfam02743 573413010908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413010909 dimerization interface [polypeptide binding]; other site 573413010910 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413010911 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413010912 dimer interface [polypeptide binding]; other site 573413010913 putative CheW interface [polypeptide binding]; other site 573413010914 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413010915 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413010916 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413010917 putative active site [active] 573413010918 heme pocket [chemical binding]; other site 573413010919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413010920 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413010921 DNA binding residues [nucleotide binding] 573413010922 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413010923 intersubunit interface [polypeptide binding]; other site 573413010924 active site 573413010925 zinc binding site [ion binding]; other site 573413010926 Na+ binding site [ion binding]; other site 573413010927 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010929 dimer interface [polypeptide binding]; other site 573413010930 conserved gate region; other site 573413010931 putative PBP binding loops; other site 573413010932 ABC-ATPase subunit interface; other site 573413010933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010934 dimer interface [polypeptide binding]; other site 573413010935 conserved gate region; other site 573413010936 putative PBP binding loops; other site 573413010937 ABC-ATPase subunit interface; other site 573413010938 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413010939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413010940 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413010941 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 573413010942 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413010943 ADP-specific Phosphofructokinase/Glucokinase conserved region; Region: ADP_PFK_GK; cl14060 573413010944 ADP-dependent glucokinase; Provisional; Region: PRK14039 573413010945 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413010946 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413010947 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413010948 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 573413010949 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 573413010950 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413010951 Response regulator receiver domain; Region: Response_reg; pfam00072 573413010952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413010953 active site 573413010954 phosphorylation site [posttranslational modification] 573413010955 intermolecular recognition site; other site 573413010956 dimerization interface [polypeptide binding]; other site 573413010957 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413010958 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413010959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413010960 Histidine kinase; Region: HisKA_2; pfam07568 573413010961 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573413010962 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573413010963 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 573413010964 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573413010965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413010966 dimer interface [polypeptide binding]; other site 573413010967 putative CheW interface [polypeptide binding]; other site 573413010968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413010969 non-specific DNA binding site [nucleotide binding]; other site 573413010970 salt bridge; other site 573413010971 sequence-specific DNA binding site [nucleotide binding]; other site 573413010972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413010973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010974 dimer interface [polypeptide binding]; other site 573413010975 conserved gate region; other site 573413010976 putative PBP binding loops; other site 573413010977 ABC-ATPase subunit interface; other site 573413010978 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 573413010979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413010980 putative PBP binding loops; other site 573413010981 dimer interface [polypeptide binding]; other site 573413010982 ABC-ATPase subunit interface; other site 573413010983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413010984 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413010985 Response regulator receiver domain; Region: Response_reg; pfam00072 573413010986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413010987 active site 573413010988 phosphorylation site [posttranslational modification] 573413010989 intermolecular recognition site; other site 573413010990 dimerization interface [polypeptide binding]; other site 573413010991 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573413010992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413010993 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573413010994 HAMP domain; Region: HAMP; pfam00672 573413010995 Histidine kinase; Region: His_kinase; pfam06580 573413010996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413010997 ATP binding site [chemical binding]; other site 573413010998 Mg2+ binding site [ion binding]; other site 573413010999 G-X-G motif; other site 573413011000 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413011001 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413011002 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 573413011003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 573413011004 FeS/SAM binding site; other site 573413011005 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 573413011006 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 573413011007 Aspartase; Region: Aspartase; cd01357 573413011008 active sites [active] 573413011009 tetramer interface [polypeptide binding]; other site 573413011010 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 573413011011 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 573413011012 G1 box; other site 573413011013 GTP/Mg2+ binding site [chemical binding]; other site 573413011014 Switch I region; other site 573413011015 G2 box; other site 573413011016 Switch II region; other site 573413011017 G3 box; other site 573413011018 G4 box; other site 573413011019 G5 box; other site 573413011020 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011021 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011022 TM-ABC transporter signature motif; other site 573413011023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011025 TM-ABC transporter signature motif; other site 573413011026 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413011027 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413011028 Walker A/P-loop; other site 573413011029 ATP binding site [chemical binding]; other site 573413011030 Q-loop/lid; other site 573413011031 ABC transporter signature motif; other site 573413011032 Walker B; other site 573413011033 D-loop; other site 573413011034 H-loop/switch region; other site 573413011035 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413011036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413011037 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 573413011038 putative ligand binding site [chemical binding]; other site 573413011039 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 573413011040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413011041 active site 573413011042 phosphorylation site [posttranslational modification] 573413011043 intermolecular recognition site; other site 573413011044 dimerization interface [polypeptide binding]; other site 573413011045 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413011046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413011047 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 573413011048 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413011049 dimerization interface [polypeptide binding]; other site 573413011050 Histidine kinase; Region: His_kinase; pfam06580 573413011051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011052 ATP binding site [chemical binding]; other site 573413011053 Mg2+ binding site [ion binding]; other site 573413011054 G-X-G motif; other site 573413011055 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 573413011056 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 573413011057 putative ligand binding site [chemical binding]; other site 573413011058 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 573413011059 putative active site [active] 573413011060 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413011061 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413011062 active site 573413011063 NAD binding site [chemical binding]; other site 573413011064 metal binding site [ion binding]; metal-binding site 573413011065 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413011066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011067 DNA binding site [nucleotide binding] 573413011068 domain linker motif; other site 573413011069 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413011070 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413011071 ligand binding site [chemical binding]; other site 573413011072 ribulokinase; Provisional; Region: PRK04123 573413011073 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 573413011074 N- and C-terminal domain interface [polypeptide binding]; other site 573413011075 active site 573413011076 MgATP binding site [chemical binding]; other site 573413011077 catalytic site [active] 573413011078 metal binding site [ion binding]; metal-binding site 573413011079 carbohydrate binding site [chemical binding]; other site 573413011080 homodimer interface [polypeptide binding]; other site 573413011081 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573413011082 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 573413011083 intersubunit interface [polypeptide binding]; other site 573413011084 active site 573413011085 Zn2+ binding site [ion binding]; other site 573413011086 L-arabinose isomerase; Provisional; Region: PRK02929 573413011087 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 573413011088 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 573413011089 trimer interface [polypeptide binding]; other site 573413011090 putative substrate binding site [chemical binding]; other site 573413011091 putative metal binding site [ion binding]; other site 573413011092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413011093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413011094 ligand binding site [chemical binding]; other site 573413011095 flexible hinge region; other site 573413011096 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 573413011097 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413011098 4Fe-4S binding domain; Region: Fer4; pfam00037 573413011099 4Fe-4S binding domain; Region: Fer4; pfam00037 573413011100 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413011101 Putative Fe-S cluster; Region: FeS; cl17515 573413011102 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413011103 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413011104 dimer interface [polypeptide binding]; other site 573413011105 putative CheW interface [polypeptide binding]; other site 573413011106 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573413011107 Ligand Binding Site [chemical binding]; other site 573413011108 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 573413011109 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573413011110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 573413011111 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 573413011112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 573413011113 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 573413011114 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413011115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011117 DNA binding site [nucleotide binding] 573413011118 domain linker motif; other site 573413011119 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413011120 dimerization interface [polypeptide binding]; other site 573413011121 ligand binding site [chemical binding]; other site 573413011122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413011123 Outer membrane efflux protein; Region: OEP; pfam02321 573413011124 Outer membrane efflux protein; Region: OEP; pfam02321 573413011125 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 573413011126 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 573413011127 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413011128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573413011129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573413011130 Walker A/P-loop; other site 573413011131 ATP binding site [chemical binding]; other site 573413011132 Q-loop/lid; other site 573413011133 ABC transporter signature motif; other site 573413011134 Walker B; other site 573413011135 D-loop; other site 573413011136 H-loop/switch region; other site 573413011137 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573413011138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011139 Walker A/P-loop; other site 573413011140 ATP binding site [chemical binding]; other site 573413011141 Q-loop/lid; other site 573413011142 ABC transporter signature motif; other site 573413011143 Walker B; other site 573413011144 D-loop; other site 573413011145 H-loop/switch region; other site 573413011146 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573413011147 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573413011148 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 573413011149 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573413011150 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573413011151 putative transcriptional regulator; Provisional; Region: tfx; cl17550 573413011152 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573413011153 AAA domain; Region: AAA_33; pfam13671 573413011154 AAA domain; Region: AAA_17; pfam13207 573413011155 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573413011156 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 573413011157 intersubunit interface [polypeptide binding]; other site 573413011158 active site 573413011159 zinc binding site [ion binding]; other site 573413011160 Na+ binding site [ion binding]; other site 573413011161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413011162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413011163 nucleotide binding site [chemical binding]; other site 573413011164 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413011165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011166 dimer interface [polypeptide binding]; other site 573413011167 conserved gate region; other site 573413011168 putative PBP binding loops; other site 573413011169 ABC-ATPase subunit interface; other site 573413011170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011171 dimer interface [polypeptide binding]; other site 573413011172 conserved gate region; other site 573413011173 putative PBP binding loops; other site 573413011174 ABC-ATPase subunit interface; other site 573413011175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011177 DNA binding site [nucleotide binding] 573413011178 domain linker motif; other site 573413011179 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413011180 ligand binding site [chemical binding]; other site 573413011181 dimerization interface [polypeptide binding]; other site 573413011182 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413011183 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 573413011184 NAD(P) binding site [chemical binding]; other site 573413011185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573413011186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413011187 NAD(P) binding site [chemical binding]; other site 573413011188 active site 573413011189 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011190 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011191 TM-ABC transporter signature motif; other site 573413011192 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413011193 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413011194 Walker A/P-loop; other site 573413011195 ATP binding site [chemical binding]; other site 573413011196 Q-loop/lid; other site 573413011197 ABC transporter signature motif; other site 573413011198 Walker B; other site 573413011199 D-loop; other site 573413011200 H-loop/switch region; other site 573413011201 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413011202 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 573413011203 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413011204 putative ligand binding site [chemical binding]; other site 573413011205 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 573413011206 Creatinine amidohydrolase; Region: Creatininase; cl00618 573413011207 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413011208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413011209 DNA-binding site [nucleotide binding]; DNA binding site 573413011210 FCD domain; Region: FCD; pfam07729 573413011211 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 573413011212 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 573413011213 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 573413011214 active site 573413011215 catalytic site [active] 573413011216 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 573413011217 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 573413011218 camphor resistance protein CrcB; Provisional; Region: PRK14212 573413011219 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 573413011220 FOG: CBS domain [General function prediction only]; Region: COG0517 573413011221 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413011222 FOG: CBS domain [General function prediction only]; Region: COG0517 573413011223 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573413011224 FOG: CBS domain [General function prediction only]; Region: COG0517 573413011225 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573413011226 pyrrolysine biosynthesis radical SAM protein; Region: pyrrolys_PylB; TIGR03910 573413011227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413011228 FeS/SAM binding site; other site 573413011229 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413011230 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 573413011231 putative ligand binding residues [chemical binding]; other site 573413011232 Uncharacterized conserved protein [Function unknown]; Region: COG2014 573413011233 Domain of unknown function (DUF364); Region: DUF364; pfam04016 573413011234 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573413011235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011236 dimer interface [polypeptide binding]; other site 573413011237 conserved gate region; other site 573413011238 putative PBP binding loops; other site 573413011239 ABC-ATPase subunit interface; other site 573413011240 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 573413011241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413011242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011243 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 573413011244 Walker A/P-loop; other site 573413011245 ATP binding site [chemical binding]; other site 573413011246 Q-loop/lid; other site 573413011247 ABC transporter signature motif; other site 573413011248 Walker B; other site 573413011249 D-loop; other site 573413011250 H-loop/switch region; other site 573413011251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573413011252 MarR family; Region: MarR; pfam01047 573413011253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011254 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011255 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011256 Walker A/P-loop; other site 573413011257 ATP binding site [chemical binding]; other site 573413011258 Q-loop/lid; other site 573413011259 ABC transporter signature motif; other site 573413011260 Walker B; other site 573413011261 D-loop; other site 573413011262 H-loop/switch region; other site 573413011263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011265 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573413011266 Walker A/P-loop; other site 573413011267 ATP binding site [chemical binding]; other site 573413011268 Q-loop/lid; other site 573413011269 ABC transporter signature motif; other site 573413011270 Walker B; other site 573413011271 D-loop; other site 573413011272 H-loop/switch region; other site 573413011273 PAS domain; Region: PAS_8; pfam13188 573413011274 PAS fold; Region: PAS_4; pfam08448 573413011275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011276 putative active site [active] 573413011277 heme pocket [chemical binding]; other site 573413011278 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413011279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413011280 DNA binding residues [nucleotide binding] 573413011281 Cache domain; Region: Cache_1; pfam02743 573413011282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413011283 dimerization interface [polypeptide binding]; other site 573413011284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413011285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413011286 dimer interface [polypeptide binding]; other site 573413011287 putative CheW interface [polypeptide binding]; other site 573413011288 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 573413011289 glycerate kinase; Region: TIGR00045 573413011290 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 573413011291 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 573413011292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573413011293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413011294 dimerization interface [polypeptide binding]; other site 573413011295 putative DNA binding site [nucleotide binding]; other site 573413011296 putative Zn2+ binding site [ion binding]; other site 573413011297 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 573413011298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573413011299 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573413011300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413011301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413011302 metal binding site [ion binding]; metal-binding site 573413011303 active site 573413011304 I-site; other site 573413011305 hypothetical protein; Reviewed; Region: PRK00024 573413011306 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 573413011307 MPN+ (JAMM) motif; other site 573413011308 Zinc-binding site [ion binding]; other site 573413011309 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573413011310 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573413011311 G1 box; other site 573413011312 GTP/Mg2+ binding site [chemical binding]; other site 573413011313 Switch I region; other site 573413011314 G2 box; other site 573413011315 G3 box; other site 573413011316 Switch II region; other site 573413011317 G4 box; other site 573413011318 G5 box; other site 573413011319 Nucleoside recognition; Region: Gate; pfam07670 573413011320 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573413011321 FeoA domain; Region: FeoA; cl00838 573413011322 MarR family; Region: MarR_2; cl17246 573413011323 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413011324 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413011325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011328 Walker A/P-loop; other site 573413011329 ATP binding site [chemical binding]; other site 573413011330 Q-loop/lid; other site 573413011331 ABC transporter signature motif; other site 573413011332 Walker B; other site 573413011333 D-loop; other site 573413011334 H-loop/switch region; other site 573413011335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011338 Walker A/P-loop; other site 573413011339 ATP binding site [chemical binding]; other site 573413011340 Q-loop/lid; other site 573413011341 ABC transporter signature motif; other site 573413011342 Walker B; other site 573413011343 D-loop; other site 573413011344 H-loop/switch region; other site 573413011345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413011346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413011347 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573413011348 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413011349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413011350 DNA binding residues [nucleotide binding] 573413011351 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573413011352 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 573413011353 PHP-associated; Region: PHP_C; pfam13263 573413011354 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 573413011355 Part of AAA domain; Region: AAA_19; pfam13245 573413011356 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573413011357 Family description; Region: UvrD_C_2; pfam13538 573413011358 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 573413011359 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573413011360 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 573413011361 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 573413011362 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 573413011363 homopentamer interface [polypeptide binding]; other site 573413011364 active site 573413011365 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 573413011366 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 573413011367 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 573413011368 Lumazine binding domain; Region: Lum_binding; pfam00677 573413011369 Lumazine binding domain; Region: Lum_binding; pfam00677 573413011370 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 573413011371 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 573413011372 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573413011373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011374 Walker A/P-loop; other site 573413011375 ATP binding site [chemical binding]; other site 573413011376 Q-loop/lid; other site 573413011377 ABC transporter signature motif; other site 573413011378 Walker B; other site 573413011379 D-loop; other site 573413011380 H-loop/switch region; other site 573413011381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573413011382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413011383 putative DNA binding site [nucleotide binding]; other site 573413011384 putative Zn2+ binding site [ion binding]; other site 573413011385 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573413011386 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573413011387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573413011388 RNA binding surface [nucleotide binding]; other site 573413011389 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 573413011390 catalytic residue [active] 573413011391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011394 Walker A/P-loop; other site 573413011395 ATP binding site [chemical binding]; other site 573413011396 Q-loop/lid; other site 573413011397 ABC transporter signature motif; other site 573413011398 Walker B; other site 573413011399 D-loop; other site 573413011400 H-loop/switch region; other site 573413011401 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413011402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413011403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011404 Walker A/P-loop; other site 573413011405 ATP binding site [chemical binding]; other site 573413011406 Q-loop/lid; other site 573413011407 ABC transporter signature motif; other site 573413011408 Walker B; other site 573413011409 D-loop; other site 573413011410 H-loop/switch region; other site 573413011411 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573413011412 4Fe-4S binding domain; Region: Fer4_6; pfam12837 573413011413 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 573413011414 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573413011415 NAD binding site [chemical binding]; other site 573413011416 substrate binding site [chemical binding]; other site 573413011417 putative active site [active] 573413011418 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 573413011419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413011420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573413011421 dimerization interface [polypeptide binding]; other site 573413011422 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 573413011423 Pyruvate formate lyase 1; Region: PFL1; cd01678 573413011424 coenzyme A binding site [chemical binding]; other site 573413011425 active site 573413011426 catalytic residues [active] 573413011427 glycine loop; other site 573413011428 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 573413011429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413011430 FeS/SAM binding site; other site 573413011431 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 573413011432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413011433 active site 573413011434 motif I; other site 573413011435 motif II; other site 573413011436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413011437 DctM-like transporters; Region: DctM; pfam06808 573413011438 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 573413011439 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 573413011440 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413011441 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573413011442 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 573413011443 metal-binding site [ion binding] 573413011444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 573413011445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413011446 S-adenosylmethionine binding site [chemical binding]; other site 573413011447 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 573413011448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413011449 S-adenosylmethionine binding site [chemical binding]; other site 573413011450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573413011451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413011452 S-adenosylmethionine binding site [chemical binding]; other site 573413011453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011454 dimer interface [polypeptide binding]; other site 573413011455 conserved gate region; other site 573413011456 putative PBP binding loops; other site 573413011457 ABC-ATPase subunit interface; other site 573413011458 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413011459 hypothetical protein; Provisional; Region: PRK11622 573413011460 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413011461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011462 Walker A/P-loop; other site 573413011463 ATP binding site [chemical binding]; other site 573413011464 Q-loop/lid; other site 573413011465 ABC transporter signature motif; other site 573413011466 Walker B; other site 573413011467 D-loop; other site 573413011468 H-loop/switch region; other site 573413011469 TOBE domain; Region: TOBE_2; pfam08402 573413011470 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413011471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011472 dimer interface [polypeptide binding]; other site 573413011473 conserved gate region; other site 573413011474 putative PBP binding loops; other site 573413011475 ABC-ATPase subunit interface; other site 573413011476 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573413011477 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 573413011478 active site 573413011479 catalytic site [active] 573413011480 metal binding site [ion binding]; metal-binding site 573413011481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011483 DNA binding site [nucleotide binding] 573413011484 domain linker motif; other site 573413011485 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413011486 dimerization interface [polypeptide binding]; other site 573413011487 ligand binding site [chemical binding]; other site 573413011488 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573413011489 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573413011490 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573413011491 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573413011492 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573413011493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573413011494 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 573413011495 IMP binding site; other site 573413011496 dimer interface [polypeptide binding]; other site 573413011497 partial ornithine binding site; other site 573413011498 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573413011499 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 573413011500 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573413011501 catalytic site [active] 573413011502 subunit interface [polypeptide binding]; other site 573413011503 Response regulator receiver domain; Region: Response_reg; pfam00072 573413011504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413011505 active site 573413011506 phosphorylation site [posttranslational modification] 573413011507 intermolecular recognition site; other site 573413011508 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011509 putative active site [active] 573413011510 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413011511 heme pocket [chemical binding]; other site 573413011512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011513 putative active site [active] 573413011514 heme pocket [chemical binding]; other site 573413011515 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011516 PAS fold; Region: PAS_3; pfam08447 573413011517 putative active site [active] 573413011518 heme pocket [chemical binding]; other site 573413011519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413011520 Histidine kinase; Region: HisKA_2; pfam07568 573413011521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011522 ATP binding site [chemical binding]; other site 573413011523 Mg2+ binding site [ion binding]; other site 573413011524 G-X-G motif; other site 573413011525 PAS fold; Region: PAS_4; pfam08448 573413011526 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413011527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011528 putative active site [active] 573413011529 heme pocket [chemical binding]; other site 573413011530 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413011531 dimer interface [polypeptide binding]; other site 573413011532 phosphorylation site [posttranslational modification] 573413011533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011534 ATP binding site [chemical binding]; other site 573413011535 Mg2+ binding site [ion binding]; other site 573413011536 G-X-G motif; other site 573413011537 Response regulator receiver domain; Region: Response_reg; pfam00072 573413011538 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413011539 active site 573413011540 phosphorylation site [posttranslational modification] 573413011541 intermolecular recognition site; other site 573413011542 dimerization interface [polypeptide binding]; other site 573413011543 glycerol kinase; Provisional; Region: glpK; PRK00047 573413011544 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 573413011545 N- and C-terminal domain interface [polypeptide binding]; other site 573413011546 active site 573413011547 MgATP binding site [chemical binding]; other site 573413011548 catalytic site [active] 573413011549 metal binding site [ion binding]; metal-binding site 573413011550 glycerol binding site [chemical binding]; other site 573413011551 homotetramer interface [polypeptide binding]; other site 573413011552 homodimer interface [polypeptide binding]; other site 573413011553 FBP binding site [chemical binding]; other site 573413011554 protein IIAGlc interface [polypeptide binding]; other site 573413011555 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 573413011556 amphipathic channel; other site 573413011557 Asn-Pro-Ala signature motifs; other site 573413011558 Predicted dehydrogenase [General function prediction only]; Region: COG0579 573413011559 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573413011560 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 573413011561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 573413011562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573413011563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573413011564 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 573413011565 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573413011566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573413011567 DNA binding residues [nucleotide binding] 573413011568 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573413011569 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 573413011570 hydrophobic ligand binding site; other site 573413011571 RibD C-terminal domain; Region: RibD_C; cl17279 573413011572 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 573413011573 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 573413011574 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573413011575 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413011576 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413011577 catalytic residue [active] 573413011578 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 573413011579 CPxP motif; other site 573413011580 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 573413011581 Predicted membrane protein [Function unknown]; Region: COG1971 573413011582 Domain of unknown function DUF; Region: DUF204; pfam02659 573413011583 Domain of unknown function DUF; Region: DUF204; pfam02659 573413011584 HTH domain; Region: HTH_11; pfam08279 573413011585 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 573413011586 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 573413011587 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 573413011588 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 573413011589 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 573413011590 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573413011591 dimerization domain swap beta strand [polypeptide binding]; other site 573413011592 regulatory protein interface [polypeptide binding]; other site 573413011593 active site 573413011594 regulatory phosphorylation site [posttranslational modification]; other site 573413011595 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413011596 substrate binding site [chemical binding]; other site 573413011597 ATP binding site [chemical binding]; other site 573413011598 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413011599 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 573413011600 putative NAD(P) binding site [chemical binding]; other site 573413011601 catalytic Zn binding site [ion binding]; other site 573413011602 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413011603 active site 573413011604 phosphorylation site [posttranslational modification] 573413011605 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 573413011606 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 573413011607 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 573413011608 active site 573413011609 P-loop; other site 573413011610 phosphorylation site [posttranslational modification] 573413011611 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 573413011612 active site 573413011613 catalytic residues [active] 573413011614 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 573413011615 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413011616 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573413011617 active site 573413011618 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 573413011619 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 573413011620 active site 573413011621 ADP/pyrophosphate binding site [chemical binding]; other site 573413011622 allosteric effector site; other site 573413011623 dimerization interface [polypeptide binding]; other site 573413011624 fructose-1,6-bisphosphate binding site; other site 573413011625 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 573413011626 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 573413011627 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573413011628 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573413011629 active site 573413011630 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 573413011631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011632 PAS fold; Region: PAS_3; pfam08447 573413011633 putative active site [active] 573413011634 heme pocket [chemical binding]; other site 573413011635 PAS domain S-box; Region: sensory_box; TIGR00229 573413011636 PAS domain; Region: PAS_8; pfam13188 573413011637 putative active site [active] 573413011638 heme pocket [chemical binding]; other site 573413011639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413011640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413011641 metal binding site [ion binding]; metal-binding site 573413011642 active site 573413011643 I-site; other site 573413011644 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413011645 catalytic residues [active] 573413011646 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 573413011647 putative active site [active] 573413011648 Zn binding site [ion binding]; other site 573413011649 RNHCP domain; Region: RNHCP; pfam12647 573413011650 Predicted GTPases [General function prediction only]; Region: COG1162 573413011651 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 573413011652 GTPase/Zn-binding domain interface [polypeptide binding]; other site 573413011653 GTP/Mg2+ binding site [chemical binding]; other site 573413011654 G4 box; other site 573413011655 G5 box; other site 573413011656 G1 box; other site 573413011657 Switch I region; other site 573413011658 G2 box; other site 573413011659 G3 box; other site 573413011660 Switch II region; other site 573413011661 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 573413011662 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 573413011663 putative active site [active] 573413011664 catalytic triad [active] 573413011665 putative dimer interface [polypeptide binding]; other site 573413011666 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 573413011667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413011668 motif II; other site 573413011669 Cupin domain; Region: Cupin_2; pfam07883 573413011670 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 573413011671 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413011672 nucleotide binding site [chemical binding]; other site 573413011673 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 573413011674 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 573413011675 ligand binding site [chemical binding]; other site 573413011676 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011677 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011678 TM-ABC transporter signature motif; other site 573413011679 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011680 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011681 TM-ABC transporter signature motif; other site 573413011682 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413011683 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413011684 Walker A/P-loop; other site 573413011685 ATP binding site [chemical binding]; other site 573413011686 Q-loop/lid; other site 573413011687 ABC transporter signature motif; other site 573413011688 Walker B; other site 573413011689 D-loop; other site 573413011690 H-loop/switch region; other site 573413011691 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413011692 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 573413011693 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 573413011694 putative active site; other site 573413011695 catalytic residue [active] 573413011696 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 573413011697 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 573413011698 Membrane transport protein; Region: Mem_trans; cl09117 573413011699 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 573413011700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413011701 NAD(P) binding site [chemical binding]; other site 573413011702 active site 573413011703 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413011704 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413011705 substrate binding site [chemical binding]; other site 573413011706 ATP binding site [chemical binding]; other site 573413011707 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 573413011708 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 573413011709 active site 573413011710 intersubunit interface [polypeptide binding]; other site 573413011711 catalytic residue [active] 573413011712 Uncharacterized conserved protein [Function unknown]; Region: COG1912 573413011713 Uncharacterized conserved protein [Function unknown]; Region: COG1912 573413011714 hypothetical protein; Provisional; Region: PRK13661 573413011715 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573413011716 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413011717 Walker A/P-loop; other site 573413011718 ATP binding site [chemical binding]; other site 573413011719 Q-loop/lid; other site 573413011720 ABC transporter signature motif; other site 573413011721 Walker B; other site 573413011722 D-loop; other site 573413011723 H-loop/switch region; other site 573413011724 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 573413011725 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413011726 Walker A/P-loop; other site 573413011727 ATP binding site [chemical binding]; other site 573413011728 Q-loop/lid; other site 573413011729 ABC transporter signature motif; other site 573413011730 Walker B; other site 573413011731 D-loop; other site 573413011732 H-loop/switch region; other site 573413011733 HRDC domain; Region: HRDC; cl02578 573413011734 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413011735 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573413011736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413011737 Walker A/P-loop; other site 573413011738 ATP binding site [chemical binding]; other site 573413011739 Q-loop/lid; other site 573413011740 ABC transporter signature motif; other site 573413011741 Walker B; other site 573413011742 D-loop; other site 573413011743 H-loop/switch region; other site 573413011744 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573413011745 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573413011746 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573413011747 MarR family; Region: MarR_2; pfam12802 573413011748 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573413011749 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 573413011750 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 573413011751 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 573413011752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413011753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011754 dimer interface [polypeptide binding]; other site 573413011755 conserved gate region; other site 573413011756 putative PBP binding loops; other site 573413011757 ABC-ATPase subunit interface; other site 573413011758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011759 dimer interface [polypeptide binding]; other site 573413011760 conserved gate region; other site 573413011761 putative PBP binding loops; other site 573413011762 ABC-ATPase subunit interface; other site 573413011763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413011764 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413011765 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413011766 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413011767 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413011768 putative active site [active] 573413011769 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413011770 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 573413011771 substrate binding site [chemical binding]; other site 573413011772 ATP binding site [chemical binding]; other site 573413011773 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573413011774 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 573413011775 putative NAD(P) binding site [chemical binding]; other site 573413011776 catalytic Zn binding site [ion binding]; other site 573413011777 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413011778 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413011779 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413011780 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413011781 L-aspartate oxidase; Provisional; Region: PRK06175 573413011782 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 573413011783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413011784 active site 573413011785 phosphorylation site [posttranslational modification] 573413011786 intermolecular recognition site; other site 573413011787 dimerization interface [polypeptide binding]; other site 573413011788 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 573413011789 PAS domain; Region: PAS; smart00091 573413011790 putative active site [active] 573413011791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011792 ATP binding site [chemical binding]; other site 573413011793 Mg2+ binding site [ion binding]; other site 573413011794 G-X-G motif; other site 573413011795 FMN-binding domain; Region: FMN_bind; pfam04205 573413011796 L-aspartate oxidase; Provisional; Region: PRK06175 573413011797 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413011798 PemK-like protein; Region: PemK; pfam02452 573413011799 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573413011800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413011801 non-specific DNA binding site [nucleotide binding]; other site 573413011802 salt bridge; other site 573413011803 sequence-specific DNA binding site [nucleotide binding]; other site 573413011804 Domain of unknown function (DUF955); Region: DUF955; cl01076 573413011805 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573413011806 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 573413011807 intersubunit interface [polypeptide binding]; other site 573413011808 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 573413011809 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 573413011810 dimer interface [polypeptide binding]; other site 573413011811 putative functional site; other site 573413011812 putative MPT binding site; other site 573413011813 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 573413011814 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413011815 ABC-ATPase subunit interface; other site 573413011816 dimer interface [polypeptide binding]; other site 573413011817 putative PBP binding regions; other site 573413011818 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413011819 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413011820 Walker A/P-loop; other site 573413011821 ATP binding site [chemical binding]; other site 573413011822 Q-loop/lid; other site 573413011823 ABC transporter signature motif; other site 573413011824 Walker B; other site 573413011825 D-loop; other site 573413011826 H-loop/switch region; other site 573413011827 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413011828 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413011829 ligand binding site [chemical binding]; other site 573413011830 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413011831 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413011832 Walker A/P-loop; other site 573413011833 ATP binding site [chemical binding]; other site 573413011834 Q-loop/lid; other site 573413011835 ABC transporter signature motif; other site 573413011836 Walker B; other site 573413011837 D-loop; other site 573413011838 H-loop/switch region; other site 573413011839 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413011840 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011841 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011842 TM-ABC transporter signature motif; other site 573413011843 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 573413011844 active site 573413011845 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 573413011846 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 573413011847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011849 DNA binding site [nucleotide binding] 573413011850 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413011851 ligand binding site [chemical binding]; other site 573413011852 dimerization interface [polypeptide binding]; other site 573413011853 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413011854 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413011855 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 573413011856 dimerization interface [polypeptide binding]; other site 573413011857 putative active cleft [active] 573413011858 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413011860 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413011861 TM-ABC transporter signature motif; other site 573413011862 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413011863 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573413011864 Walker A/P-loop; other site 573413011865 ATP binding site [chemical binding]; other site 573413011866 Q-loop/lid; other site 573413011867 ABC transporter signature motif; other site 573413011868 Walker B; other site 573413011869 D-loop; other site 573413011870 H-loop/switch region; other site 573413011871 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413011872 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 573413011873 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413011874 putative ligand binding site [chemical binding]; other site 573413011875 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 573413011876 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573413011877 intersubunit interface [polypeptide binding]; other site 573413011878 active site 573413011879 catalytic residue [active] 573413011880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413011881 DNA-binding site [nucleotide binding]; DNA binding site 573413011882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011883 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413011884 ligand binding site [chemical binding]; other site 573413011885 Class I aldolases; Region: Aldolase_Class_I; cl17187 573413011886 catalytic residue [active] 573413011887 hypothetical protein; Provisional; Region: PRK02947 573413011888 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413011889 putative active site [active] 573413011890 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573413011891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413011892 nucleotide binding site [chemical binding]; other site 573413011893 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 573413011894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573413011895 ATP binding site [chemical binding]; other site 573413011896 putative Mg++ binding site [ion binding]; other site 573413011897 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413011898 nucleotide binding region [chemical binding]; other site 573413011899 ATP-binding site [chemical binding]; other site 573413011900 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413011901 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413011902 DNA binding site [nucleotide binding] 573413011903 domain linker motif; other site 573413011904 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 573413011905 dimerization interface [polypeptide binding]; other site 573413011906 ligand binding site [chemical binding]; other site 573413011907 sodium binding site [ion binding]; other site 573413011908 putative hydrolase; Provisional; Region: PRK02113 573413011909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 573413011910 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413011911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011912 dimer interface [polypeptide binding]; other site 573413011913 conserved gate region; other site 573413011914 putative PBP binding loops; other site 573413011915 ABC-ATPase subunit interface; other site 573413011916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011917 dimer interface [polypeptide binding]; other site 573413011918 conserved gate region; other site 573413011919 putative PBP binding loops; other site 573413011920 ABC-ATPase subunit interface; other site 573413011921 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413011922 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 573413011923 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573413011924 active site 573413011925 metal binding site [ion binding]; metal-binding site 573413011926 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 573413011927 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 573413011928 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 573413011929 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 573413011930 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 573413011931 beta-phosphoglucomutase; Region: bPGM; TIGR01990 573413011932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413011933 motif II; other site 573413011934 PAS domain S-box; Region: sensory_box; TIGR00229 573413011935 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413011936 putative active site [active] 573413011937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413011938 Histidine kinase; Region: HisKA_2; pfam07568 573413011939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011940 ATP binding site [chemical binding]; other site 573413011941 Mg2+ binding site [ion binding]; other site 573413011942 G-X-G motif; other site 573413011943 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413011944 xylulokinase; Region: PLN02669 573413011945 nucleotide binding site [chemical binding]; other site 573413011946 uracil transporter; Provisional; Region: PRK10720 573413011947 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 573413011948 glyoxylate reductase; Reviewed; Region: PRK13243 573413011949 dimerization interface [polypeptide binding]; other site 573413011950 ligand binding site [chemical binding]; other site 573413011951 NADP binding site [chemical binding]; other site 573413011952 catalytic site [active] 573413011953 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 573413011954 CoA binding domain; Region: CoA_binding; pfam02629 573413011955 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413011956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413011957 active site 573413011958 phosphorylation site [posttranslational modification] 573413011959 intermolecular recognition site; other site 573413011960 dimerization interface [polypeptide binding]; other site 573413011961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413011962 DNA binding residues [nucleotide binding] 573413011963 dimerization interface [polypeptide binding]; other site 573413011964 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 573413011965 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 573413011966 active site 573413011967 dimerization interface [polypeptide binding]; other site 573413011968 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413011969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011970 dimer interface [polypeptide binding]; other site 573413011971 conserved gate region; other site 573413011972 putative PBP binding loops; other site 573413011973 ABC-ATPase subunit interface; other site 573413011974 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 573413011975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413011976 dimer interface [polypeptide binding]; other site 573413011977 conserved gate region; other site 573413011978 putative PBP binding loops; other site 573413011979 ABC-ATPase subunit interface; other site 573413011980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413011981 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413011982 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573413011983 putative transposase OrfB; Reviewed; Region: PHA02517 573413011984 HTH-like domain; Region: HTH_21; pfam13276 573413011985 Integrase core domain; Region: rve; pfam00665 573413011986 Integrase core domain; Region: rve_3; cl15866 573413011987 Transposase; Region: HTH_Tnp_1; cl17663 573413011988 DRTGG domain; Region: DRTGG; pfam07085 573413011989 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 573413011990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413011991 ATP binding site [chemical binding]; other site 573413011992 G-X-G motif; other site 573413011993 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413011994 4Fe-4S binding domain; Region: Fer4; pfam00037 573413011995 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413011996 Putative Fe-S cluster; Region: FeS; cl17515 573413011997 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 573413011998 catalytic core [active] 573413011999 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413012000 putative efflux protein, MATE family; Region: matE; TIGR00797 573413012001 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 573413012002 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 573413012003 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573413012004 Peptidase M16C associated; Region: M16C_assoc; pfam08367 573413012005 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 573413012006 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 573413012007 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 573413012008 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 573413012009 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 573413012010 RNA binding site [nucleotide binding]; other site 573413012011 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573413012012 Na binding site [ion binding]; other site 573413012013 Protein of unknown function (DUF917); Region: DUF917; pfam06032 573413012014 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 573413012015 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573413012016 Bacterial transcriptional regulator; Region: IclR; pfam01614 573413012017 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573413012018 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) [Translation, ribosomal structure and biogenesis]; Region: COG2269 573413012019 motif 1; other site 573413012020 dimer interface [polypeptide binding]; other site 573413012021 active site 573413012022 motif 2; other site 573413012023 motif 3; other site 573413012024 elongation factor P; Validated; Region: PRK00529 573413012025 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573413012026 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573413012027 RNA binding site [nucleotide binding]; other site 573413012028 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573413012029 RNA binding site [nucleotide binding]; other site 573413012030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413012031 S-adenosylmethionine binding site [chemical binding]; other site 573413012032 Transcriptional regulator; Region: Rrf2; cl17282 573413012033 Rrf2 family protein; Region: rrf2_super; TIGR00738 573413012034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573413012035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573413012036 PAS domain; Region: PAS; smart00091 573413012037 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413012038 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 573413012039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413012040 putative active site [active] 573413012041 heme pocket [chemical binding]; other site 573413012042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413012043 Zn2+ binding site [ion binding]; other site 573413012044 Mg2+ binding site [ion binding]; other site 573413012045 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413012046 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413012047 ligand binding site [chemical binding]; other site 573413012048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413012049 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573413012050 FeS/SAM binding site; other site 573413012051 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 573413012052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413012053 Sporulation related domain; Region: SPOR; pfam05036 573413012054 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 573413012055 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573413012056 CoA-binding site [chemical binding]; other site 573413012057 ATP-binding [chemical binding]; other site 573413012058 DNA polymerase I; Provisional; Region: PRK05755 573413012059 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573413012060 active site 573413012061 metal binding site 1 [ion binding]; metal-binding site 573413012062 putative 5' ssDNA interaction site; other site 573413012063 metal binding site 3; metal-binding site 573413012064 metal binding site 2 [ion binding]; metal-binding site 573413012065 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573413012066 putative DNA binding site [nucleotide binding]; other site 573413012067 putative metal binding site [ion binding]; other site 573413012068 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 573413012069 active site 573413012070 catalytic site [active] 573413012071 substrate binding site [chemical binding]; other site 573413012072 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573413012073 active site 573413012074 DNA binding site [nucleotide binding] 573413012075 catalytic site [active] 573413012076 Flagellar protein FliS; Region: FliS; cl00654 573413012077 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573413012078 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573413012079 NodB motif; other site 573413012080 active site 573413012081 catalytic site [active] 573413012082 metal binding site [ion binding]; metal-binding site 573413012083 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 573413012084 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 573413012085 putative hydrolase; Provisional; Region: PRK02113 573413012086 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 573413012087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413012088 DNA-binding site [nucleotide binding]; DNA binding site 573413012089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413012090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413012091 homodimer interface [polypeptide binding]; other site 573413012092 catalytic residue [active] 573413012093 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 573413012094 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 573413012095 active site 573413012096 multimer interface [polypeptide binding]; other site 573413012097 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573413012098 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 573413012099 conserved cys residue [active] 573413012100 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 573413012101 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 573413012102 putative active site [active] 573413012103 PhoH-like protein; Region: PhoH; pfam02562 573413012104 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 573413012105 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413012106 catalytic loop [active] 573413012107 iron binding site [ion binding]; other site 573413012108 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 573413012109 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 573413012110 4Fe-4S binding domain; Region: Fer4; pfam00037 573413012111 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 573413012112 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 573413012113 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413012114 dimer interface [polypeptide binding]; other site 573413012115 [2Fe-2S] cluster binding site [ion binding]; other site 573413012116 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 573413012117 SLBB domain; Region: SLBB; pfam10531 573413012118 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 573413012119 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 573413012120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413012121 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 573413012122 dimer interface [polypeptide binding]; other site 573413012123 [2Fe-2S] cluster binding site [ion binding]; other site 573413012124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413012125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012126 ATP binding site [chemical binding]; other site 573413012127 Mg2+ binding site [ion binding]; other site 573413012128 G-X-G motif; other site 573413012129 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 573413012130 HIRAN domain; Region: HIRAN; pfam08797 573413012131 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 573413012132 putative dimer interface [polypeptide binding]; other site 573413012133 [2Fe-2S] cluster binding site [ion binding]; other site 573413012134 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 573413012135 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 573413012136 CoA binding domain; Region: CoA_binding; smart00881 573413012137 RmuC family; Region: RmuC; pfam02646 573413012138 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573413012139 putative catalytic site [active] 573413012140 putative metal binding site [ion binding]; other site 573413012141 putative phosphate binding site [ion binding]; other site 573413012142 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573413012143 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 573413012144 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573413012145 acyl-activating enzyme (AAE) consensus motif; other site 573413012146 acyl-activating enzyme (AAE) consensus motif; other site 573413012147 putative AMP binding site [chemical binding]; other site 573413012148 putative active site [active] 573413012149 putative CoA binding site [chemical binding]; other site 573413012150 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413012151 ATP-dependent Clp protease proteolytic subunit; Provisional; Region: PRK14512 573413012152 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573413012153 oligomer interface [polypeptide binding]; other site 573413012154 active site residues [active] 573413012155 GTPase Era; Reviewed; Region: era; PRK00089 573413012156 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573413012157 G1 box; other site 573413012158 GTP/Mg2+ binding site [chemical binding]; other site 573413012159 Switch I region; other site 573413012160 G2 box; other site 573413012161 Switch II region; other site 573413012162 G3 box; other site 573413012163 G4 box; other site 573413012164 G5 box; other site 573413012165 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 573413012166 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573413012167 active site 573413012168 nucleotide binding site [chemical binding]; other site 573413012169 HIGH motif; other site 573413012170 KMSKS motif; other site 573413012171 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 573413012172 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573413012173 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 573413012174 PhoU domain; Region: PhoU; pfam01895 573413012175 PhoU domain; Region: PhoU; pfam01895 573413012176 argininosuccinate lyase; Provisional; Region: PRK00855 573413012177 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573413012178 active sites [active] 573413012179 tetramer interface [polypeptide binding]; other site 573413012180 Uncharacterized conserved protein [Function unknown]; Region: COG2014 573413012181 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 573413012182 Domain of unknown function (DUF364); Region: DUF364; pfam04016 573413012183 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 573413012184 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 573413012185 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573413012186 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573413012187 Walker A/P-loop; other site 573413012188 ATP binding site [chemical binding]; other site 573413012189 Q-loop/lid; other site 573413012190 ABC transporter signature motif; other site 573413012191 Walker B; other site 573413012192 D-loop; other site 573413012193 H-loop/switch region; other site 573413012194 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573413012195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012196 dimer interface [polypeptide binding]; other site 573413012197 conserved gate region; other site 573413012198 putative PBP binding loops; other site 573413012199 ABC-ATPase subunit interface; other site 573413012200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573413012201 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 573413012202 nucleophilic elbow; other site 573413012203 catalytic triad; other site 573413012204 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573413012205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413012206 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 573413012207 DNA binding residues [nucleotide binding] 573413012208 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 573413012209 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573413012210 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 573413012211 DNA binding residues [nucleotide binding] 573413012212 drug binding residues [chemical binding]; other site 573413012213 dimer interface [polypeptide binding]; other site 573413012214 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 573413012215 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413012216 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573413012217 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573413012218 glutaminase active site [active] 573413012219 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573413012220 dimer interface [polypeptide binding]; other site 573413012221 active site 573413012222 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573413012223 dimer interface [polypeptide binding]; other site 573413012224 active site 573413012225 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413012226 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413012227 ligand binding site [chemical binding]; other site 573413012228 flexible hinge region; other site 573413012229 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573413012230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573413012231 catalytic residues [active] 573413012232 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573413012233 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573413012234 dimer interface [polypeptide binding]; other site 573413012235 ssDNA binding site [nucleotide binding]; other site 573413012236 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573413012237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413012238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413012239 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 573413012240 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 573413012241 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 573413012242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413012243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413012244 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 573413012245 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 573413012246 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 573413012247 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573413012248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413012249 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 573413012250 active site 573413012251 Cupin domain; Region: Cupin_2; cl17218 573413012252 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 573413012253 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573413012254 homodimer interface [polypeptide binding]; other site 573413012255 substrate-cofactor binding pocket; other site 573413012256 catalytic residue [active] 573413012257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 573413012258 TPR motif; other site 573413012259 binding surface 573413012260 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 573413012261 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 573413012262 glycogen binding site [chemical binding]; other site 573413012263 Predicted amidohydrolase [General function prediction only]; Region: COG0388 573413012264 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 573413012265 active site 573413012266 catalytic triad [active] 573413012267 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413012268 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 573413012269 ligand binding site [chemical binding]; other site 573413012270 NAD binding site [chemical binding]; other site 573413012271 catalytic site [active] 573413012272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413012273 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 573413012274 active site 573413012275 motif I; other site 573413012276 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 573413012277 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413012278 Walker A/P-loop; other site 573413012279 ATP binding site [chemical binding]; other site 573413012280 Q-loop/lid; other site 573413012281 ABC transporter signature motif; other site 573413012282 Walker B; other site 573413012283 D-loop; other site 573413012284 H-loop/switch region; other site 573413012285 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413012286 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 573413012287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413012288 Walker A/P-loop; other site 573413012289 ATP binding site [chemical binding]; other site 573413012290 Q-loop/lid; other site 573413012291 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 573413012292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573413012293 ABC transporter signature motif; other site 573413012294 Walker B; other site 573413012295 D-loop; other site 573413012296 H-loop/switch region; other site 573413012297 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 573413012298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573413012299 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573413012300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012301 dimer interface [polypeptide binding]; other site 573413012302 conserved gate region; other site 573413012303 ABC-ATPase subunit interface; other site 573413012304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573413012305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012306 dimer interface [polypeptide binding]; other site 573413012307 conserved gate region; other site 573413012308 putative PBP binding loops; other site 573413012309 ABC-ATPase subunit interface; other site 573413012310 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573413012311 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 573413012312 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 573413012313 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573413012314 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573413012315 motif 1; other site 573413012316 dimer interface [polypeptide binding]; other site 573413012317 active site 573413012318 motif 2; other site 573413012319 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573413012320 putative deacylase active site [active] 573413012321 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573413012322 active site 573413012323 motif 3; other site 573413012324 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573413012325 anticodon binding site; other site 573413012326 enolase; Provisional; Region: eno; PRK00077 573413012327 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573413012328 dimer interface [polypeptide binding]; other site 573413012329 metal binding site [ion binding]; metal-binding site 573413012330 substrate binding pocket [chemical binding]; other site 573413012331 Acylphosphatase; Region: Acylphosphatase; pfam00708 573413012332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012333 active site 573413012334 phosphorylation site [posttranslational modification] 573413012335 intermolecular recognition site; other site 573413012336 dimerization interface [polypeptide binding]; other site 573413012337 Helix-turn-helix domain; Region: HTH_17; pfam12728 573413012338 Response regulator receiver domain; Region: Response_reg; pfam00072 573413012339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012340 active site 573413012341 phosphorylation site [posttranslational modification] 573413012342 intermolecular recognition site; other site 573413012343 dimerization interface [polypeptide binding]; other site 573413012344 recombination regulator RecX; Reviewed; Region: recX; PRK00117 573413012345 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573413012346 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573413012347 23S rRNA interface [nucleotide binding]; other site 573413012348 L3 interface [polypeptide binding]; other site 573413012349 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 573413012350 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413012351 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 573413012352 Part of AAA domain; Region: AAA_19; pfam13245 573413012353 Family description; Region: UvrD_C_2; pfam13538 573413012354 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 573413012355 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573413012356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413012357 FeS/SAM binding site; other site 573413012358 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 573413012359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413012360 non-specific DNA binding site [nucleotide binding]; other site 573413012361 salt bridge; other site 573413012362 sequence-specific DNA binding site [nucleotide binding]; other site 573413012363 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 573413012364 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 573413012365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413012366 binding surface 573413012367 TPR motif; other site 573413012368 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413012369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413012370 TPR motif; other site 573413012371 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cd00162 573413012372 Zinc finger, C3HC4 type (RING finger); Region: zf-C3HC4_2; pfam13923 573413012373 cross-brace motif; other site 573413012374 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 573413012375 nucleotide binding site [chemical binding]; other site 573413012376 substrate binding site [chemical binding]; other site 573413012377 Radical SAM superfamily; Region: Radical_SAM; pfam04055 573413012378 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413012379 active site 573413012380 phosphorylation site [posttranslational modification] 573413012381 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 573413012382 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 573413012383 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 573413012384 hypothetical protein; Provisional; Region: PRK08378 573413012385 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 573413012386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413012387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 573413012388 active site 573413012389 phosphorylation site [posttranslational modification] 573413012390 intermolecular recognition site; other site 573413012391 PAS domain S-box; Region: sensory_box; TIGR00229 573413012392 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413012393 Histidine kinase; Region: HisKA_2; pfam07568 573413012394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012395 ATP binding site [chemical binding]; other site 573413012396 Mg2+ binding site [ion binding]; other site 573413012397 G-X-G motif; other site 573413012398 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573413012399 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573413012400 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573413012401 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573413012402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413012403 Histidine kinase; Region: HisKA_2; pfam07568 573413012404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012405 ATP binding site [chemical binding]; other site 573413012406 Mg2+ binding site [ion binding]; other site 573413012407 G-X-G motif; other site 573413012408 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413012409 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413012410 active site 573413012411 catalytic tetrad [active] 573413012412 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 573413012413 active site 573413012414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413012415 Histidine kinase; Region: HisKA_2; pfam07568 573413012416 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 573413012417 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 573413012418 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 573413012419 amino acid transporter; Region: 2A0306; TIGR00909 573413012420 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 573413012421 active site 573413012422 phosphorylation site [posttranslational modification] 573413012423 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 573413012424 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573413012425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413012426 xylose isomerase; Provisional; Region: PRK05474 573413012427 xylose isomerase; Region: xylose_isom_A; TIGR02630 573413012428 cyclase homology domain; Region: CHD; cd07302 573413012429 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413012430 nucleotidyl binding site; other site 573413012431 metal binding site [ion binding]; metal-binding site 573413012432 dimer interface [polypeptide binding]; other site 573413012433 cyclase homology domain; Region: CHD; cd07302 573413012434 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413012435 nucleotidyl binding site; other site 573413012436 metal binding site [ion binding]; metal-binding site 573413012437 dimer interface [polypeptide binding]; other site 573413012438 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 573413012439 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 573413012440 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 573413012441 FecR protein; Region: FecR; pfam04773 573413012442 CHASE2 domain; Region: CHASE2; cl01732 573413012443 CHASE2 domain; Region: CHASE2; cl01732 573413012444 CHASE2 domain; Region: CHASE2; cl01732 573413012445 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 573413012446 cyclase homology domain; Region: CHD; cd07302 573413012447 nucleotidyl binding site; other site 573413012448 metal binding site [ion binding]; metal-binding site 573413012449 dimer interface [polypeptide binding]; other site 573413012450 SMUG: single-strand-selective monofunctional uracil-DNA glycosylase; Region: UDG_F3_SMUG; cd10029 573413012451 active site 573413012452 substrate specificity residue; other site 573413012453 DNA binding site [nucleotide binding] 573413012454 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 573413012455 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573413012456 ATP binding site [chemical binding]; other site 573413012457 Mg++ binding site [ion binding]; other site 573413012458 motif III; other site 573413012459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573413012460 nucleotide binding region [chemical binding]; other site 573413012461 ATP-binding site [chemical binding]; other site 573413012462 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 573413012463 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573413012464 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573413012465 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573413012466 putative acyl-acceptor binding pocket; other site 573413012467 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 573413012468 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573413012469 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 573413012470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413012471 nucleotide binding site [chemical binding]; other site 573413012472 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573413012473 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573413012474 putative acyl-acceptor binding pocket; other site 573413012475 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 573413012476 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 573413012477 active site 573413012478 nucleophile elbow; other site 573413012479 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 573413012480 dimerization interface [polypeptide binding]; other site 573413012481 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413012482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413012483 dimer interface [polypeptide binding]; other site 573413012484 phosphorylation site [posttranslational modification] 573413012485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012486 ATP binding site [chemical binding]; other site 573413012487 Mg2+ binding site [ion binding]; other site 573413012488 G-X-G motif; other site 573413012489 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413012490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012491 active site 573413012492 phosphorylation site [posttranslational modification] 573413012493 intermolecular recognition site; other site 573413012494 dimerization interface [polypeptide binding]; other site 573413012495 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413012496 DNA binding site [nucleotide binding] 573413012497 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 573413012498 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 573413012499 HlyD family secretion protein; Region: HlyD_3; pfam13437 573413012500 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 573413012501 Protein export membrane protein; Region: SecD_SecF; cl14618 573413012502 Outer membrane efflux protein; Region: OEP; pfam02321 573413012503 Outer membrane efflux protein; Region: OEP; pfam02321 573413012504 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573413012505 active site residue [active] 573413012506 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 573413012507 active site residue [active] 573413012508 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 573413012509 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 573413012510 active site residue [active] 573413012511 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 573413012512 active site residue [active] 573413012513 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573413012514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413012515 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413012516 Walker A/P-loop; other site 573413012517 ATP binding site [chemical binding]; other site 573413012518 Q-loop/lid; other site 573413012519 ABC transporter signature motif; other site 573413012520 Walker B; other site 573413012521 D-loop; other site 573413012522 H-loop/switch region; other site 573413012523 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573413012524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012525 dimer interface [polypeptide binding]; other site 573413012526 conserved gate region; other site 573413012527 putative PBP binding loops; other site 573413012528 ABC-ATPase subunit interface; other site 573413012529 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573413012530 NMT1-like family; Region: NMT1_2; pfam13379 573413012531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413012532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413012533 active site 573413012534 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 573413012535 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 573413012536 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573413012537 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573413012538 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573413012539 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 573413012540 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 573413012541 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573413012542 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573413012543 catalytic residue [active] 573413012544 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573413012545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413012546 TPR motif; other site 573413012547 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413012548 binding surface 573413012549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413012550 binding surface 573413012551 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413012552 TPR motif; other site 573413012553 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413012554 Restriction endonuclease; Region: Mrr_cat; pfam04471 573413012555 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 573413012556 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 573413012557 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 573413012558 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 573413012559 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 573413012560 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 573413012561 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 573413012562 trmE is a tRNA modification GTPase; Region: trmE; cd04164 573413012563 G1 box; other site 573413012564 GTP/Mg2+ binding site [chemical binding]; other site 573413012565 Switch I region; other site 573413012566 G2 box; other site 573413012567 Switch II region; other site 573413012568 G3 box; other site 573413012569 G4 box; other site 573413012570 G5 box; other site 573413012571 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 573413012572 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 573413012573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413012574 S-adenosylmethionine binding site [chemical binding]; other site 573413012575 Uncharacterized conserved protein [Function unknown]; Region: COG2014 573413012576 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 573413012577 Domain of unknown function (DUF364); Region: DUF364; pfam04016 573413012578 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 573413012579 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 573413012580 putative ligand binding residues [chemical binding]; other site 573413012581 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413012582 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413012583 ABC-ATPase subunit interface; other site 573413012584 dimer interface [polypeptide binding]; other site 573413012585 putative PBP binding regions; other site 573413012586 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413012587 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 573413012588 Walker A/P-loop; other site 573413012589 ATP binding site [chemical binding]; other site 573413012590 Q-loop/lid; other site 573413012591 ABC transporter signature motif; other site 573413012592 Walker B; other site 573413012593 D-loop; other site 573413012594 H-loop/switch region; other site 573413012595 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 573413012596 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 573413012597 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 573413012598 putative NAD(P) binding site [chemical binding]; other site 573413012599 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 573413012600 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 573413012601 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 573413012602 Ligand Binding Site [chemical binding]; other site 573413012603 Protein of unknown function DUF111; Region: DUF111; pfam01969 573413012604 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 573413012605 Protein of unknown function, DUF399; Region: DUF399; cl01139 573413012606 AIR carboxylase; Region: AIRC; smart01001 573413012607 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 573413012608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413012609 S-adenosylmethionine binding site [chemical binding]; other site 573413012610 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 573413012611 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 573413012612 putative metal binding site [ion binding]; other site 573413012613 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 573413012614 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573413012615 ABC-ATPase subunit interface; other site 573413012616 dimer interface [polypeptide binding]; other site 573413012617 putative PBP binding regions; other site 573413012618 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 573413012619 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573413012620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413012621 dimer interface [polypeptide binding]; other site 573413012622 phosphorylation site [posttranslational modification] 573413012623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012624 ATP binding site [chemical binding]; other site 573413012625 Mg2+ binding site [ion binding]; other site 573413012626 G-X-G motif; other site 573413012627 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413012628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012629 active site 573413012630 phosphorylation site [posttranslational modification] 573413012631 intermolecular recognition site; other site 573413012632 dimerization interface [polypeptide binding]; other site 573413012633 Response regulator receiver domain; Region: Response_reg; pfam00072 573413012634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012635 active site 573413012636 phosphorylation site [posttranslational modification] 573413012637 intermolecular recognition site; other site 573413012638 dimerization interface [polypeptide binding]; other site 573413012639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413012640 Histidine kinase; Region: HisKA_2; pfam07568 573413012641 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 573413012642 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413012643 active site 573413012644 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 573413012645 classical (c) SDRs; Region: SDR_c; cd05233 573413012646 NAD(P) binding site [chemical binding]; other site 573413012647 active site 573413012648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413012649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012650 dimer interface [polypeptide binding]; other site 573413012651 conserved gate region; other site 573413012652 putative PBP binding loops; other site 573413012653 ABC-ATPase subunit interface; other site 573413012654 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 573413012655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573413012656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012657 ABC-ATPase subunit interface; other site 573413012658 putative PBP binding loops; other site 573413012659 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413012660 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413012661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413012662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012663 active site 573413012664 phosphorylation site [posttranslational modification] 573413012665 intermolecular recognition site; other site 573413012666 dimerization interface [polypeptide binding]; other site 573413012667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413012668 dimerization interface [polypeptide binding]; other site 573413012669 DNA binding residues [nucleotide binding] 573413012670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413012671 Histidine kinase; Region: HisKA_3; pfam07730 573413012672 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573413012673 ATP binding site [chemical binding]; other site 573413012674 Mg2+ binding site [ion binding]; other site 573413012675 G-X-G motif; other site 573413012676 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 573413012677 active site 573413012678 dimer interfaces [polypeptide binding]; other site 573413012679 catalytic residues [active] 573413012680 putative transposase OrfB; Reviewed; Region: PHA02517 573413012681 HTH-like domain; Region: HTH_21; pfam13276 573413012682 Integrase core domain; Region: rve; pfam00665 573413012683 Integrase core domain; Region: rve_3; cl15866 573413012684 VanW like protein; Region: VanW; pfam04294 573413012685 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 573413012686 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 573413012687 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573413012688 Walker A/P-loop; other site 573413012689 ATP binding site [chemical binding]; other site 573413012690 Q-loop/lid; other site 573413012691 ABC transporter signature motif; other site 573413012692 Walker B; other site 573413012693 D-loop; other site 573413012694 H-loop/switch region; other site 573413012695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413012696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012697 dimer interface [polypeptide binding]; other site 573413012698 conserved gate region; other site 573413012699 putative PBP binding loops; other site 573413012700 ABC-ATPase subunit interface; other site 573413012701 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 573413012702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012703 dimer interface [polypeptide binding]; other site 573413012704 conserved gate region; other site 573413012705 putative PBP binding loops; other site 573413012706 ABC-ATPase subunit interface; other site 573413012707 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 573413012708 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413012709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413012710 DNA binding site [nucleotide binding] 573413012711 domain linker motif; other site 573413012712 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413012713 ligand binding site [chemical binding]; other site 573413012714 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573413012715 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573413012716 active site 573413012717 catalytic site [active] 573413012718 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413012719 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573413012720 substrate binding site [chemical binding]; other site 573413012721 ATP binding site [chemical binding]; other site 573413012722 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573413012723 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 573413012724 active site 573413012725 metal binding site [ion binding]; metal-binding site 573413012726 catalytic site [active] 573413012727 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413012728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012729 dimer interface [polypeptide binding]; other site 573413012730 conserved gate region; other site 573413012731 putative PBP binding loops; other site 573413012732 ABC-ATPase subunit interface; other site 573413012733 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413012734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012735 putative PBP binding loops; other site 573413012736 dimer interface [polypeptide binding]; other site 573413012737 ABC-ATPase subunit interface; other site 573413012738 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413012739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413012740 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413012741 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573413012742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413012743 Coenzyme A binding pocket [chemical binding]; other site 573413012744 Uncharacterized conserved protein [Function unknown]; Region: COG1633 573413012745 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 573413012746 dinuclear metal binding motif [ion binding]; other site 573413012747 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 573413012748 Predicted transcriptional regulators [Transcription]; Region: COG1733 573413012749 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573413012750 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 573413012751 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 573413012752 NADP binding site [chemical binding]; other site 573413012753 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 573413012754 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 573413012755 putative active site [active] 573413012756 metal binding site [ion binding]; metal-binding site 573413012757 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 573413012758 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 573413012759 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 573413012760 putative active site [active] 573413012761 QueT transporter; Region: QueT; cl01932 573413012762 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413012763 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573413012764 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413012765 Walker A/P-loop; other site 573413012766 ATP binding site [chemical binding]; other site 573413012767 Q-loop/lid; other site 573413012768 ABC transporter signature motif; other site 573413012769 Walker B; other site 573413012770 D-loop; other site 573413012771 H-loop/switch region; other site 573413012772 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413012773 Walker A/P-loop; other site 573413012774 ATP binding site [chemical binding]; other site 573413012775 Q-loop/lid; other site 573413012776 ABC transporter signature motif; other site 573413012777 Walker B; other site 573413012778 D-loop; other site 573413012779 H-loop/switch region; other site 573413012780 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 573413012781 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 573413012782 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573413012783 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413012784 FtsX-like permease family; Region: FtsX; pfam02687 573413012785 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573413012786 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573413012787 FtsX-like permease family; Region: FtsX; pfam02687 573413012788 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573413012789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573413012790 Walker A/P-loop; other site 573413012791 ATP binding site [chemical binding]; other site 573413012792 Q-loop/lid; other site 573413012793 ABC transporter signature motif; other site 573413012794 Walker B; other site 573413012795 D-loop; other site 573413012796 H-loop/switch region; other site 573413012797 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 573413012798 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573413012799 Predicted transcriptional regulators [Transcription]; Region: COG1725 573413012800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413012801 DNA-binding site [nucleotide binding]; DNA binding site 573413012802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413012803 Histidine kinase; Region: HisKA_2; pfam07568 573413012804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012805 ATP binding site [chemical binding]; other site 573413012806 Mg2+ binding site [ion binding]; other site 573413012807 G-X-G motif; other site 573413012808 Response regulator receiver domain; Region: Response_reg; pfam00072 573413012809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012810 active site 573413012811 phosphorylation site [posttranslational modification] 573413012812 intermolecular recognition site; other site 573413012813 dimerization interface [polypeptide binding]; other site 573413012814 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 573413012815 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 573413012816 Peptidase family M48; Region: Peptidase_M48; cl12018 573413012817 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573413012818 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573413012819 G1 box; other site 573413012820 putative GEF interaction site [polypeptide binding]; other site 573413012821 GTP/Mg2+ binding site [chemical binding]; other site 573413012822 Switch I region; other site 573413012823 G2 box; other site 573413012824 G3 box; other site 573413012825 Switch II region; other site 573413012826 G4 box; other site 573413012827 G5 box; other site 573413012828 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573413012829 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573413012830 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573413012831 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573413012832 active site 573413012833 catalytic site [active] 573413012834 FecR protein; Region: FecR; pfam04773 573413012835 peptidase T; Region: peptidase-T; TIGR01882 573413012836 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 573413012837 metal binding site [ion binding]; metal-binding site 573413012838 dimer interface [polypeptide binding]; other site 573413012839 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 573413012840 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 573413012841 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 573413012842 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573413012843 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 573413012844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413012845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413012846 homodimer interface [polypeptide binding]; other site 573413012847 catalytic residue [active] 573413012848 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 573413012849 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 573413012850 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413012851 active site 573413012852 phosphorylation site [posttranslational modification] 573413012853 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573413012854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012855 ATP binding site [chemical binding]; other site 573413012856 Mg2+ binding site [ion binding]; other site 573413012857 G-X-G motif; other site 573413012858 Protein of unknown function (DUF819); Region: DUF819; cl02317 573413012859 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 573413012860 active site 573413012861 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 573413012862 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413012863 active site 573413012864 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 573413012865 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573413012866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413012867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413012868 putative substrate translocation pore; other site 573413012869 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413012870 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413012871 Walker A/P-loop; other site 573413012872 ATP binding site [chemical binding]; other site 573413012873 Q-loop/lid; other site 573413012874 ABC transporter signature motif; other site 573413012875 Walker B; other site 573413012876 D-loop; other site 573413012877 H-loop/switch region; other site 573413012878 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573413012879 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573413012880 Walker A/P-loop; other site 573413012881 ATP binding site [chemical binding]; other site 573413012882 Q-loop/lid; other site 573413012883 ABC transporter signature motif; other site 573413012884 Walker B; other site 573413012885 D-loop; other site 573413012886 H-loop/switch region; other site 573413012887 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573413012888 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 573413012889 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 573413012890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413012891 DNA-binding site [nucleotide binding]; DNA binding site 573413012892 UTRA domain; Region: UTRA; cl17743 573413012893 Protein of unknown function (DUF523); Region: DUF523; pfam04463 573413012894 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 573413012895 Mrr N-terminal domain; Region: Mrr_N; pfam14338 573413012896 Restriction endonuclease; Region: Mrr_cat; pfam04471 573413012897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573413012898 S-adenosylmethionine binding site [chemical binding]; other site 573413012899 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573413012900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413012901 Coenzyme A binding pocket [chemical binding]; other site 573413012902 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413012903 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413012904 active site 573413012905 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 573413012906 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 573413012907 active site 573413012908 short chain dehydrogenase; Provisional; Region: PRK06924 573413012909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413012910 NAD(P) binding site [chemical binding]; other site 573413012911 active site 573413012912 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 573413012913 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573413012914 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573413012915 hinge; other site 573413012916 active site 573413012917 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 573413012918 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 573413012919 tetramer interface [polypeptide binding]; other site 573413012920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413012921 catalytic residue [active] 573413012922 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 573413012923 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413012924 substrate binding site [chemical binding]; other site 573413012925 ATP binding site [chemical binding]; other site 573413012926 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 573413012927 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 573413012928 Part of AAA domain; Region: AAA_19; pfam13245 573413012929 Family description; Region: UvrD_C_2; pfam13538 573413012930 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573413012931 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573413012932 Flavin Reductases; Region: FlaRed; cl00801 573413012933 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 573413012934 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 573413012935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413012936 dimerization interface [polypeptide binding]; other site 573413012937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413012938 dimer interface [polypeptide binding]; other site 573413012939 putative CheW interface [polypeptide binding]; other site 573413012940 short chain dehydrogenase; Provisional; Region: PRK08339 573413012941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413012942 NAD(P) binding site [chemical binding]; other site 573413012943 active site 573413012944 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 573413012945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 573413012946 Transposase; Region: HTH_Tnp_1; cl17663 573413012947 putative transposase OrfB; Reviewed; Region: PHA02517 573413012948 HTH-like domain; Region: HTH_21; pfam13276 573413012949 Integrase core domain; Region: rve; pfam00665 573413012950 Integrase core domain; Region: rve_3; cl15866 573413012951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573413012952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413012953 dimer interface [polypeptide binding]; other site 573413012954 phosphorylation site [posttranslational modification] 573413012955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413012956 ATP binding site [chemical binding]; other site 573413012957 Mg2+ binding site [ion binding]; other site 573413012958 G-X-G motif; other site 573413012959 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573413012960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413012961 active site 573413012962 phosphorylation site [posttranslational modification] 573413012963 intermolecular recognition site; other site 573413012964 dimerization interface [polypeptide binding]; other site 573413012965 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573413012966 DNA binding site [nucleotide binding] 573413012967 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573413012968 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 573413012969 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 573413012970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012971 dimer interface [polypeptide binding]; other site 573413012972 conserved gate region; other site 573413012973 putative PBP binding loops; other site 573413012974 ABC-ATPase subunit interface; other site 573413012975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413012976 dimer interface [polypeptide binding]; other site 573413012977 conserved gate region; other site 573413012978 putative PBP binding loops; other site 573413012979 ABC-ATPase subunit interface; other site 573413012980 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 573413012981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413012982 Walker A/P-loop; other site 573413012983 ATP binding site [chemical binding]; other site 573413012984 Q-loop/lid; other site 573413012985 ABC transporter signature motif; other site 573413012986 Walker B; other site 573413012987 D-loop; other site 573413012988 H-loop/switch region; other site 573413012989 TOBE domain; Region: TOBE_2; pfam08402 573413012990 DHH family; Region: DHH; pfam01368 573413012991 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 573413012992 FOG: CBS domain [General function prediction only]; Region: COG0517 573413012993 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 573413012994 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413012995 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413012996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413012997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413012998 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573413012999 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 573413013000 oligomer interface [polypeptide binding]; other site 573413013001 metal binding site [ion binding]; metal-binding site 573413013002 metal binding site [ion binding]; metal-binding site 573413013003 Cl binding site [ion binding]; other site 573413013004 aspartate ring; other site 573413013005 basic sphincter; other site 573413013006 putative hydrophobic gate; other site 573413013007 periplasmic entrance; other site 573413013008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 573413013009 active site 573413013010 phosphorylation site [posttranslational modification] 573413013011 intermolecular recognition site; other site 573413013012 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573413013013 non-specific DNA binding site [nucleotide binding]; other site 573413013014 salt bridge; other site 573413013015 sequence-specific DNA binding site [nucleotide binding]; other site 573413013016 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 573413013017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413013018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413013019 metal binding site [ion binding]; metal-binding site 573413013020 active site 573413013021 I-site; other site 573413013022 Chorismate mutase type II; Region: CM_2; cl00693 573413013023 Cupin domain; Region: Cupin_2; pfam07883 573413013024 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 573413013025 Cache domain; Region: Cache_1; pfam02743 573413013026 PAS fold; Region: PAS; pfam00989 573413013027 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 573413013028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413013029 Histidine kinase; Region: HisKA_2; pfam07568 573413013030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013031 ATP binding site [chemical binding]; other site 573413013032 Mg2+ binding site [ion binding]; other site 573413013033 G-X-G motif; other site 573413013034 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413013035 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413013036 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 573413013037 ornithine carbamoyltransferase; Validated; Region: PRK02102 573413013038 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573413013039 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573413013040 Amidinotransferase; Region: Amidinotransf; cl12043 573413013041 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 573413013042 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 573413013043 putative catalytic cysteine [active] 573413013044 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 573413013045 putative active site [active] 573413013046 metal binding site [ion binding]; metal-binding site 573413013047 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 573413013048 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 573413013049 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 573413013050 active site 573413013051 dimer interface [polypeptide binding]; other site 573413013052 effector binding site; other site 573413013053 TSCPD domain; Region: TSCPD; pfam12637 573413013054 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573413013055 TrkA-N domain; Region: TrkA_N; pfam02254 573413013056 TrkA-C domain; Region: TrkA_C; pfam02080 573413013057 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573413013058 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 573413013059 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 573413013060 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 573413013061 active site 573413013062 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 573413013063 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 573413013064 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 573413013065 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 573413013066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573413013067 FeS/SAM binding site; other site 573413013068 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 573413013069 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 573413013070 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 573413013071 Potassium binding sites [ion binding]; other site 573413013072 Cesium cation binding sites [ion binding]; other site 573413013073 Hexokinase [Carbohydrate transport and metabolism]; Region: COG5026 573413013074 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573413013075 nucleotide binding site [chemical binding]; other site 573413013076 Hexokinase; Region: Hexokinase_2; pfam03727 573413013077 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 573413013078 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 573413013079 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 573413013080 active site 573413013081 phosphorylation site [posttranslational modification] 573413013082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013083 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013084 active site 573413013085 phosphorylation site [posttranslational modification] 573413013086 intermolecular recognition site; other site 573413013087 dimerization interface [polypeptide binding]; other site 573413013088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013089 phosphorylation site [posttranslational modification] 573413013090 dimer interface [polypeptide binding]; other site 573413013091 PAS domain; Region: PAS; smart00091 573413013092 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 573413013093 putative active site [active] 573413013094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013095 dimer interface [polypeptide binding]; other site 573413013096 phosphorylation site [posttranslational modification] 573413013097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013098 ATP binding site [chemical binding]; other site 573413013099 Mg2+ binding site [ion binding]; other site 573413013100 G-X-G motif; other site 573413013101 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573413013102 AAA domain; Region: AAA_26; pfam13500 573413013103 DRTGG domain; Region: DRTGG; pfam07085 573413013104 threonine synthase; Validated; Region: PRK06381 573413013105 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 573413013106 glutamate dehydrogenase; Provisional; Region: PRK14030 573413013107 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573413013108 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 573413013109 NAD(P) binding site [chemical binding]; other site 573413013110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013111 active site 573413013112 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013113 phosphorylation site [posttranslational modification] 573413013114 intermolecular recognition site; other site 573413013115 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 573413013116 aspartate aminotransferase; Provisional; Region: PRK07568 573413013117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573413013118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413013119 homodimer interface [polypeptide binding]; other site 573413013120 catalytic residue [active] 573413013121 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013123 active site 573413013124 phosphorylation site [posttranslational modification] 573413013125 intermolecular recognition site; other site 573413013126 dimerization interface [polypeptide binding]; other site 573413013127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413013128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013129 dimer interface [polypeptide binding]; other site 573413013130 phosphorylation site [posttranslational modification] 573413013131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013132 ATP binding site [chemical binding]; other site 573413013133 Mg2+ binding site [ion binding]; other site 573413013134 G-X-G motif; other site 573413013135 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 573413013136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013137 active site 573413013138 phosphorylation site [posttranslational modification] 573413013139 intermolecular recognition site; other site 573413013140 dimerization interface [polypeptide binding]; other site 573413013141 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 573413013142 putative binding surface; other site 573413013143 active site 573413013144 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013146 active site 573413013147 phosphorylation site [posttranslational modification] 573413013148 intermolecular recognition site; other site 573413013149 dimerization interface [polypeptide binding]; other site 573413013150 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573413013151 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573413013152 active site 573413013153 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 573413013154 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 573413013155 CAP-like domain; other site 573413013156 active site 573413013157 primary dimer interface [polypeptide binding]; other site 573413013158 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 573413013159 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573413013160 ATP binding site [chemical binding]; other site 573413013161 Mg2+ binding site [ion binding]; other site 573413013162 G-X-G motif; other site 573413013163 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573413013164 anchoring element; other site 573413013165 dimer interface [polypeptide binding]; other site 573413013166 ATP binding site [chemical binding]; other site 573413013167 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 573413013168 active site 573413013169 putative metal-binding site [ion binding]; other site 573413013170 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573413013171 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 573413013172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 573413013173 putative active site [active] 573413013174 heme pocket [chemical binding]; other site 573413013175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013176 dimer interface [polypeptide binding]; other site 573413013177 phosphorylation site [posttranslational modification] 573413013178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013179 ATP binding site [chemical binding]; other site 573413013180 Mg2+ binding site [ion binding]; other site 573413013181 G-X-G motif; other site 573413013182 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013184 active site 573413013185 phosphorylation site [posttranslational modification] 573413013186 intermolecular recognition site; other site 573413013187 dimerization interface [polypeptide binding]; other site 573413013188 Repair protein; Region: Repair_PSII; pfam04536 573413013189 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 573413013190 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573413013191 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 573413013192 oligomer interface [polypeptide binding]; other site 573413013193 tandem repeat interface [polypeptide binding]; other site 573413013194 active site residues [active] 573413013195 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 573413013196 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 573413013197 tandem repeat interface [polypeptide binding]; other site 573413013198 oligomer interface [polypeptide binding]; other site 573413013199 active site residues [active] 573413013200 Cache domain; Region: Cache_1; pfam02743 573413013201 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413013202 dimerization interface [polypeptide binding]; other site 573413013203 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413013204 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413013205 dimer interface [polypeptide binding]; other site 573413013206 putative CheW interface [polypeptide binding]; other site 573413013207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 573413013208 hydroxyglutarate oxidase; Provisional; Region: PRK11728 573413013209 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 573413013210 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 573413013211 catalytic loop [active] 573413013212 iron binding site [ion binding]; other site 573413013213 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 573413013214 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 573413013215 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 573413013216 active site 573413013217 catalytic residues [active] 573413013218 metal binding site [ion binding]; metal-binding site 573413013219 homodimer binding site [polypeptide binding]; other site 573413013220 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 573413013221 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573413013222 carboxyltransferase (CT) interaction site; other site 573413013223 biotinylation site [posttranslational modification]; other site 573413013224 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883 573413013225 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 573413013226 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 573413013227 active site 573413013228 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573413013229 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 573413013230 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 573413013231 putative ligand binding site [chemical binding]; other site 573413013232 putative NAD binding site [chemical binding]; other site 573413013233 catalytic site [active] 573413013234 phosphoenolpyruvate carboxykinase; Provisional; Region: PRK04210 573413013235 active site 573413013236 metal-binding site [ion binding] 573413013237 nucleotide-binding site [chemical binding]; other site 573413013238 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 573413013239 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573413013240 NAD binding site [chemical binding]; other site 573413013241 ligand binding site [chemical binding]; other site 573413013242 catalytic site [active] 573413013243 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 573413013244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 573413013245 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413013246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573413013247 ligand binding site [chemical binding]; other site 573413013248 flexible hinge region; other site 573413013249 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 573413013250 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573413013251 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 573413013252 mce related protein; Region: MCE; pfam02470 573413013253 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 573413013254 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 573413013255 Walker A/P-loop; other site 573413013256 ATP binding site [chemical binding]; other site 573413013257 Q-loop/lid; other site 573413013258 ABC transporter signature motif; other site 573413013259 Walker B; other site 573413013260 D-loop; other site 573413013261 H-loop/switch region; other site 573413013262 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 573413013263 Permease; Region: Permease; pfam02405 573413013264 Cache domain; Region: Cache_1; pfam02743 573413013265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413013266 dimerization interface [polypeptide binding]; other site 573413013267 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 573413013268 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 573413013269 dimer interface [polypeptide binding]; other site 573413013270 putative CheW interface [polypeptide binding]; other site 573413013271 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 573413013272 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 573413013273 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 573413013274 putative dimer interface [polypeptide binding]; other site 573413013275 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573413013276 active site 573413013277 metal binding site [ion binding]; metal-binding site 573413013278 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 573413013279 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 573413013280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013281 active site 573413013282 phosphorylation site [posttranslational modification] 573413013283 intermolecular recognition site; other site 573413013284 dimerization interface [polypeptide binding]; other site 573413013285 CheB methylesterase; Region: CheB_methylest; pfam01339 573413013286 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 573413013287 Homeodomain-like domain; Region: HTH_32; pfam13565 573413013288 Integrase core domain; Region: rve; pfam00665 573413013289 Integrase core domain; Region: rve_3; pfam13683 573413013290 Transposase; Region: HTH_Tnp_1; pfam01527 573413013291 Bifunctional nuclease; Region: DNase-RNase; cl00553 573413013292 CTP synthetase; Validated; Region: pyrG; PRK05380 573413013293 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573413013294 Catalytic site [active] 573413013295 active site 573413013296 UTP binding site [chemical binding]; other site 573413013297 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573413013298 active site 573413013299 putative oxyanion hole; other site 573413013300 catalytic triad [active] 573413013301 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 573413013302 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 573413013303 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 573413013304 Walker A/P-loop; other site 573413013305 ATP binding site [chemical binding]; other site 573413013306 Q-loop/lid; other site 573413013307 ABC transporter signature motif; other site 573413013308 Walker B; other site 573413013309 D-loop; other site 573413013310 H-loop/switch region; other site 573413013311 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 573413013312 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 573413013313 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 573413013314 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 573413013315 Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482 573413013316 30S subunit binding site; other site 573413013317 HPr kinase/phosphorylase; Provisional; Region: PRK05428 573413013318 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 573413013319 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 573413013320 Hpr binding site; other site 573413013321 active site 573413013322 homohexamer subunit interaction site [polypeptide binding]; other site 573413013323 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 573413013324 dimerization domain swap beta strand [polypeptide binding]; other site 573413013325 regulatory protein interface [polypeptide binding]; other site 573413013326 active site 573413013327 regulatory phosphorylation site [posttranslational modification]; other site 573413013328 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 573413013329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573413013330 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573413013331 dimerization interface [polypeptide binding]; other site 573413013332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013333 dimer interface [polypeptide binding]; other site 573413013334 phosphorylation site [posttranslational modification] 573413013335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013336 ATP binding site [chemical binding]; other site 573413013337 Mg2+ binding site [ion binding]; other site 573413013338 G-X-G motif; other site 573413013339 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 573413013340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013341 active site 573413013342 phosphorylation site [posttranslational modification] 573413013343 intermolecular recognition site; other site 573413013344 dimerization interface [polypeptide binding]; other site 573413013345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573413013346 Walker A motif; other site 573413013347 ATP binding site [chemical binding]; other site 573413013348 Walker B motif; other site 573413013349 arginine finger; other site 573413013350 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 573413013351 LexA repressor; Validated; Region: PRK00215 573413013352 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573413013353 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573413013354 Catalytic site [active] 573413013355 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 573413013356 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573413013357 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573413013358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 573413013359 aromatic acid decarboxylase; Validated; Region: PRK05920 573413013360 Flavoprotein; Region: Flavoprotein; pfam02441 573413013361 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 573413013362 UbiA prenyltransferase family; Region: UbiA; pfam01040 573413013363 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 573413013364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573413013365 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 573413013366 ligand binding site [chemical binding]; other site 573413013367 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 573413013368 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 573413013369 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573413013370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 573413013371 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573413013372 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573413013373 Walker A/P-loop; other site 573413013374 ATP binding site [chemical binding]; other site 573413013375 Q-loop/lid; other site 573413013376 ABC transporter signature motif; other site 573413013377 Walker B; other site 573413013378 D-loop; other site 573413013379 H-loop/switch region; other site 573413013380 Cupin domain; Region: Cupin_2; cl17218 573413013381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573413013382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573413013383 Walker A/P-loop; other site 573413013384 ATP binding site [chemical binding]; other site 573413013385 Q-loop/lid; other site 573413013386 ABC transporter signature motif; other site 573413013387 Walker B; other site 573413013388 D-loop; other site 573413013389 H-loop/switch region; other site 573413013390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573413013391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413013392 dimer interface [polypeptide binding]; other site 573413013393 conserved gate region; other site 573413013394 putative PBP binding loops; other site 573413013395 ABC-ATPase subunit interface; other site 573413013396 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 573413013397 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573413013398 GIY-YIG motif/motif A; other site 573413013399 active site 573413013400 catalytic site [active] 573413013401 putative DNA binding site [nucleotide binding]; other site 573413013402 metal binding site [ion binding]; metal-binding site 573413013403 UvrB/uvrC motif; Region: UVR; pfam02151 573413013404 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573413013405 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 573413013406 DNA binding site [nucleotide binding] 573413013407 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013408 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413013409 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013410 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413013411 TM-ABC transporter signature motif; other site 573413013412 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 573413013413 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413013414 Walker A/P-loop; other site 573413013415 ATP binding site [chemical binding]; other site 573413013416 Q-loop/lid; other site 573413013417 ABC transporter signature motif; other site 573413013418 Walker B; other site 573413013419 D-loop; other site 573413013420 H-loop/switch region; other site 573413013421 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413013422 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 573413013423 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413013424 putative ligand binding site [chemical binding]; other site 573413013425 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 573413013426 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 573413013427 putative ligand binding site [chemical binding]; other site 573413013428 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013430 active site 573413013431 phosphorylation site [posttranslational modification] 573413013432 intermolecular recognition site; other site 573413013433 dimerization interface [polypeptide binding]; other site 573413013434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573413013435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013437 Histidine kinase; Region: His_kinase; pfam06580 573413013438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013439 ATP binding site [chemical binding]; other site 573413013440 Mg2+ binding site [ion binding]; other site 573413013441 G-X-G motif; other site 573413013442 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 573413013443 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413013444 ligand binding site [chemical binding]; other site 573413013445 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 573413013446 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573413013447 Interdomain contacts; other site 573413013448 Cytokine receptor motif; other site 573413013449 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573413013450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413013451 TPR motif; other site 573413013452 binding surface 573413013453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413013454 binding surface 573413013455 TPR motif; other site 573413013456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413013457 binding surface 573413013458 TPR motif; other site 573413013459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413013460 binding surface 573413013461 TPR motif; other site 573413013462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413013463 binding surface 573413013464 TPR motif; other site 573413013465 HDOD domain; Region: HDOD; pfam08668 573413013466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573413013467 Zn2+ binding site [ion binding]; other site 573413013468 Mg2+ binding site [ion binding]; other site 573413013469 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 573413013470 Transcriptional regulators [Transcription]; Region: FadR; COG2186 573413013471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573413013472 DNA-binding site [nucleotide binding]; DNA binding site 573413013473 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 573413013474 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 573413013475 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 573413013476 active site 573413013477 NAD binding site [chemical binding]; other site 573413013478 metal binding site [ion binding]; metal-binding site 573413013479 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 573413013480 active site 573413013481 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573413013482 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 573413013483 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 573413013484 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573413013485 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 573413013486 short chain dehydrogenase; Provisional; Region: PRK06180 573413013487 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 573413013488 NADP binding site [chemical binding]; other site 573413013489 active site 573413013490 steroid binding site; other site 573413013491 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 573413013492 hypothetical protein; Provisional; Region: PRK09256 573413013493 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 573413013494 putative ligand binding site [chemical binding]; other site 573413013495 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 573413013496 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 573413013497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413013498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413013499 dimer interface [polypeptide binding]; other site 573413013500 conserved gate region; other site 573413013501 putative PBP binding loops; other site 573413013502 ABC-ATPase subunit interface; other site 573413013503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413013504 dimer interface [polypeptide binding]; other site 573413013505 conserved gate region; other site 573413013506 putative PBP binding loops; other site 573413013507 ABC-ATPase subunit interface; other site 573413013508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573413013509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413013510 Histidine kinase; Region: HisKA_3; pfam07730 573413013511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013512 ATP binding site [chemical binding]; other site 573413013513 Mg2+ binding site [ion binding]; other site 573413013514 G-X-G motif; other site 573413013515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573413013516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013517 active site 573413013518 phosphorylation site [posttranslational modification] 573413013519 intermolecular recognition site; other site 573413013520 dimerization interface [polypeptide binding]; other site 573413013521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573413013522 DNA binding residues [nucleotide binding] 573413013523 dimerization interface [polypeptide binding]; other site 573413013524 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573413013525 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413013526 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 573413013527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573413013528 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 573413013529 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 573413013530 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 573413013531 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573413013532 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573413013533 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 573413013534 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573413013535 NAD(P) binding site [chemical binding]; other site 573413013536 putative active site [active] 573413013537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573413013538 active site 573413013539 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 573413013540 Ligand Binding Site [chemical binding]; other site 573413013541 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 573413013542 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 573413013543 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 573413013544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413013545 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413013546 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413013547 Walker A/P-loop; other site 573413013548 ATP binding site [chemical binding]; other site 573413013549 Q-loop/lid; other site 573413013550 ABC transporter signature motif; other site 573413013551 Walker B; other site 573413013552 D-loop; other site 573413013553 H-loop/switch region; other site 573413013554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413013555 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413013556 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573413013557 Walker A/P-loop; other site 573413013558 ATP binding site [chemical binding]; other site 573413013559 Q-loop/lid; other site 573413013560 ABC transporter signature motif; other site 573413013561 Walker B; other site 573413013562 D-loop; other site 573413013563 H-loop/switch region; other site 573413013564 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 573413013565 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 573413013566 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 573413013567 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 573413013568 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 573413013569 peptide binding site [polypeptide binding]; other site 573413013570 4-alpha-glucanotransferase; Provisional; Region: PRK14508 573413013571 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 573413013572 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573413013573 substrate binding site; other site 573413013574 dimer interface; other site 573413013575 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573413013576 homotrimer interaction site [polypeptide binding]; other site 573413013577 zinc binding site [ion binding]; other site 573413013578 CDP-binding sites; other site 573413013579 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573413013580 endonuclease III; Region: ENDO3c; smart00478 573413013581 minor groove reading motif; other site 573413013582 helix-hairpin-helix signature motif; other site 573413013583 substrate binding pocket [chemical binding]; other site 573413013584 active site 573413013585 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573413013586 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 573413013587 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573413013588 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573413013589 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK14607 573413013590 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573413013591 glutamine binding [chemical binding]; other site 573413013592 catalytic triad [active] 573413013593 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573413013594 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573413013595 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573413013596 active site 573413013597 ribulose/triose binding site [chemical binding]; other site 573413013598 phosphate binding site [ion binding]; other site 573413013599 substrate (anthranilate) binding pocket [chemical binding]; other site 573413013600 product (indole) binding pocket [chemical binding]; other site 573413013601 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 573413013602 active site 573413013603 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 573413013604 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573413013605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573413013606 catalytic residue [active] 573413013607 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573413013608 substrate binding site [chemical binding]; other site 573413013609 active site 573413013610 catalytic residues [active] 573413013611 heterodimer interface [polypeptide binding]; other site 573413013612 41 helicase; Provisional; Region: 41; PHA02542 573413013613 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573413013614 elongation factor G; Reviewed; Region: PRK12740 573413013615 G1 box; other site 573413013616 putative GEF interaction site [polypeptide binding]; other site 573413013617 GTP/Mg2+ binding site [chemical binding]; other site 573413013618 Switch I region; other site 573413013619 G2 box; other site 573413013620 G3 box; other site 573413013621 Switch II region; other site 573413013622 G4 box; other site 573413013623 G5 box; other site 573413013624 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 573413013625 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573413013626 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 573413013627 Protein of unknown function DUF72; Region: DUF72; pfam01904 573413013628 HEAT repeats; Region: HEAT_2; pfam13646 573413013629 HEAT repeats; Region: HEAT_2; pfam13646 573413013630 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 573413013631 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 573413013632 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573413013633 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573413013634 dimer interface [polypeptide binding]; other site 573413013635 phosphorylation site [posttranslational modification] 573413013636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413013637 ATP binding site [chemical binding]; other site 573413013638 Mg2+ binding site [ion binding]; other site 573413013639 G-X-G motif; other site 573413013640 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413013641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013642 active site 573413013643 phosphorylation site [posttranslational modification] 573413013644 intermolecular recognition site; other site 573413013645 dimerization interface [polypeptide binding]; other site 573413013646 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013648 active site 573413013649 phosphorylation site [posttranslational modification] 573413013650 intermolecular recognition site; other site 573413013651 dimerization interface [polypeptide binding]; other site 573413013652 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 573413013653 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 573413013654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013655 active site 573413013656 phosphorylation site [posttranslational modification] 573413013657 intermolecular recognition site; other site 573413013658 dimerization interface [polypeptide binding]; other site 573413013659 Response regulator receiver domain; Region: Response_reg; pfam00072 573413013660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413013661 active site 573413013662 phosphorylation site [posttranslational modification] 573413013663 intermolecular recognition site; other site 573413013664 dimerization interface [polypeptide binding]; other site 573413013665 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 573413013666 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK09616 573413013667 tRNA synthetase B5 domain; Region: B5; pfam03484 573413013668 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573413013669 dimer interface [polypeptide binding]; other site 573413013670 motif 1; other site 573413013671 motif 3; other site 573413013672 motif 2; other site 573413013673 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 573413013674 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573413013675 dimer interface [polypeptide binding]; other site 573413013676 motif 1; other site 573413013677 active site 573413013678 motif 2; other site 573413013679 motif 3; other site 573413013680 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 573413013681 active site 573413013682 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 573413013683 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 573413013684 active site 573413013685 putative substrate binding pocket [chemical binding]; other site 573413013686 purine nucleoside phosphorylase; Provisional; Region: PRK08202 573413013687 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 573413013688 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 573413013689 ligand binding site [chemical binding]; other site 573413013690 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013691 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413013692 TM-ABC transporter signature motif; other site 573413013693 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013694 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 573413013695 TM-ABC transporter signature motif; other site 573413013696 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 573413013697 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413013698 Walker A/P-loop; other site 573413013699 ATP binding site [chemical binding]; other site 573413013700 Q-loop/lid; other site 573413013701 ABC transporter signature motif; other site 573413013702 Walker B; other site 573413013703 D-loop; other site 573413013704 H-loop/switch region; other site 573413013705 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413013706 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 573413013707 dimer interface [polypeptide binding]; other site 573413013708 Alkaline phosphatase homologues; Region: alkPPc; smart00098 573413013709 active site 573413013710 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 573413013711 YibE/F-like protein; Region: YibE_F; pfam07907 573413013712 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 573413013713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 573413013714 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413013715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413013716 metal binding site [ion binding]; metal-binding site 573413013717 active site 573413013718 I-site; other site 573413013719 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413013720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413013721 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573413013722 Walker A/P-loop; other site 573413013723 ATP binding site [chemical binding]; other site 573413013724 Q-loop/lid; other site 573413013725 ABC transporter signature motif; other site 573413013726 Walker B; other site 573413013727 D-loop; other site 573413013728 H-loop/switch region; other site 573413013729 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413013730 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413013731 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413013732 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 573413013733 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 573413013734 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 573413013735 ligand binding site [chemical binding]; other site 573413013736 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 573413013737 intersubunit interface [polypeptide binding]; other site 573413013738 active site 573413013739 catalytic residue [active] 573413013740 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573413013741 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 573413013742 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573413013743 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 573413013744 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573413013745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 573413013746 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 573413013747 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 573413013748 hydrophobic ligand binding site; other site 573413013749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573413013750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413013751 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573413013752 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413013753 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573413013754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573413013755 active site 573413013756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573413013757 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 573413013758 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573413013759 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 573413013760 Protein of unknown function (DUF497); Region: DUF497; pfam04365 573413013761 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 573413013762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573413013763 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 573413013764 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573413013765 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 573413013766 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 573413013767 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 573413013768 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 573413013769 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 573413013770 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 573413013771 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 573413013772 active site 573413013773 catalytic residues [active] 573413013774 metal binding site [ion binding]; metal-binding site 573413013775 DmpG-like communication domain; Region: DmpG_comm; pfam07836 573413013776 acetaldehyde dehydrogenase; Validated; Region: PRK08300 573413013777 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573413013778 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 573413013779 Uncharacterized conserved protein [Function unknown]; Region: COG4925 573413013780 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 573413013781 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573413013782 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573413013783 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573413013784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573413013785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573413013786 active site 573413013787 catalytic tetrad [active] 573413013788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573413013789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413013790 Coenzyme A binding pocket [chemical binding]; other site 573413013791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573413013792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413013793 Coenzyme A binding pocket [chemical binding]; other site 573413013794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413013795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413013796 putative substrate translocation pore; other site 573413013797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573413013798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573413013799 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 573413013800 Acyltransferase family; Region: Acyl_transf_3; pfam01757 573413013801 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573413013802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573413013803 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 573413013804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013806 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 573413013807 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573413013808 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 573413013809 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 573413013810 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573413013811 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573413013812 DNA binding site [nucleotide binding] 573413013813 domain linker motif; other site 573413013814 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573413013815 dimerization interface [polypeptide binding]; other site 573413013816 ligand binding site [chemical binding]; other site 573413013817 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573413013818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573413013819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573413013820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413013821 dimer interface [polypeptide binding]; other site 573413013822 conserved gate region; other site 573413013823 putative PBP binding loops; other site 573413013824 ABC-ATPase subunit interface; other site 573413013825 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573413013826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573413013827 dimer interface [polypeptide binding]; other site 573413013828 ABC-ATPase subunit interface; other site 573413013829 putative PBP binding loops; other site 573413013830 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573413013831 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573413013832 Predicted transcriptional regulators [Transcription]; Region: COG1733 573413013833 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573413013834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573413013835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573413013836 putative substrate translocation pore; other site 573413013837 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 573413013838 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 573413013839 active site 573413013840 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573413013841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573413013842 Coenzyme A binding pocket [chemical binding]; other site 573413013843 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 573413013844 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 573413013845 tetramer interface [polypeptide binding]; other site 573413013846 active site 573413013847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013848 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413013849 TM-ABC transporter signature motif; other site 573413013850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 573413013851 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573413013852 TM-ABC transporter signature motif; other site 573413013853 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 573413013854 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 573413013855 Walker A/P-loop; other site 573413013856 ATP binding site [chemical binding]; other site 573413013857 Q-loop/lid; other site 573413013858 ABC transporter signature motif; other site 573413013859 Walker B; other site 573413013860 D-loop; other site 573413013861 H-loop/switch region; other site 573413013862 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 573413013863 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573413013864 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 573413013865 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573413013866 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 573413013867 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573413013868 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573413013869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573413013870 nucleotide binding site [chemical binding]; other site 573413013871 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573413013872 active site 573413013873 catalytic residues [active] 573413013874 metal binding site [ion binding]; metal-binding site 573413013875 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 573413013876 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 573413013877 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573413013878 active site 573413013879 catalytic residues [active] 573413013880 metal binding site [ion binding]; metal-binding site 573413013881 HD domain; Region: HD_3; pfam13023 573413013882 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 573413013883 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573413013884 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573413013885 active site 573413013886 HIGH motif; other site 573413013887 dimer interface [polypeptide binding]; other site 573413013888 KMSKS motif; other site 573413013889 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573413013890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573413013891 Coenzyme A binding pocket [chemical binding]; other site 573413013892 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 573413013893 homodimer interaction site [polypeptide binding]; other site 573413013894 cofactor binding site; other site 573413013895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013896 Helix-turn-helix domain; Region: HTH_18; pfam12833 573413013897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 573413013898 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 573413013899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 573413013900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 573413013901 metal binding site [ion binding]; metal-binding site 573413013902 active site 573413013903 I-site; other site 573413013904 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 573413013905 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 573413013906 active site 573413013907 metal-binding site 573413013908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573413013909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573413013910 catalytic residue [active] 573413013911 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573413013912 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 573413013913 PYR/PP interface [polypeptide binding]; other site 573413013914 dimer interface [polypeptide binding]; other site 573413013915 TPP binding site [chemical binding]; other site 573413013916 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 573413013917 TPP-binding site; other site 573413013918 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 573413013919 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 573413013920 tetramer interface [polypeptide binding]; other site 573413013921 active site 573413013922 Mg2+/Mn2+ binding site [ion binding]; other site 573413013923 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 573413013924 active site 573413013925 metal-binding site 573413013926 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573413013927 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573413013928 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 573413013929 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573413013930 Ligand binding site; other site 573413013931 Putative Catalytic site; other site 573413013932 DXD motif; other site 573413013933 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 573413013934 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 573413013935 GtrA-like protein; Region: GtrA; pfam04138 573413013936 Predicted membrane protein [Function unknown]; Region: COG2246 573413013937 GtrA-like protein; Region: GtrA; pfam04138 573413013938 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013939 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 573413013940 putative ADP-binding pocket [chemical binding]; other site 573413013941 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 573413013942 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573413013943 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 573413013944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013945 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 573413013946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013947 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 573413013948 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013949 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573413013950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413013951 active site 573413013952 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573413013953 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 573413013954 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 573413013955 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 573413013956 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573413013957 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573413013958 NADP binding site [chemical binding]; other site 573413013959 active site 573413013960 putative substrate binding site [chemical binding]; other site 573413013961 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 573413013962 Protein of unknown function (DUF616); Region: DUF616; pfam04765 573413013963 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573413013964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573413013965 NAD(P) binding site [chemical binding]; other site 573413013966 active site 573413013967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013968 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 573413013969 putative ADP-binding pocket [chemical binding]; other site 573413013970 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u1; cd10925 573413013971 NodB motif; other site 573413013972 putative active site [active] 573413013973 putative catalytic site [active] 573413013974 putative Zn binding site [ion binding]; other site 573413013975 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573413013976 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573413013977 active site 573413013978 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 573413013979 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 573413013980 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573413013981 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573413013982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573413013983 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573413013984 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 573413013985 metal-binding site 573413013986 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 573413013987 trimer interface [polypeptide binding]; other site 573413013988 active site 573413013989 substrate binding site [chemical binding]; other site 573413013990 CoA binding site [chemical binding]; other site 573413013991 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 573413013992 NeuB family; Region: NeuB; pfam03102 573413013993 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 573413013994 ligand binding site; other site 573413013995 tetramer interface; other site 573413013996 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 573413013997 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573413013998 active site 573413013999 motif I; other site 573413014000 motif II; other site 573413014001 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573413014002 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573413014003 Walker A/P-loop; other site 573413014004 ATP binding site [chemical binding]; other site 573413014005 Q-loop/lid; other site 573413014006 ABC transporter signature motif; other site 573413014007 Walker B; other site 573413014008 D-loop; other site 573413014009 H-loop/switch region; other site 573413014010 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 573413014011 putative carbohydrate binding site [chemical binding]; other site 573413014012 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573413014013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573413014014 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573413014015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573413014016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573413014017 Walker A/P-loop; other site 573413014018 ATP binding site [chemical binding]; other site 573413014019 Q-loop/lid; other site 573413014020 ABC transporter signature motif; other site 573413014021 Walker B; other site 573413014022 D-loop; other site 573413014023 H-loop/switch region; other site 573413014024 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 573413014025 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 573413014026 NADP binding site [chemical binding]; other site 573413014027 active site 573413014028 putative substrate binding site [chemical binding]; other site 573413014029 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 573413014030 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 573413014031 NADP-binding site; other site 573413014032 homotetramer interface [polypeptide binding]; other site 573413014033 substrate binding site [chemical binding]; other site 573413014034 homodimer interface [polypeptide binding]; other site 573413014035 active site 573413014036 YcfA-like protein; Region: YcfA; pfam07927 573413014037 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 573413014038 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 573413014039 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573413014040 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573413014041 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 573413014042 Protein of unknown function DUF86; Region: DUF86; pfam01934 573413014043 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 573413014044 active site 573413014045 NTP binding site [chemical binding]; other site 573413014046 metal binding triad [ion binding]; metal-binding site 573413014047 antibiotic binding site [chemical binding]; other site 573413014048 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573413014049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 573413014050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573413014051 active site 573413014052 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573413014053 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 573413014054 substrate binding site [chemical binding]; other site 573413014055 ATP binding site [chemical binding]; other site 573413014056 Response regulator receiver domain; Region: Response_reg; pfam00072 573413014057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573413014058 active site 573413014059 phosphorylation site [posttranslational modification] 573413014060 intermolecular recognition site; other site 573413014061 dimerization interface [polypeptide binding]; other site 573413014062 PAS fold; Region: PAS_4; pfam08448 573413014063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573413014064 Histidine kinase; Region: HisKA_2; pfam07568 573413014065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413014066 ATP binding site [chemical binding]; other site 573413014067 Mg2+ binding site [ion binding]; other site 573413014068 G-X-G motif; other site 573413014069 Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568 573413014070 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 573413014071 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573413014072 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 573413014073 catalytic residues [active] 573413014074 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 573413014075 metal binding site [ion binding]; metal-binding site 573413014076 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 573413014077 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 573413014078 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573413014079 FAD binding site [chemical binding]; other site 573413014080 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573413014081 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573413014082 TPP-binding site [chemical binding]; other site 573413014083 dimer interface [polypeptide binding]; other site 573413014084 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573413014085 PYR/PP interface [polypeptide binding]; other site 573413014086 dimer interface [polypeptide binding]; other site 573413014087 TPP binding site [chemical binding]; other site 573413014088 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573413014089 EamA-like transporter family; Region: EamA; pfam00892 573413014090 EamA-like transporter family; Region: EamA; cl17759 573413014091 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573413014092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573413014093 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 573413014094 dimerization interface [polypeptide binding]; other site 573413014095 substrate binding pocket [chemical binding]; other site 573413014096 FMN-binding domain; Region: FMN_bind; pfam04205 573413014097 FMN-binding domain; Region: FMN_bind; cl01081 573413014098 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 573413014099 L-aspartate oxidase; Provisional; Region: PRK06175 573413014100 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 573413014101 Divergent AAA domain; Region: AAA_4; pfam04326 573413014102 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 573413014103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 573413014104 putative DNA binding site [nucleotide binding]; other site 573413014105 putative Zn2+ binding site [ion binding]; other site 573413014106 putative transposase OrfB; Reviewed; Region: PHA02517 573413014107 HTH-like domain; Region: HTH_21; pfam13276 573413014108 Integrase core domain; Region: rve; pfam00665 573413014109 Integrase core domain; Region: rve_3; pfam13683 573413014110 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573413014111 active site 573413014112 Tetratricopeptide repeat; Region: TPR_16; pfam13432 573413014113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413014114 TPR motif; other site 573413014115 binding surface 573413014116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413014117 TPR motif; other site 573413014118 binding surface 573413014119 TPR repeat; Region: TPR_11; pfam13414 573413014120 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573413014121 binding surface 573413014122 TPR motif; other site 573413014123 TPR repeat; Region: TPR_11; pfam13414 573413014124 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 573413014125 DNA repair protein RadA; Provisional; Region: PRK11823 573413014126 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573413014127 Walker A motif; other site 573413014128 ATP binding site [chemical binding]; other site 573413014129 Walker B motif; other site 573413014130 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573413014131 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 573413014132 putative trimer interface [polypeptide binding]; other site 573413014133 putative CoA binding site [chemical binding]; other site 573413014134 ParB-like nuclease domain; Region: ParB; smart00470 573413014135 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573413014136 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573413014137 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573413014138 P-loop; other site 573413014139 Magnesium ion binding site [ion binding]; other site 573413014140 NifU-like domain; Region: NifU; pfam01106 573413014141 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573413014142 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 573413014143 active site 573413014144 DNA gyrase subunit A; Validated; Region: PRK05560 573413014145 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573413014146 CAP-like domain; other site 573413014147 active site 573413014148 primary dimer interface [polypeptide binding]; other site 573413014149 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014151 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014152 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014153 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014154 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573413014155 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 573413014156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573413014157 Mg2+ binding site [ion binding]; other site 573413014158 G-X-G motif; other site 573413014159 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573413014160 anchoring element; other site 573413014161 dimer interface [polypeptide binding]; other site 573413014162 ATP binding site [chemical binding]; other site 573413014163 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573413014164 active site 573413014165 putative metal-binding site [ion binding]; other site 573413014166 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986